Digital Commons Network^™

Early Life Exposure To Antibiotics Increases The Risk Of Myopia: A Retrospective Cohort Study, Peng-Tai Tien, Chang-Ching Wei, Sheng-Chun Lin, Ping Ping Meng, Yu-Te Huang, Jamie Jiin-Yi Chen, Ming-Yen Wu, Ying-Hsiu Shih, Tzu-Ju Hsu, Fuu-Jen Tsai, Yao-Chien Wang, Hui-Ju Lin, Lei Wan

BioMedicine

Background

Myopia is a growing health issue, expected to affect nearly half of the global population by 2050. Genetic predisposition and early environmental influences both play crucial roles in the development of myopia. Identifying modifiable risks and early interventions is critical. Antibiotics, commonly given to young children, may disrupt gut microbiota, which has been linked to ocular diseases in humans and animals.

Aim We aimed to investigate the association between antibiotic use in early life and the risk of developing myopia.

Methods Retrospective cohort study using data from a national health insurance database examined children aged three years or younger, …

Traditional Chinese Herbal Medicines Suppress Endometriosis Development Through Modulating Macrophage-Mediated Immune Responses In The Peritoneal Cavity, Cherry Yin-Yi Chang, Kung-Pin Chang, Pei-Fen Lee, Hsiang-Hao Chuang, Yun-Yi Su, Yu-Chi Chang, Man-Ju Yan, Chih-Mei Chen, Tritium Hwang, Huan-Yuan Chen, Chia-Jung Lig, Zhi-Hong Wen, Kuan-Hao Tsuig, Lun-Chien Lo, Jim Jinn-Chyuan Sheu

BioMedicine

Background: Due to unique dietary culture, Asian patients with endometriosis usually seek assistance through traditional Chinese herbal medicine (TCHM), making combined treatments of Western and Chinese medicine quite common in Asia. However, limited molecular evidence has been provided to demonstrate the therapeutic benefits of TCHM in treating endometriosis.

Aims: To investigate the functional impacts of TCHM treatment in their traditional formulae on peritoneal immunity, lesion growth, and adhesion formation, we performed studies by using a disease mouse model that exhibits the features of blood stasis and stagnation.

Methods: Four well-known TCHM formulae, frequently used for treating symptoms similar …

Evaluation Of Bai-Zhu (Atractylodes Macrocephala)-Based Herbal Formulae In Breast Cancer: Implications For Metastasis Via Zeb1 And Slug Modulation, Yen Shen Lu, Pei Yen Yeh, Ling-Chun Yeh, Chia-Lin Lee, Ying-Chyi Song

BioMedicine

Background: Bai-Zhu (Atractylodes macrocephala Koidz. [Asteraceae]) is classified in traditional Chinese medicine (TCM) as an herb that targets the gastric and pancreatic meridians to support normal nutrient uptake. As such, Bai-Zhu is commonly included in herbal formulations for treating gastrointestinal dysfunction and alleviating pain and swelling. Formulae containing Bai-Zhu are also frequently used as complementary or alternative therapies to mitigate the side effects of tumor treatments. However, their direct effects on cancer cells remain inadequately understood in modern biomedical science. This study aims to characterize the impact of Bai-Zhu-containing formulae on breast cancer cells using contemporary molecular and cellular …

Extending Sbar To Sbar-A: A Practice-Based Framework For Dnp Clinical Scholarship, Cynthia Plonien

Nursing Faculty Publications & Presentations

The SBAR (Situation, Background, Assessment, Recommendation) framework is widely used to structure communication in healthcare settings. However, its traditional use emphasizes information exchange rather than practice change. Doctor of Nursing Practice (DNP) education requires translation of evidence into action through measurable practice change and leadership engagement. This manuscript introduces SBAR-A, an adaptation of the SBAR framework that adds an “Action” component requiring application of evidence-based interventions. SBAR-A integrates planning, leadership, and the application of knowledge to practice. This framework provides a structured approach for bridging communication and practice change within DNP clinical scholarship.

