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Articles 61 - 90 of 167620
Full-Text Articles in Entire DC Network
Living Next Door To Mcdonald’S: A Qualitative Study Of Community Submissions And Resident Realities Pre- And Post Development, Roslyn Giglia, Jacinta Francis, Jana Buckle, Clare Whitton, Ros Sambell, Frith Klug, Lukar Thornton, Siobhan Hickling, Katherine Kent, Gina Trapp
Living Next Door To Mcdonald’S: A Qualitative Study Of Community Submissions And Resident Realities Pre- And Post Development, Roslyn Giglia, Jacinta Francis, Jana Buckle, Clare Whitton, Ros Sambell, Frith Klug, Lukar Thornton, Siobhan Hickling, Katherine Kent, Gina Trapp
Research outputs 2022 to 2026
Background: The proliferation of fast-food outlets (FFOs) in residential areas has raised growing concerns about their impact on community health, safety, and wellbeing. This qualitative study examined both pre-development community consultation submissions and post-development resident experiences surrounding the development of a McDonald’s outlet in a newly established suburb on the urban fringe of Perth, Western Australia (WA). Methods: Using a qualitative descriptive design, the study analyzed 183 community submissions lodged with the local council prior to development and conducted semi-structured interviews with 11 residents living within 300 m of the outlet after construction. Results: Content analysis revealed strong opposition, with …
Lessons Learned From A Randomised Controlled Trial Of A Digital Intervention Targeting Eating Disorder Symptoms In Cisgender Sexual Minoritized Men, Emma Austen, Matthew Fuller-Tyszkiewicz, Siân A. Mclean, Beth O’Gorman, Katie Bishop, Hannah K. Jarman, Susan J. Paxton, Rachel F. Rodgers, An Dang, Emily A. Harris, Felicity Angelopoulos, Wesley Grey, Suku Sukunesan, Alexandra Parker, Adrian Shatte, Long Khanh-Dao Le, Scott Griffiths
Lessons Learned From A Randomised Controlled Trial Of A Digital Intervention Targeting Eating Disorder Symptoms In Cisgender Sexual Minoritized Men, Emma Austen, Matthew Fuller-Tyszkiewicz, Siân A. Mclean, Beth O’Gorman, Katie Bishop, Hannah K. Jarman, Susan J. Paxton, Rachel F. Rodgers, An Dang, Emily A. Harris, Felicity Angelopoulos, Wesley Grey, Suku Sukunesan, Alexandra Parker, Adrian Shatte, Long Khanh-Dao Le, Scott Griffiths
Research outputs 2022 to 2026
Background: There is an unmet need for evidence-based and accessible interventions designed to treat eating disorders in sexual minoritized men, given their heightened vulnerability to developing disordered eating. Digital interventions are a promising avenue for eating disorder treatment because of their accessibility and flexibility in delivery. Here, we present a randomised controlled trial of Seed, a 10-week treatment-focussed digital intervention for eating disorders, among sexual minoritized men.
Methods: Participants (N = 126 sexual minoritized men) with a binge-spectrum eating disorder diagnosis (e.g., bulimia nervosa, binge-eating disorder) were randomly allocated to one of three conditions: (1) a waitlist control (2) a …
Transcutaneous Auricular Vagus Nerve Stimulation Paired With Task-Specific Training For Improving Walking And Balance In Chronic Stroke: A Double-Blind, Randomised Controlled Feasibility Trial, Ashraf N.H. Gerges, Jeric Uy, Lewis Ingram, Susan Hillier, Joanne Bouckley, Ellana Welsby, Ines Serrada, Taya Hamilton, Saran Chamberlain, Brenton Hordacre
Transcutaneous Auricular Vagus Nerve Stimulation Paired With Task-Specific Training For Improving Walking And Balance In Chronic Stroke: A Double-Blind, Randomised Controlled Feasibility Trial, Ashraf N.H. Gerges, Jeric Uy, Lewis Ingram, Susan Hillier, Joanne Bouckley, Ellana Welsby, Ines Serrada, Taya Hamilton, Saran Chamberlain, Brenton Hordacre
Research outputs 2022 to 2026
Background: Transcutaneous auricular vagus nerve stimulation (taVNS) paired with task-specific training has shown promise for improving upper-limb motor recovery after stroke but its effects on gait and balance remain unclear. This study evaluated the feasibility and safety of taVNS paired with task-specific training and explored preliminary effects on walking and balance outcomes in adults with chronic stroke.
