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Articles 421 - 450 of 6172
Full-Text Articles in Entire DC Network
Restrictions On Veto Power: Holding The Permanent Five Accountable In The Face Of Intervention And Peacekeeping Operations, Theo Aldrighi
Restrictions On Veto Power: Holding The Permanent Five Accountable In The Face Of Intervention And Peacekeeping Operations, Theo Aldrighi
Dartmouth Undergraduate Journal of Politics, Economics and World Affairs
ABSTRACT: This article examines the structural constraints of the United Nations Security Council, with a focus on the veto power of its permanent members and its implications for intervention and peacekeeping. Through a realist lens and grounded in structural analysis, it contends that the recurrent paralysis of the Council in the face of mass atrocities stems from entrenched power asymmetries. The paper advances a bifold proposal: the adoption of the French-Mexican initiative to suspend veto use in cases of mass atrocities, and the entrenchment of the Council’s authority to authorize the use of force under defined conditions. Drawing on case …
Clickbait Economics: When Narratives Outshine Fundamentals, Esther Eisenstat
Clickbait Economics: When Narratives Outshine Fundamentals, Esther Eisenstat
Dartmouth Undergraduate Journal of Politics, Economics and World Affairs
No abstract provided.
Judicial Lustration In Backsliding Democracies: Causes And Solutions For Publication, Collin Mcdonnell
Judicial Lustration In Backsliding Democracies: Causes And Solutions For Publication, Collin Mcdonnell
Dartmouth Undergraduate Journal of Politics, Economics and World Affairs
No abstract provided.
Eco-Humanitarianism: A Political Ecological Framework For Humanitarian Resilience, Roksanna Keyvan
Eco-Humanitarianism: A Political Ecological Framework For Humanitarian Resilience, Roksanna Keyvan
Dartmouth Undergraduate Journal of Politics, Economics and World Affairs
No abstract provided.
Export Processing Zones: Misguided Vehicles Of Globalization, Isabella Calise
Export Processing Zones: Misguided Vehicles Of Globalization, Isabella Calise
Dartmouth Undergraduate Journal of Politics, Economics and World Affairs
No abstract provided.
The Effects Of A Geopolitical Policy—Case Study Of “Korea Limitation Order” Upon The Cultural Entertainment Industry In China, Zhilin Li
Dartmouth Undergraduate Journal of Politics, Economics and World Affairs
This paper examines the impact on the South Korean Cultural Entertainment Indus- try(CEI) of China’s “Korea Limitation Order”. In November 2016, Beijing restricted South Korean artists from holding concerts and the broadcast of South Korean TV dramas and banned cooperation between the two countries in the entertainment in- dustries. This paper focuses on the effect this had on exports of cultural products and relating industries from Korea, and how Korea was able to adjust to this geopolitical shock. I examine exports from Korea to China, Japan, and the United States using data from Cultural Entertainment Industry Products Exports, such as …
Development Analysis Of South Africa: Potential Impacts Of The Democratic Alliance’S Presence In The New Coalition, Mitchell Susswein
Development Analysis Of South Africa: Potential Impacts Of The Democratic Alliance’S Presence In The New Coalition, Mitchell Susswein
Dartmouth Undergraduate Journal of Politics, Economics and World Affairs
No abstract provided.
Does Bilingualism On Resumes Affect Callback Rates?, Autumn Halfpenny
Does Bilingualism On Resumes Affect Callback Rates?, Autumn Halfpenny
Dartmouth Undergraduate Journal of Politics, Economics and World Affairs
I study the influence of bilingualism in Spanish on the likelihood of receiving a callback for female customer service positions in the Chicago area. Data are collected from sixteen unique resumes submitted to 131 different job postings in an audit study, with applicants differing in bilingual ability. Bilingualism in Spanish significantly in- creases the likelihood of a callback by 17.86%-25.4%, implying bilingualism is valued in customer service roles. This suggests that bilingualism in Spanish may increase job prospects. While previous research studies this using observational and survey data, I use an audit study design with resumes to obtain causal results. …
Housing Construction In Washington, Dc: A Spatiotemporal Perspective, Willem Ells
Housing Construction In Washington, Dc: A Spatiotemporal Perspective, Willem Ells
Dartmouth Undergraduate Journal of Politics, Economics and World Affairs
No abstract provided.
