Biological Aging Markers In Blood And Brain Tissue Indicate Age Acceleration In Alcohol Use Disorder, Lea Zillich, Metin Cetin, Elisabeth M Hummel, Eric Poisel, Gabriel R Fries, Josef Frank, Fabian Streit, Jerome C Foo, Lea Sirignano, Marion M Friske, Bernd Lenz, Sabine Hoffmann, Kristina Adorjan, Falk Kiefer, Georgy Bakalkin, Anita C Hansson, Falk W Lohoff, Olli Kärkkäinen, Eloise Kok, Pekka J Karhunen, Greg T Sutherland, Consuelo Walss-Bass, Rainer Spanagel, Marcella Rietschel, Dirk A Moser, Stephanie H Witt

Faculty, Staff and Student Publications

Background: Alcohol use disorder (AUD) is associated with increased mortality and morbidity risk. A reason for this could be accelerated biological aging, which is strongly influenced by disease processes such as inflammation. As recent studies of AUD show changes in DNA methylation and gene expression in neuroinflammation-related pathways in the brain, biological aging represents a potentially important construct for understanding the adverse effects of substance use disorders. Epigenetic clocks have shown accelerated aging in blood samples from individuals with AUD. However, no systematic evaluation of biological age measures in AUD across different tissues and brain regions has been undertaken.

Methods: …

Profiles Of Activity Engagement And Depression Trajectories As Covid-19 Restrictions Were Relaxed, Jonathan L. Chia, Andree Hartanto, William Tov

Research Collection School of Social Sciences

Given elevated depression rates since the onset of the pandemic and potential downstream implications, this research examined the association between activity engagement and depression among middle-aged and older adults postlockdown. This study aimed to (a) identify activity engagement profiles among middle-aged and older adults, (b) understand factors associated with profile memberships, and (c) compare depression trajectories across profiles as COVID-19 restrictions eased over 16 months in Singapore. This longitudinal study involved 6,568 middle-aged and older adults. Latent growth analysis was first conducted to obtain estimates of depression trajectories for each individual. Latent profile analysis was then conducted to identify different …

Core Requirements Of Frailty Screening In The Emergency Department: An International Delphi Consensus Study, Elizabeth Moloney, Christopher R Carpenter, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Frailty is associated with adverse outcomes among patients attending emergency departments (EDs). While multiple frailty screens are available, little is known about which variables are important to incorporate and how best to facilitate accurate, yet prompt ED screening. To understand the core requirements of frailty screening in ED, we conducted an international, modified, electronic two-round Delphi consensus study.

METHODS: A two-round electronic Delphi involving 37 participants from 10 countries was undertaken. Statements were generated from a prior systematic review examining frailty screening instruments in ED (logistic, psychometric and clinimetric properties). Reflexive thematic analysis generated a list of 56 statements …

Calorie Restriction Reduces Biomarkers Of Cellular Senescence In Humans, Zaira Aversa, Susan B Racette, Et Al.

2020-Current year OA Pubs

Calorie restriction (CR) with adequate nutrient intake is a potential geroprotective intervention. To advance this concept in humans, we tested the hypothesis that moderate CR in healthy young-to-middle-aged individuals would reduce circulating biomarkers of cellular senescence, a fundamental mechanism of aging and aging-related conditions. Using plasma specimens from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 study, we found that CR significantly reduced the concentrations of several senescence biomarkers at 12 and 24 months compared to an ad libitum diet. Using machine learning, changes in biomarker concentrations emerged as important predictors of the change …

Potential Causal Association Between Gut Microbiome And Posttraumatic Stress Disorder, Qiang He, Wenjing Wang, Dingkang Xu, Yang Xiong, Chuanyuan Tao, Chao You, Lu Ma, Junpeng Ma, Caroline M. Nievergelt, Adam X. Maihofer, Torsten Klengel, Elizabeth G. Atkinson, Chia Yen Chen, Karmel W. Choi, Jonathan R.I. Coleman, Shareefa Dalvie, Laramie E. Duncan, Mark W. Logue, Allison C. Provost, Andrew Ratanatharathorn, Murray B. Stein, Katy Torres, Allison E. Aiello, Lynn M. Almli, Ananda B. Amstadter, Søren B. Andersen, Ole A. Andreassen, Paul A. Arbisi, Ariane Rung, Et Al

