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Articles 1381 - 1410 of 23195
Full-Text Articles in Entire DC Network
Amyloid Accumulation, Brain Atrophy, And Cognitive Decline In Emergent Alzheimer's Disease, Ying Xia, Pierrick Bourgeat, Vincent Doré, Jurgen Fripp, Yen Ying Lim, Simon M. Laws, Christopher Fowler, Christopher C. Rowe, Colin L. Masters, Elizabeth J. Coulson, Paul Maruff
Amyloid Accumulation, Brain Atrophy, And Cognitive Decline In Emergent Alzheimer's Disease, Ying Xia, Pierrick Bourgeat, Vincent Doré, Jurgen Fripp, Yen Ying Lim, Simon M. Laws, Christopher Fowler, Christopher C. Rowe, Colin L. Masters, Elizabeth J. Coulson, Paul Maruff
Research outputs 2022 to 2026
Introduction : Emergent Alzheimer's disease (AD) represents a transitional stage where cognitively unimpaired (CU) individuals exhibit subthreshold but increasing amyloid-β (Aβ) levels. The impact of Aβ accumulation on brain volume loss and cognition during this early stage remains unclear. Methods: This retrospective cohort study analyzed data from 408 CU participants who were initially Aβ− (< 15 Centiloids) and followed for up to 15 years. Changes in basal forebrain and hippocampal volume, along with domain-specific cognitive performance, were compared between those who progressed to Aβ+ (≥20 Centiloids) and those who remained Aβ−. Results: Sixty-five CU participants progressed to Aβ+, indicating emergent AD, and showed faster Aβ accumulation and subtle memory decline. However, no significant differences in rate of BF and hippocampal atrophy were observed between groups. Discussion: The results suggest that during this emergent phase of AD, Aβ accumulation is associated with episodic memory loss, in the absence of detectable accelerated brain atrophy. Highlights: Identified cognitively unimpaired individuals in the emergent stage of Alzheimer's disease (AD). Emergent AD exhibits a greater rate of amyloid-β (Aβ) accumulation. No accelerated volume loss detected in the basal forebrain or hippocampus. Emergent AD is also associated with a subtle decline in memory. Early Aβ accumulation may impair cognitive function before structural atrophy.
Phytochemical Analysis And Antimicrobial Activity Of Micromeria Barbata Leaf And Stem Extracts Against Pseudomonas Aeruginosa: Insights From Molecular Docking And In Vitro Assays, Shiraz Rawas, Dalia El-Badan, Nawal Al Hakawati
Phytochemical Analysis And Antimicrobial Activity Of Micromeria Barbata Leaf And Stem Extracts Against Pseudomonas Aeruginosa: Insights From Molecular Docking And In Vitro Assays, Shiraz Rawas, Dalia El-Badan, Nawal Al Hakawati
BAU Journal - Science and Technology
The present study provides the characterization of the phytochemical content and the antibacterial activity of ethanolic extracts from the leaves (LM) and stems (SM) of Micromeria barbata (M.barbata) against Pseudomonas aeruginosa . Important functional groups were determined by analyzing the FTIR spectra of LM and SM. The phytochemical profiles were analyzed by GC-MS, and these characterized the chemicals according to retention periods and peak regions. The binding affinities of discovered compounds with the P. aeruginosa LasR and PqsD proteins were evaluated using molecular docking approach. Assays for biofilm formation, MIC, MBC, and agar well diffusion were used to assess the …
Vitamin D3 Toxicity-Induced Hypercalcemia In Staphylococcal Arthritis: A Focus On Il-6, Ali Jabbar Abd Al-Hussain Alkawaz, Maryam Sabah Naser, Ali Jalil Obaid, Zakaria M. Al-Ghazaly
Vitamin D3 Toxicity-Induced Hypercalcemia In Staphylococcal Arthritis: A Focus On Il-6, Ali Jabbar Abd Al-Hussain Alkawaz, Maryam Sabah Naser, Ali Jalil Obaid, Zakaria M. Al-Ghazaly
Karbala International Journal of Modern Science
Background: Vitamin D3 over-supplementation can induce toxicity through the development of hypercalcemia and may disturb immune modulation. This study examines the relationship between hypercalcemia resulting from Vitamin D3 Overdose and serum Interleukin-6 (IL-6) levels in patients diagnosed with staphylococcal arthritis.
