Digital Commons Network^™

Complementary Vertebrate Wac Models Exhibit Phenotypes Relevant To Desanto-Shinawi Syndrome, Kang-Han Lee, Marwan Shinawi, Et Al.

2020-Current year OA Pubs

Monogenic syndromes are associated with neurodevelopmental changes that result in cognitive impairments and neurobehavioral phenotypes, including autism and seizures. Limited studies and resources are available to make meaningful headway into the underlying molecular mechanisms that result in these symptoms. One such example is DeSanto-Shinawi Syndrome (DESSH), a rare disorder caused by pathogenic variants in the

Assessment Of Timp1, Transgelin-2, And Procalcitonin As Protein Biomarkers For Diagnosis And Prognosis Of Bloodstream Infection In A Critically Ill Cohort, Sajal Tiwary, Caroline A O'Neil, Sydney Lawless, Olivia Arter, Meghan Brown, Brittany Roemmich, Carleigh Samuels, Jennie H Kwon, Christopher W Farnsworth

2020-Current year OA Pubs

BACKGROUND: Bloodstream infections (BSI) are a significant contributor to morbidity and mortality among hospitalized patients. Rapid diagnosis of BSI is critical for timely and appropriate clinical management, but current diagnostic strategies have a prolonged turnaround time or only identify select pathogens with minimal prognostic information.

METHODS: We examined serial serologic samples from 77 intensive care unit (ICU) patients at time points before, during, and after diagnosis of presumptive BSI to identify host-derived protein biomarkers associated with specific organisms and with clinical outcomes in BSI. ICU patients with and without BSI were included. Two candidate biomarkers, tissue metalloproteinase 1 (TIMP-1) and …

Benchmarking Institutional Support For Point-Of-Care Testing Programs: Scale, Staffing, And Operational Challenges, Min Yu, Nam K Tran, Julie L V Shaw, Nicholas E Larkey, Nicole V Tolan, Andrew Szczembara, Leslie J Donato, Robert D Maynard, Adil I Khan

2020-Current year OA Pubs

BACKGROUND: Point-of-care testing (POCT) has expanded rapidly across healthcare systems, increasing both program scale and operational complexity. However, quantitative benchmarking data describing how POCT programs are structured and supported across institutions remain limited.

METHODS: We conducted a cross-sectional survey to characterize POCT program support, including program scope, staffing, operational practices, governance, and challenges. The survey was distributed electronically through professional networks, and 93 institutional responses were analyzed. Descriptive analyses were performed, and derived metrics, including sites per point-of-care testing coordinator (POCC), were used to evaluate the relationship between program scale and staffing.

RESULTS: POCT programs demonstrated substantial variability in scale, …

No Evidence For Modulation Of The Readiness Potential By Respiratory Phase During Natural Breathing, Lucas Jeay-Bizot, Raniyah Chisti, Uri Maoz, Aaron Schurger

Psychology Faculty Articles and Research

Respiratory processes are increasingly implicated in shaping neural activity and behavior. Recent studies have reported a coupling between respiratory phase and the cortical readiness potential (RP), suggesting that breathing may modulate the neural processes preceding voluntary action. Here, using electroencephalography recordings in humans, we re-examine this claim using the original dataset and a new independent dataset, as well as in simulated data with no coupling. We show that the reported association arises from a confound: both RP amplitude and respiratory phase are coupled to movement onset. The original analysis does not control for this dependency, leading to a spurious effect …

Unmet Needs In Hospital Birth: Perspectives From Birthing Individuals And Opportunities For Occupational Therapy, Susan L. Iliff, Emily Bryant Schreiber

Internet Journal of Allied Health Sciences and Practice

Purpose: The primary purpose of this study was to explore the services mothers receive during hospital‑based labor and delivery and to identify perceived gaps in inpatient perinatal care. A secondary aim was to examine how these unmet needs may represent opportunities for occupational therapy involvement within hospital maternity settings. Methods: A convergent parallel mixed methods design was used with an anonymous electronic survey. Participants were eligible if they were 18 years or older and had given birth in a hospital within the past five years. Eighty‑one participants completed the survey, which included demographic questions, satisfaction ratings related to standard‑of‑care …

