Digital Commons Network^™

Career Adaptability Of Prospective Teachers With Disabilities In Indonesia: A Phenomenological Study, Rr Dwi Umi Badriyah, Erfan Ramadhani, Ramtia Darma Putri, Syska Purnama Sari, Amândio De Araújo Sarmento, Kadek Suhardita

Jurnal Kajian Bimbingan dan Konseling

Pre-service teachers with disabilities face career transitions shaped by personal aspirations, accessibility barriers, stigma, and limited role models. In Indonesia, little is known about how they build career readiness for teaching within inclusive unequal educational contexts. This study explores the career adaptability of pre-service teachers with disabilities in Indonesia. Grounded in Career Construction Theory, it examines concern, control, curiosity, and confidence, while extending the framework by considering resilience and flexibility as relevant dimensions. A qualitative phenomenological design was used. Twenty-five students with disabilities enrolled in Primary School Teacher Education and Special Education programs at an Indonesian university participated in semi-structured …

A Multidomain Peptide Hydrogel-Liposome Composite For Controlled Release Of A Cyclic Dinucleotide In Oral Cancer, Joseph W R Swain, Andrea H Molina, Gemalene M Sunga, Danielle Chew-Martinez, Neeraja Dharmaraj, Alejandra Cobos Perez, Arghadip Dey, Ephraim J Vázquez-Rosado, Simon Young, Jeffrey D Hartgerink

Faculty, Staff and Student Publications

While immunotherapy is a promising treatment strategy for cancer, the majority of head and neck squamous cell carcinoma (HNSCC) patients treated with single-agent immunotherapy do not respond. Therefore, researchers are investigating combination treatments with immunostimulatory molecules that can maximize anti-tumor responses. Cyclic dinucleotides (CDNs) are STING agonists that hold promise in combination approaches, but they require frequent intratumoral administration when used in both preclinical models of HNSCC and clinical trials. To reduce administration frequency, we have created a peptide hydrogel–liposome composite system, K2-Lip(CDN), for local and prolonged availability of CDN. We investigated the loading limits of cationic liposomes in both …

H3 Dopaminylation And Camkii Modulate Diffuse Midline Glioma Response To Cdk9 Inhibition, Rebecca L Murdaugh, Brittany R Eberl, Rosemary U Richard, Ena I Campos-Hensley, Adanze N Nnyagu, W Austin Elam, Ai-Ni Tsao, Jack R Tremblay, Ruiying Ma, Alfred K Dei-Ampeh, Kieu Pham, Daniel C Kraushaar, Kwanha Yu, Calla M Olson, Akdes Serin-Harmanci, Benjamin Deneen, Jamie N Anastas

Faculty, Staff and Students Publications

Aberrant neurotransmitter signaling and transcriptional dysregulation are hallmarks of gliomagenesis and represent potential therapeutic targets. Monoamine neurotransmitters such as dopamine and serotonin primarily activate GPCRs but can also function epigenetically as histone H3 modifications. Here, we uncover mechanisms of crosstalk between monoamine neurotransmitter signaling, H3 dopaminylation, and RNA polymerase II (Pol2) transcription in diffuse midline glioma (DMG). We find that co-treatment with Pol2-targeting CDK9 inhibitors (CDK9i) and FDA-approved neuropsychiatric drugs, including selective serotonin reuptake inhibitors (SSRIs), synergistically reduces DMG growth. Mechanistically, CDK9i+SSRI treatment alters H3 dopaminylation patterns and represses synaptic and neurodevelopmental gene transcription associated with CDK9i resistance. Further phospho-proteomic …

Loss Of Znrf3/Rnf43 Unleashes Egrfr In Cancer, Fei Yue, Amy T Ku, Payton D Stevens, Megan N Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin-Hua Feng, Galen Hostetter, Xiangwei Wu, Shixia Huang, Noah F Shroyer, Bing Zhang, Bart O Williams, Qingyun Liu, Xia Lin, Yi Li

