Digital Commons Network^™

What Are The Specific Parameters Of Cold-Water Immersion On Its Positive Effects On Recovery And Sleep In The Physically Active Population?, Landyn L. James, Jay Albrecht, Dawn Hammerschmidt

Dissertations, Theses, and Projects

Cold-water immersion (CWI) is widely used in athletic and rehabilitative settings to enhance post‑exercise recovery, yet optimal treatment parameters remain inconsistent across clinical practice. Physically active individuals frequently seek recovery strategies that improve muscle function and sleep quality, creating a need to evaluate the evidence supporting specific CWI protocols. Focused Clinical Question: The purpose of this critically appraised topic (CAT) was to determine which temperature and duration parameters of CWI most effectively improve muscle recovery and sleep in physically active populations. A focused clinical question was developed using the PICO framework. Search Strategies: Systematic reviews and meta-analyses were identified through …

Investigating The Relationship Between Student Nurse Perceptions Of Faculty Caring Interactions And Their Reported Professional Quality Of Life, Lynette A. How

Dissertations, Theses, and Projects

Abstract

Burnout and compassion satisfaction in academic clinical contexts are critical dimensions of professional quality of life (ProQOL) in nursing education, yet their influence on student perceptions of faculty caring remains underexplored. Guided by Watson’s Theory of Human Caring and a social constructivist lens, this quantitative, cross-sectional correlational study examined relationships between nursing students’ self-reported professional quality of life and perceptions of faculty caring interactions. Data were collected from 207 prelicensure nursing students enrolled in practical, associate, and baccalaureate programs at two Midwestern institutions. Two validated instruments were employed: the Professional Quality of Life Scale – Short Version (Short ProQOL) …

A Critically Appraised Topic: Effectiveness Of Hydrogen-Rich Water Therapies In Reducing Inflammation, Bill Craig, Dawn Hammerschmidt, Jay Albrecht

Dissertations, Theses, and Projects

Inflammation is an important part of healing, but prolonged inflammation or inflammatory disease can cause excess pain and tissue damage. Hydrogen-rich water therapies have shown to have positive effects on this wide variety of conditions and may have a role in future therapeutic intervention for inflammatory conditions and acute injury care. Hydrogen is a commonly known element that has recently been the subject of scientific studies to analyze its beneficial properties when used as a therapeutic intervention. Hydrogen is physically the smallest element on the periodic table, and when two hydrogen atoms combine to form H2, it is known as …

Short-Term Bayesian Influenza Forecasting In A Hospital Environment Using A Linear Kalman Filter., Shankar Kaleeswaran Mani, Grzegorz A Rempala, Eben Kenah, Fernanda L Schumacher

Ambulatory and Primary Care Articles

Accurately forecasting the weekly number of influenza (flu) lab tests and positive cases is important for hospitals as they work to plan staffing, manage supplies, and provide timely patient care. In this paper, we describe a practical use of a Bayesian Kalman filter to forecast weekly flu tests and positives in a hospital setting. Using data from a large hospital system in Ohio, we show that this approach, which blends real-time hospital information with historical patterns, offers a dependable way to anticipate flu-related patient volume as far as four weeks ahead.

Development Of Small-Molecule Therapeutics Targeting Neurodegenerative Diseases And Oncology, Thomas Webster

Theses & Dissertations

Alzheimer’s disease (AD), Parkinson’s disease (PD), and colorectal cancer (CRC) remain significant clinical challenges requiring improved therapeutic strategies. This dissertation describes the design, synthesis, and pharmacological evaluation of structurally diverse small-molecule scaffolds targeting the sigma-1 receptor (S1R) for symptomatic modulation in AD, the dopamine D4 receptor (D4R) for management of L-DOPA–induced dyskinesia in PD, and claudin-1 for targeted intervention in CRC. Fused azabicyclic scaffolds were developed as S1R modulators, and systematic structure–activity relationship (SAR) studies identified key structural features governing receptor affinity, selectivity, metabolic stability, and central nervous system penetration. Optimized analogs demonstrated improved metabolic stability and favorable brain exposure, …

Exploring Weight Loss Medication Discourse: Mixed Methods Analysis Of Us-Based Facebook Posts, Elizabeth Dennard Mph, Katrina Makres Mph, Amrutha Alibilli, Vidur Jain, Anne Wang, Roger Abim-Karmon, Shaniece Criss Scd, Yulin Hswen Scd, Quynh C. Nguyen Phd, Alexandria Ratzki-Leewing Phd, Rozalina G. Mccoy Md, Thu T. Nguyen Scd

Health Sciences Publications

Background: Despite the documented clinical efficacy of weight loss medications, few large-scale mixed methods studies have captured the experiences of individuals taking these medications.

