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Ethical Aspects Of Prenatal Genetic Diagnostics, Hille Haker

Theology: Faculty Publications and Other Works

Starting with some basic distinctions, i.e. the distinction between an ethics of human self-fulfilment ,of individual and social values and of virtues on one hand, and an ethics of individual rights, of obligation and of social justice on the other, this paper explores the manifold scenario of the problems of prenatal diagnosis with respect to these different aspects of ethical analysis. This is followed by a normative evaluation of the status of the human embryo, and by an elaboration of different adressees of responsibility in the field of biomedicine and, especially, of prenatal genetic diagnosis. The author comes to the …

Acute Haemolysis In Childhood Falciparum Malaria, H. Ekvall, P. Arese, F. Turrini, K. Ayi, F. Mannu, Zul Premji, A. Bjorkman

Pathology, East Africa

Acute haemolysis associated with clinical episodes of high-level Plasmodium falciparum parasitaemia was studied in 20 children from an holoendemic area (coastal Tanzania). The change in blood haemoglobin (Hb) concentration ranged from -46 to +5 g/L during the 72-h observation period and was linearly related to maximum parasitaemia. Balance studies between loss of blood Hb, increase in plasma Hb and appearance of Hb in the urine indicated that extravascular clearance of red cells was the predominant mode of erythrocyte clearance. Most subjects, however, showed minor signs of intravascular haemolysis. The plasma Hb was ≪1% of blood Hb and haemoglobinuria was detected …

Chemical Constituents Of Desmos Dumosus, Roxb., Mazdida Sulaiman

Student Works (2000-2009)

The chemical content of the 'leaves and bark of Des mos dumosus has been carried out in this study. The leaves yielded nine isoquinoline type of alkaloids and two flavones. The isoquinoline alkaloids isolated were pronuciferine 37, stepharine 39, nomuciferine 40, (-) - 3 - hydroxynomuciferine 41, norlirioferine 42, asimilobine 43, liriodenine 44, lysicamine 45 and O - methylmoschatoline 46. The flavones were 5 - hydroxy - 6,7 - dimethoxyflavone 47 and 5 - hydroxy - 7,8 - dimethoxyflavone 48. The same flavones, 47 and 48 and the alkaloids 45 and 46 were also present in the bark of this …

An Enzymatic Method For The Measurement Of Magnesium, Joseph Murphy

Theses

Magnesium is quantitatively the most important intracellular divalent cation (4), and has been found to serve in a wide range of enzymatic reactions (2). Studies have shown that up to ten percent of hospital patients may have hypomagnesaemia (6).

Atomic absorption spectrophotometry (AAS) under highly specified conditions is the de facto reference method for magnesium measurement but only about ten per cent of laboratories routinely use this method (4). This is because AAS is time-consuming, requires specialised equipment and a certain level of expertise, and may be hazardous due to the use of inflammable gases. Colourimetric methods e.g. calmagite are …

The Pineal Gland, Via Melatonin, Protects Dna, Coordinates The Endocrine System With The Immune System And Controls The Timing Of Reproduction, Craig L. Anthony

Theses and Dissertations

The pineal gland secretes the hormone melatonin (n-acetyl-5-methoxytryptamine) with a circadian rhythm. This secretion's rhythm becomes disrupted with age. When melatonin secretion is decreased with advanced age, the immune, endocrine and reproductive systems fail to function optimally. Melatonin possesses lipophilic and anti-oxidant properties, providing it with access to nuclei. Melatonin protects the DNA, preventing cancerous mutation. Hippocampal degeneration and age increase and prolong the adrenocortical responses to stress. Melatonin supplementation reduces the prolonged exposure to harmful hormones.

A Comparative Study Of Murine Mast Cell Progenitors, Shirley K. Desimone

Theses and Dissertations

This thesis is a comparative study of variables affecting differentiation and proliferation of progenitor cells from various embryonic and fetal tissue sites as they differentiate into mast cells. Embryonic stem cells from gestation day 4.5 (d4.5) differentiated exclusively into mast cells when cultured in semi-solid media with stem cell factor (SCF) and Interleukin-3 (IL-3). The same was true of d8-1 1 yolk sac cells and d8-1 1 cells from the embryo itself. However, culture with SCF and IL-3 of cells from dl4 fetal livers differentiated into mast cells, cells of the erythrocyte lineage and a few "macrophages" which may have …

