Digital Commons Network^™

Fusobacterium Sphaericum Sp Nov, Isolated From A Human Colon Tumor Adheres To Colonic Epithelial Cells And Induces Il-8 Secretion, Martha A Zepeda-Rivera, Yannick Eisele, Alexander Baryiames, Hanrui Wu, Claudia Mengoni, Gianmarco Piccinno, Elsa F Mcmahon, Kaitlyn D Lacourse, Dakota S Jones, Hans Hauner, Samuel S Minot, Nicola Segata, Floyd E Dewhirst, Christopher D Johnston, Susan Bullman

Faculty, Staff and Student Publications

Cancerous tissue is a largely unexplored microbial niche that provides a unique environment for the colonization and growth of specific bacterial communities, and with it, the opportunity to identify novel bacterial species. Here, we report distinct features of a novel Fusobacterium species, F. sphaericum sp. nov. (Fs), isolated from primary colon adenocarcinoma tissue. We acquire the complete closed genome and associated methylome of this organism and phylogenetically confirm its classification into the Fusobacterium genus, with F. perfoetens as its closest neighbor. Fs is phenotypically and genetically distinct, with morphological analysis revealing its coccoid shape, that while similar to …

December 2025, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

• SWOSU Wellness 5k
• Employee Massages 12/4 & 12/5
• Flu Season
• Winter Crossword

Income Inequality And Self-Reported Health: A Difference-In-Differences Study, Kola Adegoke

Health & Biomedical Sciences Faculty Publications

Background: Health disparities in the United States (US) are closely linked to income inequality. While many studies have reported associations between income and health, causal evidence remains limited.

Objective: To estimate the causal effect of income-equalizing state policies, such as minimum wage increases, Medicaid expansion, and Earned Income Tax Credit (EITC) adjustments, on adult self-rated health using a difference-in-differences (DiD) framework.

Methods: Using the Centers for Disease Control and Prevention (CDC) Behavioral Risk Factor Surveillance System (BRFSS) data from 2018 to 2023, a 2-way fixed-effects DiD model was employed to compare changes in the proportion of adults reporting fair or …

From Awareness To Action: Improving Advanced Directives With The Five Wishes In College Aged Young Adults, Dina M. Giovanetti

Electronic Theses and Dissertations 2020 - Present

This quality improvement project aimed to increase early education, initiation, documentation, and completion rates of advance directives (ADs), specifically the Five Wishes, among college-aged young adults (18–24 years old) in a concierge primary care setting. The project addressed the low engagement and completion rates of ADs in this population, which can result in inadequate end-of-life care planning. The initiative involved training all staff members through collaborative instruction, informational sessions, and personalized provider-patient discussions. A convenience sample of eligible patients was identified via chart review. Inclusion criteria included English-speaking young adults aged 18–24, regardless of comorbid conditions who were members of …

Real-World Disease Burden And Health Care Resource Utilization For Patients With Barth Syndrome, Lindsay Marjoram, Yonglin Huang, Mary Kay Koenig, Bruce H Cohen, Eric Anderson

Faculty, Staff and Student Publications

Background: Barth syndrome (BTHS) is an ultra-rare, X-linked genetic disorder for which there is limited economic data. Because compiling such data that target rare indications is difficult, we assessed real-world data to increase understanding of the cost of BTHS based on disease burden and health care resource utilization (HCRU).

Methods: A search of the published medical literature identified individual case studies and registry data used to assess the burden of disease and potential costs associated with BTHS, including the potential ability of developing treatments to positively impact those costs. In addition, a claims database analysis was conducted to assess HCRU …

Health Outcomes Of Sarcopenia: A Consensus Report By The Outcome Working Group Of The Global Leadership Initiative In Sarcopenia (Glis), Charlotte Beaudart, Julian Alcazar, Ivan Aprahamian, John A. Batsis, Yosuke Yamada, Carla M. Prado, Jean Yves Reginster, Dolores Sanchez-Rodriguez, Wee Shiong Lim, Marc Sim, Stephan Von Haehling, Jean Woo, Gustavo Duque

