Digital Commons Network^™

Tumor Implantation Site Of Syngeneic Oral Cancer Models Differentially Induces Site-Dependent Local And Systemic Immunosuppression, Andrea H Molina, Gemalene M Sunga, Shawn Nguyen, Neeraja Dharmaraj, Ratna Veeramachaneni, Roberto Rangel, Jeffrey N Myers, Jeffrey D Hartgerink, Andrew G Sikora, Simon Young

Faculty, Staff and Student Publications

Background/objectives: Preclinical studies of head and neck squamous cell carcinoma (HNSCC) commonly use subcutaneous heterotopic (flank) tumor models for simplicity; however, orthotopic models may better reflect the native tumor environment. Direct comparisons of the tumor immune microenvironments (TIME) and tumor-draining lymph nodes (tdLNs) between these models remain limited. Better understanding of site-specific immune differences could improve model selection and interpretation of translational HNSCC studies.

Methods: ROC1 tumors were established in murine heterotopic and orthotopic sites, followed by assessment of tumor growth kinetics, survival, and the tumor microenvironment. Immune composition of tumors, blood, tdLNs, and spleen was evaluated at three tumor …

Evaluation Of Two Bioaerosol Sampling And Analysis Methods For The Collection Of Airborne Bacteria And Viruses, Elizabeth Detrick

UNLV Theses, Dissertations, Professional Papers, and Capstones

Bioaerosols, defined as airborne particles of biological origin, include bacteria, fungi, viruses, and their byproducts. They are ubiquitous in both indoor and outdoor environments and can cause respiratory infections, allergic reactions, and toxin-mediated illnesses. Air sampling plays a vital role in bioaerosol monitoring by enabling the collection and analysis of airborne microorganisms to assess exposure risk and inform mitigation strategies. The objective of this study was to determine the relative collection efficiency of two air samplers, the MD8 Airscan, a filtration sampling method, and the SKC BioSampler, an impingement sampling method. Aerosolization tests were conducted in a controlled test chamber …

Cortical Bone Density And Thickness Assessment Of Intraradicular Sites In Adolescent Patients Using Cbct Imaging, Sara Endo

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: The indications for the use of cone beam computed tomography (CBCT) in orthodontics has grown since it was first introduced and dentists are discovering new ways that 3D images enhance diagnosis and treatment planning. Evaluating bone quality and quantity can be measured as bone density and thickness in CBCT imaging and is helpful for temporary anchorage device (TAD) placement in orthodontic treatment. TADs rely on primary stability and are commonly used in orthodontic treatment to increase anchorage and expand the limit that nonsurgical orthodontics can provide.

Objectives: This study aims to assess the bone thickness and density at different …

Correlation Between Maxillary Transverse Width, Alveolar Housing Width And Palatal Bone Thickness: A Cbct Retrospective Study, Eric G. Hollensbe

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background:

Accurate assessment of transverse maxillary dimensions and surrounding bone morphology is critical for safe orthodontic treatment planning. Orthodontic expansion should remain within the biological limits of the alveolar housing and palatal bone to prevent adverse periodontal outcomes, including dehiscence, fenestration, and gingival recession. Standard diagnostic methods, such as dental casts and two-dimensional radiographs, offer limited information about the three-dimensional anatomy that restricts orthodontic tooth movement. Cone-beam computed tomography (CBCT) provides detailed evaluation of skeletal dimensions and cortical bone boundaries. This study aimed to examine the relationships among maxillary transverse width, alveolar housing thickness, and palatal thickness using CBCT imaging. …