Methods: A double-blinded, sham-controlled trial was conducted to evaluate active versus sham taVNS paired with task-specific training (15 one-hour sessions over six weeks). Feasibility metrics included recruitment, participant experience, adverse events (AEs), and blinding effectiveness. Clinical outcomes (walking speed, endurance, gait parameters, and …
A Dynamic Framework Of Professional Identity Formation In Trainees For Low-Resource Settings: A Qualitative Study, Yilin Chen, Peixin Lin, Hengshun Du, Jiaxin Wu, Xuanhua Zheng, Mi Yao, Kai Lin
A Dynamic Framework Of Professional Identity Formation In Trainees For Low-Resource Settings: A Qualitative Study, Yilin Chen, Peixin Lin, Hengshun Du, Jiaxin Wu, Xuanhua Zheng, Mi Yao, Kai Lin
Research outputs 2022 to 2026
Background: Professional Identity Formation (PIF) is a dynamic and context-dependent socialisation process; while existing research identifies various influencing factors, there is a paucity of cohesive frameworks that capture the stage-related internalisation of identity elements within practice. This gap is particularly salient in low-resource settings, such as China’s Rural-Streamed Medical Education Programme (RMEP), where substantial turnover and tenuous professional identity among trainees present significant challenges. Drawing upon the Ring Theory of Personhood (RToP) as a theoretical lens, this study aims to construct a dynamic framework for understanding PIF among RMEP trainees, thereby offering insights to enhance PIF for healthcare professionals in …
The Impact Of Testing-Parameter Variability On Force Production In The Isometric Single-Leg Long-Lever Bridge: Implications For Training And Testing Rigor In Sporting Environments, Adam E. Sundh, Nicholas J. Ripley, A. J. Lamb, Conor J. Cantwell, Paul Comfort
The Impact Of Testing-Parameter Variability On Force Production In The Isometric Single-Leg Long-Lever Bridge: Implications For Training And Testing Rigor In Sporting Environments, Adam E. Sundh, Nicholas J. Ripley, A. J. Lamb, Conor J. Cantwell, Paul Comfort
Research outputs 2022 to 2026
Background: The aim of this study was to determine the impact of knee angle variability on force production outcomes during the single-leg isometric long-lever bridge, thus providing monitoring guidelines for testing rigor with direct implications for feasibility across a variety of high-performance sporting environments. Methods: Thirty men (age: 19.4 ± 1.3 years; height: 179.8 ± 6.3 cm; body mass: 80.4 ± 10.3 kg) and 14 women (age: 20.0 ± 1.3 years; height: 166.9 ± 7.2 cm; body mass: 64.4 ± 7.4 kg) all of whom were Division 3 athletes with no recent injury history volunteered to participate in the study. …
Temptation At The School Fence: A Qualitative Exploration Of The Impact Of External Food Outlets On The School Community, Sharonna Mossenson, Klug, Jacinta Francis, Siobhan Hickling, Lukar Thornton, Gina Trapp
Temptation At The School Fence: A Qualitative Exploration Of The Impact Of External Food Outlets On The School Community, Sharonna Mossenson, Klug, Jacinta Francis, Siobhan Hickling, Lukar Thornton, Gina Trapp
Research outputs 2022 to 2026
Retail food outlets are commonly located in close proximity to schools, providing students with opportunities to purchase and consume food enroute to or from school. These outlets are typically unhealthy and disproportionately clustered near schools, and this trend has been increasing over time. While quantitative studies have established associations between school food environments and adolescent dietary behaviours, little is known about how school personnel perceive and experience their impacts. This qualitative study explored perspectives of school personnel (n = 9) from a secondary school in Perth, Western Australia, located 150 m from two retail food precincts (areas with a high …
The Effect Of School-Based Educational Session On Knowledge, Attitudes, And Beliefs Of Cervical Cancer Among Adolescents In Mixed Day High Schools In Embu County: A Quasi-Experimental Study, Lucy W. Kivuti-Bitok, Mugo, Dorothy Mituki, Christine Marete, Irene Ngune, Jessica Wells
The Effect Of School-Based Educational Session On Knowledge, Attitudes, And Beliefs Of Cervical Cancer Among Adolescents In Mixed Day High Schools In Embu County: A Quasi-Experimental Study, Lucy W. Kivuti-Bitok, Mugo, Dorothy Mituki, Christine Marete, Irene Ngune, Jessica Wells
Research outputs 2022 to 2026
Background: School-based interventions have proven effective in enhancing knowledge and altering attitudes toward cervical cancer among adolescents. This study aimed to evaluate the effect of a school-based educational intervention on the attitudes, beliefs, and knowledge of cervical cancer among adolescents in mixed-day high schools in Embu County. Methods: This study used a single-group, repeated cross-sectional design to assess the effect of a structured health education session on cervical cancer among adolescent boys and girls in mixed-gender secondary schools. A self-administered anonymous questionnaire was administered before and immediately after the post-intervention. The education session lasted 30–45 min, and the study population …
Acute Effects Of Accentuated Eccentric Loading On Mean Concentric Velocity During Resistance Training: A Systematic Review And Meta-Analysis, Jiahao Yang, Tsuyoshi Nagatani, Paul Comfort, Kristina L. Kendall, G. Gregory Haff
Acute Effects Of Accentuated Eccentric Loading On Mean Concentric Velocity During Resistance Training: A Systematic Review And Meta-Analysis, Jiahao Yang, Tsuyoshi Nagatani, Paul Comfort, Kristina L. Kendall, G. Gregory Haff
Research outputs 2022 to 2026
