Digital Commons Network^™

One Can Only Dream, Sophia V. Yacca

Theses and Dissertations

One Can Only Dream is an interactive installation in which players are invited to navigate a liminal, dream-like game, engage with a branching series of questions, and introspect upon the relationships between unconscious expression, conscious self-perception, and the inherent difficulty of depicting, sharing, and understanding subconscious thought.

Rooted in both my personal experience with a rare neurophysiological condition and in my desire to create, this project examines dreams not only as a medical and cultural phenomenon, but also as a means to form identity, reflect trauma, and inspire creativity. Drawing from modern interactive storytelling and my lived experiences, this work …

Out From Under: Stories Of Endometriosis, Prisca Edwards

Theses and Dissertations

Six individuals. One diagnosis. In Out From Under, people living with endometriosis gather for an art-centered workshop. Through collage and conversation, they transform isolating medical experiences into paths of connection and collective healing.

Endometriosis affects approximately one in ten women of reproductive age, yet diagnosis is often delayed by nearly a decade. During this time, many suffer from debilitating symptoms without adequate care or accessible treatment. Out From Under explores the lived experience of endometriosis through the lens of socially engaged documentary filmmaking. Participants share their medical histories, emotions, and frustrations in a structured yet open environment designed for intimacy, …

Examining Loss Of Imprint In F1 Hybrid Female Mice Due To X Chromosome Epimutation And The Implications For Autism, Arianna H. Roach

Honors Scholar Theses

Sex biases are prevalent among various neurodevelopmental disorders, with males experiencing them at higher frequencies or severities than females. This male bias is poorly understood, and our lab aims to elucidate this mechanism using our model of transgenerational epigenetic inheritance. Our lab identified the cluster of genes Xlr3b/4b/4c on the X chromosome that are imprinted in the female brain. Preliminary studies suggest that Xlr3 acts as a mediator molecule in our model. Xlr3 knockdown male mice exhibited significant meiocyte loss that can be attributed to Meiotic Sex Chromosome Inactivation. Their female offspring also displayed loss of imprinting of Xlr3 and …

The Interaction Between Physical Activity And Fruit And Vegetable Intake On Body Composition, Om S. Ghetia

Honors Scholar Theses

Objective: Fruit and Vegetable (FV) intake and Physical Activity (PA) are important lifestyle factors associated with body composition. This study assessed the combined impact of meeting FV intake and PA recommendations on body composition measures including body mass index (BMI), percent body fat (PBF), and waist circumference (WC) in adults aged 20–64 years from diverse backgrounds.

Design: A cross-sectional study conducted in Northeastern Connecticut.

Methods: A total of 124 participants completed a one-week dietary and PA record followed by anthropometric assessments. Participants were categorized into groups based on FV intake (≥400 g/day vs. < 400 g/day) and PA levels (≥600 MET-minutes/week vs. < 600 MET-minutes/week). Independent t-tests and chi-square tests were used to compare dietary intake, PA levels, and body composition outcomes across groups.

Results: Participants meeting FV recommendations had significantly …

Editorial–Special Issue On Application Of Cold Atmospheric Plasma In Human And Veterinary Disease, Katharina Stapelmann, Eloisa Sardella, Vandana Miller

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

Plasma medicine is a rapidly evolving interdisciplinary field that combines plasma science and engineering, chemistry, biology, and medicine. This special issue focuses on various ways to apply cold atmospheric pressure plasma in translating plasma technology into clinical applications. Ongoing research on the redox-based mechanism of plasma action, the concept of 'plasma dose' and device control is critical for advancing plasma medicine. As these applications move toward the clinic, ensuring the reproducibility and quality control of plasma sources is essential. The articles in this issue present examples of both direct and indirect plasma applications, with indirect treatments describing cell exposure to …

Know Thyself: A History Of Ancient Neuroscience, Alex Delano

Departmental Honors & Graduate Capstone Projects

Neuroscience is often described as one of the youngest bodies of science, but documented study of the brain begins as early as the Neolithic period. The ancient Mediterranean was a hub for science, mathematics, philosophy, and literature, all disciplines necessary for the study of the brain. Evidence of neurosurgical procedures like trepanation and craniotomy began in the Neolithic period and were practiced and improved upon throughout the ancient Mediterranean. The first detailed studies on brain anatomy were carried out in the 3^rd century BCE in Greece which created a necessary structure for future scientists to build on. While many …

