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Articles 2101 - 2130 of 57463
Full-Text Articles in Entire DC Network
From Asylums To Hospitals To Prisons: The History Of Institutional Psychiatric Care In America, Mary E. Horton
From Asylums To Hospitals To Prisons: The History Of Institutional Psychiatric Care In America, Mary E. Horton
History of Medicine Seminar
No abstract provided.
Direct Effects Of Capsaicin On Voltage-Dependent Calcium Channels Of Mammalian Skeletal Muscle, Dmytro Isaev, Tatiana Prytkova, Badarunnisa Mohamed, Mohamed Omar Mahgoub, Keun-Hang Susan Yang, Murat Oz
Direct Effects Of Capsaicin On Voltage-Dependent Calcium Channels Of Mammalian Skeletal Muscle, Dmytro Isaev, Tatiana Prytkova, Badarunnisa Mohamed, Mohamed Omar Mahgoub, Keun-Hang Susan Yang, Murat Oz
Pharmacy Faculty Articles and Research
Capsaicin, a naturally occurring polyphenol, is known to affect energy expenditure and muscle fatigue and modulate contractions in skeletal muscle. The L-type Ca2+ channels are known to be an important ion channel involved in the various muscle functions and the effect of capsaicin on the skeletal L-type Ca2+ channels is currently unknown. In this study, the effects of capsaicin and capsaicin analogs on depolarization-induced Ca2+ effluxes through L-type Ca2+ channels in transverse tubule membranes from rabbit skeletal muscle and L-type Ca2+ currents recorded using the whole-cell patch clamp technique in rat myotubes were examined. Capsaicin, …
Fda Policy Shift On Clinical Efficacy Study Requirements For Monoclonal Antibody Biosimilars, Rileigh Rahrig, Madilyn Paphanchith, Allie Honigford, Daniella Egbujor, Haley Brown, Jenny Magana Figueroa, Connor Dains, Brenna Hissong, Kyle W. Parker
Fda Policy Shift On Clinical Efficacy Study Requirements For Monoclonal Antibody Biosimilars, Rileigh Rahrig, Madilyn Paphanchith, Allie Honigford, Daniella Egbujor, Haley Brown, Jenny Magana Figueroa, Connor Dains, Brenna Hissong, Kyle W. Parker
Pharmacy and Wellness Review
Biologic products are widely used in the treatment of various disease states, including rheumatoid arthritis, inflammatory bowel disease, cancers, and genetic diseases. These products are derived from proteins and genes produced by living organisms and are subsequently used to treat specific disease states. Due to the complexity of biological products, the costs of research and production are high. Currently, the United States approval pathway requires extensive testing for biologics to be designated as biosimilars, meaning there are no clinically meaningful differences in safety or purity of their active components. These required tests can be redundant, as biosimilars are developed using …
Fda Approval Of The Eversense 365 Continuous Glucose Monitoring System: A New Era In Long-Term Glucose Monitoring, Kiley Devoll, Alexander Defranco, Kennedy Kosikowski, Anna Spalvieri, Macy Davis, Connor Dains, Brenna Hissong, Emily Eddy
Fda Approval Of The Eversense 365 Continuous Glucose Monitoring System: A New Era In Long-Term Glucose Monitoring, Kiley Devoll, Alexander Defranco, Kennedy Kosikowski, Anna Spalvieri, Macy Davis, Connor Dains, Brenna Hissong, Emily Eddy
Pharmacy and Wellness Review
Eversense 365 is an implantable continuous glucose monitoring (CGM) system designed to provide accurate glucose measurements for up to 365 days. Current clinical guidelines recommend CGM use for patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), with evidence demonstrating benefit in patients with T2DM regardless of concurrent insulin use. Healthcare providers play a key role in patient education and are well-positioned to support the adoption of long-term CGM technologies, including Eversense 365. The safety and efficacy of the 365-day CGM have been evaluated across a series of clinical trials, which demonstrate clinically meaningful improvements in …
Tumor-Infiltrating Bacteria Disrupt Cancer Epithelial Cell Interactions And Induce Cell-Cycle Arrest, Jorge Luis Galeano Niño, Falk Ponath, Victor A Ajisafe, Clara R Becker, Andrew G Kempchinsky, Martha A Zepeda-Rivera, Javier A Gomez, Hanrui Wu, Jessica G Terrazas, Heather Bouzek, Elizabeth Cromwell, Pritha Chanana, Matthew Wong, Ashish Damania, Michael G White, Y Nancy You, Scott Kopetz, Nadim J Ajami, Jennifer A Wargo, Christopher D Johnston, Susan Bullman
Tumor-Infiltrating Bacteria Disrupt Cancer Epithelial Cell Interactions And Induce Cell-Cycle Arrest, Jorge Luis Galeano Niño, Falk Ponath, Victor A Ajisafe, Clara R Becker, Andrew G Kempchinsky, Martha A Zepeda-Rivera, Javier A Gomez, Hanrui Wu, Jessica G Terrazas, Heather Bouzek, Elizabeth Cromwell, Pritha Chanana, Matthew Wong, Ashish Damania, Michael G White, Y Nancy You, Scott Kopetz, Nadim J Ajami, Jennifer A Wargo, Christopher D Johnston, Susan Bullman
