Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1741 - 1770 of 9985

Full-Text Articles in Entire DC Network

Swimming Together Upstream: How To Align Mlp Services With U.S. Healthcare Delivery, William M. Sage, Keegan D. Warren Dec 2023

Swimming Together Upstream: How To Align Mlp Services With U.S. Healthcare Delivery, William M. Sage, Keegan D. Warren

Faculty Scholarship

Medical-legal partnership (MLP) embeds attorneys and paralegals into care delivery to help clinicians address root causes of health inequities. Notwithstanding decades of favorable outcomes, MLP is not as well-known as might be expected. In this essay, the authors explore ways in which strategic alignment of legal services with healthcare services in terms of professionalism, information collection and sharing, and financing might help the MLP movement become a more widespread, sustainable model for holistic care delivery.


The Quality Of Life In Assisted Living Facilities In Grand Rapids, Nina Alpers Dec 2023

The Quality Of Life In Assisted Living Facilities In Grand Rapids, Nina Alpers

Honors Projects

This research study looked at the quality of life of residents in assisted living facilities in Grand Rapids. The purpose of this study is to consider the life satisfaction of residents of assisted living facilities in Grand Rapids and explore the determinants that can make their time spent at assisted living facilities as enjoyable as possible. This study highlighted the voices of the residents in assisted living facilities by doing a qualitative study using an interview-styled approach that asked the residents about a variety of topics, such as routines, feelings, values, personal facts, health status, care provided, relationships, and views …


An Analogue Study Of Expected Working Alliance And Hope With Victims Of Military Sexual Trauma Among Civilian And Military-Oriented Therapists, Alishia D. Salyer Dec 2023

An Analogue Study Of Expected Working Alliance And Hope With Victims Of Military Sexual Trauma Among Civilian And Military-Oriented Therapists, Alishia D. Salyer

Dissertations

Victims of military sexual trauma (MST) face unique challenges as they pursue mental health treatment and supportive care. Understanding what factors impact potential treatment outcomes is critical in aiding in their recovery (Castro et al., 2015; Kroviak, 2020). Although a substantial amount of research has been conducted to evaluate prevalence and client factors associated with treating victims of MST (Teit et al., 2015; Turchik & Wilson, 2010), little is known about therapists’ factors including therapists’ expectations working with such clients. The purpose of this study was to examine the relationships between therapist type (military-affiliated versus civilian), therapist gender, client gender, …


Barriers In Immigrant Mental Healthcare: Women, Children And Fathers, Alisa Pickett Dec 2023

Barriers In Immigrant Mental Healthcare: Women, Children And Fathers, Alisa Pickett

Honors Theses

The American Psychological Association has identified immigrant families as a vulnerable population, whose access to mental healthcare is impacted by numerous barriers (DeAngelis, 2023). Within these communities there is a need for mental health resources, but due to the many barriers these communities face they are often left without care. In this literature review, I will identify the mental health needs, and the barriers that each member of the family (e.g., mothers, children, and fathers) uniquely faces. The discussion will review how these barriers are currently being addressed, specifically looking at changes within practices, use of logotherapy, and changing the …


Unmasking And Addressing Burnout In The Mental Health Profession, Sara Edwards Dec 2023

Unmasking And Addressing Burnout In The Mental Health Profession, Sara Edwards

University Honors Theses

Burnout poses a significant challenge among mental health workers, impacting both the well-being of practitioners and the outcomes for their patients. The key inquiries guiding this literature review are: what factors contribute to burnout, and what interventions are essential for treating and preventing burnout in mental health professionals? The findings reveal that factors such as level of experience, lack of quality supervision, vicarious trauma, working conditions, and personal beliefs significantly contribute to burnout. Effective prevention and treatment measures for mental health workers vulnerable to burnout encompass self-monitoring, participation in support groups, additional training, and organizational interventions. These insights could serve …


Emergency Department Patient Navigator Post Chest Pain Diagnosis Discharge, Nancy Simoes Dec 2023

Emergency Department Patient Navigator Post Chest Pain Diagnosis Discharge, Nancy Simoes

Seton Hall University Dissertations and Theses (ETDs)