The Impact Of Norepinephrine Exposure On Microglia Il-1b Production, Mikyas Telahun, Meah Katz, Kristy Bagley

Research and Creativity Symposium

Neuroinflammation, driven by proinflammatory cytokines, is linked to Alzheimer’s Disease (AD). Norepinephrine (NE) activates microglial adrenergic receptors, potentially increasing IL-1β production. This study investigates the effects of NE exposure on IL-1β production in human microglial cells, using adrenergic receptor-specific antagonists to isolate the effects of α1-AR, α2-AR, β2-AR, and combined α1& β2 -AR pathways. Microglia were treated with 100nM antagonists and exposed to control (0μM), medium (1 μM) or high (10 μM) NE concentrations. Media was collected at 3, 6 and 9 days, and protein content was standardized using a BioRad Protein Assay. IL-1β levels were quantified via ELISA (Sigma). …

Investigating The Ability Of The Norepinephrine-Dopamine Reuptake Inhibitor Nomifensine To Reverse The Effort-Related Effects Of Tetrabenazine In Female Rats, Vivien Daytree

Honors Scholar Theses

Anergia, lassitude, and psychomotor retardation are core symptoms of motivational dysfunction that often accompany Major Depressive Disorder (MDD). While selective serotonin reuptake inhibitors effectively alleviate mood and anxiety symptoms, they remain relatively ineffective at alleviating motivational deficits. Compounds that elevate extracellular dopamine (DA) have shown promise in addressing these symptoms. Bupropion, a norepinephrine-dopamine reuptake inhibitor (NDRI), increases DA and is effective at attenuating motivational symptoms in patients. Another NDRI, nomifensine, has demonstrated potential antidepressant properties in preclinical research. Effort-based choice tasks, such as the FR5/chow choice task, serve as animal models for studying motivational dysfunction. Rats choose between exerting effort …

Staff Education To Improve Staff Knowledge And Attitudes Regarding Aggressive Patient Behaviors, Roya Khoshbakht

Walden Dissertations and Doctoral Studies

Aggressive behavior among psychiatric patients threatens safety and quality in healthcare, causing physical and psychological harm to staff and contributing to burnout and high turnover rates. This Doctor of Nursing Practice (DNP) project addressed gaps in staff knowledge and attitudes, particularly among nurses, regarding aggression management and de-escalation techniques through a comprehensive education program on the causes of aggression, warning signs, and effective strategies. The evidence-based practice (EBP) question was, Will staff education on evidence-based strategies for preventing and managing aggressive behavior improve staff knowledge and attitude? Project team members used the Johns Hopkins Evidence-Based Practice (JHEBP) model to develop …

Longitudinal Profiling Of Circulating Tumor Dna Reveals The Evolutionary Dynamics Of Metastatic Prostate Cancer During Serial Therapy, Yuehui Zhao, Naveen Ramesh, Ping Xu, Emi Sei, Min Hu, Shanshan Bai, Patricia Troncoso, Ana M Aparicio, Christopher J Logothetis, Paul G Corn, Nicholas E Navin, Amado J Zurita

Faculty, Staff and Student Publications

Treatment decisions in metastatic castration-resistant prostate cancer are mostly guided by clinical variables, but efforts to molecularly monitor the disease remain hampered by challenges in acquiring tumor tissue repeatedly. In this study, we simultaneously profiled the genome copy number and exome in longitudinal plasma circulating tumor DNA (ctDNA) acquired before, during, and upon progression to serial treatments with androgen signaling inhibitors and taxane chemotherapy from 60 patients with metastatic castration-resistant prostate cancer (2-10 samples per patient). The genomic data were used to delineate the clonal substructure and evolutionary dynamics of each patient, and an evolutionary dynamic index was developed to …

Second Language Acquisition For Adults, Sara Santos Costa

Seton Hall University Dissertations and Theses (ETDs)

The process of Second Language Acquisition (SLA) has been explored by several scholars, who start with fundamental questions such as: “Does second language acquisition work in the same way as first language acquisition?” “What are the differences in the processes each individual experiences?” “Is it possible to become fluent in a second language at an older age?” This paper aims to show some key research conducted on this topic and provide a clear understanding of the processes that second language learners face.

