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Articles 4441 - 4470 of 5990
Full-Text Articles in Entire DC Network
Miller To Receive Iwu’S School Of Nursing Distinguished Alumni Award, Hannah Dhue
Miller To Receive Iwu’S School Of Nursing Distinguished Alumni Award, Hannah Dhue
News and Events (Discontinued Series)
No abstract provided.
Perspectives Of Older Adults On Co-Management Of Low Back Pain By Doctors Of Chiropractic And Family Medicine Physicians: A Focus Group Study., Kevin J Lyons, Stacie A Salsbury, Maria A Hondras, Mark E Jones, Andrew A Andresen, Christine M Goertz
Perspectives Of Older Adults On Co-Management Of Low Back Pain By Doctors Of Chiropractic And Family Medicine Physicians: A Focus Group Study., Kevin J Lyons, Stacie A Salsbury, Maria A Hondras, Mark E Jones, Andrew A Andresen, Christine M Goertz
Department of Medical Genetics Faculty Papers
BACKGROUND: While older adults may seek care for low back pain (LBP) from both medical doctors (MDs) and doctors of chiropractic (DCs), co-management between these providers is uncommon. The purposes of this study were to describe the preferences of older adults for LBP co-management by MDs and DCs and to identify their concerns for receiving care under such a treatment model.
METHODS: We conducted 10 focus groups with 48 older adults who received LBP care in the past year. Interviews explored participants' care seeking experiences, co-management preferences, and perceived challenges to successful implementation of a MD-DC co-management model. We analyzed …
Inhibition Of Fas-Associated Death Domain-Containing Protein (Fadd) Protects Against Myocardial Ischemia/Reperfusion Injury In A Heart Failure Mouse Model., Qian Fan, Zheng M Huang, Matthieu Boucher, Xiying Shang, Lin Zuo, Henriette Brinks, Wayne Bond Lau, Jianke Zhang, J Kurt Chuprun, Erhe Gao
Inhibition Of Fas-Associated Death Domain-Containing Protein (Fadd) Protects Against Myocardial Ischemia/Reperfusion Injury In A Heart Failure Mouse Model., Qian Fan, Zheng M Huang, Matthieu Boucher, Xiying Shang, Lin Zuo, Henriette Brinks, Wayne Bond Lau, Jianke Zhang, J Kurt Chuprun, Erhe Gao
Department of Emergency Medicine Faculty Papers
AIM: As technological interventions treating acute myocardial infarction (MI) improve, post-ischemic heart failure increasingly threatens patient health. The aim of the current study was to test whether FADD could be a potential target of gene therapy in the treatment of heart failure.
METHODS: Cardiomyocyte-specific FADD knockout mice along with non-transgenic littermates (NLC) were subjected to 30 minutes myocardial ischemia followed by 7 days of reperfusion or 6 weeks of permanent myocardial ischemia via the ligation of left main descending coronary artery. Cardiac function were evaluated by echocardiography and left ventricular (LV) catheterization and cardiomyocyte death was measured by Evans blue-TTC …
The Stethoscoop, September 13, 2013, Mennonite College Of Nursing
The Stethoscoop, September 13, 2013, Mennonite College Of Nursing
The Stethoscoop (2013-2017)
The Stethoscoop is the newsletter for Mennonite College of Nursing students.
