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Distribution Of Maternal And Fetal Blood Flow Within Cotyledons Of The Sheep Placenta, Gordon G. Power, P. Steven Dale, Paul S. Nelson

Loma Linda University Electronic Theses, Dissertations & Projects

These studies explore the distribution of blood flow among small samples of placental tissue. Labeled microspheres (14 ± 1 pm) were Injected Into the left ventricle of six un-anesthetized ewes and Into the jugular vein of the fetus In utero. A total of 3,576 samples weighing 31. +11. (S.D.) mg were taken from seventeen cotyledons and counted for flow labels. Maternal and fetal flow within the cotyledons were both normally distributed with standard deviations of 44%. The maternal/ fetal flow ratio was less than 0.5 In 9% of the cotyledon, between 0.5 and 1.5 In 70%, and greater than 1.5 …

Analysis Of The Potentials And Topographical Relations Between The Olfactory Bulb And Prepyriform Cortex, William S. Seibly

Loma Linda University Electronic Theses, Dissertations & Projects

Olfactory bulb efferents sweep caudally over the prepyriform cortex in a broad fiber sheet called the lateral olfactory tract (LOT). The LOT begins as a compact sheet of fibers in the olfactory peduncle and narrows to a bundle caudally. It is the primary axonal pathway between the olfactory bulb and the cortex. The shape and cross-sectional area of the LOT was measured from histologic sections. The cross-sectional area diminishes to about half from rostral to caudal measurements. An array of 58 electrodes spaced at intervals of 1 mm was constructed to conform to the curvilinear surface and geometry of the …

The Effect Of Natural Measures To Aid In Sleep As Compared With The Use Of Flurazepam 30 Milligrams As Seen In The Hospitalized Male Patient, Myra Ladd Thompson

Loma Linda University Electronic Theses, Dissertations & Projects

Sleep is necessary for physical and psychological restoration of the body. Studies indicate that tissue repair is augmented during sleep, showing that rates of protein synthesis and of mitotic division are higher at times of rest and sleep. Studies evaluating sleep-deprived subjects reveal that after loss of normal sleep, some types of memory and learning processes are impaired. These subjects generally become anxious and irritable, especially after loss of dreaming sleep.

Sleeping medications have been implicated by observers and researchers to be a cause of altered sleep patterns. These medications not only disrupt normal sleep cycles, but their continued use …

The Effects Of Prostaglandin Synthesis Inhibition On The Regulation Of Blood Pressure In The Rat, David J. Pollock

Masters Theses

No abstract provided.

Summer 1980, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Summer 1980

Mechanical, Electrical And Anesthetic Stunning Methods For Livestock, Temple Grandin

International Journal for the Study of Animal Problems

A good stunning method must render an animal unable to experience pain and sensation prior to hoisting and slaughter. The three basic types of stunning methods which are classified as being humane (i.e., pain less) in the United States, Europe and other foreign countries are captive bolt (penetrating and nonpenetrating), electrical, and CO₂ (carbon dioxide) gas anesthesia.

The physiological mechanisms of stress are the same before and after the onset of unconsciousness. The release of epinephrine as a result of stress inducers has an effect on the quality of the meat and it is therefore desirable to use a …

Newsletter, Volume 25, Number 04, July - August 1980, Murray M. Copeland Md

Newsletter: A Report to Physicians of Texas Archives

• Two Construction Projects Approved
• Scientific Abstracts
• Junior Science Trainees Complete Summer Study
• Cancer Project Director Reports Progress, Murray M. Copeland, MD
• Hickey Compares MDAH With Community Hospital
• DOE Awards Grant for Energy Study
• Noteworthy
• Administration Announces New Staff Appointments

Cellular Action Of Vasopressin In Medullary Tubules Of Mice With Hereditary Nephrogenic Diabetes Insipidus, Brian A. Jackson, Richard M. Edwards, Heinz Valtin, Thomas P. Dousa

Dartmouth Scholarship

Our previous studies (1974. J. Clin. Invest.54: 753-762.) suggested that impaired metabolism of cyclic AMP (cAMP) may be involved in the renal unresponsiveness to vasopressin (VP) in mice with hereditary nephrogenic diabetes insipidus (NDI). To localize such a defect to specific segments of the nephron, we studied the activities of VP-sensitive adenylate cyclase, cAMP phosphodiesterase (cAMP-PDIE), as well as accumulation of cAMP in medullary collecting tubules (MCT) and in medullary thick ascending limbs of Henle's loop (MAL) microdissected from control mice with normal concentrating ability and from mice with hereditary NDI.

