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The Impact Of Computer Training On Confidence And Occupational Participation In Community-Dwelling Older Adults, Alicia Jones, Joseph A. Scazzero, Rosanne Dizazzo-Miller Jul 2026

The Impact Of Computer Training On Confidence And Occupational Participation In Community-Dwelling Older Adults, Alicia Jones, Joseph A. Scazzero, Rosanne Dizazzo-Miller

The Open Journal of Occupational Therapy

Background: It is fundamental to understand why older adults choose and use technology to fully understand how to meet the needs of an aging population in a technologically advanced society. This research aimed to design and implement a holistic technology training program for older adults that explores using a laptop beyond basic internet use.

Method: A pre-post mixed-method survey study took place at a local senior center. A classroom-style program was designed to deliver information and instruction using a digital device. An 11-item survey on attitudes toward technology using a 7-point Likert scale with qualitative responses was used to collect …


The Content Validity Of The Functional Cognition Index In Instrumental Activities Of Daily Living (Fci-Iadl) As A Screening Tool For Mild Cognitive Impairment (Mci) In Older Adults In Singapore, Namrata P. Sadarangani, Phyllis Simon Jul 2026

The Content Validity Of The Functional Cognition Index In Instrumental Activities Of Daily Living (Fci-Iadl) As A Screening Tool For Mild Cognitive Impairment (Mci) In Older Adults In Singapore, Namrata P. Sadarangani, Phyllis Simon

The Open Journal of Occupational Therapy

Background: Mild Cognitive Impairment (MCI) is a syndrome that is considered a transition phase between healthy cognitive aging and dementia. The person may have subjective memory complaints, substantiated by family or caregiver and/or impaired executive function, that lead to difficulties performing complex Instrumental Activities of Daily Living (IADLs). Our objective was to develop a tool to assess functional cognition in IADLs as a screen for MCI in older adults.

Method: A Qualtrics survey questionnaire was rated by 15 content experts on the relevance of the 22 test item questions to the cognitive domains being measured using a 4-point …


Enhancing Well-Being: Implementing Weekly Social Interventions For Older Adults In Independent Living, Rosa Huang Jul 2026

Enhancing Well-Being: Implementing Weekly Social Interventions For Older Adults In Independent Living, Rosa Huang

Dissertations

Loneliness and social isolation significantly impact the physical and mental well-being of older adults. This quality improvement project implemented an eight-week social intervention designed to reduce loneliness and enhance well-being through weekly sessions incorporating mindfulness exercises, gratitude journaling, and structured socialization activities. The intervention was delivered by nursing students to a sample of residents in a Midwestern independent living community. While most standardized measures of loneliness and mood did not show statistically significant changes, the project resulted in a statistically significant increase in social network engagement as measured by the Lubben Social Network Scale-6 (LSNS-6). The findings suggest that group-based …


Reducing Emergency Department Boarding Using Pull-Based Throughput Intervention: Quality Improvement Project, Eunice Dundu Jul 2026

Reducing Emergency Department Boarding Using Pull-Based Throughput Intervention: Quality Improvement Project, Eunice Dundu

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Emergency department (ED) boarding increases overcrowding and delays care. A 200-bed acute care hospital in the southeastern United States has a median time from inpatient bed readiness to ED departure that exceeds its hospital benchmarks, resulting in prolonged boarding and delays. Hospital data showed a median bed-ready-to-departure time of 76 minutes, exceeding the target of less than 45 minutes. Workflow analysis identified delays in transport activation, communication, and accountability as major contributors to inefficiency.

Aim of the Project: ED throughput quality improvement project aimed to reduce the median time from when an inpatient bed is marked ready to …


Improving Medication Reconciliation Compliance In Home Health Admissions, Paula A. Petrie-Rivas Jul 2026

Improving Medication Reconciliation Compliance In Home Health Admissions, Paula A. Petrie-Rivas

All Doctor of Nursing Practice (DNP) Scholarly Projects

Background: Clinician compliance with medication reconciliation at a home health agency was below regulatory expectations, with agency performance significantly lower than state and national averages. Workflow inefficiencies, inconsistent clinician practices, and limited training contributed to noncompliance, increasing the risk of medication discrepancies, preventable rehospitalizations, and Medicare reimbursement penalties.

Aim: This quality improvement project implemented a standardized medication reconciliation workflow using the Agency for Healthcare Research and Quality’s MATCH toolkit to improve clinician compliance during admission to home health.

Evidence: Literature supports structured medication reconciliation as an effective strategy to improve safety during transitions of care. The MATCH toolkit provides a …


Bridging Gaps In Spanish-Speaking Individuals In Rural Areas About Parkinson’S Disease, Fabiola Barajas Velasco Jul 2026

Bridging Gaps In Spanish-Speaking Individuals In Rural Areas About Parkinson’S Disease, Fabiola Barajas Velasco

Occupational Therapy Student Capstones

Provide education and bring awareness of Parkinson’s disease in rural areas through educational trainings and community outreach, specifically those close in contact with farmworkers or farmworkers themselves.


