Digital Commons Network^™

Human Pain Neuroscience And The Next Generation Of Pain Therapeutics, Bryan A Copits, Michele Curatolo, Patrick M Dougherty, Robert W Gereau, Wenqin Luo, Maryann Martone, Hakan Olausson, Theodore J Price, William Renthal, Clifford J Woolf, Guoyan Zhao

Faculty, Staff and Student Publications

The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies primarily in human-based systems. To realize this transformative potential, further research into somatosensation and pain neuroimmunology in human systems is essential.

Nifuroxazide And 4-Hydroxybenzhydrazone Derivatives As New Antiparasitic (Trypanosoma Cruzi And Leishmania Mexicana) And Anti-Mycobacterium Tuberculosis Agents, Timoteo Delgado-Maldonado, Diana V. Navarrete-Carriola, Lenci K. Vazquez-Jimenez, Alma D. Paz-Gonzalez, Baojie Wan, Scott Franzblau, Othman Mueen Mohammed, Lorena Rodríguez-Páez, Charmina Aguirre-Alvarado, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences Faculty Publications

Background/Objectives: Nifuroxazide (Nfz) is a drug that has been used as a scaffold for designing antimicrobial and antiparasitic agents. This study aimed to synthesize and evaluate in vitro of Nfz and twenty-five 4-hydroxybenzhydrazone derivatives as potential anti-Trypanosoma cruzi, anti-Leishmania mexicana, and anti-Mycobacterium tuberculosis agents.

Methods: The compounds were synthesized by condensing 4-hydroxybenzhydrazide with appropriate aldehydes in acidic conditions and structurally confirmed by spectroscopic techniques. All compounds were evaluated in vitro against T. cruzi strains (NINOA and A1), L. mexicana (M379 and FCQEPS strains), and M. tuberculosis (H37Rv strain), followed by enzymatic assays against T. cruzi …

A Honduran Prevalence Study On Soil-Transmitted Helminths Highlights Serological Antibodies To Tm-Wap49 As A Diagnostic Marker For Exposure To Human Trichuriasis, Neima Briggs, Leroy Versteeg, Rojelio Mejia, Jeroen Pollet, Maria Jose Villar, Bin Zhan, Graeme Segal, Stephanie Novak, Patricia Lenihan, Paul Musgrave, Viviana Ellis, Carol Florencia Coello, K Jagannadha Sastry, Joe Craft, Peter J Hotez, Maria Elena Bottazzi

Faculty, Staff and Student Publications

Soil-transmitted helminth (STH) infections rank among the most prevalent communicable diseases of humans, yet detection of these parasites is mostly restricted to identifying active infection through fecal examinations. Currently, there are no commercial diagnostic tools to identify a prior whipworm or hookworm exposure, and the few serological assays for roundworm infection have not been well validated for crossreactivity or infections in humans. Such diagnostic restrictions limit the range of scientific and clinical questions that surround STH exposures and their implicated relationship to chronic diseases, such as autoimmunity, allergy, and cancer. The goal of this investigation was to evaluate the diagnostic …

Towards The Performance Characterization Of A Robotic Multimodal Diagnostic Imaging System, George Papaioannou, Christos Mitrogiannis, Mark Schweitzer, Nikolaos Michailidis, Maria Pappa, Pegah Khosravi, Apostolos Karantanas, Sean Starling, Christian Ruberg

Publications and Research

Characterizing imaging performance requires a multidisciplinary approach that evaluates various interconnected parameters, including dosage optimization and dynamic accuracy. Radiation dose and dynamic accuracy are challenged by patient motion that results in poor image quality. These challenges are more prevalent in the brain/cardiac pediatric patient imaging, as they relate to excess radiation dose that may be associated with various complications. Scanning vulnerable pediatric patients ought to eliminate anesthesia due to critical risks associated in some cases with intracranial hemorrhages, brain strokes, and congenital heart disease. Some pediatric imaging, however, requires prolonged scanning under anesthesia. It can often be a laborious, suboptimal …