Adenylate cyclase activity stimulated by VP or by …

A Comparative Study On The Frequency Of Respiratory, Gastrointestinal, And Allergic Disorders Between Bottle-Fed And Breast-Fed Infants From Birth To Twelve Weeks Of Age, Sylvia C. Souza

Loma Linda University Electronic Theses, Dissertations & Projects

Questions concerning the advantages of breast-feeding have been debated since the introduction of commercially-prepared formula about 50 years ago. Some recognized benefits of breast milk include less respiratory as well as other Infections, less allergy in infancy and later life, and a lower morbidity rate in less-developed countries. From 1955 to 1971 in the United States there was a decline in the incidence of breast feeding related to several factors which included the introduction of formula, mothers returning to the work force, and strict maternity units' rules and routines. Since 1971 to the present there has been a resurgence in …

The Effects Of 712-Dimethylbenz (A) Anthracene On Ovarian Steroidogenesis And Uterine Growth In The Mouse, Jeffrey Lynn Clark

Biological Sciences Theses & Dissertations

It has been previously demonstrated that 7,12-dimethylbenz(a) anthracene (DMBA) is an initiator of ovarian granulosa cell tumors. It is also known that DMBA leads to destruction of primordial oocytes, and that tumor induction may involve the interaction of pituitary gonadotropins. However, the effects of DMBA on ovarian steroidogenesis and uterine growth in relation to the tumorigenic process have not been investigated. Therefore, the present study was conducted to examine these parameters using adult C57Bl/6N mice treated in proestrus and diestrus II with 0.1 ml corn oil with or without 1.5 mg DMBA and killed 44 hours later. The uteri and …

The Analysis Of S-Adenosylmethionine And S-Adenosylhomocysteine In Normal And Neoplastic Cells, Kathryn Elizabeth Godburn

Chemistry & Biochemistry Theses & Dissertations

Altered patterns of methylation have been shown in both ribosomal and transfer RNA isolated from cancer cells. In contrast to the elevated activity of the methyltransferases responsible for this modification, hypomethylation appears as a general characteristic. The endogenous levels of S-adenosylmethionine and S-adenosylhomocysteine are important in relationship to their role as substrate and product of the transmethylation reaction. The levels of S-adenosylmethionine and S-adenosylhomocysteine were determined using phosphocellulose cation exchange or high pressure liquid chromatography. High voltage paper electrophoresis was used in a modified procedure to directly resolve (³⁵s) labeled S-adenosylmethionine and S-adenosylhomocysteine in small quantities of cell …

Multiple Forms Of Nicotinamide Adenine Dinucleotide Glycohydrolase From Bull Semen, Stanley D. Yeatts Ii

Chemistry & Biochemistry Theses & Dissertations

Nicotinamide adenine dinucleotide glycohydrolase (NADase) of bull semen is an extracellular, soluble enzyme capable of catalyzing the hydrolysis of the nicotinamide N-ribosidic linkage of NAD⁺. In search for a rapid, simple procedure for the preparation of this enzyme, it was found that Matrex Gel Red A (Amicon) column packing served very well as an affinity gel for NADase. The enzyme was applied to the Matrex Red A column (21 cm x 1.5 cm) in 10 mM sodium phosphate buffer, pH 6.0. Surprisingly, two fractions of NADase activity were obtained when the column was eluted with a sodium chloride …

The Effect Of Periapical Inflammation On Cellular Cementum : A Scanning Electron Microscope Study, Gary S. Yonemoto

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to obtain information on the morphologic changes that occur in cellular cementum exposed to periapical inflammation.

