Digital Commons Network^™

Pathogen- Or Elicitor-Inducible Transcription Regulatory Element From The Tobacco 5-Epi-Aristolochene Synthase Gene And Plants Transformed Therewith, Joseph Chappell, Shaohui Yin, Catherine Cornett

Pharmaceutical Sciences Faculty Patents

A tobacco epi-5-aristolochene synthase transcriptional regulatory element functional in plants, plant tissue and in plant cells for pathogen inducible gene expression and a method for increasing the transcriptional expression of downstream genetic information in plants, plant tissue and plant cells are disclosed.

Louisiana State University Health Sciences Center - 2003 - 124th Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 124th Commencement of LSU Health Sciences Center - New Orleans held August 9, 2003.

Vegf164-Mediated Inflammation Is Required For Pathological, But Not Physiological, Ischemia-Induced Retinal Neovascularization, Susumu Ishida, Tomohiko Usui, Kenji Yamashiro, Yuichi Kaji, Shiro Amano, Yuichiro Ogura, Tetsuo Hida, Yoshihisa Oguchi, Jayakrishna Ambati, Joan W. Miller, Evangelos S. Gragoudas, Yin-Shan Ng, Patricia A. D'Amore, David T. Shima, Anthony P. Adamis

Ophthalmology and Visual Science Faculty Publications

Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted. During pathological neovascularization, both the absolute and relative expression levels for VEGF₁₆₄ increased to a greater degree than during physiological neovascularization. Furthermore, extensive leukocyte adhesion was observed at the leading edge of pathological, but not physiological, neovascularization. When a VEGF₁₆₄-specific neutralizing aptamer was administered, it potently suppressed the leukocyte adhesion and pathological neovascularization, whereas it had little or no effect on physiological neovascularization. In parallel experiments, genetically altered VEGF_{164 …}

Dynamic Changes In The Osteoclast Cytoskeleton In Response To Growth Factors And Cell Attachment Are Controlled By Beta-3 Integrin, Roberta Faccio, Deborah V. Novack, Alberta Zallone, F. Patrick Ross, Steven L. Teitelbaum

Open Access Publications

No abstract provided.

All The News That’S Fat To Print: The American "Obesity Epidemic" And The Media, Natalie Boero

Faculty Publications, Sociology

Increasingly the term epidemic is being used to describe the current prevalence of fatness in the United States. Skyrocketing rates of obesity among all groups of Americans, particularly children, the poor, and minorities, have become a major public health concern. Indeed, it is difficult to open a newspaper or magazine without encountering a discussion of the expanding American waistline and the health problems associated therewith. In this paper I use 751 New York Times articles on obesity to examine the media construction of the obesity epidemic. I show that there is not one dominant discourse (i.e. medicine) constructing this epidemic, …

Knowledge Of Cardiovascular Disease Risk Factors And Perception Of Risk In Women, Kimberly Kuykendall-Marlar

MSN Research Projects

More women than men are dying of cardiovascular disease. The misconception persists that heart disease is a "man's disease" and not an urgent health care issue for women. In the United States, heart disease kills more women than all cancers combined. In 1997, 228,679 women died due to cardiovascular disease, and 41,443 women died from breast cancer. Yet, women are still not assessed effectively for their risk factors for cardiovascular disease; therefore, women are under-diagnosed and under-treated for this disease. The purpose of this study was to evaluate women's knowledge of cardiovascular disease risk factors, assess their perception of risk, …

Information Interface - Volume 31, Issue 2 - August/September 2003, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users. Includes articles on computer network improvements, PDA resources, the annual book sale, and database search tips.

What's New In Spine Surgery, Jack E. Zigler, Paul A. Anderson, Scott D. Boden, Keith H. Bridwell, Alexander R. Vaccaro

Open Access Publications

No abstract provided.