Background: Accentuated eccentric loading (AEL) may acutely enhance the concentric (CON) barbell velocity after the additional eccentric (ECC) load is removed, however there are inconsistent results regarding the effectiveness of this practice within the scientific literature. Objective: The aims of the present study were to: (1) examine the acute effects of applying AEL, only on the first repetition of a set, on mean barbell velocity during the CON phase of the first 3 repetitions of the set and (2) investigate the influence of the magnitude of ECC load, loading differential and exercise selection on the acute effects of AEL. Methods: …
Progression Of Non-Radiographic To Radiographic Axial Spondyloarthritis: A Risk Model Based On A Chinese Cohort Study, Rui Ying Deng, Xiaojia Xu, Jian Hua Peng, Feng Cai Shen, Yao Gong, Dan Min Wang, Hong Jin Liang, Shu Xin Huang, Zhao Peng Chen, Wen Long Wu, Ze Xin Zheng, Ling Lin, Zhi Duo Hou
Progression Of Non-Radiographic To Radiographic Axial Spondyloarthritis: A Risk Model Based On A Chinese Cohort Study, Rui Ying Deng, Xiaojia Xu, Jian Hua Peng, Feng Cai Shen, Yao Gong, Dan Min Wang, Hong Jin Liang, Shu Xin Huang, Zhao Peng Chen, Wen Long Wu, Ze Xin Zheng, Ling Lin, Zhi Duo Hou
Research outputs 2022 to 2026
Objectives: To evaluate the progression from non-radiographic axial spondyloarthritis (nr-axSpA) to radiographic axial spondyloarthritis (r-axSpA) in a Chinese cohort, identify associated risk factors in both clinical and imaging arms, and enable risk stratification based on these factors. Methods: Overall, 572 patients with nr-axSpA were enrolled with a median follow-up of 5 years. Cox proportional hazard regression analyses were conducted to identify potential risk factors associated with the progression from nr-axSpA to r-axSpA in both clinical and imaging arms. A risk-scoring system was then developed by assigning each independent predictor a weight based on its regression coefficient. Patients were subsequently categorized …
Genetic Drivers Of Progression In Alzheimer’S Disease Are Distinct From Disease Risk, Celeste E. Cohen, Shane Fernandez, Umran Yaman, Ahmad R. Ehyaei, Eleftheria Kodosaki, Aydan Askarova, Tenielle Porter, Eleanor O’Brien, Paul Maruff, Alexi Nott, John A. Hardy, Simon M. Laws, Dervis A. Salih, Maryam Shoai
Genetic Drivers Of Progression In Alzheimer’S Disease Are Distinct From Disease Risk, Celeste E. Cohen, Shane Fernandez, Umran Yaman, Ahmad R. Ehyaei, Eleftheria Kodosaki, Aydan Askarova, Tenielle Porter, Eleanor O’Brien, Paul Maruff, Alexi Nott, John A. Hardy, Simon M. Laws, Dervis A. Salih, Maryam Shoai
Research outputs 2022 to 2026
Background: Recent trials in Alzheimer’s disease (AD) demonstrate encouraging outcomes. These trials target risk mechanisms identified through genetic analysis whilst directly aiming to reduce progression rates. Evidence from other neurodegenerative diseases suggests the genetics of progression is distinct from risk of disease. To expand these initial successes and improve clinical outcomes further we need to understand genetics of progression of disease. These can be deduced through rigorous analysis of meticulously phenotyped longitudinal cohorts. In this study we first looked at known genetic drivers of risk, namely polygenic risk scores for AD and APOE‑ε4, to assess their role in progression. This …
Local Government Policies Restricting Unhealthy Outdoor Food Advertising In Australia: Stakeholder Perspectives Identify Political Willingness Is Key To Overcoming Barriers, Alexia Bivoltsis, Frith Klug, Jacinta Francis, Clare Whitton, Gina S.A. Trapp, Claire E. Pulker
Local Government Policies Restricting Unhealthy Outdoor Food Advertising In Australia: Stakeholder Perspectives Identify Political Willingness Is Key To Overcoming Barriers, Alexia Bivoltsis, Frith Klug, Jacinta Francis, Clare Whitton, Gina S.A. Trapp, Claire E. Pulker
Research outputs 2022 to 2026
Background: Unhealthy outdoor food advertising is strongly linked to poor diet, highlighting the need for policies. Western Australian (WA) local governments (LGs) can restrict advertising on their owned infrastructure through their Public Health Plans, but limited policy action has occurred. This study aimed to explore the perspectives of WA LGs and public health organizations (PHOs) on current and potential policies restricting unhealthy outdoor food advertising on LG owned infrastructure to (1) identify barriers and enablers to the policy making process, (2) assess the current level of political willingness (i.e. political want, political can and political must) and (3) inform development …
Perspective: Improving Social Connection And Inclusion Through Equitable Digital Health Solutions, Dominika Kwasnicka, Jaimon Kelly, Eleanor Quested, Loretta Baldassar, Suzanne Robinson, Richard Sinnott, Paul O’Halloran, Anne Tiedemann, Paul Flatau, Rajna Ogrin, Jane Farmer, Abby C. King
Perspective: Improving Social Connection And Inclusion Through Equitable Digital Health Solutions, Dominika Kwasnicka, Jaimon Kelly, Eleanor Quested, Loretta Baldassar, Suzanne Robinson, Richard Sinnott, Paul O’Halloran, Anne Tiedemann, Paul Flatau, Rajna Ogrin, Jane Farmer, Abby C. King
Research outputs 2022 to 2026
In this Perspective, we address the critical intersection of digital health, social connection, and health equity. Taking an interdisciplinary and complex adaptive systems perspective, we highlight evidence-based digital solutions to improve social connection and inclusion and, consequently, health outcomes. We describe actionable strategies for ensuring that digital health innovations benefit all, highlighting how user-centered design can address diverse needs, particularly for structurally disadvantaged populations.