Faculty, Staff and Students Publications

ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development and cancer. Conventionally, their biological functions have been associated with regulating WNT signaling receptor ubiquitination and degradation. However, our proteogenomic studies have revealed EGFR as the protein most negatively correlated with ZNRF3/RNF43 mRNA levels in multiple human cancers. Through biochemical investigations, we demonstrate that ZNRF3/RNF43 interact with EGFR via their extracellular domains, leading to EGFR ubiquitination and subsequent degradation facilitated by the E3 ligase RING domain. Overexpression of ZNRF3 reduces EGFR levels and suppresses cancer cell growth in vitro and in vivo, whereas knockout of …

Single-Cell Tcr Mapping Reveals Spatially Coordinated T Cell States In Head And Neck Cancer, Kelli A Mccord, Emerald Kan, Sean Hyslop, Amanda Y Xia, Colby J Hofferek, James S Lewis, Andreas Wieland, David J Hernandez, Vlad C Sandulache, William H Hudson

Faculty, Staff and Students Publications

Current spatial T cell receptor (TCR) profiling approaches lack the resolution needed to link clonal identity, transcriptional state, and spatial positioning of individual T cells in the tumor microenvironment. Here, we introduce a spatial TCR profiling strategy that resolves individual T cell clones together with their transcriptional states at single-cell resolution and applied the method to human head and neck squamous cell carcinoma. Presumed tumor-specific T cells were broadly dispersed throughout the tumor microenvironment, and cells of the same clone occupied distinct transcriptional states in different locations: Immune-rich regions contained more plastic or progenitor cells, whereas tumor-dense regions were enriched …

Re-Purposing Pre-Existing Tilapia Aquaculture Open-Design System For Zebrafish Biomedical Research Purposes, Luke Cantu, David Sierra, Skyleigh Curtis, Maya Avila

ATU Scholars Symposium

Title: Re-purposing pre-existing tilapia open-design aquaculture systems for zebrafish biomedical research purposes.

Background: Zebrafish (Danio rerio) models are gaining popularity in biomedical research; however, the high infrastructure cost, at approximately $20,000 per unit, is a significant hurdle for primary undergraduate institutions (PUIs) establishing zebrafish facilities. This study assesses if repurposing existing tilapia open-design aquaculture systems could be a cost-effective method for zebrafish facility establishment.

Methods: Between November-2025 to February-2026, the study used a pre-existing tilapia aquaculture open-design system with personnel modified outlet filters. The water quality of this system was monitored and recorded. The study compared the stabilization phase or …

Maladaptive Influences Of Direct-To-Consumer Pharmaceutical Advertising: The Moderating Influence Of Age And Consumer Loneliness, Sanjay Puligadda

Atlantic Marketing Association Proceedings

No abstract provided.

Caring For Caregivers: A Health Care Marketing Opportunity, Yvette Lynne Bonaparte Dr.

Atlantic Marketing Association Proceedings

No abstract provided.

Connectivity, Classroom, And Contagion: An Ecological Analysis Of Testing Availability, Sex Education, And Sti Rates In The Upper Midwest, Macey M. Boerhave

Honors Thesis

Rural and frontier communities in the Upper Midwest face unique challenges that shape how young people access sexual health information and testing. While sexually transmitted infection (STI) rates continue to rise nationally, less is known about how sexual health education, digital access, and geographic distance influence these trends at a county level. This study examines the relationship between broadband internet access rates, poverty rates, proximity to free or low-cost STI testing sites, and county-level STI rates among individuals aged 15-24 in selected counties across South Dakota, North Dakota, Minnesota, Iowa, and Nebraska. Using an ecological, cross-sectional design, county-level STI surveillance …

Enhancing Pediatric Outpatient Occupational Therapythrough Self-Regulation Interventions, Teresa L. Marinaccio

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Enhancing Pediatric Outpatient Occupational Therapy  Through Self-Regulation Interventions

Self-regulation is defined as the understanding, acceptance, and regulation of emotional responses necessary for successful adaptation to one’s psychosocial environment, goal achievement, and overall mental health (Alarcón-Espinoza et al., 2022). This project was conducted in collaboration with two Charleston based mentors who developed a self-regulation education program with the mission to empower children and their caregivers through research-informed, trauma-sensitive strategies. The program emphasizes interoception, mindful awareness, and compassionate connection to support children in understanding their sensory needs and fostering emotional regulation.