Predictors Of Cooperative And Externalizing Behaviors In Siblings Of Children With Disabilities, Christine Rae Platt
Predictors Of Cooperative And Externalizing Behaviors In Siblings Of Children With Disabilities, Christine Rae Platt
Theses and Dissertations
Objective: To examine whether caregiver burden, parenting style, and sibling relationships in families raising a child with a disability (CWD) predict cooperative and externalizing behaviors in typically-developing sibling (TDS). Methods: This correlational study included 189 families raising both a CWD and a TDS. Mothers and fathers completed self-report questionnaires on caregiver burden, sibling relationships, parenting style, and TDS cooperative and externalizing behaviors. Results: Authoritative parenting was positively associated with cooperative behaviors, whereas authoritarian parenting was positively associated with externalizing behaviors. Hierarchical regression revealed caregiver burden was a significant predictor of cooperative and externalizing behaviors; however, when parenting style was added …
Memory Training For Older Adults With Mild Cognitive Impairment, Charlotte A. Allsop, Dr. Barbara Heise
Memory Training For Older Adults With Mild Cognitive Impairment, Charlotte A. Allsop, Dr. Barbara Heise
Journal of Undergraduate Research
Dementia is manifested by a severely limited memory and performance of cognitive abilities. Mild Cognitive Impairment (MCI) is an early stage of memory loss which can later lead to Dementia. It has been proven that you can delay cognitive dysfunction, e.g. memory, by “training the brain” through various cognitive exercises. However, those with MCI are difficult to detect because their memory loss is subtle. The purpose of this study is to first, enhance MCI recognition in elderly individuals and second, to determine the efficacy of memory training in the community.
The Relationship Of Education On Geriatric Nurse Practitioners Frequency Of Providing Spiritual Care In Practice, Barbara Vincensi
The Relationship Of Education On Geriatric Nurse Practitioners Frequency Of Providing Spiritual Care In Practice, Barbara Vincensi
Faculty Presentations
No abstract provided.
Resourcefulness, Positive Cognitions, Relocation Controllability, And Relocation Adjustment Among Older People: A Cross Sectional Study Of Cultural Differences, Abir K. Bekhet, Jaclene Zauszniewski
Resourcefulness, Positive Cognitions, Relocation Controllability, And Relocation Adjustment Among Older People: A Cross Sectional Study Of Cultural Differences, Abir K. Bekhet, Jaclene Zauszniewski
College of Nursing Faculty Research and Publications
Background. The population of older people in both the United States and Egypt is expected to double by the year 2030. With ageing, chronic illnesses increase and many older people need to relocate to retirement communities. Research has shown that positive cognitions and resourcefulness are positively correlated with adaptive functioning and better adjustment.
Aims and objectives. The purpose of this study was to examine and compare relocation controllability, positive cognitions, resourcefulness and relocation adjustment between American and Egyptian older people living in retirement communities. The purpose of this cultural comparison is to gain insight into influencing factors in each culture …
Psychometric Assessment Of The Depressive Cognition Scale In Caregivers Of Persons With Dementia, Abir K. Bekhet, Jaclene Zauszniewski
Psychometric Assessment Of The Depressive Cognition Scale In Caregivers Of Persons With Dementia, Abir K. Bekhet, Jaclene Zauszniewski
College of Nursing Faculty Research and Publications
Caregivers of persons with dementia are prone to depression. Early identification of cognitive depressive symptoms is important to prevent the development of clinical depression. The Depressive Cognition Scale (DCS) can be used for early detection, but the scale's psychometrics have not been tested in caregivers of persons with dementia. In this study, 80 caregivers of persons with dementia completed the eight-item DCS and measures of caregiver burden and resourcefulness. A Cronbach's alpha of .88 indicated internal consistency. Construct validity was supported by significant correlations with caregiver burden (r = .40; p < .001) and resourcefulness (r = –.54; p < .001). Principal components factor analysis resulted in two factors in which five items loaded cleanly on one factor and two items have cross-loadings. Because prior factor analysis in previous studies resulted in one factor, we did confirmatory factor analysis in which we forced the items on one factor. All the items loaded on the single factor and the amount of variance explained was 55.99%. The findings suggest the DCS is useful for early detection of depression in caregivers of persons with dementia.
