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Liger-Hn Phase Iii Trials Of Petosemtamab + Pembrolizumab And Petosemtamab Monotherapy In Recurrent Or Metastatic Hnscc, Jean-Pascal Machiels, Douglas Adkins, Et Al.

2020-Current year OA Pubs

Patients with recurrent/metastatic (r/m) head and neck squamous cell carcinoma (HNSCC) have limited treatment options and a dismal prognosis, especially when their cancer is resistant to standard treatments like anti-programmed cell death protein 1 and platinum-based therapies. Petosemtamab - a human, common light chain, bispecific antibody with enhanced antibody-dependent cellular cytotoxicity targeting epidermal growth factor receptor (EGFR) and leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) - demonstrated antitumor activity in r/m HNSCC. In many tumor types, including HNSCC, EGFR is an oncogenic driver, while LGR5 is upregulated. LGR5 can potentiate the wingless-type integration site (WNT)/β-catenin signaling pathway in response to …

Mayo Normative Studies: Regression-Based Normative Data For Remote Self-Administration Of The Stricker Learning Span, Symbols Test, And Mayo Test Drive Screening Battery Composite And Validation In Individuals With Mild Cognitive Impairment And Dementia, Nikki H Stricker, Jason Hassenstab, Et Al.

2020-Current year OA Pubs

No abstract provided.

Projection-Tags Enable Multiplex Projection Tracing And Multi-Modal Profiling Of Projection Neurons, Lite Yang, Fang Liu, Hannah Hahm, Takao Okuda, Xiaoyue Li, Yufen Zhang, Vani Kalyanaraman, Monique R Heitmeier, Vijay K Samineni

2020-Current year OA Pubs

Single-cell multiomic techniques have sparked immense interest in developing a comprehensive multi-modal map of diverse neuronal cell types and their brain-wide projections. However, investigating the complex wiring diagram, spatial organization, transcriptional, and epigenetic landscapes of brain-wide projection neurons is hampered by the lack of efficient and easily adoptable tools. Here we introduce Projection-TAGs, a retrograde AAV platform that allows multiplex tagging of projection neurons using RNA barcodes. By using Projection-TAGs, we performed multiplex projection tracing of the cortex and high-throughput single-cell profiling of the transcriptional and epigenetic landscapes of the cortical projection neurons in female mice. Projection-TAGs can be leveraged …

Landscape Of Cancer Associated Epcam Mutations: Molecular Modeling, Predictive Insights And Impact On Patient Survival, Priyanka S Dhotare, Audrey C Bochi-Layec, Timothy P Fleming, William E Gillanders, Ross M Bremner, Kailas D Sonawane, Narendra V Sankpal

2020-Current year OA Pubs

BACKGROUND: EpCAM (epithelial cell adhesion molecule) is a key regulator of epithelial cell-cell adhesion, signal transduction, tissue regeneration, and serves as a stem cell marker. It is frequently overexpressed in epithelial cancers and is linked to tumor progression, survival, and metastasis. However, the functional impact of EpCAM mutations in cancer remains poorly understood.

METHODS: To investigate the role of EpCAM mutations, we performed a comprehensive analysis of cancer cohorts from multiple genomic datasets, identifying novel somatic EpCAM mutations across diverse epithelial cancers. Using bioinformatics tools (SIFT, PolyPhen-2, Mutation Assessor) and molecular modeling, we assessed the potential impact of these mutations. …

Cardiac Transplantation Does Not Improve Exercise Tolerance, Muscle Mass, Or Substrate Metabolism In Barth Syndrome, W Todd Cade, Kathryn L Bohnert, Linda R Peterson, Lisa De Las Fuentes, Emily Poehlein, Cynthia L Green, Christina A Pacak, Barry J Byrne, Dominic N Reeds, Adil Bashir, Brian Feingold, Carolyn Taylor

2020-Current year OA Pubs

Barth syndrome (BTHS) is a rare X-linked recessive disorder characterized by mutations in the TAFAZZIN gene, leading to mitochondrial dysfunction, cardioskeletal myopathy, neutropenia, exercise intolerance, and growth delay. While cardiac transplantation can improve heart function in BTHS patients, the metabolic effects of this procedure remain poorly understood. This study aimed to compare skeletal muscle morphology, substrate metabolism, energetics, and exercise tolerance in individuals with BTHS who had undergone cardiac transplantation (BTHS-T) versus BTHS patients without transplantation (BTHS-noT) and healthy controls. Six (

