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Synthesis Of Mesoionic Nucleosides As Potential Antineoplastic Agents, Shanaz Mohammedali Tejani

Theses and Dissertations

During the past few decades, analogs of purine nucleosides have been described that are modified either in the heterocyclic base, sugar moiety or both, and many of these modified nucleosides display antiviral and/or antineoplastic activity. The Class II mesoionic purinones are isosteric with their non~mesoionic purinone counterparts. It is conceivable that the mesoionic purinone nucleosides might constitute an entirely novel class of modified nucleosides with potential chemotherapeutic activity. That the mesoionic heterobases are bioisosteric as well as isosteric with non-mesoionic purinones was realized by demonstrating that certain mesoionic xanthine derivatives, such as Anhydro-8-ethylw-5-hydroxy-7-oxo-l,3,4-thiadiazolo[3,2-a]pyrimidinium hydroxide and Anhydro-6-p-chlorobenzyl-8-ethyl-5-hydroxy-7-oxo—l,3,4—thiadiazolo [3,2-a]pyrimidinium hydroxide were comparable …

Cenobium 1983, Louisiana State University And Agricultural And Mechanical College, School Of Veterinary Medicine, Mica Landry, Jerry M. Law

Cenobium Yearbook

Cenobium began publication in 1977 and continued through 1990. Produced by students, the yearbooks are a chronicle of the daily life and the special events experienced by veterinary students at the LSU School of Veterinary Medicine.

Assertiveness Training With Mildly Mentally Retarded Institutionalized Persons, David Larry Bokor

Masters Theses

Assertiveness training is a psychological intervention strategy designed to develop the skills of individuals who fail to defend and express their rights, feelings, or beliefs in a straightfoward manner.

Currently there is no set procedure regarding the composition of assertiveness training when modified to suit the needs of various populations. However a vast majority of professionals do employ effective basic techniques, i.e. behavior rehearsal, coaching, feedback, and social reinforcement to shape assertive request and refusal behavior.

Low intelligence limits the mentally retarded person's ability to cope with emotional difficulties. Individuals that recognize their limitations often experience feelings of inadequacy, frustration, …

Pharmacokinetics And Protein Binding Of Morphine In Horses, Joan Combie, Thomas E. Nugent, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Morphine could be detected in horses dosed with 0.1 mg of drug/kg of body weight for up to 48 hours in blood and 144 hours in urine. This dose of morphine elicited no observ­able effects and is a suggested an­algesic dose. Computer analysis revealed that a 3-compartment open system was the best fitting model with a serum half life of 87.9 minutes and a urine half life of 101.1 minutes. Binding to equine serum proteins was linear over a drug con­centration range of 3.88 x 10-5M to 3.50 x 10-aM and averaged 31.6%. In RBC-partitioning experiments, 78.1 % of the …

La Coopérative De Markala: Une Nouvelle Approche Des Rôles Economiques Traditionnaux, Susan Daughman, Mariam N'Diaye Thiam

Poverty, Gender, and Youth

Ce numéro de SEEDS présente la cooperative de Markala, née de la détermination d'un groupe de femmes pauvres de la campagne Malienne à trouver un travail rémunerateur. Quand les vingt membres originaux s'associèrent en 1975, leur but était de gagner un salaire et d'apprendre des techniques reconnues et negociable sur le marché de l'emploi. En 1981, elles gèrent avec succès une cooperative qui produit et vend des pièces d'étoffe teintes et du savon de lessive. L'expérience des femmes de Markala a déjà aidé à la création d'autres coopératives dans la campagne Malienne. Cela démontre également que le fait de créer …

Oncolog, Volume 28, Number 01, January-March 1983, The University Of Texas Md Anderson Cancer Center, James M. Bowen Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Newsletter Becomes OncoLog
• Prolactinoma, a Prevalent Gonadoinhibitory Tumor, Responds Well to Treatment
• Laboratory Research Continues to Advance Methods of Cancer Diagnosis and Therapy
• Radiotherapy Plays Vital Role in Treatment or Patients with Malignant Parolld Tumors

The Working Women's Forum: Organizing For Credit And Change, Marty Chen

Poverty, Gender, and Youth

This issue of SEEDs tells the story of how the Working Women's Forum came into being in Madras, India and how it has brought together more than 13,000 poor, urban women around the issue of credit. It also describes how the Forum has not only provided its members with access to funds, but has expanded to include support services such as child care, education, health, and family planning and how the sense of strength and purpose that has grown up among the members is helping them to tackle the political and social problems that affect their lives.

