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When Healing Becomes Horror: Medical Malpractice And Institutional Fear, Taryn Prater May 2026

When Healing Becomes Horror: Medical Malpractice And Institutional Fear, Taryn Prater

COD Library Student Research and Award Symposium

I studied medical malpractice through the lens of Monster Theory, examining how systemic failures, institutional silence, and cultural ideals shape harm in healthcare. I learned that malpractice is not only a legal issue, but a structural and ethical one, where fear and lack of transparency erode trust and impact both patients and providers.

Monstrous Medicine website

Faculty Sponsor: Professor Aleisha Balestri


Neuroplasticity And Hippocampal Impacts Associated With Obstructive Sleep Apnea, Rumaysa Aliniazee May 2026

Neuroplasticity And Hippocampal Impacts Associated With Obstructive Sleep Apnea, Rumaysa Aliniazee

COD Library Student Research and Award Symposium

A review on the implications of Obstructive Sleep Apnea (OSA) and Hippocampal Brain Health. It explores the role of sleep medicine, its effect on the hippocampus, its influence on cognitive function, and emphasizes the need for continued research and intervention to preserve cognitive health.

Faculty Sponsor:  Professor Felipe Armas


Boosting Psychological Well-Being In One Session: A Rapid Counseling Approach To Digital Detox And Music Therapy, Aryobimo Oentarto May 2026

Boosting Psychological Well-Being In One Session: A Rapid Counseling Approach To Digital Detox And Music Therapy, Aryobimo Oentarto

Buletin Konseling Inovatif

The rapid acceleration of technology has trapped modern youth in a digital connectivity paradox, where constant social media exposure triggers cognitive distortions and maladaptive behaviors that erode psychological well-being. This study evaluates the effectiveness of a Rapid Counseling approach integrated with Single-Session Music Therapy (RC-SSMT) in enhancing the psychological well-being of youth by breaking the cycle of digital addiction. Using a pre-test and post-test experimental design, the study focused on six youths (aged 15–17) at Church "X" in Jakarta who were identified as having low psychological well-being. The intervention combined a mandatory digital detox as a behavioral task with music …


Developing Antibodies Against Galectin-3 And Galectin-9 To Target Endometriosis, Ashleigh Burger, Noah Farnsworth, Jared J. Reisnouer, Cheyenne Vue May 2026

Developing Antibodies Against Galectin-3 And Galectin-9 To Target Endometriosis, Ashleigh Burger, Noah Farnsworth, Jared J. Reisnouer, Cheyenne Vue

2026 Symposium

Endometriosis is a disease characterized by pelvic pain and the formation of endometrial-like tissue on the outside of the uterine lining. This condition affects nearly 10% of women across the globe and confirming whether someone has endometriosis requires visualization in surgery. While the specific causes of this disease remain unclear, the over-expression of the Galectins 3 and 9 in ectopic endometrial tissues suggests a role in the development and maintenance of the condition. Monoclonal antibodies (mAbs) are highly specific proteins with potential as diagnostic or treatment tools. The goal of this study is to generate antibodies against Gal3 and Gal9. …


Parent Attitudes Toward Augmentative And Alternative Communication (Aac) In Children With Speech And Language Disorders, Megan N. Wells, Jane Grothaus May 2026

Parent Attitudes Toward Augmentative And Alternative Communication (Aac) In Children With Speech And Language Disorders, Megan N. Wells, Jane Grothaus

Undergraduate Research Journal

Augmentative and Alternative Communication (AAC) systems support individuals who experience difficulty communicating through spoken language. While research demonstrates that AAC can significantly improve communication outcomes, caregiver perceptions play a critical role in the successful implementation of these systems. The purpose of this study was to examine parent and caregiver attitudes toward AAC use among children with speech and language disorders. A fifteen-question online survey was distributed to caregivers of children currently using AAC systems. Responses from caregivers (n = 17) were analyzed using descriptive statistics and thematic analysis of open-ended responses. Results indicated that most caregivers reported improvements in their …


