Digital Commons Network^™

Inter-Rater Reliability Of Manual Waist Circumference And Agreement With Dxa-Derived Waist In Male Collegiate Rugby Players, Hayden Johnson, Christian Rivera, Stephanie Hansford, Regan Renfro, Dalton Prye, Matthew Poole, Saheed Jaiyeola, Sage A. Newman, Adesiji Adetona, Oscar Woodside, Jmya Hughes, Preston James, Kelly Hines, Jade Simon, Drew E. Gonzalez, Christopher D. Greenleaf, Micheil Spillane

International Journal of Exercise Science: Conference Proceedings

Waist circumference (WC) is a low-cost surrogate of central adiposity, but measurement error can limit athlete monitoring. PURPOSE: Evaluate inter-rater reliability of manual WC and agreement with dual-energy X-ray absorptiometry (DXA)-derived WC in male collegiate rugby players. METHODS: Twenty-one male collegiate rugby players completed baseline testing (manual WC and DXA completed same day) following an overnight fast and euhydration. Two trained raters independently measured WC on bare skin at the superior border of the iliac crest (site not pre-marked) using a seca 201 measurement tape, with participants standing feet together and arms relaxed at their sides; the tape was verified …

Associations Between Dxa-Derived Trunk Adiposity And Resting Hemodynamics In Male Collegiate Rugby Union Athletes, Adesiji Adetona, Hayden Johnson, Christian Rivera, Stephanie Hansford, Regan Renfro, Dalton Prye, Matthew Poole, Saheed Jaiyeola, Sage A. Newman, Oscar Woodside, Jmya Hughes, Preston James, Kelly Hines, Jade Simon, Drew E. Gonzalez, Christopher D. Greenleaf, Micheil Spillane

International Journal of Exercise Science: Conference Proceedings

Trunk adiposity is a cardiometabolic risk factor that may relate to resting hemodynamics even in young athletic populations. PURPOSE: To examine associations between DXA-derived trunk percent fat and resting heart rate (HR) and blood pressure (BP) in male collegiate rugby union athletes. METHODS: Twenty-one male rugby athletes completed morning testing (06:00–09:00 h) following ≥12 h fast and post-void, with stimulants (including caffeine) restricted ≥12 h and no exercise ≥24 h. Hydration was screened using urine specific gravity (USG; CLINITEK Status+ with Multistix 10 SG) and urine color (clear yellow). Whole-body DXA (Hologic Horizon W; APEX v5.6.1.3 rev 007) provided trunk …

Comparison Of Dxa-Derived Body Volume Estimation Equations (Wilson Vs Smith-Ryan) In Collegiate Rugby Union Athletes, Jmya Hughes, Hayden Johnson, Christian Rivera, Stephanie Hansford, Regan Renfro, Dalton Prye, Matthew Poole, Saheed Jaiyeola, Sage A. Newman, Adesiji Adetona, Oscar Woodside, Preston James, Kelly Hines, Jade Simon, Drew E. Gonzalez, Christopher D. Greenleaf, Micheil Spillane

International Journal of Exercise Science: Conference Proceedings

Accurate estimation of body volume (BV) is required for multicomponent body composition models. PURPOSE: Compare two published DXA-derived BV equations (Wilson vs Smith-Ryan) using whole-body Hologic DXA tissue masses in collegiate rugby union athletes. METHODS: Twenty-one male rugby union athletes underwent whole-body DXA (Hologic Horizon W; APEX v5.6.1.3 Rev 007; Classic calibration [NHANES BCA disabled]; standard tissue analysis; daily QC within tolerance) during morning testing (06:00–09:00 h) while fasted and post-void; caffeine was avoided (≥12 h) and exercise was avoided (≥24 h). Hydration was assessed prior to scanning via urine specific gravity (Siemens CLINITEK Status+; Multistix 10 SG) and urine …

Agreement Of Seca 286 Scale Weight With Dxa Acquisition Weight, Apex Soft-Tissue Mass, And Dxa Sum-Of-Components Mass In Collegiate Rugby Athletes, Matthew Poole, Hayden Johnson, Christian Rivera, Stephanie Hansford, Regan Renfro, Dalton Prye, Saheed Jaiyeola, Sage A. Newman, Adesiji Adetona, Oscar Woodside, Jmya Hughes, Preston James, Kelly Hines, Jade Simon, Drew E. Gonzalez, Christopher D. Greenleaf, Micheil Spillane

