Digital Commons Network^™

Assessing Indoor Heat Vulnerability And Cooling Strategies In Three Mobile Home Communities In Boulder, Colorado, Usa, Mehdi P. Heris, Skye Niles, Alana Wilson, Megan Mccurdy, Amy Lacourse, Nick Lankau

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Extreme heat is an increasing public health and environmental threat shaped by both physical and social factors. This study assesses the vulnerability of mobile homes and their residents at three mobile home parks in Boulder, Colorado. We examined indoor temperature, housing conditions, and social and personal risk factors of the households. We monitored indoor and outdoor temperatures using 27 indoor and 5 outdoor temperature data loggers, comparing mobile homes with air conditioning, swamp coolers, and passive cooling designs. This work provides a detailed analysis of indoor temperature patterns and demonstrates how evaluating trends yields insights into the performance and effectiveness …

Multidomain Expert Evaluation Of Leading Large Language Models As Providers Of Vaccination And Preventive Medicine Information, Marcello Di Pumpo, Leonardo Villani, Vittorio Maio, Maria Rosaria Gualano, Eleonora Marziali, Lucia De Maio, Rossella Mancini, Stefania Boccia, Walter Ricciardi, Patrizia Laurenti

College of Population Health Faculty Papers

OBJECTIVES: Vaccination is one of the most effective public health interventions. Large language models (LLMs) show great capability for providing health information. This study compared the performance of ChatGPT 3.5 (G3E), ChatGPT 4o in English (G4E), Claude 3.0 (CDE), Gemini 1.5 (GME), and ChatGPT 4o in Italian (G4I) in delivering information on vaccination and preventive medicine.

STUDY DESIGN: Mixed-method analysis evaluating large language models.

METHODS: Twenty-six expert-designed healthcare scenarios were used to evaluate each model through an adapted DISCERN-based instrument. Four experts independently rated outputs across six domains: Information Reliability, Information Quality, Medical Appropriateness, Impact on Vaccine Hesitancy, Potential for …

Evaluating Chest-Worn Light Logger Adherence: Development And Application Of A Wear/Non-Wear Model, Carlyn Patterson Gentile, Adah Thomas, Ryan Shah, Blanca Marquez De Prado, Nichelle Raj, Christina Szperka, Geoffrey Aguirre

Student Papers, Posters & Projects

Light exposure plays an important role in overall health because it entrains circadian rhythms. Recent technological advances in wearable light loggers allow measurement daily light exposure habits. Using a chest-worn light logger, our goal was to (1) develop methodology for differentiating adherent versus non-adherent use, and (2) define differences in lighting intensity in indoor and outdoor environments, to improve data reliability in future clinical studies using this technology. Four testers used a 10-channel chest worn light logging device under different conditions of wear and non-wear (experiment 1), and another tester made measurements with the light logger across a variety of …

Narrative Discourse Predictors Of Response To Naming Intervention In Aphasia, Dirk B. Den Ouden, Laura Giglio, Sigfus Kristinsson, Leonardo Bonilha, Deena Schwen Blackett, Brielle C. Stark, Janina Wilmskoetter, Julius Fridriksson

Communication Sciences and Disorders Faculty Articles and Research

Purpose:

Method:

Extraction Of Key Themes In Online Health Discourse Using Unsupervised Learning And Large Language Models, Miranda G. Scully

Computer Science Senior Theses

Health online discussion boards are a modern platform that allow patients to interact with each other and the healthcare system as a whole, making them valuable sources of information for clinicians seeking to better anticipate treatment experiences and barriers. This study focuses on one such community, r/suboxone, a subreddit where patients using Suboxone share their experiences and ask questions. Our analysis is motivated by previous work that proposes event-based classification systems for such posts which buckets posts from r/suboxone into one or more of five high-level labels (Access Logistics, Co-Occurring Drug Usage, Medication for Opioid Use Disorder Administration, Psychophysical Effects, …

Rehabvr: A Virtual Reality System For Upper-Body Orthopaedic Physical Therapy Rehabilitation, Winnie Brenda Wanjiru Waiya

