Digital Commons Network^™

Gangrenous Diabetic Foot Treated With Homoeopathic Medicine Opium: A Case Report, Sarang Suhas Rahalkar, Neelam Sarang Rahalkar, Sonali Suresh Dhote, Deep Rasik Mandali

Indian Journal of Research in Homoeopathy

Introduction: Diabetic foot ulcer (DFU) is the most common neuropathic complication of diabetes. Uncontrolled diabetes and improper foot care lead to serious conditions like gangrenous DFU, even from minor injuries. DFU also has gangrene as one of its major complications. In general, people with diabetes have a significantly higher risk of developing lower extremity gangrene, which may lead to amputation. Case Summary: A known case of a 68-year-old man of type 2 diabetes mellitus for the past five years, was presented with painless DFU on his right leg that had persisted for the past 6 months. He was …

Nasal Polyp Treated With Homoeopathic Medicine Lemna Minor: An Evidence-Based Case Report, Milan Sengupta, Laijun Nahar, Gurudev Choubey, Chittaranjan Kundu

Indian Journal of Research in Homoeopathy

Introduction: In the general population, nasal polyps (NPs) linked to chronic rhinosinusitis (CRS) are common. Patients with CRS are 60–65% more likely to develop NP. Treatment for NPs resulting from chronic rhino-sinusitis continuous to be challenging. Case summary: A 31-year-old female came with a swelling in her left nostril, clinically diagnosed as a case of NP. Homoeopathic medicine Lemna minor 1M was prescribed based on the acute complaints and pathological symptoms. The swelling was completely resolved within 45 days. This case report demonstrates the usefulness of homoeopathic medicine in the management of NP.

Exfoliative Cheilitis Treated With Homoeopathic Medicine Nitricum Acidum: A Case Report, Dinesh Sura, Niharika Shaw, Rubina Bashir, Chintamani Nayak

Indian Journal of Research in Homoeopathy

Introduction: Exfoliative cheilitis is an uncommon, persistent inflammatory disorder that impacts the vermilion border of the lips, characterised by ongoing peeling, dryness, and occasional bleeding. The condition can be resistant to conventional treatment and often causes significant emotional distress. Case Summary: A 16-year-old male presented with chronic dry, scaly eruptions on his lips, accompanied with a burning sensation and bleeding for the past 8 months. He reported anxiety about his appearance and also about his father's health. Based on a thorough evaluation of his overall symptoms and repertorial analysis, he was prescribed a single dose of Nitricum acidum 200C. By …

Homoeopathic Treatment Of Multiple Verruca Vulgaris On Dorsal Aspect Of Hands: An Evidence-Based Case Report, Shweta Singh Kureel, Gurpreet Singh, Bharti Wadhwa

Indian Journal of Research in Homoeopathy

Introduction: Verruca vulgaris, widely recognised as warts, are benign epithelial growths with an exophytic nature, typically resulting from infection with the human papillomavirus (HPV). A general cutaneous ailment that can range in severity from a minor annoyance that resolves itself unexpectedly into a long-lasting condition. Homoeopathy aims to concentrate on the fundamental cause of the inherent susceptibility and tendency towards HPV infections by diminishing the size and occurrence of warts and enhancing the body's immune response, thereby minimising the risk of recurrence. Case Summary: A 46-year-old male presented at the outpatient clinic with multiple verruca vulgaris on the dorsal surfaces …

Homoeopathic Treatment Of Chronic, Relapsing Tinea Corporis: A Case Report, Lalit Kumar Chauhan, Shakti Priya

Indian Journal of Research in Homoeopathy

Introduction: Tinea corporis (dermatophysis) is a common dermatophytic infection that affects a significant proportion of the global population, with dermatophytosis accounting for nearly 20–25% of all superficial fungal infections worldwide. Increasing reports of resistance and relapse to conventional antifungal therapy highlight the need for alternative approaches. This case is unique in demonstrating how past history can decisively influence remedy selection in homoeopathic practice, contributing to the exsisting literature on individualised approaches for chronic, relapsing fungal infections. Case Summary: A 35-year-old female presented with multiple erythematous, scaly, pruritic plaques on the back and abdomen, with itching aggravated by sweating and tight …

Indian Standards For Methods Of Preparation Of Homoeopathic Mother Tinctures, Kumar Vivekanand, Daisy Katarmal, Indra Gaurav Saxena, Divya Taneja, Shrishti Dixit, Raj Kumar Manchanda