The Investigation Of Ground Reaction Forces To Validate Progression Of Plyometric Exercise: A Pilot Study, Bradley Bechard, Brett Walker, Peter Leno

Internet Journal of Allied Health Sciences and Practice

Purpose. Current approaches lack research toward rehabilitation of the lower extremity following injury regarding progression and the effects of ground reaction forces (GRFs) along the kinematic chain. A typical physical therapy protocol demonstrated the patients initially performing non-weight bearing, or open chain exercises followed by walking and running activities. This initial pilot study entertained the need for a more “seamless” progression of exercises to bridge the gap of GRFs when rehabilitating a weight bearing joint from walking-to-running in healthy individuals. Methods. 10 plyometric exercises were chosen for the study following careful review of evidence-based literature and researched protocols for strength …

The Impact Of A Board Preparatory Platform On First-Time National Physical Therapy Examination Pass Rates, Shuying Lin, Melanie Lauderdale, Alyssa Bradford, Michael Brown, Kimberly Holt, Madelaine Palen, April Coward, Evan Warnick

Internet Journal of Allied Health Sciences and Practice

Purpose: Performance on the National Physical Therapy Examination (NPTE) is a key indicator of academic quality in Doctor of Physical Therapy (DPT) programs. Although commercial board preparation tools are widely available, evidence of their effectiveness remains limited. This study aimed to evaluate the impact of integrating TrueLearn (TL), a board-preparatory platform, into a DPT curriculum and to examine additional predictors of first-time success on NPTE. Methods: This retrospective cohort study included 270 graduates from the University of Mississippi Medical Center DPT program (Classes of 2020–2025). Students in the Classes of 2024 and 2025 (n = 84) were exposed to TL, …

Knowledge Of Alzheimer’S Disease-Related Dementia In Down Syndrome: A Cross-Section Survey Of Rehabilitation Graduate Students, Alan F. Smith, Abigail R. Donaway

Internet Journal of Allied Health Sciences and Practice

Purpose: Adults with Down syndrome have an increased risk for Alzheimer’s disease–related dementia, often presenting with behavioral and functional changes rather than early memory impairment. Rehabilitation professionals may observe these changes across the lifespan; however, preparedness during professional training is unclear. This study examined graduate student knowledge of dementia in individuals with Down syndrome across rehabilitation disciplines. Methods: A cross-sectional survey was distributed to graduate students in speech-language pathology, occupational therapy, and physical therapy programs in the United States (N = 322). Outcomes included factual knowledge, recognition of stage-related characteristics, and familiarity with diagnostic and care considerations. …

Females With Urinary Incontinence Demonstrate Impaired Postural Stability, Jean L. Mccrory, Corrie Mancinelli, Kate Harrison, Samantha K. Rondini Monaco, Krystal L. Thomas

Internet Journal of Allied Health Sciences and Practice

Introduction: Females with urinary incontinence (UI) have an increased risk of falls.  Few studies have quantified postural control, namely center of pressure (COP) movement and vertical ground reaction force in static and dynamic tasks, in females with UI. Purpose: The aim of our study was to examine static and perturbed postural stability in females with UI compared to unaffected females. Methods: The study design was a between-group comparison (UI vs control) on our static outcome variables of anteroposterior and mediolateral COP sway, COP displacement, average and instantaneous maximum COP velocity, and standard deviations of anteroposterior and mediolateral COP movement and …

Current Status And Future Needs Of Audiology Services In Saudi Arabia: An Exploratory Study, Ahmad A. Alanazi, Alhanouf N. Alhathal

Internet Journal of Allied Health Sciences and Practice

Purpose: Audiology services in Saudi Arabia are expanding; however, workforce shortages, limited postgraduate training programs, and variability in specialized services may affect equitable access to care. This study aimed to examine the current status of audiology services in Saudi Arabia and identify future needs related to service availability, workforce capacity, and specialized clinical provision to support the development of equitable, standardized, and high-quality audiological care nationwide. Methods: An exploratory cross-sectional study was conducted among practicing audiologists across healthcare facilities in Saudi Arabia. Because a comprehensive national registry of audiology clinics is unavailable, a purposive convenience sampling strategy was used to …

