Digital Commons Network^™

Claudins Interact With Lilrb Immune Inhibitory Receptors To Promote Myeloid Immunosuppression In Cancer, Xiaoye Liu, Ryan Huang, Zhiqiang Ku, Jingjing Xie, Heyu Chen, Yubo He, Qi Lou, Chengcheng Zhang, Xing Yang, Cheryl Lewis, Jade Homsi, Ankit Gupta, Lei Dong, Kenian Chen, Annabel Tu, Liming Du, Hailong Yu, Qing Hu, Meng Fang, Bufan Li, A E M Adan Khan, Caroline Simith, Samuel John, Lin Xu, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang

The Brown Foundation: Institute of Molecular Medicine

The mechanisms underlying tumor cell-myeloid cell interactions in the tumor microenvironment (TME) remain unclear, and predictive biomarkers for patient response to myeloid checkpoint blockade are lacking. This study identified specific binding between tight junction claudins (CLDNs) and leukocyte immunoglobulin-like receptor subfamily B2 (LILRB2) and LILRB5. In multiple human cancer cohorts, the spatial proximity of LILRB2-positive macrophages to CLDN-expressing cancer cells correlated with clinical outcomes, highlighting this spatial relationship as a potential biomarker. In syngeneic LILRB2-transgenic and humanized mouse models, CLDN18.2-LILRB2 interactions triggered bidirectional signaling, enhanced the immunosuppressive activity of myeloid cells, and accelerated tumor progression. These effects were reversed by …

Six-Week Time-Restricted Eating Lowers Premature Mortality Risk In Overweight Early Elderly Adults: Evidence From A Body Shape Index, Przemysław Domaszewski, Mariusz Konieczny

Baltic Journal of Health and Physical Activity

Background: A Body Shape Index (ABSI) is an anthropometric indicator combining waist circumference, weight, and height, providing a BMI-independent measure of central obesity and a recognized predictor of mortality. Despite its relevance, research on ABSI in early elderly populations remains limited. This study assessed the impact of a six-week time-restricted eating (TRE) intervention on ABSI z-scores in overweight adults aged 65–74, with attention to gender differences. Materials and Methods: A total of 116 participants were randomized into a TRE group (16:8 fasting window from 8:00 PM to 12:00 PM) or a control group maintaining habitual eating. ABSI z-scores were evaluated …

Chrononutrition: A Beginner’S Guide For Mental Health Professionals, Jerrod Brown Phd, Ma, Ms, Ms, Ms, Ms, Ms, Jeremiah Schimp Phd, Ma, Lpcc, Leanne Skehan Dcn, Msacn, Mph, Mba, Shelley Mydra Dmft, Lmft, Jonathan Ward Dc, Phd(C), Ms, Dibcn, Kelly Rain Collin Ed.M.

Nutritional Neurocriminology Today

Chrononutrition focuses on how nutritional timing influences biological rhythms (Castro-Mata et al., 2025; Kim et al., 2025; Raji et al., 2024). This includes examining how dietary patterns (e.g., timing, frequency, and regularity) affect the circadian system and metabolic health (Cart & Pauling, 2025; Juliana et al., 2023; Negri et al., 2025). Sleep schedule, shift work, substance use, malnutrition, and other external factors, which will be discussed in this article, can disrupt the circadian rhythm. This disruption increases the risk for serious mental health problems (Baron & Reid, 2014; Castro-Mata et al., 2025; Franzago et al., 2023). Alternatively, consistent and nutritious …

Drd2 Rs6276 Polymorphism And Trait Impulsivity In Individuals With Mixed Behavioral And Substance Addictions, Gabriela Zdunek, Remigiusz Recław, Aleksandra Suchanecka, Krzysztof Chmielowiec, Dariusz Larysz, Patryk Ilków, Kinga Łosińska, Jolanta Chmielowiec, Łukasz Jaworski, Anna Grzywacz

Baltic Journal of Health and Physical Activity

Background/Objectives: Impulsivity is a key transdiagnostic trait linked to dysregulated reward processing in both behavioral and substance-related addictions, as recognized in DSM-5. Dopaminergic genes, including DRD2, may modulate individual differences in impulsivity, particularly under conditions of increased addiction vulnerability. This study examined whether the DRD2 Exon 8 rs6276 polymorphism predicts impulsivity levels in men with mixed addictive behaviors compared with healthy controls. Methods: A total of 328 males (128 with mixed behavioral and substance addictions and 200 controls) were assessed. Diagnoses were confirmed using the MINI interview, and impulsivity was measured with the Barratt Impulsiveness Scale (BIS-11). Genotyping of …

