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Neuroanatomical And Neurochemical Effects Of Prolonged Social Isolation In Adult Mice, Vibol Heng, Michael Zigmond, Richard Jay Smeyne

Department of Neuroscience Faculty Papers

INTRODUCTION: As social animals, our health depends in part on interactions with other human beings. Yet millions suffer from chronic social isolation, including those in nursing/assisted living facilities, people experiencing chronic loneliness as well as those in enforced isolation within our criminal justice system. While many historical studies have examined the effects of early isolation on the brain, few have examined its effects when this condition begins in adulthood. Here, we developed a model of adult isolation using mice (C57BL/6J) born and raised in an enriched environment.

METHODS: From birth until 4 months of age C57BL/6J mice were raised in …

Activation Of The Renin–Angiotensin–Aldosterone System Is Attenuated In Hypertensive Compared With Normotensive Pregnancy, Robin C. Shoemaker, Marko Poglitsch, Hong Huang, Katherine Vignes, Aarthi Srinivasan, Cynthia Cockerham-Morris, Aric Schadler, John Anthony Bauer, John O'Brien

UK CARES Faculty Publications

Hypertension during pregnancy increases the risk of adverse maternal and fetal outcomes, but the mechanisms of pregnancy hypertension are not precisely understood. Elevated plasma renin activity and aldosterone concentrations play an important role in the normal physiologic adaptation to pregnancy. These effectors are reduced in patients with pregnancy hypertension, creating an opportunity to define the features of the renin–angiotensin–aldosterone system (RAAS) that are characteristic of this disorder. In the current study, we used a novel LC-MS/MS-based methodology to develop comprehensive profiles of RAAS peptides and effectors over gestation in a cohort of 74 pregnant women followed prospectively for the development …

The Role Of The Women's Organization Of Nahdlatul Ulama (Nu) In Efforts To Control Cigarette Consumption In Indonesia, Salsabila Nadya, Isranalita Madelif Sihombing

Cities and Urban Development Journal

Background: The protection of the nation's next generation from the dangers of smoking cannot be separated from the role of women/mothers as educators and as influencers in creating a safe and comfortable environment from exposure to cigarette smoke for children to grow and develop healthily.

Aims: To analyze the role of the Nahdlatul Ulama (NU) women's organization, namely NU Young Women's Organization (Fatayat NU) and NU Female Student Association (IPPNU) in efforts to control tobacco in Indonesia.

Methods: This research is descriptive research with a method of collecting data on the results of activities owned by the Center for Social …

Survival With Axicabtagene Ciloleucel In Large B-Cell Lymphoma, Jason R Westin, Armin Ghobadi, Et Al.

2020-Current year OA Pubs

BACKGROUND: In an analysis of the primary outcome of this phase 3 trial, patients with early relapsed or refractory large B-cell lymphoma who received axicabtagene ciloleucel (axi-cel), an autologous anti-CD19 chimeric antigen receptor T-cell therapy, as second-line treatment had significantly longer event-free survival than those who received standard care. Data were needed on longer-term outcomes.

METHODS: In this trial, we randomly assigned patients with early relapsed or refractory large B-cell lymphoma in a 1:1 ratio to receive either axi-cel or standard care (two to three cycles of chemoimmunotherapy followed by high-dose chemotherapy with autologous stem-cell transplantation in patients who had …

Etiologies And Predictors Of 30-Day Readmission In Heart Failure: An Updated Analysis, Akhil Jain, Shilpkumar Arora, Viral Patel, Maharshi Raval, Karnav Modi, Nirav Arora, Rupak Desai, Behnam Bozorgnia, Raphael Bonita

Einstein Health Papers

BACKGROUND AND OBJECTIVES: Readmissions in heart failure (HF), historically reported as 20%, contribute to significant patient morbidity and high financial cost to the healthcare system. The changing population landscape and risk factor dynamics mandate periodic epidemiologic reassessment of HF readmissions.