Development And Testing Of An Assessment Tool For Integrated Learning, Z. Naqvi, R. Ahmed, Bushra Jamil

Department of Medicine

Objective: Development of integrated questions for undergraduate medical students and assessing students’ capability to retain and apply basic concepts in an integrated way.
Method: Multiple choice questions, attempting to probe understanding and application of different concepts, affiliated with different subjects and topics, were developed. As a pilot these were administered to the students of third year and final year at the end of their certifying examinations as a mock test. The following year these questions were introduced in the continuous assessments and subsequently the certifying examinations (in third year) as 33% of the whole examination. Difficult indices, item analysis and …

Cancer-Induced Fatigue And Skeletal Muscle Wasting: The Role Of Exercise, Sadeeka Al-Majid, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Fatigue is the most frequently reported symptom by cancer patients. Many of these patients perceive fatigue as the most distressing symptom associated with their illness because it imposes limitations on their physical activity level. Skeletal muscle wasting, which occurs as part of cancer cachexia, is one of the mechanisms that contribute to fatigue. Cancer induced skeletal muscle wasting may occur despite normal food intake and is not prevented by nutritional supplementation. Evidence suggests that endurance exercise ameliorates cancer-related fatigue. There is no compelling evidence to support that exercise induced reduction in fatigue is related to preservation of muscle mass. Resistance …

Resistance Exercise Training Attenuates Wasting Of The Edl Muscle In Mice Bearing The Colon-26 Adenocarcinoma, Sadeeka Al-Majid, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Progressive wasting of skeletal muscle is a significant side effect of malignancy. Perturbations in protein metabolism contribute to this state of wasting. Resistance exercise increases protein synthesis and mass of healthy muscles and counteracts muscle wasting associated with several catabolic conditions. It is not known whether resistance exercise training can counteract cancer-induced muscle wasting. This study examined the effect of resistance exercise training on muscle mass and protein content in 9 mice bearing the colon-26 adenocarcinoma. The dorsiflexor (extensor digitorum longus [EDL] and tibialis anterior) and plantar flexor (soleus, plantaris, and gastrocnemius) muscles of 1 leg of the tumor-bearing and …

Central Chemosensitivity, Sleep, And Wakefulness, E. E. Nattie, A Li

Dartmouth Scholarship

No abstract provided.

Epidemiological Features Of Aplastic Anaemia In Pakistan, Salman Adil, G. N. Kakepoto, Mohammad Khurshid, I. A. Burney

Department of Pathology and Laboratory Medicine

Objective: To complete the data on the demographic features of patients diagnosed to have aplastic anemia at a single institution over a 7.5 years period. Methods: Demographic information was retrieved from the patients medical records retrospectively as well as prospectively of those patients who presented with features of aplastic anaemia. Their diagnosis was confirmed by performing a complete blood count and bone marrow trephine.
Results: One hundred and forty four patients were diagnosed to have aplastic anemia; there were 106 males and 38 females. Their ages ranged from 2 to 75 years, with a median of 17 years, …

History, Culture And Alcohol: Drinking Patterns In Poland And Australia, Barbara Wolska

Theses: Doctorates and Masters

It is a widely held view in Poland that for centuries those in power have promoted heavy drinking among their subjects in order to achieve their various goals and that this contributed to the development of Polish drinking patterns. There is some empirical evidence that the political economy of alcohol in Poland promoted heavy drinking among the Polish population. Drinking alcohol in Poland was an important aspect of social situations. The most popular beverage was vodka(s). Social pressure to drink in the extreme was attributed to the tradition of hospitality. Cultural norms encouraged very heavy drinking among men and imposed …

A Report On Nurses' Response To Occupational Injuries And Exposures To Hazards In A Californian Community Hospital, Sandra Kilminster-Binder

Theses: Doctorates and Masters

This study set out to determine the reasons for underreporting of occupational injuries and exposures in the American health care environment. A cross sectional survey was used to report the responses and opinions of nurses who failed to report all occupational injuries and exposures, and the type of injuries that are least likely to be reported. The participants were a random sample of Registered Nurses employed in a California Health Care Center, who responded to a simple self-reporting questionnaire. The study revealed that the majority of occupational injuries, accidents and exposures by this group in the previous twelve month period …

A Pilot Study Of An Employee Developed Observational Tool As A Valid And Reliable Measure Of Organisational Safety, Matthew Wallace