Expert Recommendations To Strengthen Chikungunya Outbreak Surveillance And Reporting For Traveler Health Protection, Daniel C. Payne, Karoun H. Bagamian, Jeffery Goad, Nathan D. Grubaugh, Michael A. Johansson, Moritz U. G. Kraemer, Eyal Leshem, Francesca F. Norman, Alfonso J. Rodríguez-Morales, Henrik Salje, Stephen Thomas, Scott C. Weaver, Lindsey A. Laytner, Rebecca Sturgis, Suzanne K. Scheele, Davidson H. Hamer

Pharmacy Faculty Articles and Research

Chikungunya, a debilitating mosquito-borne disease caused by chikungunya virus, has surged dramatically in the past two decades. Chikungunya outbreaks can intensify rapidly, with infections posing a significant endemic health burden in tropical/subtropical areas and for travelers. Health professionals require timely and accurate outbreak information to adequately protect travelers and assess chikungunya risk. However, detection is often insufficient in the areas most susceptible to outbreaks, leading to diagnostic and reporting delays. Consequently, travelers are often unaware of increased chikungunya infection risk at their destination. We assessed chikungunya surveillance and reporting resources, and we developed expert recommendations for traveler health protection. Because …

Food Insecurity And Mental Health Among High School Students: Evidence From National And Virginia Youth Risk Behavior Surveillance Data, Nigel C. James, Asef Raiyan Hoque, Jada Pedersen, Huong Doan, Liam Hayes, Leah Suggs

Health Studies Faculty Publications

Background

Youth mental health problems are rising nationally. Virginia ranks among the lowest states in youth mental health access and has concentrated pockets of food insecurity (FI), underscoring the urgency of policy responses. FI is a known risk factor, yet surveillance often relies on single-item measures. We introduce a multidimensional Food Insecurity Index (FII) to examine associations with adolescent mental health.

Methods

We analyzed 2023 Youth Risk Behavior Surveillance System data from Virginia (n = 1866) and the United States (n = 10,724). The FII combined five indicators capturing acute scarcity and chronic dietary compromise. Survey-weighted logistic regression …

Editor’S Note: Responsive Health Sciences: Integrating Education, Equity, And Community Care, Rolando Lazaro

Philippine Journal of Physical Therapy

No abstract provided.

Modulate Obesity And Related Metabolic Complications For Yielding Improvements In Ibd Outcomes (Modify-Ibd): Consensus On Obesity And Cardiometabolic Comorbidities In Inflammatory Bowel Disease Using Systematic Reviews And The Rand/Ucla Appropriateness Method, Jalpa Devi, Sami Samaan, Priya Sehgal, Mouhand Mohamed, Matthew Vincent, Shannon Coombs, Michelle Doering, Edward L. Barnes, Amanda M. Johnson, Andres J. Yarur, Parakkal Deepak

Division of Gastroenterology and Hepatology Faculty Papers

INTRODUCTION: Obesity and related cardiometabolic comorbidities, including hypertension, dyslipidaemia, diabetes, metabolic dysfunction-associated steatotic liver disease and atherosclerotic cardiovascular disease, are increasingly prevalent among individuals with inflammatory bowel disease (IBD). These conditions influence disease activity, therapeutic response, surgical outcomes and overall quality of life, yet evidence remains fragmented. The Modulate Obesity and relateD metabolic complIcations For Yielding improvements in IBD outcomes (MODIFY-IBD) initiative aims to synthesise evidence and generate consensus recommendations to guide practice and future research in this area. This study describes a protocol for a structured evidence synthesis and Research And Development/University of California, Los …

Internalized Homophobia As An Influence On Participation In Hiv Prevention Among Young Men Who Have Sex With Men (Ymsm), Kasey I. Brazee

Honors Scholar Theses

Stigma is a known barrier to accessing preventative services for human immunodeficiency virus (HIV), however, the types of stigmas involved in this relationship remain not well defined. Homophobia, or negative attitudes directed towards homosexuality, is a particularly important type of stigma considering the disproportionate effect of HIV on men who have sex with men (MSM). Young MSM (YMSM) are especially impacted, making them a key population in the context of HIV prevention research.  Internalized homophobia, which refers to homophobia that one directs towards themselves, is under researched regarding its role in participating in HIV prevention. In this study, we aimed …

Experiences Of First-Generation Immigrant Parents In Caring For Children With Type 1 Diabetes, Nahel Kibreab

Walden Dissertations and Doctoral Studies

No abstract provided.

Examining The Ligands, Location, And Function Of Toll-Like Receptor 10, Kiefer Keanu Tam

Master's Theses

Toll-like receptors are a class of innate immune pattern recognition receptors that detect pathogen-associated molecular patterns and regulate downstream inflammatory responses. Toll-like receptor 10 remains the only human TLR whose ligand specificity, cellular localization, and immunological function are not fully defined. Emerging evidence suggests that TLR10 may play an anti-inflammatory role and can heterodimerize with TLR2 to modulate immune signaling. Previous studies from our laboratory demonstrated that stimulation with heat-killed Mycobacterium tuberculosis promotes TLR2-TLR10 heterodimerization and trafficking to the cell surface. In this study, we expanded our ligand panel to include additional gram-positive bacteria, particularly anti-inflammatory probiotic species, to further …

Psychological Strain And Infrastructure Deficit And The Decision To Migrate Among Healthcare Workers From Lagos, Nigeria, Fatima Adeboye

Walden Dissertations and Doctoral Studies

No abstract provided.