Methods: Forty male patients (mean age: 31 years; range: 17–45 years) were enrolled from Dec. 2024 to Feb. 2025. Twenty cases of staphylococcal arthritis were compared with twenty healthy male controls. Serum concentrations of Vitamin D3, calcium, IL-6, and other biochemical markers (urea, creatinine, ESR, WBC, and potassium) were analyzed. Staphylococcus aureus was isolated from synovial fluid and confirmed using …
Chemical And Physical Characterization Of Verbenaceae Essential Oils Using Modern Analytical Methods And Chemometrics, Aleksandra N. Hilliard
Chemical And Physical Characterization Of Verbenaceae Essential Oils Using Modern Analytical Methods And Chemometrics, Aleksandra N. Hilliard
Master's Theses
Essential oils have been used for generations to treat various health issues, including mitigating insomnia, reducing stress, inflammation, and preserving foods, to mention a few. Essential oils have complex chemistry, which defines the essence of the host plant. Recently, increased commercial uses of essential oils have prompted attention at the governmental level to monitor the chemical, physical, or biological activity of essential oils. This study is an attempt to add new information for consumers to the understanding of the composition of essential oils.
Modern analytical techniques including FTIR-ATR, GC-MS, LC-MS-MS, multivariate analysis statistics, and physio-chemical techniques (electrochemistry, DPPH, TRC, and …
Pharmacogenetic-Guided Antiplatelet Therapy For Personalized Medicine In Patients With Stroke And Transient Ischemic Attack Without Cardioembolic Stroke: A Systematic Review Of Economic Evaluations, Nathapol Samprasit, Chamipa Phanudulkitti, Nattanichcha Kulthanachairojana, Jatapat Hemapanpairoa
Pharmacogenetic-Guided Antiplatelet Therapy For Personalized Medicine In Patients With Stroke And Transient Ischemic Attack Without Cardioembolic Stroke: A Systematic Review Of Economic Evaluations, Nathapol Samprasit, Chamipa Phanudulkitti, Nattanichcha Kulthanachairojana, Jatapat Hemapanpairoa
The Thai Journal of Pharmaceutical Sciences
Background: Stroke is a major global public health burden. Ischemic stroke is the most common type of all stroke cases worldwide. Antiplatelet therapy is a key strategy for secondary prevention in patients with stroke and transient ischemic attacks (TIAs) without cardioembolic stroke. Dual antiplatelet therapy (DAPT) with clopidogrel is recommended in patients with early mild stroke or high-risk TIA, followed by long-term single antiplatelet therapy (SAPT). Clopidogrel is often used as an alternative for patients with aspirin resistance or intolerance. However, clopidogrel is a prodrug metabolized by the CYP2C19 enzyme, leading to variability in its effectiveness.
Objectives: This study aims …
Deliberately Queer Journal Editors' Note For Volume One, Sean Te Maulding, Mel Monier
Deliberately Queer Journal Editors' Note For Volume One, Sean Te Maulding, Mel Monier
Deliberately Queer Journal
No abstract provided.