Faculty, Staff and Student Publications
Tumor-infiltrating bacteria are increasingly recognized as modulators of cancer progression and therapy resistance. We describe a mechanism by which extracellular intratumoral bacteria, including Fusobacterium, modulate cancer epithelial cell behavior. Spatial imaging and single-cell spatial transcriptomics show that these bacteria predominantly localize extracellularly within tumor microniches of colorectal and oral cancers, characterized by reduced cell density, transcriptional activity, and proliferation. In vitro, Fusobacterium nucleatum disrupts epithelial contacts, inducing G0-G1 arrest and transcriptional quiescence. This state confers 5-fluorouracil resistance and remodels the tumor microenvironment. Findings were validated by live-cell imaging, spatial profiling, mouse models, and a 52-patient colorectal cancer cohort. Transcriptomics reveals …
Management Of Difficult Patient Situations, Sangeetha Larsen Mpas, Pa-C
Management Of Difficult Patient Situations, Sangeetha Larsen Mpas, Pa-C
Lynchburg Journal of Medical Science
The purpose of this paper is to provide strategies for clinicians to manage difficult patient interactions. A comprehensive search of PubMed was conducted, identifying articles that identified the root cause of difficult patient interactions and assessed methods for successfully navigating these situations. The term “difficult patient” reflects the interaction of patient behavior, clinician perception, and systemic constraints rather than an inherent patient flaw. Effective management involves reframing difficult behavior as an expression of unmet needs and responding with empathy, active listening, clear boundaries, and collaborative decision-making. System-level strategies reduce patient distress and clinician burnout. Ultimately, the difficult patient represents strained …
Identification Of Cadm1 As An Immunotherapeutic Target And Evaluation Of A Novel Cadm1-Targeting Antibody-Drug Conjugate In Preclinical Osteosarcoma Models, Yifei Wang, Zhongting Zhang, Caterina Longo, Wendong Zhang, Qi Wang, Amer Najjar, Xiangjun Tian, Rossana N Lazcano Segura, Michael E Roth, Jonathan Gill, Douglas J Harrison, Zhaohui Xu, Yanhua Yi, Xin Zhou, Sylvester Jusu, Timothy M Stearns, Steven B Neuhauser, Carol J Bult, Jing Wang, Alexander J Lazar, Richard Gorlick
Identification Of Cadm1 As An Immunotherapeutic Target And Evaluation Of A Novel Cadm1-Targeting Antibody-Drug Conjugate In Preclinical Osteosarcoma Models, Yifei Wang, Zhongting Zhang, Caterina Longo, Wendong Zhang, Qi Wang, Amer Najjar, Xiangjun Tian, Rossana N Lazcano Segura, Michael E Roth, Jonathan Gill, Douglas J Harrison, Zhaohui Xu, Yanhua Yi, Xin Zhou, Sylvester Jusu, Timothy M Stearns, Steven B Neuhauser, Carol J Bult, Jing Wang, Alexander J Lazar, Richard Gorlick
Faculty, Staff and Student Publications
Due to the paucity of validated cell surface osteosarcoma-specific targets, patients with this condition have long been excluded from the benefits of antibody-drug conjugate (ADC) therapy observed in patients with several solid and hematologic malignancies. Our comprehensive surfaceome profiling approach previously identified osteosarcoma-specific cell-surface antigens that are highly expressed in osteosarcomas but minimally expressed in normal tissues. As a result, one such antigen, CADM1, was selected for the generation of an ADC. We tested a CADM1-targeting ADC with a tesirine payload (SG3249) in vitro in osteosarcoma, rhabdomyosarcoma, and neuroblastoma patient-derived xenograft cell lines. In vivo, we tested six CADM1-expressing osteosarcoma …
Prognostic Value Of Baseline Qfr In Single-Vessel Intermediate Coronary Stenosis, Yanfeng Lu, Abdulrahman Alqazzaz, Jasmine Bao, Gary S. Mintz, Jiahao Feng, Yong Zhang, Shanshan Gao, Qiang Song, Feifei Ning, Xin Huang, Ning Guo
Prognostic Value Of Baseline Qfr In Single-Vessel Intermediate Coronary Stenosis, Yanfeng Lu, Abdulrahman Alqazzaz, Jasmine Bao, Gary S. Mintz, Jiahao Feng, Yong Zhang, Shanshan Gao, Qiang Song, Feifei Ning, Xin Huang, Ning Guo
Student Papers, Posters & Projects
BACKGROUND AND OBJECTIVES: The prognostic value of baseline Quantitative Flow Ratio (QFR) in real-world patients remains unclear. This study aimed to evaluate the prognostic value of baseline QFR and its three-tier model-low, grey-zone, and high QFR-in patients with single-vessel intermediate stenosis.
