Digital Commons Network^™

From Arrival To Opportunity: A Policy Analysis For Supporting Newly Arrived English Learners In California, Valeria Gabrielli, Stephanie Mendoza Hernandez

School of Public Policy Capstones

Newly arrived immigrant students, commonly referred to as “newcomers,” represent a notable portion of the English Learner (EL) population in California’s K–12 public schools. As of Fall 2023, the California Department of Education reported that newcomers comprised 3.27% of total student enrollment. Although enrollment is projected to decline in the near term, the potential for future increases highlights the need for sustainable, evidence-based support systems. This study examines how California K–12 public schools with large EL populations provide academic and trauma-informed support services to newcomer students, with a particular focus on early intervention in grades K–5. Using the Bardach policy …

Nano Zinc Oxide Against Bacteria Isolated From Burn Infection, Mohammed Jaafar Al-Anssari, Mohammed Sahib Al-Hamami, Hayder Razzaq Al-Ameedee, Rabab Abdul Razzaq Kasema, Hawraa Majid Mahdi

Al-Bahir

Pseudomonas aeruginosa is a type of bacteria that is found commonly in the environment, like in soil and in water. This bacteria can cause infections in the blood, lungs (pneumonia), or other parts of the body after surgery. These bacteria are constantly finding new ways to avoid the effects of the antibiotics used to treat the infections they cause. Zinc oxide nanoparticles' (ZnO-NPs') or Nano zinc oxide antibacterial properties have drawn a lot of attention from around the world, especially since nanotechnology has been used to create particles in the nanometer range. Because of their larger specific surface area and …

Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese Ph.D., Jiajia Zhang Ph.D., Elizabeth Angela Murphy, Susan E. Steck Phd, Mph, Rd

Faculty Publications

Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …

Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese, Jiajia Zhang, Elizabeth Angela Murphy, Susan E. Steck

Faculty Publications

Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …

Collaborative Care For Depression In Chronic Illness: A Narrative Review, Chun Wong, German E. Corso

School of Medicine Publications

Background: Depression commonly coexists with chronic medical illness and is associated with impaired self-management, poor adherence, increased healthcare utilization, and higher mortality.

Objective: To synthesize evidence published between 2000 and late 2025 on the effectiveness of the Collaborative Care Model (CoCM) for depression in adults with chronic medical illness, with particular attention to contemporary U.S. implementation, policy, and equity considerations.

Methods: A narrative review of randomized controlled trials, pragmatic and implementation studies, systematic reviews, and policy analyses was conducted using PubMed, PsycINFO, and Scopus. Evidence addressing collaborative care for depression in adults with chronic medical illness was identified and synthesized …

Effective Spectrum-Based Antibiotic Resistance Index For Monitoring Resistance In Gram-Negative Bacilli, M Cristina Vazquez Guillamet, Alice Bewley, Nicole J Tarlton, Reid Goodman, Michael J Durkin, Michael Bernauer, Meghan Brett, Kevin Hsueh, Cristian Bologa, George Turabelidze, Andrew Atkinson, Victoria J Fraser

2020-Current year OA Pubs

BACKGROUND: Antimicrobial resistance (AMR) is a growing public health threat, and we currently lack accurate measures to track and trend this resistance. We developed the antibiotic resistance index (ARI) that aggregates resistance of Gram-negative bacilli (GNB) into a single metric which can be tracked across healthcare settings and over time.

METHODS: Culture data were collected from adult patients who met the CDC adult sepsis event criteria across 10 Barnes-Jewish HealthCare (BJC) hospitals between January 2018 and December 2023. An antibiotic's effective spectrum (AES) was calculated as the ratio of susceptible GNB to all identified GNB. The ARI was calculated as …

Identifying Risk Factors For The Rising Prevalence Of Multiple Sclerosis In Saudi Arabia: A Case-Control Analysis, Omar Babateen, Jamil Adnan Samkari, Rewaa Abdulaziz Alkaki, Sadin Ayman Alamri, Manal Mutlaq Alzahrani, Mussaed Saleh Alharbi, Ali Abdulrazaq Alghamdi, Amwaj Sultan Aljurays, Amjad Faleh Aldosari, Seraj Makkawi

Neurosciences

Objective: This study aims to identify risk factors linked to the increasing prevalence of multiple sclerosis (MS) in Saudi Arabia. Multiple sclerosis is a chronic autoimmune condition affecting the central nervous system, marked by inflammation and damage to nerves and the myelin sheath.