Ai-Based Classification Of Pediatric Breath Sounds: Toward A Tool For Early Respiratory Screening, Lichuan Liu, Wei Li, Beth Moxley
Ai-Based Classification Of Pediatric Breath Sounds: Toward A Tool For Early Respiratory Screening, Lichuan Liu, Wei Li, Beth Moxley
Faculty Scholarship-Nursing
Context: Respiratory morbidity is a leading cause of children’s consultations with general practitioners. Auscultation, the act of listening to breath sounds, is a crucial diagnostic method for respiratory system diseases. Problem: Parents and caregivers often lack the necessary knowledge and experience to identify subtle differences in children’s breath sounds. Furthermore, obtaining reliable feedback from young children about their physical condition is challenging. Methods: The use of a human–artificial intelligence (AI) tool is an essential component for screening and monitoring young children’s respiratory diseases. Using clinical data to design and validate the proposed approaches, we propose novel methods for recognizing and …
Synthesis Of Carboxymethyl Cellulose From Nypa Fruticans For Coating Metformin On Zn-Based Metal-Organic Framework Nanohybrid As A Bionanocomposite Drug Delivery System, Delviani Delviani, Viola Giary Rizkillah Maharani, Putri Nur Shadrina, Tri Warni, Regina Wan Azizah, Indra Lasmana Tarigan, Madyawati Latief
Synthesis Of Carboxymethyl Cellulose From Nypa Fruticans For Coating Metformin On Zn-Based Metal-Organic Framework Nanohybrid As A Bionanocomposite Drug Delivery System, Delviani Delviani, Viola Giary Rizkillah Maharani, Putri Nur Shadrina, Tri Warni, Regina Wan Azizah, Indra Lasmana Tarigan, Madyawati Latief
Makara Journal of Science
Diabetes is a common and rapidly spreading disease that affects 6.6% of the world’s population. Metformin hydrochloride (HCl) is an effective oral pharmacological treatment for type 2 diabetes mellitus (T2DM) patients because of its capability to reduce glucose levels and the risk of hypoglycaemia. However, gastrointestinal sensitivities to this drug can cause diarrhoea, nausea, vomiting and stomach ache. An alternative is controlled release technology by coating metformin with carboxymethyl cellulose (CMC) and zinc-metal-organic framework (Zn-MOF) through the encapsulation method. Therefore, this study aimed to coat metformin formulations using CMC in a Zn-MOF to control release into the body and minimise …
Alternate Form Reliability Of Nine Possible Four-Subtest Combinations Of The Cognitive Proficiency Index For The Wechsler Adult Intelligence Scale-Iv (Wais-Iv) In A Clinical Sample, Joseph J. Ryan, David S. Kreiner, Charles Golden, Gordon Teichner, Samuel T. Gontkovsky
Alternate Form Reliability Of Nine Possible Four-Subtest Combinations Of The Cognitive Proficiency Index For The Wechsler Adult Intelligence Scale-Iv (Wais-Iv) In A Clinical Sample, Joseph J. Ryan, David S. Kreiner, Charles Golden, Gordon Teichner, Samuel T. Gontkovsky
Archives of Assessment Psychology
Performance on the core working memory (Digit Span + Arithmetic) and processing speed (Coding + Symbol Search) subtests of the WAIS-IV is summarized by the Cognitive Proficiency Index (CPI). If a working memory subtest is spoiled, Letter-Number Sequencing is substituted. An invalidated processing speed subtest is replaced by Cancellation. These tasks are supplementary. The core and supplementary subtests yield nine four-subtest composites. Using the standardization sample, Campbell, Rossini, and Johnson (2022) demonstrated that all CPI tetrads had excellent alternate form reliability. In the present study, a clinical sample (n = 90) produced equally high reliabilities. Four of the new …
The Only Constant Is Change: The Role Of Genetic Diversification In Cancer And Beyond, Malgorzata Tyczynska Weh
The Only Constant Is Change: The Role Of Genetic Diversification In Cancer And Beyond, Malgorzata Tyczynska Weh
USF Tampa Graduate Theses and Dissertations
Genetic diversification, the process by which genetic variation arises in a population, is fundamental to evolution by natural selection. Mutation, a central diversification process, fuels adaptation across species, including in cancer. Yet most new mutations are neutral or deleterious on cell fitness, raising the question of how mutation-driven adaptation persists. To explore this paradox, I developed a spatial agent-based model (ABM) in which population fitness emerges from individual cells acquiring mutations at varied rates and with diverse fitness effects. I evaluated model behavior across adaptive states, mutation rates, and distributions of fitness effects. The results show that high mutation rates …