Breaking The Stereotype: Small Cell Lung Cancer In A Never-Smoking Patient, Alexandra She, Edward Hamilton, Francis Jenney

Research Day

In the United States, lung cancer is the second most common type of cancer whilst also accounting for 1 in 5 cancer deaths, making it also the deadliest. The vast majority of lung cancer is non-small cell lung cancer (NSCLC), contributing to 87% of all cases, while small cell lung cancer (SCLC) makes up about 13% of all lung cancers1. While SCLC is strongly related to smoking history, here we present a 65-year-old African-American male without a history of smoking tobacco presenting with a rapid progression of unilateral thoracic pain, dyspnea, and unintentional weight loss. The diagnostic work-up included concomitant …

Identifying The Potential Effect Of Zolmitriptan On The 1b Pathway Of Golgi Tendon Organs In Regulating Intermuscular Inhibition In The Extremities To Find A Link In The Mechanism Of Spasticity, Adam E. Davis, T. Richard Nichols

Research Day

The deep dorsal horn (DDH) of the spinal cord is a major integration center for receiving a variety of neural projections from the brainstem as well as a variety of afferent inputs from muscle spindles and Golgi tendon organs (GTOs) in the muscles. Following spinal cord injury (SCI) to the DDH, an overall loss of serotonergic input from the brainstem is observed, for which there is evidence to suggest that this may play a role in inhibiting the activity of bursting interneurons in the DDH, possibly leading to uncontrolled motoneuron activity, hyperreflexia. GTOs primarily supply the force feedback network (FBB), …

Social Determinants Of Health In Patients With Diabetes Mellitus Ii, Iman N. Ashraf, Donald Penney

Research Day

Introduction: More than 37 million people in the United States have diabetes, the majority 90-95% with type 2 diabetes. The social determinants of health (SDH) are the non-medical factors that influence health outcomes. They are the conditions in which people are born, grow, work, live, and age, and the wider set of forces and systems shaping the conditions of daily life. These forces and systems include economic policies and systems, development agendas, social norms, social policies and political systems. The SDH have an important influence on health inequities - the unfair and avoidable differences in health status seen within and …

Skin Graft Treatment For Necrotizing Fasciitis, London Samone Wheeler, Isabella Baeumler, Alramahi Bashar

Research Day

A 40-year-old male presented to the emergency room with perianal pain and left leg pain. During a comprehensive physical exam, a bullous lesion on the left thigh was noted. Further investigation revealed an extensive necrotizing fasciitis infection, confirmed by a pelvic CT scan. This case emphasizes the importance of considering alternative diagnoses in patients with preexisting conditions and highlights the necessity of a thorough diagnostic workup. Additionally, it showcases the effectiveness of skin grafts following extensive surgical debridement in managing such severe infections.

Lead Contamination Propagation Into Plants Of A Metro Atlanta Home, Jaci Carithers, Samantha Gowen, Francis Jenney

Research Day

INTRODUCTION: Lead pollution in residential areas of Metro Atlanta has spurred the EPA to increase efforts to remediate contaminated soil, resulting in the designation of the Westside Lead Atlanta, GA Superfund site. Lead poses significant risks to human health, interfering with vital biological functions, such as blocking important calcium-dependent pathways. Historic practices of lead-based industries with poor disposal procedures have caused local soil and water pollution. This is evident particularly along historical railroad routes used for transporting metal-laden industrial goods. The soil along these routes frequently exhibits heightened levels of heavy metals due to regular train activity, exacerbated by waste …

Health Complications Of Antibacterial-Based Mouthwash On Oral Microbiota: Literature Review, Bhavik Singh, Zoë Rushetsky, Rehana Lakhani, Shifa Gandhi, Francis Jenney