Theses: Doctorates and Masters

Given the increasing high social and economic costs of occupational injury and illness to the Australian community, identification of initiatives to reduce the burden is urgently required. Paramount to reversing this trend is the need to identify and address the causes of the injury and illness. Employee involvement in occupational health and safety has for some time been espoused as an essential element in any occupational health and safety program, but its relationship with safety performance still remains unexplored. Although various theories suggest that the involvement of employees will increase their sense of ownership, there is little research to suggest …

The Effect Of Prescribed And Preferred Intensity Exercise On The Relationship Between Self-Efficacy And Perceived Exertion In Older Adults, Keith R. Scotson

Theses: Doctorates and Masters

This study was concerned with acute responses to exercise in people over the age of 50 (N = 80). In particular the relationship between Self-efficacy and perceived exertion during exercise at workloads (a) based on a target heart rate (prescribed intensities) and (b) based on participant preference (preferred intensities) were observed. Perceptual (perceived exertion), Self-efficacy and heart rate responses of low active older participants engaged in either walking or cycle ergometer exercise at preferred and prescribed intensities were also reported. Significant inverse correlations were observed between pre and post exercise Self-efficacy and perceived exertion during acute exercise at prescribed intensities …

Genetic Variation And Disease In The Roma (Gypsies), David J. Gresham

Theses: Doctorates and Masters

The Roma (Gypsies) are a European people composed of a mosaic of culturally heterogeneous populations. Linguistic analyses point to their origins in the Indian subcontinent. Cultural diversity in extant Romani populations suggests that they are descended from a mixture of Indian populations. Previous population genetic studies of the Roma have supported this claim by demonstrating the genetic heterogeneity of Romani populations. More recently, medical genetic research has detected identical founder mutations in separated Romani populations, which provides evidence of their relatedness. In this thesis, the genetic heritage of the Roma and its significance for genetic disease and research is investigated. …

Like A Banana Tree : Towards A Model Of Children In Disasters : An Exploration Of An Anthropological Problem, Jennie Anne Ricarda Marten

Theses : Honours

There is currently an emerging literature on the anthropology of disasters, and also an emergent literature on the new anthropology of childhood and children. Despite an extensive search, no significant body of literature on the anthropology of children in natural event based disasters could be found. A central focus of this thesis will be interrogate this gap through a documentary search, to ascertain what factors might influence the absence of children in the anthropology of disasters. To achieve this, the study defines and conceptualizes both the anthropology of disasters and the anthropology of children. Recent research shows that children are …

The Effect Of Moderate +Gz Force On The Cervical Spine Bone Mineral Density In Raaf Pc-9 Pilots, Meghan C. Grant

Theses : Honours

Previous research on exercise and bone mineral density (BMD) has established that increases in BMD are site specific, responding to unusual strain and particularly to high magnitude loading. The positive Gz forces generated during high performance flying provide all three variables. Naumann, Bennell and Wark (2000) investigated the effects of moderate gravitational force on the BMD of fighter pilots. The pilots in this study had significant increases in BMD and bone mineral content (BMC) for the thoracic spine, pelvis and total body. However, it is now suspected that the cervical spine, which was unable to be analysed at that time …

The Effects Of Ageing On The Myocardium, Alana J. Mason

Theses : Honours

Investigating the causes of ageing on the myocardium is especially important for the future health of Australia's ageing population, which is increasing due to increased life expectancy (AIHW, 1999). Cardiovascular disease is currently Australia's greatest health problem ( AIHW, 1999), and since the aged population is most commonly affected by this disease (HSVD, 1999), investigating the causes of ageing of the myocardium and the predisposing factors of cardiovascular disease is important for the future health of Australia's ageing population. In this study, male and female Wistar rats [young (11 = 8, aged 12-30 weeks old), middle aged (11 = 6, …

Nursing Students' And Clinical Teachers' Perceptions Of Effective Teacher Characteristics, Shirley Chow

Theses: Doctorates and Masters

Instructional and organisational strategies can improve students' transfer of knowledge and skill to the workplace. Constraints on transfer include: 1. a shortage of teachers who can build transfer inlo programmes; and 2. time span (interval) between teaching of the task and transfer of learning. Fifteen nursing students and five clinical teachers from a university in Western Australia participated in the initial qualitative component of the study. These students and teachers were asked to list effective clinical teachers' behaviours which were then compared with beaviours listed in the Rauen's Clinical Instructor Characteristics Rating Scale (1974). Using a modified Rauen's Scale, 200 …

