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Ethical Aspects Of Animal Experimentation, Wolfgang Scharmann

Experimentation Collection

If inquiries are made of people regarding their attitudes towards animal experimentation, there will no doubt be various answers corresponding to the different ethical attitudes today. Three principle points of view are imaginable. The two extremes are: an unrestricted support of all animal experiments; and a radical rejection of any such experiment. These two positions, in all likelihood, are taken by only a minority of the population. The majority will approve of animal experimentation in principle, however, only insofar as it is really necessary to preserve human life. So, the point of controversy arises from the question: When is an …

Alternatives To Aversive Procedures With Animals In The Psychology Teaching Setting, Jeffrey A. Kelly

Experimentation Collection

In this paper, we will consider the treatment of laboratory animals in psychology instruction and will focus on practical alternatives to traditional practices that cause pain and distress to animals. While the discussion will draw on psychology for examples, many of the issues apply equally to the instruction of students in other courses of study, including medicine, veterinary medicine, biology, and physiology.

Three Blind Mice, See How They Run: A Critique Of Behavioral Research With Animals, Michael A. Giannelli

Experimentation Collection

Animal research has been a traditionally accepted and respected part of modern psychology from its earliest days. The prevalent view of animals in contemporary psychology has origins far more basic than the scientific method. Its roots are deeply imbedded in Judaeo-Christian culture, a tradition which postulates a wide gulf between humankind and the animal world. The Darwinian revolution and the ethological outlook it fostered, while of immense biological significance, has for the most part been neglected by modern American comparative psychologists in favor of a positivistic-behaviorist orientation with a heavy reliance upon laboratory experimentation.

In recent years, opposition to animal …

Anthropomorphism Is Not A Four-Letter Word, Randall Lockwood

Experimentation Collection

Most animal scientists are directly or indirectly instructed to avoid any hint of anthropomorphism, yet it is an approach that is invariably applied by scientists and lay people alike. Science may have gained some objectivity in discarding this common view of animals, but it has gone overboard in its rejection of the concept of the continuity of human and animal experiences. I hope to outline how an anthropomorphic perspective can be applied in ways that are a service to science and the animals themselves.

The Imbalance Between Experiment And Theory In Biology: The Need For Theory-Directed Modeling, M. L. Fidelman, D. C. Mikulecky

Experimentation Collection

In biological and biomedical research, the vast majority of resources are focused on conducting experiments. Most of these experiments utilize animals. Only a tiny amount of resources is spent on theory and modeling. It is our contention and the basic theme of this paper that the imbalance between theory and experiment in biology produces very poor science. The implications of which are that many of the experiments conducted have little real scientific meaning or value and, therefore, go hand-in-hand with unnecessary animal use and suffering. Given the finite resources available for research, the redirection of significant resources from an almost …

Veterinary Conduct And Animal Welfare, H. Rozemond

Veterinary Science and Medicine Collection

This paper is a lecture presented to the same Association but fifteen years later: the 131st Annual Congress in 1984. This second presentation contemplates two points: First, it tries to indicate how this criticism has gradually emerged and a historical outline is put forth of the development of veterinary medicine, a differentiation being made between a mythical, a technical, and a critical approach. Second, a discussion of how veterinarians have to associate themselves with this criticism in their professional conduct is presented. This discussion is necessary for two reasons. Veterinarians have increasingly become aware that they bear a professional responsibility …

To Write A Theriatric Oath, Gretchen Lockwood

Veterinary Science and Medicine Collection

The Veterinarian's Oath was a disappointment to me. When I first read it as a freshman, I suppose I was expecting something along the lines of the Hippocratic Oath; instead I was struck by the contrast to it-by the lack of eloquence, of poetry, of ancient power. As impressionable as I was then, a whole year and a half ago, it left me unmoved. Now, having had my eyes opened to its more troubling ethical difficulties, I feel the desire to create something better, something that is at least more meaningful to me. As an individual, particularly without extensive dialogue …

T-61 Use In The Euthanasia Of Domestic Animals: A Survey, Andrew N. Rowan

Veterinary Science and Medicine Collection

A variety of techniques have been proposed and employed for the killing of domestic animals but relatively few have survived as suitable agents for euthanasia-namely, the induction of painless, suffering-free death. Some agents, such as strychnine, curariform agents, or potassium salts cause suffering while others have other disadvantages. 'lbday, dogs and cats are commonly euthanatized with sodium pentobarbital or with T-61 which is a mixture of a central nervous system narcotic, a paralytic agent, and a local anesthetic. The use of T-61 was first reported in the United States in 1963 (Quin 1963). The substance gradually became more popular because …