Beyond The Classroom: Impact Of An Interprofessional Exertional Heat Stroke Simulation On Knowledge And Confidence, Hannah L. Stedge, Amanda Hawkes, Melani Kelly, Behle Burns, Sara Beaudry

Internet Journal of Allied Health Sciences and Practice

Purpose: The primary aim of this study was to examine the impact of a high-fidelity exertional heat stroke (EHS) live broadcasted simulation on the knowledge and confidence of a multidisciplinary group of healthcare professionals attending an interprofessional continuing education conference. Methods: Participants were eligible for this study if they were a credentialed athletic trainer, physician, or emergency medical services professional. Participants attended an interprofessional symposium on EHS which included didactic training sessions followed by a live broadcasted EHS simulation and group debrief. Participants completed the 29-item survey instrument modeled after the Emergency Medical Services Knowledge of Exertional Heat Stroke Questionnaire …

Examining The Influence Of Cognitive Load And Self-Efficacy On The Development Of Clinical Reasoning In The First Clinical Education Experience Of First Year Physical Therapy Students, Andrew S. Bartlett, Brittney Gunterstockman

Internet Journal of Allied Health Sciences and Practice

Purpose: Clinical reasoning is critical for effective decision-making and patient outcomes in physical therapy. Although self-efficacy, cognitive load, and clinical reasoning have been studied individually, limited research has examined these constructs holistically. This study explored the influence of cognitive load and self-efficacy on the development of clinical reasoning during the first clinical education experience of first-year Doctor of Physical Therapy students using a think-aloud protocol. Methods: All participants completed measures of self-efficacy (New General Self-Efficacy [NGSE], Physical Therapist Self-Efficacy [PTSE]) and cognitive load (intrinsic, extraneous, germane) before and after their first clinical education experience. Think-aloud protocols were conducted at …

Effectiveness Of A Training Program In Enhancing The Knowledge Of Intensive Care Unit Staff Regarding Emergency Response: A Quasi-Experimental Pre–Post Study, Abdulrahman Abbas Jasim, Shimaa Gomaa, Rofida Albash, Amira B Kassem, Shahab Abdulla, Ralela Makline, Mustafa Abbass

AUIQ Complementary Biological System

Background: Timely and effective emergency response by intensive care unit (ICU) staff is critical for patient outcomes. Objective: To evaluate the effect of a structured educational intervention on ICU staff knowledge of emergency response. Methods: A one-group quasi-experimental pre–post study was conducted among ICU healthcare professionals in Thi-Qar Governorate hospitals. Participants completed a validated questionnaire assessing emergency response knowledge before and after a structured lecture covering cardiopulmonary resuscitation (CPR), airway management, bleeding control, and the ABCDE protocol. Paired statistical analyses were applied, and p-values <0.05 were considered significant. Results: Forty-one participants completed both assessments. Significant improvements were observed in recognition …

Bridging Data Gaps In Retinal Imaging: From Structural Domain Adaptation To Topology-Aware Synthesis, Gözde Merve Demirci

Dissertations, Theses, and Capstone Projects

Comprehensive visualization of the retina is essential for diagnosing and monitoring blinding diseases such as Diabetic Retinopathy and Retinopathy of Prematurity (ROP), where pathological changes often extend beyond a single field of view. Despite significant advances in automated retinal image analysis, clinical deployment remains limited by two fundamental data gaps: a structural learning gap, arising from scarce expert annotations and poor generalization across imaging domains, and a spatial coverage gap, caused by the difficulty of acquiring multi-view retinal images in fragile populations. Although these challenges are often addressed independently, this dissertation argues that they are tightly coupled: accurate, …

Gene-Environment Interactions In Cardiovascular Aging: Volunteering, Polygenic Risk, And Biomarker Change In European And African Ancestry Populations, Seoyoun Kim, Byeongju Ryu, Erin Ware, Koichiro Shiba, Cal J. Halvorsen

Brown School Faculty Publications

Volunteering has been associated with better cardiovascular health, but whether this association varies by genetic susceptibility to cardiovascular disease remains unclear. This study examined associations between volunteering and cardiovascular biomarkers, assessed associations between biomarker-specific polygenic scores (PGSs) and these outcomes, and tested whether polygenic risk moderated volunteering–biomarker associations among U.S. adults aged 51 years and older.