This paper will delve into three main approaches to SLA: Behaviorist Theory, Universal Grammar (UG) and Interactionist Theory. …

Genomic Characterization Of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features In Black Individuals, Katherine A Lawson-Michod, Jeffrey R Marks, Lindsay J Collin, David A Nix, Natalie R Davidson, Chad D Huff, Yao Yu, Aaron Atkinson, Courtney E Johnson, Lucas A Salas, Lauren C Peres, Casey S Greene, Joellen M Schildkraut, Jennifer A Doherty

Faculty, Staff and Student Publications

Black individuals experience worse survival after a diagnosis of high-grade serous ovarian carcinoma (HGSC) than White individuals and are underrepresented in ovarian cancer research. To date, the understanding of the molecular and genomic heterogeneity of HGSC is based primarily on the evaluation of tumors from White individuals. In the present study, we performed whole-exome sequencing on HGSC samples from 211 Black patients to identify significantly mutated genes and characterize mutational signatures, assessing their distributions by gene expression subtypes. The occurrence and frequency of somatic mutations and signatures by self-reported race were compared with historic data from The Cancer Genome Atlas …

Optimising Non-Cycloplegic Screening Strategies For Early Detection Of Pre-Myopia And Myopia In Young Children, Síofra Harrington, Michael Moore, James Loughman, Ian Flitcroft, Veronica O'Dwyer

Articles

Purpose: Early detection of myopia is essential to delay its onset and progression. Pre-myopia, defined by an inadequate hyperopic reserve, increases myopia risk in childhood. However, effective screening methods remain limited. This study aimed to develop practical non-cycloplegic screening methods for pre-myopia and myopia in 6- to 7-year-olds to support earlier interventions.

Methods: This cross-sectional study of 621 Irish schoolchildren (mean age: 7.12 ± 0.45 years; 51.8% boys) assessed uncorrected distance visual acuity (UDVA). Cycloplegic spherical equivalent refraction (SER) classified refractive status (myopia: SER ≤ −0.50D; pre-myopia: SER > −0.50 ≤ 0.75D). Pre- and post-cycloplegic SER were measured using the Welch …

Epidemiology, Risk Factors And Clinical Outcome Of Candidaemia: A Decade-Long Experience At A University Hospital In Oman, Tasneem Al Salmani, Asmaa S. Mahdi, Abdullah Balkhair, Turkiya Al Siyabi, Hashim Ba Wazir

Sultan Qaboos University Medical Journal

Objectives: This study aimed to examine a decade-long epidemiology of candidaemia to explore the risk factors associated with it, and describe its clinical outcomes in hospitalised adult patients. Methods: This retrospective observational study was conducted at Sultan Qaboos University Hospital, Muscat, Oman. Adult patients with candidaemia hospitalised between January 2007 and December 2016 were included. The hospital infection control department surveillance registry on bloodstream infections (BSIs) was used to identify Candida BSIs. Patients' electronic medical records were searched for demographic characteristics, clinical risk factors and outcomes. Results: Candida albicans was the most common Candida species among 152 …

Incidence And Predictors Of Permanent Pacemaker Implantation Following Transcatheter Aortic Valve Replacement: Two-Centre Experience From Oman, Mohamed N. Al Rawahi, Adil Al Kindi, Ahmed Al Yarubi, Ahmed Shams, Adil Al Riyami, Hatim Al Lawati, Ahmed El Said, Mohamed Al Riyami, Khalid Al Saidi, Ismail Al Abri, Najib Al Rawahi, Abdullah Al Ismaili, Fahad Al Kindi, Muhammad A. Sadiq, Sunil K. Nadar

Sultan Qaboos University Medical Journal

Objectives: This study aims to evaluate the predictors and rate of permanent pacemaker (PPM) implantation among patients undergoing transcatheter aortic valve replacement (TAVR) at two institutions in Oman. TAVR has become the standard of care for patients with severe aortic stenosis at high risk for surgery. However, it is associated with a high PPM implantation rate. Methods: This was a retrospective study involving all patients undergoing TAVR at two leading cardiac centres in Oman over seven years, from May 2013 to September 2020. We included patients who survived the procedure to discharge and those who were followed-up for …

Mrn-Ctip, Exo1, And Dna2-Wrn/Blm Act Bidirectionally To Process Dna Gaps In Parpi-Treated Cells Without Strand Cleavage, Isabelle M Seppa, Mithila Tennakoon, Jessica Jackson, Celia D Rouault, Sumedha Agashe, Vladislav O Sviderskiy, Mangsi Limbu, Erica Lantelme, Alice Meroni, Priyanka Verma, Alessandro Vindigni, Et Al.

