Digital Commons Network^™

Resveratrol Supplementation Confers Neuroprotection In Cortical Brain Tissue Of Nonhuman Primates Fed A High-Fat/Sucrose Diet, Michel Bernier, Devin Wahl, Ahmed Ali, Joanne Allard, Shakeela Faulkner, Artur Wnorowski, Mitesh Sanghvi, Ruin Moaddel, Irene Alfaras, Julie A. Mattison, Stefano Tarantini, Zsuzsanna Tucsek, Zoltan Ungvari, Anna Csiszar, Kevin J. Pearson, Rafael De Cabo

Pharmacology and Nutritional Sciences Faculty Publications

Previous studies have shown positive effects of long-term resveratrol (RSV) supplementation in preventing pancreatic beta cell dysfunction, arterial stiffening and metabolic decline induced by high-fat/high-sugar (HFS) diet in nonhuman primates. Here, the analysis was extended to examine whether RSV may reduce dietary stress toxicity in the cerebral cortex of the same cohort of treated animals. Middle-aged male rhesus monkeys were fed for 2 years with HFS alone or combined with RSV, after which whole-genome microarray analysis of cerebral cortex tissue was carried out along with ELISA, immunofluorescence, and biochemical analyses to examine markers of vascular health and inflammation in the …

Ua61/1 External Advisory Board Meeting, Wku School Of Nursing

WKU Administration Documents

Powerpoint presentation for WKU School of Nursing external advisory board meeting.

Faith Community Nurse Care Transitions Intervention Feasibility Project, Jennifer Palagi

Doctor of Nursing Practice Projects

Background: A major national-to-local healthcare quality and safety goal is to reduce hospital readmissions, which are considered preventable patient harm. While the literature shows the impact of using care transitions programs to reduce readmissions, few studies have utilized faith community nurses (FCNs) within care transition programs. An FCN-integrated care transitions program potentially could help fill the gap in community clinical support for chronic illness care. Saint Alphonsus Regional Medical Center (SARMC), a Catholic hospital in Boise, Idaho, sponsors an FCN network within many Southwest Idaho faith communities. This presented a local opportunity to create and test the feasibility of an …

Assessing Functional Impairment In Individuals With Mild Cognitive Impairment, Patricia Da Cunha Belchior, Taranpreet Bains, Jennifer Hargadon, Sofia Tran, Courtney Uphoff, Jade Chiu W. Kwok, Navaldeep Kaur, Isabelle Gelinas

The Open Journal of Occupational Therapy

To date, there is no consensus on how to assess functional impairment in individuals with mild cognitive impairment (MCI), and this lack of consensus is reflected in the clinical practice. Since the criterion used in the literature is very vague, clinicians are still left without much guidance in this area. Thus, the main goal of this study was to examine how functional impairment in individuals with MCI has been assessed in the literature.

An electronic database search strategy was developed in consultation with an experienced librarian. Four databases (CINAHL, PsycINFO, PubMed, and MEDLINE) were searched from 2000 to May 2014 …

Gw Nursing, Spring 2016, George Washington University, School Of Nursing

GW Nursing Magazine

No abstract provided.

Building Expert Consensus On Including Indicators Of Moisture Associated Skin Damage In The National Database Of Nursing Quality Indicators (Ndnqi), Mary Caroleen Arnold Long

Capstone Projects

Pressure ulcer (PU) data are collected by hospitals and reported quarterly as a nursing sensitive quality indicator via the National Database of Nursing Quality Indicators (NDNQI). Incontinence-associated dermatitis (IAD) and gluteal intertriginous dermatitis (ITD), both forms of moisture associated skin damage (MASD), are caused by moisture, not pressure or shear. These two forms of skin damage may be mistaken for PUs and may be reported in error as PUs. If the assessment of the skin damage is incorrect, the reporting is incorrect and the NDNQI database is incorrect. If the NDNQI database is incorrect then practice and policy regarding identification, …

