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Articles 8071 - 8100 of 96684
Full-Text Articles in Entire DC Network
Leading The School Team: A Professional Development Training On Eating Disorders For School Nurses, Michelle Samaniego Concepcion
Leading The School Team: A Professional Development Training On Eating Disorders For School Nurses, Michelle Samaniego Concepcion
Doctor of Nursing Practice (DNP) Projects
Abstract
Background: The COVID-19 pandemic sharply increased the prevalence of eating disorders (EDs) among youth. These conditions are associated with high treatment costs and have the second-highest mortality rate among mental illnesses, surpassed only by opioid overdose, making them a critical concern for school communities.
Local Problem: A learning needs assessment conducted by the Alameda County School Nurses Network identified gaps in school nurses’ knowledge and confidence regarding ED identification, referral, and care coordination. Methods: In response, a Doctor of Nursing Practice (DNP) student scholar developed and implemented an evidence-based, virtual professional development training focused on EDs. The module was …
Impact Of Safety Practices On Laboratory-Acquired Infections In Clinical Laboratories From 2018 To 2023, Lori Bane
Walden Dissertations and Doctoral Studies
Laboratorians identifying unknown pandemic pathogens face elevated risks of laboratory-acquired infections yet limited research examines how regulated safety practices influence these risks. This quantitative, correlational study used the Centers for Disease Control and Prevention’s secondary data (2018–2023) to examine two research questions. The first one questioned whether there were differences in safety incidents between registered and exempt clinical laboratories. The second research question investigated whether there was an association of laboratory incidents between BSL-2 and BSL-3 laboratories. The research was limited to incident reports from registered and exempted clinical laboratories working in BSL-2 and BSL-3 conditions. Guided by the Health …
Finite Element Analysis Of Stress Distribution In Unilateral Distal Extension Partial Dentures: A Comparison Of Four Attachment Designs, Maha Nagy Kamal, Haitham Amr, Abdallah Shokry
Finite Element Analysis Of Stress Distribution In Unilateral Distal Extension Partial Dentures: A Comparison Of Four Attachment Designs, Maha Nagy Kamal, Haitham Amr, Abdallah Shokry
Dentistry
No abstract provided.
Hypersensitivity Assessment Of Non-Carious Cervical Lesions After Treatment With Different Desensitizing Protocols: A Randomized Clinical Trial, Mohamed Fouad Haridy, Hoda Omar Fouda, Mohamed Tarek Heiba, Ahmed Fawzy Aboelezz, Amr Faisal
Hypersensitivity Assessment Of Non-Carious Cervical Lesions After Treatment With Different Desensitizing Protocols: A Randomized Clinical Trial, Mohamed Fouad Haridy, Hoda Omar Fouda, Mohamed Tarek Heiba, Ahmed Fawzy Aboelezz, Amr Faisal
Dentistry
No abstract provided.
Implementation Of Standardized Mobilization Assessment Tools To Promote Patient Ambulation At Medical Surgical Units, Yunxuan Su
Master's Projects and Capstones
The objective is the cardiac medical surgical unit in a hospital in San Francisco not meeting the ambulation goal. This study aims to provide a context for enhancing patients' ambulation levels by using standardized assessment tools Prior Level of Functional (PLOF) and Current Level of Functional (CLOF) in daily practice, thereby strengthening care plans and shortening hospital stay. The methods are microsystem evaluation, SWOT analysis, causal analysis, cost-benefit analysis, Gantt chart, pre & post survey, and flyer education for staff to guide the project implementation. The results are that after the intervention, the compliance of PLOF and CLOF documentation and …
Sickle Cell Mice Exhibit Elevated Plasma Bilirubin And Altered Intracranial Cerebral Blood Velocities That Are Exacerbated By Hypoxia-Reoxygenation, Francisco J. Nunez, Ashraf M. Mohieldin, Amy Y. Pan, Sean P. Palecek, Rahima Zennadi, Ramani Ramchandran, Kevin R. Rarick, Surya M. Nauli
Sickle Cell Mice Exhibit Elevated Plasma Bilirubin And Altered Intracranial Cerebral Blood Velocities That Are Exacerbated By Hypoxia-Reoxygenation, Francisco J. Nunez, Ashraf M. Mohieldin, Amy Y. Pan, Sean P. Palecek, Rahima Zennadi, Ramani Ramchandran, Kevin R. Rarick, Surya M. Nauli