The Impact Of Youth Sport On Occupational Balance: A Survey Study, Sean Jones

UNLV Theses, Dissertations, Professional Papers, and Capstones

Youth sport has been highly researched, exploring both positive and negative health impacts (Adetunji & Akendutire, 2017; Brengtsson et al., 2025; Conway, 2024; Hoffman et al., 2022). Despite the high prevalence of youth sport participation, and variability of health-related outcomes, there has been no research regarding the impact youth sport participation has on occupational balance, an occupational therapy concept that has been linked with overall health and well-being (Park et al., 2021). A mixed-methods, cross-sectional survey study was used to gain better insights into the impact youth sport participation may have on occupational balance. A sample size of 466 Nevada …

Thermal Physiological Ecology Of The Relict Leopard Frog At Hot And Cold Springs, Robert P. Pelletier Iii

UNLV Theses, Dissertations, Professional Papers, and Capstones

The relict leopard frog (Rana onca) once ranged across drainages in southern Nevada, northwestern Arizona, and southwestern Utah. Following a decline, the species only persisted in a few geothermally influenced hot springs, which led to the perspective that hot springs were high-quality habitat. Rana onca has been under intensive, multiagency management and the species has been translocated to establish additional populations, including at cold-water sites. Three research studies are presented into the thermal physiological ecology of R. onca with the aim of informing conservation strategy. The research was focused at a thermally influenced hot spring and a cold-water spring to …

Exploring Lifestyle Habits Between Gamers And Non-Gamers: A Survey-Based Approach, Janavi Sathappan

UNLV Theses, Dissertations, Professional Papers, and Capstones

Video gaming is a prevalent and meaningful occupation for a growing number of young adults, yet its relationship to health behaviors is inconsistent and unclear in literature. This cross-sectional survey-based study examined the differences in nutritional pattens, sleep hygiene, and physical activity between self-identified gamers and non-gamers in a sample of young adults aged 18-34. Recruitment occurred primarily through the University of Nevada, Las Vegas and associated networks. Participants were asked to complete the Mini Eating Assessment Tool, Sleep Hygiene Index, and the International Physical Activity- Short Form. Data was analyzed using Mann-Whitney U tests and Pearson’s chi-square tests, and …

Exploring The Biological Basis For Exercise Neuroprotection In Parkinson’S Disease: A Cross-Sectional Study Of Exercise And Physical Activity On Inflammatory Cytokines And Neurotrophins, Leah Isabelle P. Alegre, Jacob M. Brewer, Adeline Florschutz, Kate E. Hamiltonthompson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Regular exercise and physical therapy are known to increase production of neurotrophins, including brain-derived neurotrophic factor (BDNF), and anti-inflammatory cytokines. These changes combine to theoretically protect and slow the progressive loss of neurons in Parkinson’s disease (PD). The purpose of this study was to examine the effect of exercise and physical activity on various anti-inflammatory and pro-inflammatory cytokines and neurotrophins in people with PD (PwP). This was a cross-sectional design involving PwP (n=37), aged 43-85 years, who participated in two 30-minute bouts of exercise (with brief rest breaks during and pre/post blood draws) separated by a week. Measures collected prior …

Anatomy Academy: An Interdisciplinary Approach To Enhancing Youth Health Literacy, Roselle Antikoll, Jonathan Nakamine, Jessica Tran

UNLV Theses, Dissertations, Professional Papers, and Capstones

To enhance health literacy among the underserved youth population in Las Vegas, Nevada, Anatomy Academy (AA) is an eight-week, seven-lesson program that educates students through structured and interactive lesson plans covering basic anatomy, physiology, and nutrition. Our program was implemented in three different Title-I elementary schools between five different classrooms across Las Vegas. These lesson plans highlighted specific body systems including the cardiovascular, musculoskeletal, and gastrointestinal systems. Our primary aim was centered around involvement of more interdisciplinary healthcare professions including occupational therapy, dental medicine, osteopathic medicine, and nutrition to aid in the delivery of the AA program. Our secondary aim …

Postural And Load Dependent Modulation Of Lower Limb H-Reflex Excitability After Stroke, Daniel Bamiro, Matthew Berdiago, Ethan Hunter, Tia Nguyen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis

Leg stiffness is regulated by reflexive, intrinsic, and passive mechanisms, which are influenced by posture, body weight loading, and motor task demands. After a stroke, the capacity to modulate these mechanisms is often compromised. The H-reflex is a widely used electrophysiological tool to assess the excitability of the Ia afferent pathway within spinal circuitry. Although prior studies in healthy individuals have examined limb loading effects, results have been variable, and the role of postural and loading changes during standing remains underexplored, particularly in individuals post-stroke. This study investigated how different postural and limb loading conditions, specifically prone, standing, and …

Effect Of An Exercise Protocol On Balance In Adults With Down Syndrome, Juan Bernal, Natalie Sato

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis: Down syndrome (Ds) is a complex genetic condition that can impact multiple systems of the body, including functional balance. Ds-specific impairments such as muscle hypotonia, ligamentous laxity, and decreased muscle strength, coupled with a sedentary lifestyle can result in poor motor control, altered proprioceptive function, static and dynamic instability. Visual and vestibular impairments are also common in this population, increasing fall risk and fear of falling, and discouraging participation in physical activity. The aim of this study is to analyze the impact of a physical therapy-based exercise program on the functional balance of adults with Ds.

Number of Subjects: …

Effectiveness Of Cognitive Stimulation Therapy On The Quality Of Life Of Adults With Dementia: A Secondary Analysis, Evelyn Airam

UNLV Theses, Dissertations, Professional Papers, and Capstones

This secondary analysis study evaluated the effectiveness of Cognitive Stimulation Therapy (CST) on quality of life (QoL), depressive symptoms, and cognitive function in 108 community-dwelling older adults with cognitive impairments, including dementia. Outcomes involved Quality of Life (QoL) measured by the Quality of Life in Alzheimer’s Disease (QoL-AD), symptoms of depression by the Cornell Scale for Depression in Dementia (CSDD), and cognitive function using the Saint Louis University Mental Status (SLUMS). After the CST, significant improvements were observed in QoL (p = .004), depressive symptoms (p = .002), and cognitive function (p < .001), with small effect sizes. Additionally, a significant interaction between sex and dementia diagnosis status was found in predicting cognitive changes, suggesting that the relationship between dementia diagnosis and cognitive improvement differs by sex. No between-group differences were found for QoL or depression. Findings support CST as a multidimensional, non-pharmacological intervention that improves cognitive, psychological, and social outcomes. Although effects were small, consistent improvements are clinically meaningful given the progressive nature of dementia. This study extends existing literature by demonstrating CST’s effectiveness in a community-based setting and reinforces its alignment with occupational therapy’s emphasis on participation and holistic care. Results highlight the need for early intervention and expanded access to CST programs to enhance quality of life in this population.

Unknowing Sacrifices: Public Health And Radiation Illness In New Mexico And Nevada, 1940s-1960s, Beatriz Avila-Marquez

UNLV Theses, Dissertations, Professional Papers, and Capstones

The detonation of the first atomic bomb in the early morning of July 16, 1945, in New Mexico welcomed the atomic age that forever changed the world. After that day, thousands of lives were lost due to nuclear weapons, and hundreds of thousands more continued to suffer from the effects of atomic testing. The Atomic Energy Commission, fueled by the arms race of the Cold War, chose Nevada to continue the United States’ nuclear weapons testing. Knowledge of the dangers of radiation exposure, the effects of radiation, and techniques to prevent exposure are now available in part due to the …

Fostering Adolescents’ Social-Emotional Skills In A Community Setting, Elizabeth Benitez

