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Department Of Veterinary And Biomedical Sciences: 2006 Annual Report

School of Veterinary and Biomedical Sciences: Information and History

Department of Veterinary and Biomedical Sciences Personnel . 9-16

Faculty .. 9

VBMS Researchers, Postdoctoral and Senior Research Associates . 10

VBMS Adjunct and Courtesy Faculty .... 11

Emeriti Faculty .. 11

VBMS Faculty and Staff by Function and Unit .. 9-16

VBMS Honors, Awards and Recognitions, 2006 17-19

VBMS Committee Assignments, 2006/2007 . 20-22

Faculty Profiles . 23-45

Raul G. Barletta, BS, MS, PhD .. 23

Bruce W. Brodersen, BS, DVM, MS, PhD .... 24

Michael P. Carlson, BS, MS, PhD ... 25

Subash Das, BSV c, MVSc, PhD .... 26

Alan R. Doster, DVM, MS, PhD, ACVP . …

Hla Alleles Associated With Delayed Progression To Aids Contribute Strongly To The Initial Cd8+ T Cell Response Against Hiv-1, Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathais Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, Bruce D. Walker

United States Public Health Resources

Background

Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression.

Methods and Findings

In a cohort of 104 individuals with primary HIV-1 infection, we demonstrate that a subset of CD8⁺ T cell epitopes within HIV-1 are consistently targeted early after infection, while other epitopes subsequently targeted through the same HLA class I alleles are rarely recognized. Certain HLA alleles consistently contributed more than others to the total virus-specific CD8⁺ T cell response during primary infection, and also reduced …

Serum Decreases The Size Of Metafectene- And Genejammer-Dna Complexes But Does Not Affect Significantly Their Transfection Activity In Sccvii Murine Squamous Cell Carcinoma Cells, Krystyna Konopka, Nathan Overlid, Anitha C. Nagaraj, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

Cationic liposome-DNA (lipoplexes) or polymer-DNA (polyplexes) complexes have been used to deliver therapeutic genes, both in vitro and in vivo. However, gene transfer by these non-viral vectors is usually inhibited by biological milieu. A relatively high efficiency of transfection could be achieved in human oral cancer cells transfected with the polycationic liposome, Metafectene, and the polyamine reagent, GeneJammer, in the presence of 60% fetal bovine serum (FBS) (Konopka et al., Cell. Mol. Biol. Lett. 10 (2005) 455-470). Here, we examined the efficacy of these vectors to deliver β-galactosidase (β-gal), luciferase and Herpes Simplex Virus thymidine kinase (HSV-tk) genes to SCCVII …

College Of Optometry Overview 2006, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Bachelor Of Health Science-College Of Allied Health And Nursing 2006, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Meaningful Labeling Of Integrated Query Interfaces, Eduard Dragut, Clement Yu, Weiyi Meng

Cyber Center Publications

The contents of Web databases are accessed through queries formulated on complex user interfaces. In many domains of interest (e.g. Auto) users are interested in obtaining information from alternative sources. Thus, they have to access many individual Web databases via query interfaces. We aim to construct automatically a well-designed query interface that integrates a set of interfaces in the same domain. This will permit users to access information uniformly from multiple sources. Earlier research in this area includes matching attributes across multiple query interfaces in the same domain and grouping related attributes. In this paper, we investigate the naming of …

Optimal Therapy Regimens For Treatment-Resistant Mutations Of Hiv, Weiqing Gu, Helen Moore

All HMC Faculty Publications and Research

In this paper, we use control theory to determine optimal treatment regimens for HIV patients, taking into account treatment-resistant mutations of the virus. We perform optimal control analysis on a model developed previously for the dynamics of HIV with strains of various resistance to treatment (Moore and Gu, 2005). This model incorporates three types of resistance to treatments: strains that are not responsive to protease inhibitors, strains not responsive to reverse transcriptase inhibitors, and strains not responsive to either of these treatments. We solve for the optimal treatment regimens analytically and numerically. We find parameter regimes for which optimal dosing …

Importing Extended Producer Responsibility For Electronic Equipment Into The United States, Chad Raphael, Ted Smith

Communication

Extended Producer Responsibility (EPR) is a policy approach that holds manufacturers accountable for the full costs of their products at every stage in their life cycle. EPR typically involves requiring that producers take back their products at the end of their useful lives, or pay a recycling contractor to do so, thereby internalizing the costs of recycling or disposal in a manufacturer’s bottom line. When companies know that they will bear the costs of product return and recycling, they are more likely to redesign their products for easier and safer handling at each step in the life cycle. This approach …

Development Of Dose Coefficients For Radionuclides Produced In Spallation Targets, Phillip W. Patton, Mark Rudin

Transmutation Sciences Physics (TRP)

Dose coefficients permit simple determination of radiation dose associated with various exposure scenarios, and ultimately permit radiation safety personnel to assess the health risks to workers in a nuclear facility. Specifically, radiation safety personnel use dose coefficients to determine the radiation dose incurred to a tissue or organ system from a given exposure. These parameters are often expressed in terms of Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs).