Objective: This study aims to examine dominant themes and public narratives about the perceived benefits, challenges, identity-based experiences, and the broader sociocultural framing of glucagon-like peptide-1 receptor agonist use on Facebook.

Methods: We used CrowdTangle to collect 2500 US-based Facebook posts from January 1, 2022, to May 31, 2024. Bidirectional encoder representations from transformers topic modeling was used to identify latent topics, followed by a qualitative thematic analysis.

Results: An analysis of 2500 Facebook posts revealed …

Pharmacogenomic-Guided Prescribing And Polypharmacy Across Age Groups In Obsessive-Compulsive Disorder: A Retrospective Study, Rachel A Schwartz, Nicolette Weisensel, Martin E Franklin, Madeline M Hartig, Maharaj Singh, Sreya Vadapalli

Faculty, Staff and Students Publications

Background: This study evaluated medication utilization in children, adolescents, and adults with obsessive-compulsive disorder (OCD), a chronic psychiatric condition characterized by intrusive thoughts and repetitive behaviors. Although first-line treatments include selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioral therapy (CBT), the heterogeneous biological underpinnings contribute to suboptimal outcomes, with 40-60% of individuals not responding to SSRIs. This complex phenotype often leads to psychotropic polypharmacy, which may be mitigated by incorporating combinatorial pharmacogenomic (PGx) testing into protocol-based care to identify potential gene-drug interactions.

Methods: A retrospective review was conducted of individuals with OCD aged 8 to 65 years who received either …

Cellular And Molecular Basis Of Pfcoronin Function In Artemisinin Resistance In Plasmodium Falciparum, Imran Ullah, Eva S Istvan, Et Al.

2020-Current year OA Pubs

Artemisinin combination therapies are central to malaria control, but their efficacy is threatened by the emergence of resistant Plasmodium falciparum strains. While the role of Pfkelch13 mutations is well established, mutations in Pfcoronin have also been implicated in treatment failure, revealing layers of resistance complexity. Here, we define the cellular mechanism of Pfcoronin‑mediated artemisinin resistance. PfCoronin interacts with PfActin and localizes to the parasite plasma membrane, the digestive vacuole membrane, and small vesicles containing host cell material. Mutations in PfCoronin disrupt its localization and perturb PfActin homeostasis, altering the distribution of ring‑stage morphologies, including a reduced proportion of parasites adopting …

Gut Microbiota Modulation Of Regulatory Dna Elements Revealed By Massively Parallel Functional Characterization, Chadmirah Zaratiana, Adheet Ganesh, Yang E Li, Et Al.

2020-Current year OA Pubs

Cis-regulatory elements (CREs) are central to dynamic gene regulation in hepatocytes, yet most functional annotations derive from in vitro models that poorly capture physiological regulation. We systematically profiled 109,386 human liver-derived CREs using massively parallel reporter assays in hepatocytes under matched in vitro and in vivo conditions. In vivo-active functional CREs (fCREs) were enriched for H3K27ac and chromatin accessibility and were regulated by diverse transcription factors in the human liver. We further demonstrate that gut microbiota-derived signals modulate fCRE activity and target gene expression in vivo, in part via the KEAP1/NFE2L2 antioxidant pathway. Specific microbial metabolites directly altered the activity …

Multi-Site Dms Probing Reveals Higher-Order Structure Of Rna-Protein Complexes In Living Cells, Anthony Hoang, Joshua Meehan, Ritwika Bose, David Mitchell, David H Price, Calla M Olson, Chase A Weidmann, Anthony M Mustoe

Faculty, Staff and Students Publications

Identifying tertiary structures and protein binding sites in RNA molecules remains a key challenge in RNA biology. We describe multi-site dimethyl sulfate (DMS)-mutational profiling (MaP) (msDMS-MaP), a strategy that enables simultaneous measurement of RNA secondary, tertiary, and quaternary structures via a single DMS chemical probing experiment. Optimized reverse transcription decodes typically invisible DMS N7-methylguanine (N7-G) modifications via a tautomer-induced mutational signature concurrent with N1 and N3 modifications. We show that N7-G reactivity reports on higher-order RNA structures, revealing key functional motifs such as pseudoknots and protein binding sites. Using msDMS-MaP, we find that E. coli ribosomal RNAs encode numerous independently …

Genetic Analysis Of The X-Linked Adrenoleukodystrophy Gene Abcd1 In Drosophila Uncovers A Conserved Phenotype, Joshua Manor, Sharayu V Jangam, Hyung-Lok Chung, Pranjali Bhagwat, Jonathan C Andrews, Hillary Chester, Shu Kondo, Saurabh Srivastav, Juan Botas, Ann B Moser, Suzette M Huguenin, Michael F Wangler

