Digital Commons Network^™

Commencement, Philadelphia (2000), Philadelphia College Of Osteopathic Medicine

Commencements

Philadelphia Campus D.O. Commencement Program, 109th Class. Degrees include Doctor of Osteopathic Medicine.

Commencement Speaker: Donna E. Shalala, Secretary, U.S. Department of Health and Human Services

Com Outlook June 2000, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Center For Professional Ethics, Volume 2, Issue 4, 2000, Case Western Reserve University

Center for Professional Ethics

Table of Contents:

• Two Branches of the Ethics Family Tree: Edward Lawry named visiting Ethics Fellow
• Ethical Responsibilities in Higher Education: Experiential Learning as a Model for Reform
• When Push Come to Shove: Forced Treatment in the Community Setting
• Director's Corner: Surviving Survivor by Robert P. Lawry
• Summer 2000: News, Notes, and Future Events

Becoming Advocates For Battered Women, Julie G. Stewart

Nursing Faculty Publications

Through her research, an advanced practice nurse has identified five stages through which abused women proceed on their way to freedom. The author calls on all clinicians to become advocates for battered women by recognizing them in clinical practice and helping them find the road to a life of safety, peace, and restored self-esteem.

Efflux Of Osmolyte Amino Acids During Isovolumic Regulation In Hippocampal Slices, Rodrigo Franco, Octavio Quesada, Herminia Pasantes-Morales

School of Veterinary and Biomedical Sciences: Faculty Publications

The efflux of potassium (K⁺) and amino acids from hippocampal slices was measured after sudden exposure to 10% (270 mOsm), 25% (225 mOsm) or 50% (150 mOsm) hyposmotic solutions or after gradual decrease (22.5 mOsm/min) in external osmolarity. In slices suddenly exposed to 50% hyposmotic solutions, swelling was followed by partial (74%) cell volume recovery, suggesting regulatory volume decrease (RVD). With gradual hyposmotic changes, no increase in cell water content was observed even when the solution at the end of the experiment was 50% hyposmotic, showing the occurrence of isovolumic regulation (IVR). The gradual decrease in osmolarity elicited …

Ada News - 05/01/2000, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Factors Influencing Compliance In The Treatment Of Elderly Hypertensive Vietnamese Clients, Cuong Phu Pham

Master's Projects

Little is known about health care beliefs and practices among Vietnamese elderly persons living in the United States. In general, studies of patient compliance with medical advice consistently demonstrate a high level of noncompliance. Not following recommendations can have serious negative consequences in the management of disease. The purpose of this study was to investigate compliance among a group of elderly Vietnamese clients with the plan given to them by their physicians for control of hypertension. Because the literature reports a high correlation between income and level of education with compliance in other groups, these factors were also studied as …

Unusual Polymorphisms In Human Immunodeficiency Virus Type 1 Associated With Nonprogressive Infection, Louis Alexander, Emma Weiskopf, Thomas C. Greenough, Nathan C. Gaddis, Marcy C. Auerbach, Michael H. Malim, Stephen J. O'Brien, Bruce D. Walker, John L. Sullivan, Ronald C. Desrosiers

Biology Faculty Articles

Factors accounting for long-term nonprogression may include infection with an attenuated strain of human immunodeficiency virus type 1 (HIV-1), genetic polymorphisms in the host, and virus-specific immune responses. In this study, we examined eight individuals with nonprogressing or slowly progressing HIV-1 infection, none of whom were homozygous for host-specific polymorphisms (CCR5-Δ32, CCR2-64I, and SDF-1-3^'A) which have been associated with slower disease progression. HIV-1 was recovered from seven of the eight, and recovered virus was used for sequencing the full-length HIV-1 genome; full-length HIV-1 genome sequences from the eighth were determined following amplification of viral …

Ceftriaxone-Resistant Salmonella Infection Acquired By A Child From Cattle, Paul D. Fey, Thomas J. Safranek, Mark E. Rupp, Eileen F. Dunne, Efrain Ribot, Peter C. Iwen, Patricia A. Bradford, Frederick J. Angulo, Steven H. Hinrichs

Zoonotics and Wildlife Disease: Publications

Background
The emergence of resistance to antimicrobial agents within the salmonellae is a worldwide problem that has been associated with the use of antibiotics in livestock. Resistance to ceftriaxone and the fluoroquinolones, which are used to treat invasive salmonella infections, is rare in the United States. We analyzed the molecular characteristics of a ceftriaxone-resistant strain of Salmonella enterica serotype typhimurium isolated from a 12-year-old boy with fever, abdominal pain, and diarrhea.
Methods
We used pulsed-field gel electrophoresis and analysis of plasmids and β-lactamases to compare the ceftriaxone-resistant S. enterica serotype typhimurium from the child with four isolates of this strain …

Means To Achieve Sustained Release Of Synergistic Drugs By Conjugation, Paul Ashton, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hone Guo

Ophthalmology and Visual Science Faculty Patents

A codrug composition of at least two drug compounds covalently linked to one another via a labile bond to form a single codrug composition, or ionically linked to one another to form a single workings composition, and methods of use of the codrug for the treatment of various medical conditions. The codrug may be administered by itself or in the form of a bioerodible or nonbioerodible substance.