Applications Of Laboratory Technology In The Evaluation Of The Risk Of Rabies Transmissions By Biting Dogs And Cats, Donald C. Blenden, Manuel J. Torres-Anjel, F. T. Satalowich

Veterinary Science and Medicine Collection

While rabies is not a common disease in domestic animal species of the United States, potential exposures to rabies in the form of bites are very common and increasing. A nationwide study conducted among general hospitals shows that 1 percent of emergency room visits are for animal bites, of which 80-90 percent are inflicted by the dog (Callaham 1980). This figure is conservative, as the study did not include pediatric hospitals, the bite of victims that progress only to a physician's office, or those that receive no medical care at all. In Missouri alone, this study would infer about 1500 …

Santa Clara Magazine, Volume 27 Number 3, Winter 1985, Santa Clara University

Santa Clara Magazine

2 - WHEN ARE LEADERS AT THEIR BEST? By James M. Kouzes and Barry Z. Posner. There is a revolution in leadership style taking place in corporate America. This deals with how ordinary people get extraordinary things done in organizations.

7 - A MEDITATION IN ST. IVES By William J. Rewak, S.J. Some reflections on the essence of work taken from Father Rewak's travel diary during a trip to England last summer.

10 - TAKING LAUGHTER SERIOUSLY By John Morreall. A philosophy professor shows how important humor is to human life and how understanding our laughter can help us understand …

Uwomj Volume 54, Number 3, March 1985, Western University

University of Western Ontario Medical Journal

Schulich School of Medicine & Dentistry

Virginia Dental Journal (Vol. 62, No. 2, 1985)

Virginia Dental Journal

No abstract provided.

Characterization Of Monoclonal Antibodies Against Shiga-Like Toxin From Escherichia Coli, Nancy A. Strockbine, Lilian R. M. Marques, Randall K. Holmes, Alison D. O'Brien

United States Public Health Resources

Three monoclonal antibodies, designated MAb 16E6, MAb 13C4, and MAb 19G8, were produced which recognize Shiga-like toxin (SLT) from Escherichia coli. All three monoclonal antibodies neutralized the cytotoxicity of E. coli SLT and were able to immunoprecipitate intact labeled toxin with Staphylococcus aureus protein A. The three antibodies were of the Gl heavy and kappa light chain classes. MAb 16E6 bound to the B subunit of SLT in Western blots and also neutralized the lethality of the toxin for mice and the enterotoxicity of the toxin in ligated rabbit ileal loops. The ability of MAb 16E6 to neutralize the …

Protein Concentration Elevations In Mouse Lungs Following Sudden Transient Cephalad (+Gz) Acceleration, Charles J. Gutierrez

Retrospective Theses and Dissertations

Laboratory and feral lineages of mice were subjected to cephalad (+G_Z) accelerations, for 1.8 seconds, aboard a solid fuel rocket. Spectrophotometric analysis of bronchoalveolar lavage retrieved post launch revealed significant (p < .001) elevations of protein in the lungs of experimental mice. Sudden transient imposition of a mean +G_Z acceleration of 6.22 ± .47 (SD) G, at lift-off, may have induced hypervolemia of basilar pulmonary microvasculature with concomitant migration of fluid and protein from intravascular to juxta-alveolar perivascular compartments. Exudates may have entered bronchiolar airways subsequently gravitating toward alveoli.

Qualitative And Quantitative Morphology Of Lateral Rectus Motoneurons Of The Principal Abducens Nucleus, Helen Russell-Mergenthal

Theses and Dissertations

Nine lateral rectus motoneurons of the principal abducens nucleus, intracellularly stained with HRP, were morphometrically analyzed by light microscopy using a new method for determining motoneuron size. Particular emphasis was placed on devising a method of estimating total dendrite size from the proximal dendritic diameter alone.

The dendrites of these cells were divided into three types. One type, the microdendrites, had a consistent diameter of l micrometer, variable but short lengths, and added very little to the overall cell size. The majority of the dendrites on these cells (83) were standard in appearance but they could be separated into two …

Genetics, Eugenics, And Public Policy, George P. Smith Ii

Scholarly Articles

No abstract provided.

Ms079: Imarch 1985 Biography Information- Mylie E. Durham Jr., Md, Mylie E. Durham Jr (1919-1991)

Mylie E. Durham, Jr., MD Papers

These documents are biographical information in relations to early life, education, and professional activities. See more at Mylie E. Durham, Jr., MD Papersand its finding aid.