Method: A case-control study conducted from September 2022 to January 2024 included 832 participants—263 diagnosed with MS and 569 controls. Controls were matched by age, gender, residence, and employment status. Data was collected using a validated questionnaire, with written consent obtained from participants aged 18 and older. Logistic regression analysis was used to ascertain risk factors.

Results: …

Key Attributes Of An Ideal Neurology Residency Candidate: Program Directors’ Perspectives, Bandar N. Aljafen, Ruwa A. Alneseyan, Rahmah M. Alsawad, Mohamed Bahr

Neurosciences

Objectives: To guide medical students and interns interested in neurology by identifying the key attributes of an ideal neurology candidate from the perspectives of neurology program directors (PDs).

Methods: In this cross-sectional study, former and current neurology PDs were contacted across Saudi Arabia to complete a self-administered survey sent via email or text. The survey included seven questions: six on PD demographics and a seventh with 51 items evaluating candidate attributes on a 7-point Likert scale from disadvantage to advantage.

Results: Thirty-two neurology PDs filled out the questionnaire. Among the key attributes PDs prioritized in a candidate is their letter …

Functional And Structural Basis Of A Hypermorphic Trpc3 Variant, Briar Bell, Angela M Jaramillo-Granada, Luis O Romero, Irene A Gutierrez, Venkata K P S Mallampalli, Guizhen Fan, Sameer Varma, Matthew L Baker, Irina I Serysheva, Valeria Vásquez, Julio F Cordero-Morales

Faculty, Staff and Student Publications

Cerebellar ataxias are characterized by impaired motor coordination resulting from neuronal dysfunction within the cerebellum. The mechanisms underlying this pathology and its cerebellar-specific neurodegeneration remain unknown. We uncover how a gain-of-function canonical transient receptor potential member 3 (TRPC3) mutation, coupled with a cerebellum-specific isoform, stabilizes the channel’s open state, resists the leading inhibitor Pyr3, and drives calcium-dependent cell death. Restoring calcium homeostasis by expressing a Purkinje cell calcium pump improves cell viability. Transgenic expression of the TRPC3 hypermorphic variant in Caenorhabditis elegans induces neurodegeneration, confirming its pathogenicity across species. Cryo–electron microscopy and molecular simulations reveal the structural basis for the …

Shared Decision-Making For Patient Compliance, Lydia Vernon, Breanna Day

Scholars Week

This evidence-based project focuses on shared decision-making between the healthcare team and the patient. As well as how this implementation affects patient compliance. An issue of patient noncompliance was brought to attention, and this project will address how shared decision-making interventions can decrease patients’ feelings of overwhelmingness and underpreparedness, ultimately leading to better compliance after discharge. By focusing on these interventions, patient compliance increases, and as a result, patient outcomes benefit, and readmission rates decline.

Socioeconomic Disparities In Readmission Outcomes And Cardiac Procedures Among Atrial Fibrillation Hospitalizations, Muhammad U. Almani, Muhammad Yousuf, Noor Fatima, Muhammad Q. Ullah, Muhammed Arshad

Einstein Health Papers

Introduction: Atrial fibrillation (AF) remains one of the leading dysrhythmias incurring hospitalization. We set out to determine the impact of socioeconomic status (SES) on in-hospital cardiac procedures and the readmission outcomes in patients with AF. Methods: The National Readmission Database (NRD) was searched for adults with a primary diagnosis of AF between 2010 and 2019. We determined unplanned AF-specific readmission within 30 days. Median neighborhood household income was assessed by patient zip code as quartiles: low income (Q1), middle income (Q2), upper-middle income (Q3), and high income (Q4). Differences in in-hospital cardiac procedures during the index hospitalization and probability of …

Fierce Leadership-Perspectives Of Black Women Educational Leaders: A Transcendental Phenomenological Study, Janice Taylor, Dianne Reed

