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Association Between Frailty Status And Pain, Balance, And Quality Of Life In Patients With Lumbar Spinal Stenosis, Musa Güneş, Aydin Si̇nan Apaydin Feb 2026

Association Between Frailty Status And Pain, Balance, And Quality Of Life In Patients With Lumbar Spinal Stenosis, Musa Güneş, Aydin Si̇nan Apaydin

Turkish Journal of Medical Sciences

Background/aim: Frailty is a clinical syndrome that affects individuals physically and psychosocially. However, the association between lumbar spinal stenosis (LSS) and frailty remains unclear. This study aimed to compare pain, balance, disability, fear of falling, and quality of life between patients with LSS with and without frailty.

Materials and methods: This cross-sectional study included 43 frail and 48 nonfrail patients with LSS according to the frailty criteria of Fried et al. Pain intensity (numeric rating scale [NRS]), static balance (single leg stance test [SLST]), dynamic balance (Timed Up and Go test [TUG]), disability (Oswestry Disability Index [ODI]), fear of falling …


The Impact Of Covid-19 On Healthcare Workers: Risk Factors, Sources Of Infection, And Sickness Absenteeism, Ezgi̇ Gülten, Güle Çinar, İrem Akdemi̇r, Eli̇f Muki̇me Saricaoğlu, İlkay Taşdan, Emi̇ne Atmaca, Si̇bel Kaymakçi, Fatma Şanal, Di̇lek Sevi̇m Akdaş, Arzu Büyüm, Gülşah Kocaali̇, Safi̇ye Tarakçi, Ati̇lla Hali̇l Elhan, Mehmet Serhat Bi̇rengel, Kemal Osman Memi̇koğlu, Alpay Azap Feb 2026

The Impact Of Covid-19 On Healthcare Workers: Risk Factors, Sources Of Infection, And Sickness Absenteeism, Ezgi̇ Gülten, Güle Çinar, İrem Akdemi̇r, Eli̇f Muki̇me Saricaoğlu, İlkay Taşdan, Emi̇ne Atmaca, Si̇bel Kaymakçi, Fatma Şanal, Di̇lek Sevi̇m Akdaş, Arzu Büyüm, Gülşah Kocaali̇, Safi̇ye Tarakçi, Ati̇lla Hali̇l Elhan, Mehmet Serhat Bi̇rengel, Kemal Osman Memi̇koğlu, Alpay Azap

Turkish Journal of Medical Sciences

Background/aim: Healthcare workers (HCWs) face increased risks of COVID-19 infection due to occupational exposure. Understanding infection sources, risk factors, and workforce losses is crucial for mitigating these impacts in future pandemics. This study aimed to evaluate the risk factors, infection sources, and sickness absenteeism among HCWs diagnosed with SARS-CoV-2 infection, providing insights to enhance infection control strategies.

Materials and methods: The study included 2153 HCWs diagnosed with SARS-CoV-2 between March 2020 and February 2023 at a tertiary care hospital in Türkiye. Demographic, clinical, and professional characteristics, personal protective equipment (PPE) usage, infection sources, and vaccination data were analyzed. Statistical analyses …


Involvement Of Swap-70 In Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis, Canan Ulusoy, Gi̇zem Koral, Fatma Akpunar Salman, Meli̇s Şen, Emi̇ne Şekerdağ Kiliç, Recai̇ Türkoğlu, Cem İsmai̇l Küçükali̇, Yasemi̇n Gürsoy Özdemi̇r, Vuslat Yilmaz, Erdem Tüzün Feb 2026

Involvement Of Swap-70 In Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis, Canan Ulusoy, Gi̇zem Koral, Fatma Akpunar Salman, Meli̇s Şen, Emi̇ne Şekerdağ Kiliç, Recai̇ Türkoğlu, Cem İsmai̇l Küçükali̇, Yasemi̇n Gürsoy Özdemi̇r, Vuslat Yilmaz, Erdem Tüzün

Turkish Journal of Medical Sciences

Background/aim: Multiple sclerosis (MS) is a chronic demyelinating inflammatory disease of the central nervous system. Studies have shown that B cells may play an important role in the induction and progression of MS. Switch-associated protein 70 (SWAP-70) is a signal transduction molecule abundantly expressed in B cells and involved in B-cell polarization, directed migration, endothelial cell adhesion, and tissue homing. B-cell stimuli increase its expression. SWAP-70 has been implicated in the pathogenesis of autoimmune disorders, including MS. This study aims to investigate the effects of acquired SWAP-70 inhibition on immune cell subsets in experimental autoimmune encephalomyelitis (EAE).