The Effects Of Pandemic School Closures On Standardized Testing Outcomes: Evidence From Connecticut, Michael Manieri
The Effects Of Pandemic School Closures On Standardized Testing Outcomes: Evidence From Connecticut, Michael Manieri
Dartmouth Undergraduate Journal of Politics, Economics and World Affairs
During the Covid-19 pandemic, schools around the nation closed to prevent the virus’s spread. Following these closures, students’ performance on standardized exams worsened. Using a two-way fixed effect model with district and year fixed effects, I examine if the use of non-traditional schooling modes (i.e. hybrid and virtual) during the pandemic is associated with lower ELA and Math proficiency rates in Connecticut public schools. I find that Connecticut public school districts’ Math and ELA pass rates on the annual Smarter Balanced exam significantly decreased as they used higher levels of virtual and hybrid education. The magnitude of this decrease was …
Kind Kids, Healthy Teens: Child Prosociality And Fruit And Vegetable Intake, Farah Qureshi, Krista P. Woodward, Laura D. Kubzansky, Julia K. Boehm
Kind Kids, Healthy Teens: Child Prosociality And Fruit And Vegetable Intake, Farah Qureshi, Krista P. Woodward, Laura D. Kubzansky, Julia K. Boehm
Psychology Faculty Articles and Research
Introduction
Prosocial behaviors (i.e., being kind, caring, and cooperative) are believed to shape health and well-being starting in childhood. Yet, limited research has examined their long-term impact on health outcomes later in life. This study examined associations between childhood prosocial behaviors and fruit and vegetable consumption patterns across adolescence.Methods
Participants were from the United Kingdom Millennium Cohort Study (N=6,265). Caregivers reported children’s prosocial behaviors using the Strengths and Difficulties Questionnaire at ages 5 (2005–2007), 7 (2007–2009), and 11 (2011–2013) years. In 2024, Poisson regression was conducted to assess the associations between prosocial behaviors at age 5 years and sustained …Copper Oxide Nanoparticles As Delivery Vehicles For Different Pt (Ii)-Drugs: Experimental And Theoretical Evaluation, Shahdan Abdelkareem
Copper Oxide Nanoparticles As Delivery Vehicles For Different Pt (Ii)-Drugs: Experimental And Theoretical Evaluation, Shahdan Abdelkareem
Theses and Dissertations
Platinum(II)-based chemotherapeutic agents such as cisplatin, oxaliplatin, and nedaplatin are mainstays in the treatment of a wide range of solid tumors, yet their clinical application is severely restricted by rapid degradation, poor bioavailability, and dose-limiting side effects. These challenges arise in part from the drugs’ susceptibility to premature hydrolysis, off-target interactions in the bloodstream, and degradation in the gastrointestinal tract, which collectively limit their ability to reach and act on tumor cells. To address these limitations, we explored the use of copper(II) oxide nanoparticles (CuO NPs) as nanocarriers for platinum(II) drugs, aiming to enhance drug stability, loading, and controlled release. …
Eco-Emotions And Climate Activism In Adolescents, Julianna Sahoo
Eco-Emotions And Climate Activism In Adolescents, Julianna Sahoo
Master's Projects and Capstones
Background. Youth are especially vulnerable to climate change, both physically and psychologically. Combatting climate change will require a coordinated, global effort. Understanding the motivations and emotions behind climate activism is essential to coordinate efforts to combat climate change.
Methods. This research uses survey data collected from first and second year undergraduates (n=521) at a private, urban university in California in the Fall of 2022. Youth were surveyed on emotions related to climate change, activism, compassion, eco-anxiety, and well-being.
Results. Experiencing positive emotions had a stronger relationship with environmental activism compared to negative emotions.