Investigating The Clinical Relevance Of A Modified 10 Meter Walk Test For Physical Therapists In The Treatment Of Acute Stroke Populations: Insights From A Case Series, Sarah Rowe, Gwen Juha, Todd E. Davenport, Joy Williams May 2026

Investigating The Clinical Relevance Of A Modified 10 Meter Walk Test For Physical Therapists In The Treatment Of Acute Stroke Populations: Insights From A Case Series, Sarah Rowe, Gwen Juha, Todd E. Davenport, Joy Williams

Pacific Journal of Health

The purpose of this case series is to examine the utility of a modified 10 Meter Walk Test (10MWT) for physical therapists treating acute stroke populations including discharge planning, equipment needs and clinical reasoning. Seven patients admitted within five days of various cerebrovascular accidents completed the 10MWT during inpatient treatment sessions with modifications such as assistive device use, modified instructions and physical assistance. Of these, two patients also completed a standardized 10MWT in the outpatient setting following discharge from inpatient services. Patients recommended versus actual discharge settings were recorded. Ultimately, those who were recommended for acute rehabilitation had the slowest …


Asymmetric Maxillary Molar Distalization And Guided Canine Eruption Using Temporary Anchorage Devices And Super-Elastic Niti Wire, Kah-Ying Yim, Huei-Mei Tsai, Yu-Ling Cheng, Ming-Jeaun Su, Yi-Min Liu May 2026

Asymmetric Maxillary Molar Distalization And Guided Canine Eruption Using Temporary Anchorage Devices And Super-Elastic Niti Wire, Kah-Ying Yim, Huei-Mei Tsai, Yu-Ling Cheng, Ming-Jeaun Su, Yi-Min Liu

Taiwanese Journal of Orthodontics

An adult female patient presented with a pronounced maxillary dental midline deviation and localized crowding in the upper right quadrant, particularly involving the canine and second molar. The maxillary right canine was buccally erupted and overlapped the lateral incisor and first premolar due to insufficient arch space and unfavorable root proximity. The mandibular arch exhibited mild anterior crowding with a flat curve of Spee. Orthodontic treatment was initiated using preadjusted fixed appliances. Extraction of the maxillary right third molar was performed to allow immediate sequential distalization of the maxillary right molars. A bypassed-canine main archwire in combination with a temporary …


Management Of Lower Incisor Protrusion In An Angle Class Iii Malocclusion Using Improved Super-Elastic Ti-Ni Alloy Wire, Jr-Wei Jian, Yu-Hsiang Chang, Yi-Mien Cheng, Ming-Han Cheng, Jian-Hong Yu May 2026

Management Of Lower Incisor Protrusion In An Angle Class Iii Malocclusion Using Improved Super-Elastic Ti-Ni Alloy Wire, Jr-Wei Jian, Yu-Hsiang Chang, Yi-Mien Cheng, Ming-Han Cheng, Jian-Hong Yu

Taiwanese Journal of Orthodontics

A 16-year-old adolescent female presented with the chief complaint of poor dental alignment and protrusion of the lower teeth. Clinical examination revealed Angle Class III malocclusion accompanied by lower anterior crowding and a protrusive lip profile involving both the upper and lower lips. Cephalometric analysis demonstrated a skeletal Class I relationship with a normal mandibular plane angle. To facilitate anterior retraction, four premolars (15, 24, 34, and 45) were extracted. Following extraction, Improved Super-elastic Ti-Ni alloy wire (ISW) was employed to relieve lower anterior crowding. Canine distalization and anterior retraction were subsequently performed. Elastic chains were used to assist midline …


Comparative Effectiveness Of Single Versus Two Miniscrews For Maxillary Incisor Intrusion In Gummy Smile: A Systematic Review And Meta-Analysis, Vaibhav Sunil Zanwar, Santosh Jetu Chavan, Jyoti Sunny Manchanda, Sakshi Santoshkumar Jain, Vedant S, Rishika Arya May 2026

Comparative Effectiveness Of Single Versus Two Miniscrews For Maxillary Incisor Intrusion In Gummy Smile: A Systematic Review And Meta-Analysis, Vaibhav Sunil Zanwar, Santosh Jetu Chavan, Jyoti Sunny Manchanda, Sakshi Santoshkumar Jain, Vedant S, Rishika Arya

Taiwanese Journal of Orthodontics

Background: Orthodontic intrusion of maxillary incisors is commonly used to treat gummy smiles in deep bite patients. The effectiveness of using one versus two miniscrews for this purpose remains debated. This systematic review and meta-analysis aimed to compare the dental effects of one versus two miniscrews for maxillary incisor intrusion.

