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Virtue And The Health Professions, Janet Pisaneschi

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society, February 8, 1991.

Update - May 1991, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Strategies for Moral Decision-Making: Confessions of a Moral Underling

[ The HIV Status of Health Professionals: Do Patients Have a Right to Know? ]
-- Risk Transmission of HIV form Infected Clinician to Susceptible Patients
-- Does the Patient Have a Right to Know the HIV Status of the Health-Care Worker?
-- Health-Care Professionals With Aids: A Patient's Right to Know?

Reaction Of Chromium(Vi) With Glutathione Or With Hydrogen Peroxide: Identification Of Reactive Intermediates And Their Role In Chromium(Vi)-Induced Dna Damage, J Aiyar, H Berkovits, R Floyd, K Wetterhahn

Dartmouth Scholarship

The types of reactive intermediates generated upon reduction of chromium(VI) by glutathione or hydrogen peroxide and the resulting DNA damage have been determined. In vitro, reaction of chromium(VI) with glutathione led to formation of two chromium(V) complexes and the glutathione thiyl radical. When chromium(VI) was reacted with DNA in the presence of glutathione, chromium-DNA adducts were obtained, with no DNA strand breakage. The level of chromium-DNA adduct formation correlated with chromium(V) formation. Reaction of chromium(VI) with hydrogen peroxide led to formation of hydroxyl radical. No chromium(V) was detectable at 24 degrees C (297 K); however, low levels of the tetraperoxochromium(V) …

Evidence For Attenuation Of Myo-Inositol Uptake, Phosphoinositide Turnover And Inositol Phosphate Production In Aortic Vasculature Of Rats During Pregnancy, Kirk P. Conrad, Susan A. Barrera, Peter A. Friedman, Vicki M. Schmidt

Dartmouth Scholarship

We postulated that vascular phosphoinositide metabolism is attenuated during pregnancy, and thereby could contribute to maternal vasodilation and reduced vascular reactivity. The basal rate of incorporation of [3H]myo-inositol and [3H]glycerol into phosphoinositides of aortae from pregnant rats in vitro was significantly reduced, when compared with vessels from virgin animals. After injection of [3H]myo-inositol intravenously into chronically instrumented conscious pregnant and virgin rats, the incorporation of the label by phosphatidylinositol was 66 +/- 4% less in aortae of gravid versus virgin animals (P less than 0.001), despite comparable plasma concentrations of radioactivity. Fold stimulation of total [3H]inositol phosphates by arginine vasopressin, …

Novel Peptidyl Carbamate Inhibitors Of The Enzyme Elastase, George A. Digenis, Bushra J. Agha

Pharmaceutical Sciences Faculty Patents

To see the abstract, please download this patent.

The Gamut: A Journal Of Ideas And Information, No. 32, Spring 1991, Cleveland State University

The Gamut Archives

CONTENTS OF ISSUE NO. 32, SPRING, 1991

Editorial

Louis T. Milic: The Cynic’s New Word Book, 2

Jane Ware: The Bones of Fort Laurens, 4

Excavating Ohio’s only Revolutionary War fort

Lawrence Martin: The Pickwickian Syndrome, 12

A deadly combination of obesity and too shallow breathing

Donald Dewey: Let’s Reorganize Major League Sports!, 25

Shouldn’t major league membership be based on performance?

Barbra Cunliffe Singleton: Walking the Wrong Way Around the Monastery, 31

Tibet’s cultural heritage is being erased under Chinese rule

John A.C. Greppin: The Language of the Babylonians and Assyrians, 37

Deciphering …

Selection Of Genetic Variants Of Simian Immunodeficiency Virus In Persistently Infected Rhesus Monkeys, Dawn P. Wooley, Ronald C. Desrosiers

Neuroscience, Cell Biology & Physiology Faculty Publications

Genetic and antigenic variation may be one means by which lentiviruses that cause AIDS avoid elimination by host immune responses. Genetic variation in the envelope gene (env) was studied by comparing the nucleotide sequences of 27 clones obtained from two rhesus monkeys infected with molecularly cloned simian immunodeficiency virus. All 27 clones differed from each other and differed from the input clone in the gp120 (SU) portion of the envelope gene. Nucleotide substitutions were shown to accumulate with time at an average rate of 8.5 per 1,000 per year in SU. Surprisingly, the majority of nucleotide substitutions (81%) resulted in …

The Chironian Vol. 108 Spring 1991, New York Medical College

The Chironian

No abstract provided.

Development And Characterization Of Monoclonal Antisperm Antibodies: Potential For Contraception, Dilrowshan H. Haque

Theses and Dissertations in Biomedical Sciences

There is an expressed need to develop a greater variety of safe contraceptive methods which would find acceptance worldwide, particularly in developing countries. Immunization against spermatozoa might be such a method as judged by the accumulated evidence from studies on human females and in a number of female animal species.

Two extraction techniques were used for sperm membrane antigen isolation. The first technique involved NP-40 detergent for antigen extraction from human motile sperm and the second technique employed homogenized human testis for antigen extraction. Using these immunogens, sperm membrane-specific monoclonal antibodies (MAbs) were developed. When these antisperm MAbs were subjected …

Mis-Taken On Lacan: The Manqué Business Of Psychoanalysis, Bennet Schaber

Syracuse Scholar (1979-1991)

No abstract provided.