School of Public Health Faculty Publications

Background: The causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential causal association using mendelian randomization (MR). Methods: The summary-level statistics for gut microbiome were retrieved from a genome-wide association study (GWAS) of the MiBioGen consortium. As to PTSD, the Freeze 2 datasets were originated from the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), and the replicated datasets were obtained from FinnGen consortium. Single nucleotide polymorphisms meeting MR assumptions were selected as instrumental variables. The inverse variance weighting (IVW) method was employed as the …

Identifying Barriers To Mental Health Services Utilization For Black Youth In The United States: A Qualitative Study, Emily Stein, Matthew Hutnyan, Neely Myers

SMU Journal of Undergraduate Research

Mental health in Black communities and racial/ethnic disparities in mental health service utilization remain growing concerns. Evidence suggests that psychotic disorders may be more prevalent among Black individuals than white individuals and the Black community faces barriers to care that can negatively influence outcomes. To better understand these barriers, we interviewed mental healthcare providers (n = 11) and Black young adults with first-person experience of psychosis (n = 13) about the experiences of minority young adults with mental health treatment. We analyzed interview transcripts and, consistent with constructivist grounded theory methods, identified iterative patterns across individuals about barriers to care. …

Major Stressful Life Events And The Risk Of Pancreatic, Head And Neck Cancers: A Case-Control Study, Arthi Sridhar, Vishaldeep Kaur Sekhon, Chandler Nguyen, Kamelah Abushalha, Amirali Tahanan, Mohammad Hossein Rahbar, Syed Hasan Jafri

Faculty, Staff and Student Publications

BACKGROUND: Major stressful life events have been shown to be associated with an increased risk of lung cancer, breast cancer and the development of various chronic illnesses. The stress response generated by our body results in a variety of physiological and metabolic changes which can affect the immune system and have been shown to be associated with tumor progression. In this study, we aim to determine if major stressful life events are associated with the incidence of head and neck or pancreatic cancer (HNPC).

METHODS: This is a matched case-control study. Cases (CAs) were HNPC patients diagnosed within the previous …

Effect Of Testosterone Replacement Therapy On Sexual Function And Hypogonadal Symptoms In Men With Hypogonadism, Karol M Pencina, Thomas G Travison, Glenn R Cunningham, A Michael Lincoff, Steven E Nissen, Mohit Khera, Michael G Miller, Panagiotis Flevaris, Xue Li, Kathleen Wannemuehler, Shalender Bhasin

Faculty, Staff and Students Publications

Context: Few long-term randomized trials have evaluated the efficacy of testosterone replacement therapy (TRT) in improving sexual function and hypogonadal symptoms in men with hypogonadism and whether effects are sustained beyond 12 months.

Objective: The Testosterone Replacement therapy for Assessment of long-term Vascular Events and efficacy ResponSE in hypogonadal men (TRAVERSE) study evaluated the effect of TRT on major adverse cardiovascular events in middle-aged and older men with hypogonadism. The Sexual Function Study, nested within the parent trial, determined testosterone's efficacy in improving sexual activity, hypogonadal symptoms, libido, and erectile function among men reporting low libido.

Methods: Among 5204 men, …

Practice And Recommendations For Universal Design For Learning In Occupational Therapy Client Education, Heather L. Panczykowski, Lynne F. Murphy, Victoria Christmas, Whitely Macintyre

The Open Journal of Occupational Therapy

Background: Universal Design for Learning (UDL), an educational framework that describes flexible approaches to teaching and learning, can be used to address problems related to limitations in health literacy in health care settings.

Methods: This exploratory observational study, using a web-based online survey, was undertaken to discern how occupational therapists use the principles of UDL in educating their clients and to determine if differences exist between degree type or practice settings and UDL implementation.

Results: Of the 147 respondents only 30.6% indicated prior awareness of UDL principles. The most frequently cited means of client engagement were displaying …

Qiditangshen Granules Alleviates Diabetic Nephropathy Podocyte Injury: A Network Pharmacology Study And Experimental Validation In Vivo And Vitro, Fei Gao, Ying Zhou, Borui Yu, Huidi Xie, Yang Shi, Xianhui Zhang, Hongfang Liu

Faculty, Staff and Student Publications

BACKGROUND: QiDiTangShen granules (QDTS), a traditional Chinese medicine (TCM) compound prescription, have remarkable efficacy in diabetic nephropathy (DN) patients, and their pharmacological mechanism needs further exploration.