The Parent Phone Use Regulation Efficacy Scale (P-Pure): Initial Validation And Associations With Problematic Smartphone Use, Self-Regulation, Impulsivity, Mindfulness, And Self-Efficacy, Brandon T. Mcdaniel, Sabrina Uva, Adam M. Galovan

Health Services and Informatics Research

Parents often rely on smartphones in daily life. While smartphones offer benefits, they also present challenges, such as potential distraction and delayed responsiveness. It is also possible that problematic smartphone habits may develop, such as repeated checking or difficulty controlling use. Furthermore, self-efficacy around regulating one’s phone use is tied to the ability to change, meaning self-efficacy could be a key mechanism impacting the effectiveness of interventions regarding problematic phone use. Thus, we developed and explored the validity of the Parent Phone Use Regulation Efficacy Scale (P-PURE) to assess parents’ self-efficacy in managing phone use around their children. We developed …

Advancing School-Based Sexual Reproductive Health Education Through A Fifth-Grade Educator Toolkit, Emira Romero

Doctor of Nursing Practice (DNP) Projects

Background: Although sexual and reproductive health (SRH) education is a critical component of early health literacy and health promotion, educators remain underprepared to deliver this education. Local Problem: A gap analysis conducted at School A, a public elementary school in the San Francisco Bay Area, revealed the absence of a SRH curriculum for their fifth graders. Methods: A Doctor of Nursing Practice (DNP) student-led quality improvement project to introduce a SRH educator toolkit to increase educator confidence and self-efficacy was conducted at School A among fifth grade teachers. Pre- and post-intervention data were collected on implementation day to evaluate the …

Soft Power, Arab Media And Sports Mega Events: Coverage Of Fifa 2022 And Lessons For Future Arab Hosting, Lynne Kennedy, Maaira Shahbaz, Ala Al Rajabi

All Works

Sport mega-events (SMEs) increasingly transcend athletic competition, functioning as strategic instruments for national identity formation, statecraft, and soft power projection. This dynamic is particularly pronounced in the Gulf, where Qatar’s successful hosting reignited regional rivalries and attracted unprecedented global scrutiny. While existing scholars have extensively examined Western media portrayals of SMEs, a notable gap remains for academic engagement with Gulf media. Dismissed as state-controlled and analytically lacking, we contend that such media offer a rich site for exploring how small states use media as soft power, to construct and contest legitimacy, identity, and global influence. This analysis suggests how state-aligned …

Deep Cuts: Bearing Witness To The Erosion Of Evidence, Maya Lakshmi Srinivasan Md

Masters Theses

In my Master of Fine Arts thesis in Printmaking at the Rhode Island School of Design, I examine the intersection of my dual practices as a general surgery resident and artist. Both disciplines require precision, incision, and tactility to navigate the human condition. My art practice is a method of processing the emotional toll of surgical training and the simultaneous societal erosion of scientific authority. My thesis work focuses on challenging the rise of medical pseudoscience and anti-intellectualism. The focal piece in this installation, In Tallow We Trust, consists of three woodblock relief prints at the scale of an …

Cd11c+ Cd8 T Cells Cause Ifn-Γ-Dependent Autoimmune Neuroinflammation That Is Restrained By Pd-1 Signaling, Daniel Hwang, Gholamreza Azizi, Larissa Lumi Watanabe Ishikawa, Maryam S. Seyedsadr, Arin Cox, Soohwa Jang, Ezgi Kasimoglu, Abdolmohamad Rostami, Guang-Xian Zhang, Bogoljub Ciric

Department of Neurology Faculty Papers

In multiple sclerosis (MS) lesions, CD8 T cells outnumber CD4 T cells, suggesting that they contribute to MS pathology. However, little is known about the role of CD8 T cells in MS, partly due to the prevalent use of experimental autoimmune encephalomyelitis (EAE) models mediated by CD4 T cells, which have limited involvement of CD8 T cells. Importantly, MS and EAE differ in both their distribution of CNS lesions and neurologic deficits, indicating differences in CNS inflammation. MS lesions are more commonly found in the brain, whereas EAE lesions are more frequent in the spinal cord. Additionally, neurologic deficits in …

Why Theory Matters In Infant And Toddler Practice: Unpacking Pikler, Gerber, Gesell, Piaget, & Vygotsky, Derrick Toups

Spark! Innovations in Early Childhood Education: A Research-to-Practice Journal for Educators

This article is intended to help infant and toddler educators deepen the why behind the what and how of their daily interactions by unpacking and connecting the seminal early childhood theories of Pikler, Gerber, Gesell, Piaget, and Vygotsky, what they look like in the classroom, and why they benefit children.

