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Efficacy Of Cognitive Therapy And Pharmacotherapy In Depression: A Meta-Analysis, Daniel B. Michel

Loma Linda University Electronic Theses, Dissertations & Projects

A meta-analysis comparing the long-term effectiveness of cognitive behavioral therapy (CBT) and pharmacotherapy in preventing relapse following treatment discontinuation was performed using published studies of depressed participants. Twenty-three articles met inclusionary criteria and were included in the analyses. Weighted effect sizes and moderators, treatment type, were calculated using statistical analysis software. Initially, fixed effects models were applied to the data, but due to significant between-group heterogeneity that could not be fully explained by treatment type, mixed effect models were used to account for the residual heterogeneity. Results indicated that overall, depressed individuals treated to remission with CBT evidence decreased relapse …

Distraction Of Heterotopic Bone Formed With Bmp-2 In A Rat Model: The Technique, Stacie Dawn Fenderson

Loma Linda University Electronic Theses, Dissertations & Projects

Multiple studies have shown that ectopic bone forms when bone morphogenic proteins (for example BMP-2 and BMP-7) and a collagen matrix are surgically placed in a rat model either orthotopically or heterotopically. Bone begins to form by the 14 day, and is at it maximum calcified state by the 21st day. The purpose of this study is to observe and quantify the effect of distraction osteogenesis on the ectopic bone. First, a preliminary procedure was performed by surgically placing a titanium cage into the back of a rat just caudal to the thoracic vertebrae. The anterior corners were sutured to …

Immediate Implant Placement In Extraction Sites With Periapical Lesions: A Retrospective Study, Yuan-Lung Hung

Loma Linda University Electronic Theses, Dissertations & Projects

Immediate implant placement into fresh extraction sites has become a relatively routine clinical procedure with a favorable prognosis. However, immediate placement into extraction sockets with lesions has not been extensively documented in humans. Therefore, the purpose of this study was to retrospectively determine the survival rate of implants placed into extraction sockets with visible periapical lesions.

Patient charts of 544 immediately placed implants from Loma Linda University School of Dentistry, Center for Prosthodontics and Implant Dentistry were examined. Eighty-six of the 544 implants had been placed immediately into extraction sockets with periapical lesions and they were included in this study. …

Is Electrical Stimulation A Predictive Tool For Autonomic Dysfunction In Males With Diabetes?, Susan Dorothy Rand

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to examine whether electrical stimulation can be used as a predictive tool to assess autonomic dysfunction in males with diabetes. The study was designed to better understand the extent of autonomic nervous system (ANS) dysfunction in the diabetic population.

Controls and patients with diabetes were recruited from the community at large and the Loma Linda University Diabetes Treatment Center and were managed by a physician. Twelve (12) people with diabetes and thirteen (13) control subjects participated. Mean age (years) for people with diabetes was 52.4 +/- 6.1 and 47.2 +/-11.1 for controls (p =0.05). …

The Effects Of The Quadhelix Appliance On The Dentition And Adjacent Buccal Bone, Shannon Hilgers

Loma Linda University Electronic Theses, Dissertations & Projects

Maxillary palatal expansion has long been used in orthodontics as a means of correcting constricted and collapsed dental arches. The quadhelix appliance, developed by Drs. Robert Ricketts and Ruel Bench, expands buccal segments and causes distobuccal rotation in upper first molars. The objective of this study was to assess the direct effects that the quadhelix appliance on the surrounding dentition and buccal bone in the maxillary premolar and molar areas in a finite, measurable manner. This assessment was made using the NewTom 3G. The pre-quadhelix and post-quadhelix NewTom 3G images of twenty patients treated in the Graduate Orthodontic Clinic at …

Renal Cell Carcinoma Metastatic To The Duodenum: Treatment By Classic Pancreaticoduodenectomy And Review Of The Literature, Robert Adamo, Patrick J. Greaney Jr., Agnieszka Witkiewicz, Eugene P. Kennedy, Charles J. Yeo

Department of Surgery Faculty Papers

Renal cell cancer (RCC) most commonly metastasizes to the lungs, bones, liver, renal fossa, and brain, although metastases can occur elsewhere. RCC metastatic to the duodenum is especially rare, with only a small number of cases reported in the literature. Herein, we describe a case of an 86-year-old woman with a history of RCC treated by radical nephrectomy 13 years previously. The patient presented with duodenal obstruction and anemia from a solitary duodenal mass invading into the pancreas and was treated via classic pancreaticoduodenectomy. Preoperative imaging and intra-operative assessment showed no evidence of other disease. Pathology confirmed metastatic RCC without …