Clinical Evaluation Of The Healgen Rapid Covid-19 Antigen Test As A Point-Of-Care Diagnostic Tool, Stephen A Young, Hua Zhang, Jose Rodriguez, David Mishkin, Ward Paine, Li Seyfried, Latisha Hargrove, Dennis L Broyles, Chermaen Lindberg, Anurag Purushothaman, Stacey House

2020-Current year OA Pubs

BACKGROUND: Development of readily available Rapid COVID-19 Antigen tests essential for promptly identifying SARS-CoV2 infection and preventing its spread.

METHODS: This study evaluated the clinical performance of the Healgen Rapid COVID-19 antigen test as a point-of-care diagnostic tool with 806 evaluable subjects who were within 6 days post-symptom onset. The results from the Healgen test were compared to the results from Emergency Use Authorization (EUA) approved SARS-CoV-2 RT-PCR tests.

RESULTS: Out of the 806 evaluable subjects, 140 tested positive and 640 tested negative for SARS-CoV-2 with the Healgen COVID-19 test, showing good agreement with the EUA RT-PCR results. There were …

Individualized Functional And Structural Language Lateralities In Temporal Lobe Epilepsy And Their Impact On Memory, Ankeeta Ankeeta, Qirui Zhang, Sam Sharifzadeh Javidi, Shilpi Modi, Michael R. Sperling, Joseph I. Tracy

Department of Neurology Faculty Papers

The basis and impact of functional asymmetries in the brain, particularly language lateralization, are not fully understood, and the relationship between functional and structural asymmetries remains largely untested. This study investigated the degree to which asymmetries in hemispheric language laterality are concordant with asymmetries in gray matter (GM) structure and whether the hemispheric organization of memory is influenced by functional language asymmetries. Structural and functional MR data was acquired from 261 individuals, including those with unilateral temporal lobe epilepsy (LTLE = 96, RTLE = 69) and matched with healthy participants (HPs = 96). Functional language laterality indices (LIs) were calculated …

Interprofessional Education Confidence In Health Professions Education Assessment: Are Learners Ready For Interprofessional Collaborative Practice?, Nicole E. Brown, Anthony J. Goreczny, Natalie Schirato, Jodi Schreiber, Sarah Jameson, Timothy Braun, Mary Dee Fisher

Internet Journal of Allied Health Sciences and Practice

Purpose: Interprofessional education (IPE) is critical to developing skills necessary for interprofessional collaborative practice (IPCP). Although much IPE research focuses on competence as an outcome, little research examines learner confidence in competence, which is likely to translate didactic knowledge into application of clinical skills. The current study aimed to assess student levels of confidence in skill competence related to the Interprofessional Education Collaborative (IPEC) core competencies. Methods: Students from multiple health professions programs (nursing, occupational therapy, physical therapy, physician assistant, graduate psychology), graduate biology, and undergraduate programs participated in the study (N=188). The Interprofessional Education Evaluation of Confidence (IPEEC) …

The Current Status Of Multi-Modality Imaging Of Pulmonary Emboli, Rodney C. Fisher, Kimberly L. Onstott

Internet Journal of Allied Health Sciences and Practice

Background: Pulmonary emboli (PE) have a significant incident rate of 112.3 per 100,000 adults. When age-weighted, the population over 75 has an incident rate of 1 out of 100. 90% of deaths from acute cases occur within two hours of the onset of symptoms. In pregnancy-related deaths, 20% are attributed to PE, and pregnancy increases the risk of the development of PE by 400 – 600%. Significant risk factors for PE include COPD, obesity, recent trauma or surgery, a history of deep vein thrombosis (DVT), a history of hormonal therapy, smoking, and pregnancy. Purpose: This literature review discusses how PE …

Persistent Lichenoid Reaction And Eruptive Keratoacanthomas Following Pd-1 Inhibitor Therapy, Paul Vance, Michael Hohnadel

HCA Healthcare Journal of Medicine

Background

Immune checkpoint inhibitors, such as nivolumab, have become integral in treating metastatic malignancies by enhancing immune responses against tumors. However, they are associated with immune-related adverse events (irAEs), including cutaneous reactions. We report a case of persistent lichenoid dermatitis during therapy and eruptive keratoacanthomas (KAs) following the cessation of nivolumab.