METHODS: National Readmission Database (NRD, 2019) was used to identify HF-related hospitalizations and evaluated for demographic, admission characteristics, and comorbidity differences between patients readmitted vs. those not readmitted at 30-days. Causes of readmission and predictors of all-cause, HF-specific, and non-HF-related readmissions were analyzed.

RESULTS: Of 48,971 HF patients, the readmitted cohort was younger (mean 67.4 vs. 68.9 years, p≤0.001), had …

The Sanitary Lens: A Study Of 19th Century Public Health In British Colonial India And Australia, Josephine Cannistra

University Honors Theses

Specific colonial processes informed highly distinct policies of public health and sanitation in colonial India and Australia. Their distinctions and lasting legacies are obscured when they are uncritically lumped together within the British Empire. The 19th century was a period of great change throughout India and Australia. It was also a period of dramatic change in general understandings of sanitation and health. This paper examines colonial India and Australia through the lens of sanitation and medicine as it was understood and practiced in British spheres of influence. A comparative approach to these histories and this past sheds light on how …

Postoperative Radiotherapy And Facial Nerve Outcomes Following Nerve Repair: A Systematic Review, Hannah L. Kenny, Rachel H. Jonas, Samuel L. Oyer

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

OBJECTIVE: To compare outcomes of facial nerve repair or grafting following facial nerve-sacrificing procedures among patients treated with and without postoperative radiotherapy (RT).

DATA SOURCES: PubMed, OVID, Conference Papers Index, Cochrane Library, ClinicalTrials.gov.

REVIEW METHODS: Databases were searched using terms including "facial nerve," "graft," "repair," and "radiotherapy." Abstracts mentioning facial nerve repair and evaluation of facial nerve function were included for full-text review. Studies that utilized the House-Brackmann or similar validated scale for evaluation of postoperative facial nerve function were selected for review. All identified studies were included in a pooled t test analysis.

RESULTS: Twelve studies with 142 patients …

Health Disparities Within Rural Communities In The Southern Region Of The United States, D’Angelo Stokes, Jordan Howard, Terrence Mchugh, Nicholas Bohannon, Emeka Ikeakanam, Evan Curry, Jason Walker

Research Day

Intro:

Historical studies have shown that health disparities exist between urban and rural communities, however additional disparities are also known to exist within rural communities as well. These include health disparities between races, ethnicities, and socioeconomic statuses, among others. While the disparities between urban and rural communities have been researched and described more extensively, there is a paucity of information available about the disparities that exist within rural communities. Our goal in this research initiative was to characterize the disparities that exist within rural communities by examining the findings of several publications that sought to describe this phenomenon in the …

Trust In Southern Nevada Health District By The Southern Nevada Population During The Covid-19 Pandemic, Edom Gelaw

UNLV Theses, Dissertations, Professional Papers, and Capstones

While various studies worldwide investigated trust in relation to health care, government and compliance with public health guidelines, literature remains scarce in relation to the Southern Nevada Health District (SNHD), its population and the services the organization offered during the COVID-19 pandemic. This study helps fill this gap and serves as a foundation for future research and a guide for service evaluations and improvements at SNHD. As trust towards local health districts by the community they serve remains an important component of public health for collaborative work, SNHD saw the need for evaluating trust by its population based on the …

Reflections On The Use Of Patient Records: Privacy, Ethics, And Reparations In The History Of Psychiatry, Jonathan Sadowsky

Faculty Scholarship

One of the most common questions we get asked as historians of psychiatry is “do you have access to patient records?” Why are people so fascinated with the psychiatric patient record? Do people assume they are or should be available? Does access to the patient record actually tell us anything new about the history of psychiatry? And if we did have them, what can, or should we do with them? In the push to both decolonize and personalize the history of psychiatry, as well as make some kind of account or reparation for past mistakes, how can we proceed in …

Management Of Anxiety And Depression In Post Coronary Artery Bypass Graft Surgery, Mansour Jannati, Amir Aslani