Illusory Predictors: Generalizability Of Findings In Cocaine Treatment Retention Research, Joy M Schmitz

Faculty, Staff and Student Publications

Treatment retention is of paramount importance in cocaine treatment research as treatment completion rates are often 50% or less. Failure to retain cocaine patients in treatment has both significant research and clinical implications. In this paper we qualitatively and quantitatively demonstrate the inconsistency found across analyses of retention predictors in order to highlight the problem. First, a qualitative review of the published literature was undertaken to identify the frequency of predictors studied and their relations to treatment retention. Second, an empirical demonstration of predictor stability was conducted by testing a common set of variables across three similar 12-week cocaine clinical …

Neurogranin Controls The Spatiotemporal Pattern Of Postsynaptic Ca2+/Cam Signaling

Faculty, Staff and Student Publications

Neurogranin (Ng) is a postsynaptic IQ-motif containing protein that accelerates Ca(2+) dissociation from calmodulin (CaM), a key regulator of long-term potentiation and long-term depression in CA1 pyramidal neurons. The exact physiological role of Ng, however, remains controversial. Two genetic knockout studies of Ng showed opposite outcomes in terms of the induction of synaptic plasticity. To understand its function, we test the hypothesis that Ng could regulate the spatial range of action of Ca(2+)/CaM based on its ability to accelerate the dissociation of Ca(2+) from CaM. Using a mathematical model constructed on the known biochemistry of Ng, we calculate the cycle …

Effect Of Endothelin 1 Genotype On Blood Pressure Is Dependent On Physical Activity Or Fitness Levels, Tuomo Rankinen, Timothy S. Church, Treva Rice, Nathan Markward, Arthur S. Leon, Dabeeru C. Rao, James S. Skinner, Steven N. Blair, Claude Bouchard

Faculty Publications

Contributions of the DNA sequence variation at the endothelin 1 locus to the risk of hypertension and to endurance training-induced changes in blood pressure were investigated in the Aerobics Center Longitudinal Study and the Health, Risk Factors, Exercise Training and Genetics Family Study cohorts. We identified 586 normotensive control subjects and 607 incident hypertensive case subjects from the Aerobics Center Longitudinal Study cohort (all whites) who were normotensive and healthy at their first clinical visit. The case subjects were diagnosed with hypertension during an average follow-up of 9.5 years, whereas the control subjects remained normotensive. The allele and genotype frequencies …

Objectively Assessed Associations Between Physical Activity And Body Composition In Middle-School Girls: The Trial Of Activity For Adolescent Girls, June Stevens, David M. Murray, Chris C. Baggett, John P. Elder, Timothy G. Lohman, Leslie A. Lytle, Russell R. Pate, Charlotte A. Pratt, Margarita S. Treuth, Larry S. Webber, Deborah Rohm Young

Faculty Publications

Declining levels of physical activity probably contribute to the increasing prevalence of overweight in US youth. In this study, the authors examined cross-sectional and longitudinal associations between physical activity and body composition in sixth- and eighth-grade girls. In 2003, girls were recruited from six US states as part of the Trial of Activity for Adolescent Girls. Physical activity was measured using 6 days of accelerometry, and percentage of body fat was calculated using an age- and ethnicity-specific prediction equation. Sixth-grade girls with an average of 12.8 minutes of moderate-to-vigorous physical activity (MVPA) per day (15th percentile) were 2.3 times (95% …

Moment Analysis Of Near-Equilibrium Binding Interactions During Electrophoresis, Yousef Daneshbod, James D. Sterling, Ali Nadim

Business and Information Technology Faculty Research & Creative Works

The electrophoretic transport of three chemically reacting species, two of which can bind reversibly to form the third, is analyzed mathematically. The species are assumed to move horizontally through a long channel with different electrophoretic mobilities and diffusion coefficients. By considering small perturbations of the system about equilibrium or when one of the two binding species is much more abundant than the other, the governing advection-reaction- diffusion equations can be linearized and studied via the method of moments. The result is a set of coupled ordinary differential equations for the moments that can be solved analytically. Analysis of the long-time …

