Digital Commons Network^™

Gut Microbiome Alterations Associated With Diabetes In Mexican Americans In South Texas, Suet-Ying Kwan, Caroline M Sabotta, Aron Joon, Peng Wei, Lauren E Petty, Jennifer E Below, Xiaogang Wu, Jianhua Zhang, Robert R Jenq, Ernest T Hawk, Joseph B Mccormick, Susan P Fisher-Hoch, Laura Beretta

Faculty, Staff and Student Publications

Mexican Americans have a high prevalence of diabetes and burden of diabetes-related complications, highlighting the need for novel preventive strategies and noninvasive predictors of diabetes risk tailored to this population. Changes in the gut microbiome have the potential to predict diabetes. Here, we aimed to identify alterations in the gut microbiome associated with diabetes in the high-risk population of Mexican Americans in South Texas. Stool samples were collected from 216 subjects from the population-based Cameron County Hispanic Cohort. Among them, 75 had type 2 diabetes. Taxonomic and functional profiling of the stool samples were assessed by 16S and shotgun metagenomic …

Characterizing And Explaining Prevalence And Factors Associated With Non-Fatal Opioid Overdose In Florida, Jesse M. Bell

USF Tampa Graduate Theses and Dissertations

Many factors contribute to the opioid epidemic in Florida, including, but not limited to, physician over prescribing, opioid manufacturer malfeasance (direct marketing to physicians, hospitals, and universities, as well indirect political contributions, and deliberately obfuscating the impact of the addictive properties of their various drugs), and as the epidemic approaches its 25th year, sociodemographic characteristics. This body of work examines three of these. First, because an opioid naïve persons’ typical initial encounter with the drug is through a physician, we sought to shed light on the impact of direct pharmaceutical marketing to physicians. We identified opioid providing physicians from the …

Rainbow Perfect And Near-Perfect Matchings In Complete Graphs With Edges Colored By Circular Distance, Shuhei Saitoh, Naoki Matsumoto, Wei Wu

Theory & Applications of Graphs

Given an edge-colored complete graph K_n on n vertices, a perfect (respectively, near-perfect) matching M in K_n with an even (respectively, odd) number of vertices is rainbow if all edges have distinct colors. In this paper, we consider an edge coloring of K_n by circular distance, and we denote the resulting complete graph by K^●_n. We show that when K^●_n has an even number of vertices, it contains a rainbow perfect matching if and only if n=8k or n=8k+2, where k is a nonnegative integer. In the case of an odd …

Inhibitory Control Of Emotional Interference In Deaf Children: Evidence From Event-Related Potentials And Event-Related Spectral Perturbation Analysis, Qiong Chen, Junfeng Zhao, Huang Gu, Xiaoming Li Ph.D.

Faculty Publications

Background: Impairment of interference control ability may reflect a more general deficit in executive functioning, and lead to an increase in internal-externalized problems such as impulsivity, which has been reported in deaf children. However, few researches have examined the neural mechanism of this impairment.

Methods: This study applied the electroencephalogram (EEG) technique to investigate the interference control ability in 31 deaf children and 28 hearing controls with emotional face-word stroop task.

Results: Results from behavioral task showed that deaf children exhibited lower accuracy compared to hearing controls. As for EEG analysis, reduced activation of ERP components in N1 and enhanced …

Junk Food Accessibility After 10 Years Of A Restrictive Food Environment Zoning Policy Around Schools, Lindsey Soon, Jason Gilliland, Leia M. Minaker

Geography & Environment Publications

Zoning has been proposed as a way of reducing unhealthy food access for youth, but little research has evaluated outcomes of proposed or existing junk food bans, and even less research has considered equity implications of such zoning policies. In this simulation study, set in the Region of Waterloo, Ontario (Canada), we examined how secondary student access to fast food restaurants and convenience stores would change under such a policy over 10 years in a mid-sized Canadian municipality. Outcomes are presented by school-level advantage (derived from the proportion of students in equity-deserving subgroups: low income, students who speak English …

Rural-Urban And Within-Rural Differences In Covid-19 Mortality Rates, Yue Sun, Kent Jason G. Cheng, Shannon M. Monnat

