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Bovine Testicular Antihyaluronidase In Rabbits: Production And Purification, Gerald Fine, Sheikh M. Saeed, Gerald A. Logrippo

Henry Ford Hospital Medical Journal

An antibody chemically and immunologically active against bovine testicular hyaluronidase was produced in rabbits by injecting them with purified hyaluronidase in complete Freund's adjuvant. Nonspecific antibodies, reacting with human and bovine proteins which had little or no hyaluronidase activity, were also detected by the double agar immunodiffusion technique using antiserum against these proteins. After absorption of the antiserum with bovine heart and liver and removal of the precipitation bands against human and bovine tissue proteins, the antiserum inhibited the chemical activity of the purified hyaluronidase and exhibited immunologic activity against the purified hyaluronidase as shown by the agar double immunodiffusion …

Hfh In The News

Henry Ford Hospital Medical Journal

No abstract provided.

Calf Diarrhea (Scours): Reproduced With A Virus From A Field Outbreak, C. A. Mebus, N. R. Underdahl, M. B. Rhodes, M. J. Twiehaus

Nebraska Agricultural Experiment Station: Historical Research Bulletins

Neonatal calf diarrhea typical of that seen in field cases was produced in colostrum-deprived calves by inoculating either feces or bacteria-free filtrates via the duodenum, orally, or by a spray (aerosol). Three calves, kept free of E. coli, developed severe diarrhea following inoculation with a bacteria-free filtrate. Intense fluorescence in the epithelium of sections of small intestine from two experimental calves was observed following staining with ftuorescein-labeled gamma globulin produced with viral antigen prepared from the feces of two experimental diarrhetic E. coli-free calves. Fluorescing cells were also present in the feces of experimental and field cases of neonatal …

Newsletter, Volume 14, Number 01, March 1969

Newsletter: A Report to Physicians of Texas Archives

• Southern Pacific Donates Hospital To MDAH for Rehab Center
• Dr. Schellhas Wins Award
• Clinical Abstracts
• Holleb Named VP
• Freireich Joins Leukemia Society Board
• Linear Accelerator to be Largest For Clinical Use
• Genetics and Cancer is Subject of 23rd Symposium
• Breast Cancer discussed at 13th Clinical Conference
• Pathology and Breast Cancer
• 12th Year Book of Cancer Published
• MDAH Hosts Physicians From the Far East and Oceania
• Staff Publications
• New Staff
• MDAH Staffer Qualifies on EEG Society National Exam
• Science Students Work With Staff
• Three MDAH Fellows
• Radiology Fellows

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 5 No. 2

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

On The Antiquity Of Man, Roland Schmidt

MCV/Q, Medical College of Virginia Quarterly

Man is now lord of the earth and of the beasts and flowers, but he took millions of years to achieve his dominion. Two events more than others made man capable of his exercise of power. 1) A slowly achieved adaptation of man himself increased his potentialities far beyond those of other animals. The first step was man's gradual assumption of the erect posture. This put him on his peculiarly successful evolutionary path. It freed his hands and opened the way for the development of the central nervous system which made man unique in his capabilities. 2) A late revolution …

The Role Of Operations Research In A University Hospital: A Review And Bibliography, S. J. Kilpatrick Jr.

MCV/Q, Medical College of Virginia Quarterly

In the 1968 Annual Report of the Medical College of Virginia (Bulletin, 1968, pp8,18) the shortage of trained medical personnel is stressed as a serious problem in the care of the sick. As a result of this personnel shortage, approximately 100 beds have recently been closed in the University Hospital. This underlies the need for large medical centers to use O.R. techniques in developing more efficient use of existing medical personnel and in seeking cost reductions while increasing the quality and coverage of medical care. When the medical center is a component of an urban university, both urban and medical …

Perspectives In The Behavioral Sciences, Douglas D. Bond

MCV/Q, Medical College of Virginia Quarterly

It is clear at this moment that we have two major thrusts. The first is the unlocking of the biological secrets surrounding the potential for development and the fixing of learned material in the biological matrix. The second is the careful examination of the culture that will be learned. Here, not only every social scientist but every citizen need be concerned. The present emphasis upon the importance of culture can hardly be exaggerated unless it crowds out our interest in the biological. Man remains an enigma; reason, a personal control of prejudice, and a continuing spirit of disciplined inquiry are …

Laboratory And Clinical Studies Of Cardiac Transplantation, Richard R. Lower, V. Eric Kemp, Walter H. Graham, David H. Sewell, Hermes A. Kontos, George M. Williams

