Digital Commons Network^™

Poly(Adp-Ribose) Polymerase Inhibitor Maintenance Therapy In Ovarian Cancer: A Single-Center Retrospective Study., Sydney Pence, Kayla Dyson, Kristen Waters, John O Elliott, Kellie Rath, Stuart Pierce, Amy Harper, Corinne Calo, Aine E Clements

OhioHealth Research Institute Articles

OBJECTIVE: To determine the effectiveness and tolerability of PARPi maintenance in a real-world patient population. Specifically, to assess duration of PARPi, the rate of secondary malignancies, rate of side effects, and survival.

METHODS: A retrospective review of patients with ovarian, fallopian tube, and primary peritoneal cancer at OhioHealth Riverside Methodist Hospital in Columbus, Ohio was performed. All patients diagnosed since March 2015 were reviewed for eligibility. Data was collected via EMR query and stored in REDCap. Charts were reviewed for multiple data points, including duration of PARPi use, side effects, secondary malignancies, survival, and recurrence. Data were reported descriptively with …

Longitudinal Changes In Cognition And Brain Imaging In Persons With Human Immunodeficiency Virus, James Kennedy, Sarah A Cooley, June Roman Fox, Kalen J Petersen, Elizabeth Westerhaus, Pat Reid, Linet Lopez, Beau M Ances

2020-Current year OA Pubs

BACKGROUND: As persons with human immunodeficiency virus (PWH) live longer, interactions between human immunodeficiency virus (HIV), aging, and structural brain integrity become increasingly vital for understanding cognitive disorders. This study analyzed the effects of aging, HIV serostatus, and viral load on cognition and brain volumes in a large cohort of persons without HIV (PWOH), PWH with undetectable virus (PWHU) (HIV RNA ≤50 copies/mL), and PWH with detectable virus (PHWD) (HIV RNA >50 copies/mL). Cross-sectional and longitudinal data were included.

METHODS: Cognitive composites (NPZ4) and brain volumes were obtained from 259 PWOH, 264 PWHU, and 84 PWHD with a total of …

Impact Of Travel Time To Health Facilities On Perinatal Outcomes: A Systematic Review With Narrative Synthesis And Meta-Analysis, Sanam Roder-Dewan, Marwa Ramadan, Paul Ouma, Alexander Manu, Emelda A. Okiro, Natalie Strobel, Bibian N. Robert, Emily Odipo, Peter M. Macharia, Anthony Danso-Appiah, David C. Goodman, Queen Dube, Gagan Gupta, Hema Magge, Karen Edmond

Research outputs 2022 to 2026

Background: Evidence-based global guidance on safe travel time for small or sick newborns who require transfer to health facilities after birth is lacking. A two-hour threshold is frequently cited in low- and middle-income countries (LMICs), while 30 minutes is commonly used in high-income countries (HICs). Although these thresholds are widely referenced, their empirical basis and consistency across levels of newborn care and journey types have not been systematically examined. This study synthesises the evidence linking travel time and perinatal outcomes. Methods: We conducted a systematic review with narrative synthesis and meta-analysis to assess the impact of travel time or distance …

Gut Dysbiosis And Microbial Metabolites In Atopic Dermatitis: Implications For Immune Regulation Along Gut-Skin Axis, Khushbakhat Alia, Hira Khan, Hamna Muzaffar, Nighat Perveen, Sara Alrashedi, Yusra Al Dhaheri, Yasir Waheed, Mohammed Tauqeer Alam, Muhammad Naseem, Khalid Muhammad

All Works

Atopic dermatitis (AD) is a multifactorial skin disorder characterized by immune dysregulation, impaired epidermal barrier, and strong microbial imbalance. Although genetic susceptibility and environmental triggers are established AD drivers, growing evidence highlights the gut skin axis as an important but underexplored AD pathogenesis factor. Gut microbiota dysbiosis, loss of short-chain fatty acid (SCFA)-producing bacteria, and altered metabolite profiles, such as tryptophan derivatives and secondary bile acids, have been linked to systemic immune imbalance and skin inflammation. However, the precise mechanism by which gut microbial alterations influence cutaneous immunity remains unclear. This review synthesizes recent advances from clinical and experimental studies …

Quadriceps Tendon Versus Patellar Tendon Autograft For Primary Acl Reconstruction: A Matched-Pairs Analysis At 3, 6, And 9 Months, Grant Gueller, Steven Higbie, Walter Lowe

Summer Research Program Abstracts

No abstract provided.