Mental Health Under Pressure: A Scoping Review Of Suicide In The Dental Workforce, Man Hung, Spencer John, Nicholas Beasley, Amir Mohajeri, Connor Schwartz, Martin S. Lipsky

Institute on Aging Publications

Aims:

Suicide among healthcare professionals is a growing concern. Despite evidence of high psychological distress in dental practice, suicide in dentists remains underexplored. This scoping review systematically examined the literature on suicide and suicidal ideation among dentists, including prevalence, risk factors, and temporal trends.

Methods:

Searches of PubMed, Scopus, Web of Science, and Dentistry and Oral Sciences Source identified English-language studies reporting suicide, suicidal ideation, or related mental-health risks in dental professionals. Duplicates were removed; titles/abstracts and full texts were screened against predefined criteria. Data were extracted and thematically analysed.Results Fourteen studies met the inclusion criteria and were mostly retrospective …

Pacific Rxtracts - April 2026, Pacific Rxtracts

Pacific RxTracts

Articles:

• LAMA‑LABA Inhalers in COPD
• Another Potential Indication for Dupilumab: Chronic Spontaneous Urticaria
• Clinical Pharmacist‑Led Tobacco Treatment and Contingency Management in Patients With HIV
• FDA Approves First TYK2 Inhibitor for Adults With Active Psoriatic Arthritis
• Oral PCSK9 Inhibition with Enlicitide: A New Frontier in Lipid‑Lowering Therapy
• Lerodalcibep‑liga, Novel PCSK9 Inhibitor for the Management of Hypercholesterolemia
• Pharmaceutical Grade Cannabidiol for Myocardial Recovery in Acute Myocarditis
• Berberine Shows Limited Impact on Visceral and Liver Fat in MASLD Trial
• Comparative Outcomes of Orforglipron and Oral Semaglutide in Adults with Type 2 Diabetes
• Battling Pediatric Episodic Migraines – FDA Expands Approval of Fremanezumab
• Navepegritide …

The Effect Of Cerebral Somatosensory Network Priming On Language Function In Chronic L-Mca Ischemic Stroke: A Companion Case Study, Mandelin E. Wollesen

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Chronic aphasia following a left middle cerebral artery (L-MCA) stroke is often associated with limited recovery beyond the acute phase, necessitating interventions that target neuroplastic mechanisms. This study examined the effects of somatosensory pneumotactile stimulation paired with cognitive-linguistic tasks on functional language performance in an individual with chronic aphasia. Using a single-subject pre-post design, the participant completed a 10-week intervention protocol involving repeated pneumotactile stimulation via the GALILEO system combined with language and motor tasks. Outcomes were assessed using standardized measures, discourse-based language samples, oral reading, repetition, and phonemic verbal fluency. Discourse was analyzed using Correct Information Units (CIUs), words …

Lived Experiences Of Shingles Vaccine-Hesitant Adults Over Age 50 In Riverside County, California, Michelle Beatrice Loomis

Walden Dissertations and Doctoral Studies

Shingles (herpes zoster) causes substantial morbidity, especially among adults over age 50 in the United States. There is a need to better understand the reasons behind low vaccination rates among adults over age 50 given the associated risks for infection and adverse health outcomes that can reduce their quality of life. This qualitative interpretative phenomenological study explored how individuals’ perceptions of the benefits, barriers, susceptibility, and severity of shingles influence vaccine intentions and identified what factors influence vaccine uptake. The health belief model was used to guide the study. Data were collected from one-on-one semistructured virtual interviews with eight adults …

Evaluating The Relationship Between Vitamin D Supplementation, Lifestyle, Social Determinants Of Health, Asthma, And Respiratory Tract Infections, Yun O'Donnell