Pharmacy Faculty Articles and Research
Sickle cell disease (SCD) is a genetic disorder characterized by sickle red blood cells (RBCs). Sickle RBCs cause cerebral vasculopathies including vaso-occlusive events, leading to ischemia-reperfusion injury and hypoxic tissue environment. To date, the physiological blood flow velocities in cerebral vessels of preclinical SCD models has not been evaluated under hypoxic-reoxygenation. In our study, we used transcranial ultrasound techniques to measure abnormal blood flow velocities in the internal carotid (ICA) and middle cerebral arteries (MCA) of transgenic sickle cell mice (SS) challenged with hypoxia-reoxygenation. Our study showed that SS mice that underwent hypoxic stress exhibited lower relative mean velocities in …
Unlv Admissions: Effect Of The In-Person Interview On The Holistic Admissions Of Minority Applicants Into The University Of Nevada, Las Vegas Doctor Of Physical Therapy Program, Jonathan Madamba, Walker Riley, Isaiah Taylor
Unlv Admissions: Effect Of The In-Person Interview On The Holistic Admissions Of Minority Applicants Into The University Of Nevada, Las Vegas Doctor Of Physical Therapy Program, Jonathan Madamba, Walker Riley, Isaiah Taylor
UNLV Theses, Dissertations, Professional Papers, and Capstones
Purpose/Methods: The goal of this study is to analyze the effect of an in-person interview on the admission of minority applicants into the Doctor of Physical Therapy (DPT) program at the University of Nevada, Las Vegas (UNLV). Using data from the 2014-2022 admissions cycles we assessed inter-rater reliability of the interviewer’s, differences in average in-person interview score between racial groups, and compared the difference in pre-interview scores between racial groups.
Results: We found that students identifying as Black scored higher on interviews than their White counterparts. However, a smaller proportion of them matriculated into the program due to the difference …
Pre-Service Teacher Self-Efficacy For Classroom Management And Evidence Based Practices For Managing Classroom And Challenging Behaviors, Mathew Benthin
Pre-Service Teacher Self-Efficacy For Classroom Management And Evidence Based Practices For Managing Classroom And Challenging Behaviors, Mathew Benthin
UNLV Theses, Dissertations, Professional Papers, and Capstones
This study investigated the relationship between pre-service teachers' self-efficacy (TSE) and their knowledge of evidence-based practices. Teacher self-efficacy, defined as the belief in one's ability to achieve specific teaching goals, plays a pivotal role in shaping teaching behaviors and student outcomes. Evidence-based practices, grounded in scientific research, are essential for effective teaching and problem-solving in diverse classroom settings. This study highlighted the importance of the two specific resources of self-efficacy and knowledge of evidence-based practices for managing classrooms and challenging behaviors. By exploring pre-service teacher resources, this study aimed to contribute to the body of literature exploring the challenges facing …
Bridging The Gap: A Quality Improvement Initiative To Enhance Interoception Resources For Pediatric Oncology Ots, Dana Louise Lomotan Doolittle
Bridging The Gap: A Quality Improvement Initiative To Enhance Interoception Resources For Pediatric Oncology Ots, Dana Louise Lomotan Doolittle
UNLV Theses, Dissertations, Professional Papers, and Capstones
Chemotherapy administered to children and youth diagnosed with pediatric cancers may induce side effects such as pain, fatigue, anxiety, and other distressing symptoms that could impact the ability to meet occupational needs and desires in daily functioning. The occupational therapy discipline incorporates mindfulness strategies to target these symptoms for increased body awareness in children with cancer, though interoception’s role within the pediatric oncology population is obscure. Furthermore, there are implicated demands described in the literature for more established pediatric oncology rehabilitation programs to attend to the specific needs of the population and to advocate for occupational therapy’s role in the …
Chronic Exposure To Porphyromonas Gingivalis Disrupts Macrophage Innate Immune Responses, Corey Allen Foulk
Chronic Exposure To Porphyromonas Gingivalis Disrupts Macrophage Innate Immune Responses, Corey Allen Foulk