UNLV Theses, Dissertations, Professional Papers, and Capstones

Adolescents face growing emotional, behavioral, and social challenges, especially in community recreation settings with high energy, peer interaction, and sensory demands. These environments often expose difficulties in emotional regulation, communication, and conflict management, highlighting the need for structured social-emotional learning (SEL). This capstone project aimed to develop and implement an occupation-centered SEL program integrating the Zones of Regulation (ZOR), CASEL competencies, and Developmental, Individual Differences, Relationship-Based (DIR) Floortime principles within the Clark County Hollywood Parks and Recreation after-school program. Guided by the Person–Environment–Occupation (PEO) model, the project sought to help adolescents practice emotional awareness, self-management, and interpersonal skills in their …

Got Sleep?: The Introduction Of Sleep Hygiene To Justice Involved Individuals, Charisma Lynn Cato

UNLV Theses, Dissertations, Professional Papers, and Capstones

Individuals transitioning out of incarceration often experience challenges with sleep due to the residual effects of confinement. Although this is common among justice-involved individuals, there is limited research on how to address their sleep hygiene self-efficacy after release. Furthermore, despite the wide use of social-emotional learning (SEL) across multiple disciplines, little is known about its influence on sleep-related behavior change in re-entry populations. To address this, the Got Sleep program, designed and implemented at Hope for Prisoners (HOPE), a community site geared toward re-entry assistance, integrated occupational therapy (OT) principles and an SEL approach with practical sleep hygiene strategies to …

Inclusiveness With Sensory Maps; Enhancing Engagement In A Children's Museum, Victoria E. Davila

UNLV Theses, Dissertations, Professional Papers, and Capstones

Sensory processing challenges can affect a child’s ability to engage in play, especially when participating in community activities. When a child feels overwhelmed by sensory features in an environment, such as noise or bright lights in a community space, they may experience sensory overload. Caregivers often observe this behavior but may not have access to resources to help their child navigate these challenges. This capstone project aimed to implement a program development initiative at the Discovery Children’s Museum focused on developing sensory-inclusive resources for caregivers visiting the museum with a child. The role of occupational therapy in this project is …

The Lotus Project: An Occupation-Based Online Module To Support Healthy Matrescence, Virginia Genato

UNLV Theses, Dissertations, Professional Papers, and Capstones

Becoming a mother is a meaningful life event that occurs amid complex physical, psychological, and social changes. During this period, individuals undergo an occupational role transition as they assume new caregiver responsibilities while navigating contextual demands. The ease of this transition influences overall maternal adjustment. The dominant sociocultural model of intensive mothering promotes child-centered caregiving, often at the expense of maternal well-being and adjustment. Efforts to meet these expectations may disrupt an individual’s transition into motherhood and place them at risk for developing postpartum mental health challenges.

The concept of matrescence provides a developmental framework that views motherhood as an …

Establishing A Comprehensive Framework For Sfrt Lattice Treatments: Optimization, Planning, And Clinical Evaluation, Gregory M. Gill

UNLV Theses, Dissertations, Professional Papers, and Capstones

Spatially fractionated radiation therapy (SFRT) using lattice radiotherapy (LRT) has emerged as a promising treatment technique for bulky, nonresectable tumors by delivering spatially heterogeneous dose distributions consisting of high-dose vertices embedded within lower-dose regions. Although early clinical experiences have demonstrated potential therapeutic benefit, widespread clinical implementation of LRT remains limited due to the absence of standardized treatment planning workflows, consistent optimization strategies, and clearly defined evaluation metrics for heterogeneous dose distributions. The objective of this study is to develop and evaluate a structured framework to support efficient, reproducible, and safe clinical implementation of LRT.

To address these challenges, a comprehensive …

Feasibility Of High-Intensity Training (Hit) For Academic Engagement In Young Adult Women, Raleah Tenorio Kastner

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose: This feasibility study aimed to identify the impact of a high-intensity training (HIT) exercise protocol on healthy behaviors related to academics to decrease stress levels and enhance academic engagement and overall quality of life in young adult female students, measured by a modified version of the National Survey of Student Engagement (NSSE) and the Occupational Experience Profile (OEP).