Using Early And Periodic Screening, Diagnostic, And Treatment (Epsdt) To Improve Access To Obesity Pharmacotherapy: A Practical Guide For Clinicians Caring For Youth With Obesity Across United States Medicaid Programs:, Jaime M. Moore, Valerie M. O'Hara, Cassie Totman, Brooke Sweeney, Sarah Hampl, Alaina P. Vidmar

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Coverage of obesity pharmacotherapy for youth varies substantially across state Medicaid programs. This variability limits access to evidence-based treatment for pediatric obesity. The Early and Periodic Screening, Diagnostic, and Treatment (EPSDT) benefit is a federally mandated Medicaid provision requiring coverage of medically necessary services for individuals under age 21, even when such services are not included in standard state Medicaid benefits. Despite its broad scope, EPSDT remains underutilized due to limited awareness and operational complexity.

METHODS: We developed a clinician-facing, practice-oriented framework to operationalize EPSDT for pediatric obesity treatment. This approach integrates (1) review of federal EPSDT policy and …

The Rise And Fall Of Lateral Electrical Surface Stimulation (Less) Through The Lens Of Srs Archives., Ali Rezazadeh Shirazi, Jay I. Kumar, Katie Dold, George H. Thompson, Andrew G. King, Richard M. Schwend, John P. Lubicky, Jay Shapiro, Behrooz A. Akbarnia, History Committee Of The Scoliosis Research Society

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: Lateral electrical surface stimulation (LESS), commercially known as the ScoliTron™, emerged in the late 1970s as a noninvasive alternative to bracing for adolescent idiopathic scoliosis. Early clinical reports generated considerable enthusiasm and adoption, but the technique was ultimately abandoned. This study examined the rise and fall of LESS through a combined analysis of the Scoliosis Research Society (SRS) archives and published literature, with the goal of understanding factors that influence the adoption, evaluation, and abandonment of innovation in scoliosis care.

METHODS: A structured historical review was conducted using archival materials from the Scoliosis Research Society (SRS), including meeting abstracts, …

Patient-Specific Computational Fluid Dynamics Modeling Of Airway Collapse In Infants With Robin Sequence., Gautam Jalori, Michael Barbour, Michael Bindschadler, Kelly Evans, John P. Dahl, Alberto Aliseda

Manuscripts, Articles, Book Chapters and Other Papers

Robin Sequence (RS) is a congenital condition in which patients experience dynamic, periodic obstruction or collapse of the upper airway due to an underdeveloped jaw and a posteriorly displaced tongue. Current clinical techniques for evaluating airway obstruction do not provide quantifiable data and fail to account for the dynamic nature of obstruction or collapse. There is no standardized criterion to characterize obstruction or collapse severity. This study presents the first method that extracts airway motion from 4-dimensional computed tomography and performs a patient-specific, moving-mesh computational fluid dynamics (CFD) analysis of RS patients with complete airway collapse or obstruction. To quantify …

Diffusion-Informed Joint Segmentation Enhances Detection Of Thalamic Atrophy In Parkinson’S Disease, Gozde Kizilates-Evin, Ani Kicik, Emel Erdogdu, Dilek Betul Saridede, Sevim Cengiz, Basar Bilgic, Hasmet A. Hanagasi, Esin Ozturk-Isik, Tamer Demiralp, Ali Bayram