Journal of Rural Social Sciences

Since late-2020, COVID-19 mortality rates have been higher in rural than in urban America, but there has also been substantial within-rural heterogeneity. Using CDC data, we compare COVID-19 mortality rates across the rural-urban continuum as well as within rural counties across different types of labor markets and by metropolitan adjacency. As of October 1, 2021, the cumulative COVID-19 mortality rate was 247.0 per 100,000 population in rural counties compared to 200.7 in urban counties. Higher COVID-19 mortality rates in rural counties are explained by lower average educational attainment and lower median household income. Within rural counties, mortality rates have been …

The Burden Of Short-Term Major Adverse Cardiac Events And Its Determinants After Emergency Percutaneous Coronary Revascularization: A Prospective Follow-Up Study, Rajesh Kumar, Jehangir Ali Shah, Bashir Ahmed Solangi, Ali Ammar, Mukesh Kumar, Naveedullah Khan, Jawaid Akbar Sial, Tahir Saghir, Nadeem Qamar, Musa Karim

Journal of the Saudi Heart Association

Objectives: Primary percutaneous coronary intervention (PCI) remains recommended reperfusion therapy for patients with acute ST-elevation myocardial infarction. This study aimed to evaluate the short-term major adverse cardiac events (MACE) and their determinants among patients who underwent primary PCI at a tertiary care cardiac center of Karachi, Pakistan. Methods: A cohort of patients who underwent primary PCI were followed for the MACE. Multivariable Cox-regression analysis was performed with backward conditional variable selection and hazard ratio (HR) along with 95% confidence interval (CI) were obtained. Results: A total of 1150 patients were included, of which follow-up was successful in 95.8% (1102) and …

Association Of Medicaid Expansion With Emergency Department Visits By Medical Urgency, Theodoros V. Giannouchos, Benjamin Ukert, Christina Andrews Ph.D.

Faculty Publications

Importance Relatively little is known about the association of the Medicaid eligibility expansion under the Patient Protection and Affordable Care Act with emergency department (ED) visits categorized by medical urgency.

Objective To estimate the association between state Medicaid expansions and ED visits by the urgency of presenting conditions.

Design, Setting, and Participants This cross-sectional study used the Healthcare Cost and Utilization Project State Emergency Department Databases from January 2011 to December 2017 for 2 states that expanded Medicaid in 2014 (New York and Massachusetts) and 2 states that did not (Florida and Georgia). Difference-in-differences regression models were used to estimate …

Social Determinants Of Health Influence Outcomes In Patients Undergoing Total Hip Arthroplasty: A Systematic Review, Varag Abed Bs, Daisy Ference Ba, Alex Duvall Ba, Ajith Dupati Bs, Joshua Castle Md, Eric Makhni Md/Mba

Medical Student Research Symposium

Purpose: To examine the effects of social determinants of health (SDOH) on patient outcomes following total hip arthroplasty (THA)

Methods: A systematic search was conducted using the MEDLINE, Epub Ahead of Print, Web of Science, PubMed and Embase databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to find studies involving at least 1 SDOH and its effects on patient reported outcomes and surgical outcomes following THA. 2,840 studies were initially identified and we are still in the process of determining which studies will eventually meet the criteria regarding SDOH influencing postoperative THA outcomes.

Results: …

“I’M Going To Live My Life Freely”: Authenticity As An Indicator Of Belonging Among Urban Latinx Lgbtq+ Youth, Maru Gonzalez, Bianka M. Reese, Tania Connaughton-Espino

Journal of Human Sciences and Extension

While there is a growing body of scholarship on the experiences of LGBTQ+ youth in school and community settings, less is known about Latinx LGBTQ+ youth specifically. In response, this phenomenological study examined the experiences of eight Latinx LGBTQ+ youth relative to school and community belonging, with a specific focus on urban environments, using intersectionality and minority stress frameworks, and Lee and Robbins’ operational definition of belongingness. Three overarching themes emerged from the data: (a) navigating challenges, (b) the importance of an inclusive climate, and (c) thriving through adversity. Further, authenticity was identified as an additional indicator of belonging among …

Understanding The Efficacy Of Telehealth In Pediatric Occupational Therapy, Katheren Bettermann

University Honors Theses

In response to the COVID-19 pandemic, the American Occupational Therapy Association (AOTA) expanded telehealth, an electronic health care service, to virtually treat patients. Many occupational therapy and public health scholars are researching the effectiveness of telehealth for all age groups or for adults only. The purpose of this study is to understand the efficacy of telehealth as a pediatric occupational therapy modality and expose variables effecting treatment quality.