METHODS: This retrospective study included 478 patients with QFR between 0.70 and 0.90 who underwent coronary angiography between May and June 2023. Patients were stratified into Low (0.70-0.74), Grey-Zone (0.75-0.85), and High (0.86-0.90) QFR groups. The primary endpoint was major adverse cardiac events (MACE); the key secondary endpoint was target vessel failure (TVF). Kaplan-Meier and Cox proportional hazards models …
Daily Locomotor Activity Declines With Tumor Growth And Disease Progression In Glioblastoma, Maria F Gonzalez-Aponte, Sofia V Salvatore, Anna R. Damato, Ruth Gn Katumba, Grayson R. Talcott, Omar H. Butt, Jian L. Campian, Jingqin Luo, Joshua B. Rubin, Olivia J. Walch, Erik D. Herzog
Daily Locomotor Activity Declines With Tumor Growth And Disease Progression In Glioblastoma, Maria F Gonzalez-Aponte, Sofia V Salvatore, Anna R. Damato, Ruth Gn Katumba, Grayson R. Talcott, Omar H. Butt, Jian L. Campian, Jingqin Luo, Joshua B. Rubin, Olivia J. Walch, Erik D. Herzog
2020-Current year OA Pubs
Glioblastoma (GBM) is an aggressive brain tumor that often progresses despite resection and treatment. Timely and continuous assessment of GBM progression is critical to expedite secondary surgery or enrollment in clinical trials. However, current progression detection requires costly and specialized MRI examinations, which, in the absence of new symptoms or signs, are usually scheduled every 2-3 months. Here, we hypothesized that changes in daily activity are associated with GBM growth and disease progression. We found that wheel-running activity in GBM-bearing mice declined as tumors grew and preceded weight loss and circadian breakdown by over a week. Temozolomide treatment in the …
The Yeh Pilus Adhesin Is Equipped With An Α-Helical Flap Motif, Which Contributes To Pectin Adherence, Kevin O Tamadonfar, Roger D Klein, Edward D B Lopatto, Maxwell I Zimmerman, Philippe N Azimzadeh, Denise A Sanick, Justin R Porter, Jesus Bazan Villicana, Jerome S Pinkner, Bo Huey Chiang, Nathaniel C Gualberto, Karen W Dodson, Michael L Patnode, George M H Et Al., Gregory R Bowman, Scott J Hultgren
The Yeh Pilus Adhesin Is Equipped With An Α-Helical Flap Motif, Which Contributes To Pectin Adherence, Kevin O Tamadonfar, Roger D Klein, Edward D B Lopatto, Maxwell I Zimmerman, Philippe N Azimzadeh, Denise A Sanick, Justin R Porter, Jesus Bazan Villicana, Jerome S Pinkner, Bo Huey Chiang, Nathaniel C Gualberto, Karen W Dodson, Michael L Patnode, George M H Et Al., Gregory R Bowman, Scott J Hultgren
2020-Current year OA Pubs
The Yeh chaperone-usher pathway (CUP) pilus adhesin is encoded in one-half of all
Maternal Immunization With Vp8* Mrna Vaccine Yields Superior Passive Transfer Of Rotavirus-Neutralizing Antibodies To Foals, Karin E R Borba, Rebecca M Legere, Nathan M Canaday, Jill W Skrobarczyk, Zachary W T Arnold, Elena Cotton-Betteridge, Cristina Poveda, Michael F Criscitiello, Angela I Bordin, Luc R Berghman, Jeroen B K Pollet, Noah D Cohen
Maternal Immunization With Vp8* Mrna Vaccine Yields Superior Passive Transfer Of Rotavirus-Neutralizing Antibodies To Foals, Karin E R Borba, Rebecca M Legere, Nathan M Canaday, Jill W Skrobarczyk, Zachary W T Arnold, Elena Cotton-Betteridge, Cristina Poveda, Michael F Criscitiello, Angela I Bordin, Luc R Berghman, Jeroen B K Pollet, Noah D Cohen
Faculty, Staff and Students Publications
Background: Despite the availability of a killed whole-virus (KV) vaccine, diarrhea caused by equine rotavirus group A (ERVA) remains a significant health concern for foals in the United States. The vaccine is administered to pregnant mares, with foals protected by passive transfer of colostral antibodies. However, KV-induced immunity is only partially protective and maternal antibody levels in foals are often low and wane rapidly. To address these limitations, we developed a mRNA-based ERVA vaccine encoding the highly conserved VP8* protein to evaluate whether it can provide improved immune protection.