Materials and Methods: A literature search was conducted across multiple databases for studies published up to December 31, 2024. Five studies (four randomized controlled trials and one non-randomized study) met the inclusion criteria. Risk of bias was assessed using the RoB 2 and ROBINS-I tools.

Results: Intrusion was greater in …


Correlation Between Maxillary Incisor Inclination And Buccopalatal Alveolar Bone Thickness Assessed By Cbct: A Retrospective Observational Study, Raee Korgaonkar, Nandini Kamat May 2026

Correlation Between Maxillary Incisor Inclination And Buccopalatal Alveolar Bone Thickness Assessed By Cbct: A Retrospective Observational Study, Raee Korgaonkar, Nandini Kamat

Taiwanese Journal of Orthodontics

Purpose: This retrospective study aimed to evaluate the correlation between buccal and palatal alveolar bone thickness and the degree of maxillary incisor inclination. The objective was to derive clinically relevant insights for orthodontic treatment planning and controlled tooth movement. Materials and Methods: Sixty-one maxillary central incisors from cone-beam computed tomography (CBCT) scans of thirty-four subjects were retrospectively evaluated and grouped as proclined, upright, and retroclined incisors. Buccal and palatal thicknesses of cortical and cancellous alveolar bone were measured at various levels of the incisor root. The correlation between bone thickness and incisor angulation was investigated using Spearman’s correlation test. Results: …


Evaluation Of Mandibular Buccal Shelf Bone Thickness And Height For Miniscrew Placement Using Cone-Beam Computed Tomography, Roji Shrestha, Rabindra Man Shrestha, Jyoti Dhakal, Sujita Shrestha May 2026

Evaluation Of Mandibular Buccal Shelf Bone Thickness And Height For Miniscrew Placement Using Cone-Beam Computed Tomography, Roji Shrestha, Rabindra Man Shrestha, Jyoti Dhakal, Sujita Shrestha

Taiwanese Journal of Orthodontics

Introduction: Buccal shelf area (BSA) is a recommended anatomic site for mini-screw insertion. Stability of miniscrew is determined by quantity of bone available in the region.

Objective: To determine bone thickness and height of BSA for optimum placement of miniscrew.

Materials and Methods: This cross-sectional observational study included 40 cone-beam computed tomography (CBCT) scans (23 males, 17 females) of patients aged 19-38 years. Patients were further divided into two age groups 19-28 years and 29-38 years. Measurements were made at 4 different sites: mandibular first molar mesial root (M6) and distal root (D6), second molar mesial root …


Preparing A Qualified Workforce To Support The Disability Community Through The Lend Interprofessional Learning Experience, Megan K. Roberts, Beth W. Degrace, Mark J. Fisher, Sandra H. Arnold May 2026

Preparing A Qualified Workforce To Support The Disability Community Through The Lend Interprofessional Learning Experience, Megan K. Roberts, Beth W. Degrace, Mark J. Fisher, Sandra H. Arnold

Developmental Disabilities Network Journal

Leadership and workforce preparation are vital roles of the nation’s academic institutions to advance health care services for the members of our communities. Leadership Education in Neurodevelopmental and other Related Disabilities (LEND) programs aim to prepare leaders in health care services and advocacy to improve systems and the quality of care and supports for the disability community, specifically children with developmental disabilities. LEND programs enhance standard health care pre-service training by providing interdisciplinary learning experiences for student trainees from a minimum of ten disciplines in 300 hours of learning activities over one academic year. An innovative feature of LEND programs …