I created a survey in Qualtrics, a web-based software. The target population was pediatric occupational therapists (OTs) licensed in Oregon. Qualitative and quantitative questions addressed respondent qualifications, telehealth and pediatric occupational therapy …

Visualizing Diversity: Spatial Data As A Resource Enabling Extension To Better Engage Communities, Justin Krohn, Jacqueline Davis-Manigaulte, Christopher Fulcher, Jennifer Sarah Tiffany

Journal of Human Sciences and Extension

Effective Extension programming relies on engaging people of all races, ethnicities, and cultures. Extension educators sometimes struggle with how best to engage communities that are not “traditional” program audiences. Centering data visualization on the strength of Black, Latino/Hispanic, Asian, Native American, and other potentially marginalized communities can assist Extension’s work to engage diverse staff, program participants, and advisory board members. For example, using maps to understand what languages people speak at home strengthens the connections between Extension programs and community participants and can inform staff recruitment and advisory board composition. However, maps of aggregated areas like counties can mask socioeconomic …

Cooperative Extension In Urban America: Place-Based Approaches For Improving Health, Dawn Burton, Latoya O'Neal, Erin Yelland, Suzanne Stluka, Rodger Rennekamp

Journal of Human Sciences and Extension

While the bulk of Cooperative Extension’s (Extension) historical work has been with rural populations, its future work should also address the needs of those living in urban areas. The opportunity to live a long and healthy life is paramount among those needs. Cooperative Extension’ National Framework for Health Equity and Well-Being (Framework) provides a roadmap by which Cooperative Extension can help ensure that all people have that opportunity. The central premise of the Framework is that future work of Extension must include but extend beyond the promotion of healthy behaviors to place-based approaches for improving conditions in which people live, …

Fostering A Sense Of Belonging In Urban Extension For Internal And External Stakeholders, Ramona Madhosingh-Hector, Linda M. Seals

Journal of Human Sciences and Extension

In urban areas, the communities are as diverse as the issues, and different educational and engagement strategies must be deployed to support urban Extension clientele. Urban communities must connect with and feel a sense of “belonging” with Extension–this connection can strengthen Extension’s presence and value proposition to urban constituents. This study found that although Extension was engaged in efforts to support belonging, its efforts were hampered by a lack of collaboration and commitment to supporting a system-wide effort to change the culture. Intentionality, emotional intelligence, and dialogue were presented as strategies to foster a sense of belonging for Extension personnel …

Temporal Changes In Gastrointestinal Fungi And The Risk Of Autoimmunity During Early Childhood: The Teddy Study, Thomas A Auchtung, Christopher J Stewart, Daniel P Smith, Eric W Triplett, Daniel Agardh, William A Hagopian, Anette G Ziegler, Marian J Rewers, Jin-Xiong She, Jorma Toppari, Åke Lernmark, Beena Akolkar, Jeffrey P Krischer, Kendra Vehik, Jennifer M Auchtung, Nadim J Ajami, Joseph F Petrosino

Faculty, Staff and Students Publications

Fungal infections are a major health problem that often begin in the gastrointestinal tract. Gut microbe interactions in early childhood are critical for proper immune responses, yet there is little known about the development of the fungal population from infancy into childhood. Here, as part of the TEDDY (The Environmental Determinants of Diabetes in the Young) study, we examine stool samples of 888 children from 3 to 48 months and find considerable differences between fungi and bacteria. The metagenomic relative abundance of fungi was extremely low but increased while weaning from milk and formula. Overall fungal diversity remained constant over …

