Digital Commons Network^™

Modern Molecular Profiling Recontextualizes The Nrg/Rtog 0539 Trial And Reveals Hidden High-Risk And Radiotherapy-Resistant Meningiomas, Leeor S Yefet, Clifford Robinson, Et Al.

2020-Current year OA Pubs

BACKGROUND: Meningiomas exhibit clinical heterogeneity. Radiotherapy (RT) remains the only adjuvant therapy, but tumor-control is variable, and biomarkers are limited. NRG/RTOG-0539 is the first prospective phase 2 trial to stratify meningioma patients for adjuvant RT based on clinical risk. Here, we apply modern molecular tools to this cohort and identify correlates of RT response.

METHODS: Tumor tissue from 100 RTOG-0539 patients was profiled using DNA methylation arrays, RNA sequencing, and whole-exome sequencing. Recurrence scores, Molecular Groups, gene expression, and copy number alterations were compared across clinical groups and between RT responders and non-responders; non-response was defined as progression or death …

Enhancing Validation Of Case-Control Omics Signatures Through "Minimalist" Single-Subject Analysis (N-Of-1 Trials): Proof Of Concept In Sepsis, Liam S Wilson, Nima Pouladi, Rachel F Nelson, Elizabeth A Middleton, Neal D Tolley, Mahdieh Shabanian, Colleen Kenost, Robert A Campbell, Matthew T Rondina, Yves A Lussier

2020-Current year OA Pubs

OBJECTIVE: To evaluate if a single-subject study (S3) design, utilizing paired transcriptome samples from the same patient (eg, "sepsis" vs "recovered"), can replicate transcriptomic signatures from small case-control studies, addressing challenges in patient accrual for rare or sub-stratified diseases.

METHODS: We generated a sepsis gene signature (SGS) comprising 300 differentially expressed genes (DEGs; FDR <  5%) from a human sepsis case-control cohort using general linear models (GLMs). Reproducibility of SGS was assessed through three approaches applied to sub-sampled independent datasets: single-subject analyses (N-of-1-MixEnrich), anticipated to perform better; conventional paired-sample GLM analyses; and a traditional case-control GLM analysis.

RESULTS: SGS reproducibility in GLM analyses was inconsistent at smaller cohort sizes (∼80% reproducibility; n = 5) but stabilized at cohort sizes >6. Remarkably, the single-subject-study approach consistently reproduced SGS in each of the 18 subjects individually (100% reproducibility; n = 1).

DISCUSSION: Conventional GLMs are …

Delayed Diagnosis Of A Rare Metabolic Disorder In Adulthood, Isaiah K Mensah, Angie Carreno Martinez, Taylor Wilson, Miguel Valdez, Maria Laura Duque Lasio

2020-Current year OA Pubs

No abstract provided.

Characteristics Of Mortality In Hiv-Negative Cryptococcosis Patients: Analysis Of A Cohort Of 743 Patients, Kai Dai, Xinyao Jian, Chongliang Luo, Siguang Wang, Qiyu Pan, Xiaofeng Xu, Jia Liu, Fuhua Peng, Yong Chen, Ying Jiang

2020-Current year OA Pubs

BACKGROUND: Reports of cryptococcosis among patients without human immunodeficiency virus (HIV) infection are increasing. However, there is still a lack of data regarding the mortality characteristics in this population.

METHOD: The clinical, laboratory, imaging data from 743 HIV-negative patients with cryptococcosis were analyzed. Kaplan-Meier analysis was used to estimate all-cause mortality at 2-week, 10-week, and 1-year, with comparisons between groups using log-rank tests. Risk factor analysis was conducted using Cox models. Additionally, a meta-analysis was conducted on four recent large-scale cohort studies to investigate the differences in 2-week mortality of HIV-negative cryptococcosis across different regions. Statistical analyses were performed using …

Improving Infant Health Equity: What Have We Learned, What Do We Do, Dewayne M Pursley, F Sessions Cole

2020-Current year OA Pubs

The United States neonatal and infant mortality rates have declined substantially over the last six decades. Despite these reductions, significant racial disparities in mortality and other important outcomes have persisted. While increased risk of preterm birth is a major contributor to these differences, racial inequities in risk-adjusted outcomes such as gestational age-specific and major congenital anomaly-associated mortality remain. Race-specific differences in inter- and intra-neonatal intensive care unit (NICU) practices associated with worse outcomes for infants of color suggest opportunities for reducing these disparate health outcomes during and after NICU hospitalization. Identifying NICU-based contributing factors and implementing factor-specific improvement strategies can …

Cardiorespiratory Signatures Of Necrotizing Enterocolitis: A 4-Nicu Study Of Very Low Birth Weight Infants, Sherry L Kausch, Zachary A Vesoulis, Colm P Travers, Carie Taveras, Rachel Benz, Amanda Duncan, Angela K S Gummadi, Katy N Krahn, Rakesh Sahni, Joseph Isler, Namasivayam Ambalavanan, J Randall Moorman, Douglas E Lake, Karen D Fairchild, Brynne A Sullivan

2020-Current year OA Pubs

BACKGROUND: Necrotizing enterocolitis (NEC) is a disorder in very low birth weight (VLBW, < 1500 g) infants, associated with significant morbidity and mortality. Earlier detection of NEC may improve outcomes. We hypothesized that NEC's physiological signature resembles that of sepsis and that our model developed for sepsis, the Pulse Oximetry Warning System (POWS), would also predict NEC.

