Digital Commons Network^™

What's Happening: June 13, 1984, Maine Medical Center

What's Happening

No abstract provided.

Influenza: Prevention And Therapy, William M. Valenti

Henry Ford Hospital Medical Journal

No abstract provided.

Immunology Of The Acquired Immunodeficiency Syndrome, Patrick W. Mclaughlin, Carl B. Lauter

Henry Ford Hospital Medical Journal

The Acquired Immunodeficiency Syndrome (AIDS) first recognized in 1981, has been extensively studied, and the most recent studies have demonstrated that its defects extend well beyond the apparent deficient cell-mediated immunity to include humoral immunity, autoimmunity, and abnormal immunoregulation. The recent discovery of a retrovirus, HTLV III, as a possible etiologic agent is discussed in relation to other viruses known to cause immunodeficiency. Simian AIDS, an animal model of virus-induced immunodeficiency, is also discussed. Recommendations are made regarding the interpretation and limitations of immune testing in AIDS, including a discussion of how apparently healthy homosexuals and groups at risk develop …

An Overview Of The Newer Antibiotics, Ramon Del Busto

Henry Ford Hospital Medical Journal

The introduction of a large number of new antibiotics has made selecting the one most appropriate for treatment a confusing task for the practicing physician. One problem is that the differences in pharmacokinetics, in vitro activity, and clinical indications between some of these agents may be relatively minor; this is especially true of the new cephalosporins. Another problem is that the generic names of the cephalosporins are so similar that it is impractical, even for the infectious diseases specialist, to be familiar with all of them. This review attempts to summarize the most important characteristics of these new antibiotics and …

Viral Hepatitis: Update On Prevention, Miriam J. Alter

Henry Ford Hospital Medical Journal

No abstract provided.

The Hsus Condemns Psychological Experimentation On Animals

Close Up Reports

For almost a century, millions of cats, dogs, monkeys, and other laboratory animals have fallen victim to the misguided notion that by torturing animals we may someday find the golden key that unlocks the dark corners and passageways of human psychology. Heedless of any relevance the experiments may have to the human condition or of the differences between humans and other animals, experimental psychologists are exercising unbridled on animals the whole range of suffering, from emotional trauma, like that experienced by the doomed infant monkey, to outright physical torture. Animals have been blinded and returned to the wild to test …

Santa Clara Magazine, Volume 26 Number 8, Summer 1984, Santa Clara University

Santa Clara Magazine

2 - ALBEE'S ST. GEORGE AND THE DRAGON By Michael Tueth, S.J. Some principles of archetypal criticism are applied to Albee's Who's Afraid of Virginia Woolf?

7 - NUCLEAR ADDICTION Edmund G. Brown Jr. The United States and the Soviet Union are engaged in an addictive and ultimately lethal process. Neither will break out of the curse of assured mutual destruction.

9 - GIVE US THIS DAY OUR DAILY BREAD By Charles E. French. There are good reasons today to hope for a solution to world hunger, one that will occur in our time.

13 - TRAITS OF A HEALTHY …

Prospects For The Medical Use Of Interferon In 1984, Bosko Postic, Julio C. Arroyo

Henry Ford Hospital Medical Journal

Interferon, a natural and wide spectrum antiviral polypeptide that was discovered in 1957, has been extensively described. In addition to its antiviral effect, interferon has been found to suppress tumor growth and modulate the immune response. Until 1980, interferon was primarily prepared for clinical trials in human leukocytes derived from the buffy coat of whole blood. A major breakthrough occurred in the late 1970s when human interferon was produced by DNA recombinant methods in such heterologous cells as bacteria (genetic engineering). Interferon is not commercially available in 1984, but it may, based on clinical trials in humans, become part of …

Rapidly Progressive Pancytopenia, Hepatomegaly, And Abnormal Lung Uptake Of Colloid In Systemic Lupus Erythematosus: Possible Saturation Of Reticuloendothelial System With Blood Elements, Tetsushi Sakurai, Kiyoshi Fukuda, Ichiro Kono, Teizo Kabashima, Kazuhide Yamane, Heihachiro Kashiwagi

Henry Ford Hospital Medical Journal

A patient with systemic lupus erythematosus developed severe abdominal pain and tender hepatomegaly associated with progressive pancytopenia and elevated serum levels of circulating immune complexes. Liver scintigram demonstrated extreme hepatomegaly with poor colloid uptake and splenomegaly with increased colloid uptake. An unusual accumulation of colloid in the lungs was also noted. Subsequent clinical and laboratory studies raised the possibility of saturation of the reticuloendothelial system in the liver by circulating immune complexes and blood cells, a condition demonstrated in experimental animals, but not hitherto well documented in the human immune complex disorder.