Kickin' It Old School: Connecting The Ages, Elyssia Lambert Jul 2026

Kickin' It Old School: Connecting The Ages, Elyssia Lambert

Occupational Therapy Student Capstones

Problem Statement

Lack of social participation is associated with negative impacts on QoL in individuals with dementia

Lack of awareness and knowledge of OT as a career option


Discordance Between Self-Report And Performance-Based Measures Among At-Risk Older Adults: A Secondary Data Analysis, Chiung-Ju Liu, Wen-Pin Chang, Inga Wang Jul 2026

Discordance Between Self-Report And Performance-Based Measures Among At-Risk Older Adults: A Secondary Data Analysis, Chiung-Ju Liu, Wen-Pin Chang, Inga Wang

Occupational Therapy Faculty Publications

Importance: Subtle, age-related declines in occupational performance among at-risk older adults may go undetected when assessed solely with self-report measures, potentially leading to missed intervention opportunities. Understanding discrepancies between self-reported and performance-based occupational performance outcomes can inform assessment selection and interpretation.

Objective: To examine the discrepancies between the two types of measure among community-dwelling older adults at risk for losing independence.

Design: Cross-sectional study using secondary data analysis.

Participants: Seventy-one community-dwelling older adults (M age = 74 yr, SD = 9) who showed muscle weakness and reported difficulty with activities of daily living.

Outcomes and measures: Canadian Occupational Performance Measure …


Medadl: High-Throughput Information Extraction Of Functional Status From Electronic Health Records To Advance Frailty Assessment In Older Adults, Sunyang Fu, Zhiyi Yue, Jennyly T Nguyen, Huipeng Liu, Jaerong Ahn, Vanessa Ramirez, Jude Des Bordes, Hongfang Liu, Min Ji Kwak, Nahid J Rianon Jul 2026

Medadl: High-Throughput Information Extraction Of Functional Status From Electronic Health Records To Advance Frailty Assessment In Older Adults, Sunyang Fu, Zhiyi Yue, Jennyly T Nguyen, Huipeng Liu, Jaerong Ahn, Vanessa Ramirez, Jude Des Bordes, Hongfang Liu, Min Ji Kwak, Nahid J Rianon

Faculty, Staff and Student Publications

Background: Functional status is essential for assessing frailty and planning care in older adults but is often under-documented in the structured fields of electronic health records. Manual chart review can capture functional status information but is labor-intensive and time-consuming. In this study, we developed and validated a scalable natural language processing (NLP) model to extract functional status information from unstructured electronic health record (EHR) notes.

Methods: This retrospective cohort study included 110 older adults seen at a geriatric osteoporosis clinic. A large language model-augmented symbolic NLP pipeline (MedADL) was developed to extract activities of daily living (ADL) and instrumental activities …


A Phase-Ii Randomized Controlled Pilot Study Of Nicotinamide Riboside Supplementation In Older Adults With Amnestic Mild Cognitive Impairment, Christopher Martens, Kevin Decker, Theodore Deconne, Faria Sanjana, Fiona Horvat, Nicholas Rizzi, Catherine Awad, Elizabeth Habash, Joshua Hobson, Mary Kramer, Michael Armstrong, Nichole Reisdorph, Ryan Pohlig, Alyssa Lanzi, Curtis Johnson, Matthew Cohen, James Ellison Jul 2026

A Phase-Ii Randomized Controlled Pilot Study Of Nicotinamide Riboside Supplementation In Older Adults With Amnestic Mild Cognitive Impairment, Christopher Martens, Kevin Decker, Theodore Deconne, Faria Sanjana, Fiona Horvat, Nicholas Rizzi, Catherine Awad, Elizabeth Habash, Joshua Hobson, Mary Kramer, Michael Armstrong, Nichole Reisdorph, Ryan Pohlig, Alyssa Lanzi, Curtis Johnson, Matthew Cohen, James Ellison

Department of Psychiatry and Human Behavior Faculty Papers

INTRODUCTION: Declining nicotinamide adenine dinucleotide (NAD+) may elevate risk of Alzheimer's disease.

METHODS: We conducted a 12-week double-blind, randomized, placebo-controlled pilot study to evaluate the safety, tolerability, and preliminary efficacy of the NAD+ precursor, nicotinamide riboside (NR), for enhancing cognitive function and cerebral blood flow (CBF) in adults with amnestic mild cognitive impairment (aMCI).