International Journal of Exercise Science: Conference Proceedings

Accurate body mass is foundational for DXA-derived indices and longitudinal tracking. PURPOSE: Determine agreement between Seca 286 scale weight and DXA acquisition weight, quantify the difference between DXA acquisition weight and the APEX whole-body mass field (fat + lean), and evaluate a DXA sum-of-components mass (fat + lean + BMC) relative to scale weight as an internal QC check (Houtkooper et al., Am J Clin Nutr, 2000). METHODS: Twenty-one male rugby union athletes completed same-morning testing (06:00–09:00 h) while fasted and post-void; caffeine was restricted (≥12 h) and exercise abstained (≥24 h). Hydration was screened prior to DXA. Body mass …

Aerobic Capacity And Maximal Work Performance In Firefighters: The Role Of Age And Body Composition In Occupational Health Risk, Payton E. Miller, Michael Conner, Grant M. Tinsley, Drew E. Gonzalez, Christine M. Florez, Carina M. Velasquez, Kelly Hines, Jacob A. Mota

International Journal of Exercise Science: Conference Proceedings

Firefighting requires repeated bouts of high-intensity physical work performed under extreme environmental conditions, placing substantial strain on the cardiovascular and musculoskeletal systems. Cardiovascular disease (CVD) remains the leading cause of on-duty firefighter fatalities, with the majority of deaths occurring among firefighters aged 40 years and older. Physiological characteristics such as age and body composition influence aerobic capacity and maximal work performance, both of which are critical and essential while performing strenuous operations. PURPOSE: The purpose of this study was to examine how age, sex, and body composition affect aerobic capacity (VO_2peak) and maximal work capacity (W_{max …}

The Effect Of 8-Weeks Of Exercise Training On Metabolic Health And Continuous Glucose Monitoring Metrics Among Insulin Sensitive And Resistant Adults, Joshua Labadah, Adrian Ordaz, Seyram Azagloh, Richard Vazquez, Jehu N. Apaflo, Sudip Bajpeyi

International Journal of Exercise Science: Conference Proceedings

An elevated homeostatic model assessment of insulin resistance index (HOMA-IR) ≥ 2.5 is commonly used to classify insulin resistance (IR). IR is a well-established precursor to the development of diabetes and other metabolic diseases. Exercise is a well-established intervention for the improvement of metabolic health but the comparison of the effect of exercise among IR and insulin sensitive (IS) non-diabetic adults with the use continuous glucose monitoring has not been adequately studied.  PURPOSE: To determine if non-diabetic individuals with insulin resistance have attenuated improvement in exercise-induced improvement in metabolic health and CGM metrics of glycemic control in comparison to …

Neuromuscular And Body Composition Associations With Estradiol Throughout The Lifespan, Braden A. Wright, Tomas Chapman-Lopez, Micheal Luera, Jaci Kelly, Christine M. Florez, Lem Taylor, Darryn Willoughby, Mandy E. Parra

International Journal of Exercise Science: Conference Proceedings

Many studies have sought to understand estradiol withdrawal throughout the female lifecycle and its role in the brain and cognitive function, while little is known about its specific role at the neuromuscular junction and body composition. PURPOSE: The purpose of this study is to examine estradiol as a predictor of DXA- derived fat-free mass (FFM), lower body muscle quality (MQ), total fat mass (FM), and maximal muscle activation (EMG_RMS). METHODS: This is a secondary analysis from an existing data set using a cross-sectional design of eleven untrained women (pre-menopausal, n=6; age=23.3±4.3 years; height=160.6±8.3 cm; weight=60.5±11.6 kg; …

Delay In Increased Muscle Cross Sectional Area After Muscle Damage While Dehydrated, Sarah Walper, Casey Appell, Trinity Domonkos, Karina Olvera, Seth Bernardino, Jalyn Dunlap, Larry Munger, Hui-Ying Luk