Free-Fall Normalised Peak Braking Velocity For Countermovement Jump Monitoring, Karol Kruczek, André Rebelo, Jason Lake, Michał Nowak
Free-Fall Normalised Peak Braking Velocity For Countermovement Jump Monitoring, Karol Kruczek, André Rebelo, Jason Lake, Michał Nowak
Research outputs 2022 to 2026
Background: Peak braking velocity (PBV) during the countermovement jump (CMJ) is used to describe descent strategy, but its interpretation is affected by countermovement depth. This study introduced free-fall normalised peak braking velocity (PBVFF), a dimensionless index expressing PBV relative to the displacement-specific theoretical free-fall velocity limit, and evaluated its reliability, performance associations and ranking consequences. Methods: Seventy injury-free male academy footballers (18.7 ± 1.6 years) performed three maximal hands-on-hips CMJs on dual force plates. Using retrospective observational routine monitoring data, one representative testing day per athlete was analysed. Two PBVFF variants were examined: PBVFF normalised to countermovement depth (PBVFFCMD) and …
Women’S Empowerment And Child Stunting In Peru: A Nationally Representative Analysis, Marisella Chumán-Sánchez, Brando Ortiz-Saavedra, Leonardo J. Uribe-Cavero, Anita P. Llamo-Vilcherrez, Joshua W. Moxey, Carlos J. Toro-Huamanchumo
Women’S Empowerment And Child Stunting In Peru: A Nationally Representative Analysis, Marisella Chumán-Sánchez, Brando Ortiz-Saavedra, Leonardo J. Uribe-Cavero, Anita P. Llamo-Vilcherrez, Joshua W. Moxey, Carlos J. Toro-Huamanchumo
Research outputs 2022 to 2026
Background: Child stunting remains a persistent public health challenge in Peru. Although women’s empowerment has been linked to improved child health, evidence on its domain-specific relationship with stunting remains limited. The objective of this study was to assess the association between women’s empowerment, across attitudes towards violence, social independence, and decision-making, and child stunting in Peru.
Methods: We conducted an analytical cross-sectional study using nationally representative data from the 2021 Demographic and Family Health Survey (ENDES), including 16,650 mother-child pairs. Analyses of women’s empowerment were conducted in a sub-sample with complete SWPER data (n = 12,696). Stunting was defined as …
Psychosocial, Mental, And Suboptimal Health Measures Are Not Affected By Provision Of Abdominal Aortic Calcification Imaging Results: A 12-Week Rct, Simone Radavelli-Bagatini, Lauren C. Blekkenhorst, Catherine P. Bondonno, Jack Dalla Via, Marc Sim, Abadi K. Gebre, James Dimmock, John T. Schousboe, Richard J. Woodman, Kun Zhu, Pawel Szulc, Ben Jackson, Wei Wang, Markus P. Schlaich, Douglas P. Kiel, Wai H. Lim, Amanda Devine, Moira Sim, Robin M. Daly, Jonathan M. Hodgson, Joshua R. Lewis
Psychosocial, Mental, And Suboptimal Health Measures Are Not Affected By Provision Of Abdominal Aortic Calcification Imaging Results: A 12-Week Rct, Simone Radavelli-Bagatini, Lauren C. Blekkenhorst, Catherine P. Bondonno, Jack Dalla Via, Marc Sim, Abadi K. Gebre, James Dimmock, John T. Schousboe, Richard J. Woodman, Kun Zhu, Pawel Szulc, Ben Jackson, Wei Wang, Markus P. Schlaich, Douglas P. Kiel, Wai H. Lim, Amanda Devine, Moira Sim, Robin M. Daly, Jonathan M. Hodgson, Joshua R. Lewis
Research outputs 2022 to 2026
Introduction: The provision of abdominal aortic calcification imaging results can elicit cardiovascular disease risk–reducing behaviors. However, its impact on psychosocial, mental, and suboptimal health measures is less clear.