2020-Current year OA Pubs

Single-stranded DNA (ssDNA) gaps impact genome stability and PARP inhibitor (PARPi) sensitivity, especially in BRCA1/2-deficient tumors. Using single-molecule DNA fiber analysis, electron microscopy, and biochemical methods, we found that MRN, CtIP, EXO1, and DNA2-WRN/BLM resect ssDNA gaps through a mechanism different from their actions at DNA ends. MRN resects ssDNA gaps in the 3'-to-5' direction using its pCtIP-stimulated exonuclease activity. Unlike at DNA ends, MRN does not use its endonucleolytic activity to cleave the 5'-terminated strand flanking the gap or the ssDNA. EXO1 and DNA2-WRN/BLM specifically resect the 5' end of the gap independent of MRN-CtIP. This resection process alters …

Artificial Intelligence-Based Virtual Staining Platform For Identifying Tumor-Associated Macrophages From Hematoxylin And Eosin-Stained Images, Arpit Aggarwal, Mayukhmala Jana, Amritpal Singh, Tanmoy Dam, Himanshu Maurya, Tilak Pathak, Sandra Orsulic, Kailin Yang, Deborah Chute, Justin A Bishop, Farhoud Faraji, Wade M Thorstad, Shlomo Koyfman, Scott Steward, Qiuying Shi, Vlad Sandulache, Nabil F Saba, James S Lewis, Germán Corredor, Anant Madabhushi

Faculty, Staff and Students Publications

Background: Virtual staining is an artificial intelligence-based approach that transforms pathology images between stain types, such as hematoxylin and eosin (H&E) to immunohistochemistry (IHC), providing a tissue-preserving and efficient alternative to traditional IHC staining. However, existing methods for translating H&E to virtual IHC often fail to generate images of sufficient quality for accurately delineating cell nuclei and IHC+ regions. To address these limitations, we introduce VISTA, an artificial intelligence-based virtual staining platform designed to translate H&E into virtual IHC.

Methods: We applied VISTA to identify M2-subtype tumor-associated macrophages (M2-TAMs) in H&E images from 968 patients with HPV+ oropharyngeal squamous cell …

Correlation Between Varicella-Zoster Virus Infection And Cancer Development: A Comprehensive Analysis, Fernando Cisneros, Blake Martin, Shizue Mito

School of Medicine Publications

Varicella-zoster virus (VZV) is a highly prevalent pathogen primarily recognized for causing chickenpox during primary infection, and herpes zoster (HZ), also known as shingles, upon reactivation. While post-infectious complications of VZV, such as encephalitis, pneumonia, and post-herpetic neuralgia, are well-established, recent large population-based studies suggest that HZ may increase the risk of occult cancers. This has sparked discussions on the need for cancer screening in patients with HZ to improve early diagnosis and prognosis. However, the specific types of cancers most strongly associated with VZV reactivation have not been systematically identified, and the subsequent cancer risk remains inconclusive. Emerging evidence …

A Tobacco Treatment Training Program Expands The Number Of Healthcare Providers Trained To Use Evidence-Based Practices And Methods, Alex Hurst, Maher Karam-Hage, Jennifer Cofer, Mehwish Javaid, Diane Beneventi, Janice Blalock, Tiffany Winter, Paul M. Cinciripini, Ernest Hawk

Advances in Cancer Education and Quality Improvement

Tobacco-use disorder remains a global health challenge, despite declining rates, and is a leading cause of morbidity and mortality, especially among special populations that disproportionally do not have access to comprehensive treatment services. The lack of trained providers and slow dissemination of new tobacco treatment knowledge are obstacles to accessing comprehensive evidence-based treatments. Less is known about the impact of specialized training programs on healthcare professionals' ability to effectively treat tobacco use. This paper reports on the evaluation of the tobacco treatment training program, training methodology, and the demographics of the specialists trained.