Methods: Pregnant mares (n = 12 per group) were …
Assessment Of Body Fat Percentage In Emirati Females: A Comparative Analysis Of Bia Vs. Dxa, Dalia Haroun, Aseel Ehsanallah
Assessment Of Body Fat Percentage In Emirati Females: A Comparative Analysis Of Bia Vs. Dxa, Dalia Haroun, Aseel Ehsanallah
All Works
Introduction: Obesity is a significant health issue in the UAE. Accurate body composition assessment is crucial for managing obesity-related health risks. This study aimed to evaluate the agreement between bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) in measuring body composition among Emirati females. Methods: This cross-sectional study involved 95 healthy Emirati females aged 17–27 years. Paired samples t-tests, correlation analyses, and Bland-Altman plots were used to compare the two methods (BIA vs. DXA). Results: BIA significantly underestimated % fat and fat mass (FM) while overestimating fat-free mass (FFM) compared to DXA. The mean difference in % fat was …
Knowledge And Practice Of Breast Self-Examination Among Young Women Comes To General Surgery Clinic In Shebin El Kom Teaching Hospital, Shimaa M W Kalama
Knowledge And Practice Of Breast Self-Examination Among Young Women Comes To General Surgery Clinic In Shebin El Kom Teaching Hospital, Shimaa M W Kalama
Journal of Medicine in Scientific Research
Background Breast cancer, which makes up 30.4% of newly diagnosed tumors, is one of the most common cancers among young girls. Every woman who is 20 years of age or older is thought to be at risk of getting breast cancer. This research is crosssectional. The Shebin-Elkom Teaching Hospital served as the study's site. Randomized sampling was used to enroll five hundred women for this study. To collect information, a self-administration questionnaire was employed. Objective:. to evaluate the women who visited the surgery clinic at Shebin El Kom Teaching Hospital's knowledge of breast cancer, BSE, and its function in early …
Developing A Multidisciplinary Approach To Complex Pediatric Areodigestive Care- Where We've Been, Where We're Going, And What We've Learned Along The Way, Jason R. Brown
Grand Rounds
- Enhance competence and expand expertise in pediatric surgical conditions prevalent in our geographical area and nationally.
- Develop strategies to enhance communication and collaboration among interdisciplinary team members addressing pediatric surgical conditions.
- List barriers to multidisciplinary care.