Journal of Mind and Medical Sciences

Depression and anxiety are common events in 30-40 percent of post coronary artery bypass graft (CABG) surgery patients. Depression symptoms in patients with CAD are expected to be significantly more, comparing the public incidence rate. Impaired remedy after coronary artery events may partly be attributed to depression and anxiety. If anxiety continues, it may lead to elevate metabolism and oxygen consuming. High level of anxiety increases the pain sensation in post CABG patients. This paper aimed to review results and findings of previous studies in the field of anxiety and depression management of post coronary artery bypass graft surgery. Up …

Therapeutic Effects Of Medicinal Mushrooms On Gastric, Breast, And Colorectal Cancer: A Scoping Review., Amit Dan, Robyn Swain, Seigna Belonce, Robin J. Jacobs

HPD Articles

Cancer is the leading cause of mortality globally. With anticancer medications causing severe adverse effects, understanding the role of alternative and efficacious anticancer treatments with minimal or no side effects can be beneficial. Edible mushrooms have been associated with certain health benefits and exhibit a broad range of pharmacological activities, including anti-inflammatory and immunomodulating activities. The anticancer potential of different mushrooms is now being tested. The goal of this scoping review was to discuss the most recent and available evidence on the therapeutic uses of medicinal mushrooms in cancer treatment, specifically those cancers with some of the highest mortality rates …

Best Practices For Improving Blended Learning In Nigeria: Critical Reflections On The Breast Cancer Clinical Pathway Development Course, Peace I. Egharevba, Kelechi Eguzo, Enyichukwu M. Anya, Nuhu Tumba, Kingsley Nnah, Chukwuemeka Oluoha, Precious Mbaraonye

Journal of Graduate Education Research

Although cancer clinical pathways (CPs) are standardized care plans for the treatment of specific cancers, they are not commonly used in Nigerian hospitals. Many Nigerian clinicians do not have the requisite skill for developing and implementing the use of CPs. Critical reflections provide an important perspective in the philosophy, design, implementation, and outcome of interventions. This paper critically reflects on the design and implementation of a multidisciplinary, blended learning (i.e. online and in-person) course which sought to improve the competence of local doctors, nurses, and allied students in developing clinical pathways. Reflective feedback was obtained from a mix of project …

Li-Rads: Looking Back, Looking Forward, Victoria Chernyak, Kathryn J Fowler, Richard K G Do, Aya Kamaya, Yuko Kono, An Tang, Donald G. Mitchell, Jeffrey Weinreb, Cynthia S Santillan, Claude B Sirlin

Department of Radiology Faculty Papers

Since its initial release in 2011, the Liver Imaging Reporting and Data System (LI-RADS) has evolved and expanded in scope. It started as a single algorithm for hepatocellular carcinoma (HCC) diagnosis with CT or MRI with extracellular contrast agents and has grown into a multialgorithm network covering all major liver imaging modalities and contexts of use. Furthermore, it has developed its own lexicon, report templates, and supplementary materials. This article highlights the major achievements of LI-RADS in the past 11 years, including adoption in clinical care and research across the globe, and complete unification of HCC diagnostic systems in the …

The Numbers Don’T Lie: A Quantitative Examination Of Trauma Outcomes Among Black Homeless Women, Lisa Marie Persad

Dissertations, Theses, and Capstone Projects

Based on the extensive levels of trauma exposure and the need to provide effective mental health treatment for homeless women and their families, this dissertation was conducted to better understand trauma-related psychological distress and associated mental health outcomes among Black homeless women. More specifically, this study’s researcher examined a national sample of homeless women using three theoretical frameworks (Social Determinants of Health, Critical Race Theory, and Intersectionality), conducting a secondary analysis of the Mental Health Client Level-2018 dataset from the Substance Abuse and Mental Health Services Administration (SAMHSA), and employing hierarchical logistic regression modeling to examine the relative impact of …