Conclusion. Results suggest climate change communications should …
Enumerating Escherichia Coli (E. Coli) Concentrations And Evaluating Optical Brighteners As A Potential Indicator Of Human Wastewater Contamination In La Nana Bayou, Banita Creek, And Their Tributaries, Nacogdoches, Texas, Swastika Acharya, Matthew Mcbroom, Yuhui Weng, Yanli Zhang
Enumerating Escherichia Coli (E. Coli) Concentrations And Evaluating Optical Brighteners As A Potential Indicator Of Human Wastewater Contamination In La Nana Bayou, Banita Creek, And Their Tributaries, Nacogdoches, Texas, Swastika Acharya, Matthew Mcbroom, Yuhui Weng, Yanli Zhang
Electronic Theses and Dissertations
La Nana Bayou was added to the Texas 303(d) list in 2000 after it failed to meet water quality standards set by the Texas Commission on Environmental Quality (TCEQ) for primary contact recreation due to elevated Escherichia coli (E. coli) levels. E. coli is a bacterial species commonly found in the intestines of humans and warm-blooded animals. It serves as an indicator of fecal contamination in freshwater, though its presence alone cannot identify the contamination source. Optical brighteners (OBs), chemicals found in laundry detergents, cleaning agents, toilet papers, and clothing, are unique to human wastewater. This study aimed …
Role Of Patient-Reported Measures (Prms) In Addressing Ethical Challenges During Telemedicine Consultation: A Narrative Review, Asiya Attar, Kasturi Shukla
Role Of Patient-Reported Measures (Prms) In Addressing Ethical Challenges During Telemedicine Consultation: A Narrative Review, Asiya Attar, Kasturi Shukla
Patient Experience Journal
Introduction: Telemedicine has revolutionized medical care delivery by emphasizing on Patient-Centred Care (PCC). Patient Reported Measures (PRMs) can assist in providing PCC since it assesses the treatment outcomes and patient experience. However, using PRMs is not just limited to gauging clinical efficiency; it can also play a role in addressing the ethical challenges in telemedicine. Yet this aspect of PRMs remains underexplored. Method: Literature search was conducted using a combination of keywords from the Google Scholar, Scopus, and Web of Science databases. 126 peer-reviewed journal articles in English from 2015 to 2024 were screened, and 34 relevant full-text …
Engaging In Movement At Work: Exploring Engagement And Physical Activity., Spencer A. Cavan
Engaging In Movement At Work: Exploring Engagement And Physical Activity., Spencer A. Cavan
Electronic Theses and Dissertations
High levels of employee engagement provide organizations competitive advantages such as increased customer satisfaction, profits, and employee productivity. Despite potential benefits, the number of engaged employees is declining and organizations need to find innovative ways to enhance engagement. Emerging evidence suggests workplace physical activity may generate organizational benefits extending beyond health improvement. Therefore, the purpose of this study was to investigate perceptions of engagement among employees participating in a physical activity intervention at work. A qualitative design, guided by phenomenology, examined perceptions of workplace physical activity and perceived levels of engagement, as well as constraints related to involvement among university …
Exploring The Effect Of Social Determinants Of Health (Sdoh) Factors On The Time To Kidney Transplant Evaluation Completion For African American End Stage Renal Disease (Esrd) Patients, Kesha Levesque
MUSC Theses and Dissertations
Purpose – The purpose of this dissertation is to investigate the relationship between demographics and Social Determinants of Health (SDOH) variables on diagnostic testing time completion in patients being evaluated for kidney transplant waitlisting.