Indian Journal of Research in Homoeopathy

Homoeopathic mother tinctures form the foundation of homoeopathic pharmaceutical preparations, and their quality largely depends on the source material and the method of extraction. Standardisation of these processes of extraction is essential to ensure consistency, safety, therapeutic reliability, and reproducibility of preparations. The recently published Indian Standards IS 19327 (Part 1): 2025 and IS 19327 (Part 2): 2025 provide standardised procedures for the preparation of homoeopathic mother tinctures through maceration and percolation, respectively. This article reviews the salient features of these standards, including apparatus, materials, procedural steps, process modifications, and storage requirements. The standards emphasise the use of suitable extraction …

Homeopathy In Integrative Oncology: Ethical And Evidence Considerations, Sneha Pawar

Indian Journal of Research in Homoeopathy

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Cholelithiasis Treated With Homoeopathy: A Case Report, Girish Gupta

Indian Journal of Research in Homoeopathy

Introduction: The supersaturation of bile with cholesterol, necessary for maintaining bile salts in soluble state, leads to precipitation of cholesterol and other bile components in gallbladder lumen resulting in formation of gall stones. Cholelithiasis is a common digestive disorder that affects about 15% of people over 50 years of age, however in younger individuals it is common between the age of 20–40 years. Gall stones are asymptomatic in about 80% cases, but 1–4% of patients may present with symptoms like pain, nausea and vomiting etc. due to obstruction to bile flow. The treatment of gallbladder stone depends on the clinical …

Management Of Pilar Cyst On The Scalp With Individualised Homoeopathic Medicine: An Evidence-Based Case Report, Anindita Das, Suparja Sinha, Mihir Kanti Biswas

Indian Journal of Research in Homoeopathy

Introduction: Pilar cysts, also referred to as trichilemmal cysts, are benign cystic lesions that commonly occur on the scalp. Conventional management generally involves surgical excision. Homoeopathy provides an individualised, non-invasive therapeutic approach based on the totality of symptoms. Case summary: A 35-year-old female patient presented with a soft, cystic swelling on the scalp associated with itching and tenderness, clinically diagnosed as pilar cyst. Thuja occidentalis was prescribed on the basis of individualisation and a follow-up period of over twelve months showed gradual resolution of the cyst without any surgical intervention, along with improvement in general well-being. The patient was subsequently …

Delicate, Backward, Puny, And Stunted Children By J. Compton Burnett, M.D.- A Book Review, Shreyank Kotian

Indian Journal of Research in Homoeopathy

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Resolution Of Vocal Cord Papilloma With Potentised Causticum: An Evidence-Based Case Report, Partha Pratim Pal, Souvik Dutta

Indian Journal of Research in Homoeopathy

Introduction: Vocal cord papilloma, also known as laryngeal papilloma, is a benign wart-like growth on the vocal cord folds caused by the Human papilloma virus (HPV). This condition presents with symptoms such as hoarseness, stridor, dysphonia, and potential airway obstruction, depending on the size and location of the papillomas. Diagnosis of vocal cord papilloma involves laryngoscopy, a procedure used to visualise the growths on the vocal cords. Treatment options for vocal cord papilloma include surgical excision, laser therapy, and antiviral medications. Case Summary: A 55-year-old male attended the outpatient department of Dr. Anjali Chatterji Regional Research Institute for Homoeopathy, Kolkata, …

From Clinical Success To Scientific Publication: Writing Meaningful Homoeopathic Case Reports And Case Series, Chaturbhuja Nayak

Indian Journal of Research in Homoeopathy

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Issue Editorial: Case Reports Special, Subhash Kaushik

Indian Journal of Research in Homoeopathy

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Individualised Homoeopathic Treatment In Alopecia Areata: An Evidence-Based Case Series, Dinesh Sura, Niharika Shaw, Rubina Bashir, Rahnuma Rao, Ramakrishna Ghosh

Indian Journal of Research in Homoeopathy

Background: Alopecia areata (AA) is an autoimmune disease characterised by hair loss in patches from one or more areas of skin. While it can affect the scalp, it may occur in other parts of the body as well. No age group is predominantly affected. Objective: This case series evaluates the effects of individualised homoeopathic treatment in patients with AA. Method: A total of 5 cases are included in this study. AA was diagnosed based on presentation of clinical symptoms. Two patients improved with Phosphorus. Another two were prescribed Natrium muriaticum and Typhoidinum respectively. One patient improved with Tuberculinum when …