MD Anderson’s Tobacco Treatment Training Program (TTTP) …

Impact Wv: Adapting Patient Navigation Models Of Care To Improve Services To Caregivers Of Infants Exposed To Substances In Utero, Charlotte S. Workman Bsms, Ccrp, Lesley Cottrell, Mawyah Bashatah, Aisha Hashmi, Kayla Richard, Poornima Murthy, Susan Harrison, Ashleigh Mckinsey, Amy Bott, Sydney Leary, Cody Smith, Melina Danko

Journal of Appalachian Health

Patient navigation (PN) is a healthcare service delivery model designed to partner clients with service providers to reduce challenges to health care, as well as to improve access to care by identifying opportunities to coordinate services for clients. The IMPACT WV project at the West Virginia University Center for Excellence in Disabilities (WVU CED) implemented PN models of care for caregivers of infants exposed to substances in utero. The purpose of this program was to reduce burden for potentially at-risk families and improve caregiver and infant outcomes as a result. To understand the processes that influence the implementation of PN …

Determinants Of Willingness To Share Wearable Health Data With Health Care Providers In Appalachian Populations: An Exploratory Study, Gilbert Munoz Cornejo, Joonghee Lee

Journal of Appalachian Health

Background: Wearable health devices capture metrics (e.g., physical activity, ECG, sleep) that can enhance care when shared with providers. Yet, willingness to share wearable data may differ in Appalachia, where chronic disease burdens, mistrust, and limited infrastructure pose unique challenges.

Objective: This study explored (1) which sociodemographic, health, and digital behaviors correlate with willingness to share wearable data and (2) how these insights can guide region-specific interventions in Appalachia.

Methods: We analyzed 320 Appalachian respondents from the Health Information National Trends Survey (HINTS 6). Descriptive statistics and logistic regression models examined willingness to share wearable data. Because of small cell …

Table Of Contents And Front Matter, Bjur Staff

Butler Journal of Undergraduate Research

No abstract provided.

Excess Fructose In High-Fructose Corn Syrup Reduces Cell Viability & Promotes Nitric Oxide Release In Raw 264.7 Macrophages, Renzo F. Galarza, Edward L. Villegas

Research and Creativity Symposium

High-fructose corn syrup (HFCS) is an artificial sweetener that contains slightly higher concentrations of fructose compared to standard sucrose. It has been linked to an increased risk of obesity, type 2 diabetes, cardiovascular disease, and fatty liver disease. While both HFCS and sucrose are widely used sweeteners, growing evidence suggests they may differ in their inflammatory potential. We sought to understand the effects of elevated fructose on RAW 264.7 macrophages. To investigate these effects, we treated the cells with either a sucrose solution or a
solution designed to mimic high-fructose corn syrup. Lipopolysaccharide (LPS) stimulation was used to model innate …

Weed Out The Pain: Using Cannabis To Manage Endometriosis, Jamie Calderbank, Holly Goodacre, Claire Mcelroy, Makayla Schmierer

NURS 464: Evidence-Based Nursing Capstone

Those with endometriosis are four times more likely to chronically use opioids than those without the condition, despite the well-known adverse effects and misuse potential of opioids (Farooqi et al., 2023). Due to the risks and costs associated with opioid use, those with endometriosis are turning to other forms of self-medication that are more accessible. One example is the use of cannabis, which has been shown to not only decrease pain but also improve other symptoms like sleep quality and overall mood (Sinclair et al., 2021). Endocannabinoids are a series of complex molecules that naturally exist in the body and …

Pain Management During Intrauterine Device Insertion: A Research Synthesis, Nicole D. Haradisty, Flora V. Maciel Garibay, Dylan D. Renfro

NURS 464: Evidence-Based Nursing Capstone

The mismatch between expected and actual pain during IUD insertion can negatively impact patients' healthcare experience, satisfaction, and trust in their medical providers (Bayer et al., 2025). Inadequate pain management during IUD insertion serves as a significant barrier for individuals of reproductive age seeking this form of contraception (Bayer et al., 2025). It is essential to address the lack of universal pain management protocols during IUD insertions. Equally important is identifying effective options to manage pain while ensuring that providers set and manage patient expectations appropriately. This study aims to explore the pain experienced during IUD insertion and to identify …