Aims - Compared to White Americans, African Americans who are eligible to receive a kidney transplant are less likely to complete the required testing in order to be placed on the kidney transplant waiting list which puts African Americans at risk for morbidity and mortality due to prolonged exposure to dialysis. The COVID-19 pandemic was directly associated with a decrease in the number of patients placed …
Social Cohesion, Trust, And Utilisation Of Maternal Health Services Among Refugee And Host Community Women In Bangladesh And Kenya, Haeun Lee, Ryan Rego, Neyat Fiseha, Ashok Barman, Nimo Sharif, Peninah Wachira, Joe Kolars, Akbar Waljee, Rubhana Raqib, Amina Abubakar
Social Cohesion, Trust, And Utilisation Of Maternal Health Services Among Refugee And Host Community Women In Bangladesh And Kenya, Haeun Lee, Ryan Rego, Neyat Fiseha, Ashok Barman, Nimo Sharif, Peninah Wachira, Joe Kolars, Akbar Waljee, Rubhana Raqib, Amina Abubakar
Institute for Human Development, East Africa
The global refugee crisis places significant pressure on host communities, particularly in low- and middle-income countries. Social cohesion and trust between refugee and host communities are critical for maternal health service utilisation. This study explores the relationship between host–refugee trust, social cohesion, and maternal health service use in Bangladesh and Kenya, focusing on facility-based delivery, antenatal care visits, and postnatal care attendance. To do so, a cross-sectional survey was administered among 649 refugee/displaced women and 371 host community women in the two locations. The results show high trust levels in both groups, while social cohesion is greater among refugee/displaced women. …
Advancing Point-Of-Care Diagnosis Of Joint Infection Using A Diffuse Reflectance Spectroscopy (Drs) System, Erin Elizabeth Drewke
Advancing Point-Of-Care Diagnosis Of Joint Infection Using A Diffuse Reflectance Spectroscopy (Drs) System, Erin Elizabeth Drewke
Graduate Theses and Dissertations
Septic arthritis is a severe joint infection that can rapidly destroy cartilage and cause lifelong disability if not diagnosed and treated promptly. Faster, bedside diagnostic tools are needed to reduce delays and support timely treatment decisions while preserving standard laboratory workflows. A syringe-mounted diffuse reflectance spectroscopy (DRS) system was developed for rapid, sterile, point-of-care measurement of synovial fluid optical properties. Broadband light (400–650 nm) was delivered and collected through the syringe barrel without contaminating the sample. An empirical lookup table (LUT) and a boundary-aware Monte Carlo (MC) model were implemented to extract absorption (μₐ) and reduced scattering (μs′) coefficients from …
Resilience Of Interdependent Transportation And Healthcare Systems: A Simulation-Driven Framework Incorporating Social Equity And Facility Optimization, S. Yasaman Ahmadi
Resilience Of Interdependent Transportation And Healthcare Systems: A Simulation-Driven Framework Incorporating Social Equity And Facility Optimization, S. Yasaman Ahmadi
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
The overarching goal of this dissertation is to develop an integrated, simulation-driven framework to assess and enhance the resilience of interdependent transportation and healthcare systems before, during, and after natural hazards. By examining how spatial disruptions, social vulnerability, operational constraints, and infrastructure interdependencies affect access to and functionality of hospitals, this research offers a multifaceted evaluation of system performance under stress. This dissertation examines the impact of natural hazards, particularly floods, on the interdependent transportation and healthcare systems. The proposed approach combines and advances GIS-based network analysis, graph-theoretical modeling, and discrete-event simulation to evaluate system performance under different scenarios. The …
Indigenous Gut Health, Tasha Vivier Morin
Indigenous Gut Health, Tasha Vivier Morin
Indigenous Health Student Publications
Indigenous gut health is a critical but often overlooked determinant of overall well-being. Gut health encompasses digestion, nutrient absorption, immune function, and the balance of the microbiome. Indigenous communities face unique challenges related to geography, food access, and the legacy of colonization, all of which affect dietary diversity and microbiome health. Drawing from the Health Belief Model, this project proposes a culturally responsive, education-based intervention to increase awareness of fiber-rich diets and their role in preventing chronic disease. The intervention aims to address upstream factors such as food access and health literacy, particularly among Indigenous families. Traditional diets once supported …
Evaluating The Impact Of Medicaid Expansion On Non-Small Cell Lung Cancer Care And Health Disparities, Marvin Idoteyin Okon
Evaluating The Impact Of Medicaid Expansion On Non-Small Cell Lung Cancer Care And Health Disparities, Marvin Idoteyin Okon
All Dissertations
Persistent disparities in non-small cell lung cancer (NSCLC) outcomes reflect broader structural inequities shaped by race, place, and socioeconomic conditions. This dissertation examined trends in NSCLC outcomes over the past two decades and evaluated the impact of Medicaid Expansion (ME) under the Affordable Care Act on improving outcomes and reducing disparities, especially in marginalized communities.