Novel Repurposing Of Empagliflozin-Loaded Buccal Composite (Chitosan/Silk Fibroin/Poly(Lactic Acid)) Nanofibers For Alzheimer’S Disease Management Via Modulation Of Aβ–Ager–P-Tau Pathway, Samar A. Salim
Nanotechnology Research Centre
Background/Objectives: Empagliflozin (EMPA) was repurposed for Alzheimer’s disease (AD) treatment via buccal delivery, exploiting novel nanofibers (NFs) integrating chitosan (Cs), silk fibroin (Fb), and poly(lactic acid) (PLA). Methods: EMPA-loaded Cs/Fb/PLA NFs were electrospun in different formulations to optimize the formulation parameters. The optimized formulation was then investigated for its enhanced in vivo effect. Results: Optimized nanofiber diameters ranged from 459 ± 173 to 668 ± 148 nm, possessing bead-free morphology confirmed by SEM and satisfactory mechanical properties. EMPA was successfully well-dispersed in the polymer matrix as evidenced by FTIR, XRD, and drug content. The optimized NFs displayed a hydrophilic surface …
Gh Alters Lymphatic Vessels In Female Mice And Stat5 Phosphorylation In Human Lymphatic Endothelial Cells, Christopher Walsh, Emily Scott, Elise Wagner, Jerome Walsh, Shashank Reddy, Arshad Ahmad, Reetobrata Basu, Eva Sevick-Muraca, Rich Brody, Uday Sandbhor, Sebastian Neggers, John J Kopchick
Gh Alters Lymphatic Vessels In Female Mice And Stat5 Phosphorylation In Human Lymphatic Endothelial Cells, Christopher Walsh, Emily Scott, Elise Wagner, Jerome Walsh, Shashank Reddy, Arshad Ahmad, Reetobrata Basu, Eva Sevick-Muraca, Rich Brody, Uday Sandbhor, Sebastian Neggers, John J Kopchick
The Brown Foundation: Institute of Molecular Medicine
Disruption of lymphatic function underlies a broad spectrum of inflammatory and metabolic disorders, yet the hormonal pathways that regulate lymphatic biology remain poorly defined. GH, which is implicated in similar disease states, has an unclear role in lymphatic homeostasis. To address this gap, we investigated how chronic alterations in GH signaling alter lymphatic structure and function. Using transgenic mouse lines with increased, decreased, or absent GH action, we quantified the effect of GH on lymphatic pumping rate and lymphangiogenic remodeling during wound healing using near-infrared fluorescent imaging. We also measured markers of lymphatic endothelial cells using Western blot and immunohistochemistry …
Predictors Of Caregiver Burden Among The Caregivers Of Bedridden Patients In Muscat, Oman, Rawan Al Abdulsalam, Hajer Al Shaaibi, Manar Al Sanaa Al Zeedi, Rahma Al Hadhrami
Predictors Of Caregiver Burden Among The Caregivers Of Bedridden Patients In Muscat, Oman, Rawan Al Abdulsalam, Hajer Al Shaaibi, Manar Al Sanaa Al Zeedi, Rahma Al Hadhrami
Sultan Qaboos University Medical Journal
Objectives: Caring for bedridden patients is physically and emotionally demanding, often resulting in significant caregiver burden. This study aimed to assess caregiver burden and associated factors among caregivers of adult bedridden patients in Muscat, Oman. Methods: This cross-sectional study was conducted from January 2024 to February 2025 among caregivers of adult bedridden patients registered to get community services in Muscat Governorate and provided care for more than 1 month. Data were collected using the 12-item Zarit Burden Interview and the Katz Index of Independence in Activities of Daily Living. Results: A total of 200 caregivers participated; 66% were female, with …
Assessing The Effects Of Ehealth Literacy And The Area Deprivation Index On Barriers To Electronic Patient Portal Use For Orthopedic Surgery: Cross-Sectional Observational Study, Audrey Lynn Litvak, Nicholas Lin, Kelly Hynes, Jason Strelzow, Jeffrey G Stepan
Assessing The Effects Of Ehealth Literacy And The Area Deprivation Index On Barriers To Electronic Patient Portal Use For Orthopedic Surgery: Cross-Sectional Observational Study, Audrey Lynn Litvak, Nicholas Lin, Kelly Hynes, Jason Strelzow, Jeffrey G Stepan
2020-Current year OA Pubs
BACKGROUND: As electronic patient portals (EPPs) continue to gain popularity and systems transition to online tools for scheduling, communication, and telehealth, patients without access or skills to use these tools may be overlooked.
OBJECTIVE: This study analyzed patient and neighborhood-level factors, including eHealth literacy level and the Area Deprivation Index (ADI), that may limit EPP access for orthopedic surgery.