Effects Of Delayed Auditory Feedback On The Bereitschaftspotential, Jennifer L. Johnson

Theses and Dissertations

This study examined the brain electrical activity of normal speakers in a non-delayed auditory feedback (DAF) condition and when experiencing DAF to determine the effect DAF would have on the Bereitschaftspotential (BP). The BP reflects the preparatory state of a person prior to motor execution of an act and can be observed 1500 to 500 ms prior to voluntary movement. The participants in the study included 10 adults with normal speech. Each read a series of 30 sentences, both without DAF and with DAF, while the BP was measured. Results indicate that the BP is present across the scalp in …

Split-Half Reliability Of Mlu And Mlu2 In Two Methods Of Utterance Segmentation, Alyse Diana Kemeny

Theses and Dissertations

Concerns regarding Mean Length of Utterance (MLU) has led to adaptations of this method of analysis. A recent study by Johnston (2001) introduced an alternative to MLU called MLU2. The current study investigates the split-half reliability of MLU and MLU2 as well as another alternative, Median Length of Utterance (Med-LU). Split-half reliability was found for these methods when segmented into Phonological and Communication Units. Split-half reliability of MLU2 was generally higher than that of MLU, and both were higher than Med-LU. The study suggests that MLU2 may also be a valuable tool for clinicians in analyzing child language.

Psychometrically Equivalent Cantonese Bisyllabic Word Recognition Materials Spoken By Male And Female Talkers, Brooke Kristin Conklin

Theses and Dissertations

The purpose of this study was to create psychometrically equivalent word lists in the language of Cantonese for word recognition testing. Frequently used bisyllabic Cantonese words were recorded by a native female and male talker. The word lists were evaluated by administering the word recognition lists to 20 native speakers of Cantonese with normal hearing. Each list was presented at 10 different intensity levels ranging from -5 to 40 dB HL in 5 dB increments. Logistic regression was used to determine the words with the steepest logistic regression slopes. The 200 words with the steepest slopes were then formulated into …

Wingless Activity In The Precursor Cells Specifies Neuronal Migratory Behavior In The Drosophila Nerve Cord

Faculty, Staff and Student Publications

Neurons and their precursor cells are formed in different regions within the developing CNS, but they migrate and occupy very specific sites in the mature CNS. The ultimate position of neurons is crucial for establishing proper synaptic connectivity in the brain. In Drosophila, despite its extensive use as a model system to study neurogenesis, we know almost nothing about neuronal migration or its regulation. In this paper, I show that one of the most studied neuronal pairs in the Drosophila nerve cord, RP2/sib, has a complicated migratory route. Based on my studies on Wingless (Wg) signaling, I report that the …

Allelic Heterogeneity At The Equine Kit Locus In Dominant White (W) Horses, Bianca Haase, Samantha A. Brooks, Angela Schlumbaum, Pedro J. Azor, Ernest Bailey, Ferial Alaeddine, Meike Mevissen, Dominik Burger, Pierre-André Poncet, Stefan Rieder, Tosso Leeb

Veterinary Science Faculty Publications

White coat color has been a highly valued trait in horses for at least 2,000 years. Dominant white (W) is one of several known depigmentation phenotypes in horses. It shows considerable phenotypic variation, ranging from approximately 50% depigmented areas up to a completely white coat. In the horse, the four depigmentation phenotypes roan, sabino, tobiano, and dominant white were independently mapped to a chromosomal region on ECA 3 harboring the KIT gene. KIT plays an important role in melanoblast survival during embryonic development. We determined the sequence and genomic organization of the approximately 82 kb equine KIT gene. A mutation …

Ua12/2/1 College Heights Herald, Vol. 83, No. 20, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

Ada News - 11/05/2007, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Understanding Barriers For Adherence To Follow-Up Care For Abnormal Pap Tests, Katherine S. Eggleston, Ann L. Coker, Irene Prabhu Das, Suzanne T. Cordray, Kathryn J. Luchok

CRVAW Faculty Journal Articles

Objective: Approximately 4000 women annually will die from preventable and treatable cervical cancer. Failure to adhere to follow-up recommendations after an abnormal Pap test can lead to development of cervical cancer. This paper summarizes the body of literature on adherence to follow-up after an abnormal Pap test in order to facilitate development of interventions

to decrease morbidity and mortality due to cervical cancer.