RESULTS: 42 participants completed the study (NR = 22, placebo = 20). Adherence was similar between groups with no serious adverse effects. Blood NAD+ increased twofold in the NR group. There were no improvements in cognitive function (primary outcome), total CBF, or blood pressure (secondary outcomes). …


School Of Nursing Newsletter Summer 2026, Southern Adventist University Jul 2026

School Of Nursing Newsletter Summer 2026, Southern Adventist University

Southern Nursing - School of Nursing Newsletter

The Summer 2026 issue of the newsletter features information on the Hamilton County Homeland Security emergency preparedness event held in April, an update on the Nursing Simulation Center, the spring RHO IOTA induction ceremony, and mission trip experiences.


Challenge-Based Ex Vivo Immune Profiling Reveals Stimulus-Dependent Peripheral Immune Reprogramming In Alzheimer's Disease, C. A. Naranjo-Galvis, Jovanny Zabaleta, Ney Alliey Rodriguez, Luisa Matilde Salamanca-Duque Jul 2026

Challenge-Based Ex Vivo Immune Profiling Reveals Stimulus-Dependent Peripheral Immune Reprogramming In Alzheimer's Disease, C. A. Naranjo-Galvis, Jovanny Zabaleta, Ney Alliey Rodriguez, Luisa Matilde Salamanca-Duque

School of Medicine Publications

Altered immune function is increasingly recognized as a contributor to Alzheimer's disease (AD); however, it remains unclear whether peripheral immune alterations reflect constitutive inflammation or stimulus-dependent changes in immune responsiveness. Addressing this distinction is critical for understanding immune dysregulation in neurodegenerative diseases. In this study, we applied a challenge-based ex vivo immune profiling approach to characterize functional immune responsiveness in patients with AD and in cognitively healthy older adults. Peripheral blood mononuclear cells were exposed to defined innate, antigenic, and mitogenic stimuli, and cytokine and β-amyloid (Aβ) responses were quantified in culture supernatants. Diagnosis-by-stimulus interaction effects were assessed using generalized …


The Association Between Osteoporosis In Females Following Menopause And Vitamin D Deficiency, Hadel Kareem Al-Rubaiawi, Noor Adel Hussein, Dunia Abdul Jabbar Star, Amer Hasan Abdullah, Salma Abdul-Ridha Abbas, Hawazin Aziz Hamim Jun 2026

The Association Between Osteoporosis In Females Following Menopause And Vitamin D Deficiency, Hadel Kareem Al-Rubaiawi, Noor Adel Hussein, Dunia Abdul Jabbar Star, Amer Hasan Abdullah, Salma Abdul-Ridha Abbas, Hawazin Aziz Hamim

Al-Esraa University College Journal for Medical Sciences

The intricate relationship among osteoporosis, vitamin D deficiency, and hormonal changes. Growth hormone, cortisol, parathyroid hormone, estrogen, testosterone, thyroid hormones, and thyroid hormones are a few of the hormones that affect bone turnover and density. Alterations in their concentrations, whether brought on by healthy aging or illnesses, can interfere with bone remodelling and increase the risk of osteoporosis. Moreover, inadequate levels of vitamin D increase the risk by decreasing the absorption of calcium and the mineralization of bone. Estrogen and vitamin D deficits increase bone loss, especially in postmenopausal women. Proactive treatment techniques, including hormone replacement therapy, vitamin D supplements, …


The Effect Of The Lee Silverman Voice Treatment (Lsvt) Big Method Based On Occupation On Older Adult Functional Mobility Balance, Muhammad Luthfi, Kharisma Nur Idalasari Jun 2026

The Effect Of The Lee Silverman Voice Treatment (Lsvt) Big Method Based On Occupation On Older Adult Functional Mobility Balance, Muhammad Luthfi, Kharisma Nur Idalasari

Jurnal Fisioterapi Terapan Indonesia

Balance impairment is one of the major problems commonly experienced by older adults as a result of degenerative processes, leading to an increased risk of falls. Falls may cause fear of recurrent falling, reduced physical activity, loss of physical capability, and may eventually result in disability and psychological consequences such as depression. Structured, occupation-based physical activity has been shown to provide various benefits for older adults, including improving physical function, slowing functional decline associated with degenerative processes, reducing fall risk, and enhancing postural control. This study aimed to analyze the effect of the occupation-based Lee Silverman Voice Treatment (LSVT) BIG …