UNLV Theses, Dissertations, Professional Papers, and Capstones
Introduction: Porphyromonas gingivalis (Pg) is a pathogenic, “red-complex” bacteria found in higher concentrations in advanced gingivitis and periodontitis. Macrophages are capable of adopting numerous phenotypes depending on the surrounding environment. Classic M1 macrophages are the result of inflammatory signals including IFNγ. This study investigated whether naïve M0 macrophages can transition into classic M1 macrophages following stimulation with traditional agonists after cells have been exposed to formalin killed P. gingivalis.Methods: The THP-1 monocytes were differentiated into naïve macrophages (M0) using PMA treatment. The M0 cells were challenged with formalin killed P. gingivalis for 24 hours. After prolonged exposure to P. gingivalis, …
Patterns In Antibiotic Susceptibility Before And After Covid-19, Jessica Freely
Patterns In Antibiotic Susceptibility Before And After Covid-19, Jessica Freely
UNLV Theses, Dissertations, Professional Papers, and Capstones
The COVID-19 pandemic led to a surge in antibiotic use, despite the viral nature of the disease. This widespread and often unnecessary use of antibiotics poses a serious threat on global health by accelerating the development of antibiotic resistance. Healthcare professionals utilize strategies, including Antibiotic Stewardship Programs (ASPs) and the use of antibiograms to mitigate the growing threat of antibiotic resistance. Antibiograms are tools used in healthcare settings to summarize and track bacterial susceptibility to various antibiotics. They provide clinicians critical information to guide selection of effective antibiotic treatment and monitor resistance trends overtime. The Centers for Disease Control and …
Acquired Brain Injury Education: Utilizing Unfolding Case Studies To Improve Critical Thinking Skills In Occupational Therapy Students, Katherine Hathaway
Acquired Brain Injury Education: Utilizing Unfolding Case Studies To Improve Critical Thinking Skills In Occupational Therapy Students, Katherine Hathaway
UNLV Theses, Dissertations, Professional Papers, and Capstones
Acquired brain injuries (ABI), including traumatic brain injury, stroke, and anoxia, affect millions worldwide, and often result in long-term impairments in daily functioning. Despite the need for specialized, ongoing care, many individuals with ABI lack access to adequate long-term rehabilitation services, and families report substantial caregiver burden due to limited resources and poor care coordination. Occupational therapy plays a critical role in meeting the needs of this population; however, many entry-level practitioners feel underprepared to manage the complex challenges associated with ABI, largely due to limited training and exposure. This capstone project aimed to address this educational gap by implementing …
Oral Prevalence Of Selenomonas Noxia Differs Among Orthodontic Patients Compared To Non-Orthodontic Controls: A Retrospective Biorepository Analysis, Kyle Hodges
UNLV Theses, Dissertations, Professional Papers, and Capstones
Introduction: The introduction of fixed orthodontic brackets in orthodontic therapy has the potential to significantly alter the oral microbial flora. Most orthodontic research has focused on cariogenic pathogens, while some evidence has demonstrated an increase in many known periodontal pathogens. However, little is known about the prevalence of the gram-negative periodontal pathogen, Selenomonas noxia (SN) among these patients.Methods: Using an existing saliva biorepository, n=208 samples from adult and pediatric orthodontic and non-orthodontic patients were identified and screened for the presence of SN using qPCR and validated primers. Results: In the pediatric study sample (n=89) 36% tested positive for the presence …
Assessing The Effects Of Streptozotocin-Induced Hyperglycemia On Amyloid Beta Accumulation And Cognitive Behavior In A Mouse Model Of Alzheimer’S Disease-Related Pathology, Andrew Adonay Ortiz
Assessing The Effects Of Streptozotocin-Induced Hyperglycemia On Amyloid Beta Accumulation And Cognitive Behavior In A Mouse Model Of Alzheimer’S Disease-Related Pathology, Andrew Adonay Ortiz
UNLV Theses, Dissertations, Professional Papers, and Capstones