Effect Of Hiv And Antiretroviral Therapy Use On Body Weight Changes In A Cohort Of Us Veterans Living With And Without Hiv, Jose M Garcia, Yongquan Dong, Peter Richardson, Jennifer R Kramer, Christine M Hartman, Kathryn Royse, Donna L White, Elizabeth Y Chiao

Center for Medical Ethics and Health Policy Staff Publications

Objective: People living with HIV have high rates of obesity and obesity-related comorbidities. Our study sought to evaluate weight trajectory in a retrospective cohort of people living with HIV and matched HIV-negative veterans (controls) and to evaluate risk factors for weight gain.

Methods: This was a retrospective database analysis of data extracted from the VA Corporate Data Warehouse that included people living with HIV (n = 22 421) and age-matched HIV-negative controls (n = 63 072). The main outcomes were baseline body weight and weight change from baseline at 1, 2, and 5 years after diagnosis (baseline visit for controls). …

“Mind The Gap” - An Overview Of The Role Of The Extensions Community Healthcare Outcomes (Echo) Model In Enhancing Value In Health Care Delivery, Christina Kenny, Anushree Priyadarshini

Articles

The ECHO (Extensions Community Healthcare Outcomes) model of healthcare delivery has grown rapidly since its establishment and increased in popularity in recent years. This expansion has developed alongside the growing incidence of chronic diseases and the need to better manage them. The increasing uptake in ECHO has presented a requirement to assess its true value as healthcare costs are increasing globally, resulting in a growing demand by governments and policy makers to ensure chronic disease management strategies provide true value. Therefore, the aim of this review is to examine the impact that ECHO has on clinical practice and how such …

Psychology Or Religion? Bridge-Building In The Translation History Of The Tibetan Book Of The Dead, Erin Prophet

International Journal of Transpersonal Studies Advance Publication Archive

The Tibetan Book of the Dead is one of the most popular Eastern scriptures in the West, in part because it has been framed outside of religion, as a kind of psychology. And yet its translators have also used it to stake claims in the debate about the relationship between psychology and religion, generally Buddhism, but also Theosophy, a religious and philosophical system founded in 1875, which tried to unify all religions. The first major English translation of the Book of the Dead was published in 1927, by W. Y. Evans-Wentz, who was a Theosophist, with the assistance of Kazi …

Psychology Or Religion? Bridge-Building In The Translation History Of The Tibetan Book Of The Dead, Erin Prophet

International Journal of Transpersonal Studies

The Tibetan Book of the Dead is one of the most popular Eastern scriptures in the West, in part because it has been framed outside of religion, as a kind of psychology. And yet its translators have also used it to stake claims in the debate about the relationship between psychology and religion, generally Buddhism, but also Theosophy, a religious and philosophical system founded in 1875, which tried to unify all religions. The first major English translation of the Book of the Dead was published in 1927, by W. Y. Evans-Wentz, who was a Theosophist, with the assistance of Kazi …

Risk Factors And Outcomes Of Acute Kidney Injury Among Covid-19 Patients At A Tertiary Hospital In Kenya, Susan Cheruiyot

Master of Medicine in Family Medicine

Background: Corona Virus Disease 2019 (COVID-19), a novel infection caused by the SARS-Cov-2 virus, was declared a global pandemic on March 11, 2020. Three years later, 350,000 Kenyans had gotten the infection, with approximately 5,700 reported related deaths. Despite emerging research on the new virus, studies from the African continent on the impact of COVID-19 on the kidneys have been few. Early studies suggest that up to 75% of patients with COVID-19 have a derangement in their kidney function as evidenced by new onset proteinuria and hematuria. That said, the prevalence of acute kidney injury has varied greatly across populations, …

Associations Of Stress, Health Behaviors, And Obesity Among African American Immigrants, Wole David Akinsola