The research consortium comprised of representatives from several universities and national laboratories has successfully generated internal and external dose conversion coefficients for twenty radionuclides produced in spallation neutron sources. …

Dentalgram - Vol. 20, No. 01, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• Remembering the lives of Dr. Ronald Blank, Robert Kinzer, and Albert Burns
• LLUSD students co-chairs national conference
• School of Dentistry to host Investment Fair
• Department news
• New director of biomaterials research laboratory invites faculty to participate in research
• James Crawford presented with Medal of Distinction by General Conference of Seventh-day Adventists
• Banquet held for December, 2005 International Dentist Program graduates

A Retrospective, Descriptive Study Of Shoulder Outcomes In Outpatient Physical Therapy, A. Lynn Millar, Philip A. Jasheway, Wendy Eaton, Frances Christensen

Faculty Publications

Study Design: A retrospective, descriptive study of clients with shoulder dysfunction referred to physical therapy. Objectives: To (1) describe the clinical and functional outcomes of clients with shoulder dysfunction following outpatient physical therapy, and (2) to compare the outcomes by type of shoulder dysfunction. Background: Although individuals with shoulder dysfunction are commonly referred to physical therapy, few large descriptive studies regarding outcomes following physical therapy are available. Methods and Measures: Data for 878 clients (468 female, 410 male) were retrieved and analyzed. This database was developed between 1997 and 2000 and included 4 outpatient facilities from 1 healthcare system in …

K-Spmm: A Database Of Murine Spermatogenic Promoters Modules & Motifs, Yi Lu, Adrian E. Platts, G Charles Ostermeier, Stephen A. Krawetz

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Understanding the regulatory processes that coordinate the cascade of gene expression leading to male gamete development has proven challenging. Research has been hindered in part by an incomplete picture of the regulatory elements that are both characteristic of and distinctive to the broad population of spermatogenically expressed genes.

Description

K-SPMM, a database of murine Spermatogenic Promoters Modules and Motifs, has been developed as a web-based resource for the comparative analysis of promoter regions and their constituent elements in developing male germ cells. The system contains data on 7,551 genes and 11,715 putative promoter regions …

Horizontal Subsurface Flow Constructed Wetlands For On-Site Wastewater Treatment, Boyd C. Hoddinott

Master of Public Health Program Student Publications

Horizontal subsurface flow constructed wetlands (SSFCWs) are being used worldwide to treat wastewater from a variety of sources. An extensive literature review was conducted to update the current state of scientific knowledge on the performance of SSFCWs for domestic wastewater treatment. This review documented good treatment efficiency for the five commonly measured parameters (TSS, BOD, nitrogen, phosphorus, and fecal coliforms).

An attempt at a Meta analysis turned up a myriad of problems preventing a proper statistical review. These include lack of adherence to standard methods for effluent analysis, varying metrics for reporting treatment efficiency, variability in the nitrogen species which …

A Holistic Self-Identity Model, Jacquelyne R. Joens

Graduate Research Papers

Parents, educators, business leaders, political leaders, and mental health professionals all appreciate the impact positive self-esteem has on a person's ability to strive and grow. Self-esteem is a complex, multifaceted component of human existence. It is possible to identify and observe the result of a healthy self-esteem or even the outcome of a damaged self-esteem, but the term self-esteem may be antiquated and no longer exemplary of a complete picture of self. This paper examines research and attempts to define a multi-dimensional model of self-esteem, a Holistic Self-Identity Model, which will help to bring into focus the concept of self-identity …

Information Systems And Health Care Xiii: Examining The Critical Requirements, Design Approaches And Evaluation Methods For A Public Health Emergency Response System, Ann L. Fruhling

Information Systems and Quantitative Analysis Faculty Publications

Research pertaining to emergency response systems has accelerated over the past few years, particularly since 9/11 events, and more recently due to Hurricane Katrina and concern over a potential of an avian flu pandemic. This study examines the requirements that are the most demanding with respect to software and hardware, and the associated design strategies for a public health emergency response system (ERS) for electronic laboratory diagnostics consultation. In addition, this study illustrates ways to evaluate the design decisions.

An important goal of a public health ERS is to improve the communication and notification of life-threatening diseases and harmful agents. …

Preparation Of Some Substituted Terephthalic Acids, Susanna Branion, Vladimir Benin

Chemistry Faculty Publications

We report in detail the preparation of two substituted terephthalic acids: 2‐sulfomethylterephthalic acid (1) and 2‐phosphonoterephthalic acid (2). Efficient, short syntheses have been developed for both compounds. They are potentially useful monomers for construction of acid‐pendant polymer chains.