METHODS: According to the active ingredients and targets of the QDTS in the TCMSP database, the network pharmacology of QDTS was investigated. The potential active ingredients were chosen based on the oral bioavailability and the drug similarity index. At the same time, targets for DN-related disease were obtained from GeneCards, OMIM, PharmGKB, TTD, and DrugBank. The TCM-component-target network and the protein-protein interaction (PPI) network were constructed with the Cytoscape and STRING platforms, respectively, and …

Innovative Virtual Wellness Interventions At An Academic Medical Center: A Pilot Feasibility Study, Ritika Baweja, Michael Hayes, Aditya Joshi, Raman Baweja

Journal of Wellness

Introduction: There is generally a concerning likelihood of burnout in healthcare workers. Given the impact of COVID-19 on healthcare workers, our institution identified the need for wellness interventions to foster adaptive functioning and mitigate burnout. The purpose of this pilot project was to assess the feasibility of virtual holistic interventions like meditation, art, laughter therapy and dance and their impact on overall well-being of physicians and advanced practice providers (APPs).

Methods: A series of 12 virtual sessions (art therapy, dance therapy, mindfulness-based practices/meditation and laughter therapy) were offered to providers over a 6-month period. Participants completed an online survey reporting …

Aging Fly Cell Atlas Identifies Exhaustive Aging Features At Cellular Resolution, Kenneth A Wilson, Sudipta Bar, Eric B Dammer, Enrique M Carrera, Brian A Hodge, Tyler A U Hilsabeck, Joanna Bons, George W Brownridge, Jennifer N Beck, Jacob Rose, Melia Granath-Panelo, Christopher S Nelson, Grace Qi, Akos A Gerencser, Jianfeng Lan, Alexandra Afenjar, Geetanjali Chawla, Rachel B Brem, Philippe M Campeau, Hugo J Bellen, Birgit Schilling, Nicholas T Seyfried, Lisa M Ellerby, Pankaj Kapahi

Faculty, Staff and Students Publications

Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediated lifespan extension in female flies. We found that mtd/OXR1 expression declines with age and it interacts with the retromer, which regulates trafficking of proteins and lipids. Loss of mtd/OXR1 destabilized the retromer, causing improper protein trafficking and endolysosomal defects. Overexpression of retromer genes or pharmacological restabilization with R55 rescued lifespan and neurodegeneration in mtd-deficient flies and endolysosomal defects in fibroblasts from patients with lethal loss-of-function …

Exploring The Relationship Between Staffing And Long-Term Care Worker Mental Health, Matthew R. Trombley

Doctoral Dissertations and Projects

This research delves into the relationship between staffing levels during a crisis in the healthcare workforce and the mental well-being of long-term care workers, with a specific focus on variables such as burnout, compassion fatigue, and compassion satisfaction. With increasing workforce shortages, the attention to providing quality care during this tumultuous period has become increasingly urgent. There has been scarce empirical research that has explicitly sought to comprehend the connection between staffing levels and the mental health of long-term care professionals. This study was designed as a non-experimental, quantitative correlational investigation, aiming to understand the intricate dynamics between patient-to-staff ratios …

Ageannomo: A Knowledgebase Of Multi-Omics Annotation For Animal Aging, Kexin Huang, Xi Liu, Zhaocan Zhang, Tiangang Wang, Haixia Xu, Qingxuan Li, Yuhao Jia, Liyu Huang, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

Aging entails gradual functional decline influenced by interconnected factors. Multiple hallmarks proposed as common and conserved underlying denominators of aging on the molecular, cellular and systemic levels across multiple species. Thus, understanding the function of aging hallmarks and their relationships across species can facilitate the translation of anti-aging drug development from model organisms to humans. Here, we built AgeAnnoMO (https://relab.xidian.edu.cn/AgeAnnoMO/#/), a knowledgebase of multi-omics annotation for animal aging. AgeAnnoMO encompasses an extensive collection of 136 datasets from eight modalities, encompassing 8596 samples from 50 representative species, making it a comprehensive resource for aging and longevity research. AgeAnnoMO characterizes …

Dukungan Sosial Dari Orang Tua Asuh Kepada Anak Berhadapan Dengan Hukum Dalam Proses Rehabilitasi Sosial, Muhamad Rizky Hidayat, Annisah Annisah, Dwi Amalia Chandra Sekar