Materials and methods: …


Oleanolic Acid–Chitosan Compound Inhibits Mitochondrial Autophagy And Malignant Transformation Of Lung Cancer Through The Pten/Akt Pathway, Abuli̇mi̇ti̇ Abulai̇ti̇, Xi̇aohong Sun, Waresijiang Yibulayin, Dan He, Kemi̇ng Xu, Xi̇ayi̇mai̇erdan Yi̇bulayi̇n Feb 2026

Oleanolic Acid–Chitosan Compound Inhibits Mitochondrial Autophagy And Malignant Transformation Of Lung Cancer Through The Pten/Akt Pathway, Abuli̇mi̇ti̇ Abulai̇ti̇, Xi̇aohong Sun, Waresijiang Yibulayin, Dan He, Kemi̇ng Xu, Xi̇ayi̇mai̇erdan Yi̇bulayi̇n

Turkish Journal of Medical Sciences

Background/aim: Oleanolic acid–chitosan compound (OAC) shows potent antinonsmall cell lung cancer (NSCLC) activity, but its mechanisms remain unclear. This study elucidates how OAC modulates autophagy and apoptosis via the Phosphatase and Tensin Homolog/Protein Kinase B (PTEN/AKT) signaling pathway.

Materials and methods: Oleanolic acid was coupled with chitosan to synthesize OAC. A549 and MRC-5 cells were cultured in Dulbecco’s Modified Eagle Medium and Minimum Essential Medium, respectively, supplemented with 10% fetal bovine serum and penicillin–streptomycin. Cells were pretreated with chloroquine before OAC treatment. Cell viability was assessed using the CCK- 8 assay, while 5-bromo-2′-deoxyuridine (BrdU) and colony formation tests were employed …


The Prevalence And Impact Of Workplace Violence In Community Pharmacies: A Mixed-Methods Study, Hi̇lal İlbars, Berna Terzi̇oğlu Bebi̇toğlu, Seyhan Hidiroğlu, Fatma Burcu Doğanç, Yağiz Varol Feb 2026

The Prevalence And Impact Of Workplace Violence In Community Pharmacies: A Mixed-Methods Study, Hi̇lal İlbars, Berna Terzi̇oğlu Bebi̇toğlu, Seyhan Hidiroğlu, Fatma Burcu Doğanç, Yağiz Varol

Turkish Journal of Medical Sciences

Background/aim: Pharmacists and pharmacy technicians employed in community pharmacies face a considerable risk of workplace violence, which can negatively influence their job satisfaction, productivity, and mental well-being. This study examined the prevalence and consequences of workplace violence in community pharmacies in Ankara through a mixed-methods design integrating cross-sectional survey data with qualitative insights.

Materials and methods: The target population included pharmacists and pharmacy technicians. We examined demographic factors, psychological outcomes, and the nature of violent incidents. Data were obtained from a random sample of 355 community pharmacies using a 39-item survey and the depression anxiety stress scales (DASS-21), complemented by …


Preventing Spinal Muscular Atrophy Through The National Premarital Screening Program In Türkiye: An Economic Comparison With Treatment Costs, Gamze Dur, Gülcan Teci̇rli̇, Nurullah Okumuş Feb 2026

Preventing Spinal Muscular Atrophy Through The National Premarital Screening Program In Türkiye: An Economic Comparison With Treatment Costs, Gamze Dur, Gülcan Teci̇rli̇, Nurullah Okumuş

Turkish Journal of Medical Sciences

Background/aim: Spinal muscular atrophy (SMA) is a severe neuromuscular disorder with high treatment costs and significant psychosocial burden. In 2021, Türkiye launched a national premarital SMA carrier screening program integrated with in vitro fertilization (IVF) with preimplantation genetic testing (PGT) services for couples identified as carriers. This study aimed to compare the costs associated with the carrier screening and prevention program versus a no-screening (treatment-only) scenario.