Computer Science Senior Theses

Physical therapy is a central component of rehabilitation for musculoskeletal conditions, yet adherence to prescribed treatment remains persistently poor. Jack et al. identified pain, boredom, and insufficient feedback as key barriers to treatment adherence in physiotherapy outpatient settings,¹ and Rucinski et al. confirmed that non-adherence rates in orthopaedic populations remain between 50 and 70%, with patients who disengage facing elevated risk of reoperation, progressive functional decline, and poor clinical outcomes.² According to the World Health Organization, approximately 1.71 billion people globally live with musculoskeletal conditions,³ with shoulder pain specifically carrying a community prevalence ranging from 0.67 to 55.2% worldwide and …

Growth In Early Infancy Drives Optimal Brain Functional Connectivity Which Predicts Cognitive Flexibility In Later Childhood, Chiara Bulgarelli, Anna Blasi, Samantha Mccann, Bosiljka Milosavljevic, Giulia Ghillia, Ebrima Mbye, Ebou Touray, Tijan Fadera, Lena Acolatse, Sophie E Moore, Sarah Lloyd-Fox, Clare E Elwell, Adam T Eggebrecht, Bright Study Team

2020-Current year OA Pubs

Functional brain network organisation, measured by functional connectivity (FC), reflects key neurodevelopmental processes for healthy development. Early exposure to adversity, for example undernutrition, affects neurodevelopment, observable via disrupted FC, and leads to poorer outcomes from preschool age onwards. We assessed longitudinally the impact of early growth trajectories on developmental FC in a rural Gambian population from age 5-24 months. To investigate how these early trajectories relate to later childhood outcomes, we assessed cognitive flexibility at 3-5 years. We observed that early physical growth before the fifth month of life drove optimal developmental trajectories of FC that in turn predicted cognitive …

Hypertensive Disorders Of Pregnancy, Covid And Readmission Status, Margaret Luebke, Ross Bindler, Trisha Saul, Linda Trinh

Publications 2026-present

No abstract provided.

Designing Robust Physiotherapy Trials: When And How To Use The Randomized Crossover Model, Manish P. Shukla, Gaurav Chhabra, Ashish Shankarrao Deshmukh, Neha Sachin Chaudhary, Neha Deshmukh

Internet Journal of Allied Health Sciences and Practice

Problem: Physiotherapy research increasingly requires methodological precision and clinical relevance. Among available designs, the randomized crossover model offers distinct advantages by allowing each participant to serve as their own control, thereby reducing inter-individual variability and improving statistical efficiency. Purpose: This perspective article discusses how appropriately designed crossover trials can enhance the quality and interpretability of physiotherapy research when applied under stable clinical conditions and with adequate washout periods. Methods: Three representative crossover studies illustrate these principles across physiotherapy specialties. In musculoskeletal practice, manual therapy for thoracic pain demonstrated measurable reductions in paraspinal electromyographic activity following counterstrain compared with spinal manipulation. …

Does The Availability Of An Additional Set Of Bunker Gear Impact Firefighter Health, Safety, And Operational Readiness?, Ryan Riley

Certified Public Manager® Applied Research

Firefighting is a complex and inherently dangerous profession. Firefighters today face a growing array of occupational hazards, not just from the effects of being exposed to fire and smoke, but also from the personal protective gear they wear, commonly referred to as “bunker” or “turnout” gear. While this gear is designed to protect firefighters in dangerous environments, prolonged use and repeated exposure to smoke, chemicals, and products of combustion can compromise the gear. Research has shown that bunker gear contains and can also retain cancer-causing chemicals. To this end, this paper examines whether the availability of an additional set of …

Optimizing The Sensitivity Of Detection Of Respiratory Syncytial Virus Infections In Longitudinal Studies Using The Combination Of Weekly Sample Testing And Biannual Serology., Shannon C. Conrey, Daniel C. Payne, Maria Deza Leon, Monica Epperson, Melissa M. Coughlin, Allison R. Burrell, Claire P. Mattison, Rachel M. Burke, Julia M. Baker, Natalie J. Thornburg, Meredith L. Mcmorrow, Mary Allen Staat, Ardythe L. Morrow