Case Presentation

A 77-year-old Caucasian man presented with a subcutaneous melanoma on the left lateral chest, treated with excision followed by adjuvant nivolumab. Seven weeks into therapy, he developed pruritic erythematous macules, forming patches on his forearms, later spreading to his trunk. Biopsy confirmed lichenoid dermatitis. Treatment with triamcinolone …

Unraveling The Threads: A Case Report On Confusional Migraine And The Intricate Dance Between Psychiatry And Neurology, Mabit C. Gonzalez, Manjula Kottapalli

HCA Healthcare Journal of Medicine

Background

Migraine affects about 1 billion people worldwide and is associated with a significant negative impact on personal and occupational functioning. Migraine accompanied by aura is seen in about 15% of migraineurs. Visual aura is the most common type of aura. Much less common though are auras that involve higher mental function, such as confusional state. The confusional state may manifest with a wide variety of cortical dysfunction, such as speech impairment, increased alertness, agitation, and amnesia, often lasting longer than a typical migraine aura.

Case Presentation

The authors present the unique case of a 29-year-old patient with episodic and …

Neurosarcoidosis Presenting As Cauda Equina Syndrome: Case Report And Review Of The Literature, Benjamin Millar, Lauren Carmody, Fnu Naintara, Tara Dutta, Abhinav Hoskote

Transformative Medicine

Background

Sarcoidosis is a systemic immune disease with an unknown trigger, identified histologically by non-caseating granulomas. Neurosarcoidosis is a subset in which granulomatous inflammation infiltrates the central or peripheral nervous system. Sarcoid myelopathy affects a very small fraction of sarcoidosis patients. We present here the case of a 35 year old male who presented primarily for cauda equina symptoms.

Case Presentation

A 35-year-old Caucasian male with past history of hypertension, Hashimoto's thyroiditis, and type II diabetes mellitus presented to the emergency department complaining of a headache with left sided face numbness and periorbital swelling. He reported two months of gradual, …

Phytochemical Analysis And Antimicrobial Activity Of Micromeria Barbata Leaf And Stem Extracts Against Pseudomonas Aeruginosa: Insights From Molecular Docking And In Vitro Assays, Shiraz Rawas, Dalia El-Badan, Nawal Al Hakawati

BAU Journal - Science and Technology

The present study provides the characterization of the phytochemical content and the antibacterial activity of ethanolic extracts from the leaves (LM) and stems (SM) of Micromeria barbata (M.barbata) against Pseudomonas aeruginosa . Important functional groups were determined by analyzing the FTIR spectra of LM and SM. The phytochemical profiles were analyzed by GC-MS, and these characterized the chemicals according to retention periods and peak regions. The binding affinities of discovered compounds with the P. aeruginosa LasR and PqsD proteins were evaluated using molecular docking approach. Assays for biofilm formation, MIC, MBC, and agar well diffusion were used to assess the …

Hubungan Penggunaan Jenis Bahan Bakar Untuk Memasak Dengan Kejadian Ispa Pada Balita Di Provinsi Kalimantan Utara Tahun 2017, Maharani Karina Setiawan, Salwa Zalfa Elyanto, Aisyah Muthia Darajat, M. Nanda Putra Pratama Sm

Jurnal Nasional Kesehatan Lingkungan Global

Acute respiratory infections (ARI) in toddlers are certainly still a significant public health problem with environmental factors affecting them, such as air pollution from the burning of the fuels used, namely charcoal, wood and kerosene. This study aims to analyze the relationship between household fuel use and the incidence of ISPA in toddlers, especially in North Kalimantan Province (Kaltara) using data from the Indonesian Health Demographic Survey (SDKI) in 2017. The research design used a cross-sectional study, data analysis was carried out descriptively using a table then followed by chi square data analysis to determine the relationship between the variable …

Faktor-Faktor Yang Berhubungan Dengan Massa Otot, Kekuatan Otot, Dan Performa Fisik Pada Lansia, Nur Riviati, Taufik Indrajaya, Rukiah Chodilawati, Ridzqie Dibyantari, Bima Indra

Jurnal Penyakit Dalam Indonesia

Introduction. Despite its high prevalence and significant impact on health, comprehensive studies are still needed to explore the factors affecting sarcopenia parameters, such as muscle mass, muscle strength, and physical performance. This study aimed to identify the factors influencing sarcopenia parameters in the elderly, including muscle mass, muscle strength, and physical performance.