Materials and methods: A cost comparison model was developed using data from the Turkish Statistical Institute, the Ministry of Health, and the Social Security Institution. The annual costs of SMA treatment (with nusinersen and …


Contribution Of Adenosine A2a Receptor Agonist And Antagonist On Ovarian Ischemia/Reperfusion Injury In Rats, Azad Mammadov, Abdullah Tuncay Demi̇ryürek, Ahmet Saracaloğlu, Cahi̇t Demi̇rkiran, İsmai̇l Tuncer Deği̇m, Ömer Eronat, Şeni̇z Demi̇ryürek Feb 2026

Contribution Of Adenosine A2a Receptor Agonist And Antagonist On Ovarian Ischemia/Reperfusion Injury In Rats, Azad Mammadov, Abdullah Tuncay Demi̇ryürek, Ahmet Saracaloğlu, Cahi̇t Demi̇rkiran, İsmai̇l Tuncer Deği̇m, Ömer Eronat, Şeni̇z Demi̇ryürek

Turkish Journal of Medical Sciences

Background/aim: To determine the effects of an A2A receptor agonist regadenoson, an A2A receptor antagonist istradefylline, and istradefylline nanosuspension on ovarian ischemia/reperfusion (I/R) injury in rats.

Materials and methods: A total of 80 female rats were divided into 10 groups: sham, ovarian I/R, blank nanosuspension + ovarian I/R, regadenoson (3 μg/kg) + ovarian I/R, regadenoson (30 μg/kg) + ovarian I/R, istradefylline (0.3 mg/kg) + ovarian I/R, istradefylline (3 mg/kg) + ovarian I/R, istradefylline-loaded nanosuspension (3 mg/kg) + ovarian I/R, istradefylline (3 mg/kg) + regadenoson (30 μg/kg) + ovarian I/R, and istradefylline-loaded nanosuspension (3 mg/kg) + regadenoson (30 μg/kg) + ovarian …


Assessing The Influence Of Third Molar Classification On The Risk Of Caries In Adjacent Teeth, Si̇nan Yasi̇n Ertem, Fati̇h Doğanoğlu, Fehi̇me Alkan Aygör Feb 2026

Assessing The Influence Of Third Molar Classification On The Risk Of Caries In Adjacent Teeth, Si̇nan Yasi̇n Ertem, Fati̇h Doğanoğlu, Fehi̇me Alkan Aygör

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the relationship between the impaction level and angulation of third molars and the incidence of caries in the adjacent second molars.

Materials and methods: A total of 690 panoramic radiographs obtained from patients at Ankara Yıldırım Beyazıt University between May 2022 and January 2024 were retrospectively analyzed. Third molars were classified based on their eruption status using the Pell and Gregory classification (levels A, B, and C), and angulation (mesioangular, distoangular, vertical, horizontal, and inverted). The presence of caries in adjacent second molars was assessed using the international caries detection and assessment system/international caries …


Tumor-Immune-Neural Circuit Disrupts Energy Homeostasis In Cancer Cachexia, Xiuhui Shi, Alex X Arreola, Zhijun Zhou, Jingxuan Yang, Mingyang Liu, Yang Cai, Yu Ren, Hao Yuan, Qun Chen, Xinjie Chen, Xinyu Yang, Yimei Meng, Jingyi Wang, Wenyi Luo, Michael C Rudolph, Rohan Varshney, Kar-Ming Fung, Chao Xu, Wei R Chen, Michael S Bronze, Lei Zheng, Yi-Ping Li, Courtney W Houchen, Yuqing Zhang, Min Li Feb 2026

Tumor-Immune-Neural Circuit Disrupts Energy Homeostasis In Cancer Cachexia, Xiuhui Shi, Alex X Arreola, Zhijun Zhou, Jingxuan Yang, Mingyang Liu, Yang Cai, Yu Ren, Hao Yuan, Qun Chen, Xinjie Chen, Xinyu Yang, Yimei Meng, Jingyi Wang, Wenyi Luo, Michael C Rudolph, Rohan Varshney, Kar-Ming Fung, Chao Xu, Wei R Chen, Michael S Bronze, Lei Zheng, Yi-Ping Li, Courtney W Houchen, Yuqing Zhang, Min Li

Faculty, Staff and Student Publications

Cancer-induced cachexia and anorexia are debilitating complications across many cancers, yet effective treatments remain limited due to a poor understanding of the underlying mechanisms. Here, we identify an uncharacterized tumor-immune-neural circuit driving these syndromes, centered on growth and differentiation factor 15 (GDF15). Using genetically engineered mouse models, we find that loss of GDF15 protects against appetite loss, muscle wasting, and fat loss in pancreatic, lung, and skin cancers. Single-cell RNA sequencing reveals macrophages as a major source of GDF15, induced by tumor-derived colony-stimulating factor 1 (CSF1). GDF15 acts via the central nervous system to enhance β-adrenergic signaling in the tumor …