The purpose of this project was to expand pediatric self-regulation resources …

Medication Nonadherence And Social Participation For African American Adults With Low Vision, Shakeda Mcghee, Mary Jan Greer Phd, Otr, Jaimee Fielder

Spring 2026 OTD Capstone Symposium

The concept of this capstone is to analyze how quality of life (social participation, health management) is affected in adults ages 18-55 with low vision/blindness with conditions to include diabetic retinopathy, glaucoma, and cataracts.

Identifying Major Sources Of Leptospira Interrogans In San Juan Bay And Río Grande De Loíza Estuaries Of Puerto Rico, Logan Mccullers, Dave Bachoon

Biology Theses

This study evaluated the presence of pathogenic Leptospira interrogans, potential carriers, and environmental factors influencing their occurrence in the San Juan Bay Estuary (SJBE) and Río Grande de Loíza (RGDL) watersheds of Puerto Rico from 2024–2025. Detection of this pathogen from water samples was performed using the lipL32 PCR assay. The likely hosts of L. interrogans were determined using fecal source tracking (FST) assays for human (HF-183), canine (BacCan-UCD), equine (HoF597), and rat mitochondrial DNA NADH dehydrogenase subunit 2 gene (RatMt) markers. In 2024, 91 samples were collected (March: 50; June: 41), and in 2025, 124 samples were collected …

Development And Application Of A Multiplex Bead-Based Platform For Quantifying Host-Pathogen Protein-Protein Interactions, Larah Gorayeb

Electronic Theses and Dissertations 2020 - Present

Host-pathogen protein-protein interactions are the key drivers of infectious diseases, where events such as pathogen adhesion and signaling are directly associated with disease severity. One example of this is Malaria, in which the Plasmodium falciparum infected erythrocytes adhere to endothelial receptors to avoid splenic clearance. This study investigated interactions between PfEMP1 CIDR1 field domains and host receptor CD36 using a multiplex platform to quantitatively determine binding affinities. Variants RP18 and RP27 exhibited strong affinity, suggesting a role in cytoadherence and disease severity. To evaluate broader applicability, the platform was expanded to the interaction between host protein SIVA1 and Helicobacter pylori …

Tracking Hiv Through Wastewater: Ethical Considerations In Public Health Surveillance, Faith E Fletcher, Olive R Pertuit, Catherine Troisi, Jelani Kerr, Dakotah Kinsella, Grace Elizabeth White, Steven Vargas, Anthony Maresso, Thomas P Giordano

Faculty, Staff and Students Publications

Ending the HIV epidemic requires timely identification of new HIV infections and promptly linking patients to high-quality care. Innovative methods are needed to capture real-time HIV incidence data to more effectively identify persons in need of HIV care access. Emerging advancements in wastewater surveillance (WWS) offer the potential to identify geographic areas with elevated prevalence of detectable viral loads among people who are undiagnosed or no longer receiving care, enabling more targeted interventions to reduce HIV transmission. The introduction of new public health technologies requires balancing potential risks with the significant clinical and population-level benefits of decreasing the number of …

Choice-Aya: Adapting An Evidence-Based Contraceptive Counseling Intervention For Adolescents And Young Adults Experiencing Homelessness., Mariah E. Brewe, Anna Burns, Nikolaus Schuetz, Taylor Stephens, Emma Francis, Haylie Yost, Stephani L. Stancil

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Adolescents and young adults (AYA) experiencing homelessness face an increased risk of reproductive violence, unintended pregnancy, and barriers accessing healthcare. While interventions focused on efficacy-first contraceptive counseling are successful at increasing rates of long-acting reversible contraceptive (LARC) use, little is known about how an efficacy-first approach is received by AYA experiencing homelessness given unique factors associated with their reproductive health care. We aimed to adapt the evidence-based CHOICE contraceptive counseling approach for AYA experiencing homelessness.