Methods: We conducted a comprehensive search of published literature addressing risk factors for adherence or interventions to improve adherence following an abnormal Pap test as the outcome. We included peer-reviewed original research conducted in the …

2007 Scholars And Artists Bibliography, Michael Schwartz Library, Cleveland State University, Friends Of The Michael Schwartz Library, Joanne E. Goodell Ph.D.

Scholars and Artists Bibliographies

This bibliography was created for the annual Friends of the Michael Schwartz Library Scholars and Artists Reception, recognizing scholarly and creative achievements of Cleveland State University faculty, staff and emeriti. Dr. Joanne Goodell was the guest speaker.

Download Full Pdf Issue Of Thomas Jefferson University Mph Public Health Link Newsletter, Vol. 3, Iss. 9, November/December 2007

Public Health Link

This issue includes: Jefferson’s MPH Program Active at the American Public Health Association (APHA) Meeting in Washington, D.C., an article written by Dr. Plumb "Homelessness—Care, Prevention and Public Policy", announcing new thesis presenters, Jefferson MPH Program Director, Dr. Simmons, Elected President of the Society for Public Health Education (SOPHE), announcing the New MPH Program Coordinator, and the First MPH Faculty and Community Advisory Board Dinner.

Oncolog, Volume 52, Number 11, November 2007, Diane Witter, Karen Stuyck, Garth Powis Dphil

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Outsmarting Brain Cancer
• Protecting the Heart
• House Call: Recognize the Signs of Ovarian Cancer
• DiaLog: Advancing Drug Design in Academia, by Garth Powis, DPhil, Director, Center for Targeted Therapy, Chair, Department of Experimental Therapeutics

The Acquisition Of Two Phonetic Cues To Word Boundaries, Melissa A. Redford, Christina E. Gildersleeve-Neumann

Speech and Hearing Sciences Faculty Publications and Presentations

The study evaluated whether durational and allophonic cues to word boundaries are intrinsic to syllable production, and so acquired with syllable structure, or whether they are suprasyllabic, and so acquired in phrasal contexts. Twenty preschool children (aged 3 ; 6 and 4 ; 6) produced: (1) single words with simple and complex onsets (e.g. "nail" vs. "snail"); and (2) two-word phrases with intervocalic consonant sequences and varying boundary locations (e.g. "this nail" vs. "bitty snail"). Comparisons between child and adult control productions showed that the durational juncture cue was emergent in the four-year-olds' productions of two-word phrases, but absent elsewhere. …

The Activity Of Azithromycin Against Leishmania (Viannia) Braziliensis And Leishmania (Leishmania) Amazonensis In The Golden Hamster Model., Angel Sinagra, Concepción Luna, David Abraham, Maria Del Carmen Iannella, Adelina Riarte, Alejandro J. Krolewiecki

Department of Microbiology and Immunology Faculty Papers

New therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania (Leishmania) major has been previously demonstrated. Different responses among species of Leishmania make species-specific drug screening necessary. The activity of azithromycin against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis was evaluated in golden hamsters infected through footpad injections of metacyclic promastigotes, and compared with untreated controls and animals treated with meglumine antimoniate. Footpad thickness, lesion cultures and dissemination sites were analyzed. Treatment of golden hamsters with oral azithromycin at 450mg/kg had no activity against infections with Leishmania (Leishmania) amazonensis. For infections due to Leishmania (Viannia) braziliensis, …

Audit Of An Acute Pain Service In A Tertiary Care Hospital In A Developing Country, Muhammad Qamarul Hoda, Mohammad Hamid, Fauzia Anis Khan

Department of Anaesthesia

The first anaesthesia based acute pain service (APS) was introduced in Pakistan at the Aga Khan University Hospital in July 2001, with the aim of patient safety and satisfaction. The American Society of Anesthesiologist task force guidelines were used for the introduction of APS. APS has managed 6810 patients during four and half years period. Common analgesic techniques used, were intravenous infusion (50%), patient controlled intravenous analgesia (18%) and epidural infusions (30%). Common reported side effects were nausea and vomiting with intravenous infusion (10%) and PCIA (10%) while motor block was noticed with epidural infusion (29%). This article aims to …