International Journal of Exercise Science: Conference Proceedings

When muscles are damaged, the tears in the muscle fibers triggers an immune response and muscles experience inflammation. Inflammation increases WBC in the muscles to repair the micro tears. Muscle inflammation can be assessed by measuring the cross-sectional area (CSA) via ultrasound images. PURPOSE: To examine the effect of hydration status during recovery on muscle swelling after muscle damaging exercise. METHODS: Six recreationally active men (19 ± 1yr, 169.8 ± 8.3cm, 79.5 ± 11.7kg, Lean mass 58.6 ± 13.0kg, %body fat 28.3 ± 6.5%) completed two bouts of an identical muscle damaging exercise (DAM-EX) under a hydrated state and underwent …

Surviving The Cure: Modeling The Long-Term Consequences Of Chemotherapy, Rachel R. Chiella, Jaden Wells, Sajedeh B. Tabrizi, Savannah V. Rauschendorfer, Cory Dungan, Michael P. Wiggs

International Journal of Exercise Science: Conference Proceedings

Due to advances in treatment protocols, survival rates for childhood cancers have improved significantly over the past several decades, with five-year survival now reaching 85%. However, survivorship often comes at a cost, as exposure to intensive chemotherapy impairs skeletal muscle health, reducing quality of life and increasing the risk of early mortality. The CHOP regimen, comprising cyclophosphamide, doxorubicin, vincristine, and prednisone, is a backbone combination used in the treatment of childhood non-Hodgkin lymphoma. Previous data from our lab demonstrates that CHOP causes acute and reductions in growth and muscle size in juvenile mice, yet data on long-term outcomes remain limited. …

Effects Of Nasal Breathing Exercise On Systemic And Cellular Inflammatory Biomarkers, Tesleem Imran, Minh Quan Le, Brady Johnson, Jose M. Moris, Yunsuk Koh

International Journal of Exercise Science: Conference Proceedings

Effective inflammatory control is required to maintain proper immune function and health. While nasal breathing (NB) is recognized for its respiratory and cognitive benefits, its influence on immune regulation remains unclear. PURPOSE: The current study examined the effects of acute and chronic NB exercise on pro- and anti-inflammatory cytokines in serum and peripheral blood mononuclear cells (PBMCs). METHODS: Twenty-two sedentary men (age=21.55±2.58 years, height=180.98±7.89 cm, and weight=86.81±14.33 kg) were randomly assigned to either the NB (N=11) or combined breathing group (CB, N=11). Participants performed aerobic exercise on a recumbent cycle at a moderate intensity (70% VO₂max) for 4 …

The Metabolic Cost Of Three Different Modes Of Interval Exercise Versus Continuous Running, Kyle R. Brelsford, Enrrique Reyes, Austin Dunn, James Rowe

International Journal of Exercise Science: Conference Proceedings

Our lab has previously reported that Tabata performed with body calisthenics expends less energy when performed at the same intensity and duration as interval running and continuous running and that EPOC and energy expenditure (EE) during recovery were similar between these 3 exercises.  How EE and EPOC would respond to interval resistance exercise remains unclear.  PURPOSE: Compare the metabolic response to 4 exercise bouts when performed at a self-selected pace. METHODS: Active men (n=6) and women (n=4) performed 4 separate exercise bouts in a counterbalanced order: total body Tabata (TBT), treadmill running Tabata (TRT), continuous running (CONT) and interval resistance …

Caloric Misperception Of Unhealthy Foods As An Independent Determinant Of Visceral Adiposity, Grecia V. Morales, Cristina Grana Gedrange, Camila Guadiana, Marcela Guadiana, Samantha Martinez, Jose M. Moris

International Journal of Exercise Science: Conference Proceedings

Understanding the interplay between physiological markers and cognitive-behavioral traits is essential to identifying pathological contributors to adiposity. Poor health literacy, specifically the inability to gauge energy intake, is linked to maladaptive dietary behaviors, potentially exacerbating the accumulation of body fat percentage (BF%) and visceral adipose tissue (VAT). PURPOSE: To examine the extent to which body mass index (BMI), blood pressure (BP), and the perceived inaccuracy of food caloric content predict BF% and VAT in young women. METHODS: Nineteen young women (20.1 ± 0.9 years) participated in this cross-sectional study. Body composition (BF%, VAT) was assessed via Bioelectrical Impedance …