Lungs And Beyond: Seizures As Presenting Symptom In A Patient With Mycobacterium Chimaera Infection, Samar Mehyar, Tripti Adhikari, Shweta Kambali, Harneet K. Ghumman, Avneet K. Ghumman, Parul Sud, Mehrshad Fathian Sabet, Elizabeth Mikhail, Sohrab Singh May 2026

Lungs And Beyond: Seizures As Presenting Symptom In A Patient With Mycobacterium Chimaera Infection, Samar Mehyar, Tripti Adhikari, Shweta Kambali, Harneet K. Ghumman, Avneet K. Ghumman, Parul Sud, Mehrshad Fathian Sabet, Elizabeth Mikhail, Sohrab Singh

Journal of Community Hospital Internal Medicine Perspectives

Mycobacterium chimaera is a slow-growing, non-tuberculous mycobacterium (NTM) that belongs to the Mycobacterium avium complex (MAC). It first emerged as a pathogen after being associated with infections in patients who underwent cardiothoracic surgery when patients were getting exposed to heater cooler units, especially those requiring extracorporeal membrane oxygenation (ECMO) or prosthetic valve placement. We report an atypical presentation of M. chimaera infection in a patient with COPD, but no prior history of cardiac surgery or immunosuppression.


Adrenal Crisis Induced-Seizures: A Case Report And Literature Review, Israel Umoh, Elizabeth Mikhail, Narjis Batool, Nosheen Hajra, Ibrahim Al-Sanouri May 2026

Adrenal Crisis Induced-Seizures: A Case Report And Literature Review, Israel Umoh, Elizabeth Mikhail, Narjis Batool, Nosheen Hajra, Ibrahim Al-Sanouri

Journal of Community Hospital Internal Medicine Perspectives

This case report underscores the critical interplay between adrenal crisis and seizure activity, emphasizing the importance of rapid recognition and management of this life-threatening condition. Adrenal crisis, characterized by severe hypotension and electrolyte disturbances, often manifests with nonspecific symptoms such as fatigue, nausea, and altered consciousness, which can obscure diagnosis, especially in pediatric and young adult populations. The report details a 21-year-old female with a complex endocrinologic background who developed seizures precipitated by an adrenal crisis triggered by gastroenteritis and compounded by medication noncompliance. Clinical findings included profound dehydration, electrolyte abnormalities, refractory hypotension, and low cortisol levels, which responded favorably …


The Hidden Crisis: A Rare Case Of Thyrotoxicosis In A Young Female, Mimicking Neuromuscular Disease, Ali Haider Awan, Seerat Riaz, Hafiz Muhammad Hashim Butt, Sajeela Riaz, Fnu Sameeha, Hilana Soliman Omar, Shafia Naeem, Abida Perveen, Jahanzeb Malik May 2026

The Hidden Crisis: A Rare Case Of Thyrotoxicosis In A Young Female, Mimicking Neuromuscular Disease, Ali Haider Awan, Seerat Riaz, Hafiz Muhammad Hashim Butt, Sajeela Riaz, Fnu Sameeha, Hilana Soliman Omar, Shafia Naeem, Abida Perveen, Jahanzeb Malik

Journal of Community Hospital Internal Medicine Perspectives

Thyrotoxic periodic paralysis (TPP) is a rare but life-threatening cause of acute flaccid paralysis associated with hypokalemia. Although more common in males and individuals of Asian descent, it may present atypically in young females and be easily misdiagnosed. We report a case of a 30-year-old female who presented with acute quadriparesis. Extensive neuromuscular evaluation initially pointed toward Guillain-Barré syndrome (GBS), but subsequent investigations revealed profound hypokalemia. Further workup confirmed thyrotoxicosis as the underlying cause. Prompt potassium replacement and initiation of antithyroid therapy led to complete clinical recovery. This case highlights the importance of considering both endocrine disorders and electrolyte disturbances, …


Staff Education On Central Line-Associated Bloodstream Infection Prevention Bundle Practices, Ngowari Warmate May 2026

Staff Education On Central Line-Associated Bloodstream Infection Prevention Bundle Practices, Ngowari Warmate

Walden Dissertations and Doctoral Studies

No abstract provided.