METHODS: A cross-sectional, survey-based study was performed at a single urban tertiary academic medical center in the United States across foot and ankle, hand and upper extremity, and orthopedic trauma subspecialty clinics from June 21, 2022, to August 12, 2022. Survey …
Cancer Literacy And Social Determinants Of Health: An Epidemiological Analysis Of Trust, Digital Engagement, And Healthcare Utilization In Cancer Information Seeking, Kimberly Leeann Hazel
Cancer Literacy And Social Determinants Of Health: An Epidemiological Analysis Of Trust, Digital Engagement, And Healthcare Utilization In Cancer Information Seeking, Kimberly Leeann Hazel
Walden Dissertations and Doctoral Studies
The rise of online health information has increased access to cancer resources but also amplified misinformation, creating trust gaps that threaten prevention, treatment, and health equity. This study examined how trust in cancer information sources, online information-seeking, and healthcare perceptions relate among U.S. adults. Guided by the health information seeking behavior, the socioecological model, and the structural influence model of health communication, data from the 2022 Health Information National Trends Survey (N = 6,197) were analyzed with logistic regression, mediation, and moderation modeling, controlling for demographics. Trust in government agencies predicted greater cancer information seeking (odds ratio [OR] = 1.94, …
Harnessing Microbial Tools: Escherichia Coli As A Vehicle For Neuropeptide Functional Analysis In Caenorhabditis Elegans, Elizabeth M Diloreto, Shruti Shastry, Emily J Leptich, Douglas K Reilly, Rachel N Arey, Jagan Srinivasan
Harnessing Microbial Tools: Escherichia Coli As A Vehicle For Neuropeptide Functional Analysis In Caenorhabditis Elegans, Elizabeth M Diloreto, Shruti Shastry, Emily J Leptich, Douglas K Reilly, Rachel N Arey, Jagan Srinivasan
Faculty, Staff and Students Publications
Animals respond to changes in their environment and internal states via neuromodulation. Neuropeptides modulate neural circuits with flexibility because 1 gene can produce either multiple copies of the same neuropeptide or different neuropeptides. However, with this architectural complexity, the function of discrete and active neuropeptides is muddled. Here, we design a genetic tool that facilitates functional analysis of individual peptides. We engineered Escherichia coli bacteria to express active peptides, fed loss-of-function Caenorhabditis elegans, and rescued the activity of genes with varying lengths and functions: pdf-1, flp-3, ins-6, and ins-22. Some peptides were functionally redundant, while others exhibit unique and previously …
National Survey Of Physical Therapists’ Participation As Health Educators In Physical Activity Promotion Among Older Adults, Casey Nicole Mokres
National Survey Of Physical Therapists’ Participation As Health Educators In Physical Activity Promotion Among Older Adults, Casey Nicole Mokres
Walden Dissertations and Doctoral Studies
Physical inactivity among older adults remains a major national and global public health concern linked to preventable morbidity, mortality, and rising healthcare costs. Physical therapists are uniquely positioned to promote physical activity (PA) through health education, yet their engagement in this role is not well defined. This quantitative cross-sectional study examined associations between clinical practice factors—years of experience, board certification status, and practice setting—and three domains of the theoretical domains framework (knowledge, skills, and behavioral regulation) related to PA promotion among older adults. The framework guided identification of behavioral and contextual factors influencing therapists’ delivery of PA promotion interventions. Data …
Ai Companions And Adolescent Social Relationships: Benefits, Risks, And Bidirectional Influences, Xiaoran Sun, Yunqi Wang, Brandon Mcdaniel
Ai Companions And Adolescent Social Relationships: Benefits, Risks, And Bidirectional Influences, Xiaoran Sun, Yunqi Wang, Brandon Mcdaniel
Health Services and Informatics Research
AI companions (AI-Cs)—rapidly emerging conversational agents built on large language models that can provide personalized humanlike companionship—create unprecedented opportunities for adolescents to form emotional bonds with nonhuman entities during a critical period for social development. In this article, we discuss the interplay between adolescents' use of AI-Cs and their social relationships based on theoretical hypotheses driving research on digital communication and adolescent well-being. We explore the benefits and risks of AI-Cs to social development based on the stimulation hypothesis and the displacement hypothesis: AI-Cs can provide safe spaces for identity exploration and emotional expression, potentially building skills that transfer to …
