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Evaluation Of Zap-70 Inhibition In The Prevention Of Leukemia Cell Migration Into The Central Nervous System (Cns), Mark Westbroek

Graduate Medical Education Research Journal

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A Case Of Post-Transplant Lymphoproliferative Disorder 10 Years After Renal Transplantation, Carlos Izarra Boscan

Graduate Medical Education Research Journal

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Nevus Lipomatosus Superficialis: A Rare Benign Skin Lesion – A Case Report, Adeyinka Aladejare

Graduate Medical Education Research Journal

NA

Facilitating Living Kidney Donation: Retrospective Evaluation Of Weight Loss Interventions To Support Kidney Donation, Julia Dumitrescu, Roslyn Mannon, Scott Westphal, Ashley Brabec, Regina Rau, Amy Olsen, Taylor Cidlik

Graduate Medical Education Research Journal

Background. Living kidney donor transplantation provides recipients with kidney failure with an excellent graft function and survival. Donation of a kidney entails a thorough medical and psychosocial evaluation. Obesity is an increasingly prevalent medical condition and a known risk factor for the development of chronic kidney disease post-donation. Accepting overweight and obese individuals as living kidney donors remains controversial. The purpose of this study was to review the impact of obesity on the determination of candidates for living kidney donation at a single transplant center.

Methods. We performed a retrospective chart review of living kidney donors evaluated over 5 …

Exercise-Induced Gene Expression Profiles In Adults With Obesity: A Systematic Review Of Molecular Adaptation, Brandon Galvan, Luis Alberto Flores, Flor Isela Torres-Rojo, Natanael Cervantes-Hernández, Cinthia Verónica Villegas-Balderrama, Liliana Aracely Enríquez-Del-Castillo

Baltic Journal of Health and Physical Activity

Background: Obesity is a multifactorial and chronic condition characterized by excess adiposity and systemic low-grade inflammation. Exercise exerts metabolic and anti-inflammatory effects partly mediated through gene expression modulation in skeletal muscle and adipose tissue. However, heterogeneous responses among obese individuals suggest that genetic and epigenetic mechanisms shape exercise adaptation. Objective: This systematic review aimed to identify the genes and molecular pathways modulated by physical exercise in adults with obesity, and to classify them according to their biological functions across different exercise modalities. Methods: Following PRISMA guidelines, randomized controlled trials were searched in PubMed, SpringerLink, Science Direct, Cochrane, LILACS, Web of …

A Case Report Of Mesalazine-Induced Pulmonary Injury In A Patient With Ulcerative Colitis, Vasileios Paraschou, Vasileios Papavasileiou, Ilektra Voulgareli, Vasilios Tzilas

HCA Healthcare Journal of Medicine

Introduction

Mesalazine (5-aminosalicylic acid) is widely used as a first-line therapy for ulcerative colitis (UC) due to its efficacy and safety profile. Rarely, it can cause pulmonary toxicity with variable clinical and radiologic manifestations, making diagnosis challenging.

Case Presentation

We report the case of a 52-year-old woman with UC who developed persistent fever and progressive exertional dyspnea following escalation of mesalazine dosage. Imaging revealed diffuse bilateral ground-glass opacities, while infectious and UC-related pulmonary causes were excluded. Pulmonary function testing demonstrated restriction and markedly reduced diffusing capacity. Following mesalazine discontinuation and initiation of corticosteroid therapy, the patient experienced rapid symptomatic, functional, …

Can Gingival Crevicular Fluid Help In Diagnosing Pulp Inflammation? A Systematic Review, Wael Kassamany, Roula Abiad

BAU Journal - Science and Technology

This review aims to find if there’s a positive correlation between biological markers detected in human gingival crevicular fluid and pulp inflammation.

An electronic search of three databases; PubMed, EBSCOhost and Google Scholar was conducted using the keywords “tooth or teeth or pulp” AND “gingival crevice fluid or gingival crevicular fluid” for English articles published between the year 1990 and 2026. Information regarding study design, patients age range and gender distribution, sampling method used, types of biomarkers studied, assay test used, and key findings of each article were extracted and analyzed.

