Digital Commons Network^™

Serotyping Group B Streptococci In A Small Community Hospital: An Analysis Of Distribution And Site Of Isolation, Jennifer M. Smith, Jason A. Rexroth, David G. Chaffin, Susan H. Jackman

Biochemistry and Microbiology

Objective: To determine the prevalence and site of isolation of different serotypes of group B streptococcus (GBS) colonization or infection at a small community hospital.

Methods: GBS isolates were obtained from a small community hospital and were then serotyped as la, Ib, II, III, IV, V or non-typeable. Hospital records were reviewed for patient sex, age and pregnancy status as well as the site of GBS isolation.

Results: GBS serotypes Ia, III and V were most common and accounted for over 60% of the total number of isolates. Serotype Ia was most prevalent in reproductive-age females, while serotypes V and …

Teaching Research Ethics: An Institutional Change Model, Michael Pritchard

Center for the Study of Ethics in Society Papers

Paper presented to the center, April 2002.

Research Ethics, Wmu Center For The Study Of Ethics In Society

Center for the Study of Ethics in Society Papers

Papers published by the center, April 2002.

Center For Psychology Studies Newsletter - Spring 2002, Nova Southeastern University

Center for Psychological Studies Newsletter

No abstract provided.

Role Of Disulphide Bond Formation In Folding, Secretion, And Assembly Of Human Chorionic Gonadotropin Subunits., Elliott Bedows, Ryan J. Darling, Jason A. Wilken, Simon Sherman

Journal Articles: Eppley Institute

Ability of a glycoprotein hormone to fold and assemble correctly is an essential requirement for the attainment of its biological activity . Cells have a quality control system to assure that when proteins of the endoplasmic reticulum mi sfold or fail to assemble correctly they do not exit the cell. But human chorionic gonadotropin (hCG) is an exception to this rule as is illustrated by the following observations. First, both hCG subunits are secreted efficiently as unassembled monomers. Second, some mis(un)folded forms of hCG-β can be efficiently secreted from cells that do not facilitate the secretion of other misfolded proteins. …

Relationships Between A Quaternary Model Of Psychological Type Processes And Defense Mechanism Clusters, Kathryn Elizabeth Kelly

Doctoral Dissertations

This study examined the relationships between two psychological type dimensions (Extraversion-Introversion and Thinking-Feeling) and defense mechanism preferences. Psychological Type Theory was used as a conceptual framework for the generation of hypotheses. Specific hypotheses between the two psychological type dimensions and defense mechanism preferences were tested. Further, Extraversion-Introversion and Thinking-Feeling were combined, resulting in the formation of a quaternary personality model consisting of four groups (Introverted Thinking, Introverted Feeling, Extraverted Thinking, and Extraverted Feeling). Hypotheses that certain quaternary groups would display specific relationships with defense mechanism preferences were tested. To test hypotheses, 223 university students were administered the Myers-Briggs Type Indicator …

Flight Physician - April, 2002, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A sixteen page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Effectiveness Of Current Therapy Of Bacterial Vaginosis, Petya M Andreeva, Hatim A. Omar

Pediatrics Faculty Publications

The study was conducted in order to evaluate effectiveness of the treatment of bacterial vaginosis (BV) with different therapeutic regimes according to recommendations of the World Health Organization (WHO). During a one-year period (February 2000-February 2001) the Sexually Transmitted Diseases (STD) Center was visited by 482 women aged 14-51. The diagnosis of BV was established by standard methods: Amsel's clinical criteria and Gram stain of vaginal discharge. The first-line treatment was oral Metronidazole 2 g single dose. Second line was Metronidazole 500 mg twice daily orally for 7 days or oral Clindamycin 300 mg twice daily for seven days. BV …

A Study Of Quality Of Life Issues In Community-Dwelling Elders, Kimberly S. Mcclane Phd

Dissertations

In the year 2000, there were approximately 35 million people in the United States who were 65 years of age or older, a ten-fold increase since 1900. The growth of this population has presented opportunities and challenges to American society. Health care needs, physical changes of aging, and the allocation of health care resources are several of the issues that need to be addressed (Federal Interagency Forum on Aging-Related Statistics, 2000). Quality of life measurement tools have been used to assess the health and social needs of aging people both in the United States and internationally since their conception in …

Unlv Magazine, Barbara Cloud

UNLV Magazine

No abstract provided.