Abstract The most common complaint seen in the Emergency Department, along with abdominal pain, is nonspecific chest pain. Often, these complaints cause prolonged lengths of stay in the ED, followed by hospital admissions and subsequent readmissions for various reasons. When thinking about these various reasons, the question for prevention of readmission comes to mind. What could we do as a department to keep patients from continuously using the Emergency Department as a primary point of care instead of outpatient facilities when necessary? Project Aim: The purpose of this quality improvement project was to initiate the need for a patient navigator …


Examining College Students’ Attitudes Toward Poverty During The Adult Role Of The Community Action Poverty Simulation, Jessica M. Parks, Portia Johnson, Diann C. Moorman, Sheri Worthy, Leigh Anne Aaron Dec 2023

Examining College Students’ Attitudes Toward Poverty During The Adult Role Of The Community Action Poverty Simulation, Jessica M. Parks, Portia Johnson, Diann C. Moorman, Sheri Worthy, Leigh Anne Aaron

Journal of Human Sciences and Extension

Family and Consumer Sciences (FCS) and Extension professionals need to understand the lived experience of poverty because it affects every aspect of an individual’s life. Poverty is related to inadequate nutrition and food insecurity, lack of access to health care, insufficient child care, unsafe neighborhoods, lack of affordable housing, under-resourced schools, and a lower quality of life. Attitudes toward poverty vary widely among Americans and can be categorized as either internal/individual attributions (e.g., laziness, welfare dependency, etc.) or systemic/structural attributions (e.g., unemployment, inflation, etc.). Individuals holding internal attributions toward poverty are more likely to have negative feelings toward impoverished individuals. …


The Exploration Of Perceptions Of Patient-Clinician Communication In Black Mothers Diagnosed With An Acute Post-Partum Hypertensive Crisis, Melanie P. Fant Dec 2023

The Exploration Of Perceptions Of Patient-Clinician Communication In Black Mothers Diagnosed With An Acute Post-Partum Hypertensive Crisis, Melanie P. Fant

Theses and Dissertations (ETD)

For Black American mothers, postpartum stressors are magnified as about half of this population are single mothers, and many suffer from inadequate social and healthcare needs. Expected postpartum stressors, coupled with social stressors that Black American mothers face, can mask or influence patient reporting of early postpartum hypertensive crisis symptoms. Patients diagnosed with preeclampsia risk developing even more severe complications, such as cardiovascular disease, which is the leading cause of pregnancy-related deaths in the United States. Black American women face the challenge of inadequate communication with their healthcare providers, medical mistrust, and perceived discrimination when accessing health care. Pregnant women, …


Spotlight On Mental Health On A Healthcare Campus: An Assessment Of Psychological Trauma Awareness, Training, And Treatment In The University Of Nebraska Medical Center College Of Public Health Community, Jenny E. Mueller Dec 2023

Spotlight On Mental Health On A Healthcare Campus: An Assessment Of Psychological Trauma Awareness, Training, And Treatment In The University Of Nebraska Medical Center College Of Public Health Community, Jenny E. Mueller

Capstone Experience: Master of Public Health

Background: Psychological trauma has been recognized as a public health concern of epidemic proportions globally. Public health community awareness of and education in trauma is likely to be integral to preparing future public health professionals to work effectively and safely in the field. Currently, the extent of trauma awareness, training, and treatment on the University of Nebraska Medical Center College of Public Health (UNMC COPH) campus is not known.

Aims: The aims of this project are to investigate and assess the level of psychological trauma awareness, training, and treatment on the UNMC COPH campus; and to provide recommendations for actions …


Design Guidelines For Homeless Shelter And Resource Center Site Plans, Samuel Johnson Dec 2023

Design Guidelines For Homeless Shelter And Resource Center Site Plans, Samuel Johnson

All Graduate Reports and Creative Projects, Fall 2023 to Present

Homelessness is one of the most pressing humanitarian issues facing the country today. Lack of affordable housing, among many other complicating factors, have led to many cities scrambling to find both short-, middle-, and long-term solutions to the issue. The Covid-19 pandemic added a disruption in services, critical record-keeping, and data-gathering, which has further confounded experts looking for an effective path forward. As it stands, there is a significant gap in academic research addressing best practices for shelter site design, particularly as it relates to landscape. The role of landscape and greenspace within and around a shelter is not well …