Methods: Secondary analyses of a previously reported 12-week, single-blind RCT including 240 community-dwelling older Australian males and females were conducted. Participants were provided with abdominal aortic calcification imaging results and cardiovascular disease risk–reducing educational resources (abdominal aortic calcification+education, n =121) or education alone (control+education, n =119). Psychosocial distress, mental health score, and suboptimal health status were estimated using validated questionnaires. Linear mixed models were used to compare changes between groups across 12 …
Secondary Outcomes Of The Early Collaborative Intervention Eaci On Salivary Cortisol Co Regulation In Preterm Infants And Mothers, Evalotte Mörelius, Charlotte Sahlén Helmer, Thomas Abrahamsson, Elvar Theodorsson, Ulrika Birberg Thornberg
Secondary Outcomes Of The Early Collaborative Intervention Eaci On Salivary Cortisol Co Regulation In Preterm Infants And Mothers, Evalotte Mörelius, Charlotte Sahlén Helmer, Thomas Abrahamsson, Elvar Theodorsson, Ulrika Birberg Thornberg
Research outputs 2022 to 2026
The Early Collaborative Intervention (EACI) aims to strengthen early parent–infant relationships among moderate to late preterm infants in neonatal intensive care. This randomized controlled trial evaluated whether EACI influences mother–infant salivary cortisol co-regulation in mother–infant dyads, as well as infant cortisol reactivity and breast milk exposure during early infancy. Secondary outcomes were assessed in 54 dyads in the intervention group and 41 in the standard care group at one and four months’ corrected age. Salivary cortisol was collected before and after a bath at one month and a still-face procedure at four months. Significant mother–infant salivary cortisol co-regulation was observed …
Using Scoping Reviews As Precursors To Systematic Reviews: A Typology And Practical Guidance Derived From Eight Worked Examples, Hanan Khalil, Zachary Munn, Christina Godfrey, Micah D.J. Peters, Ellen Davies, Fiona Campbell, Danielle Pollock, Andrea C. Tricco, Dawid Pieper
Using Scoping Reviews As Precursors To Systematic Reviews: A Typology And Practical Guidance Derived From Eight Worked Examples, Hanan Khalil, Zachary Munn, Christina Godfrey, Micah D.J. Peters, Ellen Davies, Fiona Campbell, Danielle Pollock, Andrea C. Tricco, Dawid Pieper
Research outputs 2022 to 2026
Objectives: Scoping reviews are often conducted as a precursor to a systematic review (SR), yet guidance on how this relationship should be planned, executed, and reported is limited. We aimed to illustrate, through worked examples, the ways in which scoping reviews can function as precursors to SRs and to derive practical guidance for teams planning linked or sequential syntheses.
Study Design and Setting: We undertook a methodological analysis of eight contemporary evidence synthesis papers and protocols spanning veterinary medicine, animal welfare, public health, mental health, occupational health, and patient and public involvement, identified through the authors’ knowledge of the evidence …
Slushies Before School: Exploring How Nearby Food Outlets Impact The Eating Behaviours Of Secondary Students In Perth, Western Australia, Sharonna Mossenson, Klug, Joelie Mandzufas, Jacinta Francis, Siobhan Hickling, Lukar Thornton, Gina Trapp
Slushies Before School: Exploring How Nearby Food Outlets Impact The Eating Behaviours Of Secondary Students In Perth, Western Australia, Sharonna Mossenson, Klug, Joelie Mandzufas, Jacinta Francis, Siobhan Hickling, Lukar Thornton, Gina Trapp
Research outputs 2022 to 2026
The external school food environment, comprising food outlets and marketing near schools, shapes what young people eat. Yet little is known about how Australian adolescents perceive and navigate these environments. Focus groups were conducted with 31 school students (Years 7–12) from Perth, Western Australia, to explore their experiences of the external school food environment and its influence on their food-related behaviours. Transcripts were thematically analysed and six themes were identified. Accessibility emphasised proximity, transport links, opening hours and speed of service, with older students using outlets as social spaces. Availability of slushies, energy drinks, snacks and fast-food meal deals influenced …
Cardiovascular Disease And Fracture Risk In People With Type 2 Diabetes: A Nationwide Matched Case–Control Study, Aksayan Arunanthy Mahalingasivam, Annika Vestergaard Kvist, Joop P. Van Den Bergh, Cassandra Smith, Joshua R. Lewis, Peter Vestergaard, Nicklas Højgaard Hessellund Rasmussen