Impact Of Microplastics On Male Fertility And Sperm Quality, Maura Blackwell, Yelena Gallagher-Spiegle, Regina Ochoa, Abbi Wong

NURS 464: Evidence-Based Nursing Capstone

Plastic pollution is a global health concern. Microplastics and nanoplastics are the byproducts of plastic deterioration and can be invisible to the naked eye. These ever-present particles have infiltrated our ecosystems, water, food, air, and even the human body (Hunt et al., 2024). In recent years, we are starting to understand the effects of plastic degradation on human health. Researchers have observed ultraviolet radiation, high temperatures, and other physical deterioration causing microplastics to shed carcinogenic and endocrine disrupting chemicals (Osman et al., 2023). Endocrine disruptors such as bisphenol A (BPA), nonylphenol, and octylphenol, interfere with normal hormone activity, mimicking natural …

Doctor Of Physical Therapy Student Performance On The National Physical Therapy Examination And Qualitative Feedback Of Dpt Program Administrators About The Covid-19 Pandemic In The Appalachian Region, Timothy Logan Yost

Ed.D. Dissertations

In this qualitative case study, I aimed to discern the presence of a downward trend in the National Physical Therapy Examination (NPTE) during the COVID-19 pandemic and receive valuable qualitative feedback from Doctor of Physical Therapy program administrators concerning the effects of COVID-19. I first reviewed the available literature, followed by an examination of first-time scores via publicly available data from the Federation of State Board of Physical Therapy (FSBPT). This was followed by the development of a qualitative research methodology, which included a targeted qualitative questionnaire with Doctor of Physical Therapy program administrators within the Appalachian region to gain …

A Joint Endeavor: Methotrexate Vs. Jak Inhibitors For Joint Inflammation Reduction In Rheumatoid Arthritis, Madeleine Kennedy

Physician Assistant Scholarly Project Posters

This paper investigates the comparative efficacy of Janus kinase (JAK) inhibitors versus methotrexate (MTX) in reducing joint inflammation in adult patients with rheumatoid arthritis (RA). The study addresses the critical research question: In adult patients with RA, does treatment with JAK inhibitors or methotrexate demonstrate superior efficacy in reducing joint inflammation? A literature review was conducted analyzing various clinical trials, including phase II and III studies, that evaluated the effectiveness of JAK inhibitors, both as monotherapy and in combination with MTX. The findings indicate that JAK inhibitors, particularly tofacitinib and baricitinib, consistently show superior or equivalent efficacy in achieving American …

The Promise Of Psilocybin-Assisted Therapy For Opioid Use Disorder, Craig Kimble, Alberto Coustasse

Management Faculty Research

The opioid epidemic presents a profound and escalating public health and economic crisis in the United States. According to the CDC, the economic burden of opioid use disorder and fatal opioid overdose in the U.S. reached an estimated $1.02 trillion in 2017 alone, encompassing healthcare costs, lost productivity, criminal justice expenditures, and premature mortality. While current pharmacologic treatments—such as methadone, buprenorphine, and naltrexone—have proven efficacy, they are not without limitations, including high relapse rates, issues with compliance, stigma, and insufficient engagement in long-term recovery. These shortcomings necessitate an exploration of innovative, cost-effective interventions. One such promising alternative is psilocybin-assisted therapy. …

Exploration Of Advanced Practice Registered Nurses’ Perception Of Barriers To Promoting And Supporting Breastfeeding In Primary Care, Devon L. Stubblefield, Allison L. Scott, Carmel Kruse, Marilou D. Shreve, Hope A. Ballentine

The Eleanor Mann School of Nursing DNP Capstone Projects

Background: Breastfeeding is the biological way to provide active and passive immunity, as well as necessary nutrients, to infants while concurrently providing multiple health benefits for mothers. Even though evidence is readily available to support the argument to breastfeed, United States’ breastfeeding rates fall below Healthy People 2030 goals. Advanced practice registered nurses (APRNs) in primary care settings are in a prime position to give education and create care plans to support breastfeeding mothers to improve breastfeeding rates but literature supports APRNs lack confidence to do so. An APRN is likely to defer care to another provider to address …