Manuscripts, Articles, Book Chapters and Other Papers

Cohort studies are often challenged by incomplete adherence to sampling regimens, limiting the full capture of disease burden. We describe the detection of respiratory syncytial virus (RSV) infections achieved in a birth cohort using a combination of weekly nasal sample testing and serology. The Pediatric Respiratory and Enteric Viral Acquisition and Immunogenesis Longitudinal Cohort followed 245 maternal-child dyads from birth to age 18 to 24 months. Weekly mid-turbinate nasal swabs were tested for RSV using real-time polymerase chain reaction (RT-qPCR). Serum was tested for RSV pre-fusion F IgG and IgA antibody at age 6 weeks and biannually from 6 to …

Bullying, Early Sexual Debut, And Sexual Health Behaviors Among Adolescents In New York City, Valentina I. Ramirez

Dissertations and Theses

Adolescent sexual and reproductive health remains a critical public health priority in the United States, particularly given the persistent burden of HIV and sexually transmitted infections (STIs) among young people. Adolescents and young adults account for a disproportionate share of STI cases, reflecting ongoing gaps in prevention, early detection, treatment, and equitable access to sexual health care and services. These patterns are shaped not only by individual behaviors but also by broader social, structural, and developmental contexts that influence adolescents’ opportunities to engage in preventive sexual health care.

This dissertation examined associations between early sexual debut, experiences of bullying, and …

Screen-Based Simulation Assessment For Emergency Medicine Learners: A Rapid Review, Patrick Zeniecki, Rebecca Kamens, Jared Kilpatrick, Dimitrios Papanagnou, Xiao C. Zhang

Department of Emergency Medicine Faculty Papers

BACKGROUND: Simulation has played a vital role in training medical professionals. The COVID-19 Pandemic has highlighted the need for physically distant educational assessment methods. Screen-based simulation (SBS) demonstrates one alternative to traditional in-person simulation methods to assess learners clinical reasoning and communication skills. This study aims to compare in-person simulation to SBS as assessment methods in Emergency Medicine (EM).

METHODS: A rapid review literature search methodology of an electronic database (PubMed) was performed in February 2022 with search terms such as "Computer Simulation," "Patient Simulation," "Simulation Training," "Education, Distance," "Virtual OSCE," "Academic Performance," or "Emergency Medicine." Reference lists of relevant …

From Performance To Practice: Knowledge-Distilled Segmentator For On-Premises Clinical Workflows, Qizhen Lan, Aaron Choi, Jun Ma, Bo Wang, Zhongming Zhao, Xiaoqian Jiang, Yu-Chun Hsu

Faculty, Staff and Student Publications

Deploying medical image segmentation models in routine clinical workflows is often constrained by on-premises infrastructure, where computational resources are fixed and cloud-based inference may be restricted by governance and security policies. While high-capacity models achieve strong segmentation accuracy, their computational demands hinder practical deployment and long-term maintainability in hospital environments. We present a deployment-oriented framework that leverages knowledge distillation to translate a high-performing segmentation model into a scalable family of compact student models without modifying the inference pipeline. The framework is primarily evaluated on nnU-Net, with additional validation across transformer and heterogeneous teacher–student architectures. The proposed approach preserves architectural compatibility …

Life Sustaining Well-Being Practices And Physiological Health Among Black Men, Dakota W. Cintron, Monique N. Golden, Jennifer M. Boylan, Julia K. Boehm, Tomiko Yoneda, Hebi Wang, Erik M. Hines, James L. Moore Iii

Psychology Faculty Articles and Research

Objective

To identify culturally grounded well-being practices among Black men in midlife and examine their associations with physiological health.