The Predictability Of Body Types, Socio-Demographics And Attitudes Toward Body Factors On The Self-Esteem Of College Students, Pantea Mohammadi Dec 2023

The Predictability Of Body Types, Socio-Demographics And Attitudes Toward Body Factors On The Self-Esteem Of College Students, Pantea Mohammadi

Dissertations (2016-Present)

Objective of the Study The purpose of this empirical investigation will be to determine the predictable relationship between body types of factors, socio-demographic factors, attitudes toward body factors and the self-esteem scores of undergraduate freshmen college students. More specifically, the study will be concerned with predictability of body types, socio-demographic, and attitudes toward body factors of body image, body appreciation, gender, age, physical attractiveness, and satisfaction with physical features of the body on the self-esteem scores among undergraduate freshmen college students. Answers to the following questions will be sought: 1. Do body type factors (body image and body appreciation) have …


Psychological Distress And Mental Health Care Utilization Among Hispanic/Latino Survivors Of Adolescent And Young Adult Cancer, Eunju Choi, Amy M Berkman, Christabel K Cheung, Andrea C Betts, John M Salsman, Clark R Andersen, Carol Yesenia Ochoa-Dominguez, Kimberly Miller, Joel Milam, Ashna Shah, Susan K Peterson, Qian Lu, J Andrew Livingston, Michelle A T Hildebrandt, Susan K Parsons, David Freyer, Michael E Roth Dec 2023

Psychological Distress And Mental Health Care Utilization Among Hispanic/Latino Survivors Of Adolescent And Young Adult Cancer, Eunju Choi, Amy M Berkman, Christabel K Cheung, Andrea C Betts, John M Salsman, Clark R Andersen, Carol Yesenia Ochoa-Dominguez, Kimberly Miller, Joel Milam, Ashna Shah, Susan K Peterson, Qian Lu, J Andrew Livingston, Michelle A T Hildebrandt, Susan K Parsons, David Freyer, Michael E Roth

Faculty, Staff and Student Publications

Purpose: Survivors of adolescent and young adult (AYA) cancer experience psychological distress and insufficient access to mental health care. Few studies have investigated racial/ethnic disparities in psychological health outcomes in this population. This study compared psychological distress, mental health care use, and inability to afford mental health care between Hispanic/Latino survivors of AYA cancer and Hispanic/Latino controls.

Methods: The National Health Interview Survey data (2010-2018) were analyzed to identify Hispanic/Latino survivors of AYA cancer and Hispanic/Latino age- and sex-matched non-cancer controls. Sociodemographic, chronic health, modifiable factors, and psychological outcomes were compared using chi-square tests. Logistic regression models with survey weights …


Food Insecurity At Los Abuelitos, Rosalina Duran Dec 2023

Food Insecurity At Los Abuelitos, Rosalina Duran

Capstone Projects and Master's Theses

Food insecurity among the senior population is a social problem that can cause malnutrition, chronic conditions, and death. CHISPA Housing Management and Community Services is a non-profit organization that builds low-income senior housing in Monterey County and provides senior hot lunches to its residents. The causes of food insecurity are a lack of income, chronic conditions, and transportation issues. The consequences of food insecurity are the deterioration of their physical and mental health. This capstone project is an assessment that consists of gathering data on the residents who reside at the Los Abuelitos Townhome housing rather than taking advantage of …


"My Gut Feeling Is…": An Ethnographic Study Exploring Interprofessional Communication About Children And Adolescents With Chronic Musculoskeletal Pain In Paediatric Rheumatology., Rebecca R. Lee, Janet E. Mcdonagh, Tim Rapley, Albert Farre, Mark Connelly, Tonya M. Palermo, Karine Toupin-April, Emily Wakefield, Sarah Peters, Lis Cordingley Dec 2023

"My Gut Feeling Is…": An Ethnographic Study Exploring Interprofessional Communication About Children And Adolescents With Chronic Musculoskeletal Pain In Paediatric Rheumatology., Rebecca R. Lee, Janet E. Mcdonagh, Tim Rapley, Albert Farre, Mark Connelly, Tonya M. Palermo, Karine Toupin-April, Emily Wakefield, Sarah Peters, Lis Cordingley

