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Full-Text Articles in Entire DC Network
Emotion Regulation Strategies And Perceived Emotional Intelligence: The Effect Of Age., Iwanna Sepiadou
Emotion Regulation Strategies And Perceived Emotional Intelligence: The Effect Of Age., Iwanna Sepiadou
Adultspan Journal
The aim of this study was to investigate the relationship between perceived emotional intelligence and the reported use of cognitive reappraisal and expressive suppression. We also investigated the possible effects of age on the aforementioned variables. The total sample consisted of 379 people (158 men, 220 women, 1 unreported). Across participants, 273 were young (20-39 years old) and 106 were middle-aged (40-65 years old). We found statistically significant positive correlations between the dimensions of perceived emotional intelligence and the reported use of cognitive reappraisal and negative primarily correlations between the dimensions of perceived emotional intelligence and the reported use of …
Development Of Long-Acting Antiviral And Antimicrobial Prodrug Nanoformulations, Srijanee Das
Development Of Long-Acting Antiviral And Antimicrobial Prodrug Nanoformulations, Srijanee Das
Theses & Dissertations
Over the past decade, the global burden of infectious diseases has increased substantively, underscoring the need for more effective treatment strategies. However, the discovery and development of new drugs with desirable safety, pharmacokinetics, and efficacy is a time consuming and costly process with great uncertainty around success rate. As an alternative to new drug development, prodrugs and novel drug delivery systems have increasingly been explored. Both serve to overcome the drug development challenges. Such drug formulations that permit extended dosing intervals of potent native drugs serve multiple purposes by promoting patient adherence to in improving treatment outcomes. This is especially …
Molding The Self: Understanding Adoptees' Identity Formation, A Literature Review, Carolyn Brazil
Molding The Self: Understanding Adoptees' Identity Formation, A Literature Review, Carolyn Brazil
Expressive Therapies Capstone Theses
The topic under investigation focuses on the complex process of identity formation in adoptees, particularly those in transracial and international adoption scenarios. Grounding this topic in theory, the author draws from psychological and sociological perspectives. The literature illustrates key factors in adoptees' identity formation, and it emphasizes the importance of family involvement and cultural connections in integrating identities, as well as the role of cultural ties in understanding racial identities. The conclusion from this study reveals the complexities and clinical considerations of adoptee identity formation, showing their challenges in combining birth and adoptive cultures. It underscores the value of art …
Increasing Motivation In Stem Education: A Self-Talk Classroom Intervention, Tiffany L. Copeland, Richard Allen, Sofia Pham, Kristin Gagnier
Increasing Motivation In Stem Education: A Self-Talk Classroom Intervention, Tiffany L. Copeland, Richard Allen, Sofia Pham, Kristin Gagnier
Research Day
INTRODUCTION: This study examines a social-emotional learning intervention that teaches positive self-talk to high school students from underrepresented minority groups in science, technology, engineering, and math (STEM). The setting of this study is a place-based program that immerses students in hands-on STEM activities while located in Philadelphia’s life science hub. Before taking a science assessment, students will learn to say self-talk statements such as “I will give my best effort” and “I can achieve a high score.”