Targeting Oxalate Production By Combining Enzyme Inhibition And Proteolysis Activation: A Novel Therapeutic Approach For Primary Hyperoxaluria Type 1, Fabio Arias, Sumati Rohilla, Yudibeth Sixto-López, Koral S E Richard, Sandeep Das, Sumit K Anand, Pilar Maria Luque-Navarro, Guillermo Bañuelos-Sanchez, Juan Luis Pacheco-García, Reethika Gade, M Peyton Mckinney, Dhananjay Kumar, Jemiah Maxie, W Rylan Corr, Nilesh Pandey, Harpreet Kaur, Jibin Ding, Lin Tan, Elisha Scott, Hyung Nam, Eyal Gottlieb, A Wayne Orr, Nirav Dhanesha, Arif Yurdagul, Angel L Pey, Francisco Franco-Montalbán, José A Gómez Vidal, Oren Rom, Mónica Díaz-Gavilán Feb 2026

Targeting Oxalate Production By Combining Enzyme Inhibition And Proteolysis Activation: A Novel Therapeutic Approach For Primary Hyperoxaluria Type 1, Fabio Arias, Sumati Rohilla, Yudibeth Sixto-López, Koral S E Richard, Sandeep Das, Sumit K Anand, Pilar Maria Luque-Navarro, Guillermo Bañuelos-Sanchez, Juan Luis Pacheco-García, Reethika Gade, M Peyton Mckinney, Dhananjay Kumar, Jemiah Maxie, W Rylan Corr, Nilesh Pandey, Harpreet Kaur, Jibin Ding, Lin Tan, Elisha Scott, Hyung Nam, Eyal Gottlieb, A Wayne Orr, Nirav Dhanesha, Arif Yurdagul, Angel L Pey, Francisco Franco-Montalbán, José A Gómez Vidal, Oren Rom, Mónica Díaz-Gavilán

Faculty, Staff and Student Publications

Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder caused by hepatic oxalate overproduction due to alanine-glyoxylate aminotransferase (AGXT) deficiency. Therapeutic strategies targeting glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), key enzymes in glyoxylate metabolism, have shown promise in reducing oxalate burden. However, recently approved siRNA therapies remain limited by high cost, unfavorable pharmacokinetics, and limited global accessibility. We report the development of compound 2, a dual GO/LDHA inhibitor (K i = 390 and 40 nM, respectively) that also promotes hydrophobic tag-mediated autophagic degradation of LDHA. Its efficacy was evaluated in Agxt –/– mice, both in primary …


Editorial: Unveiling The Next Generation Of Cancer Immunity & Immunotherapy, Mohanraj Sadasivam, Nethaji Muniraj, Chellappagounder Thangavel Feb 2026

Editorial: Unveiling The Next Generation Of Cancer Immunity & Immunotherapy, Mohanraj Sadasivam, Nethaji Muniraj, Chellappagounder Thangavel

Center for Translational Medicine Faculty Papers

[This corrects the article DOI: 10.3389/fimmu.2025.1769324.].


Patient Experiences With Provision Of Telehealth Addiction Treatment Services, Kaleigh Spollen, Shane Nieves, Mph, Gregory Jaffe, Md, Msed, Vanessa Short, Phd, Mph Feb 2026

Patient Experiences With Provision Of Telehealth Addiction Treatment Services, Kaleigh Spollen, Shane Nieves, Mph, Gregory Jaffe, Md, Msed, Vanessa Short, Phd, Mph

Phase 1

Introduction: Substance use disorder (SUD) is a nationwide public health crisis, and deaths from opioids have risen significantly since 1999. In recent years, telehealth has emerged as a novel modality for SUD treatment. This study aims to evaluate patient experiences with a telehealth program for SUD, identifying barriers and facilitators to participation in the program, as well as opportunities for program improvement.

Methods: This qualitative study comprises an online survey and semi-structured interview. Individuals 18 years of age or older who have attended at least one session of Jefferson’s telemedicine program for SUD treatment were enrolled in the …


Leveraging Social Media To Disseminate Evidence-Based Messaging About Substance Use To Reduce Stigma And Promote Harm Reduction In Adolescents And Young Adults, Jacob Mihalic, Gregory Jaffe, Md, Msed Feb 2026

Leveraging Social Media To Disseminate Evidence-Based Messaging About Substance Use To Reduce Stigma And Promote Harm Reduction In Adolescents And Young Adults, Jacob Mihalic, Gregory Jaffe, Md, Msed

Phase 1

Introduction

Substance use disorder (SUD) remains a major contributor to morbidity and mortality in Philadelphia, with adolescents and young adults (AYAs) particularly vulnerable due to peer influence and digital exposure. However, harm reduction messaging rarely targets AYAs directly. This project will explore how AYAs engage with social media, how these platforms shape their perceptions of SUD, and how digital messaging can be leveraged to reduce stigma and support prevention.