OBJECTIVES: Assess relationships between continuous heart rate (HR) and oxygen saturation (SpO

METHODS: In a retrospective multicenter analysis, we studied VLBW infants at four level IV NICUs, identifying cases of late-onset sepsis (LOS) and NEC (Bell stages 2 or 3). Using HR and SpO

RESULTS: Among 3914 infants evaluated, 5% had NEC and 13% had LOS. Cardiorespiratory data analysis showed that HR/SpO

CONCLUSION: NEC shares a cardiorespiratory signature with LOS. POWS predicted NEC with a dynamic rise before clinical diagnosis.

IMPACT: A cardiorespiratory early warning score analyzing …

Double Trouble: A Case Series Of Patients With Primary Lung And Esophageal Cancer, Srineil Vuthaluru

Graduate Medical Education Research Journal

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A Rhabdo Roller Coaster: Delayed Diagnosis Of Mcardle Disease In A Patient With Recurrent Non- Traumatic Rhabdomyolysis, Marilee Schaner

Graduate Medical Education Research Journal

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A Severe Presentation Of Sickle Cell Crisis, Marilee Schaner

Graduate Medical Education Research Journal

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Vaccination Attitudes Of Migrant And Seasonal Farm Workers In Iowa: Analysis Of A Clinical Survery, Jenna Mccoy

Graduate Medical Education Research Journal

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Loss Of Cd44 On Immunohistochemistry Shows Increased Likelihood Of Early Recurrence In Non- Invasive Low-Grade Papillary Urothelial Carcinoma With A Minor (< 5%) High-Grade Component, Holly Mitzel

Graduate Medical Education Research Journal

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Technical Validation Of Insulin Immunoassay For Cross-Reactivity Of Veterinary Insulins, Kristina Sevcik

Graduate Medical Education Research Journal

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Liberal Renal Sinus Sampling After Introduction Of Subspecialized Genitourinary Practice Leads To Upstaging And Optimal Management Of Renal Cell Carcinoma, Rory Li

Graduate Medical Education Research Journal

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Primary Cutaneous Marginal Zone Lymphoma With Admixed Hodgkin Lymphoma: A First Of Its Kind Of Collision, Pauline Xu

Graduate Medical Education Research Journal

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Ebv-Negative T-Cell Post-Transplant Lymphoproliferative Disorder Of The Skin With Ebv-Positive Diffuse Large B-Cell Lymphoma Of The Intestine In A Multi-Organ Transplant Recipient Child, Pauline Xu

Graduate Medical Education Research Journal

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Primary Cutaneous High-Grade Extra-Skeletal Osteosarcoma: A Rare Case Report, Pauline Xu

Graduate Medical Education Research Journal

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Dupilumab-Associated Mycosis Fungoides: Unmasked, Direct Effect, Or A Lymphoid Reaction?, Pauline Xu

Graduate Medical Education Research Journal

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Beyond Pituitary Neuroendocrine Tumors: Spectrum Of 1101 Sellar/Suprasellar Region Masses In A Tertiary Referral Center In 36 Years, Lili Guo

Graduate Medical Education Research Journal

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Characterization Of Chronic Intestinal Pseudo-Obstruction With Abnormal Cd117 Staining: A Distinct Clinical Phenotype?, Holly Mitzel

Graduate Medical Education Research Journal

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Calcific Emboli From Valvular Heart Disease: A Cause Of Retinal And Cerebral Ischemic Events – A Case Series, Praneeth Thadi

Graduate Medical Education Research Journal

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Fatal Hemorrhagic Transformation In Acute Thalamic Ischemic Stroke Following Dual Antiplatelet Therapy And Prophylactic Enoxaparin, Praneeth Thadi

Graduate Medical Education Research Journal

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If It Quacks Like A Duck, Brendan Hurley

Graduate Medical Education Research Journal

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A Purulent Surprise, Brendan Hurley

Graduate Medical Education Research Journal

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Cardio-Bariatrics In Advanced Heart Failure, Chukwuebuka Ubochi

Graduate Medical Education Research Journal

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Culture Negative Endocarditis Secondary To Neisseria Gonorrhoeae, Miranda Jangula

Graduate Medical Education Research Journal

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Practice Patterns Among Providers Regarding Amiodarone Use For Atrial Fibrillation In The Inpatient Setting, Kevan English

Graduate Medical Education Research Journal

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Lead I Sign In Ecg: An Underrecognized Truth Or A Myth?, Anis Abobaker

Graduate Medical Education Research Journal

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Tracheitis: A Rare Respiratory Manifestation Of Ulcerative Colitis, Carter Schulz

Graduate Medical Education Research Journal

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Non-English Speaking Patient Hospital Follow-Up Rates Within The Nebraska Medicine System, Simone Jacoby

Graduate Medical Education Research Journal

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Reducing No-Show Rates At A Resident Primary Care Clinic – A Quality Improvement Project, Kelsey Coziahr

Graduate Medical Education Research Journal

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