Using nationally representative datasets, three interrelated studies were conducted. The first assessed trends in NSCLC incidence, early-stage diagnosis, and 3-year survival from 2002-2021, stratified by metropolitan status, deprivation (Social Deprivation Index), and segregation (Index of Concentration at the Extremes). While incidence declined and early-stage diagnosis …
In A Safe-Space Of Her Own: Alice's Journey Through A Traumatized Wonderland To Find Attunement And Recovery, Cheston A. Axton
In A Safe-Space Of Her Own: Alice's Journey Through A Traumatized Wonderland To Find Attunement And Recovery, Cheston A. Axton
Electronic Theses and Dissertations
Throughout Alice’s Adventures in Wonderland/Through the Looking-Glass’s 160-year existence, Lewis Carroll’s seven-year-old protagonist has experienced many changes and alterations. With an ever-growing pop culture interest, Alice’s original narrative has undergone numerous adaptations, with each new variation diving deeper into the impact of trauma on Wonderland.
This thesis continues this existing discourse by examining Wonderland’s capacity to facilitate recovery in the aftermath of severe trauma. Through this research, the traumatic experiences of Alice, from Christina Henry’s The Chronicles of Alice: Alice and American McGee’s Alice: Madness Returns, are examined concerning their effect(s) on her construction of Wonderland, as …
The Global Neurodegeneration Proteomics Consortium: Biomarker And Drug Target Discovery For Common Neurodegenerative Diseases And Aging, Farhad Imam, Rowan Saloner, Jacob W Vogel, Varsha Krish, Gamal Abdel-Azim, Muhammad Ali, Lijun An, Federica Anastasi, David Bennett, Alexa Pichet Binette, Adam L Boxer, Martin Bringmann, Jeffrey M Burns, Carlos Cruchaga, Jeff L Dage, Amelia Farinas, Luigi Ferrucci, Caitlin A Finney, Mark Frasier, Oskar Hansson, Timothy J Hohman, Erik C B Johnson, Mika Kivimaki, Roxanna Korologou-Linden, Agustin Ruiz Laza, Allan I Levey, Inga Liepelt-Scarfone, Lina Lu, Niklas Mattsson-Carlgren, Lefkos T Middleton, Kwangsik Nho, Hamilton Se-Hwee Oh, Ronald C Petersen, Eric M Reiman, Oliver Robinson, Jeffrey D Rothstein, Andrew J Saykin, Artur Shvetcov, Chad Slawson, Bart Smets, Marc Suárez-Calvet, Betty M Tijms, Maarten Timmers, Fernando Vieira, Natalia Vilor-Tejedor, Pieter Jelle Visser, Keenan A Walker, Laura M Winchester, Tony Wyss-Coray, Chengran Yang, Niranjan Bose, Simon Lovestone, The Global Neurodegeneration Proteomics Consortium (Gnpc)
The Global Neurodegeneration Proteomics Consortium: Biomarker And Drug Target Discovery For Common Neurodegenerative Diseases And Aging, Farhad Imam, Rowan Saloner, Jacob W Vogel, Varsha Krish, Gamal Abdel-Azim, Muhammad Ali, Lijun An, Federica Anastasi, David Bennett, Alexa Pichet Binette, Adam L Boxer, Martin Bringmann, Jeffrey M Burns, Carlos Cruchaga, Jeff L Dage, Amelia Farinas, Luigi Ferrucci, Caitlin A Finney, Mark Frasier, Oskar Hansson, Timothy J Hohman, Erik C B Johnson, Mika Kivimaki, Roxanna Korologou-Linden, Agustin Ruiz Laza, Allan I Levey, Inga Liepelt-Scarfone, Lina Lu, Niklas Mattsson-Carlgren, Lefkos T Middleton, Kwangsik Nho, Hamilton Se-Hwee Oh, Ronald C Petersen, Eric M Reiman, Oliver Robinson, Jeffrey D Rothstein, Andrew J Saykin, Artur Shvetcov, Chad Slawson, Bart Smets, Marc Suárez-Calvet, Betty M Tijms, Maarten Timmers, Fernando Vieira, Natalia Vilor-Tejedor, Pieter Jelle Visser, Keenan A Walker, Laura M Winchester, Tony Wyss-Coray, Chengran Yang, Niranjan Bose, Simon Lovestone, The Global Neurodegeneration Proteomics Consortium (Gnpc)
Faculty, Staff and Student Publications