Alzheimer’s disease (AD) is an irreversible and devastating neurodegenerative disease characterized by progressive synaptic, dendritic, glial, and neuronal loss, collectively leading to impairments in learning, memory, and deterioration of cognitive and behavioral functions. AD is the most common form of dementia accounting for 60-80% of all cases. AD affects approximately 7 million Americans and is the 6th leading cause of death in the US. Furthermore, by 2050, the US is projected to spend over $1.1 trillion on AD-related treatments. Pathological hallmarks of AD include beta-amyloid (Aβ) plaques, intracellular neurofibrillary tangles (NFTs), and chronic neuroinflammation, which can promote and exacerbate both …
Detection And Quantification Of Total Airborne Fungi And Coccidioides Species In Environmental Samples, Theresa T. Roehr
Detection And Quantification Of Total Airborne Fungi And Coccidioides Species In Environmental Samples, Theresa T. Roehr
UNLV Theses, Dissertations, Professional Papers, and Capstones
Fungal exposure can cause acute and chronic illnesses or exacerbate existing illnesses. Some fungi are opportunistic pathogens and can lead to serious systemic fungal infections. In 2020, more than 150 million cases of severe fungal infections were reported globally resulting in an estimated 1.7 million deaths. Coccidioidomycosis, or Valley fever, is classified as a serious fungal infection caused by the fungi Coccidioides immitis and C. posadasii. These particular fungi are prevalent in the soil of the Southwestern United States, including Las Vegas, Nevada. In 2024, there were a total of 269 cases of Valley fever reported in Nevada, and …
Torque Efficacy Of Cadmus Bracket Design Using Clear Aligners, Joseph Soderberg
Torque Efficacy Of Cadmus Bracket Design Using Clear Aligners, Joseph Soderberg
UNLV Theses, Dissertations, Professional Papers, and Capstones
Introduction: Clear aligner therapy (CAT) is an alternative option for clinicians to use for orthodontic treatment as opposed to fixed appliances. Many patients prefer clear aligner therapy due to its esthetic looks, removability, ease of oral hygiene, and comfort. Clear aligner companies boast to clinicians that it can be used more efficiently and effectively than fixed appliances in many orthodontic cases. Although these claims have been made, there is a lack of evidence to prove that clear aligner therapy is more efficient or effective. This research will focus on torque control. This project is designed around a new, pre-manufactured attachment …
Peripheral Neuroimmune Mechanisms Of Chronic Back Pain, Aleyah Esther Goins
Peripheral Neuroimmune Mechanisms Of Chronic Back Pain, Aleyah Esther Goins
Biomedical Sciences ETDs
Chronic back pain (CBP) affects 1 in 10 people worldwide, reducing mobility, productivity, and quality of life. Despite its prevalence, non-addictive treatments remain limited due to an incomplete understanding of chronic pain mechanisms. This dissertation examines peripheral neuroimmune interactions in CBP using a urokinase-type plasminogen activator (uPA)-induced mouse model (uPA-CBP). uPA, a pro-inflammatory serine protease, was injected into the L2/L3 lumbar spinous ligament, inducing prolonged mechanical and cold hypersensitivity. Flow cytometry of dorsal root ganglia (DRG) showed increased CD45+CD11b+ myeloid cells in males and CD45+CD3+CD4+ lymphocytes in females. DRG neurons from male uPA-CBP mice exhibited heightened action potential firing. Pharmacological …
St6galnac-I Regulates Tumor Cell Sialylation Via Nectin2/Muc5ac-Mediated Immunosuppression And Angiogenesis In Non-Small Cell Lung Cancer, Muthamil Iniyan Appadurai, Sanjib Chaudhary, Ashu Shah, Gopalakrishnan Natarajan, Zahraa W. Alsafwani, Parvez Khan, Dhananjay D. Shinde, Subodh M. Lele, Lynette M. Smith, Mohd W. Nasser, Surinder K. Batra, Apar Kishor Ganti, Imayavaramban Lakshmanan
St6galnac-I Regulates Tumor Cell Sialylation Via Nectin2/Muc5ac-Mediated Immunosuppression And Angiogenesis In Non-Small Cell Lung Cancer, Muthamil Iniyan Appadurai, Sanjib Chaudhary, Ashu Shah, Gopalakrishnan Natarajan, Zahraa W. Alsafwani, Parvez Khan, Dhananjay D. Shinde, Subodh M. Lele, Lynette M. Smith, Mohd W. Nasser, Surinder K. Batra, Apar Kishor Ganti, Imayavaramban Lakshmanan
Journal Articles: Biochemistry & Molecular Biology