Clinical Trials: I. Design And Ethical Issues, Barbara Tilley

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

The Effects Of Maternal Administration Of Methadone On Beta-Endorphin Content In The Brain And Pituitary Of The Rat Progeny, Randall L. Braun

Loma Linda University Electronic Theses, Dissertations & Projects

Methadone is often used in the maintenance and detoxification of opioid-dependent pregnant women. This use of methadone during pregnancy is known to be associated with teratogenic effects observed in the progeny. The present study is an attempt to gain insight into possible pathophysiologic mechanism(s) responsible for these teratogenic effects: specifically, a relationship between maternal methadone administration and the content of the endogenous opioid peptide, beta-endorphin, in the brain and pituitary of the rat progeny.

In brief, nulliparous mature female Sprague-Dawley rats received daily injections (5 mg./kg.) of methadone hydrochloride (methadone-treated) or a similar volume of physiological saline (controls), treatment started …

The Effect Of Dietary Alpha - Linolenic Acid On Apparent Risk Factors Of Cardiovascular Disease, Kelvin D. Lindbeck

Loma Linda University Electronic Theses, Dissertations & Projects

Eight healthy male lacto-ovo-vegetarian subjects averaging 28.0 ± 3.6 years of age (22 to 53 years) were fed a diet rich in α-linolenic acid (18:3 ω 3) for four weeks. Arterial blood pressure and body weight were recorded each week. Plasma 6-keto-prostaglandin F_1α (6-keto- PGF_1α ), thromboxane B₂ (TXB₂), total cholesterol, triglyceride, and total phospholipid fatty acid composition were analyzed at 0, 2 and 4 weeks.

Systolic blood pressure increased significantly between weeks 0 and 1 (106.5 ± 2.7 mmHg to 114.0 ± 3.7 mmHg; p < 0.003), but decreased to 107.3 t 2.6 mrHg (p < 0.02) at week 2. There was an insignificant increase in both systolic and diastolic blood pressures after four weeks. There was no significant change in either total cholesterol or triglyceride levels during the four weeks.

Plasma 6-keto-PGF_1α levels increased significantly from 60.13 ± …

Lesions Induced In Rodent Pancreas By Azaserine And Other Pancreatic Carcinogens, Daniel S. Longnecker

Dartmouth Scholarship

Focal proliferative changes in the acinar cells of the pancreas of rats have been induced by several systemically administered carcinogens including azaserine, N-nitrosobis(2-oxopropyl)amine, N-nitroso-(2-hydroxypropyl) (2-oxopropyl)amine, and N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO). Foci, nodules, and adenomas induced by these carcinogens are usually made up of atypical-appearing acinar cells that maintain a high degree of differentiation, but a minority of these lesions exhibit anaplastic cellular changes that suggest the development of malignant potential. Such anaplasia may occupy the whole of smaller lesions or may occur as a secondary focal change within larger nodules or adenomas. Many foci and nodules per pancreas have been induced …

What's Happening: May 23, 1984, Maine Medical Center

What's Happening

No abstract provided.

Mrs. Regina Borum Interview (2) Conducted On May 16, 1984 About The Boonshoft School Of Medicine At Wright State University, Regina Borum, James St. Peter

Boonshoft School of Medicine Oral History Project

In this second interview, Mrs. Borum continues her description of responsibilities and duties, concentrating on her interactions with the press and organizations outside of the university. Mrs. Borum then turns to the development of the School of Medicine's Development Department, and her thoughts and recollections on key people in the School of Medicine's development.

Alteration Of Gallium Biodistribution Using Indium Complexes For Enhanced Early Imaging, John W. Triplett

Pharmaceutical Sciences Faculty Patents

Radiopharmaceutical compositions and methods for tumor tomography in mammals are disclosed, wherein radioactive gallium and non-radioactive indium are injected into said mammals whereby the affinity of said radioactive gallium for non-tumor tissues is decreased, resulting in enhanced imaging characteristics.