Evaluating The Effectiveness Of A Nurse-Initiated Post-Discharge Phone Call In The Prevention Of Hospital Readmissions For Type 2 Diabetes Mellitus, Sierra Kane May 2026

Evaluating The Effectiveness Of A Nurse-Initiated Post-Discharge Phone Call In The Prevention Of Hospital Readmissions For Type 2 Diabetes Mellitus, Sierra Kane

Doctoral Projects

Background: Hospital readmissions are widely recognized as a key metric of quality care, reinforced by Centers for Medicare and Medicaid (CMS) incentive programs (U.S. Centers for Medicare & Medicaid Services, 2025). Despite these incentives, achieving a meaningful reduction of readmissions remains a challenge, especially for chronic conditions such as type 2 diabetes mellitus (T2DM), where readmission is fueled by gaps in medication management, patient confidence in symptom management, and access to timely follow-up care. Purpose: Evaluate the impact of a nurse-initiated post-discharge telephone outreach, conducted at 48 hours, by the outpatient endocrinology clinic, on 7- and 30-day readmission rates for …


Clinical Practice Guideline To Reduce Lgbtq+ Disparities In Health Care, Angel Lb Ambrose May 2026

Clinical Practice Guideline To Reduce Lgbtq+ Disparities In Health Care, Angel Lb Ambrose

Walden Dissertations and Doctoral Studies

No abstract provided.


Establishing The Division Interprofessional Council By Using Magnet Principles, Warisara Manuel May 2026

Establishing The Division Interprofessional Council By Using Magnet Principles, Warisara Manuel

Walden Dissertations and Doctoral Studies

No abstract provided.


Educating Staff On The Use Of Generalized Anxiety Disorder-7 Screening Tool, Adetayo Adebayo May 2026

Educating Staff On The Use Of Generalized Anxiety Disorder-7 Screening Tool, Adetayo Adebayo

Walden Dissertations and Doctoral Studies

No abstract provided.


Pediatric Burns: Severity, First Aid, And When To Refer, Mike Smith, Pablo Aguayo May 2026

Pediatric Burns: Severity, First Aid, And When To Refer, Mike Smith, Pablo Aguayo

Pediatrics in Practice: A CME Podcast

This episode explains burn depth, TBSA estimation, and practical first aid that reduces complications—essential for pediatricians and ER providers who triage children with burns. Pablo Aguayo, MD (Children’s Mercy) walks through burn classification (superficial to fourth-degree), scald burns, and American Burn Association referral criteria. Keywords: pediatric burns, burn severity, burn first aid, scald injuries, TBSA, burn center referral. For more resources and show notes, visit the Pediatrics in Practice CME Podcast page and subscribe for updates.

Click here to stream the podcast episode.


Vaccines And Guns Data File, Alice Ann Crandall May 2026

Vaccines And Guns Data File, Alice Ann Crandall

ScholarsArchive Data

Three generation study of family health. The data sets associated with this submission examine attitudes about vaccines and guns across generations.


Accesstem: How Small Colleges Can Open Stem Pathways For Local High School Students, Dina D. Isakov May 2026

Accesstem: How Small Colleges Can Open Stem Pathways For Local High School Students, Dina D. Isakov

Program in Community Action (PICA)

This paper reflects my experience developing ACCESStem as part of the Program in Community Action (PICA) center at Connecticut College. ACCESStem is a community-engaged research project designed to create hands-on, lab-based STEM workshops for local high school students in New London. ACCESStem was built on the premise that even small liberal arts colleges can hold a meaningful impact on helping diversify the science workforce. Over the course of three years, this project took shape through my relationships with STEM faculty on campus and relationships with staff at the Holleran Center for Community Action. This paper works to begin contextualizing the …


Water-Soluble Fullerene Derivatives Mitigate Cranial Radiation-Induced Neuroinflammation And Cognitive Dysfunction, Naren Gundapaneni, Iona Hill, Lydia W T Cheung, Khadijeh Koushki, Alyssa Fausnaught, Phuoc Minh Quan Mai, Arjun Vasan, Prapannajeet Biswal, Ashutosh Tripathi, Anilkumar Pillai, Vijayasree V Giridharan, Tatiana Barichello, Yuri Mackeyev, Sunil Krishnan May 2026