Glycosylation controls immune evasion, tumor progression, and metastasis. However, how tumor cell sialylation regulates immune evasion remains poorly characterized. ST6GalNAc-I, a sialyltransferase that conjugates sialic acid to the glycans in glycoproteins, was overexpressed in an aggressive-type KPA (KrasG12D/+ Trp53R172H/+ Ad-Cre) lung adenocarcinoma (LUAD) model and patient samples. Proteomic and biochemical analysis indicated that ST6GalNAc-I mediated NECTIN2 sialylation in LUAD cells. ST6GalNAc-I-deficient tumor cells cocultured with T cells were more susceptible to T cell-mediated tumor cell killing, indicating a key role for NECTIN2 in T cell dysfunction. Mice injected with St6galnac-I-knockdown syngeneic cells showed reduced lung tumor incidence and Nectin2/Tigit-associated immunosuppression. …
The Effects Of Sugar Alcohols On The Growth Of Cariogenic Bacteria, Jake Sanders Boone
The Effects Of Sugar Alcohols On The Growth Of Cariogenic Bacteria, Jake Sanders Boone
UNLV Theses, Dissertations, Professional Papers, and Capstones
The purpose of this study was to examine the potential of sugar alcohols, commonly used as sugar substitutes to reduce the activity of dental caries causing bacteria. Specifically, the sugar alcohols xylitol, erythritol, sorbitol, and mannitol were placed into the growth media of Streptococcus mutans and Lactobacillus acidophilus. The effects on their bacterial growth were observed. 10% xylitol, 10% erythritol, 10% sorbitol, 10% mannitol, 5% xylitol + 5% erythritol, and 3.3% erythritol + 3.3% xylitol + 3.3% sorbitol combinations were compared to the control groups for differences in bacterial growth. S. mutans samples were significantly inhibited by all groups except …
Enhancing Documentation Proficiency: Feasibility Of Integrating Ehr Go & Unfolding Case Studies In Occupational Therapy Education, Jeffery D. Holland Jr.
Enhancing Documentation Proficiency: Feasibility Of Integrating Ehr Go & Unfolding Case Studies In Occupational Therapy Education, Jeffery D. Holland Jr.
UNLV Theses, Dissertations, Professional Papers, and Capstones
Objective: This capstone project evaluated the feasibility of integrating EHR Go and Unfolding Case Studies (UCS) into the first-year curriculum of the University of Nevada, Las Vegas (UNLV) Occupational Therapy Doctorate (OTD) program. The goal was to enhance students’ SOAP (Subjective, Objective, Assessment, Plan) note documentation proficiency and critical thinking skills through simulation-based learning and increased exposure to real-world documentation expectations and examples. Feedback from 33 clinicians at Dignity Health St. Rose Dominican Hospital – Siena Campus informed the workshop design, and OTD faculty and graduate assistants at UNLV provided input on curriculum integration feasibility.Methods: A quasi-experimental, non-equivalent groups pretest-posttest …
Clinical Benefit Analysis Of Modified Motion Management Protocols, Dyanne S. Macalinao
Clinical Benefit Analysis Of Modified Motion Management Protocols, Dyanne S. Macalinao
UNLV Theses, Dissertations, Professional Papers, and Capstones
Radiation therapy is crucial for treating cancer, using ionizing radiation to target and destroy cancer cells. This radiation is produced by machines like linear accelerators or through natural radioactive decay. Radiation therapy treatment planning involves prescribing doses and contouring target areas. However, managing tumors that move with breathing, such as in the lungs, remains a major challenge. Tumor motion exceeding 5 mm, as outlined in the AAPM’s Task Group 76, can compromise treatment accuracy, risking underdosing the tumor and overdosing healthy tissue. This issue is especially critical in high dose treatments like stereotactic body radiation therapy (SBRT). TG-76 provides different …
Prevalence Of Cardiovascular-Kidney-Metabolic Stages In Us Adolescents And Relationship To Social Determinants Of Health, Carissa M. Baker-Smith, Abigail M. Gauen, Lucia C. Petito, Sadiya S. Khan, Norrina B. Allen
Prevalence Of Cardiovascular-Kidney-Metabolic Stages In Us Adolescents And Relationship To Social Determinants Of Health, Carissa M. Baker-Smith, Abigail M. Gauen, Lucia C. Petito, Sadiya S. Khan, Norrina B. Allen
Department of Pediatrics Faculty Papers
BACKGROUND: Risk factors for atherosclerotic cardiovascular disease begin in youth. Knowledge of the prevalence of cardio-kidney-metabolic (CKM) syndrome in adolescents and its risk factors is critical to understanding the cause of atherosclerotic cardiovascular disease risk burden.