Ten single rooted human teeth were collected. There were five specimens of normal cellular cementum and five specimens of diseased cellular cementum, which had been exposed to periapical inflammation. Each specimen was fractured longitudinally through the apical foramen, leaving the organic component intact. The cross-sectional morphology of cellular cementum was then examined using an ARM Model 1000 scanning electron microscope. Energy dispersive x-ray spectrometry was also conducted on samples representative of the two test groups.

A methodology was …

Changes Of The Marginal Periodontium As A Result Of Labial Tooth Movement In Monkeys, Gregory G. Steiner, J. K. Pearson, J. Ainamo

Loma Linda University Electronic Theses, Dissertations & Projects

Orthodontic tooth movement was performed on five monkeys (Macaca nemistrina). Oral health was established and exploratory surgery was performed to assess the level of the connective tissue attachment and marginal bone. Measurements of the gingival margin and mucogingival junction were taken and orthodontic forces were applied. The central incisors were moved labially a mean distance of 3.05mm. Post therapy measurements were performed to assess the change which occurred as a result of tooth movement. Significant recession of the gingival margin, connective tissue level and marginal bone was found when compared to an amalgam marker located on the facial surface of …

Review Of Prognostic Factors For Esophageal Voice, Christine G. Bravos

Loma Linda University Electronic Theses, Dissertations & Projects

Plan A of this study was completed. Plan B of the study is the subject for future research. A review of the laryngectomy literature, from the earliest mention of the laryngectomy surgical procedure to the present was conducted; with specific emphasis upon factors pertinent to laryngectomee rehabilitation and esophageal speech development. Psychological, idiosyncratic, social, therapeutic and physiological factors were reported as affecting esophageal voice development. There were a great diversity of variables that might be predictive in judging acquisition of esophageal voice. However, much of the information regarding predictive variables was based on subjective reports, poorly controlled statistical research, or …

Lipoprotein Lipase Inhibitor Removal During Ultrafiltration Of Renal Failure Patients, Alisa Minear

Loma Linda University Electronic Theses, Dissertations & Projects

Plasma samples were obtained from seven hypertriglyceridemic (>150 mg/dl) chronic renal failure patients before and after regular hemodialysis. The effect of the plasma on the lipolytic activity of bovine milk lipoprotein lipase was investigated. The lipoprotein lipase activity, as measured by release of C¹⁴-labeled free fatty acid from triglyceride, was decreased 8-67% when incubated with uremic plasma as compared to the control plasma (44 mg/dl triglyceride). The inhibition noted prior to hemodialysis did not appear to be alleviated by the dialysis but subsequent treatment with an isolated ultrafiltration technique did appear to remove an inhibitory substance as …

Toxicity Of Root Canal Filling Materials On Hela Cells And Fibroblasts, Eldon P. Carman

Loma Linda University Electronic Theses, Dissertations & Projects

A study was undertaken to determine the concentration at which a sealer reaches a point of nontoxicity. An in vitro model utilizing HeLa cells and human fibroblasts was used to observe the effect of various concentrations of eight freshly mixed and eight set root canal sealers. Evaluation of toxicity was determined by cell survival which was measured by incorporation of ³H-thymidine into the nucleic acid components of each cell type used. Each dilution tested was allowed direct contact with the cells for 24 hours before toxicity evaluation. The results indicate that all sealers at concentrations presently used are cytotoxic …

Orthognathic Surgical Expansion Procedure Of The Mandible Of Female Baboon Papio Sp?, Willis L. Schlenker

Loma Linda University Electronic Theses, Dissertations & Projects

Expansion of the maxillae is a well recognized procedure in orthodontics. Little is known about Mandibular Expansion. This project is a pure research of the possibility of expanding the mandible laterally at the symphysis on a baboon.