Research outputs 2022 to 2026

The Global Leadership Initiative in Sarcopenia (GLIS) aims to standardize the definition and diagnostic criteria for sarcopenia into one unifying, common classification. Among other actions to achieve this objective, the GLIS has organized three different working groups (WGs), with the WG on outcomes of sarcopenia focusing on reporting its health outcomes to be measured in clinical practice once a diagnosis has been established. This includes sarcopenia definitions that better predict health outcomes, the preferred tools for measuring these outcomes, and the cutoffs defining normal and abnormal values. The present article synthesizes discussions and conclusions from this WG, composed of 13 …

Feasibility Of A Co-Designed And Personalised Intervention To Improve Vegetable Intake In Rural-Dwelling Young Adults, Katherine Mary Livingstone, Jonathan C. Rawstorn, Stephanie R. Partridge, Yuxin Zhang, Eric O, Stephanie L. Godrich, Sarah A. Mcnaughton, Gilly A. Hendrie, Kathleen M. Dullaghan, Gavin Abbott, Lauren C. Blekkenhorst, Ralph Maddison, Scott Barnett, John C. Mathers, Laura Alston

Research outputs 2022 to 2026

Background: This study determined the feasibility, acceptability, engagement and efficacy of a co-designed and personalised digital intervention to increase vegetable intake (Veg4Me) in young (18-to-35 years) rural-dwelling Australian adults. Methods: Participants living in rural Australia were recruited via local government networks and social media and randomised to receive 12-weeks’ access to personalised (intervention) or non-personalised (control) versions of the free Veg4Me web application. The intervention included: (1) personalised recipes, (2) geo-located food environment map, (3) healthy eating resources, (4) goal-setting portal, and (5) personalised e-newsletters. The primary outcome was feasibility (recruitment, participation, and retention rate). Secondary outcomes were user engagement, …

What Are The Optimal Transcranial Direct Current Stimulation Parameters And Design Elements To Modulate Corticospinal Excitability? A Systematic Review And Longitudinal Meta-Analysis, Liam C. Tapsell, Matheus D. Pinto, Ann Maree Vallence, Casey Whife, Maria Luciana Perez Armendariz, Shaswat Senger, Jack Andringa-Bate, Dana Hince, Myles C. Murphy

Research outputs 2022 to 2026

Background: Corticospinal excitability, measured by motor-evoked potentials (MEPs), is often impaired in neurological and musculoskeletal conditions. Transcranial direct current stimulation (tDCS) can modulate cortical excitability and improve clinical outcomes, yet inconsistencies in parameter settings complicate identification of optimal protocols. Objective: Our primary objective was to examine the effects of: (i) stimulation polarity, (ii) duration, (iii) intensity, (iv) frequency, (v) electrode montage, and (vi) electrode design (size/shape) on MEP size. Methods: Nine databases were searched from inception to 24th November 2023. We identified 84 individual cohorts (1,709 participants) and assessed time-dependent effects of each parameter on M1 MEP-to-baseline ratio in healthy …

Live High-Train Low Induced Changes In Hemoglobin Mass And The Erythropoietin-Erythroferrone-Hepcidin Axis In Female Endurance Athletes, Titta Kuorelahti, Johanna K. Ihalainen, Vesa Linnamo, Claire Badenhorst, Oona Kettunen, Ritva Mikkonen

Research outputs 2022 to 2026

The effects of a 21-day live high-train low (LHTL) on hemoglobin mass (Hbmass) and iron demand including the erythropoietin (EPO)-erythroferrone (ERFE)-hepcidin axis and routine iron markers were investigated. Fifteen female endurance athletes completed either 21-day LHTL in normobaric hypoxia (2500 m, ~18 h·day⁻¹) (INT, n = 8) or lived and trained in normoxia (CON, n = 7). Hbmass and resting blood were collected before and after the intervention. An additional blood sample was collected on Day 6 for INT. 21-day LHTL increased Hbmass 3.8% in INT (p < 0.001). EPO increased 35.6% from Day 0 to Day 6 in INT (p = 0.037) and then decreased 42.4% from Day 6 to Day 21 (p = 0.019). In INT, no changes were detected in ERFE or hepcidin, and from the routine iron markers only serum transferrin receptor increased from Day 0 to Day 21 (13.9%, p = 0.013). In CON, no changes were detected in Hbmass or iron markers. In INT, Hbmass and ferritin were positively associated (Day 0 to Day 6, p = 0.005). Thus, hepcidin and ERFE may not provide additional information regarding iron demand following 6- or 21-day LHTL compared to routine iron markers. The relationship between Hbmass and ferritin indicates that adequate ferritin levels are needed during hypoxia to support hematological adaptations.