What's Happening: March 13, 1991, Maine Medical Center

What's Happening

No abstract provided.

Amalgam Fillings: Do Dental Patients Have A Right To Informed Consent, Michael A. Royal

RISK: Health, Safety & Environment (1990-2002)

Recent animal studies have shown significant mercury absorption from dental fillings and resulted in unfavorable media attention. Yet, an FDA advisory committee has found no evidence of Risk to dental patients, and many dentists believe that patients are being unnecessarily alarmed. The paper reviews the history of amalgam fillings through the recent animal studies and concludes that the Risk, whatever it may prove to be, is sufficiently high to warrant permitting patients to choose between amalgam and alternative dental filling materials.

Nutrition Support Of Hiv+ Patients, Johanna T. Dwyer

Henry Ford Hospital Medical Journal

Case management strategies for the nutritional support of patients infected with the human immunodeficiency virus (HIV) are evolving as the disease becomes less rapidly fatal and more chronic. Nutritional status changes in advanced HIV infection are similar in many respects to protein-calorie malnutrition. Current clinical effort and research focuses on the beneficial effects of preserving lean body mass and keeping asymptomatic patients in good nutritional status by preventing micronutrient deficiencies and by treating preexisting nutritional problems rather than attempting to intervene late in the disease's course, after secondary malnutrition has already developed. Nutrition support and intervention trials only late in …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Disturbances In Lipid Metabolism Associated With Chylothorax And Its Management, Malachi J. Mckenna, Jau-Wen Chu, Dorothy M. Kahkonen

Henry Ford Hospital Medical Journal

Changes in circulating lipid status were studied in a 70-year-old woman during management of chylothorax that included chest drainage, pleuroperitoneal shunting, and a successful thoracic duct ligation. Hypolipidemia with a relative decline in high-density lipoprotein (HDL) cholesterol was apparent at presentation. Following recovery, serum HDL cholesterol rose to the upper limit of normal. Apolipoprotein A-l (Apo A-l) was discordantly raised during the period of pleuroperitoneal shunting. We speculate that diversion of chylomicrons to the liver with subsequent hydrolysis accounted for a release of Apo A-l particles into the circulation at a time when the formation of HDL was compromised by …

Molecular Mechanism Of The Stimulation Of Alkaline Phosphatase Activity In Human Bone Cells By 1,25(Oh)2 D3, Eru Kyeyune-Nyombi

Loma Linda University Electronic Theses, Dissertations & Projects

To facilitate this study an in vitro human model system was established that exhibited many aspects of normal osteoblasts. The human osteosarcoma cell line (TE85 cells) expressed a skeletal alkaline phosphatase activity (an accepted bone cell differentiation marker) which was stimulated by 1,25(OH)₂D₃ (a potent differentiating agent), under serum-free conditions in a dose-dependent, time-dependent, and cell density-dependent manner. Cytochemical analysis of the stimulation of ALP activity by 1,25(OH)₂D₃ showed that 1,25(OH)₂D₃ increased the number of TE85 cells that expressed detectable ALP activity, suggesting that 1,25(OH)₂D₃ promoted the process …

Catecholamines And The Regulation Of Uterine Contractions In The Pregnant Rhesus Macaque, Cahleen Mae Mcnutt

Loma Linda University Electronic Theses, Dissertations & Projects

This study was designed to test the hypothesis that: 1) maternal and/or amniotic fluid catecholamines or prostaglandins display nocturnal activity rhythms similar to those of the myometrial contractility in the pregnant rhesus macaque and, 2) catecholamines stimulate prostaglandin production by fetal membranes. Paired maternal arterial blood and amniotic fluid samples were collected at 0900 h (AM) and 2100 h (PM) from chronically catheterized rhesus macaques until delivery and analyzed for prostaglandin metabolites (PGFM and PGEM-II) and catecholamines (norepinephrine, epinephrine, and dopamine). Uterine activity data was continuously recorded. A rhythm in uterine contractility was observed, with peak activity between 1900 and …

Topographic Development Of The Corticocollicular Projection In The Neonatal Rat, F. Allen Richburg Ii

Loma Linda University Electronic Theses, Dissertations & Projects

The density and distribution of labeled cortical cells was examined following discrete deposits of retrograde tracers into the superior colliculus (SC) of neonatal and adult rats to study the topographic order of SC afferents from the cortex during the initial phase of axon ingrowth. Small deposits of red and green latex microspheres (0.02-0.05ul) were placed into the SC of rats ranging in age from birth to adulthood using glass micropipettes (tip diameter 25-35um). The animals, following a 48hr survival period, were deeply anesthetized and perfused with normal saline followed by a 10% formal-saline solution. The brains were sectioned coronally at …

Caduceus 1991, Stritch School Of Medicine

Stritch School of Medicine Yearbooks

No abstract provided.