Methods

This qualitative project will conduct three focus groups with Philadelphia AYAs aged 13-18, recruited through local Boys and Girls Clubs. Discussions will explore how AYAs engage with SUD-related content online, …


Staff Education To Improve Knowledge On Early Recognition Of Staff Burnout In Nurses Working In Long-Term Care, Geraldine Ndeng Akonwah Feb 2026

Staff Education To Improve Knowledge On Early Recognition Of Staff Burnout In Nurses Working In Long-Term Care, Geraldine Ndeng Akonwah

Walden Dissertations and Doctoral Studies

This doctoral project was a practice-based staff education project aimed at educating nurses concerning early burnout recognition. The educational intervention was chosen to promote awareness and knowledge related to the concept of burnout and self-care among nurses employed in a long-term care facility. The practice problem addressed was the high prevalence of nurse burnout and the limited ability of nurses to recognize early signs of burnout. The problem is significant in nursing practice as burnout is detrimental to the clinical judgment, patient safety, job satisfaction and staff retention. The guiding question of the project was as follows: Does a staff …


Emergency Nurses’ Perspectives On Workload, Stress, And Violence In The Context Of The U.S. Nursing Shortage, Wanda Marie Haynes Feb 2026

Emergency Nurses’ Perspectives On Workload, Stress, And Violence In The Context Of The U.S. Nursing Shortage, Wanda Marie Haynes

Walden Dissertations and Doctoral Studies

The nursing shortage is a critical global issue that significantly impacts emergency nurses (ER), leading to increased workloads, psychological stress, and heightened exposure to workplace violence (WPV). This phenomenon raises concerns among healthcare administrators and nurse leaders who seek strategies to improve retention and ensure quality patient care. The purpose of this qualitative study was to explore the meaning of workload, stress, and WPV among ER nurses during the U.S. nursing shortage. Guided by Herzberg’s two-factor theory, the study employed a phenomenological approach to capture nurses’ lived experiences. Data were collected through semi-structured interviews with eight ER nurses from diverse …


Community Participatory Co-Design And Development Of A Digital Diabetes Prevention Education Program For Hispanic Families With Obesity: Mixed Methods Study, Sandra Mihail, Marbelly Partida, Lizette Villanueva, Debbe Thompson, Teresia M O'Connor, Salma M Musaad, Maria J Redondo, Erica G Soltero Feb 2026

Community Participatory Co-Design And Development Of A Digital Diabetes Prevention Education Program For Hispanic Families With Obesity: Mixed Methods Study, Sandra Mihail, Marbelly Partida, Lizette Villanueva, Debbe Thompson, Teresia M O'Connor, Salma M Musaad, Maria J Redondo, Erica G Soltero

Children’s Nutrition Research Center Staff Publications

Background: Digital health interventions (DHIs) can extend the reach of disease prevention interventions; however, few are evidence-based, theoretically grounded, or developed for high-risk youth and families. Co-design approaches engage end users in the design and development of the DHI, which can lead to increased accessibility and engagement.

Objective: This study aimed to describe the adaptation of an evidence-based diabetes prevention program for remote, digital delivery.

Methods: The adaptation of the in-person intervention was guided by a modified Inclusive Digital Health Intervention Design to Promote Health Equity framework and conducted in collaboration with Hispanic adolescents (n=23) with obesity (BMI ≥95th percentile) …


How Does Pattern Of Bone Healing Affect The Strain Of Plate Implant Via Frequency Detection? A Biomechanical Cadaveric Study, Chavarin Amarase, Chanyaphan Virulsri, Pairat Tangpornprasert, Pisitpong Chancharoen, Saran Tantavisut Feb 2026

How Does Pattern Of Bone Healing Affect The Strain Of Plate Implant Via Frequency Detection? A Biomechanical Cadaveric Study, Chavarin Amarase, Chanyaphan Virulsri, Pairat Tangpornprasert, Pisitpong Chancharoen, Saran Tantavisut

Chulalongkorn Medical Journal

Background: Detecting bone union is a crucial process in treating bone fractures to prevent complications, including implant failure and bone nonunion. Nowadays, there are many methods and new innovative devices for detecting bone union through strain measurements, such as strain gauges, fluid level displacement, contrast media, and frequency changes. There is also a trend toward increasing these methods in the future. However, the patterns of bone healing studied with these methods still do not provide a standard for determining the true bone healing process. The aim of this study is to identify the most appropriate bone healing pattern for …


The Effect Of Social Media On Orthodontics: The Patient And Practitioner Perspective, Corban Ward, Jacob Marx, Man Hung, Samuel Dyal, Alicia Parry Feb 2026

The Effect Of Social Media On Orthodontics: The Patient And Practitioner Perspective, Corban Ward, Jacob Marx, Man Hung, Samuel Dyal, Alicia Parry

Annual Research Symposium

Introduction Social media now shapes how people find information, connect and form identity. It increasingly influences cultural standards around  health and appearance. In orthodontics, these platforms are reshaping public perceptions, attitudes and treatment decisions. This review synthesizes existing research on social media’s impact on how people view and choose orthodontic care.

