Digital Commons Network^™

The Role Of Nadph Oxidase 2 (Nox2) In High-Fat Diet-Induced Adiposopathy And Brain Dysfunction In A Mouse Model, Jennifer Kathleen Pepping

LSU Master's Theses

Obesity can have numerous detrimental consequences, namely metabolic syndrome, type 2 diabetes, cardiovascular disease, cancer, and Alzheimer’s disease. The pathogenesis and physiologic consequences of obesity are unknown, but they are often associated with increased inflammation and oxidative stress in both the body and in the brain. One factor that has been implicated in causing inflammation associated with a high fat diet is the enzyme NADPH oxidase, or NOX, specifically the subunit NOX2. Two studies were performed in order to assess the effects of a high fat diet in combination with a universal NOX2 deficiency and a NOX2 deficiency targeted to …

Reference Ranges And Association Of Age And Lifestyle Characteristics With Testosterone, Sex Hormone Binding Globulin, And Luteinizing Hormone Among 1166 Western Chinese Men, Xubo Shen, Ruifeng Wang, Na Yu, Yongjun Shi, Honggang Li, Chengliang Xiong, Yan Li, Ellen M. Wells, Yuanzhong Zhou

School of Health Sciences Faculty Publications

Decreased total testosterone (TT) is the recommended metric to identify age-related hypogonadism. However, average TT and the extent to which it varies by age, can vary substantially among different populations. Population-specific reference ranges are needed to understand normal versus abnormal TT levels. Therefore, the goal for this study was to describe androgen concentrations and their correlates among Western Chinese men. We completed a population-based, cross-sectional study including 227 young adults (YA) (20–39 years) and 939 older adults (OA) (40–89 years). We measured TT, sex-hormone binding globulin (SHBG), luteinizing hormone (LH), testosterone secreting index (TSI), and calculated free testosterone (cFT). Reference …

A Qualitative Pilot Study Of Aging Women’S Physical Activity Experiences In One University Fitness And Wellness Center, Alexis Hobbs

Online Theses and Dissertations

Physical inactivity is one of the driving risk factors for developing health problems such as obesity, diabetes, and cardiovascular diseases (World Health Organization, 2003). The prevalence of these diseases increases with the aging process, which renders participation in physical activity crucial among the aging population. There is strong evidence that physical activity reduces the risk of these health disparities and disabilities (Young & Dinan, 2005), however despite these well-documented benefits, aging women still remain sedentary. This study examined the phenomenon of women 55 years of age or older and their lived experiences of participating in physical activity within a university …

The Lived Experience Of Informal Caregivers Of Chronic Stroke Patients, Ann Snider Wigginton

Online Theses and Dissertations

The purpose of this phenomenological study is to contribute to the literature surrounding stroke-survivor caregivers and to understand the caregivers’ perspective on leisure participation and quality of life. Four caregivers of clients with chronic stroke were recruited for the study via convenience sampling. Participants were audio-recorded during a semi-structured interview lasting 60-80 minutes. The interview guide was consistent across participants and included open-ended questions about the caregiver’s leisure participation and quality of life. Recorded data was transcribed and in-vivo coding was completed. Eight categories were developed from the identified codes and narrowed into primary meaning units: role shift, loss of …

Role Of Community Participation In Improving Quality Of Life In Clients With Dementia And Their Caregivers, Mridula Dhamija

Online Theses and Dissertations

Aim: The purpose of this study was to investigate the effects on quality of life for clients with dementia and their caregivers by participating in a community program, the Memory Café.

Method: In this qualitative, cross case study, the Marwit Meser Caregiver Grief Inventory (MM-CGI) was given to caregiver. Data collection was done by interviewing the participants; there was a main question with follow- up questions as needed. All the interviews were audiotaped and transcribed followed by primary and secondary coding. Shortlisting of categories resulted in emergence of themes which were common across cases and unique to each case.