Plasma Gdf15 Affects Long-Term Dementia Risk And Alters Neuroimmune Signaling, Cassandra O Blew, Michael R Duggan, Dimitrios Tsitsipatis, Gabriela T Gomez, Zulema Rodriguez-Hernandez, Luke C Pilling, Jingsha Chen, Eva Jacobsen, Heather E Dark, Yifei Lu, Shannon M Drouin, Cassandra M Joynes, Minhao Yao, Murat Bilgel, Abhay Moghekar, Qu Tian, Julián Candia, Mary Kaileh, Aditi Gupta, Krystyna Mazan-Mamczarz, Myriam Gorospe, Alexey Lyashkov, Yevgeniya Lukyanenko, Mika Kivimaki, Philipp Frank, Lori L Jennings, Valborg Gudmundsdottir, Vilmundur Gudnason, Lenore J Launer, Naoto Kaneko, Shintaro Kato, Makio Furuichi, Masaki Shibayama, Masahisa Katsuno, Keita Hiraga, Yukiko Nishita, Rei Otsuka, James R Pike, Mary R Rooney, Pascal Schlosser, Yuhan Cui, Guray Erus, Christos Davatzikos, Rebecca F Gottesman, Iwao Waga, Priya Palta, Christie Ballantyne, Michael Griswold, Zhonghua Liu, Luigi Ferrucci, Allison B Herman, Keenan A Walker Jun 2026

Plasma Gdf15 Affects Long-Term Dementia Risk And Alters Neuroimmune Signaling, Cassandra O Blew, Michael R Duggan, Dimitrios Tsitsipatis, Gabriela T Gomez, Zulema Rodriguez-Hernandez, Luke C Pilling, Jingsha Chen, Eva Jacobsen, Heather E Dark, Yifei Lu, Shannon M Drouin, Cassandra M Joynes, Minhao Yao, Murat Bilgel, Abhay Moghekar, Qu Tian, Julián Candia, Mary Kaileh, Aditi Gupta, Krystyna Mazan-Mamczarz, Myriam Gorospe, Alexey Lyashkov, Yevgeniya Lukyanenko, Mika Kivimaki, Philipp Frank, Lori L Jennings, Valborg Gudmundsdottir, Vilmundur Gudnason, Lenore J Launer, Naoto Kaneko, Shintaro Kato, Makio Furuichi, Masaki Shibayama, Masahisa Katsuno, Keita Hiraga, Yukiko Nishita, Rei Otsuka, James R Pike, Mary R Rooney, Pascal Schlosser, Yuhan Cui, Guray Erus, Christos Davatzikos, Rebecca F Gottesman, Iwao Waga, Priya Palta, Christie Ballantyne, Michael Griswold, Zhonghua Liu, Luigi Ferrucci, Allison B Herman, Keenan A Walker

Faculty, Staff and Students Publications

Growth/differentiation factor-15 (GDF15) is a secreted cytokine strongly associated with dementia risk. However, the extent to which GDF15 represents a biomarker and driver of dementia risk remains unclear. Across multiple cohorts, we demonstrated that plasma GDF15 is associated with greater dementia risk over 15- to 25-year follow-up periods when measured in midlife, with stronger associations observed for vascular, compared to Alzheimer's disease (AD), dementia. Two-sample Mendelian randomization supported plasma GDF15's mechanistic role in AD and related dementias, while cohort studies linked it to cerebral small vessel disease, neurodegeneration, phosphorylated tau, and a cerebrospinal fluid proteomic signature indicative of neuroimmune activation. …


Implementation Of Standardized Mental Health Screening And Referral Protocols For Depression In Patients Aged 65 And Older In Primary Care Settings, Elizabeth Nyambura Irungu Jun 2026

Implementation Of Standardized Mental Health Screening And Referral Protocols For Depression In Patients Aged 65 And Older In Primary Care Settings, Elizabeth Nyambura Irungu

Walden Dissertations and Doctoral Studies

No abstract provided.


The Effect Of Structured Prebriefing On Pre-Simulation Anxiety In Baccalaureate Nursing Students Participating In High-Fidelity Simulation: A Quantitative Quasi-Experimental Nonequivalent Pretest-Posttest Control Group Study, Laura D. Wade Jun 2026

The Effect Of Structured Prebriefing On Pre-Simulation Anxiety In Baccalaureate Nursing Students Participating In High-Fidelity Simulation: A Quantitative Quasi-Experimental Nonequivalent Pretest-Posttest Control Group Study, Laura D. Wade

Doctoral Dissertations and Projects

The purpose of this quantitative quasi-experimental nonequivalent pretest-posttest control group study was to examine the effect of structured prebriefing on pre-simulation state anxiety among baccalaureate nursing students participating in high-fidelity simulation (HFS) at a private faith-based university in the South-Central United States (U.S.). Simulation is widely used in nursing education; however, nursing students frequently experience elevated anxiety prior to simulation that may negatively influence learning and performance. Despite recognition of prebriefing as best practice in simulation-based education, limited quantitative research has examined the effect of structured prebriefing on pre-simulation anxiety. A convenience sample of 73 baccalaureate nursing students enrolled in …