Walden Dissertations and Doctoral Studies

Hypovitaminosis D is a significant public health concern in the United States associated with inadequate sunlight exposure and insufficient dietary intake. Asthma is a chronic respiratory condition that progressively worsens over time. While asthma is typically managed through individual-level treatment approaches, population-level strategies such as vitamin D supplementation and food fortification policies have not been implemented. A five-tier Public Health Impact Pyramid theoretical foundation guided this nonexperimental quantitative cross-sectional study. Data from 2013-2014 and 2017-2018 NHANES (n = 1,456) was evaluated for relationships between vitamin D supplementation, duration of sunlight exposure, and food security index, with asthma, asthma exacerbation severity, …

The History Of Women In Neuroradiology In North America From 1990 To The Present, Vijay M. Rao

Department of Radiology Faculty Papers

From 1990 to 2024, women neuroradiologists in North America have made tremendous progress in the areas of leadership, clinical innovation, research, education, diversity, equity and inclusion, and global outreach. This chapter begins with summaries of their key accomplishments in four broad domains, followed by short biographical sketches of numerous luminaries organized by leadership roles and areas of expertise, and ending with conclusions and future directions.

Bdcd: A Comprehensive Brain Disease Cell-Cell Communication Database, Xinyi Liu, Citu Citu, Wendao Liu, Nitesh Enduru, Andi Liu, Chia-Hao Tung, Zhongming Zhao

Faculty, Staff and Student Publications

Dysregulated cell–cell communication (CCC) is increasingly recognized as a driver of brain disease pathology, contributing to neuroinflammation, synaptic dysfunction, and neurodegeneration. Nevertheless, existing resources remain limited in brain specificity, regional coverage, and functional annotation. To address this gap, we develop the Brain Disease Cell-cell communication Database (BDCD), the first comprehensive resource focused on CCC networks across major brain diseases. BDCD integrates 38 manually curated datasets, comprising 8 519 425 single cells from single-cell RNA-seq studies and 140 744 spots from spatial transcriptomic maps, spanning 14 brain regions and 13 canonical cell types covering Alzheimer’s disease, Parkinson’s disease, schizophrenia, bipolar disorder, …

Innovator - Spring 2026

Innovator

06 - Message From the President

08 - Time Machine

12 - News

22 - Gabrielle Kemberling ’12

28 - The Oughton Family

34 - Beyond the Seams

44 - Question & Innovate

46 - Ram Roundup

48 - Which Ram Was the GOAT?

52 - Class Notes

56 - In Memory

58 - Trivia

Innovator - Fall 2025

Innovator

06 - Message From the President

08 - Time Machine

10 - News

24 - Nureed Saeed ‘99

28 - Cell Mates

32 - Robert C. Sergott, MD

36 - Working Smarter

42 - Question & Innovate

44 - Alumni Impact

48 - Leeor Gal ‘19

50 - Class Notes

56 - In Memory

58 - Trivia

Innovator - Fall 2023

Innovator

06 - Get to Know Jefferson's Interim President

08 - Leadership Announcements

10 - Time Machine

14 - The Nexus

22 - Climate Change on Your Block

30 - Humana and Jefferson

34 - Question & Innovate

38 - Caffeinated Creativity

42 - Alumni Impact

46 - Ram RoundUp

50 - Brotherhood's Enduring Legacy

56 - Class Notes

60 - In Memory

62 - Trivia

Himmelfarb Library Liaison Letter - April 2026, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Program Development For Maternal Mental Health During The Transition To Motherhood, Lindsey A. Lindsley, Cassandra Nelson

Spring 2026 OTD Capstone Symposium

The transition to motherhood can be both rewarding and challenging, with many women experiencing increased vulnerability to postpartum depression (PPD). This capstone project focused on developing and implementing a six-week maternal mental health program designed to support postpartum women through education, occupational engagement, and peer connection. Grounded in the Model of Human Occupation (MOHO), the program used a hybrid format combining in-person and virtual sessions to improve accessibility. Program outcomes were evaluated using surveys, the Occupational Self Assessment (OSA), and participant feedback. Participants demonstrated increased knowledge of postpartum mental health, greater confidence in their maternal roles, and improved ability to …

Iris Melanoma: A Case Report And Review, Emily Scully Od, Breyne Middleton Od

Optometric Clinical Practice

Background: Uveal melanoma is the most common primary cancer of the eye. It can be diagnosed with fundus exam and ancillary tests. Metastasis occurs in about half of primary uveal melanoma patients and is very often fatal. The liver is the most common site of metastasis. Iris melanomas are the least common type of uveal melanoma. Choroidal and ciliary body melanoma are the most common. Iris nevi are quite common and the rate of transformation into melanoma is low but early detection is critical given the high mortality rate associated with metastasis.