Results: …

Motives For Participation In Triathlons Among Midlife To Older Black Women: A Mixed Method Study, Candace Brown

Theses and Dissertations

BACKGROUND: Research has established the positive link between physical activity and its impact on health among adults. Generally, as people get older, they are less likely to be active. Black women comprise 13% of the women in the US but constitute 52% of women who are inactive. Existing articles on exercise motivation among Black women have generally assessed sedentary individuals. Little research has examined the motivations to exercise among physically active Black women. METHODS: Guided by the regulators of the Self Determination Theory, the 56 item Motivations of Marathoners Scales for Triathletes (MOMS-T) was used to assess the motives of …

The Effect Of Nurse Dose On Breastfeeding Exclusivity - A Patient Level Analysis, Gwen Moreland

DNP Projects

Background: Breastfeeding is strongly associated with health benefits for children and their mothers. Despite this knowledge, breastfeeding rates in the United States have increased only slightly. Current research examines the relationship between nurse characteristics and patient outcomes in adult intensive care and acute care settings. To date there is very limited research examining nurse variables and outcomes in women and children, and very little knowledge regarding the characteristics of the nurse in relation to patient’s breastfeeding success.

Purpose: The purpose of this practice inquiry project was to evaluate the relationship between the attributes of nurse dose and the immediacy and …

Do Call-Backs Help Patients Post Stroke, Taylor E. Clark

DNP Projects

Aim and Objective: To determine if the implementation of a post-discharge call-back intervention for patients discharged home from the hospital after stroke was associated with a decrease in 30-day readmissions and improved patient satisfaction.

Background: Stroke is a leading cause of death and disability in the United States (American Stroke Association, 2015). Several studies have examined various post-discharge interventions, including a call to the patient and/or family after their return home, to determine the benefit to patients, if any (Zolfaghari, Mousavifar, Pedram & Haghani (2012). Understanding and anticipating patient needs and removing barriers post-stroke may decrease readmission rates …

Need Assessment For Early Identification Of Delirium In Post-Operative Patients In Intensive Care Unit, Raji Rajan

DNP Projects

Background: Delirium is an acute dysfunction of cognition, memory, and attention resulting in changes in perception, mood, and activity. Delirium is associated with increased length of hospital stay, prolonged mechanical ventilator days, increased mortality rate, and a higher number of discharge disposals to rehabilitation centers. The purpose of the study is to assess the current practice in delirium assessment and management strategies among postoperative patients in Intensive Care Units.

Methods: A retrospective medical record review was conducted in postoperative patients admitted to Norton Women’s and Kosair Children Hospital between January 2015 and December 2015. Postoperative delirium was diagnosed in compliance …

Beers Medication: Empowering The Elderly Through Education, Amanda J. Parker

DNP Projects

The elderly population (those aged 65 years and older) has an increased risk of experiencing adverse effects from their prescribed medications. These adverse effects are due to many reasons, one being changes that naturally occur in the aging body, such as diminished kidney function or decreased gastrointestinal motility. This project explores the prescribing practices of one primary care practice setting. Specifically, this project sought to determine the number of patients in a primary care practice who were prescribed medications on the Beers list and whether or not the patients received education on adverse effects. The results concluded the most frequently …

Hydrogen Peroxide Induced Loss Of Heterozygosity Correlates With Replicative Lifespan And Mitotic Asymmetry In Saccharomyces Cerevisiae, Emine Guven, Lindsay A. Parnell, Erin D. Jackson, Meighan Parker, Nilin Gupta, Jenny Rodrigues, Hong Qin

Scholarly Works

Cellular aging in Saccharomyces cerevisiae can lead to genomic instability and impaired mitotic asymmetry. To investigate the role of oxidative stress in cellular aging, we examined the effect of exogenous hydrogen peroxide on genomic instability and mitotic asymmetry in a collection of yeast strains with diverse backgrounds. We treated yeast cells with hydrogen peroxide and monitored the changes of viability and the frequencies of loss of heterozygosity (LOH) in response to hydrogen peroxide doses. The mid-transition points of viability and LOH were quantified using sigmoid mathematical functions. We found that the increase of hydrogen peroxide dependent genomic instability often occurs …

Essays On Healthy Aging From The Perspective Of A Health Production Function, Nasim Baghban Ferdows

Wayne State University Dissertations

This dissertation examines the determinants of healthy aging among older adults using Grossman’s framework of a health production function. Healthy aging is produced using a variety of inputs, including some determined in early life, such as health and socioeconomic status as a child, others determined in young adulthood, such as education, others determined in mid-life, such as household wealth, and still others determined in later-life, such as current health habits. A production function for healthy aging is estimated using nationally representative data from the 2010 Health and Retirement Study on non-institutionalized seniors, and positing a simultaneous equations mediation model, recognizing …