Use Of Participant-Generated Photography In A Research Contribution Course, Maryellen Thompson
Use Of Participant-Generated Photography In A Research Contribution Course, Maryellen Thompson
The Open Journal of Occupational Therapy
This paper describes the use of small, qualitative studies focused on interviews done with participant-generated photographs as an effective and efficient way of teaching research to entry-level masters students. A comparison of using time-use diaries vs. participant-generated photography is presented to explicate the research process and demonstrate the advantages of using photography, including ease of data collection and data sharing. Over a three-year period of using participant-generated photographs as a guide for semi-structured interviews, students have consistently expressed enjoyment of the research process and increased empathy with their research participants.
Cardiac Fibroblast-Dependent Extracellular Matrix Accumulation Is Associated With Diastolic Stiffness In Type 2 Diabetes., Kirk R. Hutchinson, C. Kevin Lord, T. Aaron West, James A. Stewart
Cardiac Fibroblast-Dependent Extracellular Matrix Accumulation Is Associated With Diastolic Stiffness In Type 2 Diabetes., Kirk R. Hutchinson, C. Kevin Lord, T. Aaron West, James A. Stewart
CAS Publications
Cardiovascular complications are a leading cause of death in patients with type 2 diabetes mellitus (T2DM). Diastolic dysfunction is one of the earliest manifestations of diabetes-induced changes in left ventricular (LV) function, and results from a reduced rate of relaxation and increased stiffness. The mechanisms responsible for increased stiffness are not completely understood. Chronic hyperglycemia, advanced glycation endproducts (AGEs), and increased levels of proinflammatory and profibrotic cytokines are molecular pathways known to be involved in regulating extracellular matrix (ECM) synthesis and accumulation resulting in increased LV diastolic stiffness. Experiments were conducted using a genetically-induced mouse model of T2DM generated by …
Paws With A Purpose: Evidence Supporting The Use Of Animal Assisted Therapy To Improve Quality Of Life In Adults With Psychiatric Diagnoses, Julia Andraka, Lacey Brinser, Kelly D'Ambrosio, Jordan Justice, Elizabeth Rugen
Paws With A Purpose: Evidence Supporting The Use Of Animal Assisted Therapy To Improve Quality Of Life In Adults With Psychiatric Diagnoses, Julia Andraka, Lacey Brinser, Kelly D'Ambrosio, Jordan Justice, Elizabeth Rugen
Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)
Approximately 62.7 million Americans have a psychiatric diagnosis, including Alzheimer’s disease and mental disorders1,6. Adults who are diagnosed with these conditions experience a variety of limitations, including decreased quality of life4. Occupational Therapy (OT) has been shown to be an effective treatment to increase quality of life in adults with psychiatric diagnoses3. Occupational therapists working within the mental health field often need to use creative and innovative approaches to motivate their clients, including Animal-assisted therapy (AAT). AAT is a unique intervention approach that has the potential to improve a person’s emotional, physical, cognitive and …
Pattern Of Emergency Department Visits By Elderly Patients: Study From A Tertiary Care Hospital, Karachi, Jabeen Fayyaz, Munawar Khursheed, Mohammed Umer Mir, Uzma Rahim Khan
Pattern Of Emergency Department Visits By Elderly Patients: Study From A Tertiary Care Hospital, Karachi, Jabeen Fayyaz, Munawar Khursheed, Mohammed Umer Mir, Uzma Rahim Khan
Department of Emergency Medicine
Background
Worldwide the proportion of elderly people in the population is increasing. Currently in Pakistan 7.3 million people (5.6% of total population) are more than 60 years old. This age shift has emerged as an important health issue and is associated with an increased utilization of emergency services by the elderly. We carried out this study to assess the pattern of elderly patients (>60 years) who visit emergency departments in comparison to young adults (18–60 years).
Methods
Data was collected retrospectively of patients aged 18 years or more who visited the Emergency Department (ED) of Aga Khan University Hospital, …
Suicide Screening In Primary Care With Patients Diagnosed With Depression, Lori Duke, Cindy Patrick
Suicide Screening In Primary Care With Patients Diagnosed With Depression, Lori Duke, Cindy Patrick
MSN Research Projects
The purpose of this study was to evaluate healthcare providers' compliance with the recommended 2009 ACCF/AHA guidelines for monitoring routine serum potassium levels in heart failure patients.