Case Report: This case highlights the importance of …

Exploring The Impact Of Cat Nutrition On Consumer Purchases: An Examination On Feline Microbiome, Health, And Owner Responses, Cassidy Curry

Honors College Theses

The gastrointestinal (GI) microbiome plays a critical role in feline health, influencing conditions such as inflammatory bowel disease (IBD), kidney disease, and other digestive disorders. Diet is a major factor affecting microbial balance, yet many cat owners lack sufficient knowledge of feline nutrition. This may lead to suboptimal feeding practices that negatively impact microbiome stability. This study aimed to evaluate the relationship between an owner’s nutritional knowledge and their pet food purchasing decisions. Specifically, it examined feeding schedule, food type and consistency, supplement use, and veterinary engagement. A 13- question survey was administered to 84 Murray State University Honors College …

The Significance Of Vaccine Education In Vaccination Status, Emma Webb

Honors College Theses

In recent years, more of the general population of the United States has become skeptical about vaccines and overall vaccination numbers have declined. Since the Covid-19 pandemic, vaccines have become somewhat of a controversial topic due to varying opinions about the adverse reactions and effectiveness of vaccines. The purpose of this study was to determine if there is a correlation between a person’s overall knowledge of vaccinations and a person’s vaccination status by asking a series of questions about the science used in vaccines and identifying the participant’s vaccination status in regards to influenza and Covid-19. This study also asked …

Burnout Sentinel: An Early Warning System For Student Burnout Using Workload And Recovery Indicators, Minh Duy Do

Expo Student Presentations

2026 Spring Expo Video Essay Presentation

• Biological & Life Sciences
• Health Sciences & Health Professions
• Physical & Applied Sciences
• Service-Learning
• Social & Behavioral Sciences

Instrumental Avoidance Promotes Safety Learning Across Distributed Neural Circuits, Zhenfu Wen, Lihan Cui, Muhammad Badarnee, Kai Zhang, Isabel Moallem, Hannah Mcmanus, Zakiya Atiyah, Joseph Borrelli, Wen Li, L Elliot Hong, Peter Kochunov, Mohammed R Milad

Faculty, Staff and Student Publications

Background: Instrumental avoidance is a coping strategy that plays a critical role in anxiety and trauma-related disorders. Yet, the neural mechanisms supporting instrumental avoidance and its interaction with extinction learning remain incompletely understood.

Methods: Fifty-nine healthy adults completed a two-day fMRI paradigm including Pavlovian threat conditioning, avoidance learning, extinction, and memory recall. Subjective reports measuring the 'fear ratings' for each CS were administered and analyzed across all experimental phases. Neural responses were analyzed using univariate general linear modeling and multivariate pattern analysis with a validated threat/safety decoder. To assess generalizability, the analysis pipeline was repeated in an independent cohort (n=59) …

Unpacking Developmental Programming: A Conceptual And Historical Analysis In The Context Of Dohad, Andrea Gretchev, Heide S. Temples, Gillian England-Mason, Deborah Dewey, Sara M. Sarasua, Christopher Farrell, Vivian Haley-Zitlin

Publications

The Developmental Origins of Health and Disease (DOHaD) paradigm posits that early environmental factors may influence a child’s development and long-term health outcomes. Developmental programming (DP) is central to this paradigm, whereby specific early life exposures during critical periods of development are associated with changes to physiological and metabolic pathways, potentially predisposing individuals to disease. However, no standard definition of DP exists, and various terms have been used to describe similar processes. This analysis aimed to develop a conceptual definition for DP to inform interdisciplinary research, education, and practice. Walker and Avant’s eight-step method was employed to analyze the literature, …