Models For Community Based Day Care For Older People: A Narrative Review, Caroline Bulsara, Christopher Etherton-Beer, Rosemary Saunders

Nursing Papers and Journal Articles

Objectives: Older Australians are choosing to live within the community and there are a number of initiatives to enable this sector of the population to do so for longer. In an effort to ensure that they remain both physically and psychologically engaged, one initiative has been to provide community based day care (CBDC). Method: A narrative review was undertaken through searching MEDLINE, CINAHL Plus, Scopus and AgeInfo using keywords related to facility related, target group related and purpose/program of CBDC services. Results: Results indicated that there is a much research investigating different approaches but little consensus regarding the optimal delivery …

Large Reductions Are Possible In Older Driver Crashes At Intersections, Siby Samuel, Yusuke Yamani, Danald L. Fisher

Psychology Faculty Publications

Among all crash types, the largest percentage of older driver fatalities occur at intersections. Many explanations have been offered for older drivers' increased risks of crashing at intersections; however, only recently was it determined that older drivers were much less likely to glance for latent threats after entering an intersection than middle-aged drivers. In response, training programmes were designed to increase the frequency of such glances. The programmes have proven effective, doubling the frequency of these glances for up to a period of two years post-training. The programmes take only an hour to administer and are not directly targeted at …

Concept Analysis: Music Therapy, Carolyn J. Murrock, Abir K. Bekhet

College of Nursing Faculty Research and Publications

Down through the ages, music has been universally valued for its therapeutic properties based on the psychological and physiological responses in humans. However, the underlying mechanisms of the psychological and physiological responses to music have been poorly identified and defined. Without clarification, a concept can be misused, thereby diminishing its importance for application to nursing research and practice. The purpose of this article was for the clarification of the concept of music therapy based on Walker and Avant’s concept analysis strategy. A review of recent nursing and health-related literature covering the years 2007–2014 was performed on the concepts of music, …

Walking-Induced Fatigue Leads To Increased Risk In Older Adults, S. Morrison, S. R. Colberg, H. K. Parson, S. Neumann, R. Handel, E. J. Vinik, J. Paulson, A. I. Vinik

Rehabilitation Sciences Faculty Publications

Background- For older adults, falls are a serious health problem, with more than 30% of people older than 65 suffering a fall at least once a year. One element often overlooked in the assessment of falls is whether a person's balance, walking ability, and overall falls risk is affected by performing activities of daily living such as walking.

Objective- This study assessed the immediate impact of incline walking at a moderate pace on falls risk, leg strength, reaction time, gait, and balance in 75 healthy adults from 30 to 79 years of age. Subjects were subdivided into 5 equal groups …

Concept Analysis: Music Therapy, Carolyn J. Murrock, Abir K. Bekhet

College of Nursing Faculty Research and Publications

Down through the ages, music has been universally valued for its therapeutic properties based on the psychological and physiological responses in humans. However, the underlying mechanisms of the psychological and physiological responses to music have been poorly identified and defined. Without clarification, a concept can be misused, thereby diminishing its importance for application to nursing research and practice. The purpose of this article was for the clarification of the concept of music therapy based on Walker and Avant's concept analysis strategy. A review of recent nursing and health-related literature covering the years 2007–2014 was performed on the concepts of music, …

Development Of A Video-Based Education And Process Change Intervention To Improve Advance Cardiopulmonary Resuscitation Decision-Making, Nicholas Waldron, Clare V. Johnson, P Saul, Waldron Heidi, Jeffrey C. Chong, Anne-Marie Hill, Barbara Hayes

Medical Papers and Journal Articles

Background: Advance cardiopulmonary resuscitation (CPR) decision-making and escalation of care discussions are variable in routine clinical practice. We aimed to explore physician barriers to advance CPR decision-making in an inpatient hospital setting and develop a pragmatic intervention to support clinicians to undertake and document routine advance care planning discussions.