The Phylogeny Of Rays And Skates (Chondrichthyes: Elasmobranchii) Based On Morphological Characters Revisited., Eduardo Villalobos-Segura, Giuseppe Marramà, Giorgio Carnevale, Kerin M. Claeson, Charlie J Underwood, Gavin J P Naylor, Jürgen Kriwet

PCOM Scholarly Works

Elasmobranchii are relatively well-studied. However, numerous phylogenetic uncertainties about their relationships remain. Here, we revisit the phylogenetic evidence based on a detailed morphological re-evaluation of all the major extant batomorph clades (skates and rays), including several holomorphic fossil taxa from the Palaeozoic, Mesozoic and Cenozoic, and an extensive outgroup sampling, which includes sharks, chimaeras and several other fossil chondrichthyans. The parsimony and maximum-likelihood analyses found more resolved but contrasting topologies, with the Bayesian inference tree neither supporting nor disfavouring any of them. Overall, the analyses result in similar clade compositions and topologies, with the Jurassic batomorphs forming the sister clade …

Weight Loss For Overweight And Obese Patients With Prostate Cancer: A Study Protocol Of A Randomised Trial Comparing Clinic-Based Versus Telehealth Delivered Exercise And Nutrition Intervention (The Telex Trial), Daniel A. Galvão, Dennis R. Taaffe, Dickon Hayne, Pedro Lopez, Philippa Lyons-Wall, Colin I. Tang, Suzanne K. Chambers, Amanda Devine, Nigel Spry, Emily Jeffery, Christine Kudiarasu, David Joseph, Robert U. Newton

Research outputs 2022 to 2026

Introduction Obese men with prostate cancer have an increased risk of biochemical recurrence, metastatic disease and mortality. For those undergoing androgen deprivation therapy (ADT), substantial increases in fat mass are observed in the first year of treatment. Recently, we showed that a targeted supervised clinic-based exercise and nutrition intervention can result in a substantial reduction in fat mass with muscle mass preserved in ADT-treated patients. However, the intervention needs to be accessible to all patients and not just those who can access a supervised clinic-based programme. The purpose of this study was to evaluate the efficacy of telehealth delivered compared …

Examining Elementary School Children’S Knowledge About Food And Nutrition In Southwestern Ontario, Canada, Paige Colley, Jamie A. Seabrook, Sarah J. Woodruff, Jason Gilliland

Geography & Environment Publications

Purpose: Knowledge is fundamental to helping children make nutritional choices that support lifelong healthy behaviours. This study (i) investigates elementary school children’s knowledge about food and nutrition and (ii) identifies sociodemographic factors influencing children’s reported knowledge. Methods: In 2017–2019, a survey was administered to 2443 students (grades 5–8) at 60 schools across southwestern Ontario, Canada, and a parent survey was used to validate self-reported sociodemographics. Multiple regression was used to analyse children’s knowledge scores and related sociodemographic factors. A total knowledge score was calculated by summing correct responses derived from 46 individual questions in the student …

Assessment Of Spatial And Temporal Trends Of Exposure To Ambient Fine Particulate Matter And Ozone In New York/New Jersey Metropolitan Area, Subraham Singh

Dissertations and Theses

Background. Exposures to fine particulate matter (PM_2.5; particles with diameter less than 2.5 μm) and ozone (O₃) affect premature respiratory and cardiovascular mortality, morbidity and contribute to the development and progression of sub-clinical and clinical disease. Climate change affects air quality directly by modifying the thermodynamic properties of formation mechanisms and transport patterns, and indirectly, through increased emissions of PM_2.5 and O₃ precursors. The resultant changes in air quality influence human health outcomes through mechanisms of varying scale, timing, and complexity. PM_2.5 and O₃ levels have been declining due to the implementation …

Investigation Of The Association Of Exposures To Fire-Related Hazards With Pulmonary Function Of Firefighters, David G. Goldfarb

Dissertations and Theses

Background. Firefighters are habitually exposed to hazardous toxicants which place them at an elevated risk for numerous adverse health outcomes. An example of this is the associations observed in other works between inhalation of combustion byproducts from urban structural fires and both acute and chronic pulmonary dysfunction. To-date, the characterization of firefighters’ exposures to dangerous chemicals in smoke from non-wildfire incidents, both directly through personal monitoring and indirectly from work-related records is scarce. Prior works investigating the association between routine firefighting and pulmonary function have relied on crude metrics such as years of service and numbers of responses to …