Methods A PRISMA guided review searched PubMed, Scopus, and Web of Science for  peer-reviewed English-language studies published between 2015 and 2025. Using terms such as “social media,” “orthodontic treatment,” “dental esthetics,” “perception,” we included studies assessing how social media shapes public beliefs, behaviors, and  self-perception related to orthodontic care. …


Adolescent Drug Use Prevention Programs Published 2013-2023: A Systematic Review Of Literature Reviews And Meta-Analyses, Marilyn A. Rhames, Jon Eckert, William L. Sterrett, Grant Morgan Feb 2026

Adolescent Drug Use Prevention Programs Published 2013-2023: A Systematic Review Of Literature Reviews And Meta-Analyses, Marilyn A. Rhames, Jon Eckert, William L. Sterrett, Grant Morgan

Journal of Organizational & Educational Leadership

Background: This systematic review of reviews and meta-analyses provides education leaders with ten years of evidence-based strategies for effective adolescent substance use prevention. Methods: Following the PRISMA 2020 protocol for systematic reviews, we searched the PubMed and PsychINFO databases on October 19, 2023, and identified 96 systematic literature reviews and meta-analyses involving adolescent drug use prevention from 2103-2023. Twenty-four papers met the criteria for final inclusion. Results: Educational leaders should know three areas to deliver effective evidence-based adolescent substance prevention: 1) foundational understanding of risk and protective factors, 2) components of effective prevention programs, and 3) drug-specific …


Emerging Trends And Challenges In International Student Research: A Content Analysis Of Recent Dissertations (2022–2024), Krishna Bista, Oluwasegun Adesola Oladipo, Lin Ge, Tian Qin Feb 2026

Emerging Trends And Challenges In International Student Research: A Content Analysis Of Recent Dissertations (2022–2024), Krishna Bista, Oluwasegun Adesola Oladipo, Lin Ge, Tian Qin

Health Care Administration Faculty Research

This study presents a content analysis of 470 doctoral dissertations published between 2022 and 2024, examining emerging trends, theoretical frameworks, and research approaches related to international students. Using a qualitative content analysis approach and descriptive statistics, the study systematically analyzed the dissertations to identify recurring themes and issues. The key themes identified include teaching and learning; academic practices; acculturation and intercultural competence; career development and leadership; experiences and challenges; mobility and policy contexts; social diversity and inclusion; institutional support; and well-being. The findings show a predominant use of qualitative methods, a concentration on U.S.-based contexts, and a strong disciplinary focus …


Experiences Of Care-Seeking Parents With Children With Autism Spectrum Disorder In India, Yash Navnit Patel Feb 2026

Experiences Of Care-Seeking Parents With Children With Autism Spectrum Disorder In India, Yash Navnit Patel

Walden Dissertations and Doctoral Studies

Autism spectrum disorder (ASD) affects approximately 18 million individuals in India, yet the factors influencing parental care-seeking behavior were not well understood. Guided by the health belief model, the purpose of this basic qualitative study was to explore how parents’ perceived severity of a child’s symptoms, parental beliefs about the causes of autism, and perceived mental and physical health outcomes of caregiving influence parents’ intention to seek services for children aged 1–10 years diagnosed with ASD in India. Data were collected using semistructured interviews with 10 mothers of autistic children. Data were analyzed using Braun and Clarke’s six-step thematic analysis. …


Associations Between Overt And Subclinical Hypothyroidism In Pregnancy And Adverse Maternal And Neonatal Outcomes: A Cohort Study, Rahma Al Kindi, Noof Al Ghammari, Amina Al Malki, Aida Al Ismaili, Hana Al Sumri Feb 2026

Associations Between Overt And Subclinical Hypothyroidism In Pregnancy And Adverse Maternal And Neonatal Outcomes: A Cohort Study, Rahma Al Kindi, Noof Al Ghammari, Amina Al Malki, Aida Al Ismaili, Hana Al Sumri