Type 4 Pilus Biogenesis And Type Ii-Mediated Protein Secretion By Vibrio Cholerae Occur Independently Of The Tonb-Facilitated Proton Motive Force, Niranjan Bose, Shelley M. Payne, Ronald K. Taylor

Dartmouth Scholarship

In Vibrio cholerae, elaboration of toxin-coregulated pilus and protein secretion by the extracellular protein secretion apparatus occurred in the absence of both TonB systems. In contrast, the cognate putative ATPases were required for each process and could not substitute for each other.

Novel Pathways Associated With Bypassing Cellular Senescence In Human Prostate Epithelial Cells, Steven R. Schwarze, Samuel E. Deprimo, Lisa M. Grabert, Vivian X. Fu, James D. Brooks, David F. Jarrard

College of Nursing Faculty Research and Publications

Cellular senescence forms a barrier that inhibits the acquisition of an immortal phenotype, a critical feature in tumorigenesis. The inactivation of multiple pathways that positively regulate senescence are required for immortalization. To identify these pathways in an unbiased manner, we performed DNA microarray analyses to assess the expression of 20,000 genes in human prostate epithelial cells (HPECs) passaged to senescence. These gene expression patterns were then compared with those of HPECs immortalized with the humanPapillomavirus 16 E7 oncoprotein. Senescent cells display gene expression patterns that reflect their nonproliferative, differentiated phenotype and express secretory proteases and extracellular matrix components. A …

The Flame, Spring 2002, Mennonite College Of Nursing

The Flame (1985-present)

The Flame is a newsletter of Illinois State University's Mennonite College of Nursing

Chironian Spring/Summer 2002, New York Medical College

The Chironian

No abstract provided.

A Study To Examine The Attitudes And Perceptions Of Saudi Women In The United States And Canada Toward Exercise And Physical Activity, Tawfeeq E. Al-Bakry

Human Movement Studies & Special Education Theses & Dissertations

This study is an examination of the knowledge and perceptions of Saudi women in the United States and Canada in regard to exercise and physical activity. No studies on exercise, physical activity or sport for women in Saudi Arabia were found in the literature.

This study focused on ascertaining knowledge of Saudi women regarding physical and psychological benefits of exercise and physical activity. Furthermore, this study investigated the barriers that limit Saudi women from participating in exercise and physical activity. The population for this study included Saudi women who are associated with Saudi clubs and student organizations in the United …

A Naturalistic Investigation Into The Processes And Themes Of Recovery From Chemical Dependency, Mark Thomas Blagen

Theses and Dissertations in Urban Services - Urban Education

The research on recovery from alcoholism and drug addiction has generally focused on the causes of relapse. Although the study of the causes of relapse is an important endeavor, the results of this focus remain inconclusive. Understanding the process and themes of recovery is also an important question that remains a significant challenge.

This study attempts to explain, in part, why it is that one person can have many relapse indicators and still thrive in recovery, while another who has multiple layers of support and opportunity for recovery, succumbs to addiction. This study also attempts to determine if and how …

Determination Of Nuclear Factor-Kappa B Activation In Cultured Renal Epithelial Cells And Cardiac Myocytes Exposed To Cocaine And Morphine, David Angeles Tiangco