Sensory Closet Program Design For Alzheimer's And Dementia Population, Grace V. Willard

MOT Student Capstones

Background: The prevalence of individuals with Alzheimer's and dementia is growing exponentially in long term care facilities, with restraints and seclusion becoming the method of intervention when behaviors arise (American Occupational Therapy Association, 2015). North Carolina is moving to decrease the amount of physical restraints and psychotropic medication usage in long term care to decrease harm caused to the residents. Project Purpose: This project intends to design a sensory integration closet program for use in a long-term care facility to facilitate a decrease in behavior outbursts and correlating psychotropic medication usage in residents with Alzheimer's disease and dementia. Coinciding training …

2016-2017 Summer Bulletin, University Of Mississippi Medical Center

Bulletins/Catalogs

2016-2017 Summer Bulletin

Neural Activity Reveals Effects Of Aging On Inhibitory Processes During Word Retrieval, Ranjini Mohan

Open Access Dissertations

Word retrieval difficulties are one of the most frustrating problems in older adults. Poorer access to phonological (speech sound) representation of the target word has been postulated as the underlying deficit, supported by findings of improvement in word retrieval after phonological priming. But the great variability in naming performance among older adults may reflect cognitive scaffolding or compensatory neurophysiological processes related to maintenance or decline of naming abilities. In order better understand aging effects in the underlying neurophysiological changes associated with phonological retrieval, the present study examined electrophysiological correlates of phonological priming and word retrieval in adults across the lifespan. …

Gardening/Yard Work And Depressive Symptoms In African Americans, Elisa R. Torres, Carolyn M. Sampselle, David L. Ronis, Harold W. Neighbors, Kimberlee A. Gretebeck

College of Nursing Faculty Research and Publications

Background

The purpose of this study was to examine the frequency of gardening/yard work in relation to depressive symptoms in African-Americans while controlling for biological and social factors.

Methods

A secondary analysis was performed on the National Survey of American Life (n = 2,903) using logistic regression for complex samples. Gardening/Yard work was measured by self-reported frequency. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale.

Results

Biological and social factors, not gardening/yard work, were associated with depressive symptoms.

Conclusions

Biological and social factors may need to be addressed before the association between gardening/yard work and depressive …

Development And Implementation Of A Culturally Tailored, Community-Based Intervention To Raise Awareness Of Brain Health Among African Americans, Mary Ann K. Hall, Ashani Johnson-Turbes, Felicia T. Fuller, Petra Niles, Shileah Cantey-Mcdonald

Journal of Health Disparities Research and Practice

African Americans bear a disproportionate burden of age-related cognitive impairment in the United States compared to Whites or Hispanics. African Americans experience greater prevalence, higher risk, and lower rates of treatment and diagnosis for dementia. In response to these health disparities the Alzheimer’s Association developed and implemented the Healthy Brain Initiative (HBI) demonstration project, the first community-level intervention to help reduce health disparities related to cognitive impairment among African Americans. The HBI promotes awareness of brain health, understanding of the heart-brain connection, and seeks to increase African American baby boomers engagement in health-protective behaviors to promote brain and overall health. …

Learning By Living: Empathy Learned Through An Extended Medical Education Immersion Project, Ianna Hondros-Mccarthy, Philip Barber, Marilyn R. Gugliucci

Geriatric Medicine Faculty Publications

Introduction: Medical student training and experiences in nursing homes are often viewed as negative; however, long-term care services represent a growing aspect of our medical system that receives little attention in medical education. The University of New England College of Osteopathic Medicine Learning by Living Nursing Home Immersion Project accelerates students learning about older adult care and the importance of empathy. Methods: Learning by Living applies qualitative ethnographic/autobiographic research methods to answer the question: “What is it like for me to live the life of an older adult nursing home resident?” Two first year medical students (female, 25 y/o & …

N404 Nursing Care Of The Diverse Veteran Population In Rural And Urban Settings, Ron Ulberg, Kent Blad

