Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (2466)
- University of Nebraska - Lincoln (2219)
- Aga Khan University (1460)
- Washington University School of Medicine (1086)
- Thomas Jefferson University (1062)
-
- TÜBİTAK (796)
- University of Kentucky (722)
- Walden University (686)
- University of Nebraska Medical Center (569)
- Western Michigan University (546)
- Himmelfarb Health Sciences Library, The George Washington University (529)
- Children's Mercy Kansas City (453)
- Universitas Indonesia (406)
- Chulalongkorn University (402)
- Touro College and University System (381)
- Virginia Commonwealth University (361)
- University of Louisville (346)
- University of Texas Rio Grande Valley (342)
- University of South Carolina (339)
- Dartmouth College (282)
- City University of New York (CUNY) (268)
- Nova Southeastern University (264)
- HCA Healthcare (258)
- Edith Cowan University (255)
- University of Nevada, Las Vegas (254)
- University of Alabama at Birmingham (250)
- Zucker School of Medicine at Hofstra/Northwell (249)
- Old Dominion University (246)
- Providence (236)
- University of South Florida (236)
- Keyword
-
- Humans (2675)
- COVID-19 (2286)
- Female (1108)
- Male (933)
- Animals (736)
-
- SARS-CoV-2 (724)
- Adult (698)
- HIV (577)
- ICTS (Institute of Clinical and Translational Sciences) (547)
- Child (499)
- Middle Aged (489)
- Public health (487)
- Michigan (478)
- Mice (461)
- Symptoms (458)
- Syndromic surveillance (443)
- United States (405)
- Aged (355)
- Adolescent (334)
- Vaccination (321)
- Tuberculosis (316)
- Epidemiology (313)
- Coronavirus (302)
- Infant (298)
- Anti-Bacterial Agents (253)
- Vaccine (252)
- Immunotherapy (239)
- HIV Infections (238)
- Pregnancy (231)
- Pandemic (227)
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (1154)
- Faculty, Staff and Students Publications (1008)
- 2020-Current year OA Pubs (803)
- Walden Dissertations and Doctoral Studies (658)
- Turkish Journal of Medical Sciences (593)
-
- United States Department of Agriculture Wildlife Services: Staff Publications (592)
- Michigan COVID-19 Syndromic Surveillance System Data (442)
- School of Veterinary and Biomedical Sciences: Faculty Publications (358)
- Theses and Dissertations (308)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (305)
- Nebraska Center for Virology: Faculty Publications (268)
- Faculty Publications (267)
- Dartmouth Scholarship (266)
- Journal Articles (251)
- Manuscripts, Articles, Book Chapters and Other Papers (251)
- Electronic Theses and Dissertations (250)
- Department of Paediatrics and Child Health (231)
- Trematoda Taxon Notebooks (212)
- Turkish Journal of Veterinary & Animal Sciences (203)
- All ETDs from UAB (183)
- Publications and Research (177)
- School of Medicine Publications (176)
- Open Access Publications (175)
- The University of Louisville Journal of Respiratory Infections (174)
- USF Tampa Graduate Theses and Dissertations (166)
- Zoonotics and Wildlife Disease: Publications (163)
- Graduate Medical Education Research Journal (157)
- Dissertations and Theses (Open Access) (152)
- Dissertations (129)
- Journal Articles: Epidemiology (122)
- Publication Type
- File Type
Articles 27121 - 27150 of 28243
Full-Text Articles in Entire DC Network
What's Happening: August 14, 1991, Maine Medical Center
What's Happening: August 14, 1991, Maine Medical Center
What's Happening
No abstract provided.