Cardiovascular Disease And Fracture Risk In People With Type 2 Diabetes: A Nationwide Matched Case–Control Study, Aksayan Arunanthy Mahalingasivam, Annika Vestergaard Kvist, Joop P. Van Den Bergh, Cassandra Smith, Joshua R. Lewis, Peter Vestergaard, Nicklas Højgaard Hessellund Rasmussen
Research outputs 2022 to 2026
To examine, among people with type 2 diabetes (T2D), whether cardiovascular disease (CVD) phenotypes and cardiovascular medications are associated with any fracture as the primary outcome and major osteoporotic fracture (MOF) as a secondary outcome. Nationwide registry-based matched case–control study in Denmark (2013–2021) among people with T2D. Cases were individuals with T2D who sustained an incident fracture (n = 12,390), and controls were fracture-free individuals with T2D matched 1:3 by age, sex, T2D onset date, and weighted Charlson Comorbidity Index (n = 37,170). The exposures were overall CVD, prespecified clinical CVD phenotypes (acute myocardial infarction (AMI), stroke, heart failure, atrial …
Cxcr3 Is Associated With T-Cell-Induced Heart Damage In Acute Rheumatic Fever, Francis M. Middleton, Reuben Mcgregor, Natalie Lorenz, Sarah Kilian, Anna E.S. Brooks, Saem Mul Park, Ciara Ramiah, Judith Tresidder, Timothy C. Barnett, Michael Serralha, William J. Martin, Florina Chan Mow, Glenn Pearson, Mark Mayo, David I. Broadhurst, Julie Bennett, Johann Brink, Nigel J. Wilson, Anna P. Ralph, Rachel H. Webb, P. Rod Dunbar, Jonathan Carapetis, Nicole J. Moreland
Cxcr3 Is Associated With T-Cell-Induced Heart Damage In Acute Rheumatic Fever, Francis M. Middleton, Reuben Mcgregor, Natalie Lorenz, Sarah Kilian, Anna E.S. Brooks, Saem Mul Park, Ciara Ramiah, Judith Tresidder, Timothy C. Barnett, Michael Serralha, William J. Martin, Florina Chan Mow, Glenn Pearson, Mark Mayo, David I. Broadhurst, Julie Bennett, Johann Brink, Nigel J. Wilson, Anna P. Ralph, Rachel H. Webb, P. Rod Dunbar, Jonathan Carapetis, Nicole J. Moreland
Research outputs 2022 to 2026
The pathogenesis of acute rheumatic fever (ARF) is poorly understood, limiting the development of immune-modulating therapies to treat disease and prevent progressive heart damage. Here, participants with definite ARF were compared to other severe acute paediatric conditions and matched healthy controls by profiling circulating immune molecules and cells to inform disease mechanisms and potential druggable pathways. ARF shared immunological similarities with other inflammatory conditions, including elevated serum IL-6 and an increased frequency of circulating CD4+ T cells. However, elevation of the chemokine CCL5 and immunoglobulin IgG3, along with reduced expression of the chemokine receptor CXCR3 in the T cell …
Anaemia In Pregnancy In Rural New South Wales: A Retrospective Study Of Prevalence, Risk Factors, And Guideline Adherence, Yuanwei Zhang, Esther Adama, Uchechukwu Levi Osuagwu
Anaemia In Pregnancy In Rural New South Wales: A Retrospective Study Of Prevalence, Risk Factors, And Guideline Adherence, Yuanwei Zhang, Esther Adama, Uchechukwu Levi Osuagwu
Research outputs 2022 to 2026
Aim: To determine the prevalence of anaemia in pregnancy in rural New South Wales (NSW) and assess the alignment of screening and treatment practices with the 2020 Australian Pregnancy Care Guidelines (APCG).
Methods: A retrospective cohort study at the Regional Hospital using records from 301 women who gave birth between 1st January and 4th September 2024. Data were sourced from eMaternity and PowerChart systems, focusing on haemoglobin and ferritin levels, demographic factors, iron deficiency risk factors, and birth outcomes.
Results: Iron deficiency was identified in 61.8% of women, with 6.0% diagnosed with iron deficiency anaemia (IDA). These rates were lower …
Chlorinated Drinking Water Exposure Enriches Antimicrobial Resistance Pathways In The Infant Gut Microbiome: A Randomized Trial, Kimberley Parkin, Claus T. Christophersen, Valerie Verhasselt, Debra J. Palmer, Matthew N. Cooper, Susan L. Prescott, Desiree Silva, David Martino
Chlorinated Drinking Water Exposure Enriches Antimicrobial Resistance Pathways In The Infant Gut Microbiome: A Randomized Trial, Kimberley Parkin, Claus T. Christophersen, Valerie Verhasselt, Debra J. Palmer, Matthew N. Cooper, Susan L. Prescott, Desiree Silva, David Martino
Research outputs 2022 to 2026
Background: Water chlorination is essential for controlling harmful microbes in drinking water; however, the antimicrobial effects of chlorine-based disinfectants present in tap water may influence early-life gut microbial ecology.
Objective: To investigate the functional and compositional impact of chlorinated drinking water on the gut microbiome of infants.