Biomarkers studied were substance P “SP”, neurokinin A “NKA”, …

Analisis Biaya Standar Pelayanan Minimal (Spm) Kesehatan Menggunakan Aplikasi Siscobikes Di Tingkat Kabupaten/Kota Di Indonesia, Purwa K. Sucahya, Resi Natalia Turnip, Lemi Kurniawan, Bondan Wicaksono Adhi, Iwan Supriyadi, Ni’Matun Nurlaela

Jurnal Ekonomi Kesehatan Indonesia

This research investigates the capacity of the Siscobikes (Health Costing System) application to forecast the financial requirements for the execution of Minimum Service Standards (SPM) within Indonesia’s health sector at the district and city levels.. The study utilized cross-sectional data from 166 districts/cities to ascertain the projected health financing requirements and juxtaposed these estimates with the actual budgetary allocations. The results show that each district/city requires approximately IDR 16 billion annually for SPM. Districts require around IDR 17 billion annually, while cities require approximately IDR 13 billion. Substantial regional disparities are observed: Eastern Indonesia has the highest per capita needs …

Profil Biomarker Apolipoprotein B Dan Lipid Terhadap Skor Syntax Pada Pasien Sindrom Koroner Kronik, Muhammad Novran Chalik, Erwin Sukandi, Taufik Indrajaya, Ferry Usnizar, Syamsu Indra, Imran Saleh, Rukiah Chodilawati, Irfannuddin Irfannuddin

Jurnal Penyakit Dalam Indonesia

Introduction. Apolipoproteins are structural components of plasma lipoproteins that are involved in lipoprotein metabolism and lipid transport, reflecting the number of circulating atherogenic particles. The degree of coronary artery stenosis can be assessed by calculating the Synergy between PCI with TAXUS/paclitaxel-eluting stent and Cardiac Surgery (SYNTAX) score, which is an angiographic scoring system used to evaluate the complexity of coronary artery lesions. This study aimed to investigate the profile of apolipoprotein B and lipids, as well as their correlation with the SYNTAX score in patients with chronic coronary syndrome.

Methods. An observational analytic study with a cross-sectional design …

Evaluation Of Il-17/Il-23 Axis In Iraqi Patients With Essential Hypertension, Fatima Jalal Ayez, Manal Mohammed Kadhim

Al-Qadisiyah Medical Journal

Background: Essential hypertension is a multifactorial disorder and a major global public health concern. Emerging evidence suggests that chronic low-grade inflammation plays a key role in its pathogenesis. The interleukin-17/interleukin-23 (IL-17/IL-23) axis has been identified as a critical inflammatory pathway linking immune activation to vascular dysfunction and elevated blood pressure. Aim of study: Evaluate the IL-17/IL-23 axis including the levels of IL-17A and IL-23 in patients with essential hypertension and to investigate their potential role as inflammatory biomarkers. Patients, Materials and Methods: A case-control study was conducted in Al-Diwaniyah Governorate, Iraq, from October 2025 to February 2026. The study …

Cracking The Code Of Resistance: Carbapenem-Resistant Urinary Tract Infections In Public And Private Hospitals, Shaista Bakhat, Fakhur Uddin, Muhammad Sohail, Shehla M. Baqai, Naresh Kumar, Saman Nadeem

Folia Medica Indonesiana

This research aimed to analogize the resistance patterns against carbapenem antibiotics in Enterobacterales uropathogens between two healthcare facilities. The authors performed this study at the Basic Medical Sciences Institute, Jinnah Postgraduate Medical Center, and the National Medical Center. A total of 374 UTI patients were enrolled, equally distributed in the two centers (187 each hospital). Molecular assays supplemented phenotypic susceptibility testing to detect carbapenem resistance. Statistical analysis, including multivariate logistic regression, was performed to identify associations between hospital type and carbapenem resistance. Of 374 urine samples, CA-UTIs were found in 86 (23.1%) and 90 (24%), while HA-UTIs occurred in 101 …