Richard Dewall Interview Conducted On May 5, 1984 About The Boonshoft School Of Medicine At Wright State University, Richard Dewall, James St. Peter

Boonshoft School of Medicine Oral History Project

This interview is with Dr. Richard DeWall, a prominent Dayton Cardio-thoracic surgeon. In this first interview Dr. DeWall discusses his background prior to coming to the Dayton area and his initial activities in the Cox Heart Institute and Kettering Memorial Hospital. He then goes on to describe how he first became interested in a school of medicine in Dayton, how he focused on Wright State University as the location for that school of medicine and his initial contacts with community and Wright State University leaders in which he lobbied for the school.

In the second part of this interview, Dr. …

อิทธิพลของประสาทซิมพาเธติคต่อต่อมน้ำลายสับแมนดิบูลาร์และเมเจอร์สับลิงกวล : ตอนที่ 2 ส่วนประกอบของเนื้อเยื่อภายในต่อม, นวลน้อย เวชบรรจง, จุติศรี แสงวิเชียร, สิริมา สุตรา, วิวัฒน์ ศิริกุล, มาโนช ชัยวัฒน์, ดอลลี่ เมธาธราธิป, วันดี อภิณหสมิต

Chulalongkorn University Dental Journal

ภายหลังการผ่าตัดเอา superior cervical ganglion ทางด้านขวาของหนู (mouse) ออกเป็นเวลา 3 เดือนมีผลทําให้จํานวนของ acini ใน submandibular salivary gland ลดลงเนื่องจากขาด sympathetic nerve มาเลี้ยง ในขณะเดียวกันต่อมน้ำลายได้สร้าง granular ducts เพิ่มขึ้นเป็นจํานวนมากเพื่อช่วยผลิตน้ำลายขึ้นมาชดเชยกับปริมาณน้ำลาย ซึ่งลดลงจากการที่ acini ฝ่อไป การเพิ่มจํานวนขึ้นอย่างรวดเร็วของ granular ducts ทําให้ไปเบียดที่อยู่ของ stroma ดังนั้นจํานวนของ stroma จึงลดลงอย่างมีนัยสําคัญทางสถิติ (P < 0.03) ไม่มีการเปลี่ยนแปลงทางจุลกายวิภาคศาสตร์หรือจำนวนส่วนประกอบของ major sublingual salivary gland อย่างเห็นได้ชัดเมื่อเปรียบเทียบระหว่างกลุ่มทดลอง(experi-mental animals) และกลุ่มเปรียบเทียบ(sham-operated animals)

Protein Recovery And Coagulation Properties Of Commercial And Fractionated Milk Clotting Enzymes, Khalida A. Shaker

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Protein recovery and coagulation properties of five commercial and fractionated milk clotting enzymes were studied. The fractionated enzymes were Sephadex G-100 fractions of the commercial enzymes. Milk clotting activity of each fraction was tested using Berridge substrate. All fractions from each preparation which had milk clotting activity as measured with the Formagraph were collected and pooled. These samples and the original enzyme preparations were used to coagulate milk. Percent of protein lost in whey was determined by Kjeldahl. Coagulation was followed using a spectrophotometer monitoring changes in apparent absorbance at 600 nm. Curd protein yields using the five original enzyme …

Inhibition Of Growth Of Toxoplasma Gondii In Cultured Fibroblasts By Human Recombinant Gamma Interferon., E. R. Pfefferkorn, Paul M. Guyre

Dartmouth Scholarship

The growth of Toxoplasma gondii in cultured human fibroblasts was inhibited by recombinant human gamma interferon at concentrations of 8 to 16 U/ml. The interferon was titrated by observing a total inhibition of parasite plaque formation 7 days after infection. Inhibition of the growth of T. gondii in the early days after infection was measured by marked reductions in the incorporation of radioactive uracil, a precursor that can only be used by the parasites. This assay showed that when cells were pretreated with gamma interferon for 1 day and then infected, inhibition of T. gondii growth could be readily detected …

Evaluation And Improvement Of Coagulation Properties Of Milk For Manufacturing, Leslie M. Okigbo

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A rugged and sensitive instrument "Vatimer" was developed to evaluate the coagulation properties of milk in cheese vats. Microvolt signals from the instrument varied with standing-wave motion of milk, forces arising from coagulation, curd firming, curd syneresis and also clean-in-place spray forces. Curd firmness at cutting varied three to four fold in commercial Cheddar cheesemaking operations.