Sultan Qaboos University Medical Journal

Objectives: This study aimed to determine associations between hypothyroidism during pregnancy and selected maternal and neonatal outcomes. Methods: A retrospective, cohort study was conducted between January 2018 and December 2020 at the two main tertiary hospitals in Muscat, Oman. The study included 408 Omani pregnant women aged 18–45 years. Participants were divided into two groups: those diagnosed with overt or subclinical hypothyroidism (n = 201; exposed group) and those with normal thyroid function (n = 207; unexposed group), matched for relevant variables. Data were collected from electronic medical records to assess maternal and neonatal outcomes. Results: Most exposed women …


Potential Mediators In The Relationship Between Racial Identity And Neuropsychological Performance In A Retired Nfl Cohort, Claire Stafford, Charles Golden, Ryan Bennett Feb 2026

Potential Mediators In The Relationship Between Racial Identity And Neuropsychological Performance In A Retired Nfl Cohort, Claire Stafford, Charles Golden, Ryan Bennett

Archives of Assessment Psychology

Historically, Black Americans have consistently performed more poorly than White Americans on various neuropsychological tests, with debates surrounding the causes of these differences ranging from genetic to societal factors. These differences have been documented across various cognitive domains, including memory, attention, executive function, and processing speed. Findings from previous research suggest that individuals with higher levels of education and stable marital relationships tend to exhibit better cognitive functioning, while certain football positions are linked to differences in cognitive abilities. However, the specific effects of these factors on neuropsychological performance require further investigation. The present archival study was derived from a …


Ex Vivo Microfluidic Model Identifies A Role For Shear Stress During Ovarian Tumor Cell Attachment To Peritoneal Mesothelial Cells, Vasilios A Morikis, Breanna Baker, Jillian A Martin, Angela Schab, Alessandra Dimauro, Gregory D Longmore, Whitney R Grither Feb 2026

Ex Vivo Microfluidic Model Identifies A Role For Shear Stress During Ovarian Tumor Cell Attachment To Peritoneal Mesothelial Cells, Vasilios A Morikis, Breanna Baker, Jillian A Martin, Angela Schab, Alessandra Dimauro, Gregory D Longmore, Whitney R Grither

2020-Current year OA Pubs

Ascites, or a pathologic accumulation of intra-abdominal fluid, is a key feature of intraperitoneally disseminating cancers, such as ovarian cancer. This pathological fluid buildup can influence the adhesive abilities of ovarian cancer cells, as they spread throughout the abdominal cavity to form metastatic implants on organs lined with a specialized monolayer of mesothelial cells. Robust methods for assessing the impact of fluid shear stress on this cell-cell interaction are lacking. Here, we develop and characterize a novel microfluidic device that allows for the determination of the attachment of ovarian tumor cells to mesothelial cells under the influence of fluid flow. …


Ex Vivo Microfluidic Model Identifies A Role For Shear Stress During Ovarian Tumor Cell Attachment To Peritoneal Mesothelial Cells, Vasilios A Morikis, Breanna Baker, Jillian A Martin, Angela Schab, Alessandra Dimauro, Gregory D Longmore, Whitney R Grither Feb 2026

Ex Vivo Microfluidic Model Identifies A Role For Shear Stress During Ovarian Tumor Cell Attachment To Peritoneal Mesothelial Cells, Vasilios A Morikis, Breanna Baker, Jillian A Martin, Angela Schab, Alessandra Dimauro, Gregory D Longmore, Whitney R Grither

2020-Current year OA Pubs

Ascites, or a pathologic accumulation of intra-abdominal fluid, is a key feature of intraperitoneally disseminating cancers, such as ovarian cancer. This pathological fluid buildup can influence the adhesive abilities of ovarian cancer cells, as they spread throughout the abdominal cavity to form metastatic implants on organs lined with a specialized monolayer of mesothelial cells. Robust methods for assessing the impact of fluid shear stress on this cell-cell interaction are lacking. Here, we develop and characterize a novel microfluidic device that allows for the determination of the attachment of ovarian tumor cells to mesothelial cells under the influence of fluid flow. …


Myokine Sirpα Exacerbates Kidney Disease In Diabetes, Jiao Wu, Elisa Russo, Daniela Verzola, Qingtian Li, Helena Zhang, Bhuvaneswari Krishnan, David Sheikh-Hamad, Zhaoyong Hu, William E Mitch, Sandhya S Thomas Feb 2026