The symphysis was cut A-P and expanded laterally 11 mm, then held and stabilized with a titanium mesh work screwed to the inferior border of the mandible. The defect area was filled with a bone graft of marrow and cancellous bone fragments taken from the greater trochanter and the crest of the ilium. New bone did fill in the defect and the expansion …

An Ultra-Violet Light Microscopic Study Of The Hydroxylapatite Ceramic-Bone Interface Phenomena, Leonard W. Pierce

Loma Linda University Electronic Theses, Dissertations & Projects

Preparations used in this study were obtained from an investigation which had undertaken the following:

Durapatite, a hydroxylapatite ceramic was implanted in 24 mature Beagle dogs to study its maintenance effect on the alveolar bone of the mandible.

After dividing the dogs into two groups, a fresh socket and a healed socket group, the posterior teeth were removed and alveolectomies were performed. Eight ceramic implants were then placed in the right mandible of each animal in each group. The healed group received the implants five weeks after tooth removal and the fresh socket group received implants immediately after extraction.

The …

Marginal Periodontium Changes In The Monkey (Macaca Nemestrina) Following Incisor Repositioning From A Mechanically Positioned Labioversion, Gary Engelking

Loma Linda University Electronic Theses, Dissertations & Projects

The anterior teeth of five adult pigtail monkeys were moved lingually to correct a previously induced labioversion. These teeth were retained in their more normal arch positions for five months, after which clinical and histologic measurements were made of the periodontium. The untreated cuspids served as controls. Measurements were made to record changes in the gingival margin, the mucogingival junction, the width of keratinized gingiva and the marginal bone level relative to a fixed point on the tooth crowns. Oxytetracycline was administered three times to label areas of osteogenesis in the periodontium.

The incisors were retracted a mean distance of …

Case Studies Of The Effects Of Orienting Stimuli On The Electroencephalogram And Levels Of Coma, Ina Muderspach, Marcia Swanson

Loma Linda University Electronic Theses, Dissertations & Projects

A comatose patient has long been a problem for nurses. Even though this problem has been recognized, very few studies have been conducted by the nursing profession to determine the best course of treatment for these patients. The physical care of the comatose patient has been dealt with in many nursing texts; in contrast, that portion of the care which the nurse could direct to the arousal of the comatose patient has not been documented.

The purpose of this study was to assess the effect of orienting stimuli on the individual level of consciousness as measured by Glasgow Coma Scale …

What's Happening: May 28, 1980, Maine Medical Center

What's Happening

No abstract provided.

The Involvement Of The Farm Animal Veterinarian In Animal Welfare, David G. Llewellyn

International Journal for the Study of Animal Problems

The following is excerpted from a paper presented by Mr. Llewellyn, BSc MRCVS at the British Veterinary Association Annual Congress, September 9-14, 1979, Aberdeen, Scotland.

Newsletter, Volume 25, Number 03, May - June 1980, John M. Daly Md, Edward M. Copeland Md, Stanley J. Dudrick Md, R. Bruce Bracken Md

Newsletter: A Report to Physicians of Texas Archives

• ACS Representative Explains New Cancer-Related Health Checkup Recommendations
• Intravenous Hyperalimentation Improves Immunocompetence in Cancer Patients, John M. Daly, MD, Edward M. Copeland, MD, and Stanley J. Dudrick, MD
• Computer Center Aids Researchers, Students
• Noteworthy
• Semen “Banking” No Solution for Many Patients, R. Bruce Bracken, MD, and Keith D. Smith, MD
• E.J. Freireich Named President of ASCO
• Brazilian Doctors Observer MDAH Treatment

Effects Of Relaxation Therapy On Anxiety In Depressed Clients, Patricia Anne Worret

Loma Linda University Electronic Theses, Dissertations & Projects

During a psychiatric field placement, it was noted by this nurse researcher that patients with a diagnosis of depression often overtly displayed symptoms of anxiety. A brief literature review revealed that this anxiety-depression duality occurred frequently.