Epilepsy Research In Africa: A Scoping Review By The Ilae Pediatric Commission Research Advocacy Task Force, Pauline Samia, Jane Hassell, Jessica Hudson, Azim Ahmed, Jasmit Shah, Charles Hammond, Edward Kija, Stéphane Auvin, Jo Wilmshurst

Paediatrics and Child Health, East Africa

Objective: Despite the high prevalence of epilepsy in Africa, evaluation of epi- lepsy research trends on the continent is lacking. Without establishing effective research, improvement in care for people with epilepsy cannot be effectively strategized or targeted.

Methods: A scoping review of the peer-reviewed literature on epilepsy from Africa (1989–2019) was conducted. The aim was to understand from this what areas are well researched versus underresearched based on published epilepsy topics.

Results: A total of 1227 publications were identified and assessed. A significant increase in publications occurred over the 30 years assessed. African author lead- ership was …

Covid-19 And Transition To Distance Learning: Perspectives Of Postsecondary Teachers In Kenya, James Ogechi Kereri, Grace Moraa Kennedy, Dovison Kereri

Faculty Publications

Several countries have transitioned to online and/or virtual learning to minimize the impact of Covid-19 on education. In Kenya, schools were closed for the better part of 2020 and reopened back on relying on an online mode and/or virtual learning. However, very little is known about the impact of such transition on postsecondary educators. Therefore, this research aims to bridge this gap by investigating the impact of online and/or virtual learning transition on postsecondary educators based on age, gender, location, and academic rank. Using a nationally distributed web-based survey, the study utilized data from 117 educators across Kenya who participated …

Assessing Psychosocial Factors That Influence Water, Sanitation, And Hygiene Behavior In The Amhara Region Of Ethiopia, Kimberly Kamara

Dissertations and Theses

Background: The absence of potable drinking water from an improved source combined with inadequate sanitation and hygiene contributed to an estimated 1.9% of the global burden of disease in 2016. The estimated number of diarrheal deaths in 2016 was 1.4 million, of which 829,000 could have been prevented through improved drinking water and sanitation services, and hand-washing with soap. Despite the clear link between poor water and sanitation access and hygiene practices, 785 million people do not have access to water and two million do not have access to basic sanitation services. However, access does not automatically result in increased …

Medicinal Plant Use For Type-2 Diabetes Treatment In The Traditional Vietnamese Medicine System Of Southern Vietnam, Lan Truong

Dissertations, Theses, and Capstone Projects

This ethnobotanical study examines the traditional health care system of the Mekong River Delta in Vietnam. The basic inquiry focuses on how the healers in the traditional Vietnamese medicine (TVM) system are treating a disease relatively new in Vietnam, type-2 diabetes (T2D). The study includes a description of the system in which the healers work. The research design compares two locations, one on the mainland (Rạch Giá City) and the other on a nearby island (Phú Quốc Island).

There are six chapters. The first chapter establishes foundational information about the region, population, and the traditional medical system. The results of …

Effectiveness Of Telemental Health Services In Rural Communities, Elizabeth Vebangsi

Doctoral Dissertations and Projects

Telemental health has been recognized as a technique to improve access to care delivered to Rural communities and those willing to use telehealth services have increased tremendously since its introduction. Literature evaluates patients’ satisfaction with telemental health services and their acceptance to improve care delivery in rural communities. The literature review identified three major themes: improved care, increased use of telemental health services, and reduced cost and timesaving. Even though some studies uncovered issues from technology, poor connectivity, and delay in audio-visual transmission, the potential of mental health services continues to enhance care delivery to rural communities.