The Relationship Among Lifestyle, Self-Esteem, And Body Mass Index In Children, Wanda Stroupe

MSN Research Projects

Current research demonstrated that childhood obesity has dramatically increased, especially in the rural South. Current research suggests that 25% of children are currently obese while there has been a 75% increase in relative obesity in children over the past three decades. A correlational, descriptive design was utilized to examine the following hypothesis : There will be a significant correlation among the variables of selfesteem, lifestyle, and body mass index in children. The purpose of this study was to determine if a significant correlation exists among body mass index, lifestyles, and self-esteem in children. Erickson, Tomlin, and Swain's Modeling-Role Modeling Theory …

Facilitators And Barriers To Compliance Of Middle-Aged Hypertensive African-American Adults, Monica Jones

MSN Research Projects

Hypertension is a major risk factor for cardiovascular disease, such as atherosclerosis, heart attack, and stroke. Surveys indicate that one out of four Americans has high blood pressure. It occurs more often in men than women and is most common in African-American males. Despite the fact that there are constantly improving treatments available, many hypertensive patients are noncompliant with prescribed treatment plans. The focus of this descriptive study was to identify facilitators and barriers to compliance in hypertensive middle-aged African American adults. Pender's Health Promotion Model served as the theoretical framework. The research question guiding this study was as follows: …

Primary Care Providers' Prescribing Practices Of Selective Serotonin Reuptake Inhibitors, Ginger Dowell

MSN Research Projects

The use of selective serotonin reuptake inhibitors (SSRIs) is rapidly growing among the general population. Researchers have identified only minimal empirical data regarding the SSRI-prescribing practices among primary care providers. The focus of this descriptive study was to explore SSRI-prescribing practices of primary care providers. Benner's (1984) Novice to Expert Model was the theoretical framework used to conduct this study. The research questions used to guide the research were as follows: What factors influence the prescribing practices of primary care providers regarding SSRIs? And what are the perceived competency levels of primary care providers in prescribing SSRIs? The research design …

Primary Care Family Nurse Practitioners’ Practices O F Assessment For The State O F Thriving Among Community-Based Elders, Judy Labonte

MSN Research Projects

The increasing life span of people within the developed world may produce major health problems for the elder. These health problems lead to premature declines in function and cognition. Many healthcare professionals do not recognize these declines until the need for institutionalized care is urgent. Research has demonstrated that healthcare professionals either fail to recognize or address these declines, contributing to poor outcomes for the elder and the exponential rise in healthcare expenses o f the Medicare and Medicaid funds. This exploratory, descriptive study was designed to examine the level of assessment by primary care family nurse practitioners (FNPs) for …

Identification Of Common Variables Among A Select Group Of Children With Autism, Angela Yarbrough

MSN Research Projects

Autism has become the topic of much recent debate. Autism is a serious, lifelong developmental disability characterized by significant impairments in reciprocal social interactions and communication skills, as well as a restricted and repetitive pattern of interests and or behaviors (American Psychiatric Association, 1994). Minimal information is available about the prevalence or causes of the disorder in the United States. The purpose of this descriptive study was to find and identify common variables among a select group of children diagnosed with autism. Roger's Science of Unitary Human Beings served as the theoretical framework for this study. Rogers (1980) states that …

The Shape Parameter Of Liposomes And Dna-Lipid Complexes Determined By Viscometry Utilizing Small Sample Volumes, Yan Sun, X. Li, Nejat Düzgüneş, Y. Takaoka, S. Ohi, S. Hirota

All Dugoni School of Dentistry Faculty Articles

A minicapillary viscometer utilizing <0.5 ml of sample at a volume fraction of <0.1% is described. The calculated a/b of DPPC/DPPG multilamellar liposome was 1.14 as prolate ellipsoids and a/b of dioleoylpropyltrimethyl ammonium methylsulfate-DNA complex at a charge ratio of 4:1 (+/-) was 3.7 as prolate ellipsoids or 4.9 as oblate ellipsoids. The deviation of shape from perfect sphere is thus expressed quantitatively in more than two significant figures. In these measurement, the necessary amount of DNA is <0.5 mg.

An Interdisciplinary And Synthetic Approach To Ecological Boundaries, Mary L. Cadenasso, Steward T. A. Pickett, Kathleen C. Weathers, Susan S. Bell, Tracy L. Benning, Margaret M. Carreiro, Todd E. Dawson

Integrative Biology Faculty and Staff Publications

We introduce a collection of articles that proposes conceptual and methodological tools to advance the integrated study of ecological boundaries. A number of studies are germane to understanding the structure and function of boundaries over a wide array of ecological systems and scales. However, these studies have not been unified in a consistent theoretical framework. To integrate these seemingly disparate studies and to advance future research on boundaries, these articles present a common conceptual framework, a classification of the different types of boundaries and their potential functions, and statistical and modeling approaches that can be applied to a wide range …

Vital Signs, Fall 2003, Boonshoft School Of Medicine

Vital Signs

A twenty-eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, faculty profiles, and more.