Harnessing Mechanobiology Of Resident Stem Cells To Refine Cell Based Therapeutics, Dakota R. Kamm

WUSM Theses and Dissertations – All Programs

Mesenchymal stem cells (MSCs) are resident cells residing with many adult tissues such as adipose tissue and bone marrow that have the potency for multiple lineage differentiation as well as the capacity to secrete a litany of beneficial factors to maintain homeostasis and promote tissue repair. Since 1995, MSCs have been used therapeutically to treat a variety of conditions from osteoarthritis to heart disease to muscle pathologies. Great leaps have been made in improving MSC-based therapies through optimization of culture methods and select enrichment of cellular subpopulations. More recently, the physical microenvironment of tissue in vivo and culture conditions in …

Multiple Intracranial Aneurysms: An International Consensus Statement, Stavropoula Tjoumakaris

Department of Neurosurgery Faculty Papers

Introduction: Multiple intracranial aneurysms (MIAs) pose diagnostic and therapeutic challenges, and widely used rupture-risk scores have not been validated for this subgroup. Research question: To develop expert-based recommendations for the diagnosis, rupture-risk assessment, treatment selection, and follow-up of patients with MIAs. Material and methods: A modified Delphi process was conducted. After topic generation from the literature, iterative questionnaires were administered anonymously online to invited experts. Consensus was prespecified as ≥70% agreement. Twenty-six of 35 invitees (74.3%) completed the survey. Results: Consensus identified the ruptured lesion in aneurysmal subarachnoid hemorrhage (aSAH) using computed tomographic angiography (CTA) and 3D rotational digital subtraction …

Associations Between Father–Mother Food Parenting Practices And Children’S Dietary Intake, Brian K. Lo, Natalie Grafft, Mariane Helen De Oliveira, Sebastien Haneuse, In Young Park, Alejandra Cantu-Aldana, Katherine W. Bauer, Rebekah Levine Coley, Jorge E. Chavarro, Kirsten K. Davison, Jess Haines

Human Genetics Publications

Objective: To examine whether the number of parents using high levels of structure or coercive control food parenting practices is associated with children’s dietary intake.

Design: Cross-sectional analysis of father–mother dyads from the Fathers & Families cohort study. Fathers and mothers independently reported their food parenting practices and child’s dietary intake. Multivariate logistic regression models estimated associations between the number of parents (0, 1 or 2) using high structure or coercive control practices and children’s intake of fruit, vegetables, fast food and sugar-sweetened beverages (SSB), adjusting for demographics and recruitment site.

Setting: United States

Participants: 474 father–mother dyads with a …

Quantification Of Sarm1 Nadase Activity In Human Peripheral Blood Mononuclear Cells, Lila F Dabill, Ivana R Shen, Jennifer M Brazill, Alicia Neiner, Yo Sasaki, Erica L Scheller

2020-Current year OA Pubs

SARM1 (sterile α and TIR motif-containing protein-1) is an NADase enzyme that serves as the central executioner of Wallerian axon degeneration. Given this, SARM1 is of high interest as a candidate therapeutic target, and SARM1 inhibitors are currently in clinical trials for treatment of neurodegeneration. Beyond neuroscience, emerging studies reveal that SARM1 may also drive aspects of bone fragility, liver pathology, adipose expansion, and insulin resistance in metabolic disease. However, we lack methods to quantify SARM1 activation in humans to better define patients at high risk of SARM1-mediated tissue damage. Unlike neurons, peripheral blood mononuclear cells (PBMCs) represent an easily …