Healthcare Providers Monitoring Of Serum Potassium Levels In The Treatment Of Heart Failure, Lori Duke, Cindy Patrick
Healthcare Providers Monitoring Of Serum Potassium Levels In The Treatment Of Heart Failure, Lori Duke, Cindy Patrick
MSN Research Projects
The purpose of this study was to evaluate healthcare providers' compliance with the recommended 2009 ACCF/AHA guidelines for monitoring routine serum potassium levels in heart failure patients.
Effects Of Prior Acute Exercise On Circulating Cytokine Concentration Responses To A High-Fat Meal, Josef Brandauer, Rian Q. Landers-Ramos, Nathan T. Jenkins, Espen E. Spangenburg, James M. Hagberg, Steven J. Prior
Effects Of Prior Acute Exercise On Circulating Cytokine Concentration Responses To A High-Fat Meal, Josef Brandauer, Rian Q. Landers-Ramos, Nathan T. Jenkins, Espen E. Spangenburg, James M. Hagberg, Steven J. Prior
Health Sciences Faculty Publications
High-fat meal consumption alters the circulating cytokine profile and contributes to cardiometabolic diseases. A prior bout of exercise can ameliorate the triglyceride response to a high-fat meal, but the interactive effects of exercise and high-fat meals on cytokines that mediate cardiometabolic risk are not fully understood. We investigated the effects of prior exercise on the responses of circulating tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), IL-8, leptin, retinol-binding protein 4 (RBP4), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) to a high-fat meal. Ten healthy men were studied before …
The Effectiveness Of The Learning To Breathe Program On Adolescent Emotion Regulation, Stacie M. Metz, Jennifer L. Frank, Diane K. Reibel, Todd Cantrell, Richard Sanders, Patricia C. Broderick
The Effectiveness Of The Learning To Breathe Program On Adolescent Emotion Regulation, Stacie M. Metz, Jennifer L. Frank, Diane K. Reibel, Todd Cantrell, Richard Sanders, Patricia C. Broderick
Marcus Institute of Integrative Health Faculty Papers
This study assessed the effectiveness of a mindfulness-based program, Learning to BREATHE, on adolescent emotion regulation. Participants included 216 regular education public high school students with pretest and posttest data participating in the program or instruction-as-usual comparison condition. Program participants reported statistically lower levels of perceived stress and psychosomatic complaints and higher levels of efficacy in affective regulation. Program participants also evidenced statistically larger gains in emotion regulation skills including emotional awareness, access to regulation strategies, and emotional clarity. These findings provide promising evidence of the effectiveness of Learning to BREATHE on the development of key social-emotional learning skills.
Medicaid Expansion, Long-Term Care Financing In Retirement States And The Post World War Ii Birth Cohort, Toni P. Miles
Medicaid Expansion, Long-Term Care Financing In Retirement States And The Post World War Ii Birth Cohort, Toni P. Miles
Center for Policy Research
This policy brief contains a formal consideration of ideas discussed during a presentation to the 2012 Syracuse Seminar on Aging. Like most briefs, it will appeal to policy makers and academics craving detailed demographic, fiscal and policy data. Before diving into this brief, I would encourage readers to view the presentation video (available at http://www.youtube.com/ watch?v=bsv8K7DdJFY). As you will see, the seminar was informal and the discussion was wide ranging. In contrast, this brief focuses on limitations faced by states as they finance longterm care. It is primarily concerned with the Medicaid expansion and growing need for care as the …
Successful Aging And Creativity : An Investigation On Functional Status And Psychological Wellbeing In Older Adults, Mirie E. Levy
Successful Aging And Creativity : An Investigation On Functional Status And Psychological Wellbeing In Older Adults, Mirie E. Levy
Loma Linda University Electronic Theses, Dissertations & Projects
Objectives: While the literature supports the maintenance of functional status as integral to successful aging, the relationship of creativity on functional status has received little attention. Creativity has been associated with health and aging in the research but only a small number of studies have examined creativity interventions to enhance functional status and boost psychological wellbeing.