Tapestry: Journal of Research in Education

The authors of this transcendental phenomenological study aimed to describe the lived experiences of Black women based on their perceptions, values, and beliefs about the complexities of leadership and the kind of leadership required to succeed in their respective roles, as educational leaders. This study was framed by the adaptive leadership theory. Adaptive leadership recognizes the need for leaders to stay flexible and resilient in fast-paced environments (Nelson & Squires, 2017). The three Black women leaders in this study were fierce adaptive leaders. The information acquired from this study is significant and highlights how Black women educational leaders developed the …

Recent Progress In Nanogel Technology: From Molecular Design To Biomedical Applications, Fatima Raed Al-Ahmed, Mohammed Sabar Al-Lami

Maaen Journal for Medical Sciences

Nanogels, a hydrophilic polymer network at the nanoscale, combine the structural flexibility of hydrogels with the dynamic behavior of nanoparticles, offering unprecedented control over drug loading and release. Their large surface area, tunable porosity, high water content, biocompatibility, and stimuli-responsive behavior enable transport across biological barriers. This review critically examines nanogels’ unique properties, classifications, diverse methods of preparation, drug release mechanisms, characterization techniques, and various applications in therapeutic areas, such as cancer therapy, wound healing, transdermal and ocular drug delivery, and theranostics. Highlights are shed on nanogels’ potential to target specific sites, both by functionalization and stimuli-responsive behavior, therefore improving …

Evaluation Of Nurses' Leadership Self-Efficacy In Belize, Ruth Rosalee Reina Jones

Walden Dissertations and Doctoral Studies

Nursing leadership in Belize is lacking but crucial to the well-being of patients, families, and the healthcare team. The purpose of this non-experimental, descriptive, comparative study was to a) determine the difference in leadership self-efficacy for current nurse leaders with three years or less of leadership experience compared to current nurse leaders with more than three years of leadership experience in Belize, and b) examine the differences in leadership self-efficacy between nurses in a leadership position and nurses not in a leadership position in Belize. The theories supporting the study were Burns’ transformational leadership theory and leadership self-efficacy, based on …

Mitochondria-Mediated Apoptotic Induction By Chionanthus Virginica Q: A Cytotoxic And Oxidative Stress-Driven Approach In Hepg2 Hepatocellular Carcinoma Cells, Arun R. Nair, Venkateshan Hariram, Vettrivel Arul

Indian Journal of Research in Homoeopathy

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, with current therapeutic options limited by late-stage detection, recurrence, and toxicity. Alternative treatments derived from medicinal plants are gaining attention due to their potential anticancer properties. Chionanthus virginica, traditionally used for liver disorders, contains bioactive compounds with hepatoprotective and antioxidant effects. However, its anticancer potential remains largely unexplored. Objective: This study evaluates the antioxidant, cytotoxic, and apoptotic effects of Chionanthus virginica in mother tincture (Q) and potentised (12C) forms on HepG2 liver cancer cells to determine its efficacy as a natural anticancer agent. Materials and methods: HepG2 …

Homoeopathy During One Hundred Years Of Lmhi (1925–2025) – Part 2: Historical Perspectives* (Continued From Part 1, Published In The Last Issue)1, Josef M. Schmidt

Indian Journal of Research in Homoeopathy

Taking Hahnemann in his entirety, as a paradigmatic example of a true homoeopath, as a sound basis for a proper understanding of Homoeopathy, the ``scientific-critical'' school of homoeopaths seems to miss one constitutive part of Homoeopathy: its spiritual embedment into a greater frame of thinking and feeling. In fact, the greatest successes of Homoeopathy, in terms of popularisation, institutionalisation and implementation into social and cultural practice, were achieved in countries and periods open towards spiritual dimensions. This was the case in North America at the end of the 19^th century, when James Tyler Kent propagated a Hahnemannian Homoeopathy inspired …

Spatial Narrative Beyond The Proscenium: Set Design As A Tool For Wellness, Christina Griffey

LSU Master's Theses

Inspired by a health crisis that led to spending time in medical settings, this thesis examines how our surroundings impact our well-being. By developing a framework that explores the topics of storytelling, space, place, theatre, and expanded scenography, I propose that set design can be used as a tool for wellness. I explore several disciplines through the lens of set design and highlight the disciplines, professionals, and designers that are contributing to the creation of therapeutic environments using scenographic practices.