METHODS: Focus groups discussion with AYA experiencing homelessness were conducted to understand prior reproductive health care experiences and contraception counseling preferences, comparing efficacy first …

Reday Program 2026, Bryant University

Bryant REDay (Research and Engagement Day)

Program for the 2026 Bryant REDay (Research and Engagement Day). Program includes schedule at a glance, descriptions for panels, workshops, and presentations, along with sign-up links for specific sessions in the electronic version of the program. Printed program was in color with double-sided printing on 8 1/2" x 11" paper stapled together in the upper left corner.

The Role Of Intravascular Ultrasound Imaging In 30-Day Readmissions Among Acute St-Elevation Myocardial Infarction Patients, Britta Watson

MUSC Theses and Dissertations

Cardiovascular disease (CVD) remains one of the leading causes of death in the United States. Coronary artery disease (CAD) is the largest contributor to deaths that result from cardiovascular disease. When CAD is left untreated, it can result in an acute ST elevation myocardial infarction (STEMI). To treat coronary blockages caused by CAD, a percutaneous coronary intervention (PCI) is performed. A PCI is a non-invasive procedure that uses coronary balloons and stents to open a narrowed or blocked coronary artery and restore blood flow.

An acute ST elevation myocardial infarction (STEMI) is a major cause of early hospital readmissions. Technological …

Cognitive And Mental Health Challenges: Addressing The Impact Of Traumatic Brain Injuries In Adults, Hannah E. Smith, Lesley Khan-Farooqi, Phd, Otd, Otr, Anne Mcdonnell, Mpa, Otr/L, Cbist

Student Capstone Papers

This capstone examined the challenges adults face following traumatic brain injuries (TBIs) and explored interventions aimed at enhancing cognitive functioning and mental health. This capstone also aimed to reduce caregiver stress and burnout by expanding knowledge and resources focused on cognitive and mental health within the population. TBIs can result from a variety of causes, affecting cognitive abilities, mental health, and functional outcomes. This capstone shows evidence-based interventions designed to improve cognitive functioning, facilitate engagement in meaningful activities to improve mental health, and enhance overall quality of life for adults recovering from TBI. This also will demonstrate potential for occupational …

Nursing Migration And The Global Workforce: How The U.S. Nurse Shortage Impacts Developing Countries, Mololuwa Faithful Lasekan

Honors Thesis

As United States (U.S.) healthcare organizations face persistent staffing gaps driven by an aging population, burnout, and limited educational capacity, many institutions increasingly rely on internationally educated nurses (IENs) to stabilize their workforce. This reliance intersects with longstanding structural challenges in low- and middle-income countries (LMICs), where inadequate compensation and limited professional opportunities contribute to high migration intentions among nurses. Using a systematic literature review guided by PRISMA principles, this study synthesized evidence and five major themes emerged: (1) push factors driving nurse emigration from LMICs, (2) pull factors attracting nurses to the U.S., (3) digital globalization and post-COVID recruitment …

Sociodemographic Factors And Dating Violence Among Adolescents Living In Rural Southern U.S. Communities, Kiara Patricia Sims-Thrasher