Methods

Analyzing data from the 2004–2005 Midlife in the United States (MIDUS) study, we examined, 116 open-ended responses to the question, “What do you do to make your life go well?” Network topic modeling identified six topics: (1) interpersonal kindness and positive mindset; (2) caring for children; (3) practicing spirituality and faith; (4) maintaining social connections and well-being; (5) avoiding stress; and (6) meaningful work and daily activities. Topic scores, reflecting participants’ tendency to discuss these themes, predicted allostatic load and …

Autoregulation Of Three Yeast Ribosomal Protein Genes By Splicing Inhibition, David Granas, Anirudh Kesanapally, Michael A White, Gary D Stormo

2020-Current year OA Pubs

Yeast ribosomal protein genes RPL18B, RPL28, and RPS22B are autoregulated by inhibition of splicing. This is demonstrated by inserting their introns into a chromosomal copy of GFP and observing repression upon induction of the cognate protein. In RPL18B and RPS22B, a predicted conserved secondary structure within the intron is required for regulation, while in RPL28, it is not.

Aphasia Therapy In An Arabic-Speaking Individual After Stroke: A Case Report, Mohammed F. Alharbi Dr

Internet Journal of Allied Health Sciences and Practice

Purpose: This case report describes the clinical application and preliminary outcomes of Arabic-adapted Semantic Feature Analysis (SFA), Phonological Components Analysis (PCA), and Verb Network Strengthening Treatment (VNeST) in an Arabic-speaking adult with post-stroke aphasia and highlights language-specific factors that affect the adaptation of these interventions to Arabic. Methods: The participant was a 53-year-old right-handed native Arabic-speaking man who developed moderate to severe nonfluent transcortical motor aphasia after a left middle cerebral artery stroke. One month after stroke onset, he underwent assessment with the Short Aphasia Test for Gulf Arabic speakers, which showed relatively preserved auditory comprehension and repetition but marked …

Student Perceptions Of Artificial Intelligence: A Freelisting Study, Gary Kaplan, Mslis, Ahip, Jessica G. Hamilton, Mls, Rebecca Miller, Mlis, Rosemary Frasso, Phd, Cph

Thomas Jefferson University Faculty Days

Background

Librarians typically provide guest lectures on topics in information literacy, connecting students to the scholarly literature. Hervieux & Wheatley’s Six Frames for AI Literacy emphasize the need to engage in AI discourse. As artificial intelligence changes the way students often interact with information, librarians must adjust their approach, whether changing the framing while retaining the traditional content, or changing the content. In the 2025-26 academic year, we experimented with various approaches. Here we describe a brief freelisting exercise we conducted before the lessons to surface students’ perceptions of artificial intelligence.

Molecular And Histologic Studies Of The Amygdala And Reward Circuits In Rhesus Macaques (Macaca Mulatta) With Self-Injurious Behavior (Sib), Jackie Barua

Doctoral Dissertations

Self-injurious behavior (SIB), also known as non-suicidal self-injury (NSSI), is characterized by deliberate infliction of harming one’s own body tissues without committing suicide, and persists in a group of captive rhesus macaques despite an enhanced enrichment program and pharmacological intervention with diazepam. The aim of this dissertation was to identify the neurobiological underpinnings of SIB by combining RNA-seq guided transcriptomic discovery and targeted candidate gene validation with unbiased histological and imaging analysis. The secondary aim was to employ a complementary mouse model to investigate the endogenous opioid system in response to diazepam. The amygdala transcriptome of primates with SIB (n …

Enhancing Hiv Prevention: Implementation And Evaluation Of A Standardized Hiv Risk Assessment Screening In A Primary Care Setting, William Duckworth

Doctoral Dissertations

Background: HIV remains a persistent public health concern, with 1.3 million people affected worldwide. Although advances in treatment have improved long-term management, early prevention still relies on identifying individuals at elevated risk. In many primary care settings, routine HIV risk assessment is inconsistent or absent, resulting in missed opportunities to screen, educate and initiate prevention strategies such as pre-exposure prophylaxis (PrEP). This gap underscores the need for structured, evidence-based tools to improve early risk identification and strengthen HIV prevention efforts. Purpose: Implement and evaluate an evidence-based standardized screening process for HIV risk assessment to achieve early identification and enhance appropriate …