Modelmatcher: A Scientist-Centric Online Platform To Facilitate Collaborations Between Stakeholders Of Rare And Undiagnosed Disease Research, J Michael Harnish, Lucian Li, Sanja Rogic, Guillaume Poirier-Morency, Seon-Young Kim, Kym M Boycott, Michael F Wangler, Hugo J Bellen, Philip Hieter, Paul Pavlidis, Zhandong Liu, Shinya Yamamoto

Duncan NRI Faculty and Staff Publications

Next-generation sequencing is a prevalent diagnostic tool for undiagnosed diseases and has played a significant role in rare disease gene discovery. While this technology resolves some cases, others are given a list of possibly damaging genetic variants necessitating functional studies. Productive collaborations between scientists, clinicians, and patients (affected individuals) can help resolve such medical mysteries, and provide insights into in vivo function of human genes. Furthermore, facilitating interactions between scientists and research funders, including non-profit organizations or commercial entities, can dramatically reduce the time to translate discoveries from bench to bedside. Several systems designed to connect clinicians and researchers with …

Inequalities In Antenatal Care In Ghana, 1998–2014, Abdul-Aziz Seidu, Joshua Okyere, Eugene Budu, Henry Ofori Duah, Bright Opoku Ahinkorah

College of Nursing Faculty Research and Publications

Background

In order to effectively and efficiently reduce maternal mortality and ensure optimal outcomes of pregnancy, equity is required in availability and provision of antenatal care. Thus, analysis of trends of socio-economic, demographic, cultural and geographical inequities is imperative to provide a holistic explanation for differences in availability, quality and utilization of antenatal care. We, therefore, investigated the trends in inequalities  in four or more antenatal care visits in Ghana, from 1998 to 2014.

Methods

We used the World Health Organization’s (WHO) Health Equity Assessment Toolkit (HEAT) software to analyse data from the 1998 to 2014 Ghana Demographic and Health …

Weakly-Supervised Tumor Purity Prediction From Frozen H&E Stained Slides, Matthew Brendel, Vanesa Getseva, Majd Al Assaad, Michael Sigouros, Alexandros Sigaras, Troy Kane, Pegah Khosravi, Juan Miguel Mosquera, Olivier Elemento, Iman Hajirasouliha

Publications and Research

Background

Estimating tumor purity is especially important in the age of precision medicine. Purity estimates have been shown to be critical for correction of tumor sequencing results, and higher purity samples allow for more accurate interpretations from next-generation sequencing results. Molecular-based purity estimates using computational approaches require sequencing of tumors, which is both time-consuming and expensive.

Methods

Here we propose an approach, weakly-supervised purity (wsPurity), which can accurately quantify tumor purity within a digitally captured hematoxylin and eosin (H&E) stained histological slide, using several types of cancer from The Cancer Genome Atlas (TCGA) as a proof-of-concept.

Findings

Our model predicts …

Design Of Self-Assembled Peptides For Wound Healing, Ka-Kyung Kim

Dissertations

According to the CDC, 15% of diabetic patients develop diabetic foot ulcers (DFU) and approximately 170,000 patients undergo non-traumatic amputation annually. DFU is a major complication of diabetes caused by non-healing full-thickness wounds through the dermis. The current treatments include blood sugar control, frequent debridement, offloading, moist wound care, infection treatment, and amputation. To achieve wound closure of DFU, appropriate wound care and antibiotic therapy are essential. Topical regimens include hydrocolloids, alginates, foam, silver-impregnated dressings, and hydrogels. Wound healing is a complex and dynamic interplay between the immune system, keratinocytes, and dermal cells (in case of cutaneous wound). Angiogenesis has …

Actions Against Racism: Bringing Together Trauma-Informed Practices, Social-Emotional Learning, And Racial Socialization To Combat Racism In Schools, Danielle R Hatchimonji, Kira Branch, Danika Perry, Tia N Barnes

Department of Pediatrics Faculty Papers

Racism is a social determinant of health with dire consequences for the health, education, and mental health of students of color. Thus, there is an urgent need to develop and test evidence-based strategies to combat racism in schools. In response to this need, our team has developed a multi-tiered school-based intervention to build capacity for combatting racism in educators, students, and families. The "Actions Against Racism" intervention synthesizes three evidence-based practices: trauma-informed practices, social-emotional learning (SEL), and racial socialization. The multiple tiers of intervention aim to cultivate skills for combatting individual and structural racism in educators, families, and students across …