Comprehensive Geriatric Assessment Identifies Multidimensional Vulnerabilities In Older Adults With Heart Failure, Ci̇han Kiliç, Rengi̇n Demi̇r, Özlem Yilmaz Aykent, Zerri̇n Yi̇ği̇t, Pinar Küçükdağli, Banu Özulu Türkmen, Güli̇stan Bahat, Mehmet Aki̇f Karan Jun 2026

Comprehensive Geriatric Assessment Identifies Multidimensional Vulnerabilities In Older Adults With Heart Failure, Ci̇han Kiliç, Rengi̇n Demi̇r, Özlem Yilmaz Aykent, Zerri̇n Yi̇ği̇t, Pinar Küçükdağli, Banu Özulu Türkmen, Güli̇stan Bahat, Mehmet Aki̇f Karan

Turkish Journal of Medical Sciences

Background/aim: Heart failure (HF) in older adults is frequently accompanied by geriatric syndromes that remain unrecognized in conventional cardiac evaluations. The vulnerabilities of older adults with and without HF in terms of muscle strength, physical performance, functional capacity, frailty, nutritional status, cognition, mood, anxiety, polypharmacy, and comorbidity were investigated using comprehensive geriatric assessment (CGA).

Materials and methods: A cross-sectional study was conducted in two academic outpatient clinics, enrolling 420 adults aged ≥60 years, including 92 (21.9%) with HF. Data included sociodemographic characteristics, anthropometric measurements, and CGA parameters: handgrip strength, the Five-Times Sit-to-Stand Test (FTSST), the Short Physical Performance Battery (SPPB), …


Equine-Assisted Therapy For Dementia: A Pilot Rct On Standardizing Sessions To Improve Cognition, Mood, And Quality Of Life, Madeline Alford, Maria Dos Prazeres Da Silva Gonçalves Dr., Maria Manuela Da Silva Leite Dr. Jun 2026

Equine-Assisted Therapy For Dementia: A Pilot Rct On Standardizing Sessions To Improve Cognition, Mood, And Quality Of Life, Madeline Alford, Maria Dos Prazeres Da Silva Gonçalves Dr., Maria Manuela Da Silva Leite Dr.

People and Animals: The International Journal of Research and Practice

Objectives: This study aimed to evaluate the effects of incorporating equine-assisted therapy (EAT) into memory workshops for older adults with mild to moderate dementia. EAT is hypothesized to enhance cognitive function, promote physical activity, and improve mood through multisensory experiences. To ensure consistency and replicability, a standardized 8-session cognitive stimulation therapy (CST) protocol was developed, structuring interventions across cognitive, emotional, and motor domains.

Methods: A 3-arm, parallel-group, randomized controlled trial (ClinicalTrials .gov: NCT06662578) was conducted with 36 older adults diagnosed with mild to moderate dementia. Participants were randomly assigned to one of three groups: equine-assisted therapy workshop (EATW), traditional …


Disability Rates Among South Asian Immigrants In The U.S. Vary By Country Of Origin, Sobia Mushtaq, Marc A. Garcia Jun 2026

Disability Rates Among South Asian Immigrants In The U.S. Vary By Country Of Origin, Sobia Mushtaq, Marc A. Garcia

Population Health Research Brief Series

South Asian immigrants are often grouped together in U.S. health data, masking significant differences in health outcomes across subgroups. This brief uses data from the American Community Survey (ACS) 5-Year Public Use Microdata Sample (N = 6,643,738; 2020–2024) to describe disability rates among foreign-born adults from India, Pakistan, and Bangladesh residing in the U.S. The authors find that while South Asian immigrants as a group have lower disability rates than U.S.-born adults, this average is driven largely by Indian immigrants, who make up about 79% of South Asians in the U.S. Among adults aged 65 and older, Bangladeshi immigrants have …


How Do Us States Define Person-Centered And Family-Involved Care In Assisted Living Regulations, Paula Carder, Lindsey Smith, Jennifer N. Bunker, Cassandra L. Hua, Erh-Chi Hsu, Isabelle Boun, Olivia M. Ainsworth, Kali S. Thomas, Eric Jutkowitz Jun 2026

How Do Us States Define Person-Centered And Family-Involved Care In Assisted Living Regulations, Paula Carder, Lindsey Smith, Jennifer N. Bunker, Cassandra L. Hua, Erh-Chi Hsu, Isabelle Boun, Olivia M. Ainsworth, Kali S. Thomas, Eric Jutkowitz

Institute on Aging Publications

Introduction: A large share of assisted living (AL) residents have a diagnosis of dementia or cognitive impairment, and these individuals can benefit from person-centered care and family-involved care. This study examines whether and how states’ AL licenses address these topics.MethodsThis research analyzed a national database of 249 unique licensing requirements that govern 35,602 ALs in all states and associated regulations, including those that govern memory care (MC) services. We reviewed each regulation for the presence of person-centered or family involved care and then used content analysis of license requirements with at least one relevant policy to identify key categories and …