METHODS: This mixed method quasi-experimental design compares pre- and post-program data using an ANOVA. Student science performance will be measured using a probe …
Protocols For Enhancing The Role And Value Of Spiritual Care Resources In The Metropolitan Nashville Police Department, Garrett Harper
Protocols For Enhancing The Role And Value Of Spiritual Care Resources In The Metropolitan Nashville Police Department, Garrett Harper
Doctor of Ministry Theses and Dissertations
This thesis addresses the assessment of innovative practices in police chaplaincy. The purpose of the project intervention is to develop protocols that can guide police chaplains through an assessment process. The intervention relies on practical theology as exemplified through the ministry of chaplaincy. This ministry comprises police chaplains offering spiritual comfort to persons encountering critical incidents involving violence, accident, or other trauma-intensive events and situations. Adoption of innovations can allow police chaplains to be more effective in fulfilling many outward-focused tasks such as delivery of death notifications. I conclude that: (1) police chaplaincy is amenable to use of protocols to …
Investigating Effects Of Co-Culturing With Vibrio Fischeri On Secondary Metabolite Production Of Hawaiian Bobtail Squid Symbionts, Mariam A. Zedan
Investigating Effects Of Co-Culturing With Vibrio Fischeri On Secondary Metabolite Production Of Hawaiian Bobtail Squid Symbionts, Mariam A. Zedan
Honors Scholar Theses
Microbes are a fruitful source of natural product drug discovery since many of their secondary metabolites show defensive activity and have unique structures. However, extracting and elucidating the structure of those compounds can be challenging in vitro due to particular environmental and nutritional requirements of some bacteria. Those requirements may include proximity to other organisms that the microbes have symbiotic relationships with. Under those conditions, the organism may activate silent biosynthetic gene clusters (BGCs) responsible for production of certain secondary metabolites not typically expressed otherwise. One method of BGC induction is co-culturing with other microbes since this mimics the natural …
Effect Of Asynchronous Virtual Interviews On Ethnic Minority Matriculation Into A Doctor Of Physical Therapy Program, Conner Clark, Nanea Lagasca, Gladys Miller, Jasmine Puspos
Effect Of Asynchronous Virtual Interviews On Ethnic Minority Matriculation Into A Doctor Of Physical Therapy Program, Conner Clark, Nanea Lagasca, Gladys Miller, Jasmine Puspos
UNLV Theses, Dissertations, Professional Papers, and Capstones
Purpose/Methods: This study examines the impact of the use of asynchronous virtual interviews (AVIs) in the admissions process of the Doctor of Physical Therapy (DPT) program at the University of Nevada, Las Vegas (UNLV). This research aims to examine racial and ethnic subgroup differences in AVI scores, evaluate the influence of AVIs on applicant scores in the admissions process, and assess the AVI inter-rater reliability among faculty evaluators using data from the 2019-2022 admissions cycles.
Results: Significant differences were found in AVI scores among racial and ethnic groups, with Black applicants scoring highest and Asian applicants scoring lowest. Additionally, inclusion …
Amphipathic Hybrid Cyclic-Linear Peptides As A Drug Delivery System, Jonathan Moreno
Amphipathic Hybrid Cyclic-Linear Peptides As A Drug Delivery System, Jonathan Moreno
Pharmaceutical Sciences (PhD) Dissertations
Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System by Jonathan A. Moreno Peptides
[RW]4 and [R5W4] have been previously identified as molecular transporter Cell Penetrating Peptide (CPP) and antimicrobial agents, respectively. These peptides consisted of alternating and non-alternating arginine (R) as positively charged residues and tryptophan (W) as hydrophobic residues. Herein we report the synthesis of two hybrid amphipathic cyclic-linear cell-penetrating peptides [RW]4K-AH135 (1) and [R5W4]K-AH135 (2) composed of [RW]4 and [R5W4] and a linear peptide AH-135 (Ac)NH-RWLRRWLRWWRR-COOH. The …
Health Literacy And Cervical Cancer Prevention Behaviors Among Hispanic Women In Idaho, Delmy Flores
Health Literacy And Cervical Cancer Prevention Behaviors Among Hispanic Women In Idaho, Delmy Flores
Boise State University Theses and Dissertations
Purpose
Explore relationships between health literacy, culture, accessibility and utilization of health care services, patient/provider communication, and “self-care” factors that influence cervical cancer prevention behaviors (i.e., HPV vaccination and screening) among Hispanic women between 40-65 years old living in Idaho. These factors were explored in relation to how participants obtained, processed, and understood information about cervical cancer and its prevention. Understanding these factors and potential relationships to health literacy is pivotal for tailoring effective communication strategies and interventions within this specific demographic.