All Works

The thalamus is a critical subcortical hub that relays sensorimotor information and regulates higher-order cognitive processes. Accurate delineation of thalamic nuclei is essential for elucidating disease mechanisms and tracking clinical progression. In this study, we compared two segmentation approaches implemented in FreeSurfer: the conventional structural method and a joint framework that integrates diffusion tensor imaging. Magnetic resonance imaging (MRI) data from 24 healthy controls (HC), 27 patients with cognitively normal Parkinson’s disease (PD-CN), and 33 Parkinson's disease patients with mild cognitive impairment (PD-MCI) were analyzed. Segmentation methods were compared in HC to assess their effect on volume estimates. Group comparisons …

Postoperative Complications In Patients With Sickle Cell Disease After Total Shoulder Arthroplasty, Katie Zehner, Gwyneth C. Maloy, John Slevin, Wesley Day, Mitchell K. Ng, Xuan Luo, Jonathan N. Grauer, Arya G. Varthi

Rothman Institute Papers

BACKGROUND: Sickle cell disease (SCD) encompasses a spectrum of genetic hematologic disorders characterized by erythrocyte sickling. Patients may experience musculoskeletal manifestations, such as osteonecrosis, which may warrant consideration for total shoulder arthroplasty (TSA). While prior literature suggests patients with SCD more frequently suffer complications after orthopaedic procedures, this is not well characterized for TSA.

METHODS: Adult TSA patients (older than 18 years) were identified in the 2010 to 2023 PearlDiver M170 database. Patients with SCD were matched 1:4 to patients without SCD based on age, sex, and Elixhauser Comorbidity Index (ECI). Ninety-day postoperative complications, emergency department (ED) visits, and readmissions …

Micrognathia, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Emergency Contraception, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Longitudinal Association Between Midlife Cardiovascular Health And Cognitive Change In A Bi-Ethnic Cohort, Janette Vazquez, Rebecca Bernal, Luis Aguirre, Jesus D. Melgarejo, Gladys Maestre, Sudha Seshadri, Helen P. Hazuda, Chen-Pin Wang, Claudia Satizabal

School of Medicine Publications

Introduction: Midlife cardiovascular burden contributes to cognitive decline and dementia. However, research in diverse populations remains scarce.

Methods: We included 402 San Antonio Heart Study participants (1979–1988; midlife mean age 57.9 ± 3.8, 58.5% women, 52% Mexican American) later enrolled in the San Antonio Longitudinal Study of Aging (1992–2004). Midlife cardiovascular health was assessed using Life's Simple 7. Cognition was measured up to four times with the Mini-Mental State Examination. Generalized estimating equation models adjusted for age, sex, income, and education were used to relate cardiovascular factors to cognitive change. Sensitivity analyses evaluated attrition bias.

Results: Physical activity was associated …

Volume 32, Issue 3

Metro Denver Dental Society Articulator Magazine

The 3rd Quarter 2026 issue of the Articulator explores the evolving clinical, professional and personal challenges shaping dentistry today, from emerging aligner technology and periodontal science to leadership and professional well-being. Articles include:

• MDDS President Dr. J.R. Franco reflects on family history, justice, patient advocacy and the responsibility of dentists to create meaningful change through organized dentistry.
• Dr. Amisha Singh examines how service and achievement can become tied to professional identity, and encourages dental professionals to find purpose and worth beyond accomplishment.
• Ms. Laura Ramsey explores advances in clear aligner therapy, including digital workflows, artificial intelligence and 3D printing, while …

Aligner Technology Today:, Laura Ramsey

Metro Denver Dental Society Articulator Magazine

Clear aligner therapy continues to advance through digital scanning, AI, treatment-planning software and emerging 3D-printing technologies. This article explores how these innovations are improving efficiency and expanding treatment options while emphasizing that successful outcomes still depend on sound diagnosis, biomechanics and clinical judgment.