Journal of Undergraduate Research

Evaluation of how well the academic objectives of the proposal were met:

The academic objectives of the MEG proposal were met and exceeded. Specifically, students were exposed to local and national venues in which Veterans and their history are prevalent. Examples of this include visits by the students and faculty to Walter Reed National Military Medical Center, VA Medical Center War Related Injury and Illness Study Center, Arlington National Cemetery, US Capitol, Lincoln Memorial, Washington Memorial, WW I Memorial, WW II Memorial, Korean War Memorial, Vietnam War Memorial, Museum of American History, etc. We also met with Senator Mike Lee …

Muscle Strength, Physical Activity, And Functional Limitations In Older Adults With Central Obesity, Cassandra M. Germain, John A. Batsis, Elizabeth Vasquez, Douglas R. Mcquoid

Dartmouth Scholarship

Background: Obesity and muscle weakness are independently associated with increased risk of physical and functional impairment in older adults. It is unknown whether physical activity (PA) and muscle strength combined provide added protection against functional impairment. This study examines the association between muscle strength, PA, and functional outcomes in older adults with central obesity. Methods: Prevalence and odds of physical (PL), ADL, and IADL limitation were calculated for 6,388 community dwelling adults aged ≥ 60 with central obesity. Individuals were stratified by sex-specific hand grip tertiles and PA. Logistic models were adjusted for age, education, comorbidities, and body-mass index and …

Orthostatic Blood Pressure Vitals Signs: Educating Staff To Keep Our Geriatric Population Safe, Hilary A. Boos Bsn, Rn, Erin K. George Bsn, Rn, Kathleen M. Timm Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Incidence And Management Of Polypharmacy, Zillah Mulubisha

Nursing Capstones

No abstract provided.

Age And Employee Green Behaviors: A Meta-Analysis, Brenton M. Wiernik, Stephan Dilchert, Deniz S. Ones

Publications and Research

Recent economic and societal developments have led to an increasing emphasis on organizational environmental performance. At the same time, demographic trends are resulting in increasingly aging labor forces in many industrialized nations. Commonly held stereotypes suggest that older workers are less likely to be environmentally responsible than younger workers. To evaluate the degree to which such age differences are present, we meta-analyzed 132 independent correlations and 336 d-values based on 4676 professional workers from 22 samples in 11 countries. Contrary to popular stereotypes, age showed small positive relationships with pro-environmental behaviors, suggesting that older adults engaged in these workplace …

Stabilization Of Microtubule-Unbound Tau Via Tau Phosphorylation At Ser262/356 By Par-1/Mark Contributes To Augmentation Of Ad-Related Phosphorylation And Aβ42-Induced Tau Toxicity., Kanae Iijima-Ando, Akiko Maruko-Otake, Yosuke Ohtake, Motoki Hayashishita, Michiko Sekiya, Koichi M Iijima

Department of Neuroscience Faculty Papers

Abnormal accumulation of the microtubule-interacting protein tau is associated with neurodegenerative diseases including Alzheimer's disease (AD). β-amyloid (Aβ) lies upstream of abnormal tau behavior, including detachment from microtubules, phosphorylation at several disease-specific sites, and self-aggregation into toxic tau species in AD brains. To prevent the cascade of events leading to neurodegeneration in AD, it is essential to elucidate the mechanisms underlying the initial events of tau mismetabolism. Currently, however, these mechanisms remain unclear. In this study, using transgenic Drosophila co-expressing human tau and Aβ, we found that tau phosphorylation at AD-related Ser262/356 stabilized microtubule-unbound tau in the early phase of …

Fear Conditioning And Extinction In Youth With Obsessive-Compulsive Disorder, Joseph F. Mcguire, Scott P. Orr, Monica S. Wu, Adam B. Lewin, Brent J. Small, Vicky Phares, Tanya K. Murphy, Sabine Wilhelm, Daniel S. Pine, Daniel Geller, Eric A. Storch

Psychology Faculty Publications

BACKGROUND: Fear acquisition and extinction are central constructs in the cognitive-behavioral model of obsessive-compulsive disorder (OCD), which underlies exposure-based cognitive-behavioral therapy (CBT). Youth with OCD may have impairments in fear acquisition and extinction that carry treatment implications. We examined these processes using a differential conditioning procedure.