Preparation, Characterization And Dft Studies Of Some New N-Nitrosocarbamates And N-Nitrosoureas, Ragavan Narayanan, Helene Hedian, Eric Shamo, Vladimir Benin

Chemistry Faculty Publications

We are presenting the preparation, characterization and density functional theory (DFT) studies {B3LYP/6-31+G(d)) of several reiated classes of N-nitrosocarbamates and N-nitrosoureas. The iong-range goal is the design and preparation of compounds, which would undergo photochemical or hydrolytic decomposition, to yield stabilized cyclic cations that can serve as alkylating agents at various nucleophilic centers, including DNA bases.

Safe Motherhood Applied Research And Training (Smart) Report 3: Changes In Knowledge And Behavior Of Women And Families, Muhammad Shafique Arif, Peter C. Miller, Nayyer Munir, Irfan Masood

Reproductive Health

The Safe Motherhood Applied Research and Training (SMART) project was conceived as an operations research project designed to test the effectiveness of two different strategies for improving maternal and neonatal health in Pakistan. To evaluate the results of this test, several types of evaluative research were conducted, including qualitative studies of various types, health systems assessments, evaluations of specific components, and household surveys. The household surveys are the subject of this report, which is Report 3 (Changes in knowledge and behavior of women and families) in a series of six. The surveys are two types: a large-scale, before-after household survey …

Strategies For Encouraging The Abandonment Of Female Genital Cutting In West Africa: Experiences From Senegal, Burkina Faso, And Mali, Nafissatou J. Diop, Ian Askew

Reproductive Health

This article explores efforts to encourage abandonment of female genital cutting (FGC) in Senegal, Burkina Faso, and Mali. The strategy of encouraging traditional practitioners to stop performing FGC is not effective as community-level support for the practice remains high. Training health staff significantly improved healthcare providers' levels of knowledge about FGC and its complications. Consequently, it was recommended that such training be incorporated into preservice medical training. The use of community-based strategies like the Village Education Program (VEP) showed the most promise, as their multifaceted approach addresses knowledge, attitudes, actions, and communal support in an integrated manner. The way forward …

Characterization Of Perphenazine And Scopolamine Aerosols Generated Using The Capillary Aerosol Generator, Xihao Li

Theses and Dissertations

The characterization of perphenazine and scopolamine aerosols generated using the capillary aerosol generator (CAG) was reported. Variables including steady state power, the formulation vehicle, the drug concentration and the formulation flow rate were studied for their effects on the chemical stability and particle size of these drug aerosols.Stability-indicating HPLC and LC-MS assays were developed and validated for perphenazine and scopolamine, respectively. The chemical stability of each compound was investigated under a variety of stress conditions and the structure of degradation products was proposed.Perphenazine aerosols were generated from propylene glycol (PG) formulations with concentrations of 9, 48 and 90mM at formulation …

Impact Of Lowering The Permissible Exposure Value For Formaldehyde: Health Impact Of An Occupational Exposure To Formaldehyde, Gaétan Carrier, Michèle Bouchard, Nolwenn Noisel, Yvette Bonvalot, Sandra Fradet

Rapports de recherche scientifique

Cliquez ici pour la version française de ce rapport

Ce document est une annexe du rapport Impacts d'un abaissement de la valeur d'exposition admissible au formaldéhyde (R-386)

This document is an annex to the report Impacts d'un abaissement de la valeur d'exposition admissible au formaldéhyde (R-386)

Relationships Among Stress, Blood Pressure, And Heart Rate Variability In Meditators, Sangthong Terathongkum

Theses and Dissertations

PROBLEM STATEMENT: Growing evidence indicates that psychological stress contributes to cardiovascular diseases through complex neuroendocrine mechanisms. Psychological stress leads to several physiological responses including increased heart rate (HR) and blood pressure (BP) as well as decreased heart rate variability (HRV) through alterations in the autonomic nervous system (ANS), specifically increased sympathetic nervous system (SNS) activity and decreased parasympathetic nervous system (PNS) activity. Meditation is thought to induce an innate relaxation response leading to reduced psychological stress. Findings from past studies have provided inconclusive evidence regarding the direction and strength of relationships among stress, BP, HRV, and meditation practice. PROCEDURES: A …

Understanding The Nature Of Surgical Excellence Using A Competency Modeling Approach, Hope S. Hanner-Bailey