Hypertensive Disorders Of Pregnancy And Perinatal Outcomes: Two Prospective Cohort Studies Of Nulliparous Women In India And Tanzania, Andrea B. Pembe, Pratibha Dwarkanath, Amani Kikula, John Michael Raj, Nandita Perumal Phd, Heavenlight A. Paulo, Rajalakshmi M, Christopher P. Duggan, Honorati M. Masanja, Nandini Chopra, Mary M. Sando, Tinku Thomas, Cara A. Yelverton, Alfa Muhihi, Anura V. Kurpad, Wafaie E. Fawzi, Blair J. Wylie, Christopher R. Sudfeld
Hypertensive Disorders Of Pregnancy And Perinatal Outcomes: Two Prospective Cohort Studies Of Nulliparous Women In India And Tanzania, Andrea B. Pembe, Pratibha Dwarkanath, Amani Kikula, John Michael Raj, Nandita Perumal Phd, Heavenlight A. Paulo, Rajalakshmi M, Christopher P. Duggan, Honorati M. Masanja, Nandini Chopra, Mary M. Sando, Tinku Thomas, Cara A. Yelverton, Alfa Muhihi, Anura V. Kurpad, Wafaie E. Fawzi, Blair J. Wylie, Christopher R. Sudfeld
Faculty Publications
Introduction Hypertensive disorders of pregnancy (HDP) have been linked with increased risk for maternal and offspring complications in high-income settings. However, in resource-limited settings, studies with robust measurement of HDP, including severity and timing, and perinatal outcomes are limited.
Methods We analysed data from two prospective cohorts of nulliparous women in India (n=10 570 pregnancies) and Tanzania (n=10 299 pregnancies) who were enrolled in calcium supplementation trials and had blood pressure and proteinuria assessments throughout pregnancy and at the time of labour and delivery. Generalised estimating equations were used to assess the relationship between HDP severity categories (gestational hypertension, preeclampsia …
Effect Of The Cervical Lesion Severity On Procedural And Clinical Outcomes After Endovascular Treatment Of Acute Tandem Lesions: A Multicenter Study, Milagros Galecio-Castillo, Mudassir Farooqui, Ameer E. Hassan, Mouhammad A. Jumaa, Afshin A. Divani, Marc Ribo
Effect Of The Cervical Lesion Severity On Procedural And Clinical Outcomes After Endovascular Treatment Of Acute Tandem Lesions: A Multicenter Study, Milagros Galecio-Castillo, Mudassir Farooqui, Ameer E. Hassan, Mouhammad A. Jumaa, Afshin A. Divani, Marc Ribo
School of Medicine Publications
Background
Tandem lesions pose unique challenges in the endovascular treatment of acute ischemic stroke. We aimed to compare the clinical and procedural outcomes of patients with tandem lesions and extracranial internal carotid artery (ICA) complete occlusion versus those with moderate to severe stenosis.
Methods
This is a subanalysis of a multicenter cohort of patients with acute anterior circulation tandem lesions treated with intracranial mechanical thrombectomy and carotid artery stenting, between January 2015 and December 2020. The patients were categorized into 2 groups: extracranial ICA stenosis >70% to 99% and complete occlusion. Outcomes included successful and excellent recanalization, functional independence, symptomatic …
Multiscale Modeling Of Drug-Induced Liver Injury From Organ To Lobule, Alon Malka-Markovitz, Stelian Camara Dit Pinto, Mohammed Cherkaoui, Steven M Levine, Sharmila Anandasabapathy, Gagan K Sood, Sadhna Dhingra, Gao Yujia, John M Vierling, Nicolas R Gallo
Multiscale Modeling Of Drug-Induced Liver Injury From Organ To Lobule, Alon Malka-Markovitz, Stelian Camara Dit Pinto, Mohammed Cherkaoui, Steven M Levine, Sharmila Anandasabapathy, Gagan K Sood, Sadhna Dhingra, Gao Yujia, John M Vierling, Nicolas R Gallo
Center for Medical Ethics and Health Policy Staff Publications
Drug-induced liver injury poses significant challenges in drug development and in clinical care. This study builds on prior work developing a Human Liver Virtual Twin by creating a Multiscale Computational Fluid Dynamics framework that integrates patient-specific anatomical data to predict acetaminophen-induced liver injury as a demonstration of its capability. The model bridges vascular, lobular, and cellular scales to simulate dynamic blood flow, drug transport, and injury mechanisms that accurately reflect clinically observed spatial heterogeneity. Results demonstrate accurate blood flow dynamics, predictions of hepatocellular damage, and a scalable framework for studying spatial heterogeneity applicable to other hepatic pathologies. This work establishes …
Agenda (Pdf), Department Of Orthopaedic Surgery
Agenda (Pdf), Department Of Orthopaedic Surgery
Dept. of Orthopaedics: Robert D. D’Ambrosia Lectureship & Research Day
No abstract provided.