Exploring The Impact Of Mental Health On Childhood Obesity In Southern African American Youth Ages 12-18, Shari Scott Robinson

Walden Dissertations and Doctoral Studies

No abstract provided.

Using The Socio-Ecological Model To Explore Parents' Resilience And Perceptions Of Adverse Childhood Experiences: A Qualitative Study In The Southeastern United States, Maribel G Dominguez, Christine Markham, Andrew E Springer, Louis D Brown

Faculty, Staff and Student Publications

Background: The negative impact of adverse childhood experiences (ACEs) on child development is documented. The parent-child relationship protects against ACEs and improves healthy child development, playing a crucial role in preventing and mitigating ACEs by strengthening parental resilience. However, there is a gap in the literature on our understanding of parental resilience's impact on the parent-child relationship within the social-ecological model (SEM) (i.e., intra- and interpersonal, community, and societal levels). Objective: This study explores parents' perspectives on parental resilience as a protective factor for preventing and mitigating ACEs at every level of the SEM. Method: This study uses a thematic …

Hiv/Aids-Related Awareness And Misconceptions Among Grade 10 Students In Muttrah Wilayat, Muscat, Oman: A Descriptive, Cross-Sectional Study, Rahma Abdullah Al Riyami, Balqees Ahmed Al -Maawali, Nabila Hamood Al Wahaibi, Mariam Rashid Al Rashdi, Fatma Ahmed Al Hinai

Sultan Qaboos University Medical Journal

Objectives: Despite Oman having a low HIV prevalence, stigma and lack of knowledge among young people may hinder prevention efforts. This study aimed to assess HIV/AIDS-related knowledge and misconceptions among Grade 10 students in Muttrah wilayat in Oman. Methods: This cross-sectional study was conducted in February 2025 and included Grade 10 students from 4 governmental schools in Muttrah selected via proportional stratified sampling. The sample size was calculated depending on the number of students in Grade 10. Data collection was performed during face-to-face interviews using a validated Arabic-language questionnaire. Results: A total of 271 Grade 10 students were included in …

Vol 6. May '26 Full Issue, Donna L. Williams

Journal of the Louisiana Public Health Association

No abstract provided.

Identifying Barriers To Pursuing Allied Health Careers- Findings From The Lsuhs Ahead Program, Adrienne Brecheen Davis, Laura E. Gray, Madeline F. Barclay, Hilary K. Bates

Journal of the Louisiana Public Health Association

Background: In Louisiana, underrepresented minorities (URMs) compared to the general population face significant disparities in representation within allied health professions.¹ Although Blacks/African Americans represent 31.4% of the state’s population, they comprise only 1.5% of physical therapists, 4.5% of occupational therapists, 2.7% of physician assistants, and 12.7% of speech-language pathologists. Similarly, while the Latinx population makes up 4.8% of Louisiana’s population, they represent only 0.5% of physical therapists and 2.7% of physician assistants. These persistent disparities point to systemic educational barriers and structural inequities that limit access to health profession programs. This study investigated the perceived barriers underrepresented students face when …

Mapping Youth Sexual And Reproductive Health Services In Orleans Parish, Louisiana: A Field-Tested Survey Methodology, Isabelle Jouve, Ryann Martinek, Zoey Ponder, Isabel Arce, Ryley White

Journal of the Louisiana Public Health Association

Background: Fragmented access to sexual and reproductive health (SRH) services is driving a sexual health crisis among the youth population in Orleans Parish, Louisiana. Rates of sexually transmitted infections, HIV, and teen pregnancy continue to rise while SRH education offerings decline. In response to these outcomes, a Sexual Health, Education, and Rights (SHER) Lab team presents a field-tested survey methodology to characterize the landscape of youth-accessible SRH service providers. Methods: In May 2025, the SHER Lab launched an SRH landscape assessment project to survey youth-serving organizations in Orleans Parish, Louisiana. The project team collected comprehensive feedback from community stakeholders to …