Periodizing Exercise Medicine Prescription For Patients With Cancer: A Narrative Opinion, Francesco Bettariga, Robert U. Newton, Chris Bishop, Luca Maestroni, Anita Borsati, Alice Avancini, Sara Pilotto, Dennis R. Taaffe, Daniel A. Galvão, G. Gregory Haff

Research outputs 2022 to 2026

Exercise has emerged as an effective therapeutic strategy in cancer management. Long-term supervised exercise programs, including resistance training and aerobic training, can improve body composition and physical fitness, modulate circulating factors (e.g., hormones, cytokines), enhance treatment tolerance, and reduce side effects, potentially influencing cancer progression and reducing mortality risk. Despite advancements in exercise oncology, opportunities remain to refine exercise prescription through the integration of advanced methodologies such as periodization and autoregulatory programming strategies. Periodization, a systematic approach to organizing training over time, has demonstrated benefits in general fitness and clinical populations but is underexplored in cancer care. Emerging evidence suggests …

Rac1 In Gastric Cancer: A Molecular Driver Of Invasion, Emt, And Therapeutic Resistance, Jianwen Li, Yahong Zhu, Ruifeng Duan, Yueli Tian, Xingang Li, Ying Song

Research outputs 2022 to 2026

Gastric cancer (GC) ranks as the fifth most common cancer worldwide and is the third main cause of cancer-related mortality, posing a substantial burden to global public health. Research suggests that targeted therapy and immunotherapy may become more effective treatment options for advanced, unresectable, or metastatic gastric cancer. Ras-related C3 botulinum toxin substrate 1 (Rac1), a small GTP-binding protein within the Rac subfamily of the Rho GTPase family, is a critical molecule that promotes cancer cell invasion and metastasis by regulating signal transmission and promoting cell polarity. It has emerged as a key driver of tumor development and metastasis in …

Relationships Of Upper Respiratory Tract Infections And Holistic Diets And Lifestyles In Northeast China, Hongmei Wang, Khui Hung Lee, Shaoxiao Qin, Kan Yu, Shaoying Hou, Kaihong Tang, Jiabao Liu, Yingyu Jin, Zhuo Shang, Deyu Dai

Research outputs 2022 to 2026

Background: Upper respiratory tract infections (URTIs) are prevalent public health issues worldwide. Their prevention is challenging, and they pose a significant economic burden due to their susceptibility to secondary infections and lack of effective treatments. This study investigates the relationship between URTIs and the holistic diets and lifestyles of residents in Northeast China. Methods: A cross-sectional study was conducted using data from 4058 participants aged 12 to 70 who participated in the Internet-based dietary questionnaire for Chinese (IDQC), collected between 2012 and 2019. Statistical analyses were performed with SPSS 20.0 software, employing chi-square tests for categorical data and Kruskal-Wallis tests …

Practical Recommendations On Stretching Exercise: A Delphi Consensus Statement Of International Research Experts, Konstantin Warneke, Ewan Thomas, Anthony J. Blazevich, José Afonso, David G. Behm, Paulo H. Marchetti, Gabriel S. Trajano, Masatoshi Nakamura, Francisco Ayala, Stefano Longo, Nicolas Babault, Sandro R. Freitas, Pablo B. Costa, Andreas Konrad, Antoine Nordez, Arnold Nelson, Astrid Zech, Anthony D. Kay, Olyvia Donti, Jan Wilke

Research outputs 2022 to 2026

Background: Stretching has wide appeal, but there seems to exist some mismatch between its purported applications and what the evidence shows. There is compelling evidence for some stretching applications, but for others, the evidence seems heterogeneous or unsupportive. The discrepancies even affect some systematic reviews, possibly due to heterogeneous eligibility criteria and search strategies. This consensus paper seeks to unify the divergent findings on stretching and its implications for both athletic performance and clinical practices by delivering evidence-based recommendations. Methods: A panel of 20 experts with a blend of practical experience and scholarly knowledge was assembled. The panel meticulously reviewed …