Development And Preliminary Validation Of Orca-Pd, An Online Rapid Cognitive Assessment For Parkinson Disease: Mixed Methods Study, Avigail Lithwick Algon, Sarah Brisman, Chi-Ying R Lin, William Saban Jun 2026

Development And Preliminary Validation Of Orca-Pd, An Online Rapid Cognitive Assessment For Parkinson Disease: Mixed Methods Study, Avigail Lithwick Algon, Sarah Brisman, Chi-Ying R Lin, William Saban

Faculty, Staff and Students Publications

Background: Traditional in-person neuropsychological tests for Parkinson disease (PD) lack accessibility, scalability, and PD specificity. Mobility impairments hinder access to in-person assessments, and long waiting times for expert evaluation limit scalability. Common tools for cognitive screening, such as the Montreal Cognitive Assessment, are generic and not specific to PD.

Objective: The goal of this study was to address these challenges by leveraging the internet. This study aimed to develop a sensitive tool to detect cognitive impairments in early- to mid-stage PD in an accessible and scalable manner.

Methods: We developed the Online Rapid Cognitive Assessment for Parkinson's Disease (ORCA-PD), a …


Open Versus Locked Unit To Safely Foster Dementia Wandering, Marie Cummings Rn Jun 2026

Open Versus Locked Unit To Safely Foster Dementia Wandering, Marie Cummings Rn

Nurse Residency

How would the inclusion of a locked medical-surgical unit for patients with dementia who exhibit wandering behavior prevent elopement, reduce involuntary holds and restraint use, and high rates behavioral codes that are experienced on open units such as Mid Coast Hospital’s medical-surgical unit?


Garlic-Derived Metabolite Activates Lkb1, Promotes Adipose Enampt Secretion, And Improves Age-Related Muscle Function Via Hypothalamic Signaling, Jun-Ichiro Suzuki, Kiyoshi Yoshioka, Masahiro Kurita, Takumi Sugimoto, Takahiro Eguchi, Naoki Ito, Aoi Kodama, Yasutomi Kamei, Masahiro Ohtani, Toshiaki Matsutomo, Shin-Ichiro Imai Jun 2026

Garlic-Derived Metabolite Activates Lkb1, Promotes Adipose Enampt Secretion, And Improves Age-Related Muscle Function Via Hypothalamic Signaling, Jun-Ichiro Suzuki, Kiyoshi Yoshioka, Masahiro Kurita, Takumi Sugimoto, Takahiro Eguchi, Naoki Ito, Aoi Kodama, Yasutomi Kamei, Masahiro Ohtani, Toshiaki Matsutomo, Shin-Ichiro Imai

2020-Current year OA Pubs

Garlic (Allium sativum L.) and its aged extract contain many bioactive compounds that can bring health benefits to humans. Among them, S-1-propenyl-L-cysteine (S1PC) has recently drawn significant attention in the field of nutriceutical research. However, the mechanism of its molecular action has remained poorly understood. Here, we show that S1PC significantly activates liver kinase B1 (LKB1) through enhancing its tertiary complex formation with STRAD and MO25, leading to stimulating the phosphorylation of a mammalian NAD


The Crossroads Between Osteosarcopenia And Intrinsic Capacity—A Narrative Review, Nailton J. Neto, Guy Hajj-Boutros, Wayne Lok Ok Choo, Miguel G. Borda, Konstantinos Prokopidis, Hassan Rammal, Daniel Rivas, Hussein Samhat, Ivan Baltasar-Fernandez, Mahdi Imani, Cristiano Dos Santos Gomes, Oscar Rosas Carrasco, Marc Sim, Julie A. Pasco, Julia Chabot, Ana M. Ayala-Copete, Francisco J. García-García, Claire Godard-Sebillotte, Raman Agnihotram, Lana J. Williams, Anna Andrianova, Robinson Ramirez-Vélez, Emma Connolly, Harmehr Sekhon, Hidenori Arai, Liang-Kung Chen, Andréa Faust, Howard Bergman, Alexandra Papaioannou, Pierrette Gaudreau, Tiago Alexandre, Leocadio Rodriguez-Mañas, Ricardo Oliveira Guerra, Gustavo Duque Jun 2026