Research Day

Introduction

The human microbiota, including bacteria, fungi, archaea, and viruses, is a diverse and dynamic community of microorganisms that maintains both systemic and oral health. This population regulates immune response, prevents pathogen colonization, and facilitates metabolic processes such as nitrate reduction. Oral microbiota are distinct from gut microbiota but are interconnected through microbial translocation and inflammatory signaling, disruption of this balance is linked to various diseases, including cardiovascular conditions. Emerging evidence suggests that antibacterial mouthwash use may reduce nitrate-reducing bacteria, impairing nitric oxide (NO) production, a key molecule in vasodilation and blood pressure regulation. Understanding this relationship is crucial in …

A 22-Year Journey Of Scalp Lupus: The Price Of Delayed Care In Chronic Cutaneous Lupus Erythematosus, Rami B. S. Mansour, Joseph M. Dyer

Research Day

Background:

Discoid lupus erythematosus (DLE) is a relentless autoimmune disease that, when affecting the scalp, can lead to permanent, disfiguring scarring alopecia. Despite its potential for early intervention, many cases go undiagnosed or undertreated, leaving patients with irreversible damage. This case follows a 22-year trajectory of progressive scalp DLE, illustrating the consequences of delayed care and the challenge of managing chronic cutaneous lupus.

Case Presentation:

A 67-year-old woman presented with severe scalp itching, persistent hair loss, and scarring. She was first diagnosed with scalp DLE 22 years ago after months of unresponsive treatment. A biopsy at the time confirmed characteristic …

Predisposing Factors, Outcomes, And Treatment Approach To Fluid Gusher Complication During Cochlear Implant Surgery, Nolan P. Gillihan, William C. Jones, Matthew J. Alexander, Bhavik Singh, Ahmad B. Cader

Research Day

Our research focused on the fluid gusher complication from cochlear implant surgery. Fluid gusher is one of the most prevalent complications of cochlear implant surgery and occurs when cerebral spinal fluid leaks from the cochleostomy site. The complication occurs with opening the round window. We performed a systematic review of the literature, focusing on overviews of cochlear implant surgery complications. There are many factors contributing to the cause of fluid gushers including, biological sex, age, time of procedure, follow up time, temporal bone abnormalities, and abnormalities of the lateral wall of the internal auditory canal. Fluid gusher puts some patients …

Liposomal Formulation To Treat Skin Infections Caused By Staphylococcus Aureus, Tiffanie Hoang, Sameer Joshi

Research Day

Introduction: Skin is the largest organ of the human body and is a strong barrier against various infections, including bacterial infections. According to the American Academy of Dermatology (AAD), over 83 million (1-in-4) individuals visit a dermatologist annually in the United States alone. However, the infection gets established and spreads depending on the individual's immunity and skin conditions. Although several drug options are available for treating skin infections staphylococcus aureus, there are still several drugs that can potentially inhibit this bacterial infection but have yet to be used for several reasons, such as toxicity, solubility, etc. Liposomes can deliver …

Preliminary Study: Minimizing The Gap Between Pre-And Post-Spaceflight, Caleb E. Scheideger, Louis A. Diberardino

Aurora

Long-duration space missions pose significant challenges to astronaut health, primarily due to the detrimental effects of microgravity on musculoskeletal and cardiovascular systems. This research proposal aims to address the critical gap between pre- and post-spaceflight physiological conditions, focusing on the marked decline in muscle mass, bone density, and cardiovascular function. Existing countermeasures, such as resistive exercise, are insufficient to prevent muscle atrophy and bone demineralization, highlighting the need for novel solutions. Neuromuscular Electrical Stimulation (NMES) emerges as a promising intervention, capable of eliciting muscle contractions to maintain function and mitigate atrophy. By integrating NMES into existing exercise regimens, we hypothesize …

Using A Pharmacokinetic Model To Design And Evaluate An Early Ctdna Biomarker For Response To Targeted Therapy, Aaron Li

Spora: A Journal of Biomathematics

Early prediction of response to therapy or lack thereof can help physicians plan treatment more efficiently. Biomarkers based on circulating tumor DNA (ctDNA) are promising. However, biomarkers beyond direct comparison to baseline have not been thoroughly explored. We develop a model for ctDNA shedding under targeted therapy that incorporates pharmacokinetics. Using a simulated cohort of virtual patients with varied parameters, we define and analyze a biomarker based on ctDNA samples at baseline, 12 hours, and 24 hours after initiation of treatment. The biomarker identified patients who would achieve partial or complete response with high sensitivity and specificity and was able …