Methods: A pretest-posttest quasi-experimental design was used to investigate an 8-week creativity intervention on functional status and psychological wellbeing in older adults. Sample subjects were 92 men and women all over age 60. A series of two-way mixed ANOVAs measured differences between treatment and …
"Who Would Have Thought, With A Diagnosis Like This, I Would Be Happy?": Portraits Of Perceived Strengths And Resources In Early-Stage Dementia, Jutta Elisabeth Ataie
"Who Would Have Thought, With A Diagnosis Like This, I Would Be Happy?": Portraits Of Perceived Strengths And Resources In Early-Stage Dementia, Jutta Elisabeth Ataie
Dissertations and Theses
This study used photovoice methodology to explore how people with early-stage dementia use their perceived strength and resources to cope with the illness. Purposive sampling was used to recruit participants. Thirteen women and seven men age 57 to 90 (mean 73.4) with MMSE scores ranging from 20 to 28 (mean 25.6) participated in the project. Participants were provided with a disposable camera and invited to take photographs relevant to their well-being. The photographs provided the means for participants to take the lead in dialogue sessions about their coping response.
Grounded theory analysis revealed that initially, early-stage dementia precipitated a disruption …
The Historical, Political, Social, And Individual Factors That Have Influenced The Development Of Aging And Disability Resource Centers And Options Counseling, Sheryl Dejoy Elliott
The Historical, Political, Social, And Individual Factors That Have Influenced The Development Of Aging And Disability Resource Centers And Options Counseling, Sheryl Dejoy Elliott
Dissertations and Theses
This thesis reports on the perspectives and experiences of policymakers, advocates, agency supervisors, and experts in the field of gerontology, about the development of Aging and Disability Resource Centers (ADRC) programs and Options Counseling (OC). By examining the foundations upon which ADRCs and OC are built, this study sought to inform future research about the effectiveness of existing practice, increase understanding of best practices, and clarify whether these emerging services are accomplishing original goals.
ADRCs and OC intend to address long-term care issues and healthcare needs by providing a single entry point to the social service system. ADRCs offer information, …
Cardiovascular Health: Associations With Race-Ethnicity, Nativity, And Education In A Diverse, Population-Based Sample Of Californians, Georgiana Bostean, Christian K. Roberts, Catherine M. Crespi, Michael Prelip, Anne Peters, Thomas R. Belin, William J. Mccarthy
Cardiovascular Health: Associations With Race-Ethnicity, Nativity, And Education In A Diverse, Population-Based Sample Of Californians, Georgiana Bostean, Christian K. Roberts, Catherine M. Crespi, Michael Prelip, Anne Peters, Thomas R. Belin, William J. Mccarthy
Sociology Faculty Articles and Research
Purpose—This study examined how race-ethnicity, nativity, and education interact to influence disparities in cardiovascular (CV) health, a new concept defined by the American Heart Association (AHA). We assessed whether race-ethnicity and nativity disparities in CV health vary by education, and whether the foreign-born differ in CV health from their US-born race-ethnic counterparts with comparable education.