Walden Dissertations and Doctoral Studies

AbstractObesity has been identified as a predisposing factor that poses a serious threat for the development of chronic diseases and contributes to health disparities affecting both minority and vulnerable populations. Though previous studies reported the association of stress with health status and behavior, there is little or no research on the heterogeneity of obesity predictors in specific minority populations in the United States. The purpose of this study was to examine the predictors of obesity among adult African American immigrant populations in the United States. Studying obesity in this population may help policymakers tailor interventions that could reduce obesity prevalence. …

Comparison Of Machine Learning Methods For Classification Of Alexithymia In Individuals With And Without Autism From Eye-Tracking Data, Furkan Iigin, Megan A. Witherow, Khan M. Iftekharuddin

Electrical & Computer Engineering Faculty Publications

Alexithymia describes a psychological state where individuals struggle with feeling and expressing their emotions. Individuals with alexithymia may also have a more difficult time understanding the emotions of others and may express atypical attention to the eyes when recognizing emotions. This is known to affect individuals with Autism Spectrum Disorder (ASD) differently than neurotypical (NT) individuals. Using a public data set of eye-tracking data from seventy individuals with and without autism who have been assessed for alexithymia, we train multiple traditional machine learning models for alexithymia classification including support vector machines, logistic regression, decision trees, random forest, and multilayer perceptron. …

The Shortfalls Of Vulnerability Indexes For Public Health Decision-Making In The Face Of Emergent Crises: The Case Of Covid-19 Vaccine Uptake In Virginia, Lydia Cleveland Sa, Erika Frydenlund

VMASC Publications

Equitable and effective vaccine uptake is a key issue in addressing COVID-19. To achieve this, we must comprehensively characterize the context-specific socio-behavioral and structural determinants of vaccine uptake. However, to quickly focus public health interventions, state agencies and planners often rely on already existing indexes of "vulnerability." Many such "vulnerability indexes" exist and become benchmarks for targeting interventions in wide ranging scenarios, but they vary considerably in the factors and themes that they cover. Some are even uncritical of the use of the word "vulnerable," which should take on different meanings in different contexts. The objective of this study is …

A Comprehensive Examination Of The Evidence For Whole Of Diet Patterns In Parkinson's Disease: A Scoping Review, Joanna Rees, Jillian Ryan, Manja Laws, Amanda Devine

Research outputs 2022 to 2026

Both motor and non-motor symptoms of Parkinson’s disease (PD), a progressive neurological condition, have broad-ranging impacts on nutritional intake and dietary behaviour. Historically studies focused on individual dietary components, but evidence demonstrating ameliorative outcomes with whole-of-diet patterns such as Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) is emerging. These diets provide plenty of antioxidant rich fruits, vegetables, nuts, wholegrains and healthy fats. Paradoxically, the ketogenic diet, high fat and very low carbohydrate, is also proving to be beneficial. Within the PD community, it is well advertised that nutritional intake is associated with disease progression and symptom severity but understandably, …

Associations Of Stress, Health Behaviors, And Obesity Among African American Immigrants, Wole David Akinsola

Walden Dissertations and Doctoral Studies

AbstractObesity has been identified as a predisposing factor that poses a serious threat for the development of chronic diseases and contributes to health disparities affecting both minority and vulnerable populations. Though previous studies reported the association of stress with health status and behavior, there is little or no research on the heterogeneity of obesity predictors in specific minority populations in the United States. The purpose of this study was to examine the predictors of obesity among adult African American immigrant populations in the United States. Studying obesity in this population may help policymakers tailor interventions that could reduce obesity prevalence. …

Exploring Coloniality In Occupation-Based Education: Perspectives Of Ghanaian Occupational Therapists, Joana Nana Serwaa Akrofi, Amber M. Angell, Bright Gyamfi, Stefanie Bodison