Water-Soluble Fullerene Derivatives Mitigate Cranial Radiation-Induced Neuroinflammation And Cognitive Dysfunction, Naren Gundapaneni, Iona Hill, Lydia W T Cheung, Khadijeh Koushki, Alyssa Fausnaught, Phuoc Minh Quan Mai, Arjun Vasan, Prapannajeet Biswal, Ashutosh Tripathi, Anilkumar Pillai, Vijayasree V Giridharan, Tatiana Barichello, Yuri Mackeyev, Sunil Krishnan

Faculty, Staff and Student Publications

Radiotherapy is widely used to treat malignant and benign brain tumors. A major constraint, however, is the low tolerance of normal brain tissue to radiation. Cranial irradiation-induced injury manifests as inflammatory responses and neurodegeneration, which jointly contribute to progressive cognitive decline. These complications can restrict the delivery of optimal therapeutic doses, cause persistent neurological symptoms, and ultimately compromise quality of life. Thus, neuroprotective agents have emerged as a strategy to safeguard normal tissues from radiation-induced neurotoxicity. This study investigated the efficacy of a highly soluble [60]fullerene (C60) derivative, C60-ser, a carbon-based nanomaterial, to mitigate radiation-induced brain injury. Oral administration of …


H2ax C-Terminal Dipeptide Truncation: A Master Switch Of The Dna Damage Response, Faith M Joseph, Matthew V Holt, John M Jerome, Linda Zhang, Ashley G Boice, Patricia D Castro, Sofía I Aramburu, Ruhee Dere, Susan M Rosenberg, David R Rowley, Nicolas L Young May 2026

H2ax C-Terminal Dipeptide Truncation: A Master Switch Of The Dna Damage Response, Faith M Joseph, Matthew V Holt, John M Jerome, Linda Zhang, Ashley G Boice, Patricia D Castro, Sofía I Aramburu, Ruhee Dere, Susan M Rosenberg, David R Rowley, Nicolas L Young

Faculty, Staff and Students Publications

Phosphorylation of histone H2AX at serine 139 (γH2AX) by ATM/ATR kinases is a central marker of the DNA damage response (DDR), widely used to detect DNA double-strand breaks. However, the molecular basis for tissue- and context-specific variation in γH2AX signaling remains poorly defined. Here we discover a post-translational truncation of H2AX, catalyzed by lysine demethylase 4A (KDM4A), which removes two C-terminal amino acids critical for ATM/ATR-dependent phosphorylation. This truncation renders H2AX refractory to γH2AX formation, effectively bypassing canonical DDR signaling. Truncated H2AX accumulates in select cell lines, primary cells, solid tumors, and normal tissues. Genetic knockdown or pharmacologic inhibition of …


Natural History Of Ngly1 Deficiency: Motor Function & Clinical Features, Grace Morrison, Selina Dwight, Hal Landy, William F Mueller, Pam Ventola, Regina Deck, Becky Schweighardt, Matt Wilsey, Kevin J Lee, Bernhard Suter May 2026

Natural History Of Ngly1 Deficiency: Motor Function & Clinical Features, Grace Morrison, Selina Dwight, Hal Landy, William F Mueller, Pam Ventola, Regina Deck, Becky Schweighardt, Matt Wilsey, Kevin J Lee, Bernhard Suter

Faculty, Staff and Students Publications

N-glycanase 1 (NGLY1) Deficiency is an ultra-rare neurodevelopmental disorder caused by biallelic loss-of-function mutations in the NGLY1 gene, leading to severe impairments in neurocognitive and motor function abilities in the affected patient population. Its core clinical features include global developmental delay, hyperkinetic movement disorders, elevation of liver transaminases, (hypo)alacrima, and progressive sensorimotor neuropathy. Due to the range of phenotypes and severity within the confirmed patient population, ongoing characterization of the disease is critical. A prospective natural history study (NHS) was conducted to further elucidate disease phenotypes and examine any changes in neurocognitive or motor function over a one-year period. Fifteen …


Trauma-Informed Intake Standardization Equitable Approach, Ketura James May 2026

Trauma-Informed Intake Standardization Equitable Approach, Ketura James

Walden Dissertations and Doctoral Studies

No abstract provided.