Investigation Of The Relationship Between Triglyceride Glucose Index And Metabolic And Hematological Parameters In Obese Individuals, Özge Baş Aksu, Feri̇de Özkara, Rifat Emral, Volkan Genç, Demet Çorapçioğlu, Mustafa Şahi̇n
Investigation Of The Relationship Between Triglyceride Glucose Index And Metabolic And Hematological Parameters In Obese Individuals, Özge Baş Aksu, Feri̇de Özkara, Rifat Emral, Volkan Genç, Demet Çorapçioğlu, Mustafa Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: This research examined the association between the triglyceride-glucose (TyG) index and metabolic, hepatic, and hematologic variables in a population of severely obese subjects, with a focus on the assessment of glycemic control.
Materials and methods: This retrospective study included 315 adult patients with a body mass index (BMI) ≥ 35 kg/m² who were evaluated for bariatric surgery. Participants were grouped according to HbA1c levels: those with HbA1c ≥ 6.5% and those with HbA1c < 6.5%. TyG, atherogenic index of plasma (AIP), fibrosis-4 (FIB-4), aspartate aminotransferase-to-platelet ratio index (APRI), and hematological inflammation markers were assessed and compared between groups. To investigate associations, correlation and regression analyses were conducted.
Results: Individuals with HbA1c ≥ 6.5% had significantly higher TyG, AIP, APRI, and FIB-4 values than those with lower HbA1c. The TyG index showed a strong …
Phosphatase-Substrate Prediction Using Heterogeneous Knowledge Graph, Jannatul Ferdaus, Marzieh Ayati, Hansapani Rodrigo
Phosphatase-Substrate Prediction Using Heterogeneous Knowledge Graph, Jannatul Ferdaus, Marzieh Ayati, Hansapani Rodrigo
Research Symposium
Background: Phosphatase-substrate interactions may serve as biomarkers for diseases, offering crucial insights to support early diagnosis. Analyzing these substrate-specific interactions is also crucial in recommending different drugs. In our research, we constructed a knowledge graph that provides a comprehensive network representation, capturing diverse relationships among biological entities relevant to phosphatases.
Methods: Our knowledge graph represents 5 unique nodes- kinase, phosphatase, substrate, drug, and disease. The connections between the nodes are obtained from DrugMap (drug and their target proteins; disease and their associated proteins), STRING protein-protein interaction, DEPOD 2019 (phosphatase and their substrate), PhosphoSitePLUS (kinases and their substrate), and UniProt. As …
Association Between Dietary Inflammatory And Antioxidant Potential And Systemic Inflammatory And Oxidative Status With The Risk And Severity Of Coronary Artery Disease, Zahara Namkhah, Elham Alipoor, Manhnaz Salmani, Negar Ebrahimi, Monireh Ahmadpanahi, Ali Vasheghani-Farahani, Mehdi Yaseri, Michael David Wirth, Longgang Zhao, James Hébert Scd, Javad Hosseinzadeh-Attar
Association Between Dietary Inflammatory And Antioxidant Potential And Systemic Inflammatory And Oxidative Status With The Risk And Severity Of Coronary Artery Disease, Zahara Namkhah, Elham Alipoor, Manhnaz Salmani, Negar Ebrahimi, Monireh Ahmadpanahi, Ali Vasheghani-Farahani, Mehdi Yaseri, Michael David Wirth, Longgang Zhao, James Hébert Scd, Javad Hosseinzadeh-Attar
Faculty Publications
Background and aims
Unhealthy diets have pro-inflammatory properties that have been shown to contribute to coronary artery disease (CAD). The dietary inflammatory index (DII®) and the dietary antioxidant quality score (DAQS) quantify the anti-/pro-inflammatory and antioxidant potential of a diet. This study aims to investigate the association between the energy-adjusted DII (E-DIITM), DAQS, oxidant/anti-oxidant biomarkers, and CAD risk and severity.