The Effects Of Kombucha Consumption On Obesity And Diabetes Outcomes, Linda Linda, Lina Lukitasari, Rahmad Darmawan, Citrawati Dyah Kencono Wungu, Roikhatul Khusniyah, Ervi Audina Munthe

Folia Medica Indonesiana

Numerous clinical trials have explored the potential of kombucha in addressing obesity and diabetes. Nonetheless, a thorough and integrated analysis of findings from these trials remains lacking. Hence, this review seeks to assess effects of kombucha on metabolic parameters and examine the reliability and quality of available clinical evidence to support its role as a dietary intervention. Studies were sourced from scientific databases: PubMed, Scopus, and Web of Science. This review included studies that reported outcomes related to obesity and diabetes in individuals with either condition who received kombucha as an intervention. There were six clinical trials included. A total …

Extracellular Vesicles In Adult Acute Myeloid Leukemia, Haniatul Qomariya, Fitrotin Azizah, Yetti Hernaningsih

Folia Medica Indonesiana

Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy marked by uncontrolled expansion of immature myeloid cells and disruption of normal hematopoiesis. Beyond genetic abnormalities, accumulating evidence demonstrates that leukemic progression is strongly shaped by intercellular communication within the bone marrow niche. Extracellular vesicles (EVs), including exosomes and microvesicles, have emerged as key mediators of this communication, transporting bioactive molecules that influence leukemic cell behavior, immune responses, and treatment sensitivity. This systematic review synthesizes current findings on EVs in adult AML, focusing on their biogenesis, molecular cargo, roles in disease pathogenesis, diagnostic and prognostic relevance, and therapeutic potential. Following PRISMA …

The Inflammatory Link Between Obesity, Quality Of Life, And Female Sexual Dysfunction: The Role Of Interleukin-6, Amelia Putri Ariyani, Lilik Herawati, Zidni Imanurrohmah Lubis, Alifia Syafira Putri, Adhiratih Ken Sari

Folia Medica Indonesiana

Female sexual dysfunction (FSD) is a common condition that impairs women's quality of life and is frequently associated with obesity. Beyond hormonal and vascular mechanisms, chronic low-grade inflammation, particularly elevated interleukin-6 (IL-6), has been proposed as a biological mediator of this association. This systematic review, registered in PROSPERO (CRD420251046082), aimed to evaluate the role of IL-6 in mediating the association between obesity and FSD. A comprehensive search of PubMed, Scopus, Embase, and Web of Science was conducted for studies published between 2018 and 2025, focusing on obese women, quantitative IL-6 measurements, and validated assessments of sexual function such as the …

Exploring The Role Of Circulating Mir-21 As A Potential Biomarker For Celiac Disease In Pediatric Patients, Shaymaa M. Jabbar, Manal M. Khadhim

Al-Qadisiyah Medical Journal

Background: This training explored the possibility of circulating miR-21 as a biomarker for celiac illness (CD) in pediatric patients. The demographic and clinical characteristics were compared between groups. A case-control design was employed with 45 pediatric CD patients and 45 healthy controls. Aim: The present training stayed directed to exploring the expression of circulating miRNAs in those sick with celiac disease—three miRNAs—miR-21-3p. Methods: Blood samples were collected from participants, and RNA was isolated. miR-21 expression was quantified using STEM-LOOP RT-qPCR. Demographic data (age, gender, residence) and clinical features (family history, disease duration, symptoms) were collected. Serological tests for CD diagnosis …

Interaction Between Tnf Inhibitors And Serum Il21levels With Susceptibility To Rheumatoid Arthritis, Maryam Yaseen Shaker, Orass Madhi Shaheed

Al-Qadisiyah Medical Journal

Background: Objectives: To estimate the significance of the central role of the immunological marker IL-21 level and know the interaction between TNF inhibitors and IL-21 with susceptibility to rheumatoid arthritis (RA) sickness. Material and Methods: Serum testers were obtained from three distinct categories: the initial group consisted of those sick and diagnosed with RA who were undergoing treatment with TNF inhibitors, the second group included individuals who were recently diagnosed with RA, and the third group comprised healthy volunteers. The serum from this sample was utilized for quantifying the levels of IL-21 using the ELISA technique. Result: The level of …