Manuscripts, Articles, Book Chapters and Other Papers

Interprofessional communication about inflammatory and non-inflammatory musculoskeletal conditions is an important component of assessment and management in paediatric rheumatology. Chronic pain is a feature of some of these conditions which likely influences the extent and type of communication about pain. Research investigating interprofessional communication about paediatric pain is limited but has found that communication is inclusive of the biopsychosocial context of children/adolescents as well as their families. The aim of this ethnographic study was to explore interprofessional communication about children and adolescents with chronic musculoskeletal pain in paediatric rheumatology. We observed forty-five healthcare professionals recruited from 3 UK paediatric rheumatology …


Job Characteristics That Enrich Clinician-Educators’ Career: A Theory-Informed Exploratory Survey, M Hossein Tcharmtchi, Shelley Kumar, Jennifer Rama, Brian Rissmiller, Danny Castro, Satid Thammasitboon Dec 2023

Job Characteristics That Enrich Clinician-Educators’ Career: A Theory-Informed Exploratory Survey, M Hossein Tcharmtchi, Shelley Kumar, Jennifer Rama, Brian Rissmiller, Danny Castro, Satid Thammasitboon

Faculty, Staff and Students Publications

Clinician educators (CEs) play a vital role in helping academic institutions achieve the missions of patient care, education and research. The driving forces that motivate pediatric CEs in professional growth and personal satisfaction remain unexplored. An exploratory survey research to investigate the job characteristics and factors that motivate CEs to pursue professional growth with personal satisfaction. Using the Job Characteristics Model (JCM) as a framework, we developed a 22-item survey comprised of the JCM derived Job Diagnostic Survey, Global Job Satisfaction scales and demographics. We collected data from January 2020 to March 2020 from self-identified pediatric CEs (with and without …


The Relationship Of Self-Care Behaviours And Online Learning Engagement Among Nursing Students During The Covid-19 Pandemic, Mazlinda Musa, Rohani Mamat, Hamidah Hassan, Sitti Fatimah Sa'at, Syed Syarizman Abd Rahim, Abdul Rahman Ramdzan, Octovia Abdullah, Vellerina Ally Paidius, Mariana Muitaba, Ashley Melissa George Nov 2023

The Relationship Of Self-Care Behaviours And Online Learning Engagement Among Nursing Students During The Covid-19 Pandemic, Mazlinda Musa, Rohani Mamat, Hamidah Hassan, Sitti Fatimah Sa'at, Syed Syarizman Abd Rahim, Abdul Rahman Ramdzan, Octovia Abdullah, Vellerina Ally Paidius, Mariana Muitaba, Ashley Melissa George

Jurnal Keperawatan Indonesia

The COVID-19 pandemic and the sudden switch from conventional to virtual classes allegedly raised students' risk of mental health illnesses, adversely influencing their academic engagement and learning outcomes. Nursing students in Malaysia, especially those enrolled in universities in Sabah, have traditionally been accustomed to a conventional face- to-face teaching and learning approach. Due to the COVID-19 pandemic, e-learning or online classes have become one of the learning methods for university nursing students in Sabah, either while they are on campus or at home, to obtain access for educational purposes. The purpose of this study was to assess the relationship between …


The Opportunities And Challenges Of Perioperative Therapy Of Localized Non-Small Cell Lung Cancer-Thoughts From The Keynote-671 Trial, Nathaniel Deboever, Jianjun Zhang Nov 2023

The Opportunities And Challenges Of Perioperative Therapy Of Localized Non-Small Cell Lung Cancer-Thoughts From The Keynote-671 Trial, Nathaniel Deboever, Jianjun Zhang

Faculty, Staff and Student Publications

No abstract provided.


Stigma And Mothers Using Opioids, Amelia Van Komen, Maren Wright Voss, Amy Campbell Nov 2023

Stigma And Mothers Using Opioids, Amelia Van Komen, Maren Wright Voss, Amy Campbell

All Current Publications

Parenting and pregnancy in the context of substance use is a complicated topic. Many public health officials, social workers, policy makers, and community members want to provide effective support and treatment for the child and for the parent. But when stigma, prejudice, or misinformation occur, parents who use substances can be exposed to added barriers to accessing care and support. This fact sheet addresses solutions to these barriers.