Myokine Sirpα Exacerbates Kidney Disease In Diabetes, Jiao Wu, Elisa Russo, Daniela Verzola, Qingtian Li, Helena Zhang, Bhuvaneswari Krishnan, David Sheikh-Hamad, Zhaoyong Hu, William E Mitch, Sandhya S Thomas

Faculty, Staff and Students Publications

Mechanisms responsible for skeletal muscle kidney crosstalk have not been defined. We have determined that a circulating mediator, signal regulatory protein α (SIRPα), impairs intracellular insulin-mediated functions. To elucidate the effect of myokine SIRPα on diabetic kidney disease (DKD), flox mice and muscle-specific (m-specific) SIRPα-KO mice were subjected to an obesity-induced model of diabetes, high-fat diet (HFD; 60%) or insulin-deficient hyperglycemia model, streptozotocin (STZ), and were subsequently exposed to anti-SIRPα monoclonal antibodies. In the obesity-induced diabetic mice, serum SIRPα increased. Genetic deletion of muscle SIRPα protected against obesity and improved intracellular insulin signaling in muscle and adipose tissue, with reduced …


Intouch Week Of February 9, 2026, New York Medical College Feb 2026

Discovery And Characterization Of A Novel Pseudomonas Phage Of A New Genus, Paul Nicholls, Justin R Clark, Anthony Maresso Feb 2026

Discovery And Characterization Of A Novel Pseudomonas Phage Of A New Genus, Paul Nicholls, Justin R Clark, Anthony Maresso

Faculty, Staff and Students Publications

Background: Bacteriophages exhibit great diversity and are classically divided into lytic and temperate lifestyles. Commonly, bioinformatics is used to predict the temperate lifestyle. As the nosocomial pathogen Pseudomonas aeruginosa is common in freshwater, this biome represents an ideal location for the discovery of Pseudomonas phages.

Materials and methods: We characterized a genetically distinct species of Pseudomonas phage using next-generation sequencing and conventional microbiological methods. We characterized its lifestyle by purifying infected colonies and identifying persistent phage production.

Results: Genetics revealed a phage of a novel genus. Characterization showed a narrow host range and bioinformatics suggested a lytic lifestyle. Experimental data …


Paying The Price For Beauty Abroad: Khoula Hospital’S Experience With Complications Following Aesthetic Procedures Performed Overseas, 2013–2023, Khalifa Al Alawi, Areej Al-Mamari, Maysa Al-Maawali, Ashima Alkabi, Al-Batul Al-Mufargi, Juhaina Al Tobi, Hoor Al-Khanjari, Yasmine Al Balushi, Rawan Al Mandhari, Rafal Aljadder, Sultan Al Shaqsi Feb 2026

Paying The Price For Beauty Abroad: Khoula Hospital’S Experience With Complications Following Aesthetic Procedures Performed Overseas, 2013–2023, Khalifa Al Alawi, Areej Al-Mamari, Maysa Al-Maawali, Ashima Alkabi, Al-Batul Al-Mufargi, Juhaina Al Tobi, Hoor Al-Khanjari, Yasmine Al Balushi, Rawan Al Mandhari, Rafal Aljadder, Sultan Al Shaqsi

Sultan Qaboos University Medical Journal

Objective: This study aimed to evaluate the types and outcomes of complications arising from aesthetic surgeries performed abroad and subsequently managed at Khoula Hospital, Muscat, Oman. Methods: This retrospective study included patients who presented with post-aesthetic surgical complications after undergoing procedures outside Oman from January 2013 to December 2023. Data were extracted from Khoula Hospital’s electronic health records, focusing on demographics, procedures performed, types of complications and outcomes, including admissions and surgical interventions. Results: A total of 191 patients with 488 recorded encounters were included. The most common procedures done overseas were abdominoplasty (50.8%), lipectomy (29.3%) and …


Leveraging The Translational Science Benefits Model To Plan And Measure Early Impact In The Heart Failure Polypill Implementation Trial In Sri Lanka, Adam Hively, Anna La Manna, Ella Clark, Douglas Luke, Asita De Silva, Mansi Agarwal, Mark D Huffman, Abdul Salam, Anubha Agarwal, Emmanuel K Tetteh Feb 2026

Leveraging The Translational Science Benefits Model To Plan And Measure Early Impact In The Heart Failure Polypill Implementation Trial In Sri Lanka, Adam Hively, Anna La Manna, Ella Clark, Douglas Luke, Asita De Silva, Mansi Agarwal, Mark D Huffman, Abdul Salam, Anubha Agarwal, Emmanuel K Tetteh

2020-Current year OA Pubs

No abstract provided.