Association Between Cooking Fuel Type And The Incidence Of Acute Respiratory Infections In Toddlers In Indonesia: A Cross-Sectional Study Based On 2017 Sdki Data, Ghina Puspa, Meiravigliosi Hermawan, Nuha Rafida Yumna

Jurnal Nasional Kesehatan Lingkungan Global

Acute Respiratory Tract Infection (ARI) remains a major health problem among toddlers in Indonesia and is closely related to exposure to indoor air pollution. This study aims to analyze the relationship between the type of cooking fuel used by households and the incidence of ARI in toddlers in Indonesia. The study used a cross-sectional design based on data from the 2017 Indonesian Demographic and Health Survey. The study sample included 196,804 respondents who met the inclusion criteria, namely having complete information on the type of cooking fuel and ARI symptoms. The independent variable was the type of cooking fuel divided …

Detection And Evaluation Of Biofilm-Producing Clinical Bacterial Isolates By Tcp Method In Karbala-Iraq, Huda Ali Salman Almosawey

Al-Esraa University College Journal for Medical Sciences

Background: A biofilm is a complicated, three-dimensional microbial community that forms at an interface and interacts with its surroundings. To detect the ability of bacteria to form biofilms, the Tissue Culture Plate Method (TCP) is one of the most widely accurate methods and is frequently used with clinical isolates. Objective: This study aims to determine the ability of clinical bacterial isolates to form biofilms using the TCP method and to compare biofilm production between different types of bacteria; to study the relationship between biofilm formation and antibiotic resistance, which helps in understanding the reasons for the failure of some antibiotic …

Epigenetic Regulation Of Immune Responses In Autoimmune Diseases And Cancer: Mechanisms And Therapeutic Implications, Faisal H. Al-Amier, Ammar B. Al-Asadi, Aljuboori M. Nafea, Karar M. Jaleel

Al-Esraa University College Journal for Medical Sciences

Immune tolerance balances immune responses with self-tolerance, a balance that is directive by epigenetic pathways. These mechanisms responsible for gene expression regulation and immune cell activity, and include DNA methylation, histone modifications, and non-coding RNAs. Disruption of mechanisms involved in the autoimmune disorder pathophysiology like systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis through the induction of long term inflammation and breakdown of immune tolerance. In cancer, epigenetic changes allow immune evasion and establish an immunosuppressive tumor microenvironment. Epigenetic markers have been used for diagnosis and prognosis, and epigenetic treatments have the potential to rebalance the immune system and improve …

Cleft Lip And Palate: From Genetic Foundations To Psychological Impact – A Multidisciplinary Review, Farah Abdulwahab Al-Saadi, Teeba Fares Hadi, Sura Saleem Albermani

Al-Esraa University College Journal for Medical Sciences

Cleft lip and/or cleft palate consider one of the most known and common congenital disorders of the head causing clear disruption of the normal face structure. Despite being the most seen birth defects, the clefts genetic basis is still not fully comprehended. Clefts have sporadic genetic nature, it can occur duo to rare mutations as part of syndromic disease or it can be isolated, non-syndromic cleft. The contemporary advances in genomic technology have enabled a deeper comprehension of the complex architecture of cleft lip/palate, of these technologies are genome-wide association studies, whole genome sequencing, transcriptome-wide association studies and others. Furthermore, …

Global Trends And Research Landscape Of Metformin And Artificial Intelligence: Bibliometric Analysis, Raya Doraid Mohammed, Alaa Qasim Hayder, Hamza A. Saadallah, Ali Q Saeed, Alice Louis Yousif, Safa M Salim, Noor Mahmood Sultan, Mohammed Ahb. Al-Krdoshi