Physical Function In Young And Older Adult Active Pickleball Players – A Cross-Sectional Study, Leighanne T. Paulson, Eric Martin, Kent Adams, Marcus M. Lawrence

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 5, 2025. Limited information exists on pickleball’s impact on physical function in older adults (65+ years), despite reported health benefits. PURPOSE: This cross-sectional study evaluated the physical function of active older adult (OA) women and men recreational pickleball players via handgrip strength (HGS) and fatigue (HGF), 6-minute walk distance (6MWD) test, as well as the short physical performance battery (SPPB) compared to sex-matched young adult (YA) controls. METHODS: Thirty YA (18-26 years; n=15 women/men) and 27 OA (65-89 years; n=13 women, n=15 men) participants who played pickleball …

Lawyers, Trauma, And Professional Well-Being: How The Legal Community Takes Back Its Mental Health, Brenda D. Gibson

Arkansas Law Review

Accompanying a notable shift in the legal academy to being more attentive to our students’ mental health, there must be an equal (or even greater) shift to focusing on trauma, mental health, and well-being in the broader profession. Significantly, trauma and its effects are compounded when combined with the challenges faced by underrepresented populations within the profession. To date, these challenges have been greeted by an ad hoc, piecemeal reaction to stress and trauma,10 which only inhibits wellness in the profession. Part I explores the current literature in both the humanities and the legal profession, beginning with a brief discussion …

Getting An “A” In Category A Waste, Christa Arguinchona

Conferences

No abstract provided.

Region 10 Special Pathogen Transport Preparedness, Providence - Special Pathogens Program

Conferences

No abstract provided.

Sculpting Healing Spaces: Bridging The Gaps In Cancer Care Facilities, Mayra B. Mendez

Bachelor of Architecture Theses - 5th Year

Healthcare environments become a vital component in patient outcomes, particularly in Cancer Care Facilities, where the emotional and physical requirements of treatment are profound. Exploring how the reconsideration of cancer care facilities can reshape the patient’s experience and improve the healing outcomes. Traditional clinical spaces, often sterile and impersonal, can increase patient stress, anxiety, and discomfort. Cancer care facilities in the Atlanta region are struggling to meet the demands of modern cancer treatment due to architectural limitations such as overcrowded spaces, inefficient layouts, and a lack of patient-centered environments. How can the integration and experience of Biophilic Design Principles bridge …

Implementation Of An Evidence-Based Hearing Education Project For Patients And Their Care Partners, Jennifer Mahoney

Doctoral Projects

Hearing loss is a significant communication issue that impacts relationships, safety, and mental and physical health. There is an increased risk of dementia as well as increased mortality associated with untreated hearing loss. Hearing aids are one of the main treatments for hearing loss, but they are frequently not used. Cognitive impairment, osteoarthritis of the hands, cost and complexity are some of the reasons that hearing aids do not get utilized. But research has shown that involving family members and care partners in trainings on how to use hearing aids may increase use of them. The goal of this project …

When Zebras Attack: Special Pathogens Preparedness In An Ever-Changing World, Jonathan Grien

Conferences

No abstract provided.

Multilevel Factors Influencing Perceived Barriers To Adjuvant Endocrine Therapy Among Breast Cancer Patients At Medication Onset, Timothy Cocozza, Rita Smith, Ana Maria Lopez, Shari Rudoler, Rachel Slamon, Tingting Zhan, Jazmarie L. Vega, Minal Dhamankar, Aruna Padmanabhan, Suzanne M. Miller, Kuang-Yi Wen