Enhancing Hpv Vaccination Engagement And Uptake Among Young Adults Aged 17 To 26 Through A Multilevel, Multicomponent Intervention, Sarah Dianne Girlinghouse

Doctoral Dissertations

Background: Human papillomavirus (HPV) remains one of the most common vaccine-preventable infections, with vaccination rates among young adults aged 17 to 26 remaining below Healthy People 2030 targets. University health settings represent a critical opportunity to improve vaccine uptake. Prior to this quality improvement (QI) initiative, student health services (SHS) at a public university in the southern United States did not routinely offer HPV vaccination, resulting in missed opportunities for prevention. Evidence supports provider recommendation, clinical decision support, and improved access as key drivers of HPV vaccination uptake. Purpose: The purpose of this QI project was to increase HPV vaccination …

Liver Injury From Medications Used For Treating Inflammatory Bowel Disease: The Drug-Induced Liver Injury Network Experience, Harish Gopalakrishna, Jiezhun Gu, Yi-Ju Li, Huiman Barnhart, Dina Halegoua-De Marzio, Herbert L. Bonkovsky, A. Sidney Barritt, Jean P. Molleston, Naga P. Chalasani, Marwan Ghabril

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: We aimed to investigate and characterise DILI due to approved therapies for inflammatory bowel disease (IBD).

METHODS: Using the Drug-Induced Liver Injury Network (DILIN) prospective study, we evaluated definite, highly likely, or probable DILI attributed to IBD therapies, including use for non-IBD indications (but excluding corticosteroids). HLA allele associations were investigated.

RESULTS: Among 1806 participants, 81 (4.5%) had IBD-agent DILI: 31 biologics (27 infliximab), 35 immunomodulators (31 azathioprine/mercaptopurine), 14 aminosalicylates (11 sulfasalazine) and 1 small molecule (tofacitinib). Median age was 45 years with 75% female and 78% White. Patients with biologic-DILI were younger, had longer latency (median 124 days), …

Activated Dorsomedial Hypothalamic Astrocytes Regulate Feeding Behavior, Bella M. Lisenby

Honors Projects

The dorsomedial hypothalamus (DMH) region of the brain has been shown to be important for anticipatory feeding activity and play a role in restricting excessive food intake. In obese animals that overconsume calories, astrocytes within the DMH exhibit intracellular signaling changes indicative of cellular activation. Because astrocytes are known to influence neuronal function, we hypothesize that activated astrocytes regulate behavior. In the current study, we use chemogenetics combined with stereotaxic surgery to assess the contribution of astrocyte activity in the DMH towards metabolic behaviors.

Fentanyl Mediated Distortions Of Phasic Dopamine Release Dynamics Encoding Natural Reward And Aversive Processing In The Mammalian Mesolimbic Circuit, Oliver P. Culver Iv

MUSC Theses and Dissertations

Mu opioid receptor (MOR) agonists are recognized to disinhibit tonic dopamine (DA) in the ventral striatum (VS), contributing to opioid addiction and euphoria. However, MOR agonists can also inhibit non-drug reward-seeking, and disrupt conditioned responding to aversive stimuli, a phenomenon not readily explained by tonic DA disinhibition. We hypothesized that this effect could be due in part to disruption of phasic DA responses to conditioned stimuli (CS) which critically shape and maintain behaviors during naturalistic reward and aversive processing. Because MOR effects on CS-evoked phasic DA are largely unexamined, we conducted in vivo fiber photometric recordings in water-deprived male and …

Reality Check: Examining Perceived Stress In Student Pharmacists Using Virtual Reality, Kimberly B. Garza, Channing R. Ford, Kristen L. Helms

The Journal of Advancing Education Practice

The impact of stress on learning is complex and multifaceted, and there is a balance between stress that promotes learning and that which inhibits it. This study presents a qualitative analysis of students’ responses to a questionnaire about their experience using virtual reality (VR) in a perspective-taking task to promote empathy for patients with physical limitations due to arthritis of the hands. Including data collected from a first-year course in 2023, 2024, and 2025, 214 students ranked their stress while experiencing the task, and those who ranked stress as anything other than “no stress” were asked to elaborate on the …