Sex Differences In Carbohydrate Quality: Assessing The Carbohydrate-To-Fiber Ratio In Middle-Aged Hispanic Adults, Cristina Graña Gedrange, Mia I. Perez, Marcela Guadiana, Nicole Cantu, Jose M. Moris

International Journal of Exercise Science: Conference Proceedings

Hispanic adults in the United States face disproportionate rates of cardiometabolic disease, yet sex-specific disparities in diet quality remain understudied. PURPOSE: To determine diet quality among middle-aged Hispanic adults, assessing carbohydrate quality based on the carbohydrate-to-fiber ratio (CFR) and protein density as indicators of metabolic risk. METHODS: A total of 30 males and 49 females between 40 to 70 years old participated in a cross-sectional analysis of body composition and dietary behavior. Participants underwent girth measurements, a dual-energy X-ray absorptiometry scan, and completed a paper-based 3-day dietary recall log. Dietary data were manually entered by researchers using an …

Accelerated Skeletal And Cardiometabolic Decline In Hispanic Women Versus Stability In Men During Mid-Life, Camila Guadiana, Grecia V. Morales, Marianna Gamboa, Jose M. Moris

International Journal of Exercise Science: Conference Proceedings

Mid-life represents a critical physiological juncture where skeletal and metabolic health often diverge. While Hispanic adults are known to face elevated risks for both osteoporosis and cardiometabolic disease, the specific temporal synchronization of these declines, particularly the concurrent acceleration of bone loss and visceral adiposity, remains understudied in this population. PURPOSE: To examine sex-specific differences in body composition, bone mineral density (BMD, g/cm²), and blood pressure across three mid-life decades (40s, 50s, 60s) in Hispanic adults. METHODS: This cross-sectional study included 100 Hispanic adults (36 men and 64 women) from Laredo, TX, stratified into age groups 40-49, 50-59, …

Beyond The Scale: Exercise Frequency Reflects Metabolic Health Independent Of Adiposity, Macilynn E. Coles, Nicole Cipriano, Diana Kolb, Ross Moody, Martin R. Lindley, Sarah Deemer

International Journal of Exercise Science: Conference Proceedings

Physical activity (PA) is an important determinant of metabolic health, yet individuals with similar body mass can differ in metabolic function. Frequency of aerobic (AT) and/or strength training (ST) may differentiate metabolically healthy from unhealthy individuals, independent of body composition. PURPOSE: To compare AT and ST frequency among metabolically healthy lean (MHL), and metabolically healthy (MHO) and metabolically unhealthy (MUO) adults with obesity. METHODS: 59 men and women arrived at the Applied Physiology Lab following an overnight fast (0700h-0900h). Metabolic health (MH) status was assessed by cardiometabolic disease (CMD) history, resting blood pressure (BP), lipid profile, and fasting and 2h …

Fatigue-Matched Three Different Squats Elicit Blood Lactate Responses In Young Adults, Jiwon Song, Kase Pennartz, Wonjae Lee, Sarah Deemer, Jakob Vingren, David Church, Joshua L. Keller

International Journal of Exercise Science: Conference Proceedings

Resistance exercise (RE) with blood flow restriction (BFR) promotes muscle hypertrophy, using low external loads and may also improve cognitive function and neuroplasticity, possibly by increasing brain-derived neurotrophic factor (BDNF). Lactate accumulation during exercise has been proposed as a potential mediator of exercise-induced increases in BDNF. However, it is unclear whether different RE loading strategies or BFR under fatigue-matched conditions produce distinct lactate responses that could differentially influence downstream neurotrophic mechanisms. PURPOSE: This study examined blood lactate responses for high-load (HL), low-load (LL), and LL-BFR RE in recreationally active young adults. METHODS: Sixteen healthy, recreationally active young adults …

Do Body Composition And Cardiovascular Fitness Differ By Gender In Firefighters?, Giuliet L. Kibler, Kelly Hines, Michael J. Conner, Lisa C. Colvin, Steven E. Martin, Drew E. Gonzalez