The Formagraph instrument was used to select individual cow milk samples with good and poor chymosin-coagulation characteristics from the Utah State University Holstein herd. Blending 50% good-, and 50% poor-coagulating samples did not improve average coagulation properties of poor samples. Higher chymosin concentration caused …

Detailed Description And Nomenclature Of High Resolution G-Banded Horse Chromosomes And Cytogenetic Analysis Of Hereditary Multiple Exostosis In Horses, Alma Maciulis

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A reliable technique for obtaining late prophase, prometaphase and greater numbers of metaphase chromosomes is presented. The increased number of mitoses and high resolution chromosomes were obtained using a modification of the typical three-day blood culture technique in which the cell cycle was temporarily blocked at the G₁-s border with methotrexate. A high resolution G-band idiogram is presented using a system similar to the standardization of human chromosomes. The use of this technique and system of nomenclature will facilitate routine analyses of horse chromosomes and provide a basis for the identification and recording of chromosome aberrations in this …

Distribution Of The Shoshone Scuplin (Cottus Greenei: Cottidae) In The Hagerman Valley Of South Central Idaho, Richard L. Wallace, J. S. Griffith Jr., D. M. Daley, Patrick J. Connolly, G. B. Beckham

Great Basin Naturalist

Cottus greenei, a potentially threatened species endemic to Idaho, was collected from 49 localities in 25 springs/streams in south central Idaho. Most localities were along the north bank of the Snake River in waters of the Thousand Springs formation, Gooding County. One population was found in a spring in the main Snake River. Another sculpin, Cottus bairdi, was collected with C. greenei at 23 locations in 16 springs/streams. Confusion concerning the type locality of Cottus greenei is discussed.>

What's Happening: April 18, 1984, Maine Medical Center

What's Happening

No abstract provided.

The Impact Of Modernization On The Aged In American Samoa, Ellen C. Rhoads

Pacific Studies

No abstract provided.

Vital Signs, Spring 1984, Boonshoft School Of Medicine

Vital Signs

A twenty eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

The Problem Of Reductionism In Theories Of Hemispheric Specialization And Recovery Of Functions, Grant Jackson Butterbaugh

Masters Theses

A selective review of functional and anatomical hemispheric asymmetries in humans confirms the doctrine of hemispheric specialization. However, the post-insult phenomenon of recovery of functions challenges theories that posit too strict a correspondence between anatomical structures and functions. Follow-up studies on hemispherectomized and hemidecorticated patients, who later recovered language, support a hypothesis of hemispheric redundancy, rather than "invariant" hemispheric specialization for language. Thus, through an evolutionary selection process, the brain may have developed as two potentially similar organs. Neuropsychological research on recovery phenomena is criticized as neglecting environmental contributions to recovery. Several models of hemispheric specialization are compared with recovery …

Investigation Of The Coenzyme Binding Site Of Lactate Dehydrogenase From Chicken Muscle, Jia-Hwei Lin

Chemistry & Biochemistry Theses & Dissertations

Investigation of the coenzyme binding site of lactate dehydrogenase was approached by using coenzyme analogs. Inhibition studies of this enzyme using n-alkylphosphates as coenzyme analogs were performed with a fluorometric method. The results showed that all of the n-alkylphosphates were competitive inhibitors with respect to NAD⁺.

The n-alkyl-ADPs were synthesized from AMP and dicycloheaylammonium salts of n-alkylphosphates. The synthetic compounds were subjected to NMR spectroscopic studies, thin layer chromatography and determination of the ratio of adenosine moiety to phosphate groups. The results indicated that the synthetic compounds were n-alkyl-ADPs.

These synthetic compounds were used as coenzyme analogs in …

Robert Stuhlman Interview (1) Conducted On March 27 1984 About The Boonshoft School Of Medicine At Wright State University, Robert Stuhlman, James St. Peter

Boonshoft School of Medicine Oral History Project

This is the first of two interviews with Dr. Robert Stuhlman. Dr. Stuhlman is the Director of the Laboratory Animal Resources and is the Director of the Interdisciplinary Teaching Laboratories in the Wright State University School of Medicine. In this interview, Dr. Stuhlman discusses the initial organization and development of both programs and the problems encountered in the various moves made by Dr. Stuhlman and his staff.

Dr. Stuhlman also discusses the development of the staffs for the two sections within the School of Medicine and the philosophies under which they have grown during his tenure as director. Finally, Dr. …