Department of Medical Oncology Faculty Papers

Purpose: Adjuvant endocrine therapy (AET) significantly diminishes recurrence and mortality risks in hormone receptor-positive breast cancer (BCa) patients. Nonetheless, suboptimal adherence and premature discontinuation during the initial year of treatment undermine these positive outcomes. This study aims to understand the potential diverse factors associated with perceived barriers to AET compliance at the onset of medication. Methods: We assessed perceived barriers to AET using the ASK-20 instrument for BCa patients initiating AET within 3 months. Our survey also included demographic variables (e.g., musculoskeletal symptoms) and clinical traits (e.g., medication type). Stepwise regression analyses were employed to elucidate the links between multilevel …

Spectrum Of Coronary Artery Involvement With Multisystem Inflammatory Syndrome In Children Versus Kawasaki Disease., Simon Lee, Ashraf S. Harahsheh, Geetha Raghuveer, Michael A. Portman, Arash A. Sabati, Michael Khoury, Nagib Dahdah, Marianna Fabi, Supriya S. Jain, Audrey Dionne, Kyle Runeckles, Frederic Dallaire, Nadine F. Choueiter, Tyler H. Harris, Matthew D. Elias, Anji T. Yetman, Balasubramanian Sundaram, Luis M. Garrido-Garcia, Nilanjana Misra, Cedric Manlhiot, Pedrom Farid, Brian W. Mccrindle

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: There is significant overlap in clinical features between multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD). We sought to compare the prevalence, severity, and associated factors for coronary artery (CA) involvement.

METHODS AND RESULTS: From January 1, 2020 through January 31, 2023, 1191 patients with MIS-C and 554 patients contemporaneously diagnosed with KD were enrolled into the International Kawasaki Disease Registry. Demographic and clinical features, laboratory values, maximum Z score in any CA branch +2.5 or greater) were determined separately for each diagnosis using multivariable logistic regression analyses. The prevalence of CA aneurysms was lower for MIS-C …

Progressive Multifocal Leukoencephalopathy In Chimeric Antigen Receptor T-Cell Therapy Recipients: A Case Study, Michelly Abreu, Chirag B Patel, Krina Patel, Fareed Khawaja, Sudhakar Tummala

Faculty, Staff and Student Publications

Chimeric antigen receptor (CAR) T-cell therapy is a novel immunotherapy modality that has shown remarkable response rates in refractory hematologic malignancies, including multiple myeloma (MM). Cytokine release syndrome (CRS) and neurotoxicity are well-described side effects of this therapy. CAR T-cell therapy recipients are also at increased risk for infections due to immune dysfunction, history of multiple lines of therapy, history of lymphodepleting chemotherapy prior to cell infusion, and prolonged B-cell aplasia. Progressive multifocal leukoencephalopathy (PML) is an opportunistic disease of the central nervous system caused by the reactivation of JC virus (JCV) in the setting of immunosuppression, which leads to …

Reduced Vns Settings Paradoxically Decreases Seizure Burden In A Patient Following Resolution Of Sleep Disordered Breathing, Austin Sponaugle, Rebecca Stainman, Christopher M. Carosella

Abington Jefferson Health Papers

Vagus nerve stimulation (VNS) can be a highly effective treatment option for patients with drug resistant epilepsy. Notably, VNS has demonstrated side effects including a unique form of sleep disordered breathing known as vagus nerve stimulator associated sleep disordered breathing (VaS). However, the ways in which VaS interacts with seizure frequency is unknown. We report a case of a 28-year-old woman who presented to our department with complaints of worsening sleep quality 3 years following VNS implantation. Upon polysomnographic (PSG) evaluation, it was discovered that she suffered from VaS. The patient’s VNS output current was then down titrated during a …

Lifespan Reference Curves For Harmonizing Multi-Site Regional Brain White Matter Metrics From Diffusion Mri, Alyssa H Zhu, Talia M Nir, Shayan Javid, Julio E Villalón-Reina, Amanda L Rodrigue, Lachlan T Strike, Greig I De Zubicaray, Katie L Mcmahon, Margaret J Wright, Sarah E Medland, John Blangero, David C Glahn, Peter Kochunov, Douglas E Williamson, Asta K Håberg, Paul M Thompson, Neda Jahanshad