Biological Sciences Theses & Dissertations

Nuclear factor-kappa B (NF-kB) is an important transcription factor that participates in the genetic regulation of inflammation in many tissues. Cocaine and heroin are drugs of abuse associated with renal and cardiac pathology. The purpose of this study was to test the hypothesis that exposure to cocaine or morphine (a metabolite of heroin) would activate NF-kB in renal epithelial cells (COS-7) and cardiac myocytes (H9c2) grown in culture. COS-7 and H9c2 cells were co-transfected with an experimental reporter specific for NF-kB activation and a control reporter with constitutive activity. A dual-luciferase assay was used to determine levels of NF-kB activation …

Production Of A Monoclonal Antibody Against Benzo[Α]Pyrene Diol Epoxide Dna Adducts, Brian Peden Austin

Chemistry & Biochemistry Theses & Dissertations

Benzo[α]pyrene is a ubiquitous pollutant produced from the incomplete combustion of organic material such as fossil fuels. It is found in the workplace, urban air, drinking water, and the food supply. Recently, it has been proposed that benzo[α]pyrene may be the causative agent in the formation of lung adenocarcinomas among some Taiwanese women exposed to cooking oil fumes without adequate ventilation. In this study, calf thymus DNA was modified in vitro with benzo[α]pyrene-diol epoxide (BPDE) to a level consistent with that found in biological samples. This DNA of low modification was used as an immunogen in the production of a …

Prostate Specific Membrane Antigen (Psma): Immunoassay Development And Characterization Of Transcriptional Regulation, Zhen Xiao

Theses and Dissertations in Biomedical Sciences

Prostate cancer (PCA) is the most common cancer and the second leading cause of death among American men. The high mortality is greatly attributed to the lack of early detection tools and effective treatment for metastasis and relapses. Biomarkers that can discriminate benign from malignant tumor and signal the development of androgen independent and metastatic tumor are needed. A biomarker designated prostate specific membrane antigen (PSMA) has the potential to fulfill this need. The objective of this study is to develop a clinically useful immunoassay for quantitation of serum PSMA and to study the molecular mechanism underlying the upregulation of …

Western Michigan University Occupational Therapy Department Web Page, Holly Pietrzak, Melissa Byrne

Honors Theses

Website designed for WMU's Occupational Therapy department.

Genetic Testing: A Cautionary Tale Of Foster And Pre-Adoptive Children, Janet Farrell Smith

New England Journal of Public Policy

Genetic testing of children in the foster care and pre-adoptive stage may be thought to facilitate child placement and satisfy prospective parents’ need to know. But, the policy analysis in this paper recommends great caution, especially given eugenic attitudes in the history of adoption and the risk of creating a second tier of un-adoptable children. Testing should be done only when two conditions are satisfied: test information is medically useful for childhood onset diseases; test information supports and does not diminish the child’s access to present and future healthcare (or the child’s future insurability). Public policy needs to make a …

Environmental Public Health Awaits Rediscovery, Anthony Robbins, Phyllis Freeman

New England Journal of Public Policy

Preventing environmental exposures that threaten human health remains among the best but least attended to opportunities to improve everyone’s health. For more than a decade, medical care concerns, exacerbated by voracious competition among medical empires and the implacably growing number of uninsured, have often been misconstrued as constituting a complete agenda for health system reform. The authors explain the predicament from an historical perspective — how defining events moved U.S. health policy away from protecting the public against dangerous exposures toward unrealistic expectations that doctors will fix whatever goes wrong, at least for individuals with ample medical insurance. They explain …

Institutional Denial About The Dark Side Of Law School, And Fresh Empirical Guidance For Constructively Breaking The Silence, Lawrence S. Krieger

Journal of Legal Education

No abstract provided.