International Journal of Exercise Science: Conference Proceedings

Firefighters (FF) endure substantial cardiovascular stress during their occupational tasks; yet, males and females differ in cardiovascular fitness (CRF) due to biological factors. The differences in body composition (BC) and CRF among FFs remain unclear. PURPOSE: To compare gender-specific outcomes in body BC and cardiopulmonary exercise test (CPET) of FF. METHODS: BC assessments via BIA and CPET on a cycle ergometer for 509 FF were analyzed from annual clinical testing. Gender was self-reported as follows: female (n = 29), male (n = 476), or other (n = 4). BC metrics, including body fat, lean body mass, skeletal muscle …

How Do Firefighters Differ Between Years Of Fire Service Experience: Part 1 - Physical Fitness Profiles, Ian Bivins, Michael J. Conner, Jacob A. Mota, Payton Miller, Steven E. Martin, Lisa C. Colvin, Drew Gonzalez

International Journal of Exercise Science: Conference Proceedings

Firefighters (FF) face a higher risk of cardiovascular disease (CVD) due to aging, job-related stress, and irregular physical activity. Years of experience (YXP) in the fire service have been shown to have a unique impact on FF health and performance; however, profiling the differences between those with less or more YXP has not yet been assessed. PURPOSE: To examine years of experience-related differences in conventional physical fitness parameters among FFs. METHODS: Archival data from annual clinical testing of 142 FFs were analyzed. Groups were defined as those with 5 YXP. General linear models (GLM) were used for multivariate …

Evaluating Self-Reported Dietary Habits And Barriers Among Rotc Cadets Across Body Mass Index Classifications, Sarah E. Johnson, Sheyla Leon, Michael Conner, Lisa Colvin, Steven Martin, Stella Volpe, Drew Gonzalez

International Journal of Exercise Science: Conference Proceedings

Limited data exist on the overall and sports nutrition knowledge among Reserve Officer Training Corps (ROTC) cadets across different body mass index (BMI) categories. PURPOSE: We aimed to study ROTC cadets' dietary habits and barriers across BMI groups. METHODS: Cross-sectional data were obtained from 184 ROTC cadets regarding validated questionnaires, such as the Perceived Barriers to Healthy Eating (PBHE), Food Choice Questionnaire (FCQ), and Rapid Eating Assessment for Participants-Short Version (REAPS). The cadets were stratified into body mass index (BMI) groups: underweight (RESULTS: Chi-square analyses showed BMI-related differences in responses to REAPS' breakfast skipping question (χ²=14.289, p=0.027, V=0.199), …

Evaluation Of Bone Turnover Markers And Biochemical Analysis In Developmental Metabolic Bone Diseases In Pediatric Aksaray Malakli Breed Dogs, Nihan Avci, Fehmiye Gumus Ozdil, Basak Boztok Ozgermen

The Thai Journal of Veterinary Medicine

Pediatric dogs are predisposed to skeletal disorders during growth, with rickets, hypertrophic osteopathy, and nutritional secondary hyperparathyroidism being the most common. Rickets, usually caused by vitamin D deficiency, leads to bone softening and deformities, whereas hypertrophic osteopathy involves abnormal calcium salt deposition that impairs mobility. This study investigated developmental orthopedic diseases in Aksaray Malakli dogs, focusing on nutritional factors and biochemical markers. Twenty-two pediatric dogs were examined and divided into two groups. Group I (n=11) showed gait abnormalities and postural deformities, whereas Group II (n=11) included clinically healthy dogs. Clinical, radiographic, and biochemical assessments were performed, including cortical index, parathormone, …

Gender Differences In College Students’ Physical Activity Self-Efficacy, Social Comparison Beliefs, And External Frames Of Reference, Ken Murfay, Sarah Pyszczynski, Sarah Collins

International Journal of Physical Activity and Health

This study examined whom college-aged individuals believe observing would more likely increase their physical activity self-efficacy (PASE) for a physical skill, whom they are more likely to compare their abilities to within a physical education (PE) class, how often they compare themselves to others in PE, and what students’ PASE scores were. Based on the mean scores for each question, students were more likely to compare themselves to a student than a teacher, friend than a non-friend, and similar or higher skilled peer than a lower skilled peer. To increase students’ confidence for a physical skill, students had higher levels …