Duncan NRI Faculty and Staff Publications

X-linked adrenoleukodystrophy (X-ALD) is a progressive neurodegenerative disorder caused by a loss-of-function (LOF) mutation in the ATP-binding cassette subfamily D member 1 (ABCD1) gene, leading to the accumulation of very long-chain fatty acids (VLCFAs). This disorder exhibits striking heterogeneity; some male patients develop an early childhood neuroinflammatory demyelination disorder, while other patients, including adult males and most affected female carriers, experience a chronic progressive myelopathy. Adrenocortical failure is observed in almost all male patients, with the age of onset varying, sometimes being the first diagnostic finding. The gene underlying this spectrum of disease encodes an ATP-binding cassette (ABC) transporter that …

Staff Education To Improve Appointment Adherence In Outpatient Behavioral Health, Yvonne Joseph

Walden Dissertations and Doctoral Studies

No abstract provided.

Illness Perception, Depression, And Anxiety Among Middle-Aged Adults With End-Stage Chronic Kidney Disease, Zioleyda Soto

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education To Improve Fall Prevention In A Behavioral-Health Urgent Care Setting, May Nnenna Akalemeaku

Walden Dissertations and Doctoral Studies

No abstract provided.

A Transgenerational Analysis Of Factors Influencing Fertility Among Jamaican Men, Shanique Deniellia Essuman

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education On The Phq-9 Tool And Its Use, Claudine Agwi Mbah

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education To Improve Gad-7 Screening For Generalized Anxiety Disorder In Outpatient Behavioral Health Settings, Senami Olubunmi Edalere-Lukula

Walden Dissertations and Doctoral Studies

No abstract provided.

Fall-Prevention Program For A Long-Term Care Organization, Roslyn Y. Heyward

Walden Dissertations and Doctoral Studies

No abstract provided.

An Educational Module On Safe Nighttime Medication Administration In A Correctional Setting, Linda Asongtia Foleke

Walden Dissertations and Doctoral Studies

No abstract provided.

Mind Over Measure: The Role Of Self-Care Practices In Mitigating Mental Health Strain Among K-12 Educators, Jerry Burkett, Ryan Hulla

School Leadership Review

Teacher mental health is a critical concern in K-12 education, with high rates of burnout demanding effective protective strategies. This study investigated the relationship between five dimensions of teacher self-care (Physical, Psychological, Emotional, Spiritual, and Professional) and overall mental health outcomes, while specifically exploring differences between elementary (K-5) and high school (9-12) educators. A sample of K-12 teachers completed the Mental Health Inventory (MHI-5) and the Self-Care Inventory. Correlational analysis found that all five self-care dimensions were significantly and positively associated with mental health, with Professional Self-Care demonstrating the strongest link (r=.48, p

Screening Novel Secreted Proteins For Their Effects On Pancreatic Islet Function Using Qpcr-Based Gene Expression Analysis, Deepti Agarwal, Neha Mishra, Marcus Seldin

Cumberland Medica

Type 2 diabetes (T2D) involves progressive dysfunction of pancreatic β-cells and systemic insulin resistance. Although a handful of secreted factors acting on pancreatic islet have emerged as important therapeutic targets, many additional signaling processes remain unknown. The identification of such mediators can make a new contribution to the regulation of islet biology and serve as another approach for disease treatment. This study aimed to investigate whether three novel peptides could modulate islet-specific gene expression in vivo. Methods: Male C57BL/6J mice were injected with proteins then pancreatic tissues were collected six hours post-treatment. Total RNA was isolated, converted to cDNA, and …

Evaluating The Efficacy Of The Confusion Assessment Method For The Icu (Cam-Icu) In Reducing Length Of Stay Among Critically Ill Patients: A Scoping Review, John Simmons, Fay Nelson, Keith Hunt, Lindsey Waller, Tracy Mcclinton Dnp, Aprn, Agacnp-Bc, Hget-C, Ebp-C

Doctor of Nursing Practice Projects

Purpose/Background

Delirium is a prevalent complication among critically ill patients in intensive care units (ICUs), associated with increased mortality, prolonged hospital stays, and higher healthcare costs. The Confusion Assessment Method for the ICU (CAM-ICU) is a validated tool designed to aid in the early identification of delirium; however, systematic screening remains low among healthcare professionals. This scoping review aims to evaluate the efficacy of the CAM-ICU in identifying delirium and its potential impact on reducing ICU length of stay.