Dose Coefficients For Radionuclides Produced In A Spallation Neutron Source, John P. Shanahan

Transmutation Sciences Physics (TRP)

Internal and external dose coefficient values have been calculated for 14 anthropogenic radionuclides which are not currently presented in Federal Guidance Reports No. 11, 12, and 13 or Publications 68 and 72 of the International Commission on Radiological Protection. Internal dose coefficient values are reported for inhalation and ingestion of 1 μm and 5 μm particulates along with the f1 values and absorption types for the adult worker. Internal dose coefficient values are also reported for inhalation and ingestion of 1 μm particulates as well as the f1 values and absorption types for members of the public. Additionally, external dose …

Inside Unlv, Gian Galassi, Carol C. Harter, Gale Sinatra

Inside UNLV

No abstract provided.

Computational Models For Diffusion Of Second Messengers In Visual Transduction, Harihar Khanal

Publications

The process of phototransduction, whereby light is converted into an electrical response in retinal rod and cone photoreceptors, involves, as a crucial step, the diffusion of cytoplasmic signaling molecules, termed second messengers. A barrier to mathematical and computational modeling is the complex geometry of the rod outer segment which contains about 1000 thin discs. Most current investigations on the subject assume a well-stirred bulk aqueous environment thereby avoiding such geometrical complexity. We present theoretical and computational spatio-temporal models for phototransduction in vertebrate rod photoreceptors, which are pointwise in nature and thus take into account the complex geometry of the …

Ccr5 Mediates Specific Migration Of Toxoplasma Gondii—Primed Cd8+ Lymphocytes To Inflammatory Intestinal Epithelial Cells, Souphalone Luangsay, Lloyd H. Kasper, Nicolas Rachinel, Laurie A. Minns

Dartmouth Scholarship

Toxoplasma gondii, an obligate intracellular parasite, can invade intestinal epithelial cells and elicit a robust Th1 immune response. In this model of intestinal inflammation, CD8⁺ intraepithelial lymphocytes (IELs) secrete transforming growth factor (TGF)-β, which appears necessary for the maintenance of homeostasis in the intestine. However, the mechanism responsible for the IEL migration to the inflamed intestine is still unclear.An in vitro coculture cell system was used to quantify the IEL attraction by an infected intestinal epithelial cell line (m-IC_cl2). We used CCR5-deficient mice to determine which chemokine receptor—chemokine interaction could be responsible for the recruitment of …

Adrenocortical Adenoma And Carcinoma: Histopathological And Molecular Comparative Analysis, A. Stojadinovic, M. F. Brennan, A. Hoos, A. Omeroglu, Denis H. Y. Leung, M. Dudas, A. Nissan, C. Cordon-Cardo, R.A. Ghossein

Research Collection School Of Economics

We compared histomorphological features and molecular expression profiles of adrenocortical adenomas (ACAd) and carcinomas (ACCa). A critical histopathological review (mean, 11 slides per patient) was conducted of 37 ACAd and 67 ACCa. Paraffin-embedded tissue cores of ACAd (n = 33) and ACCa (n = 38) were arrayed in triplicate on tissue microarrays. Expression profiles of p53, mdm-2, p21, Bcl-2, cyclin D1, p27, and Ki-67 were investigated by immunohistochemistry and correlated with histopathology and patient outcome using standard statistical methodology. Median follow-up period was 5 years. Tumor necrosis, atypical mitoses, and >1 mitosis per 50 high-power fields were factors that were …

The Virulence Activator Apha Links Quorum Sensing To Pathogenesis And Physiology In Vibrio Cholerae By Repressing The Expression Of A Penicillin Amidase Gene On The Small Chromosome, Gabriela Kovacikova, Wei Lin, Karen Skorupski

Dartmouth Scholarship

Activation of the tcpPH promoter on the Vibrio pathogenicity island by AphA and AphB initiates the Vibrio cholerae virulence cascade and is regulated by quorum sensing through the repressive action of HapR on aphA expression. To further understand how the chromosomally encoded AphA protein activates tcpPH expression, site-directed mutagenesis was used to identify the base pairs critical for AphA binding and transcriptional activation. This analysis revealed a region of partial dyad symmetry, TATGCA-N6-TNCNNA, that is important for both of these activities. Searching the V. cholerae genome for this binding site permitted the identification of a second one upstream of a …