Design: The waTer qUality and Microbiome Study (TUMS) was an Australian-based double-blinded, randomised controlled trial. Six-month-old infants (n = 197) received either de-chlorinated drinking water via benchtop filtration (treatment, n = 99), or regular chlorinated water (control, n = 98) for twelve months. Tap water and stool samples were collected at baseline and …
Effects Of Lower Limb Joint Manipulation On Squat Strength And Ankle Range Of Motion: A Sham-Controlled Double-Blind Randomised Cross-Over Trial, Reneigh Morley-Hart, Barrett Losco, Alasdair R. Dempsey, G. Gregory Haff, Sasha L. Aspinall
Effects Of Lower Limb Joint Manipulation On Squat Strength And Ankle Range Of Motion: A Sham-Controlled Double-Blind Randomised Cross-Over Trial, Reneigh Morley-Hart, Barrett Losco, Alasdair R. Dempsey, G. Gregory Haff, Sasha L. Aspinall
Research outputs 2022 to 2026
Background: The back squat is a commonly prescribed exercise for developing lower body strength. The ability to squat can be affected by reduced ankle dorsiflexion range of motion (DF-ROM), leading to limited squat depth and dysfunctional compensatory movement patterns.
Objective: To investigate the effect of high-velocity low-amplitude lower limb manipulations on 1 repetition maximum (1RM) back squat strength, sagittal plane ankle kinematics during a squat, and active DF-ROM in individuals with asymptomatic deficits in DF-ROM.
Methods: Twenty-six enrolled; Twenty-four analysed resistance-trained participants with asymptomatic deficits in DF-ROM participated in this double-blind randomised sham-controlled cross-over trial. Interventions involved high-velocity low-amplitude joint …
My Story Is Good… It’S Not Like That For All: Uneven Access To Contraception Among Incarcerated Women In New South Wales, Australia, Helene Smith, Basil Donovan, Jocelyn Jones, Tony Butler, Paul Simpson
My Story Is Good… It’S Not Like That For All: Uneven Access To Contraception Among Incarcerated Women In New South Wales, Australia, Helene Smith, Basil Donovan, Jocelyn Jones, Tony Butler, Paul Simpson
Research outputs 2022 to 2026
Background: Evidence indicates high levels of unmet contraceptive need among justice-involved women, linked to intersecting vulnerabilities such as housing instability, substance use, violence and poor mental health. In Australia, limited research has explored how women in prison navigate access to family planning services. This study aimed to examine the experiences of incarcerated women in New South Wales (NSW) in accessing contraception and making fertility-related decisions.
Methods: The study formed part of the Second Sexual Health and Attitudes of Australian Prisoners (SHAAP-2) study. Seventeen women aged 19–45 were recruited from two NSW correctional centres. Semi-structured qualitative interviews were conducted face-to-face or …
Body Mass Index, Prebiotic Supplementation During Pregnancy And Gestational Diabetes Mellitus Risk: An Effect Modification Analysis From A Randomised Controlled Trial, Rachelle A. Pretorius, Thomas R. Sullivan, Summer V.M. Walker, Johan Garssen, Jeffrey A. Keelan, Desiree Silva, Susan L. Prescott, Debra J. Palmer
Body Mass Index, Prebiotic Supplementation During Pregnancy And Gestational Diabetes Mellitus Risk: An Effect Modification Analysis From A Randomised Controlled Trial, Rachelle A. Pretorius, Thomas R. Sullivan, Summer V.M. Walker, Johan Garssen, Jeffrey A. Keelan, Desiree Silva, Susan L. Prescott, Debra J. Palmer
Research outputs 2022 to 2026
Background: Prebiotic dietary supplementation has been shown to improve glucose homeostasis in type 2 diabetes patients. The aim of this analysis was to determine whether pre-pregnancy body mass index (BMI) modifies the effect of prebiotic supplementation from mid-pregnancy on reducing the risk of gestational diabetes mellitus (GDM). Methods: In a double-blinded, randomised controlled trial, pregnant women < 21 gestational weeks were randomly assigned (1:1) to consume daily prebiotics (14.2 g galacto-oligosaccharides and fructo-oligosaccharides) or placebo (8.7 g maltodextrin) powder. An effect modification analysis was performed to assess the heterogeneity of the effect of prebiotic supplementation in relation to pre-pregnancy BMI on GDM diagnosis. Results: Between June 2016 and November 2021, 329 women were assigned to the prebiotic group (50.4%), and 323 (49.5%) were assigned to the placebo group. Overall, 288 of 652 women (44.2%) were classified as overweight/obese prior to pregnancy (BMI ≥ 25 kg/m2). The distribution was balanced, with 146/329 (44.4%) randomised to the prebiotics group and 142/323 (44.0%) in the placebo group. Pre-pregnancy BMI modified the effect of prebiotic supplementation, with the intervention reducing GDM rates in women with a BMI ≥ 25 kg/m2 …
Co-Design And Feasibility Testing Of A Midwife-Led Birth Debrief: An Implementation Science Project, Kate Buchanan, Phoebe Backhouse, Leanne Graham, Amy O’Meagher, Sara Bayes