The Crossroads Between Osteosarcopenia And Intrinsic Capacity—A Narrative Review, Nailton J. Neto, Guy Hajj-Boutros, Wayne Lok Ok Choo, Miguel G. Borda, Konstantinos Prokopidis, Hassan Rammal, Daniel Rivas, Hussein Samhat, Ivan Baltasar-Fernandez, Mahdi Imani, Cristiano Dos Santos Gomes, Oscar Rosas Carrasco, Marc Sim, Julie A. Pasco, Julia Chabot, Ana M. Ayala-Copete, Francisco J. García-García, Claire Godard-Sebillotte, Raman Agnihotram, Lana J. Williams, Anna Andrianova, Robinson Ramirez-Vélez, Emma Connolly, Harmehr Sekhon, Hidenori Arai, Liang-Kung Chen, Andréa Faust, Howard Bergman, Alexandra Papaioannou, Pierrette Gaudreau, Tiago Alexandre, Leocadio Rodriguez-Mañas, Ricardo Oliveira Guerra, Gustavo Duque

Research outputs 2022 to 2026

Intrinsic capacity (IC) is defined as the composite of physical and mental abilities an individual possesses, encompassing 5 domains: cognition, psychological health, sensory function, vitality, and locomotion. This construct is central to the World Health Organization’s framework for assessing functional ability in older adults. Growing evidence highlights the critical role of the musculoskeletal system in maintaining these domains, while conditions such as sarcopenia, osteoporosis, and their coexistence as osteosarcopenia (OS) are increasingly associated with IC decline. This narrative review compiles current evidence on the modulatory role of muscles and bones in IC and the impacts of sarcopenia, osteoporosis, and OS. …


The Interplay Between Osteosarcopenia And Intrinsic Capacity: Insights And Associations With All-Cause Mortality In The Toledo Study For Healthy Aging, Ivan Baltasar-Fernandez, Pedro L. Valenzuela, Irene Rodríguez-Gómez, Fabio Quiñonez-Bareiro, Luis M. Alegre, Konstantinos Prokopidis, Leocadio Rodriguez-Mañas, Ignacio Ara, Oscar Rosas-Carrasco, Lana J. Williams, Robinson Ramirez-Vélez, Julie A. Pasco, Guy Hajj-Boutros, Raman Agnihotram, Marc Sim, Wayne Lok Ok Choo, Mahdi Imani, Ana M. Ayala-Copete, Julia Chabot, Miguel G. Borda, Nailton J. Neto, Claire Godard-Sebillotte, Howard Bergman, Anna Andrianova, Hidenori Arai, Pierrette Gaudreau Jun 2026

The Interplay Between Osteosarcopenia And Intrinsic Capacity: Insights And Associations With All-Cause Mortality In The Toledo Study For Healthy Aging, Ivan Baltasar-Fernandez, Pedro L. Valenzuela, Irene Rodríguez-Gómez, Fabio Quiñonez-Bareiro, Luis M. Alegre, Konstantinos Prokopidis, Leocadio Rodriguez-Mañas, Ignacio Ara, Oscar Rosas-Carrasco, Lana J. Williams, Robinson Ramirez-Vélez, Julie A. Pasco, Guy Hajj-Boutros, Raman Agnihotram, Marc Sim, Wayne Lok Ok Choo, Mahdi Imani, Ana M. Ayala-Copete, Julia Chabot, Miguel G. Borda, Nailton J. Neto, Claire Godard-Sebillotte, Howard Bergman, Anna Andrianova, Hidenori Arai, Pierrette Gaudreau

Research outputs 2022 to 2026

Background: Osteosarcopenia—the coexistence of osteopenia/osteoporosis and sarcopenia—is associated with numerous adverse health outcomes, but its association with intrinsic capacity (IC) remains unknown. We aimed to explore the associations of osteosarcopenia with IC and all-cause mortality in older adults. Methods: We conducted a cross-sectional analysis of IC and a prospective analysis of all-cause mortality in 1142 participants from the Toledo Study for Healthy Aging (75.1 ± 6.0 years, 53.1% women). Participants were classified as having no musculoskeletal disorders, osteopenia/osteoporosis, sarcopenia, or osteosarcopenia (DXA- and EWGSOP2-based criteria). IC was operationalized as a composite score integrating locomotion, cognition, psychological, vitality, and sensory domains. …


Mitigating Disparities In Diagnosis Of Dementia, Lycia Tramujas Vasconcellos Neumann, Simin Mahinrad, Erin L. Abner, Soo Borson, Goldie S. Byrd, Maria Carrillo, Lindsay Clark, Anthony N. Correro Ii, Kacie D. Deters, Gladys E. Maestre Jun 2026

Mitigating Disparities In Diagnosis Of Dementia, Lycia Tramujas Vasconcellos Neumann, Simin Mahinrad, Erin L. Abner, Soo Borson, Goldie S. Byrd, Maria Carrillo, Lindsay Clark, Anthony N. Correro Ii, Kacie D. Deters, Gladys E. Maestre

