Digital Commons Network^™

Understanding Familicide: Psychosocial, Behavioral, And Mental Health Risk Factors And Implications For Forensic Behavioral Health Professionals, Molly M. Vogl

Master of Arts in Human Services

Familicide is a rare but devastating form of family violence involving the killing of multiple family members by another family member. Although research examining domestic violence, homicide, and homicide-suicide has expanded, familicide remains less understood due to its low occurrence and complex nature. This capstone examined the psychosocial, behavioral, and mental health risk factors commonly associated with familicide perpetrators and explored how forensic behavioral health professionals may use this information to improve violence risk assessment, prevention, and intervention efforts. A review of peer-reviewed research from academic databases and scholarly search engines identified common themes associated with familicide, including relationship conflict, …

Machine Learning For Functional Outcome Prediction After Vestibular Schwannoma Surgery: A Systematic Review And Diagnostic Test Accuracy Meta-Analysis, Shiva Nischal, Shaan Patel, Musa China, Kush Kale, Yi Hein Chai, Santosh Guru, William Muirhead, Patrick Grover

Department of Neurosurgery Faculty Papers

PURPOSE: Machine learning (ML) models have been increasingly applied to predict postoperative facial nerve dysfunction and hearing preservation after vestibular schwannoma (VS) surgery. However, reported performance varies substantially, and the overall diagnostic accuracy and clinical reliability of these models remain uncertain. We conducted a systematic review and diagnostic test accuracy meta-analysis to characterise the current state and methodological readiness of ML-based prediction of these outcomes.

METHODS: PubMed, Embase, and CENTRAL were searched from inception to February 2026. Studies evaluating ML-based prediction of facial nerve function or hearing preservation following VS surgery were included. Diagnostic performance metrics were pooled using random-effects …

Staff Education To Improve Healthcare Staff Knowledge Of An Electronic Scheduling System In An Intensive Outpatient Program (Iop), Catherine Kinyili

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice staff education project aimed to improve staff knowledge of the newly implemented electronic scheduling and booking kiosk system. A transition from a paper-based to an electronic scheduling system led to reduced staff efficiency, communication challenges, scheduling errors, and delays in patient care. An evaluation identified inconsistent staff knowledge of the newly implemented electronic scheduling system. The practice-focused question for the project was: Among healthcare staff in an intensive outpatient program, how does a one-time structured education and training session affect staff knowledge of a new electronic scheduling system? The purpose of this project was to …

The Experience Of Wellness And Self-Care For Graduating Bsn Students, Jenny Pappas, Terri A. Clark, Tasha Ruffin, Deborah Ellison, Adrienne Wilk, Debra Rose Wilson

Journal of Social, Behavioral, and Health Sciences

The aim of this study was to explore how graduating prelicensure bachelor of science in nursing (BSN) students experience self-care and wellness, with the goal of informing future curriculum development. Nursing students face significant academic, emotional, and sociocultural pressures that heighten vulnerability to burnout. Despite widespread agreement that self-care is a professional expectation, little is known about the students’ experience within demanding programs. Guided by Orem et al.’s (2001) self-care deficit theory, a qualitative study using interpretive hermeneutic phenomenology was used to examine lived experiences of self-care and wellness. Sixteen graduating BSN students participated in in-depth, semistructured interviews. Interviews were …

Redo-Transcatheter Aortic Valve Replacement With Self-Expanding Valves: A U.S. Registry Analysis., Toby Rogers, Vinayak N Bapat, Stanley J Chetcuti, Harold L Dauerman, John K Forrest, Sachin S Goel, Kendra J Grubb, Wah Wah Htun, Rishi Puri, Michael J Reardon, Gilbert H L Tang, Amit N Vora, Steven J Yakubov, Ruth Eisenberg, Guilherme F Attizzani

Heart and Vascular Articles

BACKGROUND: Redo-transcatheter aortic valve replacement (TAVR) for failed transcatheter heart valves is expected to increase, but data on outcomes with self-expanding valves remain limited.

OBJECTIVES: The aims of this study were to evaluate procedural, clinical, and quality-of-life outcomes following redo-TAVR using self-expanding Evolut valves and to compare these outcomes with those among a contemporary native TAVR cohort.

METHODS: Outcomes after redo-TAVR with Evolut R, Evolut PRO, and Evolut PRO+ valves in the Society of Thoracic Surgeons/American College of Cardiology TVT (Transcatheter Valve Therapy) Registry were analyzed and compared with outcomes after native-valve TAVR using the same valve platform during the …

Compbio And Miras-A Multi-Omic Analysis Platform Built On A Memory-Based Intelligence Engine, Ruteja A Barve, Chad E Storer, Wayne D Hoxsie, Curtis Marcum, Joshua F Mcmichael, Jared M Lalmansingh, Brittany K Smith, Mark R Johnson, Daniel J Kuster, Richard D Head

2020-Current year OA Pubs

As molecular and cellular technologies have advanced, the need to analyze and interpret the resulting vast and multi-modal data into actionable intelligence has become a rate-limiting factor in scientific advancement. While traditional knowledgebase-pathway tools and LLM-based AI tools provide a degree of support in data interpretation, both exhibit known limitations. Presented here is the CompBio multi-omic analysis platform built upon Memory-based Intelligent Reasoning System (MIRaS), an associative reasoning engine grounded in episodic and semantic memory, capable of inferring biological relationships directly from stored knowledge rather than from model training. The MIRaS system is not dependent on human-curated pathway knowledgebases, provides …

Wildfires And Adolescent Mental Health: A Call To Action, Troy Allan

All Current Publications

Although wildfires affect people across the lifespan, adolescents warrant focused attention because wildfires can disrupt several systems that are especially important during this developmental period, including family relationships, peer networks, schools, routines, housing stability, and a developing sense of safety and identity. This fact sheet provides an overview of current research and a practical response pathway for professionals and families.

Association Between Pain Catastrophising And Functional Limitation In Patients With Knee Osteoarthritis: A Cross-Sectional Study In A Tunisian Rehabilitation Setting, Soumaya Elarem, Ikram Haddada, Ameni Ameur, Ferdaous Blel, Nedra El Feni, Aymen Fekih, Aymen Haj Salah, Mouna Sghir, Wassia Kessomtini

Sultan Qaboos University Medical Journal

Objectives: Knee osteoarthritis (KOA) is a common reason for consultation in rehabilitation settings, responsible for pain and restricted autonomy. This study aimed to determine the association between catastrophising and functional limitation in patients followed for KOA in physical medicine and rehabilitation. Methods: This cross-sectional analytical study was conducted from June to August 2025 at the Department of Physical Medicine and Functional Rehabilitation in Taher Sfar University Hospital, Mahdia, Tunisia. Demographic data, the history of KOA as well as the radiographic stage of Kellgren and Lawrence were collected from patients with KOA. Functional impairment was assessed by the Lequesne knee index …

Intouch Week Of August 24, 2026, New York Medical College

InTouch

• Walking Tour of the William F. Bierer, M.D. ’62, Educational Medicinal Herbal Garden
• GSBMS Welcomes New Students During Welcome Luncheon
• New and Improved AEDs are Installed Across Campus
• New Partnership Opens Doors to Physical Therapy Careers for Westchester Students
• NYMC SOM Student Senate Hits the Ground Running with New Executive Board
• NYMC Faculty Mentor Future Dentists Through Immersive Summer Research Experience
• Inaugural Anesthesiology Summer Research Program Gives Students an Early Start in Academic Medicine
• TCDM Promotes Healthy Smiles in the Community
• Faculty Spotlight: 60 Seconds of Science | Episode 2: Cyclospora

New Frontiers In Diagnosing Equine Lameness, Hyrum Hoopes, Karl Hoopes

All Current Publications

Lameness is one of the most common and expensive health problems seen in horses. Modern technology allows veterinarians to look beneath the surface. Tools such as artificial intelligence (AI), computed tomography (CT), magnetic resonance imaging (MRI), digital radiography (X-rays), nuclear scintigraphy, ultrasound, and positron emission tomography (PET) give clearer, more detailed pictures of what’s happening inside the horse’s leg. Each technology offers different advantages, from identifying uneven movement to revealing hidden damage within bones, joints, or soft tissues. When combined with veterinary visual evaluation, they help pinpoint the cause of lameness faster and more accurately than ever before.

Mean Platelet Volume As A Marker Of Disease Severity In Hospitalized Children With Acute Bronchiolitis., Kedar Tilak, Trisha Sunderajan, Lewis Krata

Manuscripts, Articles, Book Chapters and Other Papers

Bronchiolitis is one of the most common lower respiratory tract infections affecting children less than two years of age and is a leading cause of hospitalization. Mean platelet volume (MPV), a readily available component of the complete blood count, has been investigated as an inflammatory biomarker in various conditions. Our present study evaluated the association between MPV values and the severity of acute bronchiolitis in hospitalized children.    Objective: The aim of this study was to determine the association between MPV, severity of respiratory distress, and need for oxygen support in hospitalized children under two years of age with acute bronchiolitis. …

Expanding Treatment Frontiers In Hidradenitis Suppurativa: Double Immunomodulator Therapy In Severe Refractory Cases, Christina Tolete, Adam Friedman, Teresa Duong, Leonardo Tjahjono

Student Papers, Posters & Projects

No abstract provided.

Interpretable Multimodal Learning For Integrating Neuroimaging And Genetic Data In Alzheimer’S Disease, Kun Zhao, Siyuan Dai, Yingying Zhang, Guodong Liu, Pengfei Gu, Chenghua Lin, Paul M. Thompson, Alex D. Leow, Heng Huang, Haoteng Tang

Computer Science Faculty Publications

Introduction: Early detection of Alzheimer's disease (AD) requires models that combine brain structure changes with genetic risk, but existing methods struggle to align these different data types.

Methods: We present R-GenIMA, an interpretable multimodal large language model that pairs a region-of-interest vision transformer with genetic prompting to jointly analyze structural MRI and single nucleotide polymorphisms (SNPs). Each brain region becomes a visual token and SNP profiles are encoded as structured text, letting the model link regional atrophy to genetic factors through cross-modal attention. Tested on the ADNI cohort, R-GenIMA performs well in classifying four groups: normal cognition, subjective memory concerns, …

A Four-Year Analysis Of #Orthotwitter Use During Match Week: Can X Be A Potential Equalizer For Students Left Unmatched?, Desiree E Ojo, Davis Hedbany, Brook Willett, Brandon D Rust, Geoffrey Deckard, Omar Guerrero, Jalen Warren, Michael Megafu, Morgan Turnow, Jaime Bellamy

Medical Education Articles

Background The orthopedic surgery match has changed. Since the COVID-19 pandemic, orthopedic surgery candidates and residency programs have used #Orthotwitter to promote, advocate, and educate their followers. This study aimed to evaluate changes in the use of #OrthoTwitter and #OrthoMatch during Match Week over a four-year period, including trends in author type, post content, institutional affiliation, engagement, and posting activity, with particular attention to posts involving unmatched applicants. Methodology The top tweets containing the hashtags #Orthotwitter and/or #OrthoMatch during the 2021, 2022, 2023, and 2024 Match Week were reviewed and collected. Tweets between the years 2021, 2022, 2023, and 2024 …

Act And Posttraumatic Growth In Military Veterans: Growth Through Flexibility After Adversity, Andrew J. Moller

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Military veterans are disproportionately exposed to potentially traumatic events across service eras. While much of the clinical and research literature has focused on posttraumatic stress disorder (PTSD) and symptom reduction, a growing body of work highlights the possibility of posttraumatic growth (PTG) following adversity. PTG refers to positive psychological changes that may emerge through engagement with traumatic experiences, including enhanced appreciation for life, renewed purpose, personal strength, deepened relationships, and reintegration into community roles. Importantly, PTG does not imply the absence of distress but may coexist alongside ongoing trauma-related symptoms. Understanding processes that facilitate growth alongside suffering may support more …

Identification, Validation, And Prediction Of Longitudinal Recovery Phenotypes In Degenerative Cervical Myelopathy: Analysis Of Prospective Cohorts And A Randomised Controlled Trial, Karlo Pedro, Mohammed Ali Alvi, Christopher Lozano, Vishwathsen Karthikeyan, Alex Bak, Benjamin Davies, James Harrop, Jetan Badhiwala, Jefferson Wilson, Wendy Lou, Zihang Lu, Kevin Thorpe, Michael Fehlings

Department of Neurosurgery Faculty Papers

BACKGROUND: Symptom evolution in degenerative cervical myelopathy (DCM) is traditionally characterized by severity of neurological deficit. A recent expert consensus challenged this view, proposing that DCM fluctuates across neurological, functional and health-related quality of life measures. We examined whether joint changes across these three domains define distinct recovery patterns in a clinic-based cohort of adult patients with DCM.

METHODS: Cohorts analysed were the Cervical Spondylotic Myelopathy-North America (CSM-NA, 2005-2007, N = 278), CSM-International (CSM-I, 2007-2011, N = 479) and the CSM-PROTECT Trial (2012-2017, N = 290). All participants were symptomatic adult DCM patients who underwent surgical treatment and completed at …

Norman H. Cromwell, Unl Chemistry; Nu System Dean; Eppley Cancer Center Director, Norman H. Cromwell, Pete Boughn, Mark A. Griep

UNL ORCA Interview Series

This 1980 interview of Normal Cromwell was done by Pete Boughn at the University of Nebraska Medical Center in Omaha. He asked about Cromwell’s history but mostly about his time as director of the Eppley Cancer Center. The interview is reproduced with permission from the UNMC McGoogan Library.

Cromwell was born in 1913 in Terre Haute, Indiana. In 1935, he earned a bachelor’s degree in chemical engineering from the Rose-Hulman Institute of Technology in his hometown. In 1939, three things happened: he earned a doctorate in organic chemistry from the University of Minnesota, he got married, and he was hired …

A Brief Self-Help Intervention For Anxiety And Depressive Symptoms Utilizing Cognitive Behavioral Therapy And Dialectical Behavior Therapy Within Correctional Settings, Genevieve L. Ray

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Individuals within incarcerated settings are far more likely to experience symptoms that meet criteria for a mental health disorder compared to the general population. This population is often underserved due to various financial and resource constraints. Self-help interventions have grown in popularity due to their proven effectiveness and accessibility for consumers, particularly for anxiety and depression symptoms. A self-help intervention for those in a correctional setting would not require extensive additional personnel amid financial constraints and would increase access to care. Many self-help interventions that are currently published apply to the community population, but readily accessible resources that reside in …

Well-Being Beyond The Binary In Perinatal Healthcare: An Application Of Reproductive Justice, Orphea D. Wright

Electronic Theses and Dissertations

Gender diverse birthing individuals face several systemic barriers to accessing affirming and empowering perinatal healthcare. The present study utilizes the term gender diverse and the abbreviation TGE to describe those who self-identify as broadly non-cisgender, an umbrella term for people whose gender identity differs from their sex assigned at birth. Gender identities that may be included in this definition include transgender/trans, gender expansive, non-binary, gender fluid, gender nonconforming, gender variant, gender queer/queer, and/or agender. Gender diverse individuals face unique barriers in perinatal healthcare due to the pervasiveness of cisnormativity in perinatal healthcare spaces. Research has documented the harm caused to …

Examining The Effects Of Perceived Need, Suicidal Ideation, And Interpersonal Shame On Help-Seeking Attitudes In Asian Pacific Islander Desi Americans, Kristen Jiin Park

Electronic Theses and Dissertations

This study examined relationships among suicidal ideation, perceived need for mental health services, interpersonal shame, and help-seeking attitudes in a sample of APIDA adults (N = 175). Guided by Andersen's Socio-behavioral Model of Help- Seeking Behaviors (1968) and the Interpersonal Shame Inventory framework (Wong et al., 2014), the study investigated whether interpersonal shame moderated the relationships between suicidal ideation and help-seeking attitudes, and between perceived need and help-seeking attitudes. Participants completed an online survey assessing demographic and study variables. Results indicated that perceived need and gender were associated with more favorable mental health help-seeking attitudes among APIDA adults. These findings …

Diagnosis And Treatment Of Trauma In Adolescents: A Doctoral-Level Clinical Psychology Course, Jasmine M. Cervantes

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Adolescent trauma is a significant mental health concern that can profoundly disrupt emotional, cognitive, social, and developmental functioning. Although evidence-based interventions for adolescent trauma are well established, doctoral-level psychology training programs may provide limited instruction focused specifically on the unique developmental, cultural, and clinical considerations required when treating traumatized adolescents. This paper presents the development of a ten-week doctoral-level elective course designed to address this gap in clinical training. The curriculum provides foundational knowledge regarding the prevalence, developmental impact, diagnosis, and treatment of adolescent trauma, with an emphasis on posttraumatic stress disorder (PTSD) and complex posttraumatic stress disorder (CPTSD). Students …

Sober Curious: A Treatment Manual For A Semi-Structured Interpersonal Process Group Targeting Substance Misuse In Emerging Adults, Annalise G. Floody

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

This paper presents Sober Curious, an original treatment manual for an eight-session, semi-structured interpersonal process group for emerging adults ages 18–25 with mild-to-moderate substance misuse concerns. This group is designed for university counseling centers and outpatient treatment settings, particularly for individuals who experience substance-related distress, impairment, risk, or ambivalence but may not identify with abstinence-based recovery or formal diagnostic substance use disorder (SUD) language. The manual is grounded in epidemiological data, established substance use treatment guidelines, meta-analytic findings on group psychotherapy and substance use interventions, and the developmental theory of emerging adulthood. Key intervention elements include motivational interviewing (MI) to …

Glucagon Like Peptide 1 Receptor Agonists In Patients With Inflammatory Bowel Disease: Safety, Clinical Effectiveness And Anti-Inflammatory Mechanisms, Shannon Fernando, Joy Zhao, Kevan Josloff, Nida Zubair, Aakash Desai, Raina Shivashankar, Patricia L. Kozuch, Cuckoo Choudhary, Gary Lichtenstein, Priya Sehgal

Division of Gastroenterology and Hepatology Faculty Papers

INTRODUCTION: The prevalence of obesity among patients with inflammatory bowel disease (IBD) continues to rise and is associated with adverse IBD outcomes and diminished treatment response. This study reviews the clinical safety and efficacy of glucagon-like peptide-1 receptor agonists (GLP-1RA) in patients with IBD and comorbid obesity and explores their theorized anti-inflammatory mechanisms.

METHODS: Published articles through July 2026 were identified via a PubMed search for a narrative review using terms related to GLP-1RA, IBD, safety, effectiveness, and outcomes. Data extraction focused on GLP-1RA intervention details, IBD-related outcomes and inflammatory markers, and proposed anti-inflammatory mechanisms.

RESULTS: GLP-1RA therapy promotes weight …

The Association Of Age, Race, And Gender And Novel Interventions In The Prevention Of Catheter-Associated Urinary Tract Infection, In Washington State, Lamin Darboe

Walden Dissertations and Doctoral Studies

Delayed removal of indwelling urinary catheters (IUCs) contributes to catheter-associated urinary tract infections, a leading healthcare-associated infection. A dot/smart-phrase communication tool, guided by the Health Belief Model construct of cues to action, to promote timely IUC removal interventions was evaluated in this quantitative, cross-sectional study. Secondary data from N = 372 adult patients with acute urinary retention in acute and critical care settings in Washington State were analyzed using SPSS Version 30. Binary logistic regression examined relationships among demographic variables, intervention-related factors (adherence within 48 hours, cosignature within 24 hours, and secure chat communication), and clinical outcomes (IUC removal and/or …

Early Immune Dysregulation In Mtb/Siv Co-Infection Resists Cart Treatment At The Single-Cell Level, Riti Sharan, Yi Zou, Zhao Lai, Korri Weldon, Todd Bradley, Xi Luo, Hulin Wu, Shabaana A Khader, Deepak Kaushal

Faculty, Staff and Student Publications

Using single-cell transcriptomics of bronchoalveolar lavage cells from Mtb/SIV co-infected rhesus macaques on cART, we reveal profound immune dysregulation during early SIV co-infection of latent tuberculosis. SIV induces a sharp decline in CD4+ T cells, NK, and NKT cells, with incomplete recovery of Mtb-specific TH1 effector responses despite viral suppression. Instead, a persistent TH17-skewed environment emerges, alongside sustained myeloid inflammation driven by Type I interferon signaling and pro-inflammatory regulators such as KLF6 and NFKB1. Ligand-receptor network analyses demonstrate expanded CD4+ T cell-macrophage crosstalk and loss of immune homeostasis that cART fails to fully restore. These findings expose …

Improving K-Card Observation Fidelity To Sustain A Culture Of Continuous Learning, John L. Ricks Iii

Master's Projects and Capstones

Problem

            Despite improvements in central line-associated bloodstream infection (CLABSI) attribution, variability in Kamishibai card (K-card) observation practices and documentation limited the unit's ability to identify, learn from, and correct persistent deviations from expected practice. Baseline data showed frequent incomplete documentation and a pattern of completing K-card observations outside bedside shift report.

Context

This project took place in a 20-bed medical-surgical ICU, using the existing K-card process to support high-reliability prevention of hospital-acquired conditions (HAC). Baseline assessment revealed inconsistent observation workflows, incomplete documentation, and unclear roles and expectations.

Interventions

A standardized K-card observation workflow was developed through rapid-cycle testing. Observations were …

Determinants Of Antenatal Care Utilization: A Community-Based, Cross-Sectional Study In Morang And Sunsari Districts, Eastern Nepal, Sunil Shah, Chandra Jha

Journal of Social, Behavioral, and Health Sciences

This study examined the factors influencing antenatal care (ANC) utilization in the eastern region of Nepal, focusing on the Morang and Sunsari districts, with the aim of identifying key determinants affecting ANC uptake and assessing the extent of ANC service utilization among mothers. Using lot quality assurance sampling, a community-based, descriptive, cross-sectional design was employed, surveying 164 mothers who had given birth within the previous 12 months; data were collected from June through November 2023. Data were collected through a semi-structured questionnaire and analyzed using SPSS, with descriptive statistics, chi-square tests, and logistic regression. Findings revealed that 80.5% of respondents …

Mechanism Of Injury And Fracture Status Influence Outcomes After Central Cord Injury, Karlo M. Pedro, Mohammed Ali Alvi, Kathleen Zang, Christopher Lozano, Jetan H. Badhiwala, Jefferson R. Wilson, James Harrop, James D. Guest, Bizhan Aarabi, Christopher I. Shaffrey, Michael G. Fehlings

Department of Neurosurgery Faculty Papers

Central cord syndrome (CCS) is the most common form of incomplete cervical spinal cord injury (SCI), yet its optimal management remains controversial. We examined whether stratifying CCS by injury stability improves treatment assessment. CCS was defined as an American Spinal Injury Association Impairment Scale (AIS) C/D cervical SCI with a ≥5-point lower-upper extremity motor score difference and classified as CCS-stable (CCS-S) or -unstable (CCS-U) based on the absence or presence of fracture/dislocation. Functional recovery at 1 year was assessed using the functional independence measure (FIM) motor score. Among 291 patients, 131 (45%) had CCS-S. These patients were older and more …

Panitumumab-Based Egfr Blockade In Smarcb1-Deficient Renal Medullary Carcinoma: Preclinical Basis And Prospective Clinical Activity, Niki M Zacharias, Eric S Rupe, Xinyue Chen, Ritesh R Kotecha, Damian T Rieke, Bradley A Mcgregor, Pedro Pesquera, Zhiyuan Yu, Abha Grover, Najat C Daw, Emily Wang, Sze Wah Samuel Chan, Dorothea Douglas-Lindsay, Alice C Fan, Eric M Knoche, Christos E Kyriakopoulos, Aly-Khan A Lalani, Charlene M Mantia, Amartej Merla, Martin H Voss, Nicklas Pfanzelter, Sneha Ramakrishna, Neil M Reaume, Tianyi Tang, Davis R Ingram, Diana Shamsutdinova, Khalida M Wani, Wei-Lien Wang, Alexander J Lazar, Rahul A Sheth, Priya Rao, Sandra L Grimm, Cristian Coarfa, Rong He, Jing Qian, Fei Duan, Deepa Bisht, Pankaj K Chauhan, Luigi Perelli, Giannicola Genovese, Liuqing Yang, Chunru Lin, Jose A Karam, Ludovica La Posta, Eleonora Dondossola, Rafet Basar, Nadima Uprety, Katayoun Rezvani, Jianjun Gao, Linghua Wang, Luisa M Solis Soto, Bora Lim, Nizar M Tannir, Menuka Karki, Pavlos Msaouel

Faculty, Staff and Students Publications

Purpose: SMARCB1-deficient renal medullary carcinoma (RMC) is an ultra-rare, lethal malignancy refractory to therapies approved for other renal cell carcinomas, and its rarity makes randomized trials logistically unfeasible. We investigated whether wild-type epidermal growth factor receptor (EGFR) is a therapeutically actionable dependency in RMC and translated this insight into a deployable clinical regimen.

Experimental design: EGFR expression was assessed by CLIA-certified immunohistochemistry in RMC tumors and by integrated RNA- and chromatin immunoprecipitation-sequencing of primary tumors and adjacent kidney. Panitumumab was compared with erlotinib in patient- and cell line-derived xenografts, and its mechanism defined by immunoblotting, confocal colocalization, cell-cycle and apoptosis …

The Effect Of Escape Room Simulation On The Self-Efficacy And Communication Levels Of Novice Critical Care Nurses, Lauren A. Femino, Kim Chapman, Julie A. Marshall, Shelby A. Trull, Jennifer A. Dibenedetto

The Lahey Journal

Abstract 

Introduction: Novice critical care nurses often report having low self-confidence and effective communication skills when transitioning to the ICU practice, often due to stress, limited experience, and unfamiliarity with critical care environments. These challenges can not only affect their job satisfaction and retention rates, but also pose serious risks to patient safety and outcomes. The purpose of this evidence-based practice (EBP) project was to assess the impact of an escape room simulation on the self-efficacy and communication skills of novice critical care nurses.

Methods: An evidence-based practice (EBP) project with pre-test and post-test design was conducted to …