Indian Standard For Alfalfa (Medicago Sativa L.), Kumar Vivekanand, Daisy Katarmal, Indra Gaurav Saxena, Binit Dwivedi, Divya Taneja, Shrishti Dixit, Raj Kumar Manchanda

Indian Journal of Research in Homoeopathy

Traditional systems of medicine remain integral to global healthcare, yet variability in herbal raw materials has long challenged their scientific validation and regulatory acceptance. Differences in environmental conditions, harvesting, processing and formulation techniques significantly influence the herb's phytochemical composition, potency, and therapeutic outcomes. Standardisation is therefore essential to ensure safety, efficacy, reproducibility, and regulatory credibility. In this context, the Bureau of Indian Standards (BIS) has developed Indian Standards for medicinal plants and homoeopathic preparations. This article presents an overview of IS 18978:2024, Alfalfa (Medicago sativa L.) for Use in Traditional Medicine—Specification, and IS 19135:2025, Alfalfa Hydro-alcoholic Extract for Use …

Fasting-Based Dietary Interventions In Cancer Patients And Survivors: A Scoping Review, Kuang-Yi Wen, Julianne Freedman, Abenezer Melaku Tafese, William Kevin Kelly, Nicole L Simone

Department of Medical Oncology Faculty Papers

Background: Fasting-based interventions are increasingly investigated as adjuncts to cancer treatment for the potential to reduce therapy-related toxicities, improve metabolic health, and enhance quality of life. However, clinical evidence regarding their efficacy, tolerability, and acceptability remains limited and fragmented. This scoping review aimed to systematically map the current evidence on fasting-based interventions in cancer patients and survivors.

Methods: A literature search was conducted in PubMed, Scopus, Web of Science, and CINAHL up to 10 June 2025. Eligible interventional studies included cancer patients or survivors and evaluated fasting-based interventions, such as time-restricted eating, intermittent fasting, short-term fasting, or fasting-mimicking …

Engagement Patterns With #Naturalremedies On Tiktok: Formative Analysis, Apeksha Mewani, Corey H. Basch, Keanu Renne-Glover, Vincent Jones Ii, Cristiana Cordero, Adea Gutiqi

Publications and Research

This research letter provides formative evidence from a cross-sectional analysis of 118 TikTok videos under #NaturalRemedies, identifying content formats and expertise cues associated with higher engagement, while also demonstrating the feasibility of using engagement metrics and thematic coding to analyze health narratives on emerging platforms such as TikTok.

Parents Engaging In Early Literacy (Peel): Outcomes From A Shared Reading Program Implemented Via Text Messaging, Victoria Henbest, Brenda L. Beverly, Gina M. Mejia

Victoria S. Henbest Publications

Purpose: Investigators delivered an asynchronous parent education for improving early literacy skills of typically developing preschoolers. The home-based shared-book reading program, PEEL, consisted of strategies modeled via videos and sent as text messages.

Method: Twenty parent-child dyads were randomly assigned to one of two 8-week programs targeting evidence-based early literacy strategies. One parent group was taught strategies to support print-related knowledge for learning to read, and the other learned skills to promote vocabulary and story knowledge underlying comprehension.

Results: The asynchronous parent education resulted in more frequent parental use of taught strategies compared to non-taught strategies during …

Randomized Controlled Trial Outcomes For Homestyles-2, An Online Obesity Prevention Program For Families With Children In Middle Childhood, Carol Byrd-Bredbenner, Angelica A. Pozzoli, Kaitlyn M. Eck, John Worobey, Karla Pagan Shelnutt, Melissa D. Olfert, Virginia Quick