Methodology: One young adult female student enrolled at UNLV who is 18-25 years old was recruited via convenience sampling to engage in a 12-session HIT exercise program, developed by a certified personal trainer and licensed occupational therapist, with the participant’s target …

A Comparison Of Changes In Vertical Cephalometric Measurements In Patients Treated With Invisalign And Traditional Fixed Orthodontic Appliances: A Retrospective Study, Shayna Mesko

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Since their introduction into the field, clear aligners have significantly grown in popularity in orthodontics as they offer enhanced esthetics, improved oral hygiene, and patient comfort. Clear aligners have allowed clinicians to simulate treatment outcomes, streamline treatment with reduced office visits, control force and movement per tray, and provide more precise control of focal tooth movements. This can enhance efficiency in achieving specific and very finite orthodontic goals. Since their inception, clear aligners have evolved from only accomplishing simple tooth movements to achieving more complex and comprehensive mechanics. While they have significantly advanced, there are still limitations in efficacy …

Addressing Sleep Health In The Fire Service: A Sleep Hygiene Education Program, Alyssa Elizabeth Neal

UNLV Theses, Dissertations, Professional Papers, and Capstones

This capstone project implemented an occupational therapy sleep hygiene program tailored to the unique occupational demands of Las Vegas Fire and Rescue (LVFR) firefighters. Guided by the Occupational Adaptation theory and the CALMS Framework, this project conceptualized sleep as a meaningful occupation essential to health, safety, and functional performance. The project’s aim was to assess the feasibility of a sleep hygiene program designed for the fire service using standardized measures, including the Sleep Hygiene Index. The methodology incorporated a structured educational session focused on educating firefighters on the importance of sleep, modifying routines and environments to support restorative sleep, implementing …

Correlation Between Maxillary Sinus Volume And Maxillomandibular Size, Position, And Dental Occlusion: A Cbct Retrospective Study, Philip Villanueva Punzalan

UNLV Theses, Dissertations, Professional Papers, and Capstones

This investigation used cone beam computed tomography (CBCT) based three dimensional imaging to evaluate correlations between maxillary sinus volume and maxillomandibular skeletal size, position, and dental occlusion in an adult orthodontic population. A retrospective sample of 107 pretreatment CBCT scans (40 males and 67 females), aged 18–59 years, was analyzed. Right and left maxillary sinuses were segmented independently using semi-automatic volumetric segmentation in ITK-SNAP software, and total sinus volume was calculated in cubic millimeters (mm³). Linear and angular skeletal measurements of the maxilla and mandible were obtained using Anatomage TxSTUDIOViewer application software. Patients were categorized according to anteroposterior (A-P) skeletal …

Exploring A Boxing Community Exercise Porgram For Women With Parkinson's Disease, Emily Truong

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective: The purpose of this capstone project was to explore the lived experiences of 10 women with Parkinson’s disease (PD) who participate in the Rock Steady Boxing (RSB) program, an exercise community-based non-contact boxing program. Because women remain underrepresented in PD research and exercise-based interventions, this project aims to better understand how women perceive the physical, emotional, and social impacts of participating in RSB.

Methods: This qualitative case series included 10 women diagnosed with PD that participate in RSB at the Tony Cress Training Center. Data was collected through individual semi-structured interviews and audio recordings. Interviews were consented, transcribed verbatim, …

Quantification Of Sarm1 Nadase Activity In Human Peripheral Blood Mononuclear Cells, Lila F Dabill, Ivana R Shen, Jennifer M Brazill, Alicia Neiner, Yo Sasaki, Erica L Scheller

2020-Current year OA Pubs

SARM1 (sterile α and TIR motif-containing protein-1) is an NADase enzyme that serves as the central executioner of Wallerian axon degeneration. Given this, SARM1 is of high interest as a candidate therapeutic target, and SARM1 inhibitors are currently in clinical trials for treatment of neurodegeneration. Beyond neuroscience, emerging studies reveal that SARM1 may also drive aspects of bone fragility, liver pathology, adipose expansion, and insulin resistance in metabolic disease. However, we lack methods to quantify SARM1 activation in humans to better define patients at high risk of SARM1-mediated tissue damage. Unlike neurons, peripheral blood mononuclear cells (PBMCs) represent an easily …

Subclinical Neuropsychiatric Trait Variation In Parents Of Children With Autism Spectrum Disorder: A Cohort Study, Lindsay J Mullin, Carolyn Lasch, Natasha Marrus, Et Al.