Method

            This scoping review began by establishing inclusion criteria to ensure the results were applicable to the researchers’ patient population, including …

Improving Engagement In Community Activities At Whitetail Springs Memory Care Community, Kylie T. Klavon

Public Health Capstone Projects

The purpose of this project, in collaboration with Whitetail Springs Memory Care Community, is to encourage consistent attendance and engagement among residents and staff in community activities, thereby enhancing residents’ well-being through greater meaningful engagement. This was done by assessing communication gaps between the clinical and activities teams, developing an educational infographic and scheduling template, and conducting an interactive presentation introducing these deliverables. This project was facilitated by observing current engagement and communication procedures at Whitetail Springs. After observations, brief interviews were conducted with the Life Enrichment Director and the Health Services Director to understand where each team needs support …

Developing A Comprehensive Resource Guide For Caregivers Within The Area Agency On Aging, Aiden R. Murphy

Public Health Capstone Projects

This project developed a new universal caregiver resource guide for caregivers within the Area Agency on Aging, in order to improve resource navigation and workflow efficiency. Resources were collected, verified, and organized into a new, streamlined guide via the ARIA chatbot, covering multiple needs. Caregiver resources were collected and verified by the capstone student and mentor, Michael Kroeker, and organized into a centralized knowledge base within the ARIA chatbot. A mixed methods evaluation was conducted utilizing a 5-point Likert scale with three quantitative questions and one open-ended qualitative question. The data was given to the SeniorLine staff, who wanted to …

Using Group Activities To Improve Engagement And Help Alleviate Loneliness Among Older Adults At Macedonia Face, Taylor Corcoran

Public Health Capstone Projects

Introduction: Social isolation and loneliness are increasing public health concerns due to their association with heightened risk for chronic disease and their disproportionate impact on Black older adults (BOA). This project was designed to develop, implement, and evaluate the effectiveness of culturally relevant, low-cost activities on engagement rates among older adults during unscheduled program periods at the Macedonia Family Community Enrichment Center (FACE).

Methods: This project used a mixed methods approach over a 4-week implementation period. Three activities were introduced by the student facilitator, including UNO!, Name That Tune (NTT), and coloring pages. Engagement was measured by comparing the …

Building Nurse Managers’ Knowledge And Confidence To Lead Clinical Ladder Success: A Theoretically Informed Educational Framework, Michelle Joann Chlebinski

Doctoral Projects

Background: Clinical Ladder Programs (CLPs) offer a structured pathway for nursing professional growth, fostering clinical excellence while improving nurse satisfaction and longterm retention. Although nurse managers play a pivotal role in facilitating the CLP, there is currently no comprehensive educational framework to enhance their knowledge and confidence in supporting clinical ladder advancement. Purpose: The aim of this DNP project is to develop implement, and evaluate an educational framework grounded in Benner’s Novice-to-Expert framework and Watson Caring Science® to enhance nurse managers' knowledge and confidence in leading nurses towards clinical ladder success. Methods: In a quasi-experimental study using a single-group, pre-post …

Medication-Assisted Treatment For Patients With Substance Use Disorder And Depression: A Scoping Review, Josiane Deguenon Bsn-Rn, Elisabeth Fritz Bsn-Rn, Jesse Jean Bsn-Rn, Tucker Mckinney Bsn-Rn, Laura Reed Dnp, Aprn, Fnp-Bc, Cne, Fnap

Doctor of Nursing Practice Projects

Purpose/Background

Substance use disorder (SUD) frequently co-occurs with depression and increases relapse risk and healthcare utilization. Although medication-assisted treatment (MAT) is an evidence-based intervention for SUD, outcomes for adults with co-occurring depression remain inconsistently reported due to variation in study designs, treatment settings, and measures. This scoping review examines evidence on MAT use among adults with co-occurring depression and SUD and summarized reported clinical and healthcare utilization outcomes.

Methods

From August 2023 to November 2025, a scoping literature review was conducted on PubMed/MEDLINE, CINAHL, and the Cochrane Library, using MeSH search terms and Boolean operators to link the concepts defined …

Dropping Into The Expressive Art Therapy: A Community Engagement Arts Based Project, Sydney C. Smith, Meg Chang

Expressive Therapies Theses

This community engagement capstone explores how expressive arts practices (EXAP) may complement surf-based programming by supporting reflection, empathy, and meaning-making among participants. Research has demonstrated that surf therapy can promote emotional well-being, resilience, and social connection through embodied engagement with the ocean and supportive community environments. Integrating expressive arts practices within surf-based programs may extend these benefits by providing opportunities for reflection, creative expression, and interpersonal exchange. Grounded in expressive arts therapy (EXAT) theory and arts-based research (ABR) paradigms, this project examines how creative expression can support relational and emotional experiences within surf therapy settings. Using an arts-informed community engagement …

Improving Hypertension Control Among Middle-Aged, Black, Female Patients Through Staff Education On Evidence-Based Joint National Committee Guidelines, Afolake Oyinlola

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education To Use Best Practices For Implementing And Utilizing The Digital Depression Screening Tool In An Outpatient Psychiatric Clinic, Robert James

Walden Dissertations and Doctoral Studies

No abstract provided.