Vocal Dose Measures: Quantifying Accumulated Vibration Exposure In Vocal Fold Tissues, Ingo R. Titze, Jan G. Švec, Peter Popolo

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

To measure the exposure to self-induced tissue vibration in speech, three vocal doses were defined and described: distance dose, which accumulates the distance that tissue particles of the vocal folds travel in an oscillatory trajectory; energy dissipation dose, which accumulates the total amount of heat dissipated over a unit volume of vocal fold tissues; and time dose, which accumulates the total phonation time. These doses were compared to a previously used vocal dose measure, the vocal loading index, which accumulates the number of vibration cycles of the vocal folds. Empirical rules for viscosity and vocal fold deformation were used to …

Characterization Of Mutations And Loss Of Heterozygosity Of P53 And K-Ras2 In Pancreatic Cancer Cell Lines By Immobilized Polymerase Chain Reaction, James Butz, Eric Wickstrom, Jeremy Edwards

Department of Biochemistry and Molecular Biology Faculty Papers

Background

The identification of known mutations in a cell population is important for clinical applications and basic cancer research. In this work an immobilized form of the polymerase chain reaction, referred to as polony technology, was used to detect mutations as well as gene deletions, resulting in loss of heterozygosity (LOH), in cancer cell lines. Specifically, the mutational hotspots in p53, namely codons 175, 245, 248, 249, 273, and 282, and K-ras2, codons 12, 13 and 61, were genotyped in the pancreatic cell line, Panc-1. In addition LOH analysis was also performed for these same two genes in Panc-1 by …

Alternating Metabolic Pathways In Ngf-Deprived Sympathetic Neurons Affect Caspase-Independent Death, Louis K. Chang, Robert E. Schmidt, Eugene M. Johnson Jr.

Open Access Publications

No abstract provided.

Dual Function Of Slit2 In Repulsion And Enhanced Migration Of Trunk, But Not Vagal, Neural Crest Cells, Maria Elena De Bellard, Yi Rao, Marianne Bronner-Fraser

Open Access Publications

No abstract provided.

Medical Education Digest, Vol. 5 No. 4 (July 15, 2003), Nova Southeastern University

Medical Education Digest

No abstract provided.

Obesity In America: A Growing Threat, Eileen Salinsky, Wakina Scott

National Health Policy Forum

This background paper seeks to clarify the nature and causes of the obesity epidemic in the United States and provides an overview of the associated economic and health costs. The paper summarizes existing federal programs and policies that address obesity and examines new and emerging policy strategies to battle the bulging American silhouette. Topics explored include population-based prevention, federal food- and nutrition-assistance programs, Medicare and Medicaid payment policies, school health initiatives, and publicly funded biomedical research.

History Of Depression And Smoking Cessation Outcome: A Meta-Analysis, Brian Hitsman, Belinda Borrelli, Dennis E. Mcchargue, Bonnie Spring

Department of Psychology: Faculty Publications

The authors conducted a meta-analysis of published studies to (a) evaluate the premise that a history of major depression is associated with failure to quit smoking and (b) identify factors that moderate the relationship between history of depression and cessation outcome. Fifteen studies met the selection requirements and were coded for various study methodology and treatment characteristics. DSTAT was used to calculate individual study effect sizes, determine the mean effect size across studies, and test for moderator effects. No differences in either short-term (≤ 3 months) or long-term abstinence rates (≥ 6 months) were observed between smokers positive versus negative …

The Triterpenoid Cddo Inhibits Expression Of Matrix Metalloproteinase-1, Matrix Metalloproteinase-13 And Bcl-3 In Primary Human Chondrocytes, Sarah Elliott, Ezra Hays, Michael Mayor, Michael Sporn, Matthew P. Vincenti

Dartmouth Scholarship

A synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), has been reported to have anti-inflammatory properties and to decrease the interleukin-1 (IL-1)-induced expression of matrix metalloproteinase-1 (MMP-1) and MMP-13. We have shown previously that IL-1 induces expression of the inhibitor of NF-κB (IκB) family member Bcl-3, and that this contributes to MMP-1 expression. To quantify the effects of CDDO on IL-1-induced MMP-1, MMP-13 and Bcl-3 expression, we stimulated the chondrosarcoma cell line SW-1353 and human primary chondrocytes with IL-1, in the presence or absence of CDDO. Harvested RNA was subjected to quantitative real-time reverse-transcriptase polymerase chain reaction. In SW-1353 cells, 300 nM CDDO …