Methods
Recruited (n=15) Hispanic women living in Idaho, between 40-65 years old, to participate in a semi-structured qualitative …
The Role Of Cosmopolitan Orientation In Covid-19-Related Attitudes: Perceived Threats And Opportunities, Vaccination Willingness, And Support For Collective Containment Efforts, Angela K. Y. Leung, Brandon Koh, Verity Yu Qing Lua, James H. Liu, Sarah Y. Choi, I-Ching Lee, Michelle Lee, Mei-Hua Lin, Darrin Hodgetts, Sylvia X. Chen
The Role Of Cosmopolitan Orientation In Covid-19-Related Attitudes: Perceived Threats And Opportunities, Vaccination Willingness, And Support For Collective Containment Efforts, Angela K. Y. Leung, Brandon Koh, Verity Yu Qing Lua, James H. Liu, Sarah Y. Choi, I-Ching Lee, Michelle Lee, Mei-Hua Lin, Darrin Hodgetts, Sylvia X. Chen
Research Collection School of Social Sciences
Cosmopolitan individuals identify themselves as "citizens of the world." In the present research, we tested the idea that endorsing a cosmopolitan orientation (CO) is adaptive in the COVID-19 crisis. Cosmopolitan individuals more readily transcend national parochialism, show greater concern for all humanity, and prioritize collective interests. In a two-wave multi-region investigation with six samples from China, Hong Kong, Taiwan, Malaysia, Singapore, and the U.S., we first established longitudinal and cross-cultural measurement invariance of the CO scale. Next, we found that people with a higher CO tended to perceive over time a greater threat posed by COVID-19, take more safety measures, …
Examining The Effects Of A Week-Long Social Media Abstinence Intervention, Iweek, On General Well-Being, Mental Health, And Body Image Concerns In Latina College Students, Roberto Sagaribay
Examining The Effects Of A Week-Long Social Media Abstinence Intervention, Iweek, On General Well-Being, Mental Health, And Body Image Concerns In Latina College Students, Roberto Sagaribay
Open Access Theses & Dissertations
Latina college students, on average, spend approximately 30 hours per week on social media, highlighting the pervasive influence of social media on their lives. While social media can facilitate interpersonal relationships, its impact on mental and physical health is evident in the literature. Problematic social media use has been associated with increased rates of depression, anxiety, and decreased life satisfaction. Additionally, exposure to idealized images on social media platforms often leads to lower body satisfaction, particularly among women. Social media may also influence eating behaviors through the abundance of food advertisements and contribute to sedentary behavior, as individuals spend significant …
Goal Commitment As Mediator Of Relationship Between Emotional Intelligence And Career Decision Difficulties Among Vocational High School Students, Thalia Zamira, Puji Lestari Suharso
Goal Commitment As Mediator Of Relationship Between Emotional Intelligence And Career Decision Difficulties Among Vocational High School Students, Thalia Zamira, Puji Lestari Suharso
Jurnal Kajian Bimbingan dan Konseling
Vocational high school students were provided with a curriculum designed to facilitate their transition into the workforce. Elicitation studies have indicated that vocational high school students experience difficulties in making career decisions. The internship program is designed to enhance students' emotional intelligence and goal commitment, thereby preventing career decision-making difficulties. This research aims to investigate the mediating effect of goal commitment in the relationship between emotional intelligence and career decision-making difficulties. This quantitative correlational research was conducted in a vocational high school in Bogor with a total of 173 participants using a self-report questionnaire of CDDQ, TEIQue-SF, and HWK Scale. …
Effectiveness Of Group Guidance With Group Investigation Learning Model To Develop Students' Assertiveness, Muya Barida, Gefira Nurchairunnissa, Wahyu Nanda Eka Saputra, Aprilia Setyowati, Ediyanto Ediyanto, Adi Atmoko
Effectiveness Of Group Guidance With Group Investigation Learning Model To Develop Students' Assertiveness, Muya Barida, Gefira Nurchairunnissa, Wahyu Nanda Eka Saputra, Aprilia Setyowati, Ediyanto Ediyanto, Adi Atmoko
Jurnal Kajian Bimbingan dan Konseling
Adolescents require assertiveness in socializing and interacting with their social environment in order to be able to express themselves well. However, there are still many adolescents who have not been able to express their thoughts, feelings, and hopes. This research aims to test the efficacy of group guidance services using the group investigation learning model to increase adolescent assertiveness. This research uses a one-group pretest-posttest research design to achieve the research objectives. The research subjects were six students at State Junior High School. The techniques and instruments used for data collection were an assertiveness scale. The assertiveness scale was tested …
The Alexander Technique Applied To Dance And The Choreographic Process: Freeing Physical Expression From Trauma-Based Tension, Julia Johnston