Jurnal Ilmu Kesejahteraan Sosial

The social rehabilitation process in which children face legal conflict is not easy, especially when they are far from their families. This article aims to examine the forms and benefits of social support from foster parents to Children in Conflict with the Law (ABH) who are undergoing the process of social rehabilitation. Descriptive qualitative research was conducted at the Social Rehabilitation Center for Children who Need Special Protection (BRSAMPK). This research was conducted in March-July 2021. Data collection was carried out through in-depth interviews with 13 informants, consisting of children in conflict with the law, heads of social services and …

Nsu Health Professions Division 2023-2024 Course Catalog, Nova Southeastern University

HPD Course Catalogs

Nova Southeastern University Health Professions Division:

• Dr. Kiran C. Patel College of Osteopathic Medicine
• College of Pharmacy
• College of Optometry
• Dr. Pallavi Patel College of Health Care Sciences
• College of Dental Medicine
• Ron and Kathy Assaf College of Nursing
• Dr. Kiran C. Patel College of Allopathic Medicine

Library & Knowledge Services Newsletter - Winter 2023/24, Baystate Health Sciences Library

Library Newsletters

Library & Knowledge Services Newsletter - Winter 2023/24

Physical Activity And Reduced Risk Of Cognitive Decline, Ashley Tolentino, Erika Mccarthy, Travis Adelman, Taryn Pearl

Doctor of Medical Science (DMSc)

Similar to dementia management, treatment of mild cognitive impairment includes both non-pharmacologic and pharmacologic options to help prevent progression of further cognitive decline and dementia. Pharmacologic treatment of reversible causes include discontinuation of medications causing cognitive side effects, treating sleep disturbances, treating depression , and correcting deficiencies in vitamin B12 or thyroid hormone.² Another important step includes vascular risk factor modification with pharmacologic treatment of hypertension, which has been identified as an important risk factor of dementia. ³Non-pharmacologic interventions include various methods of cognitive rehabilitation (e.g., memory training and exercise). Exercise programs lasting 6 to 12 months have …

Exploration Of Associations Between Asthma And Depression In Older American Adults: A Pooled Cross-Sectional Analysis Of Medicare Recipients, Brian Ring

Graduate Research Theses & Dissertations

Background

While unclear in older populations within the US, individuals with asthma are disproportionally affected by depression relative to those without asthma. This work explores the associations between asthma, depression, sociodemographic, and disease-related factors in a US population ≥ 65 years of age.

Methods

A pooled cross-sectional analysis of Medicare Current Beneficiary Survey (MCBS) data was utilized to determine the association between asthma and depression from 2018 to 2020. Depression was defined as a score of ≥ 10 from the Patient Health Questionnaire-9 (PHQ-9). Disease-related variables were recorded if the subject met Medicare claims criteria for the calendar year. Multivariable …

Progression Magazine, 2023-2024, Coastal Carolina University

Progression Magazine

Magazine of the Gupta College of Science at Coastal Carolina University.

Addressing Occupational Deprivation And Alienation In Rural Skilled Nursing Facilities Through An Activities Resource Guide, Stephanie Dullum

Frank Low Research Day Posters

The purpose of this product was to create a resource guide on leisure activities for the activities department in a rural skilled nursing facility (SNF) to address common chronic conditions and support the needs or wants of the SNF residents.  With aging comes more chronic conditions and less physical activity, socialization, and time engaged in meaningful activities, affecting quality of life(QOL) and well-being (Causey-Upton, 2015; Cudjoe et al., 2020; Nedjeljeko et al., 2021; Portillo etal., 2023; Sen et al., 2022; Small field & Molitor, 2018;World Health Organization [WHO], 2022). Providing residents with more meaningful leisure activities will assist the …

The Impact Of Mobile Technology Interventions With Older Adults Diagnosed With A Cognitive Deficit, Emily Funk, Adam Nadeau, Savannah Ullyott

Critically Appraised Topics

This critically appraised topic (CAT) paper focuses on the impact of technology-based interventions in occupational therapy in daily functioning within older adults with cognitive deficits. When considering the components of this CAT, the theoretical framework was described, then a description of the population paired with a description of cognition and its components, followed by the types and use of technology-based interventions with adults, and the impact cognitive conditions and symptoms have on occupational performance.