Methods. A cross-sectional study was conducted from July to December 2022 on elderly individuals (>60 years old) at the Geriatric Polyclinic, Moh. Hoesin General Hospital, Palembang, selected through consecutive sampling. Muscle mass was measured using bioimpedance analysis, expressed in ASMI values; muscle strength was measured …

Spatially Resolved Transcriptomic Profiles Of Placental Cell Populations In Placental Malaria, Corina A. Mong

Undergraduate Honors Theses

Malaria remains a prevalent infectious disease that continues to cause disease-related morbidity and mortality. Despite preventative efforts, malarial pregnancies still cause birth complications, therefore emphasizing the necessity to study these adverse outcomes in malarial pregnancy. Malaria in pregnancy can lead to placental malaria (PM), which is the presence and accumulation of Plasmodium-infected red blood cells in the placental intervillous space (IVS). Even after treatment, past PM (presence of hemozoin crystals from the parasite in the placenta) can cause a chronic inflammatory response. We predicted that the activation states of the maternal monocytes and fetal macrophages differ within the placenta and …

The Relationship Between The Use Of Piped Drinking Water And Diarrhea: Data From The 2017 Indonesia Demographic And Health Survey (Idhs), Afifah Azharadipta, Azizah Meutia Putri Ianam, Nadya P. Febriana, Pratiwi Haryani

Jurnal Nasional Kesehatan Lingkungan Global

Access to clean water remains a global challenge. According to the World Health Organization, in 2020 unsafe water and poor sanitation contributed to approximately 485,000 deaths annually due to diarrhea; one of the leading causes of child mortality in low- and middle-income countries. In Indonesia, UNICEF reported that nearly 70% of household drinking water sources are contaminated with fecal matter, increasing the risk of diarrhea, particularly among children under five. This study aims to analyze the association between the use of piped drinking water and the incidence of diarrhea among children under five in Indonesia. A cross-sectional study design was …

Hubungan Kelayakan Sumber Air Minum Terhadap Kejadian Diare Pada Anak Balita Di Indonesia: Studi Cross-Sectional Berdasarkan Data Sdki 2017, Dessy Anggun Utami, Azkia Afiatun Najah Wahyudi, Balqis Nisrina Safari, Eni Law

Jurnal Nasional Kesehatan Lingkungan Global

Background: Diarrhea is one of the leading causes of mortality in toddlers. One of its primary causes is associated with inadequate drinking water sources. However, studies exploring this relationship remain limited, necessitating further research to determine the association between the suitability of drinking water sources and the incidence of diarrhea in children under five in Indonesia. Method: A cross-sectional design was employed, using data on children under five from households included in the 2017 Indonesia Demographic and Health Survey (SDKI). The study examined the relationship between the incidence of diarrhea and the suitability of drinking water sources. Chi-square statistical tests …

Anthropometry Measurement Video Improve Knowledge Of Cadres In Nganjuk City: A Single Group Pre-Post Test Design Study, Farah Paramita, Mika Vernicia Humairo, Septa Katmawanti, Nohan Arum Romadlona

Preventia: The Indonesian Journal of Public Health

High quality anthropometric measurements are important for nutritional assessment in children. In Indonesia, anthropometric measurement of children performed by caders in child center called posyandu as a child growth monitoring. However error measurements are found, especially on length or height measurement of children affecting presision and accuracy of data. This will lead to misinterpretation of child nutrition status. Education and training for cadres using media are important to improve their knowledge and skill related to anthropometric measurements. This study aimed to assess the effect of anthropometry measurement training using videos on Cadre’s knowledge. This study used one group pre-post test …

Too Sweet To Ignore: How Ssb Intake And Physical Inactivity Affect Bmi In Malang’S Student Population, Indana Tri Rahmawati, Nurnaningsih Herya Ulfah, Anggi Renawati, Yuvica Novita Gunawan