MCV/Q, Medical College of Virginia Quarterly

Cardiac transplantation was carried out on four patients at the Medical College of Virginia between May and October of 1968, in an effort to salvage them from the terminal stages of otherwise uncorrectable heart disease. Despite a strikingly good early recovery from operation in each case, three of the patients died of acute homograft rejection in one to three weeks; our second case is living and well, ten months after operation, and is at this writing the world's third longest survivor. The world experience to June of 1969 includes about 130 cardiac transplants. Of the first 100 patients operated on …

Induction Of Immunological Tolerance To Tissue Allografts With Antilymphocyte Serum, Anthony P. Monaco, Mark A. Hardy

MCV/Q, Medical College of Virginia Quarterly

Our interest in the problem of tolerance induction is directly concerned with clinical organ transplantation. ALS is highly effective in depressing cellular immunities. Since at least initial allograft rejection is predominantly a cellular phenomenon, one would expect ALS to be highly effective clinically. Our initial observations in this regard support this concept. However, non-specific depression of cellular immunity may also lead to an increased number or viral, fungal, and protozoan infections. Experiments, such as these presented, strongly suggest that a specific state of tolerance to organ grafts in man should be attainable with the aid of ALS followed by introduction …

Tissue Typing, Ronald T. Rolley

MCV/Q, Medical College of Virginia Quarterly

At present, histocompatibility matching is an inexact science, and there are undoubtedly many histocompatibility antigens either poorly defined or undefined. With further definition of such antigens, improvement can be expected in the correlation of tissue typing with homograft function and survival. Further work also needs to be done to determine which method of tissue typing is best.

Volume Five Subject Index

MCV/Q, Medical College of Virginia Quarterly

Subject index for MCV/Q, Medical College of Virginia Quarterly, Volume Five.

Onset Of The Immune Response, S. G. Bradley

MCV/Q, Medical College of Virginia Quarterly

In our studies on the primary immune response, we have used germfree, colostrum-deprived swine taken three to five days prematurely by hysterectomy. These piglets lack gamma globulin until they are immunized. Upon antigenic stimulation, early macroglobulin antibody is produced within 48 hours; subsequently late euglobulin antibody is produced. Our results have led me to formulate a new instructive model for the onset of antibody formation.

The Interplay Of Defense Mechanisms Against Infectious Diseases, Quentin N. Myrvik

MCV/Q, Medical College of Virginia Quarterly

The total complex of immune expression is an interplay between nonspecific antimicrobial humoral systems plus specific antibodies and accessory factors. These systems are backstopped by the phagocytic functions of PMNs. If these fail, mononuclear phagocytes respond as a second line of defense to carry out chronic engagements. In addition to a direct activation process by "substrate," macrophages may be activated and mobilized by a lymphocyte-mediated immunologic reaction which probably involves either a "lymphotoxin" and/or a specific antibody cytophilic for macrophages. Immunologically activated lymphocytes appear to be the primary effector cells of anti-tissue (transplantation) cellular immunity, whereas immunologically activated macrophages appear …

Isolated Organ Perfusion: Physiology And Application, William E. Gayle Jr.

MCV/Q, Medical College of Virginia Quarterly

Isolated organ perfusion provides us with an excellent tool for investigating the physiology and the function of a variety of individual organs. It enables us to explore these organs, their pharmacologic reactions, their ability to withstand various stresses, their pathology after stress and their suitability for preservation and transplantation. Isolated perfusion has allowed us to better understand hemodynamics, effects of various perfusates, and toxicity of drugs on individual organs. We have recently been enlightened about the vital role of platelets and endothelial integrity. We now have a model for assessing individual hormonal systems and qualitative and quantitative endocrine and exocrine …

The Role Of Preservation In Transplantation, Folkert O. Belzer

MCV/Q, Medical College of Virginia Quarterly

Although it is too early to draw any definite conclusions from these results, as a period of two years is probably necessary to evaluate cadaver kidney transplantation in humans, it appears that our well-matched patients have much fewer problems than our poorly matched patients. It is hoped that by preservation methods such as those discussed, improved methods of tissue typing, and better immunosuppressive therapy, we will be able to raise the survival level of cadaver kidney transplantations to the level between 80 and 85% presently being obtained in transplantations using living, related donors.

Histamine And Thyroid Hormone Function, Richard W. Schayer

MCV/Q, Medical College of Virginia Quarterly

Briefly, it will be postulated that a major function of thyroid hormone is for slowly developing adaptations of the circulatory system to environmental changes, and that many thyroid hormone effects are secondary to altered perfusion of tissues. There is no known in vitro effect of thyroid hormone which can reasonably explain any major number of the in vivo effects (Tata, 1964).