Latinx Social Work Students’ Well-Being Prior To And During The Covid-19 Pandemic, Leyla Feize Nov 2023

Latinx Social Work Students’ Well-Being Prior To And During The Covid-19 Pandemic, Leyla Feize

School of Social Work Faculty Publications

This is a reflection on social work students’ well-being before and during the COVID-19 pandemic. This narrative was indirectly written by the students, as it is their interpretations of their feelings, thoughts, and behaviors derived from drawing their own mandalas daily for one month. It is a comparison of two stories of struggle, hope, and change during two different periods which were close in time, but far in reality.


Formative Evaluation And Adaptation Of A Hypertension Extension For Community Health Outcomes Program For Healthcare Workers Within The Federal Capital Territory, Nigeria, Abigail S Baldridge, Nadia Goldstar, Grace C Bellinger, Abigail T Denoma, Ikechukwu A Orji, Gabriel L Shedul, Rosemary C B Okoli, Nanna R Ripiye, Adaora Odukwe, Olabisi Dabiri, L Nneka Mobisson, Dike B Ojji, Mark D Huffman, Namratha R Kandula, Lisa R Hirschhorn Nov 2023

Formative Evaluation And Adaptation Of A Hypertension Extension For Community Health Outcomes Program For Healthcare Workers Within The Federal Capital Territory, Nigeria, Abigail S Baldridge, Nadia Goldstar, Grace C Bellinger, Abigail T Denoma, Ikechukwu A Orji, Gabriel L Shedul, Rosemary C B Okoli, Nanna R Ripiye, Adaora Odukwe, Olabisi Dabiri, L Nneka Mobisson, Dike B Ojji, Mark D Huffman, Namratha R Kandula, Lisa R Hirschhorn

2020-Current year OA Pubs

BACKGROUND: The Extension for Community Health Outcomes (ECHO) model has been used extensively to link care providers in rural communities with experts with the aim of improving local patient care.

OBJECTIVE: The aim of this qualitative research study was to assess the feasibility, acceptability, perceived needs, and contextual factors to guide implementation of a hypertension focused ECHO program for Community Health Extension Workers (CHEWs) in the Federal Capital Territory, Nigeria.

METHODS: From September 2020 to December 2020, key informant interviews were performed with seven global organizations (hubs) providing ECHO training focused on cardiovascular disease or nephrology to identify contextual factors …


The 14-Day Rule For In Vitro Human Embryo Research Requires Adjustment: From A Comprehensive Perspective Of Science, Ethics And Policy Research, Xiao Lu, Ming Zhao, Huihui Liu, Tianqing Li, Tao Tan, Weizhi Ji Nov 2023

The 14-Day Rule For In Vitro Human Embryo Research Requires Adjustment: From A Comprehensive Perspective Of Science, Ethics And Policy Research, Xiao Lu, Ming Zhao, Huihui Liu, Tianqing Li, Tao Tan, Weizhi Ji

Bulletin of Chinese Academy of Sciences (Chinese Version)

Since it was proposed, in vitro human embryo research had been following the 14-day rule, which limited in vitro research on human embryos within 14 days after fertilization. With the advancement in embryo culturing technology, this ethical rule has been greatly challenged. In 2021, the International Society for Stem Cell Research (ISSCR) recommended a conditional extension of the existing time limit in ISSCR Guidelines for Stem Cell Research and Clinical Translation, hence the international scientific community has restarted the debate on the 14-day rule. This study systematically analyzed the historical background and controversies of the 14-day rule ethical regulation of …


Probe Into Mental Health Issues Caused By Major Natural Disasters And Crisis Interventions, Yankun Sun, Yimiao Gong, Xuebing Huang, Ying Qian, Siwei Sun, Hongguang Chen, Lin Lu Nov 2023