Ms079: Iharris County Medical Society Ellen Durckel Interviewing Dr. Mylie E. Durham, Jr. (Continued), Mylie E. Durham Jr (1919-1991)

Mylie E. Durham, Jr., MD Papers

In this Q&A, he discusses his early career, his medical focuses on military history, second marriage, his work in Houston, his relationship with George Herman, and how the medical field has become colder and more professional before. See more at Mylie E. Durham, Jr., MD Papersand its finding aid.

An Anatomical And Physiological Investigation Of The Infralimbic Region Of The Rat Medial Frontal Cortex, Robert T. Terreberry

Dissertations

No abstract provided.

The Neuroanatomical Connections And Somatotopic Organization Of The Posterior Nuclear Complex Of The Rat Thalamus, E. Luke Bold

Dissertations

No abstract provided.

Electrophysiologic Study Of The Effect Of Phospholipase-C (Clostridium Welchii-Type) On Neuromuscular Transmission In The Mouse, Lukasz M. Konopka-Egan

Dissertations

No abstract provided.

Lectin-Mediated Effects On Bone Resorption In Vitro: A Morphological And Functional Study, Steven N. Popoff

Dissertations

No abstract provided.

The Effects Of In Utero Chlordecone Exposure On Receptor-Coupled Phosphatidylinositol Turnover In Developing Rat Brain, Kristine D. Dahl

Dissertations

No abstract provided.

The Role Of The Insulin Receptor In Skeletal Muscle Insulin Resistance: Evaluation Of Two Animal Models, Charles F. Burant

MUSC Theses and Dissertations

The role of the insulin receptor in muscle insulin resistance was studied. Denervation of skeletal muscle resulted in the rapid appearance of a decrease in basal and insulin stimulated glucose transport, glycogen synthesis and a defect in the activation of glycogen synthase which was independent of levels of glycogen in the muscle. The effect was seen in both predominantly red and predominantly white muscle. There was no change in the denervated muscles' sensitivity to epinephrine-mediated decrease in glycogen synthesis or glycogen content, nor was there a major change in the insulin binding capacity of denervated muscles. A technique was developed …

Vital Signs, Winter 1985, Boonshoft School Of Medicine

Vital Signs

A twenty seven page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Cenobium 1985, Louisiana State University And Agricultural And Mechanical College, School Of Veterinary Medicine, P. K. Hendrix, Laura Hokett

Cenobium Yearbook

Cenobium began publication in 1977 and continued through 1990. Produced by students, the yearbooks are a chronicle of the daily life and the special events experienced by veterinary students at the LSU School of Veterinary Medicine.

Update - Winter 1985, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Hastings Center and Ethics Center to present "Biomedical Ethics Today: Old models and New" at Loma Linda April 21 and 22
-- Maloney and Winslow address allocation
-- "Worship Aids" unite ethics and liturgy
-- Ethics Center: Priest, Prophet, or Participant? (Editorial)

[ Reflections Regarding William Bartling ]
-- Siding With Life
-- The Patient is the Final Arbiter
-- Competing Claims Make Hard Choices

-- Excerpts from the California appeals court decision
-- $200,000 given to Ethics Center

Anterior Communicating Artery Aneurysm And Vasospasm – A Computer Model [Poster Boards], G. Austin, R. Gaskell

The Dr. George M. Austin Neurology Research Collection

Poster presentation boards for “Anterior Communicating Artery Aneurysm and Vasospasm – A Computer Model,” G. Austin and R. Gaskell – Storke [sic] Research Foundation, Santa Barbara, Ca. and Dept. of Neurosurgery, Univ. of S. Cal., L.A., 5 p.

Evaluation Of Analytical, Pharmacokinetic And Pharmacodynamic Methods For The Study Of Digoxin, Santosh John Vetticaden

Theses and Dissertations

The primary objective of the research was to investigate the pharmacodynamics of digoxin in dogs. Initially an assay specific for digoxin in the presence of its major metabolites, viz., digoxigenin, digoxigenin mono-digitoxoside, digoxigenin bis-digitoxoside and dihydrodigoxin was developed using HPLC-RIA. Methodology for non-invasive measurement of left ventricular ejection time (LVET) and other systolic time intervals (STI) in beagle dogs were developed. This involved surgery for exteriorization of the carotid artery in the dogs and subsequent measurements of LVET and STI after recovery. STI, heart rate (HR) and digoxin levels were monitored in normal beagle dogs administered 0.05 mg/kg or 0.025 …

Oncolog, Volume 30, Number 01, January-March 1985, Jordan U. Gutterman Md, Edwin C. Murphy, Jr. Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Investigators Explore Role of Oncogenes in Normal Growth and Carcinogenesis
• Lung Cancer Surpasses Breast Cancer as Mortality Risk to Texas Women
• New NCI Data Base Offers Physicians Up-to-Date Cancer Treatment Information