Al-Esraa University College Journal for Medical Sciences

This bibliometric study examines global research trends and key thematic areas in Artificial Intelligence (AI) applications related to Metformin, especially in diabetes treatment. A total of 227 articles were retrieved from the Science Citation Index Expanded (Web of Science Core Collection) from 2020 to 2024. VOSviewer and CiteSpace were used to analyze publications by year, country, institution, journal, citation impact, and keyword co-occurrence. The United States, Canada, and South Korea contributed over 85% of the output, with leading institutions including the University of California, Los Angeles. Keyword mapping identified ``machine learning,'' ``Metformin,'' and ``Type 2 Diabetes'' as the most influential …

Measure The Sensitivity Of Streptococcus Mutans Against Cds Nanoparticles, Ali Essam Ali, Sara Habeeb Jassim, Abeer Ali Marhoon

Al-Esraa University College Journal for Medical Sciences

Dental caries is the most common disease that poses a threat to human health. As a result, caries prevention is crucial because it is now a major global public health issue. Nowadays, there is more focus on employing nanoscale medication delivery devices to prevent dental cavities. Here, an antibacterial activity of CDs synthesis with allover plant by measuring the turbidity and bacterial colony after the effect of CDs NPs on the one-off gram-positive bacteria streptococcus mutans that cause dental caries. The results showed significant (p < 0.05) concentration of 10, 15, 25 μ g/mL of CDs NPs. Fourier transmission infrared spectroscopy (FT-IR) analysis showed the effect of CDs NPs on the bacterial cell, scanning electron microscopy (SEM) that showed the size, shape and the attachment of Nanoparticles to the bacterial cell wall that support the effect of nanoparticles on bacteria. When compared to chemical and physical procedures, environmentally friendly technologies can produce simple, easy, and affordable nanoparticles. has the capacity to function as antimicrobial agents.

Clinical Interactions Of Celiac Disease And Relationship With Type 1 And Type 2 Diabetes Mellitus, Noor Thair Tahir, Raghda Shams Akram, Aseel Ibrahim Abbas, Sahar Abdul Wahab Alshaban, Fatma Abd Alhamza Obed

Al-Esraa University College Journal for Medical Sciences

Celiac disease is a typical autoimmune ailment that can be brought on by gluten, a protein present in wheat, barley, and rye. It is estimated that one person out of every 100 worldwide has celiac disease, with the majority going untreated. Although it can manifest asymptomatically, celiac disease is typified by a variety of gastrointestinal and extra-intestinal symptoms. The consistency of clinical, serological, and histopathological data is essential for the diagnosis of celiac disease. The diagnosis, nevertheless, is often missed and can be difficult. A higher risk of complications and a negative impact on quality of life are linked to …

Mpox Preparedness And Pandemic Memory: An Exploratory Study Among Young And Highly Educated Populations In Iraq, Israa M. Ali Alameen

Al-Esraa University College Journal for Medical Sciences

No abstract provided.

The Role Of Nanotechnology In Improving The Physical And Mechanical Properties Of Denture Base Material, Rasha Mehdi, Intisar J. Ismail, Ahmed Ali Mohammed

Al-Esraa University College Journal for Medical Sciences

Background: Polymethyl methacrylate (PMMA) is still the most common material used for denture bases but its mechanical and physical properties. The aim of this systematic review was to assess the application of nanotechnology for enhancing physical and mechanical properties of denture base materials. Methods: A systematic search of PubMed/MEDLINE, Scopus, and Web of Science was performed to identify in vitro experimental studies from 2020 through 2025. The review was conducted according to the PRISMA 2020 statement. Included studies that characterised the mechanical or physical properties of nanoparticle-reinforced denture base materials. Results: Fourteen in vitro experimental studies were eligible for the …

Prevalence And Determinants Of Metabolic Syndrome Among Adults Attending Primary Health Care Centers In Baghdad: A Cross-Sectional Study, Muammar Basheer Yasir, Almottesembellah Abdalruhman Gaiz, Noor Abdulredha Jaleel