METHODS: Forty-one youth (19 OCD, 22 community comparisons) completed a battery of clinical interviews, rating scales, and a differential conditioning task that included habituation, acquisition, and extinction phases. Skin conductance response (SCR) served as the primary dependent measure.

RESULTS: During habituation, no difference between groups was observed. During acquisition, differential fear conditioning was observed …

Trait Hope And Preparation For Future Care Needs Among Older Adult Primary Care Patients, Jodi L. Southerland, Deborah L. Slawson, Robert Pack, Silvia Sörensen, Jeffrey M. Lyness, Jameson K. Hirsch

ETSU Faculty Works

We examined associations between trait hope and preparation for future care needs (PFCN) among 66 older adult primary care patients in western New York. Participants completed a questionnaire assessing PFCN (awareness, information gathering, decision-making, concrete planning, and avoidance), and the Adult Trait Hope Scale. In multivariate regressions, lower hope, particularly less agency, was associated with more awareness of needing care, whereas higher hopefulness, particularly pathways thinking, was associated with increased decision-making and concrete planning. Greater hopefulness appears to be linked to goal-directed planning behaviors, although those with lower hope may actually be more aware of the need for planning. Evidence-based …

Techniques And Approaches To Genetic Analyses In Nephrological Disorders., Laurel K. Willig

Manuscripts, Articles, Book Chapters and Other Papers

Inherited renal disease is a leading cause of morbidity and mortality in pediatric nephrology. High throughput advancements in genomics have led to greater understanding of the biologic underpinnings of these diseases. However, the underlying genetic changes explain only part of the molecular biology that contributes to disease manifestation and progression. Other omics technologies will provide a more complete picture of these cellular processes. This review discusses these omics technologies in the context of pediatric renal disease.

Ms171: Interview With Marianne Marcus, Marianne Marcus Edd, Rn, Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral history with Marianne Marcus, Professor Emerita at the University of Texas at Houston School of Nursing. Before she retired and assumed the title of Professor Emerita in 2104, Dr. Marcus chaired the UT Nursing School’s Department of Nursing Systems, directed its Master’s of Nursing Education degree track and directed its Center for Substance Abuse Prevention, Education and Research. While at UT, she was elected to its Academy of Health Science Education and named as a Fellow of the American Academy of Nursing. She was appointed the John P. McGovern Distinguished Professor of Addiction Nursing at UT Health Science …

Ms171: Interview With Margaret Caddy, Margaret Caddy, Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral History interview with Margaret Caddy discussing her nursing and administrative career in Houston and the Texas Medical Center. Caddy worked in hospice care from 1983-2009. Part of that time, She served as the Executive Director for Houston Hospice. See more at Texas Medical Center-Women's History Project and its finding aid.

Psychometric Evaluation Of The Physical Activity Enjoyment Scale In Adults With Functional Limitations, Carolyn J. Murrock, Abir K. Bekhet, Jaclene A. Zauszniewski

College of Nursing Faculty Research and Publications

Enjoyment is an important construct for understanding physical activity participation, and it has not been examined in adults with functional limitations. This secondary analysis reported the reliability and validity of the Physical Activity Enjoyment Scale (PACES) in a convenience sample of 40 adults with functional limitations. The participants completed the PACES, Center for Epidemiological Studies Depression Scale (CES-D), and the Late Life Function and Disability Instrument (LLFDI) prior to beginning a 12-week feasibility dance intervention study. Results indicated reliability as Cronbach's alpha was .95 and mean inter-item correlation was .52. To further support reliability, homogeneity of the instrument was evaluated …