The Alexander Technique Applied To Dance And The Choreographic Process: Freeing Physical Expression From Trauma-Based Tension, Julia Johnston
Senior Honors Theses
Ballet, contemporary, and modern dancers have expressed incurring trauma during their training and professional dance experiences; in a 2020 survey, 41% of professional dancers and 30% of ballet students reported experiencing or witnessing sexually inappropriate behavior in their respective workplaces and schools (DDP). This is just one example of a potential source of trauma for dancers. The physiological effects of trauma cause physical effects, creating tension in a dancer’s body. Dance relies on physical expression, the expression of thought and feeling through movement, to connect with the audience. Trauma-based tension inhibits a dancer’s range of physical expression and connection to …
N-Glycoproteomic Analyses Of Human Intestinal Enteroids, Varying In Histo-Blood Group Geno- And Phenotypes, Reveal A Wide Repertoire Of Fucosylated Glycoproteins, Jonas Nilsson, Inga Rimkute, Carina Sihlbom, Victoria R Tenge, Shih-Ching Lin, Robert L Atmar, Mary K Estes, Göran Larson
N-Glycoproteomic Analyses Of Human Intestinal Enteroids, Varying In Histo-Blood Group Geno- And Phenotypes, Reveal A Wide Repertoire Of Fucosylated Glycoproteins, Jonas Nilsson, Inga Rimkute, Carina Sihlbom, Victoria R Tenge, Shih-Ching Lin, Robert L Atmar, Mary K Estes, Göran Larson
Faculty, Staff and Students Publications
Human noroviruses, globally the main cause of viral gastroenteritis, show strain specific affinity for histo-blood group antigens (HBGA) and can successfully be propagated ex vivo in human intestinal enteroids (HIEs). HIEs established from jejunal stem cells of individuals with different ABO, Lewis and secretor geno- and phenotypes, show varying susceptibility to such infections. Using bottom-up glycoproteomic approaches we have defined and compared the N-linked glycans of glycoproteins of seven jejunal HIEs. Membrane proteins were extracted, trypsin digested, and glycopeptides enriched by hydrophilic interaction liquid chromatography and analyzed by nanoLC-MS/MS. The Byonic software was used for glycopeptide identification followed by hands-on …
Emerging Therapies For Glioblastoma, Stella Aime Rios, Stephanie Oyervides, David Uribe, Angelica Maree Reyes, Victor Fanniel, Jonathan Vazquez, Megan Keniry
Emerging Therapies For Glioblastoma, Stella Aime Rios, Stephanie Oyervides, David Uribe, Angelica Maree Reyes, Victor Fanniel, Jonathan Vazquez, Megan Keniry
School of Integrative Biological & Chemical Sciences Faculty Publications
Glioblastoma is most commonly a primary brain tumor and the utmost malignant one, with a survival rate of approximately 12–18 months. Glioblastoma is highly heterogeneous, demonstrating that different types of cells from the same tumor can manifest distinct gene expression patterns and biological behaviors. Conventional therapies such as temozolomide, radiation, and surgery have limitations. As of now, there is no cure for glioblastoma. Alternative treatment methods to eradicate glioblastoma are discussed in this review, including targeted therapies to PI3K, NFKβ, JAK-STAT, CK2, WNT, NOTCH, Hedgehog, and TGFβ pathways. The highly novel application of oncolytic viruses and nanomaterials in combating glioblastoma …
Identifying And Referring Patients For Occupational Therapy Services In Developing Countries, Rachel Pudlik
Identifying And Referring Patients For Occupational Therapy Services In Developing Countries, Rachel Pudlik
MOT Student Capstones
Objective: Developing nations lack the resources and trained professionals on a local level to provide healthcare services. Medical mission organizations host trips in developing nations to provide short term medical care to bridge the gap in services. However, Occupational Therapy (OT) services are underutilized within these organizations. This capstone project explores the expansion of OT services within one medical mission organization, specifically with their school based population, by using a sensory based lens to identify students that would benefit from OT services. Methods: The methodology portion of this project includes reviewing evidence based research articles. conducting needs assessment. completion of …
Beyond The Looking Glass: Dreams And Somnial States And Spaces In Nineteenth-Century British Literature, Anne N. Nagel
Beyond The Looking Glass: Dreams And Somnial States And Spaces In Nineteenth-Century British Literature, Anne N. Nagel
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Poised between a waning magico-theological tradition of symbolic dream interpretation and the rising influence of scientific dream theories, which equated dreaming with disorder, the dream occupied a unique space in nineteenth-century Great Britain. Dreams were coming untethered from signification, as natural philosophers deemed their content indecipherable and chaotic. Yet vestiges of early modern beliefs could still lend supernatural power and polyphony to dreams.