Impact Of Follow-Up Encounters By A Geriatric Nurse Clinician On Return Visits To The Emergency Department By Elderly Clients, Lynn Smith
MSN Research Projects
Wiedenbach's Theory of Nursing as the helping art was the framework for this quasi-experimental study. This study sought to determine the effects of a follow-up encounter by a Geriatric Nurse Clinician on return visits to the emergency department by elderly clients. A nonprobability quota sampling consisted of elders, 65 to 92 years of age with chronic health problems, who utilized the emergency department of a 474-bed urban hospital. Thirty subjects were randomly assigned to three equal groups: Groups A and B received either a telephone call or a home visit, while Group C received no follow-up encounter. Demographic data were …
Oncolog, Volume 36, Issue 03, July-September 1991, Emil J. Freireich Md, James M. Bowen Phd
Oncolog, Volume 36, Issue 03, July-September 1991, Emil J. Freireich Md, James M. Bowen Phd
OncoLog MD Anderson's Report to Physicians (All issues) Archives
- From cell culture to clinical protocol: In cancer research, the goals of scientist and clinician converge New clinic treats depressed cancer patients
- Half-century of progress in leukemia research
Use Of Pollen Concentration In Paleopharmacology: Coprolite Evidence Of Medicinal Plants, Karl Reinhard, Donny L. Hamilton, Richard H. Hevly
Use Of Pollen Concentration In Paleopharmacology: Coprolite Evidence Of Medicinal Plants, Karl Reinhard, Donny L. Hamilton, Richard H. Hevly
Karl Reinhard Publications
Nearly 2,400 plant species have been documented ethnographically as having medicinal value among Native Americans. Therefore, it is not surprising that evidence of medicinal plants appears in some of the over 1,000 coprolites analyzed from the southwestern U.S. Three medicinal species identified in pollen analysis of coprolites are discussed. Willow (Salix) is the most common analgesic in the Native American pharmacopoeia. Prehistoric use of this plant is documented in coprolites from Bighorn Cave in the Black Mountains of Arizona and also in a burial from the Mimbres Valley, New Mexico. Historically, Mormon tea (Ephedra) served as …
Antimicrobial Chemotherapy In The Intensive Care Unit, Louis D. Saravolatz
Antimicrobial Chemotherapy In The Intensive Care Unit, Louis D. Saravolatz
Henry Ford Hospital Medical Journal
No abstract provided.
Porcine Bioprosthetic Aortic Valve Endocarditis With Ring Abscess And Aortic Stenosis, Reda A. Girgis, Howard Rosman, Ramon Del Busto, Maryann Fitzmaurice, Norman A. Silverman
Porcine Bioprosthetic Aortic Valve Endocarditis With Ring Abscess And Aortic Stenosis, Reda A. Girgis, Howard Rosman, Ramon Del Busto, Maryann Fitzmaurice, Norman A. Silverman
Henry Ford Hospital Medical Journal
Porcine bioprosthetic valve endocarditis is an infrequent but serious complication of valve replacement surgery. Ring (or annular) abscess is a frequent finding in mechanical valve endocarditis. In contrast, porcine valve endocarditis most often involves the cusps, and annular infection is uncommon. Porcine valvular dysfunction secondary to endocarditis usually takes the form of incompetence, whereas stenosis is less frequent. We report a case of a 76-year-old female who developed endocarditis wilh Staphylococcus epidermidis nine months after placement of a Carpenter-Edwards porcine aortic valve. Her initial presentation included complete heart block and moderate aortic stenosis. Transesophageal echocardiography aided the diagnosis by demonstrating …
The Development Of Mental Health Services In Sub-Saharan Africa: The Case Of Rwanda, Froduald Gatarayiha, Franz Baro, Morton O. Wagenfeld, Rene Stockman
The Development Of Mental Health Services In Sub-Saharan Africa: The Case Of Rwanda, Froduald Gatarayiha, Franz Baro, Morton O. Wagenfeld, Rene Stockman
The Journal of Sociology & Social Welfare
This paper considers several aspects of the evolution, organization and current status of the mental health system of Rwanda. The centerpiece of the Rwandan mental health system is the neuropsychiatric hospital in Ndera. Resource constraints preclude development of an extensive system of specialty mental health care. The World Health Organization has proposed that mental health services can best be delivered in developing countries through decentralization and integration with primary health care services. The accomplishments and problems encountered in implementing this model in Rwanda are described and, based on this experience, some recommendations are offered for other developing countries.
A Cross-Cultural Perspective On Selected Mental Health Systems, Gary Mathews, Morton O. Wagenfeld
A Cross-Cultural Perspective On Selected Mental Health Systems, Gary Mathews, Morton O. Wagenfeld
The Journal of Sociology & Social Welfare
The information provided from authors around the world on their respective mental health systems is analyzed and compared. Several key dimensions are utilized, including the relationship of mental health services to other services, institutional care, community care, staffing, prevention and mental health promotion services, and accessibility. Resources and governmental priorities are identified as being essential to the provision of effective services. It is clear that the general trends identified by the experts for mental health in both developing and developed countries are by no means universal in applicability.