METHODS: We conducted a cross-sectional analysis of the 2017 to 2020 US National Health and Nutrition Examination Survey data and determined the prevalence of each CKM stage in adolescents aged 12 to 18 years. We then assessed the relationship between the family income-to-poverty ratio, health insurance, routine health care access, food security, health behaviors, and CKM stage. We quantified associations between social factors, behaviors, …
The Identification Of Xpr1 As A Voltage- And Phosphate-Activated Phosphate-Permeable Ion Channel, Hongjiang Wu, Liang Sun, Tong Huo, Theodore G Wensel, Frank T Horrigan, Zhao Wang
The Identification Of Xpr1 As A Voltage- And Phosphate-Activated Phosphate-Permeable Ion Channel, Hongjiang Wu, Liang Sun, Tong Huo, Theodore G Wensel, Frank T Horrigan, Zhao Wang
Faculty, Staff and Students Publications
Maintaining a balance of inorganic phosphate (Pi) is vital for cellular functionality. Proper phosphate levels are managed through Pi import and export; and the processes governing Pi export remain the least understood. Xenotropic and Polytropic retrovirus Receptor 1 (XPR1) has been identified as the only known Pi export protein in mammals. In this study, we introduce the cryogenic electron microscopy structure of human XPR1 (hXPR1), unveiling a structural arrangement distinct from that of any known ion transporter. Our structural results suggest that hXPR1 may operate as an ion channel, a hypothesis supported by patch clamp recordings revealing hXPR1's voltage- and …
The Influence Of Intrinsic Foot Muscles In Modulating Foot Shape Relative To Substrate And The Efficacy Of Different Strengthening Approaches, Luke R. Lotsis
The Influence Of Intrinsic Foot Muscles In Modulating Foot Shape Relative To Substrate And The Efficacy Of Different Strengthening Approaches, Luke R. Lotsis
Masters Theses, 2020-current
Cross-sloped surfaces create an asymmetrical substrate for foot contact, introducing a slip force within the transverse plane and a gravitational pull within the coronal plane that increases the tendency to topple downslope. To maintain stability, the foot must make structural adjustments across the hindfoot, midfoot, forefoot, and hallux. In chapter 1, I investigated how IFMs respond to varying substrate conditions and balance demands, providing insight into their functional role in maintaining stability and adapting foot structure in static and dynamic locomotor tasks. Twenty-four healthy adults participated in a series of dynamic walking trials on flat, cross-sloped and sandy substrates and …
Ubiquitin-Conjugating Enzyme Ube2n Modulates Proteostasis In Immunoproteasome-Positive Acute Myeloid Leukemia, Chiharu Ishikawa, Laura Barreyro, Avery M Sampson, Kathleen M Hueneman, Kwangmin Choi, Sophia Y Philbrook, Issac Choi, Lyndsey C Bolanos, Mark Wunderlich, Andrew G Volk, Stephanie S Watowich, Kenneth D Greis, Daniel T Starczynowski
Ubiquitin-Conjugating Enzyme Ube2n Modulates Proteostasis In Immunoproteasome-Positive Acute Myeloid Leukemia, Chiharu Ishikawa, Laura Barreyro, Avery M Sampson, Kathleen M Hueneman, Kwangmin Choi, Sophia Y Philbrook, Issac Choi, Lyndsey C Bolanos, Mark Wunderlich, Andrew G Volk, Stephanie S Watowich, Kenneth D Greis, Daniel T Starczynowski
Faculty, Staff and Student Publications
