Digital Commons Network^™

An Inaugural Dissertation On The Properties Of The Apocynum Cannabinum, (Indian Hemp;) Submitted To The Trustees, President, And Medical Faculty Of Jefferson College., M. L. Knapp

Jefferson Medical College Theses

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No abstract provided.

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Human Complement Protein C8: The “Hole” Story, James M. Sodetz

Journal of the South Carolina Academy of Science

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No abstract provided.

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Efficacy And Safety Of A Novel Technique Using Endoscopic Ultrasound—Guided Fine-Needle Injection Of Botulinum Toxin And Balloon Dilation In Achalasia, Aqsa Kahn, Harishankar Gopakumar, Ricardo J. Marrero Torres, Ahmad Abulawi, Talia Malik, Dushyant Singh Dahiya, Mariajose Rojas Deleon, Amelia Roebuck, Neil Sharma

PCI Publications and Projects

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Background and Aims

Achalasia is an esophageal motility disorder characterized by the inability of the lower esophageal sphincter to relax. Endoscopic methods are currently the mainstay treatment of achalasia and include local administration of botulinum toxin (Botox; Allergan Aesthetics, Westport, County Mayo, Ireland), pneumatic dilation, and peroral endoscopic myotomy. Botox injections traditionally have been performed by standard endoscopy, which lacks precision requiring frequent interventions. Our study introduces a novel technique using endoscopic ultrasound—guided fine-needle injection of Botox combined with controlled radial expansion balloon dilation (EUS-BTID) for treating achalasia. We hypothesize that this combined approach will enhance the efficacy and offer …

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An Investigation In The Treatment Of Anisometropia With Orthokeratology Lenses, Cara Finn

Student Theses, Dissertations and Capstones

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Purpose: The purpose of this study is to evaluate the treatment and management of anisometropia with orthokeratology lenses compared to traditional spectacle lenses. The present study aimed to quantify the interocular difference in relative corneal refractive power shift and examine its association with the differential axial growth.

Methods: One hundred and two subjects between the ages 8 and 14 years old with over -0.50D of myopia and at least 1D of anisometropia were treated with either orthokeratology lenses or traditional single vision spectacle lenses. Baseline data of axial length, refraction, and corneal topography were taken at the initial visit and …

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Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

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Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …

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