Transcultural Headache Medicine: A Framework For Integrating Cultural Contexts Into Headache Science And Care - A Call To Action From The International Headache Society., Mario F. P. Peres, Giancarlo Lucchetti, Homero Vallada, Ivy L. Riso, Georgia K. Westenhofen, Marcelo Moraes Valença, Juliana Ramos De Andrade, K. C. Brennan, Morris Levin, Tsubasa Takizawa, Zhao Dong, Yonggang Wang, Wanakorn Rattanawong, Henry Riyanto Sofyan, Massimo Leone, Freda Dodd-Glover, Hsiangkuo Yuan, Abdulrazaq Albilali, Taoufik Alsaadi, Leonardo Caixeta, Anna P. Andreou, Peter J. Goadsby, Antoinette Maassenvandenbrink, Sait Ashina, Rami Burstein, Patricia Pozo-Rosich, Fayyaz Ahmed, Shuu-Jiun Wang

Department of Jefferson Headache Center Papers and Presentations

Headache disorders are among the most disabling neurological conditions, affecting over 1.5 billion people globally. Despite advances in pharmacological therapies, major inequities persist due to underdiagnosis, undertreatment and limited access to effective care, particularly in low- and middle-income countries. Social determinants of health, including cultural meanings, language and health beliefs, are increasingly recognized as key drivers of disparities in burden, diagnosis and treatment outcomes. Traditional medicine, used by more than 80% of the global population, remains first-line care in many regions and continues to influence therapeutic choices in high-income settings. Major systems such as Ayurveda, Traditional Chinese Medicine, Unani and …

3-Deoxyanthocyanidins Inhibit Β-Amyloid Aggregation, Toxicity, And Mitochondrial Dysfunction: Evidence From Mc-65 Cells And Molecular Dynamics Simulations, Rasheed A. Abdulraheem, Ammar U. Danazumi, Philipp Nitschke, Luke Gray Whiley, Abdulrahman Ibrahim Tudu, Ranil Coorey, Zhoyu Li, Prashant Bharadwaj, Vijay Jayasena, Stuart K. Johnson, Ralph N. Martins, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Accumulation of amyloid-beta (Aβ42) senile plaques in the brain is a hallmark of Alzheimer's disease (AD). Although some drug have been approvaled recently, none has demonstrated robust disease-modifying outcome. The 3-deoxyanthocyanidins (3-DXA) and their derivatives represent a more stable class of polyphenols, present at uniquely high concentrations in sorghum grains. Although 3-DXA exhibit strong potential to modulate protein aggregation processes, their effects on AD pathology remain unexplored. In this study, we investigated the inhibitory effects of three 3-DXA derivatives, apigeninidin chloride (AC), luteolinidin chloride (LC), and 7-methoxy apigeninidin (7-MAC), on Aβ42 aggregation and associated neurotoxicity. Thioflavin T fluorescence assay was …

Disuse-Induced Muscle Atrophy And Muscle Weakness From Hospitalization To Spaceflight: Exercise Succeeds In Prevention And Treatment—A Meta-Analysis, Camila S. Padilha, Figueiredo, Rafael Deminice, S. Ribeiro, Robert U. Newton, Nicolas H. Hart, José Cesar Rosa-Neto, Marília Seelaender, Fábio Santos Lira

Research outputs 2022 to 2026

Background: Exercise has been proposed as both a preventive and therapeutic countermeasure; however, its effectiveness across different disuse conditions and timings of implementation remains uncertain. Methods: This systematic review and meta-analysis (PROSPERO: CRD42021256599) searched ClinicalTrials.gov, Cochrane Central, PubMed, SPORTDiscus, Web of Science, Scopus, CINAHL and SciELO from inception to May 2021, with an update in March 2025. Randomized and nonrandomized controlled trials examining exercise interventions during or after muscle disuse were included according to the PICOS framework. Random-effects meta-analysis evaluated effects on muscle strength, power and mass across hospitalization, bed rest and spaceflight conditions. Effect sizes (ES) are reported as …

Comparison Of Levels Of Bmi, Stress, And Depression Of Women During The Prenatal Period Relative To Their Activity Levels, Kalayna King

Honors Theses

This study aimed to analyze the relationships between activity levels, Body Mass Index (BMI), stress levels, and depression symptoms in obese pregnant women in Arkansas. Two separate exercise intervention studies were combined in this analysis to ultimately give a sample size of 293 pregnant women who were randomized into standard of care group (control) and an exercise group (treatment/experimental) (n = 115 and n = 178, respectively). Women in the control groups were instructed to independently continue to follow the physical activity guidelines recommended by their gynecologist, whereas the experimental groups participated in a combination of aerobic and resistance exercise …