Preventia: The Indonesian Journal of Public Health

The growing incidence of overweight and obesity in young adults has been closely associated with unhealthy lifestyle habits, particularly the high intake of sugar-sweetened beverages (SSBs) and low levels of physical activity. College students are especially at risk due to lifestyle changes that occur during their university experience. This research aims to investigate the SSB consumption patterns, physical activity levels, and their correlation with Body Mass Index (BMI) among university students in Malang City. A descriptive cross-sectional study was carried out with 382 active students chosen through accidental sampling. Data were obtained using an online questionnaire shared through student networks …

Age-Friendly Care And Mobility In Hospitalized Older Adults With Cognitive Impairment: A Feasibility Quality Improvement Initiative, Jasmine K. Vickers, Richard E. Kennedy, Shari Harrell, David H. James, Katrina Booth, Emily Simmons, Cynthia J. Brown, Kellie L. Flood

School of Medicine Faculty Publications

BACKGROUND: Hospitalized older adults with cognitive impairment (CI) have an increased risk for adverse outcomes. Acute Care for Elders (ACE) Units were developed to reduce functional decline in hospitalized older adults. INTERVENTION: We developed a quality improvement (QI) initiative to disseminate ACE care processes to non-ACE units, converting them into "Virtual ACE" units. The aim of this evaluation is to examine the impact of this intervention on the mobilization of patients with CI. POPULATION: Older adults with CI admitted to a study unit (ACE Unit or seven Virtual ACE units). METHODS: We conducted a pre/post-intervention evaluation of the proportion of …

The Relationship Between Caffeine Consumption And Sleep Quality Of Students Of The Faculty Of Sports Science Universitas Negeri Malang, Windi Chusniah Rachmawati, Dian Mawarni, Lucky Radita Alma, Adiska Rahma

Preventia: The Indonesian Journal of Public Health

Coffee is a popular drink consumed in Indonesia, especially among people aged 17 until 25 years. Coffee contains thousands of natural chemicals, one of which is caffeine, which has negative impacts on health if consumed in excessive amounts. The purpose of this study is to describe the caffeine-based beverages consumed and sleep quality and to assess the association between caffeine use and sleep quality. This study used a cross-sectional design with 120 respondents who completed a questionnaire about the history of caffeine-based beverage consumption and PSQI sleep quality, PSQI is used to measure the state of sleep which consists of …

Effects Of Stressor Exposure And Locus Coeruleus Opioid Signaling On Coping And Anxiety-Like Behavior In Rats, John Arthur Tkaczynski

Theses and Dissertations

Stress is a physiological state of altered neuroendocrine signaling and heightened indices of behavioral vigilance and arousal in response to threatening stimuli. This project aimed to investigate the adaptations to stress that occur in the noradrenergic locus coeruleus (LC) and how these changes affect stress coping behavior. We began by investigating how adolescent restraint and predator odor stress affects coping when presented with a secondary noxious stimulus in the defensive shock probe burying task one week following stressor exposure, finding that stressed male rats demonstrate a more active coping response and stressed female rats demonstrate a more passive coping response, …

Cddo-Me Attenuates Fibroblast And Macrophage Activation In Limited Cutaneous Systemic Sclerosis, Heetaek Yang, Emily A. Morris, Chen-Yu Wang, Nicole M. Orzechowski, Michael Whitfield, Patricia Pioli

Dartmouth College Master’s Theses

Abstract

Systemic Sclerosis (SSc) is a rare autoimmune disease characterized by multiple-organ involvement and notably by fibrosis. Current therapies for SSc focus on symptom managements and treating specific organ related complications. However, heterogeneous nature of the disease further complicates treatment responses and hinders the development of new therapies. Therefore, there is a critical unmet need for the development of patient-specific therapeutics.

The objectives of this thesis were: (1) to evaluate the therapeutic potential of Bardoxolone Methyl (CDDO-Me) in both SSc fibroblasts and SSc macrophages. To achieve these goals, I utilized both wet-lab analysis tools and computational analysis.

As part of …

Scoring System For Screening Fitness To Work For Offshore And Onshore Remote Area Worker, Kasyunnil Kamal

Occupational and Environmental Medicine Journal of Indonesia

Background: About 10-15% of medical examinations of workers at upstream oil and gas companies are not conducted properly. In some cases, workers die at worksites. Many doctors carrying out the assessment lack the competency to assess occupational risks. In this study, we developed a scoring system for ‘fitness for work’ assessment, which can be used by trained doctors.