More than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years. Despite this growing burden, there are currently no cures, and treatment options remain limited due to disease heterogeneity, prolonged preclinical and prodromal phases, poor understanding of disease mechanisms, and diagnostic challenges. Identifying novel biomarkers is crucial for improving early detection, prognosis, staging and subtyping of these conditions. High-dimensional molecular studies in biofluids ('omics') offer promise for scalable biomarker discovery, but challenges in assembling large, diverse datasets hinder progress. To address this, the Global Neurodegeneration Proteomics Consortium (GNPC)-a public-private partnership-established one of the …
Exploring Adverse Childhood Experiences And Bullying Of Children Who Are Deaf Or Hard Of Hearing, Alyson Connelly Ward
Exploring Adverse Childhood Experiences And Bullying Of Children Who Are Deaf Or Hard Of Hearing, Alyson Connelly Ward
All Graduate Theses and Dissertations, Fall 2023 to Present
Adverse childhood experiences (ACEs) and bullying can lead to psychological distress, causing both short- and long-term health and mental health problems. Children with special healthcare needs (CSHCN), including those who are deaf or hard of hearing (DHH), face a higher risk of ACEs and bullying, which can affect their well-being.
This study builds on existing literature by (a) reviewing ACEs and bullying in CSHCN, especially those who are DHH, and (b) using data from the 2016-2022 National Survey of Children's Health to analyze ACEs and bullying in children who are DHH, DHH+CSHCN, and CSHCN. The literature review found that disability …
Bridging The Capacity Building Gap For Antimicrobial Stewardship Implementation: Evidence From Virtual Communities Of Practice In Kenya, Ghana, And Malawi, Ana De Lima, Kwame Buabeng, Mavis Sakyi, Hope Chadwala, Nicole Devereaux, Collins Mitambo, Christine Mugo-Sitati, Jennifer Njuhigu, Gunturu Revathi, Emmanuel Tanui
Bridging The Capacity Building Gap For Antimicrobial Stewardship Implementation: Evidence From Virtual Communities Of Practice In Kenya, Ghana, And Malawi, Ana De Lima, Kwame Buabeng, Mavis Sakyi, Hope Chadwala, Nicole Devereaux, Collins Mitambo, Christine Mugo-Sitati, Jennifer Njuhigu, Gunturu Revathi, Emmanuel Tanui
Pathology, East Africa
Background/Objectives: Strengthening antimicrobial stewardship (AMS) programs is an invaluable intervention in the ongoing efforts to contain the threat of antimicrobial resistance (AMR), particularly in low-resource settings. This study evaluates the impact of the Telementoring, Education, and Advocacy Collaboration initiative for Health through Antimicrobial Stewardship (TEACH AMS), which uses the virtual Extension for Community Healthcare Outcomes (ECHO) learning model to enhance AMS capacity in Kenya, Ghana, and Malawi. Methods: A mixed-methods approach was used, which included attendance data collection, facility-level assessments, post-session and follow-up surveys, as well as focus group discussions. Results: Between September 2023 and February 2025, 77 virtual learning …
A Global Movement Takes Shape – Physical Activity, Health, And The New Era Of Responsibility: “Global Alliance For Promotion Of Physical Activity”, J. M. Steinacker, W. Van Mechelen, C. Joisten, S. Zanuso, C. A. Jaworski, Y. P. Pitsiladis
A Global Movement Takes Shape – Physical Activity, Health, And The New Era Of Responsibility: “Global Alliance For Promotion Of Physical Activity”, J. M. Steinacker, W. Van Mechelen, C. Joisten, S. Zanuso, C. A. Jaworski, Y. P. Pitsiladis
Research outputs 2022 to 2026
No abstract provided.