Co-Design And Feasibility Testing Of A Midwife-Led Birth Debrief: An Implementation Science Project, Kate Buchanan, Phoebe Backhouse, Leanne Graham, Amy O’Meagher, Sara Bayes
Research outputs 2022 to 2026
Background: The period spanning pregnancy, birth and postpartum is characterised by psychosocial as well as physiological changes: many women experience new or worsening mental ill-health during the perinatal period. Midwives play a critical role in supporting and promoting psychosocial health by providing mental health education, counselling and screening. Often this includes a post-birth conversation, guided reflection, or debrief. Information about the effectiveness and experiences of specific and structured midwife-led birth debrief is scant. Aim: Our study aimed to assess the perceived effectiveness, experiences and implementability of a midwife-led birth debriefing intervention in one Australian maternity unit. Methods: A Type II …
Paternal Age And Offspring Bone Health And Body Composition At 20 Years: Findings From The Raine Study, Mia A. Percival, Kun Zhu, John P. Walsh, Marc Sim, Kara B. Anderson, Julie A. Pasco, Natalie K. Hyde
Paternal Age And Offspring Bone Health And Body Composition At 20 Years: Findings From The Raine Study, Mia A. Percival, Kun Zhu, John P. Walsh, Marc Sim, Kara B. Anderson, Julie A. Pasco, Natalie K. Hyde
Research outputs 2022 to 2026
Aims: There is growing evidence supporting paternal contributions to child health. Previous findings from the Vitamin D In Pregnancy study suggest that advanced paternal age is associated with a range of poorer bone measures for offspring at age 11 years. Whether these associations are evident when peak bone mass is attained remains unknown. This study aimed to investigate associations between paternal age and offspring bone health and body composition at age 20 years.
Methods: Data from the Raine study, a multigenerational cohort, were used. Among 1183 offspring with total body DXA data (Norland XR-36 densitometer) at the 20-year follow up, …
The Effectiveness Of Cluster Vs. Rest-Redistribution Set Configurations To Maintain Movement Velocity During Resistance Training: A Systematic Review And Bayesian Network Meta-Analysis, Tsuyoshi Nagatani, Christopher Latella, Jiahao Yang, Kristina L. Kendall, Shayne Vial, Paul Comfort, Eric J. Drinkwater, G. Gregory Haff
The Effectiveness Of Cluster Vs. Rest-Redistribution Set Configurations To Maintain Movement Velocity During Resistance Training: A Systematic Review And Bayesian Network Meta-Analysis, Tsuyoshi Nagatani, Christopher Latella, Jiahao Yang, Kristina L. Kendall, Shayne Vial, Paul Comfort, Eric J. Drinkwater, G. Gregory Haff
Research outputs 2022 to 2026
Background: Alternative set structures such as cluster sets (CS) and rest-redistribution (RR) are often used as a more effective method for preserving movement velocity during resistance training than traditional sets (TS). However, only a limited number of studies have directly compared CS and RR, and their relative effectiveness has not been comprehensively synthesized. The aim of this present study was to systematically synthesize the existing literature examining acute effects of CS and RR on movement velocity during resistance training, compare CS and RR using Bayesian network meta-analyses, and examine potential moderators of these effects using Bayesian network meta-regressions.
Methods: Two …
Sarcomerogenesis: Evidence, Context And Key Stimuli—Response To The Commentary By Power Et Al., Anthony J. Blazevich, Walter Herzog, João Pedro Nunes
Sarcomerogenesis: Evidence, Context And Key Stimuli—Response To The Commentary By Power Et Al., Anthony J. Blazevich, Walter Herzog, João Pedro Nunes
Research outputs 2022 to 2026
No abstract provided.
Application Of The Paediatric Medical Traumatic Stress Model To The Mental Health Experience Of Young People Living With Type 1 Diabetes: A Qualitative Study, Rigel Paciente, Sara Coombs, Karen Lombardi, Helen Milroy, Keely Bebbington, Heather Roby, Craig E. Taplin, Nicole Wickens, Stella Rose, Alix Woolard
Application Of The Paediatric Medical Traumatic Stress Model To The Mental Health Experience Of Young People Living With Type 1 Diabetes: A Qualitative Study, Rigel Paciente, Sara Coombs, Karen Lombardi, Helen Milroy, Keely Bebbington, Heather Roby, Craig E. Taplin, Nicole Wickens, Stella Rose, Alix Woolard
Research outputs 2022 to 2026
Despite the various traumatic events that a young person living with type 1 diabetes (T1D) may experience, little is known about the burden and manifestation of traumatic stress in this population. Though mental health outcomes have been explored generally, medical trauma-sensitive approaches to understanding these experiences remain limited. We utilised a qualitative descriptive approach to explore the impact of T1D on young people’s mental health through the paediatric medical traumatic stress model (PMTS). Young people aged 13–30 living with T1D were interviewed. These interviews were recorded, transcribed, and analysed using Reflexive Thematic Analysis. Three main themes were generated: (1) perceived …