Methods: Diagnostic testing was done with comparing the results of the determination screening fitness for work using a scoring system with the determine fitness for work results by Occupational Medicine Specialist as a gold standard in the same group. The entire 607 …

Impact Of Delivery Mode On Neonatal Serum Bilirubin Levels And Jaundice Risk In Melati Husada Women And Children Hospital, Malang, Andreas Budi Wijaya, Harjoedi Adji Tjahjono

Preventia: The Indonesian Journal of Public Health

It is anticipated that between 60 and 80 percent of healthy, full-term newborns would exhibit idiopathic neonatal jaundice. Mode of delivery has recently been associated with idiopathic neonatal jaundice. As seen at Melati Husada Women and Children Hospital in Malang, the increasing number of caesarean section was followed by increased frequency of neonatal hyperbilirubinemia. This hyperbilirubinemia should be resolved within two weeks, therefore, prolonged jaundice should be deeply investigated. This research aimed to investigate the relationship between mode of delivery and neonatal serum bilirubin at 48 hours after birth at Melati Husada Women and Children Hospital in Malang. During observational …

The Effect Of Blue Light Filter Lens Glasses On The Occurrence Of Asthenopia Symptoms In Visual Display Terminal Users, Arif Hening Mustikaningrum, Dewi Sumaryani Soemarko, Indah Suci Widyahening

Occupational and Environmental Medicine Journal of Indonesia

The widespread use of Visual Display Terminals (VDTs) is associated with visual and musculoskeletal complaints, particularly Asthenopia, which may reduce productivity. A 32-year-old female financial worker presented with eye discomfort, including sore eyes, blurred vision, dizziness, and twitching on her left temple, particularly during extended computer use. The symptoms were relieved with rest. Most VDTs now use Light Emitting Diodes, which emit more blue light than LCDs and may cause eye fatigue and disrupt sleep. Currently, blue light filter lenses are available in the market, however, further study of existing scientific publications is necessary to ensure the effectiveness of blue …

Efektivitas Massage Endorphin Untuk Mengurangi Kecemasan Pada Ibu Hamil Menjelang Persalinan, Widiya Saryani, Dini Nur Alpiah

Jurnal Fisioterapi Terapan Indonesia

Pregnancy is a biological process involving complex physiological and psychological transitions that demand high adaptability from women, especially approaching childbirth. Anxiety during the third trimester is frequently reported and is associated with increased cortisol secretion, which may negatively impact labor effectiveness. This literature review aimed to synthesize scientific evidence regarding the effectiveness of endorphin massage in reducing anxiety among pregnant women in the third trimester. The review used a systematic approach based on the PICO framework, covering studies published between 2021 and 2025. Databases such as PubMed, Google Scholar, and SINTA were used to identify quasi-experimental studies comparing endorphin massage …

Efektivitas Latihan Aerobik Dalam Mengurangi Gejala Depresi: Literature Review, Putra Adytio Giriyoga, Dini Nur Alpiah

Jurnal Fisioterapi Terapan Indonesia

Depression is one of the most common mental health disorders worldwide and can significantly affect an individual's quality of life. Various treatment approaches have been implemented, with one of the most noteworthy being non-pharmacological interventions in the form of aerobic exercise. This study aims to review the effectiveness of aerobic exercise in reducing depressive symptoms. This research is a narrative literature review, in which 3,610 articles were initially identified and then filtered based on inclusion-exclusion criteria, resulting in 8 articles. After eliminating duplicates, further screening was conducted through critical appraisal. The final selection of 8 articles was reviewed. The findings …

Intouch Week Of June 30, 2025, New York Medical College

InTouch

• Annual Golf Tournament Brings Friends and Supporters to the Green
• The Academy of Medical Educators Wraps Up Successful First Year
• SOM Preceptors Recognized for Their Invaluable Role for Medical Students
• NYMC Alpha Omega Alpha Chapter Receives Grant to Combat Food Insecurity
• New Telehealth Partner for Student Mental Health Services
• Stay Safe and Connected with the NYMC 4U App
• Cellular Receptor GPR75 Linked to the Progression of Liver Disease
• BSB Gets a Bold New Look
• Alumni Spotlight: The Path to Connection