Cytolytic And Ion Channel Forming Properties Of The N-Terminus Of Lymphocyte Perforin, David M. Ojcius, Pedro M. Persechini, Li-Mou Zheng, Paulo C. Notaroberto, Sandro C. Adeodato, John Ding-E. Young
Cytolytic And Ion Channel Forming Properties Of The N-Terminus Of Lymphocyte Perforin, David M. Ojcius, Pedro M. Persechini, Li-Mou Zheng, Paulo C. Notaroberto, Sandro C. Adeodato, John Ding-E. Young
All Dugoni School of Dentistry Faculty Articles
Perforin lyses cells by binding to the target cell membrane, where it polymerizes into large nonspecific pores. It is shown here that the first 34 amino acids of the N-terminal region of either human or murine perforin are soluble in aqueous medium and spontaneously insert into membranes. The N-terminal peptides lyse liposomes and nucleated cells, and they form ion channels in planar bilayers, some of which are comparable to those previously described for perforin. The lytic activity of the N-terminal domains does not require calcium, is independent of the lipid headgroup composition, and can be inhibited by heparin. Tumor cells …
Mental Health Services In Egypt, A. Okasha
Mental Health Services In Egypt, A. Okasha
The Journal of Sociology & Social Welfare
This paper begins with a historical perspective on mental health care from ancient Egypt to modern times. Current mental health services are described including epidemiological information, the structure of services, and methods of service delivery. Contrasts are made between urban and rural community care systems. The changing demographics of institutional care are analyzed in detail and future plans for psychiatric services are discussed. The recent development of comprehensive interdisciplinary model of service and the founding of a training center for this model is described.
Effect Of Delays In Processing On The Survival Of Mycobacterium Avium-M. Intracellulare In The Isolator Blood Culture System., C. Fordham Von Reyn, Stephen Hennigan, Sandra Niemczyk, Nicholas J. Jacobs
Effect Of Delays In Processing On The Survival Of Mycobacterium Avium-M. Intracellulare In The Isolator Blood Culture System., C. Fordham Von Reyn, Stephen Hennigan, Sandra Niemczyk, Nicholas J. Jacobs
Dartmouth Scholarship
Concentrations of Mycobacterium avium-M. intracellulare ranging from 10(-1) to 10(3) CFU/ml were added to blood, placed in Isolator tubes, and held at room temperature for intervals ranging from 4 h to 56 days before being processed (centrifugation and culture on Middlebrook 7H10 agar). At all concentrations tested, M. avium-M. intracellulare was recovered after hold times ranging from 4 h to 7 days; the number of final CFU actually increased progressively for hold times of 8 h or more. Hold times of up to 7 days did not increase the time from processing to the first appearance of visible colonies. At …
Virtue And The Health Professions, Janet Pisaneschi
Virtue And The Health Professions, Janet Pisaneschi
Center for the Study of Ethics in Society Papers
Presented to the WMU Center for the Study of Ethics in Society, February 8, 1991.
Promoting Careers In Dental Hygiene: The Dental Hygienist's Role, Taline Dadian
Promoting Careers In Dental Hygiene: The Dental Hygienist's Role, Taline Dadian
Dental Hygiene Theses & Dissertations
The purpose of this study was to investigate whether practicing dental hygienists promote their profession as a desirable career. A self-designed, 48 item questionnaiire, Dental Hygienists' Participation in Career Recruitment, was mailed to a random sample of 600 dental hygienists residing in the Commonwealth of Virginia. Data were obtained from 393 dental hygienists for a 65.5 percent response rate. Responses from each item were analyzed by frequency distributions, percentages and chi-square test for independence at a 0.05 level of confidence. The factors determined to influence dental hygienists' decisions towards promoting careers in dental hygiene included the perceived image of the …
Development And Characterization Of Monoclonal Antisperm Antibodies: Potential For Contraception, Dilrowshan H. Haque
Development And Characterization Of Monoclonal Antisperm Antibodies: Potential For Contraception, Dilrowshan H. Haque
Theses and Dissertations in Biomedical Sciences
There is an expressed need to develop a greater variety of safe contraceptive methods which would find acceptance worldwide, particularly in developing countries. Immunization against spermatozoa might be such a method as judged by the accumulated evidence from studies on human females and in a number of female animal species.