Al-Esraa University College Journal for Medical Sciences

Metabolic syndrome has emerged as an important health concern globally, especially in developing countries where urbanization and lifestyle changes are rapidly increasing. No reliable epidemiological information regarding the prevalence and risk factors associated with metabolic syndrome is available among Iraqi adults in primary health care (PHC) clinics. This study was designed to determine the prevalence rate of metabolic syndrome and identify potential risk factors among adults attending PHC centers in Baghdad. Methods: An analytical cross-sectional study design was used, targeting 412 adult subjects selected randomly from multiple PHC centers in Baghdad. Sociodemographic, lifestyle, anthropometric, and biochemical data were collected. The …

Determination The Prevalence Of Multidrug Antimicrobial Resistance Of Nosocomial Enterobacter Cloacae Isolates From Clinical Specimens In Baghdad Hospitals, Baidaa Mijbel Ali

Al-Esraa University College Journal for Medical Sciences

Background: Enterobacter cloacae have challenged global health through nosocomial infections, especially among immunocompromised patients. In the most overburdened healthcare systems, more study and strategy are anticipated. Aim of the study: To determine the prevalence of Enterobacter cloacae in hospital-acquired infections in Baghdad hospitals and to evaluate its antimicrobial resistance patterns across burn, wound, and urine samples, with a focus on multidrug resistance and antibiotic resistance trends. Methods: Three hundred and seventy-seven patient samples were collected and examined at a teaching laboratory in Baghdad between January 2024 and December 2024. These had 513 samples, 238 burn swabs, 139 wound swabs, and …

The Association Between Osteoporosis In Females Following Menopause And Vitamin D Deficiency, Hadel Kareem Al-Rubaiawi, Noor Adel Hussein, Dunia Abdul Jabbar Star, Amer Hasan Abdullah, Salma Abdul-Ridha Abbas, Hawazin Aziz Hamim

Al-Esraa University College Journal for Medical Sciences

The intricate relationship among osteoporosis, vitamin D deficiency, and hormonal changes. Growth hormone, cortisol, parathyroid hormone, estrogen, testosterone, thyroid hormones, and thyroid hormones are a few of the hormones that affect bone turnover and density. Alterations in their concentrations, whether brought on by healthy aging or illnesses, can interfere with bone remodelling and increase the risk of osteoporosis. Moreover, inadequate levels of vitamin D increase the risk by decreasing the absorption of calcium and the mineralization of bone. Estrogen and vitamin D deficits increase bone loss, especially in postmenopausal women. Proactive treatment techniques, including hormone replacement therapy, vitamin D supplements, …

Reinforcement Of Maxillofacial Silicone, Taqwa Majid Abdulhussein, Thekra Ismael Hamad

Al-Esraa University College Journal for Medical Sciences

Maxillofacial prostheses are very important for helping people with head and neck defects (caused by congenital disabilities, accidents, or cancer treatments) get better. Their goal is to restore oral function, comfort, appearance, and mental health. Since the 1960s, silicone elastomers, especially polydimethylsiloxane, have been considered the best materials because they are highly resistant to tearing and stretching, biocompatible, and naturally colour-stable, but silicone has a very short clinical lifespan because it breaks down when exposed to UV radiation, moisture, biological fluids, and mechanical stress. The main goal of reinforcement is to add fillers to silicone elastomers to strengthen and improve …

Organic Coumarin Derivatives As Laser-Active Materials: A Review Of Synthesis, Optical Behaviour, And Applications, Aya H. Mohammed, Mohammed Hasan Al-Dahlaki

Al-Esraa University College Journal for Medical Sciences

Coumarin derivatives have settled into a position of unusual prominence among organic laser-active materials. Few other chromophore families combine such favourable photophysics with synthetic chemistry that is at once long-established and still actively evolving. The aim of this review is to draw together what is now known about coumarin-based laser dyes — their preparation, their optical behaviour, the laser performance that has been achieved with them, and the broader applications that have followed — with particular attention to work published between 2019 and 2026. Considerable space is given to the structural origin of the strong intramolecular charge transfer (ICT) character …