White Matter Microstructure Alterations In Social Anxiety Disorder: A Mega-Analysis Across Twelve Cohorts In The Enigma-Anxiety Working Group, Eline F Roelofs, Nynke A Groenewold, Kinga Farkas, Alyssa H Zhu, Si Gao, Tiana Borgers, Udo Dannlowski, Kira Flinkenflügel, Dominik Grotegerd, Tim Hahn, Andreas Jansen, Elisabeth J Leehr, Tilo T J Kircher, Hannah Meinert, Igor Nenadić, Frederike Stein, Benjamin Straube, Tamer Demiralp, Raşit Tükel, P Michiel Westenberg, Jochen Bauer, Anna Kraus, Alexander G G Doruyter, Christine Lochner, David Hofmann, Thomas Straube, André Zugman, Monica E Calkins, Raquel E Gur, Ruben C Gur, Bart S Larsen, Theodore D Satterthwaite, Theresa M Slump, Roman A Vogler, Suzanne N Avery, Jennifer U Blackford, Jacqueline A Clauss, Su Lui, Sophia I Thomopoulos, Robert R J M Vermeiren, Neda Jahanshad, Peter V Kochunov, Paul M Thompson, Daniel S Pine, Dan J Stein, Nic J A Van Der Wee, Janna Marie Bas-Hoogendam

Faculty, Staff and Student Publications

Background: Studies investigating social anxiety disorder (SAD) have reported inconsistent alterations in white matter (WM) microstructure. The ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)-Anxiety Working Group investigated differences in the microstructure of 25 WM tracts between individuals with SAD and healthy control (HC) participants in a mega-analysis.

Methods: We analyzed data from 487 individuals with SAD and 1604 HC participants (ages 8-65 years) from 12 cohorts worldwide. Analyses and quality control were performed using standardized ENIGMA diffusion tensor imaging protocols. We primarily examined fractional anisotropy (FA) as the main parameter of WM microstructure. Linear mixed-effects analyses were conducted to …

Electromyography, Prosthetic Properties, And Running Biomechanics In Recreationally Active Persons With Lower Extremity Amputation, Paige M. Agnew

Rehabilitation Sciences Theses & Dissertations

Lower extremity loss affects nearly 150,000 individuals in the United States yearly yielding extreme health care costs annually. Typically, prosthetic devices are prescribed for 5-8 years despite known changes to an individual’s gait as time progresses. Patients can expect to undergo approximately 8-12 weeks of gait retraining to improve their comfort and efficiency. Biomechanical changes occur when running with a specific running prosthetic including considerable biomechanical and neuromuscular interlimb asymmetries and alterations in loading patterns. The purpose of this dissertation was to investigate the biomechanical demands for lower extremity prosthesis users during running. The first study synthesized peer reviewed evidence …

“Recollecting The Told Story”: Storytelling, Activism, And The Black Maternal Health Emergency, Lamaya C. Williams

English Theses & Dissertations

Storytelling is a foundational component of Black knowledge creation and transmission. This dissertation centers Black women’s stories of birth and mothering—drawing on both primary source birth stories and fictional narratives—to examine the United States’ Black Maternal Health Emergency (BMHE). The BMHE is a complex and urgent issue wherein structural racism, medical bias, and intersecting social determinants disproportionately endanger the health of Black mothers. As such, Black mothers in the United States are three times more likely to die from a pregnancy-related condition compared to their white counterparts.

This study examines the birth stories of women who survived the BMHE and …

The Effects Of Covid 19 Job Demands On Public Sector Employees’ Organizational Commitment: The Mediating Roles Of Work Engagement And Job Burnout, And The Moderating Role Of Supervisor Support, Benjamin R. Kaufman

Psychology Theses & Dissertations

United States citizens rely on state government employees to provide essential public services. During the COVID-19 pandemic, these employees responded by administering both routine and novel procedures to protect public health, often placing them on the frontlines and at increased risk of contagion. Concurrently, the pandemic-driven economic downturn created budget shortfalls that threatened the job and financial security of the state workforce. Together, these conditions substantially increased job demands for state government employees.

Guided by the Job Demands–Resources (JDR) Model, this study examined how COVID‑19-related job demands influenced state employees’ work engagement, job burnout, and organizational commitment, and whether supervisor …