Intraepidermal Squamous Cell Carcinoma In Situ (Bowen's Disease) Managed With Classical Homoeopathy: A Case Report, Anastasia Leivada, Aaditi Lakshmana, Ioannis Constantaras, Seema Mahesh, George Vithoulkas

Indian Journal of Research in Homoeopathy

Introduction: Bowen's disease, also known as intraepidermal squamous cell carcinoma in situ (SCCIS), is a pre-cancerous skin condition with the potential for progression into invasive carcinoma. Long-term exposure to ultraviolet (UV) radiation from sunlight is considered a primary causative factor, leading to DNA damage and subsequent cellular mutations within the epidermis. Conventional treatments are generally effective but may be associated with complications, including pain, local infection, scarring, pigmentation changes, and occasional recurrence. Case summary: This case report describes a 58-year-old male with Bowen's disease who experienced limited benefit from conventional treatments and sought homoeopathic therapy. The patient was treated with …

Research Highlights, Sujata Madhukar, Sakshi Chaudhary

Indian Journal of Research in Homoeopathy

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Bridging The Evidence Gap: The Need For Scientific Research On The Effects Of Thiosinaminum In Adhesive Capsulitis, Nuzhatul Arab

Indian Journal of Research in Homoeopathy

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Athletic Training Preceptors' Accuracy In Assessing Ai-Generated Clinical Scenarios Aligned With Caate Educational Standards, Elisabeth (Beth) Shoulders

Graduate Theses, Dissertations, and Capstones

Athletic training preceptors play a critical role in clinical education by evaluating student competence; however, little is known about their preparedness to assess competency-based standards, particularly when using emerging tools such as artificial intelligence (AI). The purpose of this study was to examine preceptors’ accuracy in applying Commission on Accreditation of Athletic Training Education (CAATE) standards and classifying student proficiency within AI-generated clinical scenarios, and to determine whether accuracy differed based on preceptor characteristics.

This quantitative, cross-sectional study included Board of Certification-certified athletic trainers who had served as preceptors within the past five years (N = 68). Participants completed an …

In Silico Screening And Molecular Analyses Identify Apigenin From Scutellaria Barbata As A Potent Akt1 Inhibitor In Breast Cancer, Md. Maruf Khan, Md. Arju Hossain, Fatematuz Zohora, Md. Sohel, Md. Faisal Amin, Fatematuz Zuhura Evamoni, M. Nazmul Hoque

School of Integrative Biological & Chemical Sciences Faculty Publications

Breast cancer (BC) remains a leading cause of cancer-related mortality in women worldwide. Scutellaria barbata, a traditional Chinese medicinal herb, possesses recognized anticancer properties, but its mechanistic role in BC is not fully elucidated. This study employed an integrated in silico approach to identify the key flavonoids, targets, and pathways through which S. barbata exerts its anti-BC effects. A multi-step computational methodology incorporating network pharmacology, molecular docking, and dynamics simulations was utilized to profile bioactive compounds from S. barbata. From an initial set of 34 phytocompounds, three flavonoids namely apigenin, 4’-hydroxywogonin, and hispidulin demonstrated favorable drug-likeness, high bioavailability, …

Harmonizing Intervention, Context, And Implementation Strategies With Context-Driven Co-Design (Cd2), Sarah A Birken, Emily R Haines, Cheyenne R Wagi, Bonny B Morris, Kathryn E Weaver, Kathleen M Lisborg, Sara J Landes, Geoffrey M Curran, Miriam Bender, Maria E Fernandez, Ashley Strahley, Kimberly Wiseman, Kristie L Foley

Faculty, Staff and Student Publications

Background: Extant approaches to close the gap between implementation evidence and practice have been unsuccessful due in part to overreliance on researcher engagement. In practice, change is often driven by mid-level managers. We developed Context-Driven Co-Design (CD2) to equip mid-level managers with a theory- and evidence-based approach to implementation planning.