The purpose of this study was to determine if relaxation therapy was a therapeutic intervention which could be utilized by nurses to provide relief from the symptoms of the anxiety-depression syndrome. This was a clinical, quasi-experimental research investigation. The sample was chosen by a purposive, non-random selection of 20 experimental and 10 control subjects who were hospitalized with a diagnosis of depression in an …

The Rate Of The Healing Process In Venous Thrombi Produced By A Sclerosing Agent With Special Attention To Endothelial Lining, Kiyoshi Tanaka

Loma Linda University Electronic Theses, Dissertations & Projects

Despite extensive clinical and experimental investigations of venous thrombosis, relatively little is known about the early phases of healing of the venous thrombus. Soon after its discovery heparin has become the most popular agent for the prevention and treatment of venous thrombosis, but there are a number of unanswered questions regarding the most satisfactory treatment for venous thrombosis.

One area of controversy has been the duration of anticoagulation therapy for acute venous thrombosis. If the anticoagulant is discontinued too soon, the thrombus may continue to propagate. Prolonged anticoagulant therapy exposes the patient to the risk of serious hemorrhage. The objective …

Noradrenergic Modulation Of Lateral Geniculate Neurons: Physiological And Pharmacological Studies, Michael Andrew Rogawski

Yale Medicine Thesis Digital Library

The physiological actions of norepinephrine (NE) were examined in the rat dorsal lateral geniculate nucleus (LGNd) using extracellular single cell recording and microiontophoresis. Prolonged, low current iontophoretic applications of NE consistently elicited an increase in the firing rate of LGNd neurons which was delayed in onset and prolonged after cessation of the ejection. Sympathomimetic amines other than NE also activated LGNd neurons with varying degrees of effectiveness. On the basis of the relative potencies of a series of these agonists and the ability of iontophoretically applied (alpha)-antagonists to selectively block the facilitatory action of NE, it is concluded that NE …

An Avoidance Response Bioassay For Aquatic Pollutants, Jeffrey A. Black, Wesley J. Birge

KWRRI Research Reports

Avoidance response bioassays were conducted with eight aquatic contaminants, including cadmium, copper, mercury, zinc, chloroform, dioctyl phthalate (DOP), trisodium nitrilotriacetic acid (NTA), and phenol. Tests were performed in a dual-channel fluviarium system, and the toxicant injection procedure used provided good regulation of exposure concentrations. Juvenile stages of largemouth bass (Micropterus salmoides), bluegill sunfish (Lepomis macrochirus), and rainbow trout (Salmo gairdneri), and tadpoles of the American toad (Bufo americanus) proved to be suitable animals for evaluating avoidance or attraction responses. The trout was the most sensitive species tested.

Avoidance was significant in tests …

Public Health And Public Wealth: Social Costs As A Basis For Restrictive Policies, David T. Courtwright

History Faculty Research and Scholarship

Historically, the most important rationale for coercive public health measures has been the prevention of disease and injury to others. However, as noncommunicable diseases and accidents have assumed increased importance as causes of morbidity and mortality, and as the connection between noncommunicable diseases and accidents and individual practices such as smoking and drinking has become more apparent, a new line of argument based on social costs has emerged. My purpose is both to describe and evaluate the social-costs argument, to explain why it has become so popular, and to show what must be done to make it consistent with its …

Glucocorticoid Receptors In Liver Cytosol Of Adrenalectomized Diabetic And Nondiabetic Chinese Hamsters, Richard E. Gibson

Masters Theses

The binding characteristics of glucocorticoid receptors in the liver cytosol of Chinese hamsters of the BE, BD (diabetic), and AV (nondiabetic) lines were studied and compared using a charcoal adsorption technique and ³H-dexamethasone. High affinity receptors(K_d ≃ 3 x 10^-9 M) were found with concentrations of 180 fmoles/mg protein in the nondiabetic and 260 fmoles/mg protein in the diabetic hamsters. Behavior of the receptor-steroid complex in 5 to 20% sucrose gradients of low and high salt concentrations (0.0 and 0.3 M KCl) and the competitive binding of other steroids were consistent with findings for rat liver glucocorticoid …