Exploring Bidirectionality In Global Health Partnerships: Perspectives From U.S. Pediatric Residency Programs., Anik Patel, Pauline Kamau, Justus Simba, Ashley Combs, Adelaide Barnes, Kathy Ferrer, Heather Haq, Duncan K. Hau, Lee Morris, Brittany Murray, Amy Rule, Reena P. Tam, Lisa Umphrey, Megan S. Mchenry

Manuscripts, Articles, Book Chapters and Other Papers

Introduction Despite growing interest, little guidance exists to re-evaluate global health partnerships (GHPs) through promoting bidirectionality. This study aims to understand the perspectives of United States (U.S.) pediatric global health (GH) faculty on institutional bidirectional practices to inform future discussions with international collaborators. Methods An internally, iteratively developed REDCap-based online survey (REDCap, Vanderbilt University, Nashville, TN), by our diverse author group, collected qualitative data from January 18 to February 20, 2023. Free-text responses were reviewed and coded inductively, with findings framed to generate themes for subsequent engagement with international partners. Results Of the 88 U.S. programs that identify as having …

Subclinical Neuropsychiatric Trait Variation In Parents Of Children With Autism Spectrum Disorder: A Cohort Study, Lindsay J Mullin, Carolyn Lasch, Natasha Marrus, Et Al.

2020-Current year OA Pubs

BACKGROUND: Many neuropsychiatric conditions share overlapping features underpinned by shared genetics. In this study, we examined the co-aggregation of sub-threshold variation in neuropsychiatric phenotypes in biological parents of autistic children to provide insights into the intergenerational transmission of genetic liability for autism.

METHODS: Autistic, neuropsychiatric (i.e., anxiety, depression, ADHD), and cognitive traits were characterized in biological parents of children enrolled in a longitudinal developmental study: 189 families of autistic children and 100 families with no autistic children were included. Families were further characterized as having only one (simplex) or more than one (multiplex) autistic child. Maternal and paternal traits were …

Neurodiversity Among Nurses: Consequences For Wellbeing And Burnout, Megan Pohlmann

WUSM Theses and Dissertations – All Programs

Background/Introduction – Current research highlights three critical aspects of nurse wellbeing: the subjective personal perspective, multifaceted complexity, and variation across individuals. A particular gap in past research is a lack of understanding of how neurodivergence may impact nurses’ workplace wellbeing. Neurodiversity is the variation in human minds and neurocognitive functioning, and neurodivergence is the divergence from what society would consider the norm. Like wellbeing, it is difficult to capture, recognize, and define, which causes confusion among neurodivergent individuals and employers alike. With up to 20% of individuals displaying neurodivergent traits in the workplace, it is important to recognize that those …

Improving The Assessment And Treatment Of People With Low Back Pain, Kayla Krueger

WUSM Theses and Dissertations – All Programs

Low back pain (LBP) is a significant and continually growing public health problem. While some people recover from an initial episode, a proportion will develop chronic or recurrent LBP that limits their ability to perform daily functional activities. The variable and often function-limiting course of LBP underscores the clear need for improved methods of assessment and treatment. One way to improve the assessment and treatment of LBP is to develop a more comprehensive understanding of factors that contribute to LBP. In this dissertation, we investigated two categories of factors that may contribute to a person’s LBP: (1) spinal movement impairments …

Examining The Association Of Nurse Staffing Levels With Delayed Antibiotic And Insulin Administration: A Mixed Methods Study, Mikie Desyana Rachman

WUSM Theses and Dissertations – All Programs

Background: Recent reports indicated that medication errors contributed to 10% of preventable harm among hospitalized patients with over half occurring during the administration stage. Despite emerging research using EHR data to examine care processes and clinical outcomes, limited studies have integrated objective and subjective nursing staffing measures to evaluate how nursing staffing levels could be associated with delays in care delivery.