Methods—We used data from the 2009 California Health Interview Survey to determine the prevalence of optimal CV health metrics (based on selected AHA guidelines) among adults ages 25 and over (n = 42,014). We examined the interaction between education and ethnicity-nativity, comparing predicted …
Aboriginal And Non-Aboriginal Students Learn About Natural Health Products From Different Information Sources, Sarah O. Alkholy, Samiah N. Alqahtani, Audrey Cochrane, Maria Pontes Ferreira, Fidji Gendron
Aboriginal And Non-Aboriginal Students Learn About Natural Health Products From Different Information Sources, Sarah O. Alkholy, Samiah N. Alqahtani, Audrey Cochrane, Maria Pontes Ferreira, Fidji Gendron
Nutrition and Food Science Faculty Research Publications
Natural health products (NHPs) include naturally derived botanical and nonbotanical products. Past research indicates a high prevalence of NHPs use amongst adults in the United States and Canada but does not clearly characterize NHPs use amongst students, ethnic variations of such use, or how users learn about NHPs. We hypothesize that there is a difference between Aboriginal and non-Aboriginal students in how they learn about NHPs. To investigate this question, we conducted a cross-sectional study at First Nations University of Canada and the University of Regina, Saskatchewan, Canada, during the fall of 2011. Aboriginal (n=214) and non-Aboriginal (n=749) students participated …
Analysis Of Community-Based Accumulation Of Home Medications (Caches) Found At Death Scenes In Davidson County, Tennessee, Carrie E. Plummer
Analysis Of Community-Based Accumulation Of Home Medications (Caches) Found At Death Scenes In Davidson County, Tennessee, Carrie E. Plummer
Theses and Dissertations (ETD)
Introduction: Stockpiling of unused medications by community-dwelling individuals results in Community-based ACcumulation of Home mEdicationS (CACHES). CACHES place the individual, health care and justice system, and ecosystem at risk for adverse outcomes including: a) diversion of prescription medications by friends and family, b) pediatric poisonings, c) adverse drug events, d) increased criminal justice system costs related to prescription drug abuse, e) increased health care costs, and f) pollution of local water supplies via improper medication disposal. This study explores the relationship among individual risk factors (gender, race, age, comorbid conditions), geographical location, health care risk factors (number of prescribers and …
Hip Fracture Surgery: Does Type Of Anesthesia Matter?, Rizwan Haroon Rashid, Adil Aijaz Shah, Amarah Shakoor, Shahryar Noordin
Hip Fracture Surgery: Does Type Of Anesthesia Matter?, Rizwan Haroon Rashid, Adil Aijaz Shah, Amarah Shakoor, Shahryar Noordin
Department of Surgery Docs
Background: Hip fracture surgery is a common procedure, and the geriatric population with its multiple comorbid conditions is at most at risk of developing anesthesia-related complications. Data on the impact of type anesthesia on postoperative morbidity and mortality is limited.The effects of regional and general anesthesia on postoperative outcomes need to be clearly elucidated.
Methods: In this study, all patients who underwent dynamic hip screw (DHS) fixation for intertrochanteric fractures, between January 2005 and December 2010, at the Aga Khan University Hospital, were included. Patients were divided into two groups; group A included those patients who received general anesthesia, and …
2012-2013 Department Of Family Medicine Scholarly Activity Report, Quillen College Of Medicine, East Tennessee State University
2012-2013 Department Of Family Medicine Scholarly Activity Report, Quillen College Of Medicine, East Tennessee State University
Quillen College of Medicine Scholarly Activity Reports
No abstract provided.