Prevalence And Trends Of Coexisting Forms Of Malnutrition And Its Associated Factors Among Children Aged 6–59 Months In South And Southeast Asia, 1996–2022: A Cross-Sectional Time Series Study, Wenjie Guo, Maggie Zgambo, Sanmei Chen, Yoko Shimpuku

Research outputs 2022 to 2026

Background: South and Southeast Asia face severe malnutrition in children under five, with coexisting forms of malnutrition (CFM) exacerbating mortality risks and posing greater challenges than isolated forms of malnutrition. We aimed to assess the prevalence, trends, and factors of CFM among children aged 6–59 months in South and Southeast Asian countries and the entire region. Methods: We used anthropometric and hemoglobin data from 515,170 children aged 6–59 months in seven low- and middle-income South and Southeast Asian countries, based on Demographic and Health Surveys conducted between 1996 and 2022. Weighted multivariable logistic regression was performed to identify the sociodemographic …

Echoes Of The Modern Training Periodization Concepts In Russia Before The October 1917 Revolution, Sandro Bartolomei, Gulnara Mammadova, Renato Manno, Gregory G. Haff, Jay R. Hoffman, Franco Merni

Research outputs 2022 to 2026

Abstract – Bartolomei, S, Mammadova, G, Manno, R, Haff, GG, Hoffman, JR, and Merni, F. Echoes of the modern training periodization concepts in Russia before the October 1917 revolution. J Strength Cond Res 39(12): 1327–1330, 2025—The debate on the origins of the discipline of training periodization is still ongoing. The text “Olympic Sport, ” published by B. A. Kotov in 1916, was one of the first known books to focus on training methods and strategies for performance development. The book is also considered the first to deal with training organization and periodization. In addition, Kotov was the only author to …

Exercise For Postmenopausal Bone Health – Can We Raise The Bar?, Shejil Kumar, Cassandra Smith, Roderick J. Clifton-Bligh, Belinda R. Beck, Christian M. Girgis

Research outputs 2022 to 2026

Purpose of Review: This review summarises the latest evidence on effects of exercise on falls prevention, bone mineral density (BMD) and fragility fracture risk in postmenopausal women, explores hypotheses underpinning exercise-mediated effects on BMD and sheds light on innovative concepts to better understand and harness the skeletal benefits of exercise. Recent Findings: Multimodal exercise programs incorporating challenging balance exercises can prevent falls. Emerging clinical trial evidence indicates supervised progressive high-intensity resistance and impact training (HiRIT) is efficacious in increasing lumbar spine BMD and is safe and well-tolerated in postmenopausal women with osteoporosis/osteopenia. There remains uncertainty regarding durability of this load-induced …

Trajectories Of Plant-Based Dietary Patterns And Their Sex-Specific Associations With Cardiometabolic Health Among Young Australian Adults, Laura E. Marchese, Sarah A. Mcnaughton, Gilly A. Hendrie, Priscila P. Machado, Therese A. O’Sullivan, Lawrence J. Beilin, Trevor A. Mori, Kacie M. Dickinson, Katherine M. Livingstone

Research outputs 2022 to 2026

Background: Plant-based diets are associated with favourable cardiovascular health markers. Although increasingly consumed among younger demographics, it is unclear how plant-based diet quality tracks from adolescence to young adulthood, and how this impacts cardiovascular health later in life. Thus, this study aimed to explore trajectories of plant-based dietary patterns from adolescence to young adulthood and investigate associations with cardiometabolic health markers in young Australian adults. Methods: Longitudinal data from 417 participants from the Raine Study were included. Semi-quantitative food frequency questionnaires conducted at 14, 20, and 27 years of were used to derive three plant-based diet quality index scores: an …

Interpretive Prediction Of Hyperuricemia And Gout Patients Via Machine Learning Analysis Of Human Gut Microbiome, Jia Wei Tang, Alfred Chin Yen Tay, Liang Wang