Methods and results
This cross-sectional study investigated 158 participants for the presence and severity of CAD based on coronary angiography. E-DII and DAQS scores, malondialdehyde (MDA), total oxidant status (TOS), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC) and conventional …
A Community-Based Study To Investigate Persistent Ambient Odors In Childs Park, Fl, Gennaro Saliceto
A Community-Based Study To Investigate Persistent Ambient Odors In Childs Park, Fl, Gennaro Saliceto
USF Tampa Graduate Theses and Dissertations
For many years, residents in Childs Park, Saint Petersburg, Florida, have reported unpleasant odors. Although there have been prior efforts to address the issue, the odors continue to be a concern for the community, who worry about possible health implications. This research aimed to equip residents with information to address the issue by identifying the presence of airborne pollutants that generate odors, quantifying the concentrations of toxic organic pollutants, and exploring the sources and environmental conditions that contribute to odors and their perception.
To accomplish these aims, the study utilized different methods. First, two walking measurement campaigns were conducted to …
Psycho-Analysis Will Not Save Us: Reflections On The Gen Z Mental Health Crisis, Victor Dubitans
Psycho-Analysis Will Not Save Us: Reflections On The Gen Z Mental Health Crisis, Victor Dubitans
Middle Voices
Generation Z (born between 1997 – 2012) is characterized as having both unprecedented mental health awareness and unprecedented mental distress. An apparent contradiction with troubling implications for the mental health field: Either the response to the mounting crisis has been insufficient or the field forms part of the problem. Taking seriously Wilks’ (2023) criticism of “therapeutic overreach” of the contemporary mental health field in the lives and development of youth, this paper attempts a selfanalysis and moral inventory about the field’s potential complicity in the crisis and in the history of hysteria. Lacan’s writings on the “analyst’s discourse” are considered …
Proceedings Of The Cuny Games Conference 11.0, Robert O. Duncan, Grace Axler-Diperte, Joe Bisz, Christina Boyle, Devorah Kletenik, Carolyn Stallard
Proceedings Of The Cuny Games Conference 11.0, Robert O. Duncan, Grace Axler-Diperte, Joe Bisz, Christina Boyle, Devorah Kletenik, Carolyn Stallard
Publications and Research
The CUNY Games Conference combines workshops, idea exchanges, interactive participant presentations, playtesting, and playing tabletop games into a one-day online event to promote and discuss game-based learning. The conference focuses on creative pedagogy, such as playful learning activities or games, that teachers can use in the classroom every day. The conference is online and features interactive presentations by attendees, informal idea exchange sessions, and workshops by the conference organizers.