Association Between Children’S Secondhand Co-Exposure To Tobacco And Cannabis Smoke And Elevated Urinary Cotinine Levels: A Cross-Sectional Analysis, Bradley N. Collins, Stephen J. Lepore, Vincent Berardi, Renee D. Goodwin, Karen Wilson, Mona Baishya

Psychology Faculty Articles and Research

Background Cannabis use is far more common among adults who smoke tobacco than adults who do not, and its use is increasing among people who smoke tobacco with children living in the home. Given the well-established evidence that caregiver smoking is the primary source of children’s secondhand exposures to these products, the increasing trend in caregiver co-use is raising public health concerns about children’s co-exposure. Emerging data indicates that adult co-use is linked to additive health consequences, such as elevated nicotine and other tobacco-related toxicant blood levels, relative to use of only tobacco. It is unknown whether children’s co-exposure leads …

Steroid Receptor Coactivators - From Basic Research To Translational Opportunities, Yosef Gilad, Sang Jun Han, David M Lonard

Faculty, Staff and Students Publications

The concept of nuclear receptor (NR) coregulation was proposed nearly two decades before it was experimentally validated. According to this model, NRs - executors of a vast array of transcriptional programs - do not act independently but are governed by a network of regulatory proteins that either activate or repress their biological function. NRs identify the genes to be regulated. However, coregulators ultimately serve as the true controllers of transcriptional outcomes. They recruit cofactors and coordinate the activity of transcriptional complexes, thereby shaping NR-mediated gene expression beyond NRs' intrinsic functionality. The Steroid Receptor Coactivator (SRC) family is the most extensively …

Renin-Angiotensin-Aldosterone System In Preeclampsia: Pathophysiological Insights And Links To Vascular Dementia, Robin C. Finch, Jenny Lutshumba, Elizabeth Mirsky, Esther Ndashaala, Kelsey Bullens, Emma Smith

Pediatrics Faculty Publications

Pre-eclampsia, a condition characterized by new-onset hypertension during pregnancy and one or more indices of organ damage, is a major driver of both short and long-term maternal health outcomes. Individuals with a history of pre-eclampsia are at increased risk for cardiovascular, renal, and other chronic diseases. Recent studies have linked pre-eclampsia history with increased risk of dementia later in life, underscoring the importance of new guidelines emphasizing blood pressure control to reduce the risk of cognitive decline. Unfortunately, neither mechanisms underlying causes of pre-eclampsia nor their links with cognitive function are well understood. Vascular contributions to cognitive impairment and dementia …

The Neuroprotective Effects Of Alpha-Tocopherol As An Anti-Inflammatory Agent: Mechanistic Insights And Therapeutic Challenges, Megumi H Seese, Yuanzhong Xu

The Brown Foundation: Institute of Molecular Medicine

Vitamin E (alpha-tocopherol, αToc), an antioxidant fat-soluble vitamin that prevents lipid peroxidation and modulates pro-inflammatory cytokine production, is well-known to be critical for neuroprotection. However, the underlying mechanism remains poorly understood. Accumulating evidence demonstrates that αToc influences neuroinflammatory processes. Here, we review recent research progress on the effects of αToc on neuroinflammation. Preclinical studies included in this narrative review were identified through PubMed searches using the keywords "alpha-tocopherol AND neuroinflammation or alpha-tocopherol AND brain AND inflammation". While many studies support a neuroprotective role of αToc, the magnitude and direction of its effects vary substantially depending on dosage, route of administration, …

The Cost Of A Healthy Diet And Its Association With Bmi In Crisis-Stricken Lebanon, Maha Hoteit, Myriam Abboud, Maroun Khattar, Rana Rizk