The Effect Of A Resourcefulness Training Intervention On Relocation Adjustment And Adaptive Functioning Among Older Adults In Retirement Communities, Abir K. Bekhet, Jaclene A. Zauszniewski

College of Nursing Faculty Research and Publications

The population of older adults is increasing rapidly and is expected to reach 83.7 million by the year 2050. Previous research demonstrates that greater resourcefulness is associated with better quality of life and life satisfaction. The purpose of this pilot study was to evaluate the effects of a resourcefulness training intervention on positive cognitions, resourcefulness, relocation adjustment, and adaptive functioning among older adults who have relocated to retirement communities. Resourcefulness theory provided the theoretical framework for this study. Forty older adults who relocated to three retirement communities in Milwaukee, WI were randomly assigned to either a diversional activity group or …

Significance Of Tumor Marker Ca15-3 In Metastatic Breast Cancer, Hoor Fatima, Amir Maqbool, Marium Siddiqui, Ghulam H, Habiba Sohail, Omema Saleem, Afarina Ahmed

Department of Medicine

Secondary spread of cancer to bones is commonest and frequent phenomenon and enhances the need of special care for sufferers. Bone metastases mostly are the first complication of different variety of cancers which increase the need of care and expensive facilities. Blood dissemination is another common route, might be due to the venous drainage from visceral organs directly into the axial bones. CA 15-3 is a mucinous tumor markers derived from MUC1 gene, provides better guide line about the treatment, recurrence and prognosis.

Aim: Aim of the study was to signify the role of tumor marker CA15-3 in metastatic breast …

Implementing Faith Community Nursing Interventions To Promote Healthy Behaviors In Adults, Donna M. Callaghan

International Journal of Faith Community Nursing

Purpose: To report the implementation of faith community nursing interventions to promote healthy behaviors in adults. Callaghan (2015) reported the development of this intervention, which was based on previous studies that support the importance of spiritual growth on the initiative and responsibility for self-care across the life span (Callaghan, 2003, 2005, 2006). The intervention also included strategies to increase self-efficacy of healthy behaviors. The results of three separate implementations of the health promotion intervention are presented in this report.

Procedures: Three health promotion programs were implemented over a five year period (2010 – 2015). These programs were offered for the …

Does Yoga Practice Improve Balance In Older Adults?, Joanna Alfieri, Spt, Andrea Barberio, Spt, Ryt-500, Rebecca Mccammitt, Spt, Kevin Reeder, Spt, Susan Duff, Pt, Edd, Cht, Ryt-200

Department of Physical Therapy Capstone Posters

Purpose and Hypothesis:

The purpose of this systematic review was to determine the effects of a regular yoga program on balance in older adults. We hypothesized that a regular yoga program would improve balance and consequently reduce fall risk in the older adult population.

Alzheimer's Biomarkers Are Correlated With Brain Connectivity In Older Adults Differentially During Resting And Task States, Yang Jiang, Haiqing Huang, Erin Abner, Lucas S. Broster, Gregory A. Jicha, Frederick A. Schmitt, Richard Kryscio, Anders H. Andersen, David Powell, Linda J. Van Eldik, Brian T. Gold, Peter T. Nelson, Charles D. Smith, Mingzhou Ding

Behavioral Science Faculty Publications

β-amyloid (Aβ) plaques and tau-related neurodegeneration are pathologic hallmarks of Alzheimer’s disease (AD). The utility of AD biomarkers, including those measured in cerebrospinal fluid (CSF), in predicting future AD risk and cognitive decline is still being refined. Here, we explored potential relationships between functional connectivity (FC) patterns within the default-mode network (DMN), age, CSF biomarkers (Aβ₄₂ and pTau₁₈₁), and cognitive status in older adults. Multiple measures of FC were explored, including a novel time series-based measure [total interdependence (TI)]. In our sample of 27 cognitively normal older adults, no significant associations were found between levels of Aβ …

2015-2016 Spring Bulletin, University Of Mississippi Medical Center

Bulletins/Catalogs

2015-2016 Spring Bulletin