The Translational Regulation Of Lipoprotein Lipase In Diabetic Rats Involves The 3′-Untranslated Region Of The Lipoprotein Lipase Mrna, Gouri Ranganathan, Chunling Li, Philip A. Kern

Clinical and Translational Science Faculty Publications

Adipose tissue lipoprotein lipase (LPL) activity is decreased in patients with poorly controlled diabetes, and this contributes to the dyslipidemia of diabetes. To study the mechanism of this decrease in LPL, we studied adipose tissue LPL expression in male rats with streptozotocin-induced diabetes. Heparin releasable and extractable LPL activity in the epididymal fat decreased by 75-80% in the diabetic group and treatment of the rats with insulin prior to sacrifice reversed this effect. Northern blot analysis indicated no corresponding change in LPL mRNA levels. However, LPL synthetic rate, measured using [³⁵S]methionine pulse labeling, was decreased by 75% in …

Medical Education Digest, Vol. 2 No. 6 (December 15, 2000), Nova Southeastern University

Medical Education Digest

No abstract provided.

Louisiana State University Health Sciences Center - 2000 - Fall Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 2000 Fall Commencement of LSU Health Sciences Center - New Orleans held December 14, 2000.

Predicting The Local Dynamics Of Epizootic Rabies Among Raccoons In The United States, James E. Childs, Aaron T. Curns, Meghan E. Dey, Leslie A. Real, Lisa Feinstein, Ottar N. Bjørnstad, John W. Krebs

Zoonotics and Wildlife Disease: Publications

Mathematical models have been developed to explore the population dynamics of viral diseases among wildlife. However, assessing the predictions stemming from these models with wildlife databases adequate in size and temporal duration is uncommon. An epizootic of raccoon rabies that began in the mid-Atlantic region of the United States in the late 1970s has developed into one of the largest and most extensive in the history of wildlife rabies. We analyzed the dynamics of local epizootics at the county level by examining a database spanning more than 20 years and including 35,387 rabid raccoons. The size, number, and periodicity of …

Acknowledgements, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Mcnair Research Journal Authors' Photos, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Full Issue, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Professional Expertise Of Community-Based Occupational Therapists, Lori Ann Madaus Lemorie

Masters Theses

Occupational therapists are increasingly practicing in community-based settings. Due to changes in the health care system, the need for defining roles, and explaining what a profession can contribute to health care has been highlighted. The major goal of this study was to identify job roles, job skills, and professional expertise of community-based therapists. The Community Practice Project survey was mailed to 200 AOTA registered community-based therapists. A response rate of 42% was achieved. The results provided a profile of the typical community-based therapist. Principal roles, job skills, and areas of professional expertise were also identified. The adequacy of educational preparation …

Developmental, Psychosocial, And Economic Predictors Of Healthy Newborns In Michigan’S Teenage Pregnancies, Cheryl Lauber

Dissertations

Teenage pregnancy is a critical health indicator. Using a risk reduction model, this study examined the relationship between the characteristics o f the teenage mother i and her newborn. The research questions were: ( I) what risk factors are associated with poor birth outcomes, (2) is addressing each factor the best way to reduce the risk, and (3) has the overall risk changed as the birth rate has declined? Developmental, psychosocial and economic risks were identified as independent variables, while age and race were mediators.

Combining the birth certificate records of women under age 20 from 1990 through 1997 resulted …

Glucocorticoid Regulation Of Insulin Like Growth Factor Binding Protein-5 Gene Transcription In Human Osteoblasts, Xiaoying Wang

Loma Linda University Electronic Theses, Dissertations & Projects

Glucocorticoids (GCs) inhibit bone formation in vivo and inhibit osteoblast proliferation and collagen synthesis in vitro. These effects may be mediated by alterations in the insulin-like growth factor (IGF) system. In the present study of normal human osteoblast-like (HOB) cells, we tested the hypothesis that dexamethasone (Dex) inhibits the expression of IGF binding protein-5 (IGFBP-5). Dex decreased IGFBP-5 mRNA levels to 54% of control after 4 hr. Dex did not modify the decay of IGFBP-5 mRNA in transcriptionally arrested osteoblast cells. Dex decreased IGFBP-5 hnRNA levels to 67% of control after 2 hr, and the activity of the human IGFBP- …