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 5 No. 4

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

Two Causes Of Reduced Profit From Pigs, G A L Ward

Journal of the Department of Agriculture, Western Australia, Series 4

LOSS of condition in a pig affects profits more severely than slow rate of growth.

Two common symptoms, scouring and itching, cause weight loss and are followed by a period of reduced weight gain.

Protection For Animals In Biomedical Research, F. L. Thomsen

Laboratory Experiments Collection

Our conclusion from all of this work and study is that not just a small part, but that most of the suffering undergone by laboratory animals in "unnecessary" under the terms of the pain provisions of the Rogers-Javits bill. Granted, it will take some time and effort to bring about the necessary interpretations of these provisions. The Act, when passed, offers us the medium through which to obtain such interpretations.

This unnecessary suffering results mostly from the indifference, and from the inertia and the lack of proper scientific training and technical knowledge, of many of those conducting laboratory animal experiments …

Problems In Transportation Of Animals, Alice M. Wagner

Animal Welfare Collection

This afternoon we are considering the problems involved in the transportation of animals. Undoubtedly we have all had people problems as we travel by car, train and by air, and with the increase of travel things seem to be growing worse instead of better. I commuted from my home in New Jersey to Philadelphia for 18 1/2 years - a round trip of five hours - so I know plenty of things that can happen in transportation and commutation.

So it is with animals. An increasing number of animals are being shipped - shipped as pets, shipped as meat animals, …

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 5 No. 1

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

Investigations On Congenital And Induced Osteopetrosis, Donald G. Walker

MCV/Q, Medical College of Virginia Quarterly

Osteopetrosis, or marble bone disease, is a disturbance of skeletal development in which the rate of bone resorption fails to keep pace with the rate of bone formation. Bone matrix accumulates excessively throughout the skeletal system, causing damage to neighboring tissues--particularly the dental, hematopoietic and nervous tissues. The line of investigation on osteopetrosis which has led to the current point of view that the thyroid gland represents the primary side of the disturbance was initiated soon after an experimental animal became available.

Thermodes And Theories, Herbert N. Spector

MCV/Q, Medical College of Virginia Quarterly

This brief outline reviews some of the important studies done with various types of thermodes employed for heating or cooling loci in the brain and discusses some sources of the findings relevant to our understanding of temperature regulation in mammals.

Abstracts Of Theses For Graduate Degrees

MCV/Q, Medical College of Virginia Quarterly

Medical College of Virginia, June, 1968. Summary includes: Studies on Sulfonamides: Physiochemical Properties in Relation to Biological Activity by Richard Charles Allen; The Incisures of Schmidt-Lanterman by Nabil A. Azzam; Loosely Linked Mutations Enhancing L-Arabinose Utilization in Escherichia coli B/r by Robert G. Bost; Induction of Fusion in Cultured Cells in the Presence of Para-influenza 3 Virus by Mildred Kaiser Fleetwood; Correlations Between Acid-Base Behavior and Ion Fluxes in Frog Skin by Ruth Torvik Friedman; The Mating Pattern of Five Strains of Drosophila equinoxialis by Ragnit Geeraets; The Intrinsic Back Musculature of Macaca mulatta by Robert M. George; Mechanical Effects …

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 5 No. 3

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

Cellular Rejection, James S. Wolf

MCV/Q, Medical College of Virginia Quarterly

Mounting experimental data suggest that the homograft reaction is intimately related to the small lymphocyte. It is evident that both the afferent and efferent arcs of transplant immunity are dependent upon the intactness of the lymphoid system. The lymphocyte has the ability to recognize the foreign antigen, is involved in the activity of cell-bound antibodies, and may be involved in the inductive processes leading to antibody formation.

The Use Of Pickled Wheat In Poultry Feeding, P Smetana

Journal of the Department of Agriculture, Western Australia, Series 4

FEEDING fungicides to poultry can result in harmful effects, to the birds themselves, and to their human consumers.

To prevent such effects it is advisable that wheat pickled with fungicides should not be included in poultry rations.

Black-Leg In Cattle, F C. Wilkinson

Journal of the Department of Agriculture, Western Australia, Series 4

BLACK-LEG is still a serious disease of cattle in the South West coastal region, causing deaths in young cattle.

The disease is characterised by hot swollen muscles, acute lameness and rapid death.

Cattle affected are usually 6 to 12 months old, in fat condition, and grazing on lush pastures.

Can Mastitis Be Eliminated?, F C. Wilkinson

Journal of the Department of Agriculture, Western Australia, Series 4

Can mastitis be eliminated from a dairy herd? The results of a 12-month continuous study of four commercial herds show that it could be done.