'Managed Hearts’ In Helper-Education: Gender Non-Binary Helper-Educators’ Experiences Of Emotional Labor, Jordan Pearce
'Managed Hearts’ In Helper-Education: Gender Non-Binary Helper-Educators’ Experiences Of Emotional Labor, Jordan Pearce
Counseling & Human Services Theses & Dissertations
The unique experiences of people who identify with a gender beyond the binary paradigm dominant in the Global West are not well understood. The literature provides little insight into the experiences and perspectives of these individuals in a variety of contexts, including in their workplaces. As various social movements collide, they bring amplified attention to the mental health of marginalized communities and to workers, as well as the dynamics of modern work environments, and the specific needs of certain individuals doing certain types of work. The current study explored the experiences of gender non-binary individuals (GNI) working as helper-educators engaged …
Master Protocol Design With Hybrid Control For Efficient Early-Phase Trial Consolidation, Alexander M Kaizer, Xiaojiang Zhan, Eric Baron, Rui Sammi Tang, David S Hong, Brian P Hobbs
Master Protocol Design With Hybrid Control For Efficient Early-Phase Trial Consolidation, Alexander M Kaizer, Xiaojiang Zhan, Eric Baron, Rui Sammi Tang, David S Hong, Brian P Hobbs
Faculty, Staff and Student Publications
Purpose: Master protocols represent transformations, enabling multiple therapies or diseases under a single protocol. These designs streamline therapeutic development by reducing redundancies. Suited for evolving fields such as oncology and global emergencies such as the COVID-19 pandemic, master protocols have been exemplified by studies such as RECOVERY, Solidarity, and I-SPY 2, which accelerated effective treatment identification (with I-SPY 2 focused on molecular subtypes). Recent oncology examples, such as MORPHEUS, evaluate immunotherapy combinations with shared controls. Despite advantages, their application in early-phase oncology remains underutilized amid growing regulatory emphasis on randomization for robust evidence.
Methods: US Food and Drug Administration (FDA) …
Implementation Outcomes Of A Patient Decision-Aid In A Diverse Population With Systemic Lupus Erythematosus In 15 Us Rheumatology Clinics, Jasvinder A Singh, Larry R Hearld, Seth Eisen, W Winn Chatham, Sonali Narain, Narender Annapureddy, Diane L Kamen, Kimberly Trotter, Vikas Majithia, Cathy Lee Ching, Zineb Aouhab, Swamy Venuturupalli, Daniel J Wallace, Rosalind Ramsey-Goldman, Alfred Kim, Maureen Mcmahon, S Sam Lim, Kalpana Bhairavarasu, Alexa Meara, Kenneth Kalunian, T Mark Beasley
Implementation Outcomes Of A Patient Decision-Aid In A Diverse Population With Systemic Lupus Erythematosus In 15 Us Rheumatology Clinics, Jasvinder A Singh, Larry R Hearld, Seth Eisen, W Winn Chatham, Sonali Narain, Narender Annapureddy, Diane L Kamen, Kimberly Trotter, Vikas Majithia, Cathy Lee Ching, Zineb Aouhab, Swamy Venuturupalli, Daniel J Wallace, Rosalind Ramsey-Goldman, Alfred Kim, Maureen Mcmahon, S Sam Lim, Kalpana Bhairavarasu, Alexa Meara, Kenneth Kalunian, T Mark Beasley
Faculty, Staff and Students Publications
Objective: The objective of this study was to examine the clinical outcomes during the implementation of a self-administered patient decision-aid (PtDA) for lupus.
Methods: We provided an effective computerized lupus PtDA in 15 rheumatology outpatient clinics 2019-2024 (including the COVID pandemic). We undertook Organizational Readiness to Implement Change Surveys (ORICs) and Team Learning and Psychological Safety Surveys (TLPSSs) at baseline. The primary study outcome objective measure, percent penetration/reach, was defined as the number of patients who viewed the lupus PtDA at the end of the study, divided by the total number of eligible patients (times 100). We used validated clinical …