All Works

Objectives: This study aimed to determine the prevalence of Lebanese adults living with underweight, overweight or obesity, assess and compare the cost of the Mediterranean Diet (MD) with that of the current dietary consumption pattern and explore diet cost as a determinant of living with underweight, overweight or obesity. Design: Data for this nationally representative cross-sectional study were collected through sociodemographic questionnaires, anthropometric measurements, the Arab Family Food Security Scale and dietary assessments using a validated FFQ and 24-h recalls. Diet costs were calculated based on 2023 market prices using purchasing power parity. Logistic regression was used to assess associations …

Survival On Image Regression With Application To Partially Functional Distributional Representation Of Physical Activity, Rahul Ghosal, Sunwoo Emma Cho, Marcos Matabuena

Faculty Publications

Technological advancements in wearable devices and medical imaging often lead to high-dimensional physiological signals in the form of images or surfaces. To address these data structures, we develop a novel survival on image regression model with a specific focus on partially functional distributional representation of wearable data. The existing approaches for functional data and survival outcomes have been primarily developed for uni-dimensional functional predictors. Drawing on recent developments in distributional data analysis, we model temporally varying distributional patterns of physical activity (PA) as a partially functional distributional predictor within a semiparametric Cox model framework. We use tensor product splines to …

Sex-Specific Differences In Mediobasal Hypothalamus In Response To Nutritional States, Jonathan C Bean, Jinjing Jian, Tzu-Chiao Lu, Hailan Liu, Kristine Conde, Darah A Threat, Sanika V Jossy, Megan E Burt, Jingjing Cheng, Yue Deng, Xing Fang, Xiaoyu Geng, Junying Han, Yongxiang Li, Hesong Liu, Qingzhuo Liu, Yutian Liu, Yuhan Shi, Longlong Tu, Mengjie Wang, Xu Xu, Yuxue Yang, Meng Yu, Xinming Liu, Meixin Sun, Fuhui Wang, Olivia Z Ginnard, Yongjie Yang, Yang He, Chunmei Wang, Yanyan Qi, Hongjie Li, Yong Xu

Children’s Nutrition Research Center Staff Publications

The arcuate nucleus of the hypothalamus plays a central role in sensing and integrating nutritional, hormonal, and neural signals that regulate feeding, energy homeostasis, growth, and reproduction, all of which show pronounced sex differences. However, the cellular mechanisms underlying these responses remain poorly understood. We performed snRNA-seq of the mediobasal hypothalamus, focusing on the arcuate nucleus, in female and male mice under different nutritional states. Analysis of 42 cell types revealed that Agrp neurons were most sensitive to nutritional changes, dopaminergic neurons showed strong sex-specific differences, and KNDy neurons were highly responsive to both sex and nutrition. Pomc neurons displayed …

Propofol In Chronic Cannabis Users: A Mechanistic Link To Cannabinoid Hyperemesis?, Jonmark I. Dolendo, Sonia Frick, Jia Q. Yang, Brad A. Haubrich

Annual Research Symposium

Purpose: Cannabinoid hyperemesis syndrome (CHS) is characterized by cyclic nausea, vomiting, and abdominal pain in chronic cannabis users, often relieved by exposure to hot water. Propofol, a widely used GABAergic anesthetic with antiemetic properties, has paradoxically been implicated in exacerbating hyperemetic episodes in some cannabis users. With the growing legalization of marijuana and social acceptance to its recreational use it is believed that this phenomenon will be more ubiquitous to clinicians. This review aims to investigate the mechanistic and clinical evidence linking propofol administration to CHS and to summarize strategies for prevention, diagnosis, and management.

Methods: PubMed and EBSCO were …

Staff Education To Improve Provider Knowledge In Addressing Sdoh-Related Barriers Affecting Medication Adherence, Andrea Latimore

Walden Dissertations and Doctoral Studies

This Doctoral of Nursing Practice (DNP) project focused on improving provider knowledge in addressing social determinants of health (SDOH) that contribute to medication nonadherence. There is a gap in provider knowledge in addressing SDOH-related barriers that contributes to poor health outcomes. Increasing provider awareness of SDOH improves patient outcomes. The practice-focused question guiding this doctoral project asked whether an educational module on SDOH improved provider knowledge in addressing SDOH-related barriers to medication adherence among adult patients with chronic illnesses. The program consisted of a pretest, an educational module delivered via a PowerPoint presentation, and a posttest. A total of 20 …