Altered protein homeostasis through proteasomal degradation of ubiquitinated proteins is a hallmark of many cancers. Ubiquitination, coordinated by E1, E2, and E3 enzymes, involves up to 40 E2-conjugating enzymes in humans to specify substrates and ubiquitin linkages. In a screen for E2 dependencies in acute myeloid leukemia (AML), ubiquitin conjugating enzyme E2 N (UBE2N) emerged as the top candidate. To investigate UBE2N's role in AML, we characterized an enzymatically defective mouse model of UBE2N, revealing UBE2N's requirement in AML without an impact on normal hematopoiesis. Unlike other E2s, which mediate lysine-48 (K48) polyubiquitination and degradation of proteins, UBE2N primarily synthesizes …
Commencement, South Georgia (2025), Philadelphia College Of Osteopathic Medicine
Commencement, South Georgia (2025), Philadelphia College Of Osteopathic Medicine
Commencements
South Georgia Campus Commencement Program, 2025. Degrees include Doctor of Osteopathic Medicine and Master of Science in Biomedical Sciences.
Commencement Speaker: Joseph A. Giaimo, DO '87.
Piloting The Inclusion Of Dollar Stores In The Modified Retail Food Environment Index (Mrfei) In Urban Clark County, Nevada, Tiana T. Tu
UNLV Theses, Dissertations, Professional Papers, and Capstones
Food insecurity is the condition of having limited or uncertain access to adequate food. It contributes to poor diet-related health outcomes which are in turn influenced by the food environment. The Centers for Disease Control and Prevention (CDC) developed the Modified Retail Food Environment Index (mRFEI) to characterize food environments by measuring the proportion of healthy and non-healthy retailers. The CDC mRFEI considers a variety of establishments but fails to include dollar stores, which contribute to the food environment by offering food and, in some cases, fresh produce. This study proposed an “expanded mRFEI” that modified the CDC mRFEI methodology …
The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons Of The Transcriptomic Landscapes Across Mouse Models, Ling Cai, Fangjiang Wu, Qinbo Zhou, Ying Gao, Bo Yao, Ralph J Deberardinis, George K Acquaah-Mensah, Vassilis Aidinis, Jennifer E Beane, Shyam Biswal, Ting Chen, Carla P Concepcion-Crisol, Barbara M Grüner, Deshui Jia, Robert A Jones, Jonathan M Kurie, Min Gyu Lee, Per Lindahl, Yonathan Lissanu, Corina Lorz, David Macpherson, Rosanna Martinelli, Pawel K Mazur, Sarah A Mazzilli, Shinji Mii, Herwig P Moll, Roger A Moorehead, Edward E Morrisey, Sheng Rong Ng, Matthew G Oser, Arun R Pandiri, Charles A Powell, Giorgio Ramadori, Mirentxu Santos, Eric L Snyder, Rocio Sotillo, Kang-Yi Su, Tetsuro Taki, Kekoa Taparra, Phuoc T Tran, Yifeng Xia, J Edward Van Veen, Monte M Winslow, Guanghua Xiao, Charles M Rudin, Trudy G Oliver, Yang Xie, John D Minna
The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons Of The Transcriptomic Landscapes Across Mouse Models, Ling Cai, Fangjiang Wu, Qinbo Zhou, Ying Gao, Bo Yao, Ralph J Deberardinis, George K Acquaah-Mensah, Vassilis Aidinis, Jennifer E Beane, Shyam Biswal, Ting Chen, Carla P Concepcion-Crisol, Barbara M Grüner, Deshui Jia, Robert A Jones, Jonathan M Kurie, Min Gyu Lee, Per Lindahl, Yonathan Lissanu, Corina Lorz, David Macpherson, Rosanna Martinelli, Pawel K Mazur, Sarah A Mazzilli, Shinji Mii, Herwig P Moll, Roger A Moorehead, Edward E Morrisey, Sheng Rong Ng, Matthew G Oser, Arun R Pandiri, Charles A Powell, Giorgio Ramadori, Mirentxu Santos, Eric L Snyder, Rocio Sotillo, Kang-Yi Su, Tetsuro Taki, Kekoa Taparra, Phuoc T Tran, Yifeng Xia, J Edward Van Veen, Monte M Winslow, Guanghua Xiao, Charles M Rudin, Trudy G Oliver, Yang Xie, John D Minna