Carbon Monoxide Releasing Polymeric Micelles, Riya Joshi
Carbon Monoxide Releasing Polymeric Micelles, Riya Joshi
Electronic Theses and Dissertations
Carbon monoxide (CO), traditionally known as a toxic gas, has emerged as a potential therapeutic agent due to its cytoprotective, anti-inflammatory, and vasodilatory properties. This study explores the development of CO-releasing polymeric micelles as a controlled delivery system for biomedical applications. Using ring-opening metathesis polymerization (ROMP), we synthesized diblock copolymers incorporating CO-releasing moiety diphenylcyclopropenone (DPCP) with hydrophilic polyethylene glycol (PEG) to enhance solubility and stability of the overall CO releasing system. Dynamic light scattering (DLS) and electron microscopy (EM) confirmed the formation of well-defined micelles, while fluorescence assays demonstrated efficient CO release with the use of Iridium photocatalyst under 470 …
Early Diagnosis And Detection Of Skin Cancer Using Deep Neural Network Models And Feature Extraction From Pre-Trained Cnns, Sahil Khanna
Early Diagnosis And Detection Of Skin Cancer Using Deep Neural Network Models And Feature Extraction From Pre-Trained Cnns, Sahil Khanna
Harrisburg University Dissertations and Theses
Skin cancer is one of the most common and lethal cancer types. While accurate diagnosis at an early stage is essential for skin cancer treatment it remains difficult to achieve in many regions due to lack of sufficient dermatologists and proper diagnostic equipment. Prior studies show Convolutional Neural Network (CNN) models excel at skin lesion classification and consistently achieve better results than standard diagnostic practices. However, the focus of many studies remains confined to image-based learning while neglecting useful patient metadata that could improve prediction accuracy. This research project created a specialized CNN model to classify skin lesions and evaluated …
Implementation And Evaluation Of A Weight Management Programme For Overweight Or Obese Pregnant Women: A Randomised Controlled Trial, Elahe Banafshe, Nahid Javadifar, Zahra Abbaspoor, Saeed Ghanbari, Majid Karandish
Implementation And Evaluation Of A Weight Management Programme For Overweight Or Obese Pregnant Women: A Randomised Controlled Trial, Elahe Banafshe, Nahid Javadifar, Zahra Abbaspoor, Saeed Ghanbari, Majid Karandish
Sultan Qaboos University Medical Journal
Objectives: Obesity is a major health concern, particularly among women of reproductive age. This study aimed to evaluate the effectiveness of a psychosocial-based intervention on weight management and pregnancy outcomes in overweight or obese pregnant women. Methods: This randomised controlled trial included overweight or obese pregnant women from healthcare centres affiliated with Jundishapur University of Medical Sciences in Ahvaz, Iran and was conducted from June to December 2023. Participants were randomly assigned to an intervention or control group. The intervention group received a comprehensive weight management programme during pregnancy, while the control group received standard prenatal care. Results …
Mapping Vascular Network Architecture In Primate Brain Using Ferumoxytol-Weighted Laminar Mri, Joonas A Autio, Ikko Kimura, Takayuki Ose, Yuki Matsumoto, Masahiro Ohno, Yuta Urushibata, Takuro Ikeda, Matthew F Glasser, David C Van Essen, Takuya Hayashi
Mapping Vascular Network Architecture In Primate Brain Using Ferumoxytol-Weighted Laminar Mri, Joonas A Autio, Ikko Kimura, Takayuki Ose, Yuki Matsumoto, Masahiro Ohno, Yuta Urushibata, Takuro Ikeda, Matthew F Glasser, David C Van Essen, Takuya Hayashi
2020-Current year OA Pubs
Mapping the vascular organization of the brain is of great importance across various domains of basic neuroimaging research, diagnostic radiology, and neurology. However, the intricate task of precisely mapping vasculature across brain regions and cortical layers presents formidable challenges, resulting in a limited understanding of neurometabolic factors influencing the brain's microvasculature. Addressing this gap, our study investigates whole-brain vascular volume using ferumoxytol-weighted laminar-resolution multi-echo gradient-echo imaging in macaque monkeys. We validate the results with published data for vascular densities and compare them with cytoarchitecture, neuron and synaptic densities. The ferumoxytol-induced change in transverse relaxation rate (ΔR
Insights Into The Floral Senescence Effects Of Nanoparticles, Vuk Uskoković
Insights Into The Floral Senescence Effects Of Nanoparticles, Vuk Uskoković
Administration and Staff Articles and Research
Flowers could be valuable addenda to nanomedicine labs as in vivo models crossing the gap between the cell culture and small mammals. However, as it is shown here, floral models continue to be predominantly utilized within resource-limited research environments and remain largely underrepresented in mainstream biomedical investigations conducted by well-funded institutions in the developed world. The ability to delay the senescence of Orange Jubilee wildflowers was tested here on three types of nanoparticles: selenite-doped hydroxyapatite (HAp), citrate-stabilized HAp, and superparamagnetic iron oxide. Integration of selenite into the HAp crystal lattice produced a mild increase in the senescence rate …
Temporal Modeling And Forecasting Of Blood Glucose Dynamics In Individuals With Diabetes Mellitus, Mj Ruff
Temporal Modeling And Forecasting Of Blood Glucose Dynamics In Individuals With Diabetes Mellitus, Mj Ruff
University Honors Theses
People living with Diabetes Mellitus face significant health risks, including an increased likelihood of heart disease, stroke, and fluctuations in blood glucose levels. The unpredictable nature of glucose levels can lead to dangerous conditions such as ketoacidosis and hypoglycemia. This study employs advanced time series analysis tools to forecast the glucose levels for an individual diagnosed with Type 1 Diabetes Mellitus.