Walden Dissertations and Doctoral Studies

Adolescent dating violence (ADV) is a significant public health issue that disproportionately affects youths in southern rural communities, yet these populations remain underrepresented in research. The purpose of this quantitative cross-sectional study was to examine the association between ADV and sociodemographic factors (gender, race, age, and education level), alcohol consumption, and bullying among adolescents in Alabama, Arkansas, and Mississippi using data from the 2021 Youth Risk Behavior Surveillance System. Guided by the social-ecological model, binary logistic regression analyses were conducted to assess relationships between ADV victimization and the selected predictors. Results indicated that females had significantly higher odds of reporting …

Relationship Between Hepatitis B Virus Screening, Vaccination, And Spread In Sierra Leone, Muhammed Sarmodu Mansaray

Walden Dissertations and Doctoral Studies

Hepatitis B virus (HBV) presents a significant public health burden in Sierra Leone. Although the estimated prevalence was 8.7% in 2021, comprehensive statistical data has been limited in general. Programmatic interventions for HBV control such as systematic screening and vaccination have remained limited as well. The purpose of this quantitative cross-sectional study was to examine the relationship between screening and vaccination practices and HBV prevalence in Sierra Leone while controlling for age, sex, education and health care access. The theoretical framework incorporated the Integrated Screening Action model, which highlights screening as a critical disease prevention strategy, and the Social Ecological …

The Association Between Advanced Technology Use And Quality Of Life Among Those With A Disability, Sarah Antus

Walden Dissertations and Doctoral Studies

Advanced medical technology use among individuals with physical disabilities remains understudied, creating a significant gap in understanding its impact on quality-of-life (QoL) outcomes across demographic and age groups. Guided by the social ecological model, the purpose of this quantitative study was to examine associations between advanced medical technology use, disability status, demographic factors (age, gender, and race/ethnicity), and QoL outcomes using 2017–2018 National Health and Nutrition Examination Survey data. The sample included 9,254 individuals age 6 years and older with physical functional limitations and complete technology-use and QoL data. Advanced medical technology use was significantly associated with improved QoL (p < .001). Disability status demonstrated a statistically significant but modest association with technology use, OR = 0.84, 95% CI [0.83, 0.85], p < .001. Age-stratified analyses indicated that advanced technology use significantly predicted improved QoL among adults aged 20 years and older, OR = 6.90, 95% CI [6.89, 6.91], p < .001, but not among youths aged 6–19 years (p = .929). Gender was a significant predictor of technology use, with females having higher odds than males, OR = 1.07, 95% CI [1.06, 1.08], p < .001. Race/ethnicity was also significantly associated with technology use; compared with non-Hispanic White adults, Mexican American (OR = 0.43, 95% CI [0.42, 0.44], p < .001), other Hispanic (OR = 0.58, 95% CI [0.57, 0.59], p < .001), and non-Hispanic Black adults (OR = 0.79, 95% CI [0.78, 0.80], p < .001) had lower odds of advanced medical technology use. The study may inform health care stakeholders about strategies to promote equitable access to advanced medical assistive technologies for social change

Bridging The Gap: At For Those With Physical Or Intellectual Disability, Rebekah Nesbitt

The 2026 Assistive Technology for Persons with Intellectual and Physical Disabilities Conference

No abstract provided.

Challenges And Opportunities To Access Assistive Technology In The Americas Region, Yasmin Garcia Mendez

The 2026 Assistive Technology for Persons with Intellectual and Physical Disabilities Conference

No abstract provided.

2026 Abstract Book (Pdf), School Of Public Health

School of Public Health Delta Omega Honors Day Poster Sessions

The collection of abstracts for the 2026 Delta Omega Honors Day Poster Session.

Noise-Induced Gains: Are You Damaging Your Hearing While You Train?, Taylor Hitschmann, Lillian Beauvais, Blake Roth, Andrew Gannon

SACAD: Scholarly Activities

This study investigated the potential risk of noise-induced hearing loss (NIHL) among individuals who listen to music during exercise. Survey data were collected alongside sound intensity measurements to better understand listening behaviors in fitness settings. Results indicated that although most participants reported listening at recommended safe levels, a notable proportion exceeded these thresholds, potentially increasing their risk of NIHL. These findings highlight the importance of monitoring listening habits during workouts. Hearing health professionals are encouraged to enhance public awareness and promote safe listening practices to help reduce the likelihood of long-term auditory damage.