Journal of Occupational Therapy Education

The history, scope, and practice of occupational therapy are taught in many parts of the world using western perspectives. Recently, occupational scientists have explored occupation-based education, including the extent to which occupation is central in occupational therapy programs and the mechanisms of teaching occupation. This study explores how western ideologies have influenced occupation-based education in Ghana by examining the teaching and practice of occupational therapy. We conducted a qualitative study using purposive sampling to recruit four participants from the first four cohorts of practitioners. Data was analyzed using thematic analysis. Our analysis yielded three main themes: Power, participants described power …

Gastrointestinal Organoids In The Study Of Viral Infections, J Thomas Gebert, Francesca Scribano, Kristen A Engevik, Jacob L Perry, Joseph M Hyser

Faculty, Staff and Students Publications

Viruses are among the most prevalent enteric pathogens. Although virologists historically relied on cell lines and animal models, human intestinal organoids (HIOs) continue to grow in popularity. HIOs are nontransformed, stem cell-derived, ex vivo cell cultures that maintain the cell type diversity of the intestinal epithelium. They offer higher throughput than standard animal models while more accurately mimicking the native tissue of infection than transformed cell lines. Here, we review recent literature that highlights virological advances facilitated by HIOs. We discuss the variations and limitations of HIOs, how HIOs have allowed for the cultivation of previously uncultivatable viruses, and how …

Review Of The Life And Legend Of Catterina Vizzani: Sexual Identity, Science And Sensationalism In Eighteenth-Century Italy And England, By Clorinda Donato, Ula E. Lukszo Klein

ABO: Interactive Journal for Women in the Arts, 1640–1830

Review of The Life and Legend of Catterina Vizzani: Sexual Identity, Science and Sensationalism in Eighteenth-Century Italy and England, by Clorinda Donato, written by Ula Lukszo Klein. Oxford University Studies in the Enlightenment, Liverpool University Press, 2020, 347 pp., 3 b/w images. ISBN: 978-1-789-62221-8

Outcomes In Patients With Poor-Risk Cytogenetics With Or Without Tp53 Mutations Treated With Venetoclax And Azacitidine, Daniel A Pollyea, Keith W Pratz, Andrew H Wei, Vinod Pullarkat, Brian A Jonas, Christian Recher, Sunil Babu, Andre C Schuh, Monique Dail, Yan Sun, Jalaja Potluri, Brenda Chyla, Courtney D Dinardo

Faculty, Staff and Student Publications

PURPOSE: To evaluate efficacy and safety of venetoclax + azacitidine in treatment-naïve patients with acute myeloid leukemia harboring poor-risk cytogenetics and TP53mut or TP53wt.

PATIENTS AND METHODS: We analyzed data from a phase III study (NCT02993523) comparing venetoclax (400 mg orally days 1-28) + azacitidine (75 mg/m2 days 1-7) or placebo + azacitidine, and from a phase Ib study (NCT02203773) of venetoclax + azacitidine. Patients were ineligible for intensive therapy. TP53 status was analyzed centrally; cytogenetic studies were performed locally.

RESULTS: Patients (n = 127) with poor-risk cytogenetics receiving venetoclax + azacitidine (TP53wt = 50; TP53mut = 54) were compared …

Appraising Rufaidah Al-Aslamia, First Muslim Nurse And Pioneer Of Islamic Nursing: Contributions And Legacy, Mustafa M. Bodrick, Mutlaq B. Almutairi, Fatma S. Alsolamy, Hisham M. Alfayyadh

Jurnal Keperawatan Indonesia

Global advancement in nursing is attributed mainly to western pioneers with negligible recognition of Rufaidah Al- Aslamia, who was the first Muslim nurse, and pioneer in Islamic nursing more than 1,400 years ago in Madinah (Medina, Saudi Arabia). She responded to the need for the provision of organized nursing care to injured soldiers in the Islamic battles during the time of Prophet Mohammed (Peace & Blessings Upon Him). The paucity of focus on Rufaidah Al-Aslamia triggered this scientific study to appraise her contributions and legacy as the pioneer of Islamic nursing. A qualitative, historical research inquiry was conducted using a …