Intimations Of Immorality: Clones, Cyrons And The Law, George P. Smith Ii

Scholarly Articles

This article examines some legal and moral issues associated with two developing areas of biomedicine; cloning and cryonics. The author firstly considers the practical benefits to society of developing perfecting and utilizing the process of cloning. These include the ability to overcome inheritable genetic defects and the provision of organs for transplantation. Against this must be weighed some moral and ethical problems of genetic engineering. Professor Smith then discusses the process of deep-freezing a person and the development of cryonics as a social movement. The major legal problem stemming from cryonics is determining the time at which a cryonically suspended …

Serial Cardiovascular Adaptations During Pregnancy, Mark Vincent Hart

Dissertations and Theses

Maternal cardiovascular adaptations appear to be essential in order to supply extra circulation to both the developing fetus and maternal system during a successful pregnancy. Since inadequate cardiovascular adjustments may produce abortions or maternal morbidity, the characterization of maternal cardiovascular changes during pregnancy and the elaboration of the underlying mechanism for these changes are essential to the understanding of how the heart enlarges during pregnancy and what significance this enlargement might have. To provide needed information regarding this time course and extent of maternal cardiac enlargement and the hormonal and hemodynamic changes which may be responsible for these changes, the …

Outlook Magazine, Spring 1983

Outlook Magazine

No abstract provided.

Outlook Magazine, Summer 1983

Outlook Magazine

No abstract provided.

J Am Coll Dent 1983 50 4

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

Gene Locus For Α₁-Antitrypsin (Pi) Assigned To Human Chromosome 14, Stephen J. Pearson

Yale Medicine Thesis Digital Library

No abstract provided.

The Utilization Of Response Surface Techniques In Survival Experiments, Leonard Edward Buchner

MUSC Theses and Dissertations

Linear regression procedures are described which give an unbiased estimate of the percent functional viability of rat polymorphonuclear leukocytes (PMN's). These statistical techniques allow discrimination between variables which result in increased PMN survival after freezing. A review of current response surface techniques was made as they relate to optimizing the functional viability of PMN's after freezing. Experimental designs based on the steepest ascent and simplex methodologies were considered. Since the hill climbing efficiency of the steepest ascent and simplex methods are comparable, the steepest ascent procedure was selected as it is more readily adaptable to a batch mode analysis.

An Investigation Into The Cellular And Humoral Organization Of The Thymic Microenvironment, Howard R. Higley

Dissertations

No abstract provided.

A Comparative Study Of Value Orientations In American Society, Mexican Society, And High School Students, Stanley A. Sliwiak

Dissertations

No abstract provided.

Virginia Dental Journal (Vol. 60, No. 1, 1983)

Virginia Dental Journal

No abstract provided.

Toxic Ferns Of Western Australia, T E H Aplin, P Steele, M C. Nottle

Technical Bulletins

Botanical descriptions and notes on the distribution of six species of ferns are given. These plants contain the enzyme thiaminase, which may induce thiamin deficiency, or other constituents toxic to animals. The clinical signs of both thiamin deficiency and fern toxicity in affected livestock are described.

Barley Foliage Diseases, T N. Khan, K. Brain, M Judges

Experimental Summaries - Plant Research

General comments and highlights

Scald: Effect of time of application - 83BA10, 83MT9.

Scald: Effect of rate of fungicide – 83BA11.

Scald: Comparing fungicides – 83BA42.

Scald: Effect of seeding rate – 83BA12, 83MT10.

Scald: Response to fungicide in farmer's field – 83AL18, 83AL81, 83AL82.

Scald: Variation in pathogenicity – 83AB11, 83BA13, 83MT11, 83WH7.

Scald: Cultivar x fungicide in farmer's field – 83LG63.

Net Blotch: Potential yield losses – 83A15, 83BA15, 83WH6.

Net Blotch: Screening new fungicides – 83BA43.

Spot-type net blotch: Potential yield losses – 83C5.

Spot-type net blotch: Sources of resistance - Chapman Research Station, Nabawa.

Powdery mildew …

Expression Of A Streptococcus Mutans Glucosyltransferase Gene In Escherichia Coli, James P. Robeson, Raul G. Barletta, Roy Curtiss Iii

School of Veterinary and Biomedical Sciences: Faculty Publications

Chromosomal DNA from Streptococcus mutans strain UAB90 (serotype c) was cloned into Escherichia coli K-12. The clone bank was screened for any sucrosehydrolyzing activity by selection for growth on raffinose in the presence of isopropyl- β-D-thiogalactoside. A clone expressing an S. mutans glucosyltransferase was identified. The S. mutans DNA encoding this enzyme is a 1.73-kilobase fragment cloned into the HindIII site of plasmid pBR322. We designated the gene gtfA. The plasmid-encoded gtfA enzyme, a 55,000-molecular-weight protein, is synthesized at 40% the level of pBR322-encoded β-lactamase in E. coli minicells. Using sucrose as substrate, the gtfA enzyme catalyzes …