Early Chemical Markers Of Spoilage In Thermally Processed Tomato Paste: A Rapid Approach For Shelf-Stable Foods, Hussein Ali Shaghati, Rawia Mahmood Yousif

Al-Nisour Journal for Medical Sciences

This study aims to reduce the incubation period (commercial sterility test) of tomato paste cans before the bacteriological inspection in quality control laboratories. 62 cans of tomato paste were incubated under temperatures (mesophilic 25,37°C and thermophilic 55°C) to accelerate potential spoilage. Chemical indicators(pH, titratable acidity, and lactic acid) and microbial indicators (Total plate count and yeast/molds) were monitored daily to identify the earliest reliable spoilage signals. Incubation at elevated temperatures accelerated acid buildup. D+L lactic acid levels measured using a rapid enzyme assay increased with titratable acidity, while pH decreased. Meanwhile, total platelet counts remained at very low levels, while …

Mitochondrial Ca2+ Uniporter (Mcu) Variants Form Plasma-Membrane Channels, Iuliia Polina, Jyotsna Mishra, Michael Cypress, Maria Landherr, Nedyalka Valkov, Isabel Chaput, Bridget Nieto, Brian Rhee, Ameneh Ahrari, Nathan Demichaelis, Kye-Im Jeon, Ulrike Mende, Peng Zhang, Bong Sook Jhun, Jin O-Uchi

Center for Translational Medicine Faculty Papers

MCU, originally known as CCDC109A, is widely recognized as the gene responsible for encoding a pore-forming subunit of a Ca2+-selective channel, mitochondrial Ca2+ uniporter complex (mtCUC). While MCU expression is typically highly mitochondrial-specific, we report here a protein variant derived from the MCU gene, termed MCU-S, which lacks the mitochondria-targeting sequence (MTS) and forms a Ca2+-permeable channel outside of mitochondria. The mRNA of MCU-S was ubiquitously expressed in all cell types/tissues tested, with particularly high expression in human platelets. MCU-S protein formed Ca2+ channels at the plasma membrane, which exhibited similar channel properties to those observed in mtCUC. MCU-S channels …

Improving Hyaluronic Acid Filler Safety Through A Structured, Evidence-Based Training Program: A Dnp Educational Initiative, Carlos Sandoval Madrigal

Doctoral Projects

The rapid growth of aesthetic medicine, particularly the use of hyaluronic acid (HA) dermal fillers, has outpaced the development of standardized educational pathways for Health Care Providers (HCPs), contributing to a wide variability in clinical practice and increased risk of adverse events. This Doctor of Nursing Practice (DNP) project aimed to evaluate the effectiveness of a structured, evidence-based educational intervention designed to improve provider knowledge and confidence in the prevention and management of HA filler complications. The intervention was developed using the 10-Point Plan framework and evaluated using the Kirkpatrick Model Levels 1 (Reaction) and 2 (Learning). A quasi-experimental, one-group …

Improving Staff Competence In Phq-9 Administration, Obinna C. Okonkwo

Walden Dissertations and Doctoral Studies

No abstract provided.

Factors Associated With Vaping Frequency Among University Students, Oluwatosin Marylyn Oduneye

Masters Theses

Electronic cigarette use among university students is a growing public health concern, with approximately 20-25% reporting current use. Despite extensive research on vaping initiation, factors associated with vaping frequency among established users remain understudied. This study examined stress-coping mechanisms, peer influence, and health risk perceptions as predictors of vaping frequency, guided by Bandura's Social Cognitive Theory (SCT). A quantitative cross-sectional survey was administered via Microsoft Forms to 399 university students aged 21-25 with recent vaping experience, recruited nationally through campus flyers and online platforms. Multiple linear regression was conducted in SAS OnDemand for Academics, with stress-coping, peer influence, and health …

The Association Between Diet Quality, Nutritional Knowledge, Low Energy Availability, And Eating Disorder Risk In Collegiate Student-Athletes, Laurel Koontz Awald

Doctoral Dissertations and Projects

This study aimed to investigate the association between diet quality, nutritional knowledge, low energy availability, and eating disorder risk in a sample of collegiate student-athletes across several sporting disciplines. The quantitative cross-sectional survey was developed using validated questionnaires to investigate diet quality (The Athlete Diet Index), nutritional knowledge (The Platform for Evaluating Athlete Knowledge in Sports – Nutrition Questionnaire), low energy availability (The Low Energy Availability in Females Questionnaire and Low Energy Availability in Males Questionnaire), and eating disorder risk (DESA – 6). College athletes were recruited from Division I and III universities: (N = 31) from the track and …