Defective Dna Damage Response Is A Targetable Therapeutic Vulnerability In Esr1 Mutant Breast Cancer, Sarah K Herzog, Jessica H Stevens, Guowei Gu, Sandra L Grimm, Kloma Cardoza, Autumn G M Hawkins, Hangqing Lin, Daniela Ramos, Amanda R Beyer, David G Edwards, Derek Dustin, Harry J Yang, Nicole Liang, Ashfia F Khan, Tasneem Bawa-Khalfe, Daniel J Mcgrail, Shiaw-Yih Lin, Cristian Coarfa, Suzanne A W Fuqua
Defective Dna Damage Response Is A Targetable Therapeutic Vulnerability In Esr1 Mutant Breast Cancer, Sarah K Herzog, Jessica H Stevens, Guowei Gu, Sandra L Grimm, Kloma Cardoza, Autumn G M Hawkins, Hangqing Lin, Daniela Ramos, Amanda R Beyer, David G Edwards, Derek Dustin, Harry J Yang, Nicole Liang, Ashfia F Khan, Tasneem Bawa-Khalfe, Daniel J Mcgrail, Shiaw-Yih Lin, Cristian Coarfa, Suzanne A W Fuqua
Faculty, Staff and Student Publications
ESR1 mutations are the leading cause of endocrine therapy resistance and progression in ER-positive metastatic breast cancer. ESR1 mutations are detected in ~50% of metastatic breast cancer patients, and identification of effective targeted therapeutics are critically needed. Here, we identified enrichment of dysregulated replication stress and DNA damage responses in multiple ESR1 mutant models. Targeting the replication stress response utilizing checkpoint inhibition in combination with PARP inhibition synergistically suppressed growth, induced cell cycle arrest, and attenuated DNA replication. PARP inhibition blocked metastatic dissemination in vivo and reduced both PARP1 and ER-regulated protein expression. PARP trapping by olaparib treatment with or …
Perceived Academic Workload And Well-Being Among Radiologic Technology Students During Home-Based Learning, Alvin Diaz Crudo
Perceived Academic Workload And Well-Being Among Radiologic Technology Students During Home-Based Learning, Alvin Diaz Crudo
The Lasallian Journal of Health
Introduction: COVID-19 disrupted educational delivery worldwide, forcing Higher Education Institutions (HEIs) to shift to home-based learning modalities combining synchronous and asynchronous modes. Radiologic technology students' academic workload intensified with digital and non-digital activities, requiring stronger internet connectivity amid barriers like stress and burnout. This study determined the correlation between perceived academic workload and well-being among third-year radiologic technology students at De La Salle Medical and Health Sciences Institute during home-based learning. Methods: A correlational research design was employed with 124 of 136 students (91.18%) participating during A.Y. 2021-2022. Researchers used self-made questionnaires based on Bowyer's (2012) "Student Workload Model" and …
Factors Affecting The Colony Count Of Oral Candida Albicans Of Electronic Cigarette Users Among Young Adults In Dasmariñas, Cavite, Kyla Marie C. Resuma, Rendell B. Rovelo, Martella Ingrid A. Sanchez, Christine Joy R. Sobiono, Michaela Marie N. Tena, Gabriel C. Villota
Factors Affecting The Colony Count Of Oral Candida Albicans Of Electronic Cigarette Users Among Young Adults In Dasmariñas, Cavite, Kyla Marie C. Resuma, Rendell B. Rovelo, Martella Ingrid A. Sanchez, Christine Joy R. Sobiono, Michaela Marie N. Tena, Gabriel C. Villota
The Lasallian Journal of Health
Electronic cigarettes (e-cigarettes) emerged and were marketed as a more viable alternative to traditional tobacco smoking, especially among the youth. While there is insufficient evidence clearly explaining the effects of e-cigarette use on human health, recent literature has shone light on its various adverse effects on the body, particularly on oral health and its possible contribution to oral microbial dysbiosis. This study explored the potential factors that may have affected the colony counts of oral Candida albicans—the causative agent of thrush. The study participants (N = 40) comprised 22 male and 18 female e-cigarette users aged 18 to 22 …
Factors Affecting The Level Of Grief Experienced By Men Whose Female Partner Died In The United States, Keona C. Lee
Factors Affecting The Level Of Grief Experienced By Men Whose Female Partner Died In The United States, Keona C. Lee
Walden Dissertations and Doctoral Studies
Grief is an emotional reaction to the loss of a loved one through death. Although grief is a universal human experience, its perspective is unique, and research has often ignored the varied experiences of racial/ethnic and cultural groups, particularly men of color in the United States. The purpose of this quantitative study was to measure the level of grief experienced by men whose female partner died and to determine whether ethnicity, having a prior mental health diagnosis, social support, and traumatic or anticipated loss significantly impacted their level of grief. The study was guided by the social-ecological model to explain …