Fighting Aids With Holistic Weapons: An Integrated Approach, Tom Goodwin

Honors Theses

The current AIDS epidemic has changed the way we view the world as well as our society as a whole. Diseases have ravaged humanity since the dawn of time, so what makes AIDS so much different from every other disease encountered by man? One reason is its transmission method. We know that HIV passes from person to person via blood, semen, and vaginal secretions. Most people that suffer from this disease contract it during sex, during intravenous drug use, or during a blood transfusion. Early accounts of HIV disease occurred in minority groups, namely homosexual men. This may have bee …

Anti-Gag Cytolytic T Lymphocytes Specific For An Alternative Translational Reading Frame-Derived Epitope And Resistance Versus Susceptibility To Retrovirus-Induced Murine Aids In F1 Mice, Shawn-Marie Mayrand, Patricia A. Healy, Bruce E. Torbett, William R. Green

Dartmouth Scholarship

Murine AIDS (MAIDS) develops in susceptible mouse strains after infection with the LP-BM5 murine leukemia virus complex that contains causative defective, and ecotropic helper, retroviruses. We previously demonstrated that the MAIDSresistant H-2d strains BALB/cByJ and C57BL/KsJ generate MHC class I (Kd ) restricted virus-specific CD81 cytolytic T lymphocytes (CTLs) that lyse cells expressing either defective or ecotropic gag proteins. In contrast, the congenic BALB.B and closely related C57BL/6J MAIDS-susceptible H-2b strains were unable to serve as a source of gag-specific CTLs (Schwarz and Green, 1994), suggesting that anti-gag CTLs might provide a basis for resistance to MAIDS. Although its susceptibility …

Ada News - 04/03/2000, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Com Outlook April 2000, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Yale Nursing Matters Spring 2000 Issue 2 Volume 1, Yale University School Of Nursing

Yale School of Nursing Alumni Newsletters and Magazines

Please contact the Medical Historical Library if you need a higher resolution version.

Chironian Spring/Summer 2000, New York Medical College

The Chironian

No abstract provided.

Effect Of Chlamydia Trachomatis Infection And Subsequent Tnfa Secretion On Apoptosis In The Murine Genital Tract, Jean-Luc Perfettini, Toni Darville, Gabriel Gachelin, Philippe Souque, Michel Huerre, Alice Dautry-Varsat, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

The pathology observed during Chlamydia infection is due initially to localized tissue damage caused by the infection itself, followed by deleterious host inflammatory responses that lead to permanent scarring. We have recently reported that the infection byChlamydia in vitro results in apoptosis of epithelial cells and macrophages and that infected monocytes secrete the proinflammatory cytokine interleukin-1β. At the same time, proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α) can also trigger apoptosis of susceptible cells. To study the possible relationship between Chlamydia trachomatis infection and apoptosis in vivo, we used the terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling technique to …

Cytokines And The Anorexia Of Infection: Potential Mechanisms And Treatments, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Anorexia during infection is thought to be mediated by immunoregulatory cytokines such as interleukins 1 and 6 and tumor necrosis factor. This article reviews the potential mechanisms of action by which these cytokines are thought to suppress food intake during infection and examines the proposition that blocking of cytokine activity might be one approach to improving food intake of the infected host.

Medical And Social Diseases: Can The Former Moderate The Latter?, Ibpp Editor

International Bulletin of Political Psychology

This article describes how medical disease may moderate social disease in an era of globalization.

Ada News - 03/20/2000, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Genetic Resistance To Experimental Infection With In Red Deer (Cervus Elaphus), Colin G. Mackintosh, Tariq Qureshi, Ken Waldrup, Robert E. Labes, Ken G. Dodds, J. Frank T. Griffin

Michigan Bovine Tuberculosis Bibliography and Database

Tuberculosis (Tb) caused by Mycobacterium bovis is a worldwide threat to livestock and humans. One control strategy is to breed livestock that are more resistant to Mycobacterium bovis. In a 3-year heritability study 6 farmed red deer stags were selected from 39 on the basis of their differing responses to experimental challenge via the tonsillar sac with approximately 500 CFU of M. bovis. Two stags remained uninfected, two were moderately affected, and two developed serious spreading Tb. Seventy offspring, bred from these six stags by artificial insemination using stored semen, were similarly challenged with M. bovis …

Virus-Induced Neuronal Apoptosis Blocked By The Herpes Simplex Virus Latency-Associated Transcript, Guey-Chuen Perng, Clinton J. Jones, Janice Ciacci-Zanella, Melissa Stone, Gail A. Henderson, Ada Yukht, Susan M. Slanina, Florence M. Hofman, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler

School of Veterinary and Biomedical Sciences: Faculty Publications

Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT^- virus but not with LAT⁺ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

A Mycobacterium Ulcerans Toxin, Mycolactone, Causes Apoptosis In Guinea Pig Ulcers And Tissue Culture Cells, Kathleen M. George, Lisa Pascopella, Diane M. Welty, P. L. C. Small

Public and Community Health Sciences Faculty Publications

Mycobacterium ulcerans is the causative agent of Buruli ulcer, a tropical ulcerative skin disease. One of the most intriguing aspects of this disease is the presence of extensive tissue damage in the absence of an acute inflammatory response. We recently purified and characterized a macrolide toxin, mycolactone, from M. ulcerans. Injection of this molecule into guinea pig skin reproduced cell death and lack of acute inflammatory response similar to that seen following the injection of viable bacteria. We also showed that mycolactone causes a cytopathic effect on mouse fibroblast L929 cells that is characterized by cytoskeletal rearrangements and growth arrest …

Bulletin 4394 - Exotic Diseases - Sheep And Goats, Agriculture Western Australia

Bulletins 4000 -

An exotic disease is a disease which does not occur in Australia.

If an exotic disease did occur in Australia it would cause production losses, stock deaths and stop exports of primary production. When export markets are lost they can only be re-established once it is proven the disease is eradicated. Some exotic diseases may be transmitted to humans

Integronlike Structures In Campylobacter Spp. Of Human And Animal Origin, Brigid Lucey, D. Crowley, P. Moloney, B. Cryan, M. Daly, F. O'Halloran, E. J. Threlfall, S. Fanning

Department of Biological Sciences Publications

Resistance to antimicrobial agents used to treat severe Campylobacter spp. gastroenteritis is increasing worldwide. We assessed the antimicrobial resistance patterns of Campylobacter spp. isolates of human and animal origin. More than half (n = 32) were resistant to sulphonamide, a feature known to be associated with the presence of integrons. Analysis of these integrons will further our understanding of Campylobacter spp. epidemiology.

Naturally Occurring Tap-Dependent Specific T-Cell Tolerance For A Variant Of An Immunodominant Retroviral Cytotoxic T-Lymphocyte Epitope, Victor Kim, Jonathan W. Yewdell, William R. Green

Dartmouth Scholarship

Upon immunization and restimulation with tumors induced by the endogenous AKR/Gross murine leukemia virus (MuLV), C57BL/6 mice generate vigorous H-2K(b)-restricted cytotoxic T-lymphocyte (CTL) responses to a determinant (KSPWFTTL) derived from the p15E transmembrane portion of the viral envelope glycoprotein. By contrast, the highly homologous determinant RSPWFTTL, expressed by tumor cells induced by Friend/Moloney/Rauscher (FMR) MuLV, is not immunogenic, even when presented to the immune system as vaccinia virus-encoded cytosolic or endoplasmic reticulum (ER)-targeted minigene products. Such minigene products are usually highly immunogenic since they bypass the need for cells to liberate the peptide or transport the peptide into the ER …

Information Interface - Volume 28, Issue 1 - January/February 2000, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

Sulfa Or Sulfone Prophylaxis And Geographic Region Predict Mutations In The Pneumocystis Carinii Dihydropteroate Synthase Gene, Laurence Huang, Charles B. Beard, Jennifer Creasman, Deborah A. Levy, Jeffrey S. Duchin, Sherline Lee, Norman Pieniazek, Jane L. Carter, Carlos Del Rio, David Rimland, Thomas R. Navin

Journal Articles: Epidemiology

To determine factors associated with mutations in the Pneumocystis carinii dihydropteroate synthase (DHPS) gene, a prospective study of human immunodeficiency virus (HIV)-infected patients with confirmed P. carinii pneumonia was conducted in Atlanta, Seattle, and San Francisco. Clinical information was obtained from patient interview and chart abstraction. DHPS genotype was determined from DNA sequencing. Overall, 76 (68.5%) of 111 patients had a mutant DHPS genotype, including 22 (81.5%) of 27 patients from San Francisco. In multivariate analysis, sulfa or sulfone prophylaxis and study site were independent predictors of a mutant genotype. Fourteen (53.8%) of 26 patients who were newly diagnosed with …

The Sequential Schedule For Poliovirus Immunization: Factors Associated With Its Adoption By Primary Care Providers, Melissa Sharyn Ellis

Yale Medicine Thesis Digital Library

No abstract provided.

Ada Code Of Ethics (January 2000), American Dental Association

Code of Ethics

The ADA Code of Ethics has three main components: The Principles of Ethics, the Code of Professional Conduct and the Advisory Opinions. Contents may also include: Amendment to ADA Principles of Ethics and Code of Professional Conduct and Insert for the ADA Principles of Ethics and Code of Professional Conduct. The most current issue is available on the ADA’s website.