This was not simply a matter of making a binary choice between two ways of thinking about dreams but instead a site of collisions and coalescences. I contend that the ways in which dreams were conceptualized in …
Navigating Intersectional Identities: Mental Health Challenges And Accessibility To Mental Health Care Among Sub-Saharan Migrant Women In Morocco, Soraya Babahaji
Navigating Intersectional Identities: Mental Health Challenges And Accessibility To Mental Health Care Among Sub-Saharan Migrant Women In Morocco, Soraya Babahaji
Independent Study Project (ISP) Collection
Since the beginning of the 21st century, as Morocco transitions from solely being a transit point to Europe to becoming a destination country for Sub-Saharan migrants, policies have been implemented to improve migrant integration. Morocco launched the National Strategy on Immigration and Asylum in 2015 which strives to ensure accessibility to essential services for migrants, such as education, healthcare, and integration into the workforce. In addition, through the 2013 New Migration Policy framework, King Mohammed VI aims to “include avenues for regularization” to help migrants integrate into Moroccan society.
This paper addresses how intersecting factors of identity can lead to …
The Role Of Epigenetic Mechanisms In The Long-Term Effects Of Early-Life Adversity And Mother-Infant Relationship On Physiology And Behavior Of Offspring In Laboratory Rats And Mice, Olga V Burenkova, Elena L Grigorenko
The Role Of Epigenetic Mechanisms In The Long-Term Effects Of Early-Life Adversity And Mother-Infant Relationship On Physiology And Behavior Of Offspring In Laboratory Rats And Mice, Olga V Burenkova, Elena L Grigorenko
Faculty, Staff and Students Publications
Maternal care during the early postnatal period of altricial mammals is a key factor in the survival and adaptation of offspring to environmental conditions. Natural variations in maternal care and experimental manipulations with maternal-child relationships modeling early-life adversity (ELA) in laboratory rats and mice have a strong long-term influence on the physiology and behavior of offspring in rats and mice. This literature review is devoted to the latest research on the role of epigenetic mechanisms in these effects of ELA and mother-infant relationship, with a focus on the regulation of hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor. An important part of …
Coping Strategies For Nurses’ Distress In Dealing With The Covid-19 Pandemic: A Scoping Review, Ika Nopa, L Meily Kurniawidjaja, Dadan Erwandi
Coping Strategies For Nurses’ Distress In Dealing With The Covid-19 Pandemic: A Scoping Review, Ika Nopa, L Meily Kurniawidjaja, Dadan Erwandi
Jurnal Keperawatan Indonesia
It is a well-known fact that the COVID-19 pandemic exacerbated the work stressors of nurses, which were already a problem previously, causing great distress. Hence, the need for effective coping strategies has been realized to prevent such distress, especially if a pandemic recurs. Determining how the types of coping strategies used by nurses impact their distress level in COVID-19 Pandemic. This review was conducted using the PRISMA Statement Recommendations Checklist and PRISMA—Extension for Scoping Reviews (PRISMA-SCR). The databases used were Willey Library, Science Direct, SCOPUS, and Springer Link for the literature search. Nurse and (“coping type” or “brief cope”) and …
Best Integrated Writing Spring 2024 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Kristie Mckiernan, Tracy Smith
Best Integrated Writing Spring 2024 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Kristie Mckiernan, Tracy Smith
Best Integrated Writing
Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University. This is the first issue after a 5 year hiatus.