Human Tob, An Antiproliferative Transcription Factor, Is A Poly(A)-Binding Protein-Dependent Positive Regulator Of Cytoplasmic Mrna Deadenylation, Chyi-Ying A Chen, Ann-Bin Shyu

Faculty, Staff and Student Publications

In mammalian cells, mRNA decay begins with deadenylation, which involves two consecutive phases mediated by the PAN2-PAN3 and the CCR4-CAF1 complexes, respectively. The regulation of the critical deadenylation step and its relationship with RNA-processing bodies (P-bodies), which are thought to be a site where poly(A)-shortened mRNAs get degraded, are poorly understood. Using the Tet-Off transcriptional pulsing approach to investigate mRNA decay in mouse NIH 3T3 fibroblasts, we found that TOB, an antiproliferative transcription factor, enhances mRNA deadenylation in vivo. Results from glutathione S-transferase pull-down and coimmunoprecipitation experiments indicate that TOB can simultaneously interact with the poly(A) nuclease complex CCR4-CAF1 and …

The Resurgence Of The Adora2b Receptor As An Immunotherapeutic Target In Pancreatic Cancer

Faculty, Staff and Student Publications

Subfields of the hippocampus display differential dynamics in processing a spatial environment, especially when changes are introduced to the environment. Specifically, when familiar cues in the environment are spatially rearranged, place cells in the CA3 subfield tend to rotate with a particular set of cues (e.g., proximal cues), maintaining a coherent spatial representation. Place cells in CA1, in contrast, display discordant behaviors (e.g., rotating with different sets of cues or remapping) in the same condition. In addition, on average, CA3 place cells shift their firing locations (measured by the center of mass, or COM) backward over time when the animal …

Is A 3-Mm Intrafractional Margin Sufficient For Daily Image-Guided Intensity-Modulated Radiation Therapy Of Prostate Cancer?, Adam D Melancon, Jennifer C O'Daniel, Lifei Zhang, Rajat J Kudchadker, Deborah A Kuban, Rex M Cheung, Susan L Tucker, Wayne D Newhauser, Radhe Mohan, Lei Dong

Faculty, Staff and Student Publications

PURPOSE: To determine whether a 3-mm isotropic target margin adequately covers the prostate and seminal vesicles (SVs) during administration of an intensity-modulated radiation therapy (IMRT) treatment fraction, assuming that daily image-guided setup is performed just before each fraction.

MATERIALS AND METHODS: In-room computed tomographic (CT) scans were acquired immediately before and after a daily treatment fraction in 46 patients with prostate cancer. An eight-field IMRT plan was designed using the pre-fraction CT with a 3-mm margin and subsequently recalculated on the post-fraction CT. For convenience of comparison, dose plans were scaled to full course of treatment (75.6 Gy). Dose coverage …

The Routine Use Of Preoperative Non-Contrast Chest Computerized Tomography And Carotid Arteries Doppler Prior To Cardiac Surgery, Liming Li

Faculty, Staff and Student Publications

Yeast prions are a group of non-Mendelian genetic elements transmitted as altered and self-propagating conformations. Extensive studies in the last decade have provided valuable information on the mechanisms responsible for yeast prion propagation. How yeast prions are formed de novo and what cellular factors are required for determining prion "strains" or variants--a single polypeptide capable of existing in multiple conformations to result in distinct heritable phenotypes--continue to defy our understanding. We report here that Sse1, the yeast ortholog of the mammalian heat-shock protein 110 (Hsp110) and a nucleotide exchange factor for Hsp70 proteins, plays an important role in regulating [PSI+] …

Relative Contributions Of Enterococcus Faecalis Og1rf Sortase-Encoding Genes, Srta And Bps (Srtc), To Biofilm Formation And A Murine Model Of Urinary Tract Infection

Faculty, Staff and Student Publications

Deletion mutants of the two sortase genes of Enterococcus faecalis OG1RF were constructed. srtC (renamed here bps for biofilm and pilus-associated sortase) was previously shown to be necessary for the production of Ebp pili and important for biofilm formation and endocarditis. Here, we report that a srtA deletion mutant showed a small (5%) yet significant (P = 0.037) reduction in biofilm relative to OG1RF, while a DeltasrtA Deltabps double mutant showed a much greater reduction (74% versus OG1RF and 44% versus the Deltabps mutant). In a murine urinary tract infection (UTI), the 50% infective doses of both the DeltasrtA Deltabps …