Faculty, Staff and Student Publications

Age-related white matter (WM) microstructure maturation and decline occur throughout the human lifespan, complementing the process of gray matter development and degeneration. Here, we create normative lifespan reference curves for global and regional WM microstructure by harmonizing diffusion MRI (dMRI)-derived data from ten public datasets (N = 40,898 subjects; age: 3-95 years; 47.6% male). We tested three harmonization methods on regional diffusion tensor imaging (DTI) based fractional anisotropy (FA), a metric of WM microstructure, extracted using the ENIGMA-DTI pipeline. ComBat-GAM harmonization provided multi-study trajectories most consistent with known WM maturation peaks. Lifespan FA reference curves were validated with test-retest data …

Axl Promotes Inflammatory Breast Cancer Progression By Regulating Immunosuppressive Macrophage Polarization, Lan T H Phi, Yating Cheng, Yohei Funakoshi, Francois Bertucci, Pascal Finetti, Steven J Van Laere, Fang Zou, James P Long, Suguru Ogata, Savitri Krishnamurthy, James M Reuben, Jason M Foulks, Steven L Warner, Jennifer M Rosenbluth, Anil K Sood, Debu Tripathy, Naoto T Ueno, Xiaoping Wang

Faculty, Staff and Student Publications

Background: Tumor-associated macrophages (TAMs) are key promoters of inflammatory breast cancer (IBC), the most aggressive form of breast cancer. The receptor tyrosine kinase AXL is highly expressed in various cancer types, including IBC, but its role in TAMs remains unexplored.

Methods: We examined the effects of AXL inhibitor TP-0903 on tumor growth and tumor microenvironment (TME) component M2 macrophages (CD206+) in IBC and triple-negative breast cancer mouse models using flow cytometry and immunohistochemical staining. Additionally, we knocked out AXL expression in human THP-1 monocytes and evaluated the effect of AXL signaling on immunosuppressive M2 macrophage polarization and IBC cell growth …

Blood Architecture : Designing A Hemophilia Treatment Center Through Biomimetic Principles, Melissa Da Costa Schmidt

Bachelor of Architecture Theses - 5th Year

This thesis explores how biomimetic principles drawn from the blood clotting process can inform the architectural design of hemophilia treatment centers, enhancing their efficiency, adaptability, and patient-centered care. By paralleling the phases of hemostasis—platelet aggregation, clotting factor activation, and fibrin stabilization—with spatial functions, the design proposes a layout where acute care areas are centrally positioned for rapid response, while rehabilitation zones support long-term healing, mirroring the reinforcement phase of clotting. Regulated movement and spatial zoning echo the precise control of clot formation, promoting accessibility, privacy, and reduced congestion. Architectural forms inspired by vascular networks, combined with the use of natural …

Anti-Csf-1r Therapy With Combined Immuno- Chemotherapy Coordinate An Adaptive Immune Response To Eliminate Macrophage Enriched Triple Negative Breast Cancers, Diego A Pedroza, Xueying Yuan, Fengshuo Liu, Hilda L Chan, Christina Zhang, William Bowie, Alex J Smith, Sebastian J Calderon, Nadia Lieu, Weiguo Wu, Paul Porter, Poonam Sarkar, Na Zhao, Constanze V Oehler, Ondrej Peller, M Waleed Gaber, Qian Zhu, Charles M Perou, Xiang H-F Zhang, Jeffrey M Rosen

Faculty, Staff and Students Publications

Patients diagnosed with metastatic triple negative breast cancer (mTNBC) have limited treatment options, are more prone to develop resistance and are associated with high mortality. A cold tumor immune microenvironment (TIME) characterized by low T cells and high tumor associated macrophages (TAMs) in mTNBC is associated with the failure of standard-of-care chemotherapy and immune checkpoint blockade (ICB) treatment. We demonstrate that the combination of immunomodulatory metronomic Cyclophosphamide (CTX) coupled with anti-CSF-1R antibody targeted therapy (SNDX-ms6352) and anti-PD-1 (ICB), was highly effective against aggressive metastatic syngeneic