Fluorescent Probes For Monitoring Virus Fusion Kinetics: Comparative Evaluation Of Reliability, Isabel Nunes-Correia, Ana Eulálio, Shlomo Nir, Nejat Düzgüneş, João Ramalho-Santos, Maria C. Pedroso De Lima

All Dugoni School of Dentistry Faculty Articles

Fluorescence assays for viral membrane fusion employ lipidic probes whose kinetics of fluorescence dequenching should mimic the actual kinetics of membrane merging. We examined the fusion of influenza virus with CEM cells, erythrocyte ghosts or liposomes by monitoring the fluorescence dequenching of each one of the three probes, octadecylrhodamine B chloride (R18), N-(lissamine rhodamine B sulfonyl)phosphatidylethanolamine (Rh-PE), or rac-2,3-dioleoylglycerol ester of rhodamine B (DORh-B), inserted into the virus membrane. Experimental conditions were designed to allow a clear distinction between membrane mixing and non-specific probe transfer. Fluorescence dequenching observed with Rh-PE was much slower than with R18, unless a particular experimental …

Ube1l Is A Retinoid Target That Triggers Pml/Rarα Degradation And Apoptosis In Acute Promyelocytic Leukemia, Sutisak Kitareewan, Ian Pitha-Rowe, David Sekula, Christopher H. Lowrey, Michael J. Nemeth, Todd R. Golub, Sarah J. Freemantle, Ethan Dmitrovsky

Dartmouth Scholarship

All-trans-retinoic acid (RA) treatment induces remissions in acute promyelocytic leukemia (APL) cases expressing the t(15;17) product, promyelocytic leukemia (PML)/RA receptor α (RARα). Microarray analyses previously revealed induction of UBE1L (ubiquitin-activating enzyme E1-like) after RA treatment of NB4 APL cells. We report here that this occurs within 3 h in RA-sensitive but not RA-resistant APL cells, implicating UBE1L as a direct retinoid target. A 1.3-kb fragment of the UBE1L promoter was capable of mediating transcriptional response to RA in a retinoid receptor-selective manner. PML/RARα, a repressor of RA target genes, abolished this UBE1L promoter activity. A hallmark of …

Cd46 Is Phosphorylated At Tyrosine 354 Upon Infection Of Epithelial Cells By Neisseria Gonorrhoeae, Shaun W. Lee, Robert A. Bonnah, Dustin L. Higashi, John P. Atkinson, Sharon L. Milgram, Magdalene So

Open Access Publications

No abstract provided.

Ada News - 03/18/2002, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Method For Storing And Retrieving Sequential Information, Philip W. Landfield, Olivier Thibault

Pharmacology and Nutritional Sciences Faculty Patents

A method and design is provided for distributing and storing sets of temporally ordered information in a systematic and sequential fashion. This method is based on a model of how the brain functions in the distribution and storage of temporally ordered memories, but it can also be applied to the design of new biological, electronic or optical devices. These devices may be used in the testing and development of new therapeutic drugs, in the detection of toxic agents or impaired performance, or in the development of new industrial and consumer devices in which the orderly storage of sequential information is …

Methods And Compositions For The Treatment Of Psoriasis, Kenneth A. Foon, Malaya Chatterjee

Microbiology, Immunology and Molecular Genetics Faculty Patents

This invention provides methods of treating psoriasis which entail eliciting an immune response in an individual against an antigen aberrantly expressed in psoriatic tissue, such as a ganglioside, in an individual. The anti-ganglioside immune response is elicited by administration of an antigen such as a ganglioside, an anti-idiotype moiety for a ganglioside, or a polynucleotide encoding an anti-idiotype moiety. Also described is a strategy for developing additional compositions for psoriasis. The compositions elicit an immunological response against a target antigen present on psoriatic tissue, which in turn can be detected using antibody affinity-purified from the serum of the treated subject. …

How Should Governments Address High Levels Of Natural Radiation And Radon--Lessons From The Chernobyl Nuclear Accident And Ramsar, Iran, S. M. Javad Mortazavi, M. Ghiassi-Nejad, Azam Niroomand-Rad, P. Andrew Karam, John R. Cameron

RISK: Health, Safety & Environment (1990-2002)

The authors discuss the high levels of natural background radiation in Ramsar, Iran, and offer data indicating that this has had little effect on the health of Ramsar's inhabitants. The authors then examine the implications their research could have for public health policy.