Department Of Health Exerts Strong Control Over Cbct In Dental Offices: Regulations, Adopted Over Objection From Nysda, Take Effect Immediately., Lance Plunkett Jd, Llm

The New York State Dental Journal

On July 22, the New York State Department of Health finally adopted an entire set of new regulations covering all aspects of ionizing radiation. Contained in Article 16 of Title 10 of the Official Compilation of Codes, Rules and Regulations of the State of New York (10 NYCRR), the new regulations repealed and replaced the old Article 16. It is important to note that the new regulations are in effect only in counties outside of New York City. Dentists in New York City should still rely on guidance from the city Department of Mental Health and Hygiene. The regulations contain …

Lidocaine Combined With Low-Dose Esketamine For Movement-Evoked Pain After Hepatectomy: A Double-Blind Randomised Controlled Trial, Yan Xu, Li Zhou, Qianqian Tang, Feng Yu, Jingwen Wu, Siyu Yan, Min Cai, Jialu Wan, Yi Kang, Lajing Luowu, Mengmeng Zhou, Lulong Bo, Daniel I Sessler, Chunling Jiang

Faculty, Staff and Student Publications

Introduction: Pain following hepatectomy may delay recovery and increase opioid use. We tested the primary hypothesis that combining lidocaine and low-dose esketamine would reduce movement-evoked pain 24 h after hepatic resection. We also evaluated whether this approach reduced opioid consumption and improved quality of recovery.

Methods: Patients having elective hepatic resections were allocated randomly to receive lidocaine-esketamine or placebo from induction of anaesthesia until the end of surgery. After surgery, patients allocated to lidocaine-esketamine were given a continuous infusion of lidocaine with esketamine for 72 h. All patients received transversus abdominis plane blocks with ropivacaine 2 mg.kg-1 after induction of …

Hydroxyethyl Starch And Perioperative Complications: A Systematic Review And Meta-Analysis, Daniel I Sessler, Lorenzo Pradelli, Massimiliano Povero, Daniel Chappell, E Wang

Faculty, Staff and Student Publications

Background: Based on renal injury reported in critically ill and septic patients, the U.S. Food and Drug Administration issued a black box warning regarding hydroxyethyl starch (HES 130/0.4) use in 2013 and expanded the warning to surgical and trauma patients in 2021. Similarly, the European Medicines Agency initiated withdrawal of hydroxyethyl starch in 2022. This study was a new meta-analysis focused on renal injury designed to complement a 2021 meta-analysis of perioperative hydroxyethyl starch use, adding 45 trials and 6,895 patients. The focus was acute kidney injury and preoperative-to-postoperative change in creatinine concentration in surgical patients.

Methods: This study searched …

Patient-Centered Imaging In Dentistry, Erika Benavides Dds, Phd, Fabiana Naomi Soki, James R. Geist Dds, Ms, Angela M. Hoikka, Dds, Ms

The Journal of the Michigan Dental Association

This clinical feature discusses joint guidelines by the ADA and AAOMR for patient-centered dental radiography and cone-beam computed tomography (CBCT), emphasizing individual risk-based needs rather than routine schedules. It covers the principles of radiation safety: justification, optimization (ALARA/ALADA), and dose limitation. The article maps out specific imaging modalities recommended for caries, periodontal disease, endodontics, orthodontics, implants, and TMJ disorders. Additionally, it summarizes Michigan's administrative rules for X-ray installation shielding, equipment alignment, stable mechanical support, operator positioning, and the mandatory radiography training program requirements for dental assistants.

Opportunities For Learning Through Object Exploration During Early Physical Therapy: Physical Therapists’ And Caregivers’ Assistance And Interference Behaviors, Michele Goncalves Maia

Dissertations, Theses, and Capstone Projects

Early physical therapy (EPT) for infants with motor delays has traditionally emphasized motor milestone acquisition, yet growing evidence indicates that motor and cognitive development are fundamentally interconnected. Grounded in embodied cognition and developmental cascade theories, this dissertation conceptualized object exploration as a primary mechanism through which infants learn during EPT and examined how intervention approaches and adult behaviors shape opportunities for object exploration. Using retrospective analyses of video-recorded EPT sessions, two studies investigated how intervention approaches and adult behaviors influence infants' opportunities to learn through object exploration. Study 1 compared object exploration in the START-Play (SP) intervention and Usual Care …