Research outputs 2022 to 2026

Hyperuricemia (HUA) and gout result from imbalances in uric acid metabolism and are closely associated with the gut microbiota. Advanced analytical methods facilitate the exploration of microbiota complexity. In this study, 16S rRNA sequencing data from stool samples of 233 patients were thoroughly collected. Machine learning (ML) and Shapley Additive exPlanations (SHAP) interpretability algorithms were applied to identify core taxa and predict the metabolic functions. The results revealed that the high-contribution core taxa identified by SHAP in each group, such as Oscillospiraceae_UCG-005 and Rhodococcus provided the basis for ML prediction. Among the five classification models, Random Forest (RF) achieved the …

Cognitive Frailty And Cardiometabolic Risk In Middle-Aged And Older Adults: Evidence From The Uk And China, Haiyang Yan, Jingjing Lang, Chengfeng Li, Samaneh Eftekhariranjbar, Guoyan Jiang, Jing Lei, Lixin Sun, Carlos J. Toro-Huamanchumo, Zhongyang Guan

Research outputs 2022 to 2026

Background: Cognitive frailty, a novel construct integrating cognitive and physical deficits, is increasingly recognized in aging research. Aims: This study aimed to examine the associations between cognitive frailty and cardiometabolic risk in two nationally representative cohorts from China and the United Kingdom. Methods: We analyzed data from 7,628 participants in the China Health and Retirement Longitudinal Study (CHARLS) and 4,703 participants from the English Longitudinal Study of Ageing (ELSA), all aged ≥ 50 years. Frailty was assessed using the frailty index (FI) in the main analysis. Cox proportional hazards models were applied to estimate hazard ratios (HRs) for incident cardiometabolic …

High-Dose Beta-Alanine Supplementation For Two Weeks Did Not Enhance Intermittent Endurance Or Sprint Performance In Trained Futsal Players, Hossein Miraftabi, Erfan Berjisian, Marzieh Nouri Dizicheh, Alireza Naderi, Masoud Bodaghi, Majid S. Koozehchian, Fatemeh Shabkhiz, Alvaro Lopez-Samanes

Research outputs 2022 to 2026

Background: This study aimed to investigate the effects of a high-dose beta-alanine (BA) supplementation on physical performance, blood lactate concentration, and ratings of perceived exertion (RPE) in trained futsal players. Methods: Sixteen trained futsal players participated in a randomized, parallel, double-blind experiment, completing a two-week supplementation period with either 12 g/day of BA (n = 8; age: 19 ± 2 years; height: 1.78 ± 0.03 m; body mass: 68.5 ± 5.4 kg) or a placebo (PLA) (n = 8; age: 18 ± 1 years; height: 1.74 ± 0.08 m; body mass: 65.6 ± 6.4 kg). Athletes completed the futsal intermittent …

Neutrophil Gelatinase-Associated Lipocalin And Fibrinogen-To-Albumin Ratio Are Indicators Of Kidney Disease In Sickle Cell Disease Patients With Microalbuminuria: A Multicentre Case-Control Study In Ghana, Stephen Twumasi, Enoch Odame Anto, Christian Obirikorang, Richard Kobina Dadzie Ephraim, Benedict Sackey, Vivian Paintsil, Richard Owusu Ansah, Alfred Effah, Allwell Adofo Ayirebi, Angela Opoku, Godfred Yawson Scott, Leslie Osei, Joyce Duku, Emmanuel Asafo Adjei, Lilian Antwi Boateng

Research outputs 2022 to 2026

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is present in secondary granules of neutrophils and it is a relatively newly recognized marker of kidney diseases. The fibrinogen-to-albumin ratio (FAR) is a marker of inflammation but its diagnostic value has not been determined in sickle cell disease patients with kidney diseases. This study investigated the diagnostic roles of serum neutrophil gelatinase-associated lipocalin (sNGAL) and FAR for kidney diseases in steady-state adult sickle cell disease (SCD) patients. Methods: This study employed a prospective case-control design and recruited 104 SCD participants and 80 non-SCD patients. Participants’ information was thoroughly documented using a structured questionnaire and …

Voluntary Activation Of The Ankle Plantar Flexors: A Systematic Review And Meta-Analysis, Molly E. Coventry, Christopher Latella, Brady Green, Andrea B. Mosler, Jayden Peak, Maria Luciana Perez Armendariz, Ebonie K. Rio, Myles C. Murphy