2020-Current year OA Pubs

BACKGROUND: Many neuropsychiatric conditions share overlapping features underpinned by shared genetics. In this study, we examined the co-aggregation of sub-threshold variation in neuropsychiatric phenotypes in biological parents of autistic children to provide insights into the intergenerational transmission of genetic liability for autism.

METHODS: Autistic, neuropsychiatric (i.e., anxiety, depression, ADHD), and cognitive traits were characterized in biological parents of children enrolled in a longitudinal developmental study: 189 families of autistic children and 100 families with no autistic children were included. Families were further characterized as having only one (simplex) or more than one (multiplex) autistic child. Maternal and paternal traits were …

Resilience Of Orthodontic Sealants Against Degradation And Microbial Adhesion: A Comparative Study, Michelle X. Cui

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background:

White spot lesions are one of the most common complications encountered during orthodontic treatment. These lesions begin as demineralization of enamel around the appliance due to plaque buildup, resulting in compromised aesthetics. As they continue to develop, white spot lesions progress to cavitation, potentially threatening pulpal vitality, resulting in an increased financial burden for patients. Preventative strategies include patient education, consistent oral hygiene protocols, and the use of fluoride-releasing agents. Orthodontic sealants such as Opal® Seal™ (Ultradent) (OS) and L.E.D. Pro Seal® (Reliance) (PS) have been developed to release and recharge fluoride, thereby reducing the incidence of white spot …

Correlation Of Buccolingual Angulation Of Posterior Teeth And Transverse Skeletal Width In Adult Orthodontic Patients: A Retrospective Cbct Study, Anya T. Hatfield

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective:

Accurate evaluation of transverse skeletal relationships is essential for orthodontic diagnosis and treatment planning. Dentition may compensate for skeletal discrepancies through buccolingual tipping of posterior teeth, potentially masking underlying transverse imbalance. The purpose of this study was to investigate the relationship between transverse skeletal width and posterior tooth angulation using cone-beam computed tomography (CBCT).

Methods:

Sixty-six pre-orthodontic adult CBCT scans were analyzed. Maxillary and mandibular transverse skeletal widths were measured at the level of the first molar furcation using buccal cortical plate– to–buccal cortical plate landmarks. Buccolingual angulation of the first and second premolars and first and second molars …

Addressing Sexual Health For Older Veterans By Healthcare Providers: A Mixed Method Study, Andrew James White

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Older adults remain sexually active, yet sexual health is frequently under-discussed in healthcare settings, particularly within veteran populations. Sexual health is essential to overall quality of life, and prior studies have shown that older patients value these conversations. However, veterans often face unique factors such as military-related trauma, including military combat exposure and post-traumatic stress disorder, in addition to compounded stigma from these topics in regards to open discussions about sensitive health issues to their healthcare providers. This study is significant in its potential to uncover systemic, cultural, and interpersonal influences that shape these dynamics, with a particular emphasis …

Multiscale Modeling Of Chemoattractant-Guided Collective Cell Migration In The Drosophila Egg Chamber, Lara Scott, Bradford E. Peercy, Meghan Kwon, Michelle Starz-Gaiano

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Epidemic Dynamics With Renewal Processes And General Lifetime Distributions, Divine Wanduku, Divine Wanduku

Biology and Medicine Through Mathematics Conference

No abstract provided.