Method: A parallel convergent mixed-methods study was conducted in four adult medical-surgical units at a Midwestern Academic Medical Center from January 1 – March 31, 2025. Quantitative data of insulin and IV antibiotic administration records, laboratory results, and nurse …

Multiscale Modeling Of Chemoattractant-Guided Collective Cell Migration In The Drosophila Egg Chamber, Lara Scott, Bradford E. Peercy, Meghan Kwon, Michelle Starz-Gaiano

Biology and Medicine Through Mathematics Conference

No abstract provided.

Impact Of Innate, Adaptive, And Cellular Immunity On Viral Reproductive Cycle: A Stochastic Extinction Analysis, Rahnuma Islam, David Swigon

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Epidemic Dynamics With Renewal Processes And General Lifetime Distributions, Divine Wanduku, Divine Wanduku

Biology and Medicine Through Mathematics Conference

No abstract provided.

Stochastic Invasion And Extinction In Environmentally Transmitted Diseases, Mahmudul Bari Hridoy, Lauren M. Childs

Biology and Medicine Through Mathematics Conference

No abstract provided.

The Making Of An Extremist: How Do We Become Someone Else’S Nightmare?, María Paula Morales

The Confluence

This article explores how ordinary people can be pulled into extremist movements and what psychological forces drive that process. It looks at three perspectives: social identity theory, which explains how group belonging shapes behavior, identity development, which shows how people searching for meaning may find it in extremist causes; and social neuroscience, which connects radicalization to brain activity linked to fear, loyalty, and moral judgement. Together, these approaches show that radicalization is not simply about ideology but about identity, emotion, and belonging. By understanding these dynamics, we can find better ways to prevent extremism and promote healthier, more inclusive communities.

A New Framework For Studying Transient Reactivity In Two-Dimensional Linear Systems., Mary Lou Zeeman, Alanna Haslam-Hyde, James Broda

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Psychological And Demographic Predictors Of Analog Astronaut Mission Participation, Christian Yeara Herrero, Frányerson R. López Ochoa, Mackenzie Thomas, Phoebe Fleshman

Student Research Symposium (SRS)

As plans accelerate to send humans into orbit and to other celestial bodies, whether to lunar outposts, Mars bases, or commercial space stations, it becomes increasingly important to understand how to maintain healthy, cohesive, and productive crews in confined, isolated environments. A practical way to study human adaptation to these conditions is through analog astronaut missions on Earth. Although imperfect, these facilities provide the closest Earth-based simulation of space mission conditions. Currently, over ten analog research centers are operating worldwide, including NASA’s Human Exploration Research Analog (HERA) and the Crew Health and Performance Exploration Analog (CHAPEA) habitats. Selecting and recruiting …

Dynamic Homeostasis In Relaxation And Bursting Oscillations, Christopher J. Ryzowicz

Biology and Medicine Through Mathematics Conference

No abstract provided.

How Human Behavior Shapes Epidemic Dynamics, Leah Lejeune, Navid Ghaffarzadegan, Lauren M. Childs, Omar Saucedo

Biology and Medicine Through Mathematics Conference

No abstract provided.

Dynamics For Complex Quadratic Networks, Templates And Mutations, Anca R. Radulescu, Eva Kaslik, Alexander Fikl, Sarah Muldoon, Johan Nakuci, Mark Comerford

Biology and Medicine Through Mathematics Conference

No abstract provided.

Delineating Differences In Firing Rate Estimates Of Healthy And Parkinsonian Single-Unit Basal Ganglia Recordings, Richard R. Foster, Cheng Ly

Biology and Medicine Through Mathematics Conference

No abstract provided.

Artificial Photosynthesis To Overcome Oxygen Deprivation During Respiratory Disease Crisis-A Mini Review, Devadass Jessy Mercy Ms, Harini Rm Ms, Agnishwar Girigoswami Prof, Koyeli Girigoswami Prof

Chulalongkorn Medical Journal

Respiratory diseases are mainly treated using several symptomatic treatments, supported by oxygen for the patients. During the Coronavirus disease 2019 (COVID-19) pandemic, oxygen concentrators were in high demand, and even after that, many patients lost their lives to this pandemic due to a shortage of oxygen cylinders. This crisis instigated many entrepreneurs to open oxygen plants, which needed a large scale set up. The articles were searched using Google Scholar, Scopus, and Web of Science using appropriate keywords to write this review article. In this review, we have summarized the need for oxygen that can be overcome using artificial photosynthesis. …

Imaging Of The Centromedian Thalamic Nucleus Using 3d Fast Gray Matter Acquisition T1 Inversion Recovery Sequence In 3t Mri In Epilepsy, Tunchanok Paprad, Thanyachat Yutthakasaemsan, Supada Prakkamakul

Chulalongkorn Medical Journal

Background:

The centromedian thalamic nucleus (CM) is an emerging deep brain stimulation (DBS) target for neurological disorders, including drug-resistant epilepsy. Traditional DBS localization relies on predefined stereotactic coordinates, which may be imprecise. Novel MRI sequences enhance gray-white matter contrast, potentially allowing direct CM visualization, improving accuracy in DBS planning and targeting.

Objective:

This study evaluates the 3D Fast Gray Matter Acquisition T1 Inversion Recovery (FGATIR) MRI sequence for the visualization of the CM in epilepsy patients.

Methods:

This prospective IRB-approved descriptive study included adult epilepsy patients who underwent 3D FGATIR MRI sequence at 3 Tesla. Two neuroradiologists independently assessed CM …

Association Of Mirnas As Biomarkers For Severe Liver Dysfunction In Severe Dengue Infection, Napat Pas-Arj, Nattachai Srisawat, Umaporn Limothai, Sasipha Tachaboon, Janejira Dinhuzen

Chulalongkorn Medical Journal

Background: Identification early biomarkers for predicting severe liver dysfunction in severe dengue patients is essential. Currently, there is no any data on circulating microRNAs to predict this important complication.

Objectives: This study aimed to explore the role of circulating microRNAs in prediction severe liver dysfunction in dengue infection by identifying and validating predictive microRNAs via Nanostring and RT-qPCR.

Methods: On the initial day of admission, serum samples were gathered from patients with dengue infection. These patients were monitored for 14 days post-admission to ascertain their final diagnosis. Following the WHO 2009 criteria, participants were categorized into severe liver dysfunction and …

Psychosocial Predictors Of Depression And Anxiety In Thai Stroke Caregivers, Chanatip Tongyonk, Sorawit Wainipitapong, Chavit Tunvirachaisakul, Aurauma Chutinet, Michael Maes, Thitiporn Supasitthumrong

Chulalongkorn Medical Journal

Background: Caregivers of stroke survivors often face significant psychological challenges, yet limited research in Thailand has explored how patient and caregiver characteristics jointly influence caregiver mental health outcomes.

Objective: To identify characteristics of ischemic stroke patients and their caregivers that may predict distress, sadness, and anxiety symptoms in the caregivers.

Method: To measure caregivers' burden, stress, depression, and anxiety symptoms, the Hospital Anxiety and Depression Scale (HADS), Zarit Burden Interview (22-item ZBI), and Perceived Stress Scale (PSS-10) were utilized. To define a multi-step mediation model, we used partial least squares structural equation modelling (PLS-SEM).

Result: 97 stroke patients and their …

The Use Of Electronic Notifications To Improve Guideline Adherence In Amiodarone Adverse Reaction Monitoring, Naruepat Sangpornsuk, Teetouch Ananwattanasuk

Chulalongkorn Medical Journal

Background: Amiodarone is an antiarrhythmic drug that can cause side effects on the thyroid, liver, lungs, vision, and nervous system. Guidelines for monitoring and surveillance of these side effects have been established since 2000, but adherence to them is low in many countries including Thailand. An electronic alert system was implemented to remind physicians of the monitoring guideline at Vajira Hospital, Navamindradhiraj University, Thailand since 23 August 2023.

Objective: This study aimed to compare adherence with the amiodarone guideline before and after implementing an electronic notification system (primary outcome) and to assess the incidence of amiodarone-related adverse reactions (secondary outcome). …