Considering Positive Psychology Constructs Of Life Satisfaction And School Connectedness When Assessing Symptoms Related To Attention-Deficit/Hyperactivity Disorder, Emily B. Mancil, Jason M. Bird, Mike Lyons, Kathryn Van Eck, Bradley H. Smith
Considering Positive Psychology Constructs Of Life Satisfaction And School Connectedness When Assessing Symptoms Related To Attention-Deficit/Hyperactivity Disorder, Emily B. Mancil, Jason M. Bird, Mike Lyons, Kathryn Van Eck, Bradley H. Smith
Journal of Human Sciences and Extension
Children and adolescents diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) demonstrate significant difficulty with academic and behavioral functioning. This, in turn, can lead to lower educational attainment and vocational achievement, which has serious long-term consequences and costs to individuals and society (Barkley, 2002, 2006; Mannuzza, Klein, Bessler, Malloy, & LaPadula, 1993). Researchers from a positive psychology framework suggest that ADHD symptoms (i.e., inattention, hyperactivity/impulsivity) alone may not fully explain academic impairment (Diener, Scollon, & Lucas, 2004). From the standpoint of positive psychology, life satisfaction and school connectedness are important constructs that examine positive life functioning; however, they have been understudied, particularly in …
"A Day In The Life:" A Simulated Experience, Melinda Hermanns, Narisa Waldo, Mary Luanne Lilly
"A Day In The Life:" A Simulated Experience, Melinda Hermanns, Narisa Waldo, Mary Luanne Lilly
Nursing Faculty Publications and Presentations
An experiential learning activity titled, "A Day in the Life" was implemented with nineteen baccalaureate nursing students in order to achieve a holistic understanding of the challenges faced by persons living with Schizophrenia and a physical disability, such as a fracture in an upper extremity or a visual impairment. The role play simulation required that students interact with public transportation and community resources, while assuming the role of a person with Schizophrenia and a physical disability. Using a qualitative descriptive methodology, reflective journals, aesthetic expressions, and post conference discussions about "A Day in the Life" were reviewed and analyzed by …
The Effect Of Age On Speech Motor Performance During Divided Attention, Dallin J. Bailey
The Effect Of Age On Speech Motor Performance During Divided Attention, Dallin J. Bailey
Theses and Dissertations
The present study examined the divided attention effects of three non-speech tasks on concurrent speech motor performance. These tasks targeted linguistic, cognitive, and manual motor activity. Participants included 60 healthy adults separated into three different age groups of twenty participants each: college-age (20s), middle-aged (40s), and older adults (60s). Each participant completed a speech task once in isolation and once concurrently with each of the three non-speech tasks: a semantic decision task, a quantitative comparison task, and a manual motor task. The non-speech tasks were also performed in isolation. The speech task involved repeating a target phrase each time a …
Relationship Between Serum And Brain Carotenoids, Α-Tocopherol, And Retinol Concentrations And Cognitive Performance In The Oldest Old From The Georgia Centenarian Study, Elizabeth J. Johnson, Rohini Vishwanathan, Mary Ann Johnson, Dorothy B. Hausman, Adam Davey, Tammy M. Scott, Robert C. Green, L. Stephen Miller, Marla Gearing, John Woodard, Peter T. Nelson, Hae-Yun Chung, Wolfgang Schalch, Jonas Wittwer, Leonard W. Poon
Relationship Between Serum And Brain Carotenoids, Α-Tocopherol, And Retinol Concentrations And Cognitive Performance In The Oldest Old From The Georgia Centenarian Study, Elizabeth J. Johnson, Rohini Vishwanathan, Mary Ann Johnson, Dorothy B. Hausman, Adam Davey, Tammy M. Scott, Robert C. Green, L. Stephen Miller, Marla Gearing, John Woodard, Peter T. Nelson, Hae-Yun Chung, Wolfgang Schalch, Jonas Wittwer, Leonard W. Poon
Sanders-Brown Center on Aging Faculty Publications
Oxidative stress is involved in age-related cognitive decline. The dietary antioxidants, carotenoids, tocopherols, and vitamin A may play a role in the prevention or delay in cognitive decline. In this study, sera were obtained from 78 octogenarians and 220 centenarians from the Georgia Centenarian Study. Brain tissues were obtained from 47 centenarian decedents. Samples were analyzed for carotenoids, α-tocopherol, and retinol using HPLC. Analyte concentrations were compared with cognitive tests designed to evaluate global cognition, dementia, depression and cognitive domains (memory, processing speed, attention, and executive functioning). Serum lutein, zeaxanthin, and β-carotene concentrations were most consistently related to better cognition …