Two extraction techniques were used for sperm membrane antigen isolation. The first technique involved NP-40 detergent for antigen extraction from human motile sperm and the second technique employed homogenized human testis for antigen extraction. Using these immunogens, sperm membrane-specific monoclonal antibodies (MAbs) were developed. When these antisperm MAbs were subjected …
Identification Of Health Promotion Behaviors, Perceived Health Status And Perceived Health Education Needs Of Older Women, Susan Carol Fellinger Reynolds
Identification Of Health Promotion Behaviors, Perceived Health Status And Perceived Health Education Needs Of Older Women, Susan Carol Fellinger Reynolds
Ellmer School of Nursing Theses & Dissertations
The health-promoting behaviors, perceived health status, and perceived health education needs of older women were identified in this non-experimental, descriptive, correlational study. Fifty women over 60 years of age, living in three housing complexes for the elderly, disabled and handicapped in two southeastern United States cities were asked to complete The Health-Promoting Lifestyle Profile, The Perceived Health Status Questionnaire, The Health Education Needs Questionnaire, and Demographic Data Sheet. It was concluded that the women engaged in a high level of health-promoting behaviors. The participants rated their health as good and rated their health as good compared to that of other …
Amalgam Fillings: Do Dental Patients Have A Right To Informed Consent, Michael A. Royal
Amalgam Fillings: Do Dental Patients Have A Right To Informed Consent, Michael A. Royal
RISK: Health, Safety & Environment (1990-2002)
Recent animal studies have shown significant mercury absorption from dental fillings and resulted in unfavorable media attention. Yet, an FDA advisory committee has found no evidence of Risk to dental patients, and many dentists believe that patients are being unnecessarily alarmed. The paper reviews the history of amalgam fillings through the recent animal studies and concludes that the Risk, whatever it may prove to be, is sufficiently high to warrant permitting patients to choose between amalgam and alternative dental filling materials.
Cells That Express All Five Proteins Of Vesicular Stomatitis Virus From Cloned Cdnas Support Replication, Assembly, And Budding Of Defective Interfering Particles, Asit K. Pattnaik, Gail W. Wertz
Cells That Express All Five Proteins Of Vesicular Stomatitis Virus From Cloned Cdnas Support Replication, Assembly, And Budding Of Defective Interfering Particles, Asit K. Pattnaik, Gail W. Wertz
School of Veterinary and Biomedical Sciences: Faculty Publications
An alternative approach to structurefunction analysis of vesicular stomatitis virus (VSV) gene products and their interactions with one another during each phase of the viral life cycle is described. We showed previously by using the vaccinia viruslT7 RNA polymerase expression system that when cells expressing the nucleocapsid protein (N), the phosphoprotein (NS), and the large polymerase protein (L) of VSV were superinfected with defective interfering (DI) particles, rapid and efflicient replication and amplification of DI particle RNA occurred. Here, we demonstrate that all five VSV proteins can be expressed simultaneously when cells are cotransfected with plasmids containing the matrix protein …
Southeastern University Of The Health Sciences Catalog 1991-1993, Southeastern University
Southeastern University Of The Health Sciences Catalog 1991-1993, Southeastern University
Health Professions Divisions Course Catalogs and Course Descriptions
No abstract provided.
Self-Esteem And Blood Pressure, Cholesterol, Thyroxine And Leukocytes, Dorothy Louise Vela-Melton
Self-Esteem And Blood Pressure, Cholesterol, Thyroxine And Leukocytes, Dorothy Louise Vela-Melton
Theses Digitization Project
No abstract provided.
Habitat Associations And Relative Densities Of Rodent Populations In Cultivated Areas Of Central Argentina, James N. Mills, Barbara A. Ellis, Kelly T. Mckee, Julio I. Maiztegui, James E. Childs
Habitat Associations And Relative Densities Of Rodent Populations In Cultivated Areas Of Central Argentina, James N. Mills, Barbara A. Ellis, Kelly T. Mckee, Julio I. Maiztegui, James E. Childs
Zoonotics and Wildlife Disease: Publications
Small mammals were livetrapped during 12 months in crop fields and weedy borders at 18 sites in central Argentina. A total of 1,652 mammals of 14 species was captured during3 3,060 trap-nights. Six species of rodents comprised > 95% of captures. Periodically disturbed fields of crops were dominated by Calomys musculinus and C. laucha, and to a lesser extent Mus musculus. A second group composed of Akodon azarae, Bolomys obscures, and Oligoryzomys flavescens primarily inhabited the more stable, weedy borders of cultivated fields. Peaks in relative densities of C. musculinus, C. laucha, and M . musculus …