Probe Into Mental Health Issues Caused By Major Natural Disasters And Crisis Interventions, Yankun Sun, Yimiao Gong, Xuebing Huang, Ying Qian, Siwei Sun, Hongguang Chen, Lin Lu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Major natural disasters not only cause severe personnel casualties and social losses, but also bring long-lasting mental health issues related to psychological trauma. Timely and efficient post-disaster crisis interventions can avoid indelible psychological damages that disasters bring to populations such as survivors, victims’ families, witnesses, and rescuers. This article overviews the impact of major natural disasters on mental health and the characteristics of post-disaster psychological crisis. It also summarizes previous experience in post-disaster crisis interventions. In addition, it probes into future post-disaster crisis interventions, including improvement of the legal system for crisis intervention, clarification of the role of the government …


Interprofessional Education Among Health Care Professionals In The Care Of Autistic Children During The Last Two Decades (2001 To 2020): A Systematic Review Protocol, Sunitha Solomon Nagelli Ms., Sushmitha Karkada Dr., Ravishankar N Dr. Nov 2023

Interprofessional Education Among Health Care Professionals In The Care Of Autistic Children During The Last Two Decades (2001 To 2020): A Systematic Review Protocol, Sunitha Solomon Nagelli Ms., Sushmitha Karkada Dr., Ravishankar N Dr.

Manipal Journal of Nursing and Health Sciences

Introduction: Autism Spectrum Disorder requires management from multiple health professionals at various settings during the course of treatment. Interprofessional collaborative practice has been identified as one of the promising methods of care for an all-round healthcare management.

Objective: Collate empirical evidence on interprofessional education among healthcare professionals in providing care for children with autism

Method: Search will be conducted from five databases against the selected criteria. Review will be restricted to studies in English between 2001 to 2020 only. Two independent reviewers will scrutinize the abstract and title, and every study document retrieved will be investigated as …


Psychosocial Impacts On Parents Of Mentally Challenged Children At Mangaluru, Sooraj Kookal Mr Nov 2023

Psychosocial Impacts On Parents Of Mentally Challenged Children At Mangaluru, Sooraj Kookal Mr

Manipal Journal of Nursing and Health Sciences

Abstract

Introduction: Intellectually disabled children upset the mental, physical, social, and financial outlooks of the family in terms of their rearing and future. The support systems surrounding the parents of mentally retarded children play a vital role to lessen the burden associated with their special child. This study brings up some light on the psycho-social impacts on parents of Mentally challenged children who were attending special schools at Mangaluru. Objective: The main objective of the study was to assess the psychosocial impacts on parents of mentally challenged children. Further, to find the association between the psychosocial impact on …


Depression And Anxiety Of Care Partners During The Emergency Department Visit Of Older Adults With Cognitive Impairment, Nancy Glober, Anthony Perkins, Joshua Chodosh, Karen Connor, Sujuan Gao, Frank Messina, Malaz Boustani, Soo Borson, Nicole R. Fowler Nov 2023

Depression And Anxiety Of Care Partners During The Emergency Department Visit Of Older Adults With Cognitive Impairment, Nancy Glober, Anthony Perkins, Joshua Chodosh, Karen Connor, Sujuan Gao, Frank Messina, Malaz Boustani, Soo Borson, Nicole R. Fowler

Journal of Geriatric Emergency Medicine

Background: Older adults with cognitive impairment (CI) are more likely to visit the emergency department (ED) than those without CI. They are also more likely to suffer poor outcomes after an ED visit. Family and friends who serve as care partners contribute significant time and resources to the care of these patients and may need particular attention to their emotional needs during and after the ED encounter. In this study, we examined the association between patient and care partner characteristics on care partner depression and anxiety at the time of the ED visit.

Methods: Baseline data from 640 patient-care partner …


Targeting Loneliness In Older Adults With Weekly Socialization, Tanja Johnson Nov 2023

Targeting Loneliness In Older Adults With Weekly Socialization, Tanja Johnson

Dissertations

Problem: Loneliness related to social isolation among the older adult population has become an increasing health concern with few interventions available for the general population. Loneliness has been directly associated with depression, poorer physical health outcomes, and overall quality of life.

Methods: The purpose of this study is to evaluate loneliness in the older adult population residing in a senior living community in an urban area in Missouri. Weekly one-on-one socialization, ranging from 45-60 minutes, will be implemented over 6 weeks, with pre and post-intervention screening for loneliness with the 28-item Visit-A-Bit (VAB) screening tool. Approval was received by both …


Increase In Hnrnpa1 Expression Suffices To Kill Motor Neurons In Transgenic Rats, Xionghao Liu, Tingting Zhang, Qinxue Wu, Cao Huang, Xu-Gang Xia, Hongxia Zhou, Bo Huang Nov 2023

Increase In Hnrnpa1 Expression Suffices To Kill Motor Neurons In Transgenic Rats, Xionghao Liu, Tingting Zhang, Qinxue Wu, Cao Huang, Xu-Gang Xia, Hongxia Zhou, Bo Huang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

A dominant mutation in hnRNPA1 causes amyotrophic lateral sclerosis (ALS), but it is not known whether this mutation leads to motor neuron death through increased or decreased function. To elucidate the relationship between pathogenic hnRNPA1 mutation and its native function, we created novel transgenic rats that overexpressed wildtype rat hnRNPA1 exclusively in motor neurons. This targeted expression of wildtype hnRNPA1 caused severe motor neuron loss and subsequent denervation muscle atrophy in transgenic rats that recapitulated the characteristics of ALS. These findings demonstrate that the augmentation of hnRNPA1 expression suffices to trigger motor neuron degeneration and the manifestation of ALS-like phenotypes. …


Social Activity Restriction And Psychological Health Among Caregivers Of Older Adults With And Without Dementia, Elliane Irani, Kylie Meyer, Scott Emory Moore, Kedong Ding Nov 2023

Social Activity Restriction And Psychological Health Among Caregivers Of Older Adults With And Without Dementia, Elliane Irani, Kylie Meyer, Scott Emory Moore, Kedong Ding

Faculty Scholarship

Objectives: We examined associations between social activity restriction and psychological distress and well-being for caregivers of older adults with and without dementia, and if the identified associations are different for the two groups. Methods: Using data from the 2017 National Study of Caregiving, we identified caregivers of older adults with (N = 541) and without (N = 1701) dementia. Linear regression models were estimated, adjusting for caregivers’ age, gender, race, education, relationship to care recipient, and self-rated health. Results: Restriction in visiting friends and family and attending religious services were associated with higher distress in dementia caregivers. Restriction in visiting …


Designing For Community Engagement: User-Friendly Refugee Wellness Center Planning Process And Concept, A Health Design Case Study, Ellen Solomon, Brandon Joa, Shandon Coffman, Billie Faircloth, Marc Altshuler, Bon Ku Nov 2023

Designing For Community Engagement: User-Friendly Refugee Wellness Center Planning Process And Concept, A Health Design Case Study, Ellen Solomon, Brandon Joa, Shandon Coffman, Billie Faircloth, Marc Altshuler, Bon Ku

Department of Family & Community Medicine Faculty Papers

BACKGROUND: Refugee and immigrant populations have diverse cultural factors that affect their access to health care and must be considered when building a new clinical space. Health design thinking can help a clinical team evaluate and consolidate these factors while maintaining close contact with architects, patients' community leaders, and hospital or institutional leadership. A diverse group of clinicians, medical students, community leaders and architects planned a clinic devoted to refugee and immigrant health, a first-of-its-kind for South Philadelphia.

METHODS: The planning process and concept design of this wellness center is presented as a design case study to demonstrate how principles …


Risk And Protective Factors To Well-Being In Foster Care Youth Prescribed Psychotropic Medication In A Wraparound Program Of Care, Ann Reali Stratton Nov 2023

Risk And Protective Factors To Well-Being In Foster Care Youth Prescribed Psychotropic Medication In A Wraparound Program Of Care, Ann Reali Stratton

Dissertations

Background: Youth in foster care are prescribed psychotropic medications at higher rates and are more likely to experience disruptions to their medical care. Wraparound models of care have been shown to improve outcomes for youths on psychotropic medications, however, these methods have proved difficult to replicate in the foster care population. Government policies have called for better oversight in the foster care population and in response programs have been implemented, however, there remains little research for these programs. Objective: This research will evaluate the characteristics of foster care youth as they enter a Wraparound model of care and the predictive …