School of Medicine Publications

The field of Alzheimer's disease and related dementias (AD/ADRD) is undergoing a transformative shift with a better understanding of disease biology, biomarker-based diagnostics, and disease-modifying therapies. Yet, these advancements risk exacerbating existing disparities in diagnosis and care. The 2024 Alzheimer's Association International Conference (AAIC) Advancements: Exploring Equity in Diagnosis convened interdisciplinary experts to address these inequities and chart a path toward population-generalizable research and practice. This article synthesizes key insights from the conference, highlighting considerations for inclusive and representative research design, ethical approaches in diagnostic disclosure, as well as challenges and solutions at individual, community, and systemic levels to advance …


Viscoelastic And Morphologic Changes In The Lumbar Intervertebral Discs Of The 5xfad Mouse Model Of Alzheimer's Disease, C E Gonzalez, C A Schurman, K A Wilson, B Schilling, L M Ellerby, S Y Tang Jun 2026

Viscoelastic And Morphologic Changes In The Lumbar Intervertebral Discs Of The 5xfad Mouse Model Of Alzheimer's Disease, C E Gonzalez, C A Schurman, K A Wilson, B Schilling, L M Ellerby, S Y Tang

2020-Current year OA Pubs

BACKGROUND: Chronic low back pain, commonly associated with intervertebral disc (IVD) degeneration, is highly prevalent in patients with Alzheimer's disease (AD), and the severity of the pain is correlated with the severity of the dementia. While incidences of both afflictions increase dramatically in the elderly population, it is unknown whether AD exacerbates the health of the IVD.

AIMS: The aim of this study is to examine how AD-related mutations affect the structure and mechanics of the IVD.

MATERIALS AND METHODS: Utilizing one-year-old male and female 5xFAD mice that constitutively express human APP and PSEN1 transgenes with five AD-linked mutations, we …


Updated Trends In The Global Prevalence And Burden Of Mental Disorders, 1990–2023: A Systematic Analysis For The Global Burden Of Disease Study 2023, Damian F. Santomauro, Paul Anthony Miller, Jamileh Shadid, Sarah Wulf Hanson, Anh Vo, Darius Jake Roy, Hailey Hagins, Ana M. Mantilla Herrera, James G. Scott, Holly E. Erskine, John J. Mcgrath, Hasan Aalruz, Hedayat Abbastabar, Nadin M.I. Abdel Razeq, Ahmed Abdelrahman Abdelgalil, Ali Abdolizadeh, Deldar Morad Abdulah, Abisola Esther Abdulmalik, Meklit Girma Abebe, Mesfin Abebe, Habtamu Abebe Getahun, Roberto Ariel Abeldaño Zuñiga, Olifan Zewdie Abil, Richard Gyan Aboagye, Shady Abohashem, Abdullahi Tunde Aborode, Moaz Elsayed Abouelmagd, Mohammad T. Abuawwad May 2026

Updated Trends In The Global Prevalence And Burden Of Mental Disorders, 1990–2023: A Systematic Analysis For The Global Burden Of Disease Study 2023, Damian F. Santomauro, Paul Anthony Miller, Jamileh Shadid, Sarah Wulf Hanson, Anh Vo, Darius Jake Roy, Hailey Hagins, Ana M. Mantilla Herrera, James G. Scott, Holly E. Erskine, John J. Mcgrath, Hasan Aalruz, Hedayat Abbastabar, Nadin M.I. Abdel Razeq, Ahmed Abdelrahman Abdelgalil, Ali Abdolizadeh, Deldar Morad Abdulah, Abisola Esther Abdulmalik, Meklit Girma Abebe, Mesfin Abebe, Habtamu Abebe Getahun, Roberto Ariel Abeldaño Zuñiga, Olifan Zewdie Abil, Richard Gyan Aboagye, Shady Abohashem, Abdullahi Tunde Aborode, Moaz Elsayed Abouelmagd, Mohammad T. Abuawwad

All Works

Background The 2023 iteration of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) estimated prevalence, incidence, and health burden for 375 diseases and injuries, including 12 mental disorders. We assess past, current, and emerging trends in the prevalence and burden of mental disorders across sexes and age groups, for 21 regions, 204 countries and territories, and by Socio-demographic Index (SDI) quintile, from 1990 to 2023. Methods Mental disorders included in GBD 2023 were anxiety disorders, major depressive disorder, dysthymia, bipolar disorder, schizophrenia, autism spectrum disorders, conduct disorder, attention-deficit hyperactivity disorder, anorexia nervosa, bulimia nervosa, idiopathic developmental intellectual …


Clinical Practice Guideline Emergency Department Discharge Acuity Scale To Improve Care Transitions, Charlisa Hedrick May 2026

Clinical Practice Guideline Emergency Department Discharge Acuity Scale To Improve Care Transitions, Charlisa Hedrick

Walden Dissertations and Doctoral Studies

No abstract provided.