Namru-3 Translations Of Parasite Literature From Russian, French, Japanese, Etc. Into English (1915-1983) T1601-T1700, United States Naval Medical Research Unit Number Three, Cairo, Medical Zoology Department

United States Naval Medical Research Unit 3: Publications

T1603. TRANSLATION FROM RUSSIAN. SELIVANOV, Ya. M. and POLYAKOVA, A. N. (1981). Technic of preparing and producing experimental series of immunoglobulin erythrocytic polytype diagnosticums to certain arboviruses for the indirect hemagglutination test. Sborn. Trud. Inst. Virus. imeni D. I. Ivanovsky, Akad. Med. Nauk SSSR, pp. 145-151.

T1604. TRANSLATION FROM RUSSIAN. ROSLAYA, I. G., DEMENEV, V. A., PRYGOVA, A. I., ROSLYAKOV, G. E. and VERETA, L. A. (1981). Certain questions of ecology of tickborne encephalitis group viruses in the lower Pre-Amur'ye. Sborn. Trud. Inst. Virus. imeni D. I. Ivanovsky, Akad. Med. Nauk SSSR, pp. 90-94.

T1605. TRANSLATION FROM RUSSIAN. EMEL'YANOVA. N. …

United States Naval Medical Research Unit Number Three, Cairo, Egypt, Medical Zoology Department Translation List, Harry Hoogstraal

United States Naval Medical Research Unit 3: Publications

List of translations of medical parasitology and medical entomology papers prepared by the United States Naval Medical Research Unit Number 3 in Cairo, Egypt. The papers were translated from numerous languages, such as Russian (most were translated from Russian), Bulgarian, Chinese, Czech, Finnish, French, German, and Japanese, into English. The publication dates of the original papers ranged from about 1915 to 1983. Harry Hoogstraal translated some or all of the papers.

Enteric Infections In Stockton, California : With Special Reference To The Genus Campylobacter, Tom Edward Hathorn

University of the Pacific Theses and Dissertations

During the last two or three years, the three largest hospitals in Stockton (St. Joseph’s, Dameron and San Joaquin General Hospitals) have modified their procedures to include the search for Campylobacter. On the other hand, the incidence of Yersinia in California is unknown, as most clinical laboratories do not specifically culture for it. There have been only a few reports of Yersinia in this state (personal communication of Dennis Ferrero, Director of the San Joaquin County Public Health Laboratory). This study has a threefold purpose: to investigate the incidences of Campylobacter and Yersinia, especially in relation to the incidence of …

Evaluation Of Drug Information Retrieval Services For Selected Investigational Antineoplastic Agents, Ali Al-Hasan A Al-Hefzi

University of the Pacific Theses and Dissertations

The availability of drug information that is useful to clinicians is an important need for those responsible for medication use in patients. Physicians, pharmacists, nurses, and patients routinely require access to relevant information related to rational drug therapy. The need for rapid access to relevant information has become increasingly important as the science, technology, and specialization within health care expand. Because of this expansion the literature has increased not only in size but also in complexity.

The term drug information (e.g., used in drug information service, drug information center or drug information specialist) is defined as "knowledge of facts or …

Molecular And Serological Studies Of Recombinant Bluetongue Viruses., Jasbir Brar Kahlon

All ETDs from UAB

No abstract provided.

Jefferson Alumni Bulletin – Volume Xxxii, Number 2, Winter 1983

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XXXII, Number 2, Winter 1983 Jefferson Scene, Page 2 Endowments, Page 10 Third world involvement, Page 13 Class notes, Page 25

Book Review Of Genetics, Ethics, And The Law, Larry I. Palmer

Faculty Publications

No abstract provided.

A Nursing Intervention And The Cognitive Functioning And Comfort Of Family Members Of Critically Ill Patients., Dianne East Piazza

All ETDs from UAB

No abstract provided.

A Case Analysis Of The Legal, Professional, And Ethical Responsibilities Of Registered Nurses For Disclosure Of Prognostic Information To Dying Adults (Philosophy)., Maxine Blackmon Jones

All ETDs from UAB

No abstract provided.

A Proposed Mechanism For The Thermotropic Effects Of Pipradrol In The Rabbit, Stephen Franklyn Small

University of the Pacific Theses and Dissertations

In the present study, the influence of various drug pretreatments will be investigated in the rabbit in an attempt to (a) define the pharmacological mechanism of action of pipradrol in its mediation of hyperthermia and (b) observe the effects of these pretreatments on the behavioral effect of pipradrol. Although pipradrol is no longer of clinical utility, it is hoped that the results of this study may provide more information for its use in future studies as a pharmacological tool.