Methods: Two focus groups, which involved eight consultants and ten junior doctors, were conducted following a review of the current literature. A subsequent iterative consensus process developed two intervention elements: (i) an updated ‘Goals of Patient Care’ (GOPC) form and process; (ii) an education video and resources for teaching advance CPR …

Effectiveness Of A Service Learning Model With Allied Health Assistant Students In Aged Care, D Zulch, R Saunders, J Peters, J Quinlivan

Medical Papers and Journal Articles

This mixed methods audit explores the impact of a student learning activity involving service learning. As part of a vocational course in the Academy of Health Sciences at the West Coast Institute, Allied Health Assistant (AHA) students participated in a service learning program focused on work-based learning in residential aged care. Students delivered a therapy program for residents at the facility. Students completed validated evaluation questionnaires on conclusion of study. Of 121 students completing the audit, 91% thought the experience challenged their way of thinking. Only 2% disagreed with this concept. A majority of students (93%) reported the experience interesting …

Experiencing The Death Of A Formerly Abusive Parent, Heather Spence

Antioch University Dissertations & Theses

It is well documented that approximately 25–33% of children experience abuse, many of those at the hands of a primary caretaker. Within the literature on child maltreatment, there exists a paucity of research about the long-term effects of early maltreatment on adult attachments with the previous abuser, including the experiences of adults who experience the death of their previous caretakers. Additionally, most of the research on grief and bereavement assumes positive affect for the deceased by survivors. This dissertation is an in-depth examination of five adults, aged 50–70 years old, who experienced the recent death of a parent or stepparent …

The Happy Boomer: Baby Boomer Life Satisfaction Through Affect And Feeling Of Belonging, Brooke Christina-Marie Massey

Antioch University Dissertations & Theses

The age cohort of 65 years and older is a growing population. It is part of the group referred to as Baby Boomers, the generation born between the years 1946-1964. It will be the largest population to reach late adulthood to date. In the United States alone, the Baby Boomer cohort is expected to reach 70 million by 2030. In response to this growing elderly population much research has been conducted on Baby Boomer quality of life issues. Such research uncovered the phenomenon known as the well-being paradox. The well-being paradox refers to the findings that older adults' life satisfaction …

Sleep Quality And Factors Affecting Sleep In Elderly Patientswith Rheumatoid Arthritis In Turkey, Seda Pehli̇van, Ayfer Karadakovan, Yavuz Pehli̇van, Ahmet Mesut Onat

Turkish Journal of Medical Sciences

Background/aim: Sleep disorders are more common in people with rheumatoid arthritis (RA). We aimed to determine the sleep quality in adult and elderly people with RA and the factors associated with sleep disorders in each group. Materials and methods: The study was conducted with 182 patients (83 elderly and 99 adult patients) diagnosed with RA. Data were collected through a patient identification form including sociodemographic and disease characteristics. The Health Assessment Questionnaire (HAQ) and Pittsburg Sleep Quality Index (PSQI) were used to assess quality of life and sleep. Results: The mean PSQI scores of the elderly group were lower than …

Evaluating The Impact Of A Falls Prevention Community Of Practice In A Residential Aged Care Organisation, Jacqueline Francis-Coad

Theses

Falls in the residential aged care (RAC) sector are a global concern with humanitarian and economic consequences. Reducing falls using a multifactorial approach involving multidisciplinary staff is recommended, but it is not clear how RAC organisations in Australia can achieve this in a resource constrained environment. One potential solution is to develop a sustainable means of addressing falls prevention from within an organisation, creating a forum for staff to share ideas, expertise and achieve goals in a community of practice (CoP). The purpose of this research was to evaluate the impact of a falls prevention CoP on falls outcomes in …

The Impact Of Peer-Led Falls Prevention Education On Community-Dwelling Older Adults: A Mixed Methods Evaluation, Linda Khong

Theses

Older adults are not optimally engaged in falls prevention strategies. Peer education may be an approach to improving engagement and uptake of falls prevention strategies by community-dwelling older adults. However, empirical research regarding this approach has been inconclusive. Accordingly, the primary aim of this research was to design a peer-led falls prevention education program and evaluate its impact on community-dwelling older adults’ beliefs, knowledge, motivation, and intention to engage in falls prevention strategies. This research was a mixed methods study conducted in two phases. Phase 1 comprised three concurrent studies. These aimed to elucidate the issues regarding falls prevention education …