Forecasting Influenza Rates Using Machine Learning: A Study Of Chatgpt's Predictive Accuracy, Sara Saleh
Forecasting Influenza Rates Using Machine Learning: A Study Of Chatgpt's Predictive Accuracy, Sara Saleh
University Honors Theses
This study evaluates ChatGPT's ability to forecast influenza rates, such as the number of flu cases, hospitalizations, and death during peak season periods using CDC data, and comparing forecasts against actual results to calculate statistical accuracy and consistency. Influenza forecasting is essential for public health planning, but traditional methods may not always provide timely or accurate predictions. In this research study, ChatGPT was utilized to predict the influenza rates for the following week based on the previous week's data obtained from the FluView surveillance system. The predicted rates were compared to the actual influenza rates to assess the model's overall …
Ensemble-Based Binding Free Energy Profiling And Network Analysis Of The Kras Interactions With Darpin Proteins Targeting Distinct Binding Sites: Revealing Molecular Determinants And Universal Architecture Of Regulatory Hotspots And Allosteric Binding, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker
Ensemble-Based Binding Free Energy Profiling And Network Analysis Of The Kras Interactions With Darpin Proteins Targeting Distinct Binding Sites: Revealing Molecular Determinants And Universal Architecture Of Regulatory Hotspots And Allosteric Binding, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker
Mathematics, Physics, and Computer Science Faculty Articles and Research
KRAS is a pivotal oncoprotein that regulates cell proliferation and survival through interactions with downstream effectors such as RAF1. Despite significant advances in understanding KRAS biology, the structural and dynamic mechanisms of KRAS allostery remain poorly understood. In this study, we employ microsecond molecular dynamics simulations, mutational scanning, and binding free energy calculations together with dynamic network modeling to dissect how engineered DARPin proteins K27, K55, K13, and K19 engage KRAS through diverse molecular mechanisms ranging from effector mimicry to conformational restriction and allosteric modulation. Mutational scanning across all four DARPin systems identifies a core set of evolutionarily constrained residues …
The Relationship Between Food Label Comprehension And Consumer Dietary Choices, Marline Denis
The Relationship Between Food Label Comprehension And Consumer Dietary Choices, Marline Denis
Walden Dissertations and Doctoral Studies
Poor dietary choices and limited understanding of nutritional information are ongoing public health concerns that contribute to the rise of chronic illnesses such as obesity, diabetes, and heart disease. This quantitative, cross-sectional, correlational study investigated the associations between health literacy and food label comprehension with consumer dietary choices and adherence to dietary guidelines among individuals aged 16 and older in the United States. Guided by the Nutrition Label Literacy (NLL) framework, this study explored whether components such as basic nutritional knowledge, numeracy skills, health motivation, and label usage predict healthier food choices. Age, education, and gender were included as covariates. …
Current Practice In The Provision Of Psychological Assessment, Catherine R. Hanigan, Linda J. Baum, Anderson B. Rowan
Current Practice In The Provision Of Psychological Assessment, Catherine R. Hanigan, Linda J. Baum, Anderson B. Rowan
Archives of Assessment Psychology
Understanding the assessment practices of psychologists has been a focus of research since the mid-twentieth century. Previous studies focused on the types of tests utilized as well as the amount of time spent on assessment. This updated research examined professional psychologists’ current practice and use of assessment, such as specific test usage, time spent on assessment, and feedback practices. A survey instrument was created, piloted, and administered to a sample of 293 currently practicing licensed psychologists. Results indicated that current assessment practices are largely consistent with previous surveys of psychologists. The tests identified as most frequently used were the Wechsler …