Research outputs 2022 to 2026

Background: Voluntary activation is a measure of neural drive, typically measured during maximal contractions, and provides insight into motor function. This systematic review examined voluntary activation assessment of the ankle plantar flexors in healthy and pathological populations, and the association of participant age and positioning (knee and ankle joint angles) with voluntary activation level. Methods: A systematic review and meta-analyses were conducted. Six electronic databases were systematically searched for studies that assessed voluntary activation of the ankle plantar flexors using the interpolated twitch technique or the central activation ratio. Meta-analyses were performed using an inverse variance, random-effects maximal likelihood model …

Is Maternal Diabetes During Pregnancy Associated With Neurodevelopmental, Cognitive And Behavioural Outcomes In Children? Insights From Individual Participant Data Meta-Analysis In Ten Birth Cohorts, Rachelle A. Pretorius, Demetris Avraam, Mònica Guxens, Jordi Julvez, Jennifer R. Harris, Johanna Thorbjornsrud Nader, Tim Cadman, Ahmed Elhakeem, Katrine Strandberg-Larsen, Hanan El Marroun, Serena Defina, Tiffany C. Yang, Rosie Mceachan, John Wright, Jesús Ibarluzea, Loreto Santa-Marina, Juana Mari Delgado, Marisa Rebagliato, Marie Aline Charles, Chloe Vainqueur, Silvia Maritano, Daniela Zugna, Wen Lun Yuan, Barbara Heude, Rae Chi Huang

Research outputs 2022 to 2026

Background: Growing evidence shows that dysregulated metabolic intrauterine environments can affect offspring’s neurodevelopment and behaviour. However, the results of individual cohort studies have been inconsistent. We aimed to investigate the association between maternal diabetes before pregnancy and gestational diabetes mellitus (GDM) with neurodevelopmental, cognitive and behavioural outcomes in children. Methods: Harmonised data from > 200 000 mother-child pairs across ten birth cohorts in Europe and Australia were available. Mother-child pairs were included for analysis to determine whether GDM was recorded (yes or no) and whether at least one neurodevelopmental, cognitive and behavioural outcome was available in children aged 3 to 13 …

The Effect Of Prednisolone Ingestion And Acute Exercise On Lipocalin-2 And Its Variants In Young Men: A Pilot Randomised Crossover Study, Carlie Bauer, Rhiannon K. Patten, Qiyang Sun, Haoyun Li, Daniels Konja, Mary Woessner, Xuzhu Lin, Andrew Garnham, David L. Hare, Peter R. Ebeling, Marc Sim, Joshua R. Lewis, Yu Wang, Lewan Parker, Itamar Levinger

Research outputs 2022 to 2026

Lipocalin-2 (LCN2) has three main variants; polyaminated (hLCN2) and non-polyaminated (C87A and R81E). The polyaminated form is proposed to positively influence energy control, whereas the non-polyaminated forms negatively impact energy control in mice. Glucocorticoids negatively affect glucose regulation and exercise has a positive effect. We hypothesise that glucocorticoids will suppress, while exercise will increase hLCN2, and decrease C87A and R81E, which will be associated with improved insulin sensitivity. In a randomised crossover design, nine young healthy men (aged 27.8 ± 4.9 years; BMI 24.4 ± 2.4 kg/m2) completed 30 min of high-intensity aerobic exercise (90–95% heart rate reserve) after glucocorticoid …

Impact Of Peripheral Circadian Misalignment And Alcohol On The Resiliency Of Intestinal Barrier And Microbiota, Laura Tran, Maliha Shaikh, Phillip A Engen, Ankur Naqib, Dulce M Frausto, Vivian Ramirez, Malia Gasteier, Zlata Bogin, Kristi Lawrence, Lijuan Zhang, Shiwen Song, Stefan J Green, Faraz Bishehsari, Christopher B Forsyth, Ali Keshavarzian, Garth R Swanson

Faculty, Staff and Student Publications

Circadian organization is involved in many gastrointestinal tract (GIT) functions such as the maintenance of intestinal barrier integrity. There is compelling evidence that perturbation of the circadian clock decreases intestinal epithelial cells' resiliency to alcohol-induced injury. One of the most common causes of circadian misalignment is wrong-time eating (largest meal at dinner) in modern societies. Yet, few studies have examined the importance of peripheral circadian rhythms of the GIT to alcohol consumption. Eating patterns during physiologic rest time, defined as wrong-time eating (WTE), misalign the peripheral circadian clock of the GIT and the body's central clock. This study aims to …

Genetic Predisposition To Persistent Fatigue After A Diagnosis Of Colorectal Cancer, Elham Kazemian, Adetunji T Toriola, Et Al.

2020-Current year OA Pubs

BACKGROUND: Cancer-related fatigue (fatigue) is a common and persistent symptom after cancer treatment, yet the role of genetic susceptibility remains unclear.

METHODS: We used data from a prospective cohort study called the ColoCare Study, conducted over 5 US sites and Germany. Fatigue was assessed at 5 time points using the European Organisation for the Research and Treatment of Cancer Core Quality of Life Questionnaire fatigue subscale and analyzed as (1) a binary summary measure of the trajectory from diagnosis into survivorship (defined as severe: yes/no), (2) a mean score across all time points, and (3) the highest (ie, worst) score …

Early Life Infection With Cryptosporidium Parvum Induces Inflammatory Responses To Dietary Antigens, Iti Saraav, Wanyi Huang, Jisun Jung, Rui Xu, Yong Fu, Keely Mcdonald, Lawrence A Schriefer, Rachel Rodgers, Megan T Baldridge, Rodney D Newberry, Chyi-Song Hsieh, L David Sibley

2020-Current year OA Pubs

To examine the effect of early-life infection with

Knowledge Mapping And Visualized Analysis Of Research Progress In Onconephrology: A Bibliometric Analysis, Yiwei Wang, Shuling Fan, Wei Wang

Faculty, Staff and Student Publications

Objectives: Onconephrology is an expanding subspecialty focused on the management of cancer patients with renal injury. This study used a comprehensive bibliometric analysis to emphasize the need for cooperation between oncologists and nephrologists, exploring current trends and future research areas in onconephrology.

Methods: Relevant literature on onconephrology published between 1 January 2000 and 27 April 2024 was retrieved from the Science Citation Index Expanded of the Web of Science Core Collection, followed by manual screening. Bibliometric analyses were performed using CiteSpace, VOSviewer, and Bibliometrix software.

Results: A total of 1,853 publications, including 1,647 articles and 206 reviews, by 11,606 authors …

Glp-1 Medications For Kids: Do They Work, And At What Price?, Sylvia Peña, Marilyn Frenn

College of Nursing Faculty Research and Publications

Context

Childhood obesity continues to increase along with the numbers of children with severe obesity and related comorbidities. This meta-analysis1 sought to determine whether or not glucagon-like peptide-1 receptor agonist (GLP-1 RA) medications are safe and effective for children and adolescents.

Methods

Appropriate search and abstraction approaches were used in the meta-analysis of randomised controlled trials making it the highest level of evidence. Included studies were those with participants younger than 18 years with obesity, overweight, pre-diabetes or type 2 diabetes (T2D) assessing GLP-1 RAs alone or with lifestyle modification versus placebo published between 2023 and 2025. Most participants …

Effects Of Exercise Or Diet Or Combined Interventions On Treatment Efficacy Of Chemotherapy For Cancer: A Systematic Review, Cristina Crespo-Garcia, Francesco Bettariga, Dennis R. Taaffe, Carolyn J. Peddle-Mcintyre, John P. Campbell, Emily Jeffery, Anna Maria Markarian, Anita Borsati, Alice Avancini, Sara Pilotto, Daniel A. Galvao, Robert U. Newton

Research outputs 2022 to 2026

Purpose of Review: While exercise and dietary interventions in patients with cancer undergoing chemotherapy have been demonstrated to be safe and feasible and improve patient-reported outcomes, the effects on treatment efficacy have not been widely examined and remain unclear. This review aimed to examine the effects of exercise, dietary, and combined interventions on tumour response and time-to-event outcomes in patients with cancer undergoing chemotherapy. Recent Findings: A systematic review of intervention studies was conducted based on PRISMA guidelines Databases searched were PubMed, Medline, CINAHL, Embase, and Web of Science. Methodological quality and risk of bias were assessed using the RoB2 …