Staff Education On Improving Primary Care Depression Screening With The Patient Health Questionnaire-9, Patience Amune May 2026

Staff Education On Improving Primary Care Depression Screening With The Patient Health Questionnaire-9, Patience Amune

Walden Dissertations and Doctoral Studies

No abstract provided.


Is2c2: A Cointelligent Platform For Mechanistic Discovery Of Disease Cellular Crosstalk, Jianting Sheng, Ju Young Ahn, Li Yang, Zhihao Wan, Shaohua Qi, Xiaohui Yu, Zhan Xu, Yuliang Cao, Matthew Vasquez, Amna Irfan, Yuanyuan Zhu, Hong Zhao, Zheng Yin, Ying Zhu, Yunfeng Ding, Alireza Faridar, Lin Wang, Fengshuo Liu, Hongxia Wang, Zhigang Ji, Dongxue Mao, Michael Chan, Daniel Kermany, Wenjuan Dong, Doo Yeon Kim, Xiang H-F Zhang, Stephen T C Wong May 2026

Is2c2: A Cointelligent Platform For Mechanistic Discovery Of Disease Cellular Crosstalk, Jianting Sheng, Ju Young Ahn, Li Yang, Zhihao Wan, Shaohua Qi, Xiaohui Yu, Zhan Xu, Yuliang Cao, Matthew Vasquez, Amna Irfan, Yuanyuan Zhu, Hong Zhao, Zheng Yin, Ying Zhu, Yunfeng Ding, Alireza Faridar, Lin Wang, Fengshuo Liu, Hongxia Wang, Zhigang Ji, Dongxue Mao, Michael Chan, Daniel Kermany, Wenjuan Dong, Doo Yeon Kim, Xiang H-F Zhang, Stephen T C Wong

Faculty, Staff and Students Publications

Large language models (LLMs) have demonstrated impressive capabilities in summarization, reasoning, and content generation, yet their inability to directly interpret large-scale omics data has limited their utility in data-driven hypothesis generation-particularly in mechanism discovery that demands the integration and interpretation of multimodal datasets, heterogeneous models, and deep domain expertise. Conversely, traditional computational algorithms excel at quantitative analysis of omics data but often rely heavily on labor-intensive, expert-driven interpretation to extract biologically meaningful insights. Here, we introduce (cointelligent single-cell spatial cell‒cell communication: iS2C2), a novel cointelligent platform that synergizes mathematically rigorous computational algorithms with the contextual reasoning capabilities of LLMs to …


Correction: Berezowski Et Al. Biomarkers In Renal Cell Carcinoma: A Systematic Review And Immunohistochemical Validation Study, Brett Berezowski, Robert Boothe, Billy Chaplin, Sharon J Del Vecchio, Zakariya Fares, Tyrone L R Humphries, Keng Lim Ng, Taylor Noonan, Hemamali Samaratunga, Aaron Urquhart, David A Vesey, Simon T Wood, Glenda C Gobe, Robert J Ellis May 2026

Correction: Berezowski Et Al. Biomarkers In Renal Cell Carcinoma: A Systematic Review And Immunohistochemical Validation Study, Brett Berezowski, Robert Boothe, Billy Chaplin, Sharon J Del Vecchio, Zakariya Fares, Tyrone L R Humphries, Keng Lim Ng, Taylor Noonan, Hemamali Samaratunga, Aaron Urquhart, David A Vesey, Simon T Wood, Glenda C Gobe, Robert J Ellis

Faculty, Staff and Student Publications

This corrects the article "Biomarkers in Renal Cell Carcinoma: A Systematic Review and Immunohistochemical Validation Study" in volume 17, 2588.