Evaluation Of The Role Of Shiga And Shiga-Like Toxins In Mediating Direct Damage To Human Vascular Endothelial Cells, Vernon L. Tesh, James E. Samuel, Liyanage P. Perera, John B. Sharefkin, Alison D. O'Brien
Evaluation Of The Role Of Shiga And Shiga-Like Toxins In Mediating Direct Damage To Human Vascular Endothelial Cells, Vernon L. Tesh, James E. Samuel, Liyanage P. Perera, John B. Sharefkin, Alison D. O'Brien
Uniformed Services University of the Health Sciences
Infection with Shinga toxin- and Shinga-like toxin -producing strains of Shigella dysenteriae and Escherichia coli, respectively, can progress to the hemolytic-uremic syndrome. It has been hypothesized that circulating Shinga toxin, Shinga-like toxins, and endotoxins may contribute to the disease by directly damaging glomerular endothelial cells. The effects of these toxins on HeLa, Vero, and human vascular endothelial cells (EC) were examined. Confluent EC were sensitive to Shinga toxin but were at least 106-fold less sensitive to the toxins than were Vero cells. Shinga toxin was the predominant cytotoxic factor. Lipopolysaccharides were not cytotoxic and did not augment …
Molecular Epidemiologic Techniques In Analysis Of Epidemic And Endemic Shigella Dysenteriae Type 1 Strains, Nancy A. Strockbine, Julie Parsonnet, Katherine Greene, Julia A. Kiehlbauch, I. Kaye Wachsmuth
Molecular Epidemiologic Techniques In Analysis Of Epidemic And Endemic Shigella Dysenteriae Type 1 Strains, Nancy A. Strockbine, Julie Parsonnet, Katherine Greene, Julia A. Kiehlbauch, I. Kaye Wachsmuth
United States Public Health Resources
During 1988 the number of Shigella dysenteriae type 1 infections reported in the United States increased fivefold. To determine if recent isolates from Mexico were related to those that caused epidemics of dysentery worldwide, Southern hybridization analysis was done with Shiga toxin and ribosomal RNA gene probes. Western hemisphere and Eastern Hemisphere strains differed by the size of a single EcoRI fragment carrying the Shiga toxin genes. Three ribosomal DNA (rDNA) patterns were observed, which correlated with the strain;s continental origin for 81 of 83 isolates tested. Together the Shiga toxin and rDNA probe results indicated that recent Mexican …
New Technique Joins The Fight Against Footrot, Laurie Depiazzi, Mike Palmer, David Pitman
New Technique Joins The Fight Against Footrot, Laurie Depiazzi, Mike Palmer, David Pitman
Journal of the Department of Agriculture, Western Australia, Series 4
The diagnosis of footrot in sheep and goats is not an easy task. Two main techniques are used for diagnosis - inspection of diseased feet on a farm and laboratory testing of bacteria isolated from foot scrapings. The interpretation of the results obtained by these methods requires a good understanding of the various forms of footrot.
A new laboratory technique has halved the time taken to detect those strains of the bacterium, Bacteroides (Dichelobacter) nodosus, that cause each form of the disease.
Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1991), Philadelphia College Of Osteopathic Medicine
Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 1991), Philadelphia College Of Osteopathic Medicine
Digest
The Winter 1991 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:
- A Master Plan to Grow on: City Avenue Campus
- Emanuel Fliegelman, DO: Reminding Us That to be Human is to be Best
- PCOM's Computer Hospital: High-tech Medical Education
- New Appointments
- On Campus
- Just Published
- Class Acts
- In Memoriam
- Coming Events
Kronos [1991], State University Of New York At Stony Brook, School Of Medicine
Kronos [1991], State University Of New York At Stony Brook, School Of Medicine
Kronos (School of Medicine)
This edition of Kronos, published in 1991, is the official yearbook of the State University of New York at Stony Brook, School of Medicine. Hard-bound.
The Effect Of Psychosocial Factors On The Immune Response Of Hiv Infected Individuals As Measured By The Extent Of Relationship With Cd-4 T Cell Count And Physical Symptoms, Richard R. Taylor
Theses
The effect of psychosocial factors on the immune response of HIV infected human subjects was assessed by measuring the degree of relationship to CD-4 T cell count and physical symptoms.
Twenty six participants (22 white and 2 black males) all who had been diagnosed as HIV positive completed a battery of 11 psychological tests and a social and medical history questionnaire. Fifty four psychosocial factors were selected as having the potential to have a significant effect on immune response.