Methods: We used a two-pronged design. First, we engaged six established implementation researchers in a modified Delphi process, involving two hour-long meetings and asynchronous feedback to develop and refine a CD2 prototype. Second, we piloted an in-person CD2 training and conducted an hour-long focus group to solicit feedback from mid-level …

Impact Of Anatomical Changes On Treatment Plan Robustness: A Comparative Study Of Intensity Modulated Proton Therapy And Volumetric Modulated Arc Therapy In Head And Neck Cancer., Jennifer Croft

Masters Projects

Head and neck cancer patients often experience anatomical changes during radiation therapy, including weight loss and tumor regression. These changes can alter planned dose distribution and affect treatment accuracy. Based on the previous understanding, IMPT offers highly conformal dose delivery but is sensitive to the patient’s geometry changes and daily setup uncertainties, while VMAT may provide greater stability under these uncertainties. However, as of today, there is no quantitative analysis and comparison between the two modalities using real clinical data. The purpose of this study is to compare the robustness of IMPT and VMAT for head and neck cancer by …

Tea Polyphenol-Assisted Green Synthesis Of Silver Nanoparticle-Boron-Doped Diamond Nanoparticles For Theophylline Electrochemical Detection, Prastika Krisma Jiwanti, Adira Ainun Tsalsabilla, Angellita Wijaya Gunawan, Siti Wafiroh, Mohammad Kalimanjaro, Mai Tomisaki

Makara Journal of Science

Drug theophylline is a bronchodilator used to treat asthma and chronic obstructive pulmonary disease (COPD), but precise monitoring is required to avoid side effects. Therefore, this study aimed to develop a screen-printed electrode (SPE) modified with a composite of green-synthesized silver nanoparticles and boron-doped diamond nanoparticles using tea polyphenols (Ag-BDDTP/SPE) for detecting theophylline. Formation of AgNPs was confirmed by UV-Vis spectroscopy, which showed a localized surface plasmon resonance peak at ~450 nm. Transmission electron microscopy revealed polydisperse nanoparticles with an average diameter of 39.94 nm. During the electrochemical detection of theophylline, square-wave voltammetry (SWV) was employed to evaluate signal-to-background (S/B) …

Mutation Screening For Confirming Suspected Spinal Muscular Atrophy Using Dried Blood Spotted On In-House Cellulose-Based Cards, Yogik Onky Silvana Wijaya, Farda Tsaqouva Ahza, Annisa Naufal Almaszahra, Mawaddah Ar Rochmah, Dian Kesumapramudya Nurputra

Makara Journal of Science

Early and accurate diagnosis for spinal muscular atrophy (SMA) has gained relevance in an era of emerging therapies to improve patient outcomes. While screening of dried blood spots (DBS) effectively detects deletion-type SMA, non-deletion cases are often missed. Mutation screening from DBS is needed to address this gap. Here, we aimed to evaluate the feasibility of an in-house, cellulose-based card for direct Sanger sequencing for variant hunting, avoiding DNA extraction and offering an alternative to commercial cards. As a proof of concept, sequences obtained from DBSs of 23 healthy individuals were compared with sequences derived from isolated genomic DNA (gDNA). …

Does Set Configuration Influence Long-Term Adaptations To Complex Training In National-Level Wrestlers? A Volumematched Randomized Trial, Yueqiang Ma, Pengpeng Gou, Yuxiong Huang, Jialiang Yu, Lijia Zhou, Kai Xu, Binbin Jia, Danyang Li

Research outputs 2022 to 2026

Objectives: Complex training is commonly used to enhance strength and explosive performance in athletes; however, the long-term influence of set configuration within complex training remains unclear in highly trained wrestlers. This randomized, volumematched trial investigated whether set configuration influences long-term adaptations to complex training (CT) in national-level male Chinese-style wrestlers. Specifically, the study compared the effects of cluster-set complex training (CS-CT) and traditional-set complex training (TS-CT) on maximal strength, lower-limb explosive performance, anaerobic power, and sport-specific performance.

Methods: Sixteen highly trained wrestlers (Tier 3; n=16) completed an 8-week lowerbody CT program performed twice weekly. Participants were randomly allocated to either …

Effectiveness Of Lay Workers Delivering Behavioural Activation For People With Depression: Systematic Review And Meta-Analysis, Shwikar Othman, Lauren Blekkenhorst, Asangaedem Akpan, Irene Ngune, Nilufeur Mckay, Alison Kennedy, Elizabeth Armstrong, Michael Hunter, Kevin Murray, Mathew Coleman, Richard Gray, Emma Jones, Christopher Lee, Martin Jones

Research outputs 2022 to 2026

Background Behavioural activation is effective for depression, but its effectiveness in treating adults with depression when delivered by lay workers remains unclear. Aims To examine the effectiveness of behavioural activation delivered by lay workers, compared with any control group, in reducing depressive symptoms in adults. Method This systematic review searched six databases from inception to January 2025, for randomised controlled trials (RCTs) comparing behavioural activation and any control conditions for individuals with depression when delivered by lay workers. Additional searches were conducted in the international trial registries and reference lists (PROSPERO registration CRD42024625620). Risk of bias was assessed using the …

