Digital Commons Network^™

Distribution Of Tamoxifen In Rat Tissues Duringsteady-State Treatment, Ayşe Kafkasli, Erkan Ünlenen, Beyhan Demi̇rhan, Saim Yoloğlu

Turkish Journal of Medical Sciences

Tamoxifen citrate (TAM), a nonsteroidal antiestrogen, is a drug of choice in the endocrine treatment for all stages of breast cancer in both pre and postmenopausal patients. The tissue distrubution of TAM alone and combined with medroxyprogesterone acetate (MPA) following long-term p.o. administration in immature rats is investigated in the present study. The highest consentrations of TAM has been found in the hypophysis in both groups. TAM consentrations were effected by MPA treatment in the liver and kidneys.

Superior Mesenteric Artery Flow Velocity Waveforms In Small For Gestational Age Fetuses, Eleanor Hoon Joo Rhee

Yale Medicine Thesis Digital Library

No abstract provided.

The Clinical-Chemical Parameters, Serum Lipoproteins And Fatty Infiltration Of The Liver In Ketotic Cows, Mutlu Sevi̇nç, Abdullah Başoğlu, İsmail Öztok, Mustafa Sandikçi, Fatih Bi̇rdane

Turkish Journal of Veterinary & Animal Sciences

The objective of this study was to provide a unique insight into the relationship between ketosis and fat cow syndrome using clinical-chemical parameters, serum lipoproteins and histopathological changes of the liver. The cholesterol and protein concentrations were significantly lower in the ketotic cows (p

Discovering The Recreational Interests Of South Florida's Youth For Use In The Expansion Of 4-H Programs In Broward County, Florida, Thomas W. Kehlhofer

Graduate Student Dissertations, Theses, Capstones, and Portfolios

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Autism : A Look Into Cause And Treatment, Sarah Chase Ferguson

Graduate Research Papers

This paper reviews the literature on the etiology and treatment of autism in an attempt to answer three questions. First, what are the main theories on the cause of autism? To answer this the theories of the psychoanalytic, behavioral, and biological perspectives are examined. Second, what treatment methods are available for children with autism? Ideas on treatment are discussed from each of. the three perspectives. In addition, UCLA's Young Autism Project and Project TEACCH are covered. Third, what is the nature of treatment? The importance of specific treatment in the areas of language, social skills and daily living skills is …

Youth Talk About Sexuality: A Participatory Assessment Of Adolescent Sexual And Reproductive Health In Lusaka, Zambia, Tamara Fetters, Evans Mupela, Naomi Rutenberg

Reproductive Health

Thirty-six percent of Zambia’s 9 million inhabitants are between 10 and 19 years of age, and most adolescents are sexually active by their mid-teens. Pregnant teenagers have an elevated risk of maternal mortality and complications related to birth. In 1990, at Lusaka’s University Teaching Hospital, self-induced abortion accounted for up to 30 percent of maternal mortality, and one-quarter of these deaths occurred in women under 18 years. Sexually transmitted infections (STIs) are a major health problem for adolescents, yet only a small proportion protect themselves from pregnancy and STIs. There are many barriers to improving the situation, including opposition by …

Etude Participative Pour L’Identification Des Stratégies Communautaires De Lutte Contre La Pratique De L’Excision Dans Le Bazéga, Direction De La Santé Et De La Famille (Dsf), University Of Ouagadougou Demographic Research Unit (Uerd), Mwangaza, Population Council

Reproductive Health

No abstract provided.

Evaluation De La Stratégie De Reconversion Des Exciseuses Pour L'Eradication Des Mutilations Génitales Féminines Au Mali, Population Council

Reproductive Health

No abstract provided.

Rapport Du Seminaire National [Au Mali] Pour La Definition D'Une Strategie D'Eradication De L'Excision, Population Council

Reproductive Health

This is a report on a workshop for the eradication of female genital mutilation (FGM) held in Bamako, Mali. The workshop presented the results of a literature review on FGM and the actions taken to counter the practice in Mali; provided updates on the activities of six national NGOs working on issues surrounding FGM; and developed a Plan of Action for activities aimed at reducing the practice. The workshop brought together 85 participants, including policy- and decisionmakers from the government, NGOs, and religious groups. The workshop led to the finalization of a national Plan of Action to the Year 2000 …

Country Profile Of Women's Health And Development In Indonesia, Population Council

Reproductive Health

The “Country Profile of Women’s Health and Development in Indonesia” contains a thorough review of the following: Geographical, Political, Socio-Demographic, and Economic Profile of Indonesia; Status of Women; and Women’s Health Status. In view of the complexity of the problems facing women, the document concludes that Indonesia needs a plan for the future with a gender perspective that prioritizes increased life expectancy, legal protection, and empowerment for women. To reach this goal, Indonesia started by ratifying the Convention on the Elimination of All forms of Discrimination Against Women (CEDAW) and set it into law in 1984. This convention, together with …

The Roles Of Transferrin Receptor In T Cell Activation, Allison Lorayne Bayer

MUSC Theses and Dissertations

Transferrin receptor (TfR) appears on activated T cells following interaction of the antigen-major histocompatibility complex (MHC) with the T cell receptor (TCR) and the resulting expression of IL-2 receptor (IL-2R). Previous work in the laboratory has demonstrated allograft prolongation following administration of anti-TfR monoclonal antibody (mAb). Studies in the area of cancer immunotherapy have shown that TfR blockade and modulation deprives the tumor of iron, which is essential for continued growth and proliferation, while TfR modulation results in poor T cell proliferation, respectively. This dissertation focuses on the hypothesis that modulation of T cell TfR expression is associated with altered …

Conditions Optimales D'Utilisation Des Nettoyants À Plancher : Gras Animaux Et Végétaux Sur Vinyle Et Grès, Philippe L'Homme, Sylvain Lamoureux, François Quirion

Rapports de recherche scientifique

Ce rapport présente et discute les résultats obtenus par QI Recherche et Développement Technologique dans le cadre de l'activité de recherche "Conditions optimales d'utilisation des nettoyants à plancher : Gras animaux et végétaux sur vinyle et grès". Le projet de recherche a débuté le 4 juillet 1997 pour se terminer avec le dépôt de ce rapport final, le 10 juin 1998. Cette activité s'inscrit dans l'effort de recherche de l'IRSST pour réduire l'incidence des chutes et glissades qui, entre 1993 et 1995, ont été à l'origine de plus de 12,800 cas de lésions chez les travailleurs du Québec.

Cette …

Hamstring Tendons As Autograft Replacements In Acl Reconstructions: A Review Of The Literature, Jason Anderson

Physical Therapy Scholarly Projects

Hamstring tendons have gained a great deal of acceptance in anterior cruciate ligament (ACL) reconstruction procedures in the 1990's, but some misconceptions concerning the ability of hamstring grafts to successfully replace ruptured ACLs still exist. More surgeons are using hamstring tendons to reconstruct ACL-deficient knees because their harvest does not disrupt the extensor mechanism of the knee. Enthusiasts of the hamstring graft believe that it promotes quicker return of quadriceps strength and knee range of motion without a prevalence of postoperative pateIIofemoral symptoms.

The purpose of this review is to dispute the concerns that exist concerning the initial tensile strength, …

A Review Of Periodization Of Strength And Its Clinical Implications To Physical Therapy, John Andrew

Physical Therapy Scholarly Projects

Currently no literature or studies in the physical therapy profession explore the use of periodization of strength principles. Therefore, the purpose of this independent study will be to perform a literature review of periodization of strength and how these training concepts are applicable to physical therapy.

Periodization is a strengthening technique which varies the training stimulus so that continuous gains in strength are accrued. The general progression of training is from low intensity and high volume to high intensity and low volume. To achieve these changes in intensity and volume the number of sets, repetitions, and load is periodically changed. …

The Effects Of Exercise On The Elderly Population: A Literature Review, Angela M. Thoreson

Physical Therapy Scholarly Projects

The population of those 65 years old or older has increased dramatically over the past several decades and will continue to grow well into the 21 st Century. This change in U.S. demography has also led to an increased interest in geriatric medicine and the implications physical activity has on the social, medical, and economical aspects of treating this patient population.

Research has shown that people who participate regularly in aerobic activity have lower mortality and morbidity rates, even if an exercise program is started later in life. Moderate exercise has been proven to be an important part of treatment …

The Effect Of Hippotherapy On Sitting Balance In Children With Cerebral Palsy, Theresa A. Jurgens

Physical Therapy Scholarly Projects

Hippotherapy programs have grown rapidly since 1969, when the first center opened in the United States. Despite the growing enthusiasm for hippotherapy in North America, research regarding the efficacy of hippotherapy is not well documented. Literature that pertains to the therapeutic benefits of hippotherapy consists primarily of descriptive articles containing subjective reports of riding instructors, riders, parents, and therapists. Hippotherapy is proposed to develop neuromuscular control, facilitate posture, elicit righting and equilibrium reactions, provide vestibular input, and improve psychological wellbeing. While these descriptive articles have identified variables to be empirically studied, few investigators have documented the therapeutic effects of hippotherapy. …

Exercise And Pregnancy: A Guide For Health Care Professionals, Stacy L. Ripplinger

Physical Therapy Scholarly Projects

Health and fitness has become nationwide trends resulting in people of all ages making wiser choices regarding nutrition and exercise. Pregnant women are also participating in this fitness revolution to help ease the discomforts of pregnancy, maintain fitness levels, and regain their shape after delivery. These women often turn to health care providers, including physical therapists, for guidance. The purpose of this independent study, accomplished by a review of the literature, is to provide physical therapists and general health care practitioners an overview of maternal body changes, nutritional requirements, and emotional changes that occur during pregnancy, and how these factors …

The Effect Of Pre-And Postnatal Cd Exposure Onconduction Velocity In Sciatic Nerve, Piraye Yargiçoğlu, Aysel Ağar, Ümit Kemal Şentürk, Nimet İzgüt Uysal, Derya Kiliç

Turkish Journal of Medical Sciences

The purpose of the study has been to investigate the effect of preand postnatal Cd exposure on conduction velocity of sciatic nerve. Pregnant Swiss albino rats were divided into three groups as control (C), cadmium (Cd) and non-cadmium (NCd) groups. Control animals received tap water while rats in Cd group received Cd as CdCl 2 in their drinking water during the experimental period. The mothers of the NCd group were given Cd during their pregnancy but given tap water after birth. Twenty-two days after birth (postnatal day 22) the rats were separated from the mothers. The present study was performed …

Amino Acid Neurotransmitter Levels In Thecerebral Cortex Of Mice Receivingimipenem/Cilastatin -Lack Of Excitotoxicity In Thecentral Nervous System, Mete Akisü, Nilgün Kültürsay, Canan Çoker, Çiler Akisü, Meral Baka

Turkish Journal of Medical Sciences

Imipenem, a very potent carbapenem derivative beta-lactam antibiotic, has recently found a major place in the treatment of antibiotic-resistant nosocomial infections. However, a convulsive side effect is seen in 0.2-3 percent of patients. Although it is suggested that this effect is due to the inhibition of gamma-aminobutyric acid (GABA) mediated inhibitory transmission, no study has been reported so far showing its effect on the cerebral cortex free inhibitory and excitatory amino acid levels. Twenty-one male TO albino mice were divided into three equal groups and given therapeutic (40 mg/kg/day) or excessive (500 mg/kg/day) doses of Imipenem/cilastatine (I/C) or saline solution …

A Method Of Identifying Hazardous Highway Locations Using The Principle Of Individual Lifetime Risk, Paul J. Ossenbruggen

RISK: Health, Safety & Environment (1990-2002)

Dr. Ossenbruggen presents a scientific framework for identifying hazardous highway locations that may be more easily understood by non-scientists and has potential for comparing highway with other risks to health.

Outlook Magazine, Winter 1998

Outlook Magazine

No abstract provided.

Outlook Magazine, Spring 1998

Outlook Magazine

No abstract provided.

Development Of An Elisa Method For The Measurement Of Cd44 Expression In Human Serum, Ciara Hurley

Theses

CD44 is a cell surface glycoprotein (mol. wt. =85-95 kDa) which has been implicated in lymphocyte-HEV interactions and the process of lymphocyte homing. CD44 is a complex glycoprotein which undergoes extensive alternative splicing to generate various CD44 isoforms. CD44 functions include the delivery of an activation signal to T-cells, binding to hyaluronate, mediation of lymphocyte homing, and the spread of metastatic cells. CD44 has been particularly implicated in the dissemination of non- Hodgkin's lymphoma and as such may serve as a useful prognostic marker of disease progression. CD44 measurement in serum may provide a rapid, inexpensive and relatively non-invasive prognostic …

Methicillin Resistant Staphylococcus Aureus (Mrsa): Molecular Detection And Dna Fingerprinting, Leslie Cotter

Theses

Throughout the 1990s, the incidence of methicillin-resistant Staphylococcus aureus has increased in many health care areas including acute and chronic care facilities, outpatient clinics and in the community. Once introduced into a health care environment, this nosocomial pathogen can spread rapidly and as MRSA are resistant to multiple antibiotics, treatment is often difficult. Therefore effective infection control measures are required to prevent cross-infection and further spread of endemic strains.

In this study, a sensitive and specific triplex-PCR assay was designed for MRSA detection, wherein three genes, the methicillin resistance gene (mecA). femA and the extracellular thermonuclease gene (rmc) were simultaneously …

Effects Of Prenatal Drug Exposure On Neurobehavioral Functioning In Young Infants, Yvette Blanchard, Patricia E. Suess, Marjorie Beeghly

All PTHMS Faculty Publications

In the newborn period, infants prenatally exposed to cocaine and other drugs show low scores on the Neonatal Behavioral Assessment Scale. Beyond that period, research is limited on the effects of prenatal drug exposure on neurobehavioral functioning. In this study we compared infants exposed to cocaine and other drugs and control infants from low socioeconomic backgrounds on measures of neurobehavioral functioning during neuromotor assessment at 1, 4 and 7 months of life. None of the measures of neurobehavioral functioning showed any significant group differences. This study did not support the hypothesis of disrupted neurobehavioral functioning beyond the neonatal period in …

Selecting Linear-Score Distributions For Modeling Milk-Culture Results, H. G. Allore, David J. Wilson, H. N. Erb, P. A. Oltenacu

Animal, Dairy, and Veterinary Science Faculty Publications

The data for this cross-sectional retrospective study are from surveys of 65 dairy-cattle herds in central New York, USA sampled between February, 1993 and March, 1995. The objective was to identify probability distributions of logarithmically transformed somatic-cell counts (linear score) for use in a simulation model of mastitis and milk quality. Probability density functions were estimated using maximum-likelihood estimators for the linear score of individual-cow composite milk samples culture negative and culture positive for the pathogens Streptococcus agalactiae, Streptococcus non-agalactiae, Staphylococcus aureus, and coagulase-negative staphylococci for the complete dataset and by bulk-tank somatic-cell count group (< 500 000, ≥ 500 000 SCC/ml). Based on the rankings of three goodness-of-fit tests (Anderson-Darling, Kolmogorov-Smirnov and x^{2 …}

Virginia Dental Journal (Vol. 75, No. 3, 1998)

Virginia Dental Journal

No abstract provided.

Gene Delivery By Negatively Charged Ternary Complexes Of Dna, Cationic Liposomes And Transferrin Or Fusigenic Peptides, Sérgio Simões, Vladimir Slepushkin, R. Caspar, