Digital Commons Network^™

Volume 3, Issue 2 - Complete Issue

Wisdom & Compassion: The LUSON Journal

No abstract provided.

Determinants Of Opioid-Relevant Exposure From 7-Hydroxymitragynine Products In The Evolving U.S. Marketplace, Igor Koturbash, Scott Alsbrook, George Pro

Oxford ICSB

Kratom’s U.S. market has rapidly evolved from largely botanical powders and capsules to products enriched in 7-hydroxymitragynine (7-OH), a potent mu-opioid receptor agonist that is typically present only at trace levels in leaf material. To quantify downstream behavioral health burden and contextualize it with real-world signals of product diffusion, we analyzed National Survey on Drug Use and Health (NSDUH) data (2021-2023) alongside public health alert trends and systematic online product surveillance. In NSDUH, 5.8% of adults met criteria for serious mental illness (SMI). SMI increased by 150% among adults with combined opioid use disorder (OUD) and kratom use between 2021 …

Care, Capitalism, And Croissants: Interprofessional Students Take On Business Of Healthcare In Paris, Beth A. Komay, Phoebe S. Enebechi, Selma Dzamalija, Nicole A. Sharp

Research & Creative Achievement Day

The Business of Healthcare in Paris is a faculty-led study-away program that unites business, nursing, and other healthcare students in an immersive experience of global healthcare systems. The primary design of this course is around interprofessional learning that integrates coursework and cultural experiences from within the Midwest United States (US) and France. Students begin the course by visiting healthcare facilities and small alternative-therapy businesses in the US, gaining initial exposure to diverse care environments. They then travel to Paris and surrounding areas to explore comparable sites, including hospitals, an art therapy center, a residential rehabilitation facility, and small businesses providing …

Medicinal Plants And One Health Drug Discovery: Plectranthus Abietanes As P-Glycoprotein Modulators, Patricia Rijo

Oxford ICSB

Cancer remains a major global health challenge, with multidrug resistance (MDR)—frequently driven by P-glycoprotein (P-gp) overexpression—significantly limiting the effectiveness of chemotherapy. Within a One Health perspective, Africa, home to five major medicinal biodiversity hotspots, represents an underexplored reservoir for natural products–based drug discovery. Among this rich flora, the genus Plectranthus (Lamiaceae) emerges as a particularly promising source of bioactive abietane diterpenes. In this work, the abietane diterpene 7α-acetoxy-6β-hydroxyroyleanone (Roy), isolated from Plectranthus grandidentatus Gürke, exhibited pronounced cytotoxic activity against several cancer cell lines. To enhance its pharmacological profile, a series of Roy ester derivatives was synthesized and evaluated for their …

Quantification Of Mouse Tracheal Epithelial Cell Differentiation With Cilia Defects, Olivia V. Allen

Honors Thesis

Primary Ciliary Dyskinesia (PCD) is an autosomal recessive disorder that affects 1 in every 7,500 live births. PCD results from motile cilia defects, impairing mucociliary clearance and causing chronic respiratory infections. Our lab studies include three PCD mouse lines — bgh (Spef2), nm1054 (Cfap221), and Cfap54^gt/gt (Cfap54). Prior transcriptomic data led us to hypothesize that PCD mutant mouse tracheal epithelial cells (MTECs) exhibit reduced differentiation into ciliated cells. MTECs from the trachea of the Wild Type (WT) and the PCD mutant mouse lines were cultured at an Air Liquid Interface (ALI) to start …

The Necessity Of Adaptive Sports: Addressing Financial Barriers To Participation In Children With Spinal Cord Injuries, Megan G. Wells

Student Capstone Papers

 Children with spinal cord injuries (SCIs) experience numerous barriers to participation in adaptive sports despite the well-established physical, psychosocial, and developmental benefits of physical activity. Financial constraints, limited awareness of funding opportunities, and the complexity of grant application processes often prevent families from accessing adaptive sports programs and specialized equipment. The purpose of this doctoral capstone project was to develop a comprehensive financial guidebook for families of children with SCIs to address financial barriers to adaptive sports participation, promote physical activity, and improve overall quality of life. Guided by the Person-Environment-Occupation-Performance (PEOP) model, this doctoral capstone project addressed financial accessibility …

Historical Development Of Vaccines And The Public's Response, Kristen Montgomery, Samantha Prince Bsn, Rn, Melissa Ealey Bsn, Rn, Jarrad Morelock Bsn, Rn, Shelby Johnson Bsn, Rn, Kokeshia Crosby Bsn, Rn, Stephanies Himes Bsn, Rn, Theresia Hinton Bsn, Rn

Epsilon Sigma at-Large Research Conference

Purpose: Vaccines, which have become one of the most important medical accomplishments in the prevention of communicable diseases, have a history that dates to the use of variolation as early as the 11th century. The purpose of this study is to explore the historical development of vaccines and to determine the characteristics that emerged when new vaccines were developed.