An Exploration Of The Intersection Of Artificial Intelligence And Speech-Language Pathology -- Potential Impacts, Manish K. Rami

Internet Journal of Allied Health Sciences and Practice

Purpose: This paper explores the potential impact of Artificial Intelligence (AI) on the profession of Speech-Language Pathology (SLP). AI is widely recognized as a transformative force, presenting opportunities across both service delivery and professional practice in SLP. Method: The analysis employs the American Speech-Language-Hearing Association's  Scope of Practice in Speech-Language Pathology as an organizing framework to systematically evaluate AI applications across professional and service delivery domains. Within each domain, the study identifies emerging use cases, evaluates the capacity for AI technologies to automate or augment clinical processes, and examines broader implications for the profession, with particular attention to anticipated changes …

An Analysis Of Dei Preparation In Health Science Programs For Future Healthcare Providers, Michael Holik, Scott Heinerichs

Internet Journal of Allied Health Sciences and Practice

Purpose: Research has indicated patients have better outcomes when their healthcare providers are comprehensively trained in diversity, equity, and inclusion (DEI) related areas during their academic preparation. By understanding students’ perceptions of the DEI education, they receive and knowing how that training may impact future patient interactions, educators can allow educational programs to prepare health science students better. This study aimed to garner and examine the perceptions health science students have on the DEI education they receive as undergraduate and/or graduate students in a regional public comprehensive university. Methods: Upon approval of research from the Institutional Review Board, 2,700 health …

Student Perceptions Of Clinical Educator Competence Across Healthcare Professions, Samar Long, Sarah Varekojis, Tonya Apke, Erika Kemp

Internet Journal of Allied Health Sciences and Practice

Background: Educational units that house a variety of healthcare programs require unique skills and knowledge development and vastly different professional responsibilities. The training for students is similar in that they use clinical educators to provide practical educational experiences. Purpose: The purpose of this study is to explore healthcare students' perceptions of their clinical educators' skills across six domains related to clinical education for six health professions. Methods: The data collection process involved a survey of students who have completed clinical rotations with at least two different clinical educators. Results: Seventy-four responses were included in data analysis. Students have positive perceptions …

Radiographic Assessment Of Morphometric Knee Angles In Patellofemoral Pain Syndrome: A Quantitative Cross-Sectional Study, Sandhya Nagolu, Lavanya Prathap, Subhadra Devi Velichety, Jeyakumar S, K.Venkata Naga Prahalada

Internet Journal of Allied Health Sciences and Practice

Purpose: Patellofemoral Pain Syndrome (PFPS) is one of the most common causes of anterior knee pain, but its radiographic diagnostic indicators are still not clearly defined. This study aimed to evaluate key radiographic morphometric parameters, including Q angle, sulcus angle, patellar tilt angle, and Insall–Salvati ratio in individuals with PFPS compared with healthy controls and to determine their association with anthropometric variables. Methods: A quantitative cross-sectional study was carried out involving 110 individuals diagnosed with patellofemoral pain syndrome (PFPS) and 110 age- and sex-matched asymptomatic controls. Standardised digital radiographs were analysed using INSTARISPACS software to obtain morphometric measurements. Statistical analyses …

Postural Rehabilitation In The Management Of Chronic Neck Pain: A Comprehensive Literature Review, Yashfa Arman

Internet Journal of Allied Health Sciences and Practice

Purpose: This systematic review synthesizes current evidence on the efficacy of major postural rehabilitation techniques for chronic neck pain. Method: A systematic literature search was conducted in PubMed, Scopus, and PEDro databases up to May 2024. Randomized controlled trials and systematic reviews investigating posture-focused interventions for adults with non-specific chronic neck pain were included. Results: Seventeen studies met the inclusion criteria. Findings indicate that all techniques are effective, but each excels in distinct domains. Neck-specific exercises provided the most significant reduction in pain intensity (up to 58%) and functional disability. Global Postural Re-education (GPR) demonstrated superiority in improving objective measures …