Rapid Inpatient Methadone Induction In The Fentanyl Era: A Systematic Review Of Safety, Efficacy, And Protocols For Hospitalized Patients With Opioid Use Disorder, Lorik Berisha, Sapan Patel, Charlotte Pirquet, Navina Magesh Kumar, Yousef Soliman, Ahsan Ullah, Daniel M. Matassa
Rapid Inpatient Methadone Induction In The Fentanyl Era: A Systematic Review Of Safety, Efficacy, And Protocols For Hospitalized Patients With Opioid Use Disorder, Lorik Berisha, Sapan Patel, Charlotte Pirquet, Navina Magesh Kumar, Yousef Soliman, Ahsan Ullah, Daniel M. Matassa
Division of Internal Medicine Faculty Papers & Presentations
Purpose of Review: The potency of illicit fentanyl has rendered standard methadone inductions inadequate for many hospitalized adults with opioid use disorder. Standard protocols often fail to achieve therapeutic doses quickly enough to manage withdrawal and cravings in fentanyl-tolerant individuals, contributing to poor retention and higher self-discharge rates. This review examines emerging evidence on dosing strategies, outcomes, and safety of rapid methadone inductions in acute-care hospitals. Recent Findings: Nine studies (five retrospective cohorts, four case series/reports) encompassing 380 patients met inclusion criteria. Median starting doses were 30–40 mg (range 20–90 mg), with daily or symptom-triggered increases achieving 60–100 mg within …
Saudi Heart Association Position Statement On Early Detection Of Subclinical Atherosclerosis In Clinical Practice, Waleed Alhabeeb, Abdelrahaman Almoghairi, Abdulhalim Kinsara, Abdullah Khoja
Saudi Heart Association Position Statement On Early Detection Of Subclinical Atherosclerosis In Clinical Practice, Waleed Alhabeeb, Abdelrahaman Almoghairi, Abdulhalim Kinsara, Abdullah Khoja
Journal of the Saudi Heart Association
Background: Atherosclerosis is the leading underlying cause of cardiovascular disease (CVD), which remains the primary cause of mortality in Saudi Arabia. Saudi patients experience CVD events nearly a decade earlier than their Western counterparts. Given the limitations of traditional risk assessment tools, there is a growing need to detect subclinical atherosclerosis to refine risk stratification and improve primary prevention strategies, particularly in younger and asymptomatic individuals.
Methods: The Saudi Heart Association (SHA) developed this position statement through a structured, multistep process that included a comprehensive literature review and two expert panel meetings. Recommendations were formulated based on current evidence, expert …
Trends In The Implementation Of The Cyberchondria Severity Scale: Bibliometric Analysis, Adam C Powell, Cayetana Calderon-Smith
Trends In The Implementation Of The Cyberchondria Severity Scale: Bibliometric Analysis, Adam C Powell, Cayetana Calderon-Smith
College of Population Health Faculty Papers
BACKGROUND: Cyberchondria, a combination of the words "cyber" and "hypochondriasis," is a condition that is receiving increasing attention from clinicians and researchers globally. Researchers are currently using multiple instruments to quantify it. Furthermore, the instruments have been translated into multiple languages.
OBJECTIVE: This study aimed to examine the extent to which researchers are measuring cyberchondria using the 33-item Cyberchondria Severity Scale (CSS) and its 12-item abbreviated version, the CSS-12. It also examined the relative use of cyberchondria instruments in different languages.
METHODS: PubMed and PsycInfo were searched for articles published between May 1, 2019, and December 31, 2024, featuring the …
M-O-M-S On The Bayou: Implementation Of An Intervention To Improve Mental Health After Disaster, E. W. Harville, Gloria Giarratano, M. Patterson, M. Schultheis, K. S. Dorans, S. Turner, S. Harris, S. Longo, K. Weis
M-O-M-S On The Bayou: Implementation Of An Intervention To Improve Mental Health After Disaster, E. W. Harville, Gloria Giarratano, M. Patterson, M. Schultheis, K. S. Dorans, S. Turner, S. Harris, S. Longo, K. Weis
School of Nursing Faculty Publications
Pregnant women are a vulnerable population after disaster. Their health may be improved through community-based support programs in addition to their standard prenatal care. We conducted a prenatal peer support program, Mentors Offering Maternal Support (M-O-M-S), focused on improving mental health in hurricane-affected areas in southern Louisiana. M-O-M-S consists of six biweekly sessions covering pregnancy acceptance, maternal role identification, family and partner relationships, preparation for labor/fears around labor, well-being/safety of self and baby, and post-delivery health and maternal-infant bonding. The program is led by a “mentor”, an experienced mother but not necessarily a clinician or social worker, who guides the …