The Mommy Wine Culture: A Scoping Review Using The Person-Environment-Occupational Model., Sabina Khan

Student Dissertations

Maternal alcohol use as a coping response to parenting-related stress has received growing attention in public health and psychology but remains underexplored within occupational therapy. This gap limits understanding of how daily role demands, environmental pressures, and individual vulnerabilities combine to shape drinking as a functional coping behavior. This dissertation aimed to identify and synthesize factors associated with maternal alcohol use in the context of parenting stress and interpret these determinants using the person–environment–occupation model. A scoping review was conducted following the Arksey and O’Malley framework and reported according to PRISMA-ScR guidelines. Five databases were systematically searched without date or …

Versatile Smad2 And Smad3 Epitope-Tagged Mouse Models For Genomic Profiling Of Tgfβ Signaling: Uncovering Gdf9-Smad2/3 Targets, Zian Liao, Qian Zhang, Keisuke Shimada, Kaori Nozawa, Suni Tang, Masahito Ikawa, Diana Monsivais, Martin M Matzuk

Faculty, Staff and Students Publications

Transforming growth factor β (TGFβ) signaling pathways are integral for a plethora of biological processes. SMAD2 and SMAD3 are the principal transcriptional effectors of TGFβ superfamily ligands, yet quantitative, genome-wide mapping of their DNA-associated complexes under physiological contexts has remained limited due to the lack of specific, robust models. Here, we generated two versatile epitope-tagged mouse models in which endogenous SMAD2 and SMAD3 proteins are globally tagged with hemagglutinin (HA) and podoplanin (PA) sequences, respectively, enabling high-fidelity profiling of SMAD2 and SMAD3 binding across tissues. To demonstrate the broad application of our models, we exemplified the usage of our lines …

Progesterone Receptors Drive Advanced Breast Cancer Phenotypes Including Circulating Tumor- And Stem-Like Cell Expansion In The Context Of Esr1 Mutation, Thu H. Truong, Noelle E. Gillis, Amy R. Dwyer, Rosemary J. Huggins, Kyla M. Hagen, Sai Harshita Posani, Nuri A. Temiz, Carlos Perez Kerkvliet, Ellie M. Piepgras, Julie H. Ostrander, Geoffrey L. Greene, Carol A. Lange

Department of Urology Faculty Papers

Endocrine therapy resistance remains a major challenge in the treatment of advanced estrogen receptor positive (ER+) breast cancer. This can be driven by acquired mutations in the estrogen receptor gene (ESR1), such as Y537S or D538G, that results in constitutive estrogen-independent ER activity. Progesterone receptors (PR) are important modifiers of ER activity, in part via direct binding. We previously showed that PR mediates expansion of cancer stem-like cell (CSC) populations. In this study, we sought to define whether PR function changes in the context of ESR1 mutations. PR readily interacted with wild type (WT), but not Y537S or D538G ERs. …

Examining The Differences Between Newly Married Women And Women In Long-Term Marriages. How They Experience Jealousy And Respond To Romantic Jealousy-Evoking Situations., Ernie Francis-Baptiste

Doctoral Dissertations and Projects

This quantitative correlational study, grounded on evolutionary, social role, and social-cognitive theories, and incorporating a biblical perspective, examined the differences in the experience of jealousy and responses to romantic jealousy among women within a marital context. A total of 170 participants, with 85 in each group, were recruited through convenience sampling and completed the Self-Report Jealousy Scale–Revised and the Multidimensional Jealousy Scale. The results revealed no statistically significant differences in romantic, emotional or professional experience of jealousy between the groups. Findings also revealed no statistical difference in emotional response; however, significant statistical differences were found in cognitive and behavioral responses …