Psychology Theses & Dissertations

Currently, a thorough description of the knowledge, skills, abilities, and other personal characteristics (KSAOs) that distinguish an exceptional surgeon does not exist. This knowledge is pertinent to the development of selection, training, and performance assessment methods that can be used to develop high performing surgeons. Expert surgeons from around the country were recruited to participate in an interview to discuss the KSAOs (i.e., the competencies) needed to be exceptional in the field. A smaller number of novice surgeons were also interviewed. The expert interview data were distilled into a competency model that consists of ten competencies and patterns within the …

There Is More To Vision Than Seeing Clearly, Dawn Cardinal, Genea Nannemann

Occupational Therapy Capstones

"Vision is not simply the ability to read a certain size letter at a distance of 20 feet. Vision is a complex and adaptable information gathering and processing system which collects, groups, analyzes, accumulates, equates, and remembers information" (American Optometric Association, 2005, p.1). The purpose of this project is to develop a parent/caregiver handbook that will educate parent/caregivers with children who have visual deficits and to benefit the Vision Therapy Project, which is located in Casper, Wyoming. This project is a non-profit organization dedicated to provide assistance and education to parents/caregivers with children in need of vision therapy. Information for …

Recreational Manual For Caregivers Of Individuals With Cerebral Palsy, Erica Bucher

Occupational Therapy Capstones

A brief literature review was conducted on cerebral palsy to gain general information and statistics. After reviewing the literature, it was noted that there is a significantly high number of children diagnosed with cerebral palsy each year. These individuals are at a high risk to experience the lack of opportunity for a wide choice of recreational activities. To understand the magnitude of the problem an extensive literature review was done on this topic. It was found that the lack of access and participation in independent recreational opportunities may lead to the development of dependent behavioral patterns, learned helplessness and depression. …

Giving All Children A Good Start To School: A Protocol In Defining Occupational Therapist's Role In School Readiness, Specifically In The Smart Program, Melissa Boll

Occupational Therapy Capstones

More children are entering school "not ready." Current research is showing that many "healthy" children are entering school not developmentally ready for formal learning. Based my own experiences working as a school occupational therapist for the past four years in rural area schools, this new trend is becoming more apparent. Teachers and other school professionals have increasing concerns over the numbers of children that seem "clumsy" or "awkward" compared to their peers. Children are expected to learn more than ever before upon entering school, the curriculum is no longer age-appropriate due to the pushing down of academics. Upon entrance to …

Temporal Processing In The Exponential Integrate-And-Fire Model Is Nonlinear, Joanna R. Wares, Todd W. Troyer

Department of Math & Statistics Faculty Publications

The exponential integrate-and-fire (EIF) model was introduced by Fourcaud-Trocme et al. (2003) as an extension of the standard leaky integrate-and-fire model (LIF). Here, the nonlinearity in the EIF model’s temporal response to square-wave inputs is investigated. Comparing the time course of onset and offset responses revealed that offset responses have a steeper initial slope, but a slower approach to equilibrium. A linear systems analysis performed for these square-wave inputs indicates that at frequencies above ~40 Hz, gain was slightly smaller for square-wave inputs, but phase did not change significantly relative to simulations in which the corresponding sinusoids were presented in …

Sulcular Sulfide Monitoring: An Indicator Of Early Dental Plaque-Induced Gingival Disease, Aleksandra Pavolotskaya, Gayle Mccombs, Michele Darby, Kenneth Marinak, Naik N. Dayanand

Dental Hygiene Faculty Publications

Purpose. The purpose of this study was to evaluate the relationship between volatile sulfur compounds (VSC) and gingival health status and to determine if volatile sulfur compounds can detect early dental plaque-induced gingival disease. Methods. A split-mouth design with randomly selected quadrants of the mandibular arch enabled 39 participants to serve as their own controls. At baseline and at three subsequent appointments (days 7, 14, and 21) gingival inflammation (GI), bleeding on probing (BOP), and sulfide levels (SUL) were measured using the Gingival Index and the Diamond Probe/Perio 2000 System. For three weeks, participants refrained from brushing and flossing one …

Potential Of Vibrational Spectroscopy In The Diagnosis Of Human Tumours., Eoghan O'Faolain

Doctoral

Just fewer than 20,000 people are annually diagnosed with some form of cancer in Ireland and one in three people are likely to contract some form of cancer by age 74. With the number of cases increasing at an annual rate of 2%, the early detection and treatment of cancer is becoming increasingly important. Both IR and Raman spectroscopy offer the potential for real time, quantitative detection of cancer and even precancer. This study investigates the potential of Raman and Fourier transform infrared, both benchtop and synchrotron spectroscopies for the detection of cervical cancer. The tissue was classified and its …

Efficient Pairwise Rna Structure Prediction And Alignment Using Sequence Alignment Constraints, Robin D. Dowell, Sean R. Eddy

Open Access Publications

No abstract provided.