College of Health Professions Faculty Papers

Background: Parents are children’s primary role models, are food and physical activity gatekeepers, and create the home structure/lifestyle environment. Thus, parents strongly influence children’s weight-related behaviors and have the opportunity to cultivate a “culture of health” within the home. Methods: The aim of the HomeStyles-2 (also called HomeStyles-Child) RCT was to determine whether this online, novel, age-appropriate, family intervention enabled and motivated the 131 systematically randomly assigned by computer parents of children in middle childhood (ages 6 to 11) in the experimental condition to shape home environments and healthy weight-related lifestyle practices to be more supportive of optimal health and …

“For Us, Drones Mean Health”: How Medical Drone Delivery Affects Healthcare Outcomes, Accessibility, And Trust In Remote Regions Of Madagascar, Brianne O'Sullivan, Christallin Lydovick Rakotoasy, Lorie Donelle Phd, Rn, Fcan, Nicole Haggerty, Elysée Nouvet

Faculty Publications

Medical drone delivery (MDD), defined as the use of uncrewed aerial vehicles to transport medical products, is an emerging technological innovation responding to persistent health supply chain challenges in rural and low-resource settings. Within sub-Saharan Africa, MDD systems have demonstrated large-scale success in improving key health outcomes, health supply chain efficiency, and reductions in medical product stockouts and wastage. However, the existing evidence base on the effectiveness of this technology is dominated by quantitative, performance-based evaluations, with limited emphasis on the community-driven mechanisms that shape such outcomes. Drawing on original qualitative research, this article presents a qualitative secondary analysis (QSA) …

Tulane Virus Protease As A Structural Surrogate For Inhibitor Screening Of Human Norovirus Proteases, Son Pham, Nikhil Sharma, Banumathi Sankaran, Jalen Nguyen, Mary K Estes, Joseph M Hyser, B V Venkataram Prasad

Faculty, Staff and Students Publications

Human norovirus (HuNoV) is a significant cause of gastroenteritis worldwide, affecting people of all age groups. There are currently no vaccines or drugs available, leaving susceptible populations vulnerable to severe or protracted illness. A HuNoV cultivation system is pivotal for screening norovirus antivirals. While the human intestinal enteroid cultivation system allows robust replication of multiple HuNoV strains, it presents technical and cost barriers. Tulane virus (TV), a surrogate for HuNoV, replicates well in monkey kidney cell lines and is closely related to norovirus in cellular biology. Here, we determined the structures of TV protease (TV-Pro) alone and in complex with …

A Cross-Sectional Survey On Hpv Vaccination In A Houston Hiv Clinic, Shailee R Modi, Erika S Fanous, Avery N Sinnathamby, Laura O Van Buskirk, Jason L Holliday, J Brooks Jackson, Mary B Rysavy

Faculty, Staff and Student Publications

Background/Objectives: Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and causes cervical cancer in women. Patients with human immunodeficiency virus (HIV) are particularly susceptible to this virus. An effective vaccine against high-risk HPV genotypes is available. This study sought to evaluate barriers to HPV vaccination in HIV-positive female patients between the ages of 18 and 65 in a county clinic in Houston.

Methods: A cross-sectional survey was conducted in May-June 2025 with 131 patients at Thomas Street Health Center in Houston. The survey assessed patient demographics, attitudes toward and knowledge of HPV vaccination (at least one dose), …

Contrast-Associated Acute Kidney Injury After Thrombectomy For Ischemic Stroke: Prognostic Impact And Can-Rest Predictive Score, Ghil Schwarz, Angelo Cascio Rizzo, Gareth Ambler, Pawel Wrona, Agnieszka Slowik, Szymonn Kotas, Mohamed F. Doheim, Alhamza R. Al-Bayati, Raul G. Nogueira, Ameer E. Hassan, Samantha Miller

School of Medicine Publications

Background and objectives: Contrast-associated acute kidney injury (CA-AKI) is a potentially preventable complication after exposure to iodinated contrast media. In patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke (AIS), the incidence and clinical impact are poorly characterized, and no validated prediction tool is currently available. The aim of this study was to assess the incidence and prognostic significance of CA-AKI in EVT-treated patients with AIS and to develop and validate a predictive score.