Digital Clock Drawing As An Alzheimer's Disease Susceptibility Biomarker: Associations With Genetic Risk Score And Apoe In Older Adults, L I Thompson, M Cummings, S Emrani, David J. Libon, A Ang, C Karjadi, R Au, C Liu

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Alzheimer's disease (AD) is the leading cause of dementia in older adults, but most people are not diagnosed until significant neuronal loss has likely occurred along with a decline in cognition. Non-invasive and cost-effective digital biomarkers for AD have the potential to improve early detection.

OBJECTIVE: We examined the validity of DCTclockTM (a digitized clock drawing task) as an AD susceptibility biomarker.

DESIGN: We used two primary independent variables, Apolipoprotein E (APOE) ε4 allele carrier status and polygenic risk score (PRS). We examined APOE and PRS associations with DCTclockTM composite scores as dependent measures.

SETTING: We used existing data …

Uab Nursing - Fall 2024, University Of Alabama At Birmingham

UAB Nursing magazine

No abstract provided.

Baystate Medical Center Nursing Report - 2024, Joanne Miller Rn, Brenda Rocha Rn, Cno

Baystate Medical Center Nursing Report

Baystate Medical Center Nursing Report - 2024

2024-2025 Graduate Msn-Fnp Handbook, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2024-2025 Graduate Student Handbook for the Department of Nursing at Morehead State University.

Resilience And Compassion Fatigue Among Medical Nurses In Acute Care, Angela M. Vallier

Nursing Dissertations - Archive

Compassion fatigue impacts nurses of all backgrounds and specialties. This non-experimental, descriptive, correlational study design involved three research questions that examined medical registered nurses’ association between resilience and compassion fatigue. This study examined organizational factors, work-system factors, and individual factors that are influential to compassion fatigue and resilience among nurses working in general medicine units.

The Compassion Fatigue Short Scale® and Connor-Davidson Resilience Scale® were used to measure compassion fatigue and resilience among the participants in this study. The study included 98 registered nurses who worked in general medicine units in Southeast Texas. The results indicated a negative significant correlation …

Polypharmacy And Potentially Inappropriate Prescribing In Geriatric Population, Maryam Burney, Barry Brown, Victoria Nguyen, Garrett Furth, Ambreen I. Ahmed, Abigail Hulsizer

North Texas GME Research Forum 2024

Polypharmacy is a ubiquitous concern among patients, especially geriatric patients, who are at a higher risk of clinical burden. It is associated with an increase in healthcare costs, decreased functional status, and adverse drug events, contributing to geriatric syndromes, such as falls, cognitive decline, and urinary retention. Geriatric care is multi-tiered, requiring assistance and care from a thorough physician who is attune to the potential risks of medications that are commonly prescribed. Smaller communities, often with less resources and clinical providers and with an aging population, especially at the hospital setting, are vulnerable to oversights when it comes to medication …

Examining Effects Of Perceived Discrimination And Loneliness On Overall Health Outcomes In Black Americans, Apoorva Saravanan

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

On average, Black Americans suffer more from a wide range of diseases when compared to White Americans. The national mortality rate for Black Americans is also 24% higher than their White counterparts. Although there are multiple factors contributing to such disparities, one line of research provides strong evidence that negative health outcomes are more likely to occur in Black Americans who experience racial discrimination than those who experience no discrimination. A separate line of research also provides evidence that loneliness is a major health risk factor. In fact, prior research indicates that the experience of discrimination and loneliness are both …

A Multidisciplinary Approach To Identify Postoperative Delirium In Geriatric Patients Using A Brain Health Screening Tool, Ashlyn Mccartney

Graduate Theses, Dissertations, and Problem Reports (ETD)

Postoperative delirium (POD) is a common occurrence, effecting nearly 61% of the surgical population recovering from anesthesia. POD increases risk of morbidity and mortality leading to prolonged hospital length of stay by 0.8 to 7.3 days and increased costs by $1,551 to $23,698 (Masharaf et al., 2022; Sethi, 2021). An academic medical center in northern West Virginia (WV) lacks a structured practice/protocol to identify high risk patients and assess POD. An evidence-based solution was developed based on the PICO question: Does a multidisciplinary approach to perianesthetic care utilizing a brain health screening tool, compared to lack of a screening tool, …