Investigating Community Perspectives On Falls Prevention Information Seeking And Delivery: Older Person Perceptions Regarding Preferences For Falls Prevention Education Using A World Cafe Approach, C Bulsara, L Khong, A Hill, K Hill

Health Sciences Papers and Journal Articles

Falls among older people are a significant global socioeconomic problem, and older adults have low levels of self-perceived risk and a lack of willingness to take up existing falls prevention strategies. We believe that given the challenges of delivering falls prevention information, meaningful engagement of community members would create solutions based on an understanding of what would work best for that community. A World Cafe community forum sought the opinions of 70 community-dwelling older people about their preferences on how they would best receive and seek falls prevention information that could prevent falls within their age group. Participants evaluated the …

Models For Community Based Day Care For Older People: A Narrative Review, C Bulsara, C Etherton-Beer, R Saunders

Health Sciences Papers and Journal Articles

Objectives: Older Australians are choosing to live within the community and there are a number of initiatives to enable this sector of the population to do so for longer. In an effort to ensure that they remain both physically and psychologically engaged, one initiative has been to provide community based day care (CBDC).

Method: A narrative review was undertaken through searching MEDLINE, CINAHL Plus, Scopus and AgeInfo using keywords related to facility related, target group related and purpose/program of CBDC services.

Results: Results indicated that there is a much research investigating different approaches but little consensus regarding the optimal delivery …

Opportunities And Challenges In The Use Of An External Interprofessional Reviewing Body In A Curricular Review Process In A Doctor Of Physical Therapy Curriculum, Jill Fitzgerald, Kelly Hawthorne

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this article is to describe the opportunities and challenges of a curricular review process in an entry-level doctor of physical therapy geriatric curriculum. The curricular review process utilized an external interprofessional reviewing body, in conjunction with an established internal curricular reviewing body, to determine inclusion of Essential Competencies in order to prepare students for best clinical practice in the care of the older adult. Method: The methodology of our curricular review process included both internal and external reviewing bodies but the intent of this article is to highlight how the review process was implemented including an …

Models For Community Based Day Care For Older People: A Narrative Review, Caroline Bulsara, Christopher Etherton-Beer, Rosemary Saunders

Research outputs 2014 to 2021

Objectives:

Older Australians are choosing to live within the community and there are a number of initiatives to enable this sector of the population to do so for longer. In an effort to ensure that they remain both physically and psychologically engaged, one initiative has been to provide community based day care (CBDC).

Method:

A narrative review was undertaken through searching MEDLINE, CINAHL Plus, Scopus and AgeInfo using keywords related to facility related, target group related and purpose/program of CBDC services.

Results:

Results indicated that there is a much research investigating different approaches but little consensus regarding the optimal delivery …

Diabetes And Physical Activity, Jameela Banu

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Diabetes has been on the rise globally. Although many factors contribute to the increasing risk and manifestation of this disease lack and decreased physical activity/ exercise stands out as one of the major factors. Treatment interventions for prediabetic and diabetic patients include diet and lifestyle changes with enhanced physical activity/ exercise. Several types of physical activity are available for these patients but, recommendations have to be made on an individual basis after giving due consideration to the comorbidities and other risks and barriers. Implementation of progressive resistance therapy may be successful in maintaining glucose homeostasis in diabetic patients.

Emerging Technologies To Measure Neighborhood Conditions In Public Health: Implications For Interventions And Next Steps, M. Schootman, E. J. Nelson, K. Werner, E. Shacham, M. Elliott, Kendra Ratnapradipa, M. Lian, A. Mcvay

Journal Articles: Epidemiology

Adverse neighborhood conditions play an important role beyond individual characteristics. There is increasing interest in identifying specific characteristics of the social and built environments adversely affecting health outcomes. Most research has assessed aspects of such exposures via self-reported instruments or census data. Potential threats in the local environment may be subject to short-term changes that can only be measured with more nimble technology. The advent of new technologies may offer new opportunities to obtain geospatial data about neighborhoods that may circumvent the limitations of traditional data sources. This overview describes the utility, validity and reliability of selected emerging technologies to …