Identifying Potential Dietary Treatments For Inherited Metabolic Disorders Using Drosophila Nutrigenomics, Felipe Martelli, Jiayi Lin, Sarah Mele, Wendy Imlach, Oguz Kanca, Christopher K Barlow, Jefferson Paril, Ralf B Schittenhelm, John Christodoulou, Hugo J Bellen, Matthew D W Piper, Travis K Johnson
Identifying Potential Dietary Treatments For Inherited Metabolic Disorders Using Drosophila Nutrigenomics, Felipe Martelli, Jiayi Lin, Sarah Mele, Wendy Imlach, Oguz Kanca, Christopher K Barlow, Jefferson Paril, Ralf B Schittenhelm, John Christodoulou, Hugo J Bellen, Matthew D W Piper, Travis K Johnson
Faculty, Staff and Students Publications
Inherited metabolic disorders are a group of genetic conditions that can cause severe neurological impairment and child mortality. Uniquely, these disorders respond to dietary treatment; however, this option remains largely unexplored because of low disorder prevalence and the lack of a suitable paradigm for testing diets. Here, we screened 35 Drosophila amino acid disorder models for disease-diet interactions and found 26 with diet-altered development and/or survival. Using a targeted multi-nutrient array, we examine the interaction in a model of isolated sulfite oxidase deficiency, an infant-lethal disorder. We show that dietary cysteine depletion normalizes their metabolic profile and rescues development, neurophysiology, …
Establishment Of Murine Pregnancy Requires The Promyelocytic Leukemia Zinc Finger Transcription Factor, Lan Hai, Vineet K Maurya, Francesco J Demayo, John P Lydon
Establishment Of Murine Pregnancy Requires The Promyelocytic Leukemia Zinc Finger Transcription Factor, Lan Hai, Vineet K Maurya, Francesco J Demayo, John P Lydon
Faculty, Staff and Students Publications
Using an established human primary cell culture model, we previously demonstrated that the promyelocytic leukemia zinc finger (PLZF) transcription factor is a direct target of the progesterone receptor (PGR) and is essential for progestin-dependent decidualization of human endometrial stromal cells (HESCs). These in vitro findings were supported by immunohistochemical analysis of human endometrial tissue biopsies, which showed that the strongest immunoreactivity for endometrial PLZF is detected during the progesterone (P4)-dominant secretory phase of the menstrual cycle. While these human studies provided critical clinical support for the important role of PLZF in P4-dependent HESC decidualization, functional validation in vivo was not …
Abdominal Aortic Aneurysms And Platelets: Infiltration, Inflammation, And Elastin Disintegration, Bowen Li, Hong S. Lu, Alan Daugherty
Abdominal Aortic Aneurysms And Platelets: Infiltration, Inflammation, And Elastin Disintegration, Bowen Li, Hong S. Lu, Alan Daugherty
Saha Cardiovascular Research Center Faculty Publications
No abstract provided.
Granulocytic Myeloid-Derived Suppressor Cell Activity During Biofilm Infection Is Regulated By A Glycolysis/Hif1a Axis, Christopher M. Horn, Prabhakar Arumugam, Zachary Van Roy, Cortney E. Heim, Rachel W. Fallet, Blake P. Bertrand, Dhananjay Shinde, Vinai Chittezham Thomas, Svetlana Romanova, Tatiana K. Bronich, Curtis Hartman, Kevin Garvin, Tammy Kielian
Granulocytic Myeloid-Derived Suppressor Cell Activity During Biofilm Infection Is Regulated By A Glycolysis/Hif1a Axis, Christopher M. Horn, Prabhakar Arumugam, Zachary Van Roy, Cortney E. Heim, Rachel W. Fallet, Blake P. Bertrand, Dhananjay Shinde, Vinai Chittezham Thomas, Svetlana Romanova, Tatiana K. Bronich, Curtis Hartman, Kevin Garvin, Tammy Kielian
Journal Articles: Pathology and Microbiology
Staphylococcus aureus is a leading cause of biofilm-associated prosthetic joint infection (PJI). A primary contributor to infection chronicity is an expansion of granulocytic myeloid-derived suppressor cells (G-MDSCs), which are critical for orchestrating the antiinflammatory biofilm milieu. Single-cell sequencing and bioinformatic metabolic algorithms were used to explore the link between G-MDSC metabolism and S. aureus PJI outcome. Glycolysis and the hypoxia response through HIF1a were significantly enriched in G-MDSCs. Interfering with both pathways in vivo, using a 2-deoxyglucose nanopreparation and granulocyte-targeted Hif1a conditional KO mice, respectively, attenuated G-MDSC-mediated immunosuppression and reduced bacterial burden in a mouse model of S. aureus PJI. …
Elucidating The Role Of The Tumor Suppressor Gene Rna-Binding Motif 5 (Rbm5) In Models Of Traumatic Brain Injury, Kara L. Snyder