Methods: A retrospective, multicenter cohort study was conducted involving EVT-treated patients across 73 centers in 16 countries (January-December 2023). Inclusion criteria were age ≥18 years, absence …

A Mitochondrial Plasma Proteomic Signature Identifies Metastatic Chromophobe Renal Cell Carcinoma, Clara Steiner, Tiegang Han, Steven Safi, Wafaa Bzeih, Hadi Mansour, Eddy Saad, Jessica F. Williams, Vinay K. Giri, Liliana Ascione, Yehonatan Elon, Adam P. Dicker, Yan Tang, Toni K. Choueiri, Elizabeth P. Henske, Wenxin Xu

Department of Radiation Oncology Faculty Papers

BACKGROUND: Chromophobe renal cell carcinoma (ChRCC) is characterized by the accumulation of abnormal mitochondria, a high rate of mitochondrial DNA (mtDNA) mutations, and altered oxidative metabolism. There are no existing circulating biomarkers to distinguish metastatic ChRCC from clear cell renal cell carcinoma (ccRCC).

METHODS: High-throughput plasma proteomic profiling using the SomaScan platform was performed in 18 ChRCC (including 16 metastatic ChRCC) and 197 metastatic ccRCC patients. Data were harmonized to generate a unified 7K-protein matrix.

RESULTS: Differential expression analysis was performed using limma (version 3.62.2). Of 7272 quantified human plasma proteins, 209 were differentially expressed between ChRCC and ccRCC. Upregulated …

Whole-Genome Crispr Screening Identifies Genetic Modifiers Of Stem Cell-Derived Islet Transplantation, Marlie M Maestas, Kameron Bradley, Mira Shunkarova, Noyonika Mukherjee, Matthew Ishahak, James Lu, Jeffrey R Millman

2020-Current year OA Pubs

INTRODUCTION: Genetically engineering human pluripotent stem cell (hPSC)-derived islets is a promising strategy for improving transplantation for diabetes cell therapy; however, genetic perturbations that modulate transplantation outcomes have yet to be systematically explored.

METHODS: To identify potential targets, we performed an unbiased whole-genome CRISPR-activation screen in transplanted stem cell-derived islets (SC-islets). Specifically, we created a stem cell line with CRISPR-activation components (HUES8-VPR) and then transduced these stem cells with a lentiviral guide RNA library targeting the whole human genome. Following transduction, the stem cells were differentiated into SC-islets, which were subsequently transplanted into NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) immunodeficient mice. After transplantation, SC-islets …

Contribution Of G4 Structure To Alzheimer’S Disease And Tau Pathology, Lena Michaela Kallweit

Electronic Theses and Dissertations

The occurrence of Alzheimer’s Disease (AD) is rapidly increasing as our global population ages. With the majority of therapeutic drugs in the last couple of decades failing clinical trials, new molecular targets are needed to combat the expected influx of new AD cases. AD pathogenesis is associated with abnormal protein aggregation, characterized in part by intracellular accumulation of hyperphosphorylated tau (p-tau) in neurofibrillary tangles (NFTs). RNA has been identified as a major non-proteinaceous component of NFTs and has been implicated as an active cofactor in tau aggregation and spread. Recent work has shown that aggregates from AD brains contain almost …

Chatgpt Versus Uptodate In Preclinical Medical Education: Cross-Sectional Analysis Using Term Frequency-Inverse Document Frequency Cosine Similarity, Shankar S. Thiru, Nicholas E. Aksu, Matthew Chiang, Daniel O. Gallagher, Mary Furlong, Elizabeth R. Prevou, Akhil Jay Khanna

Rothman Institute Papers

BACKGROUND: Generative artificial intelligence tools such as ChatGPT are increasingly used by medical students for self-directed learning. Although these models demonstrate linguistic fluency, their reliability as supplementary resources for preclinical education remains uncertain. In particular, comparisons with evidence-based references such as UpToDate are lacking.

OBJECTIVE: This study evaluated the similarity between responses generated by ChatGPT (with GPT-4o mini) and those from UpToDate to preclinical medical education questions to assess ChatGPT's potential as an adjunctive learning tool.

METHODS: We conducted a cross-sectional comparison study using 150 first-order questions derived from a preclinical question bank at a single allopathic institution under the …