Correlational analyses yielded no strong relationships between the psychosocial factors and CD-4 T cell count or physical symptoms. Moderate associations were …
Enhancement Of Human Immunodeficiency Virus Type 1 Infection By Cationic Liposomes: The Role Of Cd4, Serum And Liposome-Cell Interactions, Krystyna Konopka, L. L. Stamatatos, C. E. Larsen, B. R. Davis, Nejat Düzgüneş
Enhancement Of Human Immunodeficiency Virus Type 1 Infection By Cationic Liposomes: The Role Of Cd4, Serum And Liposome-Cell Interactions, Krystyna Konopka, L. L. Stamatatos, C. E. Larsen, B. R. Davis, Nejat Düzgüneş
All Dugoni School of Dentistry Faculty Articles
We have reported previously the enhancement of the infectivity of human immunodeficiency virus type 1 (HIV- 1) by liposomes composed of the cationic lipid N[2,3-(dioleyloxy) propyl]-N,N,N-trimethylammonium chloride (DOTMA). To determine the mechanism by which this process occurs, we have investigated the role of CD4, serum concentration and liposome-cell interactions in the DOTMA-mediated stimulation of HIV-1 infection of A3.01 cells. Serum alone significantly inhibited the binding and infectivity of HIV-1, but DOTMA-mediated enhancement of infectivity was more pronounced in the presence of serum than in its absence. HIV-1 binding to cells was increased in the presence of DOTMA liposomes, DEAE-dextran and …
Monoclonal Antibodies To The Fusion Protein Of Bovine Respiratory Syncytial Virus, Kent M. Mulkey, Gary A. Anderson
Monoclonal Antibodies To The Fusion Protein Of Bovine Respiratory Syncytial Virus, Kent M. Mulkey, Gary A. Anderson
School of Veterinary and Biomedical Sciences: Faculty Publications
Five monoclonal antibodies specific for bovine respiratory syncytial virus were characterized by Western immunoblotting, radioimmunoprecipitation, and epitope mapping assays. The monoclonal antibodies were found to be specific for the fusion protein, and there were at least two antigen binding sites, one of which was neutralizing.
Dietary And Parasitological Analysis Of Coprolites Recovered From Mummy 5, Ventana Cave, Arizona, Karl Reinhard, Richard H. Hevly
Dietary And Parasitological Analysis Of Coprolites Recovered From Mummy 5, Ventana Cave, Arizona, Karl Reinhard, Richard H. Hevly
Karl Reinhard Publications
Four coprolites were excavated with Burial 5 at Ventana Cave. a partially mummified five-year-old child. Two coprolites were granular and dark in color and two were fibrous and light in color. The coprolites are remains of the child's intestinal contents and were submitted for dietary and parasitological analysis. No parasites were found. The fibrous coprolites proved to be remains of highly masticated mesquite pods (Prosopis). The granular coprolites consist of seeds of saguaro cactus (Carnegiea gigantea). Pollen analysis reveals two dietary pollen types, both derived from cactus. No evidence of cultivated plants except for a trace amount of …
Pharmacokinetics, Immune Response, And Biodistribution Of Iodine-131-Labeled Chimeric Mouse/Human Igg1, K 17-1a Monoclonal Antibody, Ruby Meredith, Albert Lobuglio, Walter Plott, Roger Orr, Ivan Brezovich, Charles Russell, Elizabeth Harvey, Michael Yester, Mansoor Saleh
Pharmacokinetics, Immune Response, And Biodistribution Of Iodine-131-Labeled Chimeric Mouse/Human Igg1, K 17-1a Monoclonal Antibody, Ruby Meredith, Albert Lobuglio, Walter Plott, Roger Orr, Ivan Brezovich, Charles Russell, Elizabeth Harvey, Michael Yester, Mansoor Saleh
Haematology and Oncology, East Africa
Pharmacokinetics,immunogenicity,and biodistributionof a 131I-Iabeledmouse/human chimenc monoclonal antibody (C17-1A) was studiedin six metastaticcoloncancerpatients. Pharmacokinetics obtalned from serum radioactivity or chi mera concentration were identical after 5 mCi of 131I(>17-1A withmeanalphahalf-livesof 17.6±2.3 and19.7±2.9 and meanbeta half-livesof 100.9±16.1 and 106.4±14.1 hr, respectively. HPLC analysis documented the monomeric chi rneiic17-lA withoutevidenceof immunecomplexesorfree 1311 None of the patients developed antibody after ‘31I-chi merle17-1A exposure.Radiolocalizationoccurredin known areas of disease >4 cm in all patients. The half-life of total body radioactivity was 58 ±7 hr by whole-body counts and 64 ±13 hr by urine measurements. Whole-body and bone marrow dose estimates ranged from 0.75-1 .03 and …