The Gamut: A Journal Of Ideas And Information, No. 34, Winter 1991, Cleveland State University

The Gamut Archives

CONTENTS OF ISSUE NO. 34, WINTER, 1992

Editorial

Louis T. Milic: Not Taking It Lying Down, 3

Medicine

Lawrence Martin: Too Much Sugar, Too Little History, 5

The discovery of insulin

Books

Jack Matthews: Colloquies in a Pagan Land, 14

Opinions of an Ohio frontier preacher

Cleveland

Dan Grayson: Noshing Down East 105^th Street, 27

The sights, sounds, smells, and tastes of a Jewish neighborhood in the 1920’s

Fiction

Patrick Murphy: Tiger, 42

Collecting

An interview with Jack Saul: Over 100,000 Records, 55

Writing

Stuart Kollar: Too Many Writers, 67

Are numbers …

Evaluation Of Particulate Air Filters For Indoor Air Cleaning, Murray R. Clark, Kevin Tennal, Thomas Rimmer, Malay K. Mazumder

Journal of the Arkansas Academy of Science

No abstract provided.

Patterns Of Appraisal And Coping Across Different Stressor Conditions Among Former Prisoners Of War With And Without Posttraumatic Stress Disorder, John A. Fairbank, David J. Hansen, James M. Fitterling

Department of Psychology: Faculty Publications

Little is known about how survivors of extreme events cope with traumatic memories and subsequent negative life experiences. The present study compared (a) repatriated prisoners of war (RPWs) from World War II (WWII) with chronic posttraumatic stress disorder (PTSD), (b) RPWs without PTSD, and (c) noncombat veterans on measures of general psychological functioning, appraisal, and coping. Appraisal and coping were assessed under 2 stressor conditions: memories of war/captivity and recent negative life events. RPWs with PTSD reported poorer general psychological functioning; significantly less control over memories of WW II; and more frequent use of self-isolation, wishful thinking, self-blame, and social …

Development Of An Instrument To Identify Newborns At Risk Of Child Abuse Or Neglect, Denise Huan-Hsuan Kung Ihnat

Yale Medicine Thesis Digital Library

No abstract provided.

Virginia Dental Journal (Vol. 68, No. 2, 1991)

Virginia Dental Journal

No abstract provided.

Animals In Biomedical Research: The Undermining Effect Of The Rhetoric Of The Besieged, John P. Gluck, Steven R. Kubacki

Experimentation Collection

It is correctly asserted that the intensity of the current debate over the use of animals in biomedical research is unprecedented. The extent of expressed animosity and distrust has stunned many researchers. In response, researchers have tended to take a strategic defensive posture, which involves the assertation of several abstract positions that serve to obstruct resolution of the debate. Those abstractions include the notions that the animal protection movement is trivial and purely anti-intellectual in scope, that all science is good (and some especially so), and the belief that an ethical consensus can never really be reached between the parties.

Reflective Ethology, Applied Philosophy, And The Moral Status Of Animals, Marc Bekoff, Dale Jamieson

Experimental Research and Animal Welfare Collection

Currently there is an unprecedented interest in ethological studies of nonhuman animals. Much of this interest is motivated by a desire to learn more about animals themselves. For scientists assuming this stance, a secondary goal is to use this knowledge to assess the place of humans in the natural order of things, stressing continuity or discontinuity depending on one's views. Others, however, study animals primarily to apply this knowledge to human behavior. We argue that behavioral research demands the rigorous application of methods that are minimally harmful to the animals being studied. We argue for a moderate, but rigorous and …

GabaA And Excitatory Amino Acid Receptors In Dorsomedial Hypothalamus And Heart Rate In Rats, Robert P. Soltis, Joseph A. Dimicco

Scholarship and Professional Work – COPHS

We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in emotional stress. The purpose of this study was to determine whether excitatory amino acids (EAAs) can produce a cardiovascular response similar to that caused by the GABAA receptor antagonist bicuculline methiodide (BMI) when microinjected at the same hypothalamic site in urethan-anesthetized rats and to clarify the precise locus of action of these agents. N-methyl-D-aspartic acid (NMDA, 0.68-6.8 pmol/50 nl) and kainic acid (KA, 0.47-4.7 pmol/50 nl) produced dose-related …

Bacteremia Associated With Mortality In An Arkansas Alligator, James J. Daly, Sam W. Barkley, Peggy Benton

Journal of the Arkansas Academy of Science

No abstract provided.

Habitat Associations And Relative Densities Of Rodent Populations In Cultivated Areas Of Central Argentina, James N. Mills, Barbara A. Ellis, Kelly T. Mckee, Julio I. Maiztegui, James E. Childs

Zoonotics and Wildlife Disease: Publications

Small mammals were livetrapped during 12 months in crop fields and weedy borders at 18 sites in central Argentina. A total of 1,652 mammals of 14 species was captured during3 3,060 trap-nights. Six species of rodents comprised > 95% of captures. Periodically disturbed fields of crops were dominated by Calomys musculinus and C. laucha, and to a lesser extent Mus musculus. A second group composed of Akodon azarae, Bolomys obscures, and Oligoryzomys flavescens primarily inhabited the more stable, weedy borders of cultivated fields. Peaks in relative densities of C. musculinus, C. laucha, and M . musculus …