Elucidating The Role Of The Tumor Suppressor Gene Rna-Binding Motif 5 (Rbm5) In Models Of Traumatic Brain Injury, Kara L. Snyder
USF Tampa Graduate Theses and Dissertations
Traumatic brain injury (TBI) is a worldwide health burden that causes death and disability. Clinical management of TBI involves guideline-based protocols to limit secondary brain injury but there remains an unmet need for therapeutics to target neuroprotection and to improve cognitive outcomes in patients. This dissertation concerns the examination of RNA binding motif 5 (RBM5) as a potential therapeutic gene target to promote neuroprotection in models of TBI. RBM5 is a potent pro-death tumor suppressor gene in cancer. We hypothesized that it also promotes cell death in neurons in the brain and therefore its inhibition would decrease neuropathology following CNS …
Conceptualizing Care Partners' Burden, Stress, And Support For Reintegrating Veterans: A Mixed Methods Study, Nicholas A. Rattray, Mindy Flanagan, Allison Mann, Leah Danson, Ai-Nghia Do, Diana Natividad, Katrina Spontak, Gala True
Conceptualizing Care Partners' Burden, Stress, And Support For Reintegrating Veterans: A Mixed Methods Study, Nicholas A. Rattray, Mindy Flanagan, Allison Mann, Leah Danson, Ai-Nghia Do, Diana Natividad, Katrina Spontak, Gala True
School of Medicine Faculty Publications
BACKGROUND: People who support Veterans as they transition from their military service into civilian life may be at an increased risk of psychological distress. Existing studies focus primarily on paid family caregivers, but few studies include spouses and informal non-family "care partners." We sought to identify key challenges faced by care partners of Veterans with invisible injuries. METHODS: Semi-structured interviews were conducted with 36 individuals involved in supporting a recently separated US military Veteran enrolled in a 2-year longitudinal study. CPs completed validated measures on perceived stress, caregiving burden, quality of their relationship, life satisfaction, and flourishing. Independent -tests were …
Sionx Coating Regulates Mesenchymal Stem Cell Antioxidant Capacity Via Nuclear Erythroid Factor 2 Activity Under Toxic Oxidative Stress Conditions, Neelam Ahuja, Kamal Awad, Su Yang, He Dong, Antonios Mikos, Pranesh Aswath, Simon Young, Marco Brotto, Venu Varanasi
Sionx Coating Regulates Mesenchymal Stem Cell Antioxidant Capacity Via Nuclear Erythroid Factor 2 Activity Under Toxic Oxidative Stress Conditions, Neelam Ahuja, Kamal Awad, Su Yang, He Dong, Antonios Mikos, Pranesh Aswath, Simon Young, Marco Brotto, Venu Varanasi
Faculty, Staff and Student Publications
Healing in compromised and complicated bone defects is often prolonged and delayed due to the lack of bioactivity of the fixation device, secondary infections, and associated oxidative stress. Here, we propose amorphous silicon oxynitride (SiONx) as a coating for the fixation devices to improve both bioactivity and bacteriostatic activity and reduce oxidative stress. We aimed to study the effect of increasing the N/O ratio in the SiONx to fine-tune the cellular activity and the antioxidant effect via the NRF2 pathway under oxidative stress conditions. The in vitro studies involved using human mesenchymal stem cells (MSCs) to examine the effect of …
Tumor Treating Fields Increases Blood-Brain Barrier Permeability And Relative Cerebral Blood Volume In Patients With Glioblastoma, Michael Iv, Lewis Naya, Sajal Sanan, Samuel L Van Buskirk, Seema Nagpal, Reena P Thomas, Lawrence D Recht, Chirag B Patel
Tumor Treating Fields Increases Blood-Brain Barrier Permeability And Relative Cerebral Blood Volume In Patients With Glioblastoma, Michael Iv, Lewis Naya, Sajal Sanan, Samuel L Van Buskirk, Seema Nagpal, Reena P Thomas, Lawrence D Recht, Chirag B Patel
Faculty, Staff and Student Publications
BACKGROUND AND OBJECTIVE: 200 kHz tumor treating fields (TTFields) is clinically approved for newly-diagnosed glioblastoma (nGBM). Because its effects on conventional surveillance MRI brain scans are equivocal, we investigated its effects on perfusion MRI (pMRI) brain scans.
METHODS: Each patient underwent institutional standard pMRI: dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) pMRI at three time points: baseline, 2-, and 6-months on-adjuvant therapy. At each timepoint, the difference between T1 pre- versus post-contrast tumor volume (ΔT1) and these pMRI metrics were evaluated: normalized and standardized relative cerebral blood volume (nRCBV, sRCBV); fractional plasma volume (V
RESULTS: Among 13 pMRI datasets …