Faculty, Staff and Student Publications
Lung cancer, the leading cause of cancer mortality, exhibits diverse histological subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung cancer, but data from these models are disparate, siloed, and difficult to compare in a centralized fashion. In this study, we established the Lung Cancer Autochthonous Model Gene Expression Database (LCAMGDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets covering 974 samples from genetically engineered mouse models (GEMMs), 368 samples from carcinogen-induced models, and 12 samples from a spontaneous model. Meticulous curation and collaboration with data depositors produced a robust and comprehensive database, …
G-Quadruplex Stabilizer Cx-5461 Effectively Combines With Radiotherapy To Target Α-Thalassemia/Mental Retardation X-Linked-Deficient Malignant Glioma, Sharvari Dharmaiah, Prit Benny Malgulwar, William E Johnson, Brandon A Chen, Vladislav Sharin, Benjamin T Whitfield, Christian Alvarez, Vasudev Tadimeti, Ahsan S Farooqi, Jason T Huse
G-Quadruplex Stabilizer Cx-5461 Effectively Combines With Radiotherapy To Target Α-Thalassemia/Mental Retardation X-Linked-Deficient Malignant Glioma, Sharvari Dharmaiah, Prit Benny Malgulwar, William E Johnson, Brandon A Chen, Vladislav Sharin, Benjamin T Whitfield, Christian Alvarez, Vasudev Tadimeti, Ahsan S Farooqi, Jason T Huse
Faculty, Staff and Student Publications
Background: Inactivation of α-thalassemia/mental retardation X-linked (ATRX) represents a defining molecular feature in large subsets of malignant glioma. ATRX deficiency gives rise to abnormal G-quadruplex (G4) DNA secondary structures, enhancing replication stress and genomic instability. Building on earlier work, we evaluated the extent to which pharmacological G4 stabilization selectively enhances DNA damage and cell death in ATRX-deficient preclinical glioma models.
Methods: Using the G4 stabilizer CX-5461, we treated patient-derived glioma stem cells (GSCs) in vitro and GSC flank and intracranial murine xenografts in vivo to evaluate efficacy as both a single agent and in combination with ionizing radiation (IR), the …
Enhancing Motor Function In Individuals With Lower Limb Amputation Through Peerbased Learning Of Balance And Fall Recovery Skills, Zoe Castle, Jer Ja Chuang, Jewel Granados, Danna Shaw
Enhancing Motor Function In Individuals With Lower Limb Amputation Through Peerbased Learning Of Balance And Fall Recovery Skills, Zoe Castle, Jer Ja Chuang, Jewel Granados, Danna Shaw
UNLV Theses, Dissertations, Professional Papers, and Capstones
Purpose: Lower limb amputation (LLA) is a devastating condition that is becoming more prevalent in the United States. We examined the effects of peer-based action observation learning on the brain activation and the eyetracking pattern in individuals with LLA.
Methods: Fourteen individuals with LLA (51.9±12.6 years, 4 females, 9 with transfemoral amputations) were asked to learn a balance task through observing the movements demonstrated by individuals with LLA or persons with intact limbs. Electroencephalogram (EEG) signals, visual attention time, and peak saccade velocity were recorded when participants watched the demonstration videos. Power spectral density (PSD) was used to analyze the …