Aims: The specific aim of this study is to understand if all vaccines have been received about the same by the general public or if there are certain different or diverse characteristics associated with the introduction of different vaccines.

Methods: A …

A Systematic Literature Review Examining Suicide Risk Factors In Older Adults, Carolyn Bivens

Epsilon Sigma at-Large Research Conference

Introduction & Background: Suicide in older adults is a increasingly prevalent tragedy worldwide, and rates in North America have uniquely increased over the past two decades. The context of the cultural environment of North America and population-specific factors in the elderly must be explored to protect this vulnerable group.

Purpose Statement Question: In older adults living in North America, what experiences and risk factors influence the development and severity of suicidal thoughts and behaviors?

Literature Review: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart guided the search of the Cumulative Index to Nursing and Allied Health Literature …

Using Path Analysis To Examine The Psychological Well-Being Model For U.S. College Students, Pi-Ming Yeh, Cheng-Huei Chiao, Gavin Waters

Epsilon Sigma at-Large Research Conference

Background: College students’ psychological well-being and mental health issues are very important in this society. Little is known about a comprehensive psychological well-being model for college students.

Purpose: The purpose of this study was using Path Analysis to examine the Development of Personality and Psychological Well-Being Model among US college students.

Methods: This was a cross sectional, descriptive design. The 481 participants were recruited from nursing and business college students in the United States. After IRB approval, the trained researchers explained this study to college students. After agreeing to participate, they signed an informed consent form. Upon completion of a …

Occupational Therapy For Maternal Pelvic Floor And Mental Health: A Holistic Approach To Recovery, Diana S. Theodore

Student Capstone Papers

Maternal pelvic floor dysfunction (PFD) is highly prevalent yet often underrecognized in occupational therapy practice, despite its significant impact on mental health, daily function, and quality of life. Many postpartum women experience symptoms such as urinary incontinence, pain with intimacy, and pelvic organ prolapse, which are frequently normalized or left untreated. Occupational therapy practitioners often have limited training in addressing the complex relationship between pelvic floor function and maternal mental health, contributing to gaps in care. The purpose of this capstone project was to develop a comprehensive handbook for occupational therapy students and practitioners integrating pelvic floor function and maternal …

The Impact Of Covid-19 On Quality Of Care In Hospital Settings, Sophia Callahan

Health Sciences Student Scholarship

No abstract provided.

Improving Pneumococcal Immunization Counseling In Children With Systemic Lupus Erythematous, Sarah Dettmann

Doctoral Dissertations & Projects

Background: Pediatric patients with systemic lupus erythematosus (SLE) face elevated risk for invasive pneumococcal disease, yet fewer than 10% are estimated to be current on pneumococcal vaccine (PCV) recommendations.

Local Problem: This quality improvement (QI) project aimed to develop and implement a standardized pneumococcal immunization screening and counseling process in a pediatric rheumatology clinic.

Method: Three consecutive PDSA cycles guided implemention across a nine-week intervention period using a pre-post quasi-experimental design.

Interventions: A multicomponent strategy was employed, including a PCV decision algorithm, EHR Smart Phrase, PCP referral template, and patient education brochure.

Results: Pre-implementation PCV counseling was documented …

Ai And Algorithmic Literacy Among Health Workers: A Scoping Review Through A Digital Health Literacy Lens, Ihoghosa Iyamu, Carly Wheelans, Devon Haag, Ian Roe, Hsiu Ju Chang, Lorie Donelle Phd, Rn, Fcan, Faan, Ursula Ellis, Geoffrey Mckee, Sofia Bartlett, Mark Gilbert

Publications

Introduction – Artificial intelligence (AI) and algorithmic systems influence health workers’ access, interpretation, and action on clinical and public health information, positioning them as intermediaries between algorithmically mediated outputs and patients, communities, and decision makers. This study examines how AI and algorithmic literacy are conceptualized and measured among health workers through a digital health literacy (DHL) lens. Methods – Using Arksey and O’Malley’s scoping review framework, we searched Ovid MEDLINE, Ovid Embase, Scopus, IEEE Xplore, ACM Digital Library, Europe PMC, and arXiv for English language sources published between January 2020 and May 2025. Two reviewers screened records and extracted data …

The New Era Of Pulmonary Hypertension: The Dawn Of Disease Modification & Therapeutic Modalities, Noyan Ramazani, Lacey Barnes, Alex Wong, Divyansh Sharma, Aditi Singh, Kachon Lei

Department of Internal Medicine Faculty Research

Pulmonary hypertension (PH) can be defined as a mean pulmonary artery pressure (mPAP) greater than 20 mm Hg at rest during right heart catheterization (RHC). The reported prevalence of PH throughout the globe has been estimated to impact approximately 1% of the total population, with a majority of those afflicted being women more than men. Numerous etiologies give rise to the pathophysiology of PH, including heart disease (i.e., left-sided heart failure), lung diseases, and other unclear causes related to chronic stages and complications surrounding long-standing pulmonary thromboembolisms, side effects of certain medications, and genetic and environmental factors. Untreated PH can …

Muc13-Associated Molecular Interactome In Pancreatic Cancer, Anupam Dhasmana, Swati Dhasmana, Rajasekhar Baru, Abigail Gomez, Shafiul Haque, Sheema Khan, Murali Yallapu, Subhash Chauhan

School of Medicine Publications

Mucin-13 (MUC13) has emerged as a critical molecular player involved in tumorigenesis, cancer progression, metastasis, and evasion of immune surveillance, including in pancreatic cancer. In this report, we identified MUC13 molecular interactome using an integrated immunoprecipitation and liquid chromatography–mass spectrometry (accession no. of protein data JPST004189) approach combined with systems network biology to determine its plausible functional protein–protein interaction network and associated oncogenic mechanisms. This study reveals a total of 54 key MUC13 interactor proteins (including cyclin-dependent kinase 1, catenin delta 1, Caludin-1, ErbB3-binding protein 1, basic transcription factor 3, tight junction protein 1, etc.). Interestingly, the majority of these …

Delivering Safe Sleep And Breastfeeding Education To Pregnant And New Mothers Through Private Facebook Groups: Study Protocol For A 4-Armed Randomized Controlled Trial, Rebecca F Carlin, Margaret G Parker, Ann L Kellams, Fern R Hauck, Stephen Kerr, Benjamin T Cornwell, Marc T Kiviniemi, Nicole Geller, Katherine E Boguszewski, Michael J Corwin, Eve R Colson, Rachel Y Moon

2020-Current year OA Pubs

BACKGROUND: Annually, more than 3500 US infants die suddenly and unexpectedly. Many sudden unexpected infant deaths (SUID) are preventable with greater adherence to safe infant sleep guidelines. There are racial and economic disparities in guideline adherence and SUID rates. Education alone has proven ineffective at altering behavior for many parents, and social networks and social norms regarding infant care have been found to influence rates of unsafe sleep. Using the power of social networks to shape social norms by delivering education through moderated online social media groups provides a unique opportunity to influence these practices in large groups of parents. …

Lessons Learned For Improving Trainee Engagement And Utilization Of Education And Training Materials For Cancer Research, Katerina M. Santiago, Tania Galindo, Michaela A. Dinan

Advances in Cancer Education and Quality Improvement

Background: A core component of the National Cancer Institute Cancer (NCI) Cancer Center Support Grant requires cancer centers to coordinate research career enhancement and related activities. The Yale Cancer Center, an NCI-designated comprehensive cancer center, established the Cancer Research Training and Education Coordination (CRTEC) component in 2016. In response to the needs of trainees, CRTEC has developed several initiatives that we have identified and described here as best practices to engage and support trainees.

Methods: We had 2 aims to improve engagement: 1) increasing our visibility and trainee awareness of CRTEC and nurturing bidirectional communication and 2) offering …

Centralizing Communication Intake To Improve Workflow Visibility And Engagement: A Quality Improvement Project In A Cancer Center's Education Division, Menatalla El-Sharkawi, Mohamed Ait Aiss

Advances in Cancer Education and Quality Improvement

Background: In large or complex organizations, multiple teams may be charged with managing different components of a project, initiative, or administrative assignment. When these teams have overlapping needs for information, the absence of a structured intake and tracking process can limit transparency, reduce efficiency, and hinder coordination across communication channels.

Methods: Drawing on principles of strategic communications and project management, we created a structured and centralized information sharing process for teams within the education division of a comprehensive cancer center. The intervention included workflow redesign, development of a standardized intake system, and use of real-time dashboard analytics to support operation …

Yeast As A "Microbial Factory", Kaila Fuller, Betsy Jean Yakes

Oxford ICSB

Yeast are eukaryotic, single-celled microorganisms that are members of Kingdom Fungi, and in the world of dietary supplements, yeast qualify as a dietary ingredient as a botanical. During fermentation, yeast naturally produce byproducts that can be harvested, purified, and sold in a dietary supplement. Advances in biotechnology have allowed for genetic modification of yeast so that yeast can produce large quantities of native or non-native constituents during fermentation, effectively making yeast a “microbial factory” for various chemicals. Chemicals produced this way can qualify as a dietary ingredient as a constituent of a botanical. Relevant examples of past submitted notifications (public …

Silent Struggles: A Qualitative Study On Mental Health Stigma And Help- Seeking Among African Individuals In The U.S, Ololade Ekwere

Dissertations

Approximately one-third of African Americans and Caribbean Blacks who require mental health services seek and utilize them (Evans & Sheu, 2019). Research has shown that stigma surrounding mental health treatment contributes to lower rates of professional help-seeking among Black Americans (Pederson, 2023). Despite the growing diversity within the Black community, limited research exists on how stigma influences professional mental health help-seeking among Africans living in the United States.

The purpose of this qualitative descriptive study was to explore the effect of public stigma on the mental health help-seeking behaviors of Africans living in the United States. Demographic data were collected, …

Developing Inclusive, Evidence-Based Curriculum And Educational Resources For Neurodiverse Learners, Cristina N. Cinca

OTD Capstone Projects

This doctoral capstone was completed in partnership with Wildflower Learning Center in Nolensville, Tennessee, a non-traditional educational program offering group academic classes within an inclusive and supportive learning environment for children with disabilities, neurodiverse learners, and neurotypical peers in grades 3–8. Wildflower Learning Center utilizes an interdisciplinary model that supports academic, social, language, and functional skill development through group-based instruction. The primary goal of this project was to develop an inclusive, evidence-based curriculum aimed at enhancing students’ interoceptive awareness through structured lesson plans, engaging activities, and supportive educational resources. A comprehensive 14-week brain class curriculum was created in both digital …

Relationships Between Adolescents With Substance Use Disorders, Their Guardians, And Expressive Arts Therapy: A Literature Review, Sarah K. Unkefer

Expressive Therapies Theses

This literature review collects the comprehensive, current research around effective treatment of adolescents with substance use disorder (SUD) and explores ways to provide psychoeducation for the adolescent and their guardians to foster healthy relationships and open communication. This author explores the ways that expressive arts therapy influences treatment and long-term recovery of adolescents with substance use disorders (SUDs) by addressing familial communication and internalized stigma. Previous studies have shown that the current primary reaction from guardians is forcing abstinence, which often damages the adolescent-guardian relationship. Since this is one of the most important relationships in an adolescent’s projected recovery journey, …

Supporting Self-Regulation In Early Childhood Through Parent–Child Movement And Sensory Play, Meris Gilliam

OTD Capstone Projects

The focus of this capstone was to develop a parent–child movement and sensory play program for Nurture Nashville, a local yoga and wellness studio focused on promoting holistic well-being and community connection. The program consisted of a four-week movement and music-based class for preschool-aged children and their caregivers, designed to support self-regulation, motor development, and social interaction through play-based activities. The program also emphasized caregiver education to promote co-regulation strategies and strengthen parent–child connection beyond the class setting.

Navigating Screens For Neurodivergent Individuals, Avery Wilson

Honors Theses

As technology becomes more prevalent in everyday life, it is important to consider the implications that this may have for one's mind and well-being. These implications are particularly important for vulnerable populations, such as neurodivergent individuals, who may have unique sensitivities to technology consumption. This paper reviews current literature to provide an overview of the implications of using media on the neurodivergent population, such as individuals with Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD), who often possess unique brain sensitivities that influence technology consumption.

To begin, the paper examines the changes in brain structure and functioning in children …

Changes In Internet Search Term Popularity In Elder Mistreatment (2018-2023): Infodemiology Study Of Google Trends Data, Nicholas Sevey, Melvin Livingston, Kristin Lees-Haggerty, Olanike Ojelabi, Randi Campetti, Jason Burnett, Carolyn E Z Pickering, David Hancock, Rachit Sabharwal, Michael Brad Cannell

Faculty, Staff and Student Publications

Background: Elder mistreatment (EM) is a significant public health problem that is frequently underdetected and underreported. Insufficient public recognition and engagement have been hypothesized as one contributor to this underreporting; however, few data sources exist to quantify public awareness or engagement with EM at the population level.

Objective: This study examined relative internet search interest in EM compared with other forms of abuse (child abuse and domestic violence) in the United States using Google Trends data.

Methods: We analyzed Google Trends data to compare the Relative Search Index (RSI) for the terms "elder abuse," "child abuse," and "domestic violence" in …

Construction And Characterization Of Novel Mycobacterium Tuberculosis-Derived Triple And Quadruple Knockout Vaccines Against Tuberculosis, Omar Garnica, Raja Veerapandian, Kishore Das, Abhishek Mishra, Varsha Rawat, Areanna Carmona, Vivek Chauhan, Rakesh Kumar, Jessica Chacon, Shrikanth S. Gadad, Subramanian Dhandayuthapani

School of Medicine Publications

Tuberculosis (TB) is a deadly disease that claims the lives of over a million people each year worldwide. The Bacille Calmette-Guérin vaccine has long been used to protect against TB, but it produces variable effects across different populations and fails to protect against adult pulmonary TB. Therefore, there is an urgent need for alternative vaccines that can offer better protection. We have developed a strategy for the rational deletion of virulence-related genes in Mycobacterium tuberculosis (Mtb) to create hyperattenuation that also enhances immunogenicity. Previously, we generated both single (∆fbpA) and double knockout (DKO) (∆fbpA-∆sapM) mutants of …

Application Of Aqbd Principles To Build A Robust Compendial Analytical Method For The Quantification Of Phytochemicals In Mate And Guayusa Leaf Dietary Ingredients, Maria Monagas, Salika Jeelani, Greg Winter, Natalia Kouznetsova

Oxford ICSB

Mate (Ilex paraguariensis) and Guayusa (Ilex guayusa), both members of the Aquifoliaceae family, have traditionally been consumed as herbal teas in South America. Their leaves are rich in methylxanthines and hydroxycinnamoylquinic acids—quinic acid derivatives of caffeic and gregrferulic acids—which provide stimulant and antioxidant properties. These compounds make them valuable for use in health and energy beverages as well as dietary supplements. We applied the Analytical Quality-by-Design (AQbD) approach to develop a robust UHPLC method for simultaneous quantification of methylxanthines and hydroxycinnamoylquinic acids. The method and sample preparation were designed in alignment with USP General Chapter < 1220> Analytical Procedure Life Cycle and …

Windshield Not The Rearview Mirror, Dan Fabricant

Oxford ICSB

We talk a great deal about the past at ICSB and while the history is important, we still need to skate to where the puck is going. We’ll tee up where we are and where we are going when it comes to: drug preclusion; federal preemption; state regulatory efforts; hemp/cannabis; electronic commerce platforms; claims; essentiality; and much more, like what you can do to affect real change for the future of the industry.

A Joint Effort: Accomplishments Of The Resource Center For Cannabis And Cannabinoids Research, Patrick Still, Don Stanford, Mary Paine, Nandakumara Sarma

Oxford ICSB

No abstract provided.

Creating Engaging Activities To Improve Overall Group Participation Within Centennial Adultcare Center, Ava Woessner

OTD Capstone Projects

This doctoral capstone project was conducted in collaboration with Centennial Adultcare Center, an adult day program that is dedicated to providing a stimulating and supportive environment for personal growth and independence through professional care within a reasonable fee. The center serves a variety of diagnosis including but not limited to: dementia, cerebral palsy, intellectual and developmental disabilities (IDD), stroke, and autism. The primary objectives of this project were to develop engaging, member-focused activities through the use of graded interventions and adaptive equipment, provide staff members with effective resources, and enhance the visibility and promotion of adult day services through social …