Real-World Outcomes Of Dedicated Leaflet Modification For Bioprosthetic Valve-In-Valve Tavr: A 150-Patient Commercial Experience., Raj R Makkar, Aakriti Gupta, Ignacio Inglessis, Curtiss T Stinis, Pradeep K Yadav, Vinod H Thourani, Stanley J Chetcuti, Matthew Summers, Vivek Patel, Bassem M Chehab, Apurva Patel, Gilbert H L Tang, Sahil Khera, Michael Rinaldi, Trevor Simard, Jeffrey Southard, Benjamin R Stripe, Brian Whisenant, Keith Allen, Yoseph Rozenman, Danny Dvir, Carlos E Sanchez, Jeffrey Popma, Martin B Leon, Philippe Généreux

Heart and Vascular Articles

BACKGROUND: Coronary obstruction during valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) is infrequent but catastrophic. Mechanical splitting of bioprosthetic leaflets may mitigate this risk, but real-world experience remains limited.

OBJECTIVES: The aim of this is to evaluate procedural performance and in-hospital outcomes of a dedicated mechanical leaflet-splitting device in ViV TAVR.

METHODS: Consecutive postapproval cases were performed at 28 centers from February to November 2025. Patients were selected for elevated risk based on preprocedural computed tomography criteria, including virtual valve-to-coronary distance ≤4 mm and/or virtual valve-to-sinotubular junction distance ≤3 mm. Procedural outcomes were assessed among patients in whom splitting was …

Efficacy Of Post-Transplant Brentuximab Vedotin Maintenance By Pre-Transplant Disease Status In Relapsed/Refractory Classic Hodgkin Lymphoma, Sanjal H Desai, Brad Kahl, Raya Saba, Et Al.

2020-Current year OA Pubs

Patients with classic Hodgkin lymphoma (cHL) with primary refractory disease, early relapse, or extranodal disease have a higher risk of relapse after salvage therapy and autologous stem cell transplant (ASCT). Post-ASCT brentuximab vedotin (BV) maintenance improved progression-free survival (PFS) in high-risk relapsed/refractory (R/R) cHL in the AETHERA trial, but subgroup analysis suggested that the benefit in patients transplanted in complete metabolic response (CMR) is unclear. In a large international real-world cohort, we assessed the efficacy of BV maintenance stratified by pre-ASCT metabolic response and by the number of clinical risk factors as defined in the AETHERA trial. Adult patients with …

Scholarship, Discovery, And The Formation Of Physicians, Anderson Spickard

Cumberland Medica

The launch of Cumberland Medica marks an important milestone for the Thomas F. Frist, Jr. College of Medicine. More than a journal, it reflects something we hope will be deeply woven into our culture: a community of learners committed to discovery, scholarship, and the formation of physicians. This issue showcases the work of our students while also reflecting the scholarship, mentorship, and educational leadership of faculty and staff. More importantly, it reflects our belief that scholarship is not simply about producing knowledge. It is one of the ways physicians learn how to see.

Refining Of An Online Rotator Cuff Related Pain Screening Tool (Orcs): A Mixed Methods Refinement Study, Andrew J. Smythe, Rhiannon Whale, Melanie Farlie, Peter Malliaras

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study is to refine an online rotator cuff related shoulder pain screening tool. Method: A mixed methods item-refinement study was used. The original tool was designed through expert opinion and informal literature review. In this study the original tool was refined over three rounds of cognitive interviews totalling 39 participants. The screening tool consisted of two sections, red flag screening followed by rotator cuff related shoulder pain differential diagnostic items. Results from each round of interviews were summarised and informed a nominal group research panel review process to modify items and develop a finalised version …

Objectively And Subjectively Measured Physical Activity Levels Among Children And Adolescents In Poland (2012–2022): A Systematic Review, Jarosław Herbert, Vasylyna Petrovets

Baltic Journal of Health and Physical Activity

This article aims to provide a comprehensive review of research on physical activity levels among children and adolescents in Poland from 2012 to 2022, considering both objective and subjective assessment methods. A systematic review of the literature was conducted in accordance with the PRISMA reporting recommendations. PubMed, Scopus, Web of Science, Google Scholar databases, as well as Polish scientific databases were searched. The review included studies published from 2012 to 2022, on children and adolescents aged 3–18 living in Poland, assessing physical activity levels using objective and/or subjective methods. This analysis of the selected studies showed that physical activity levels …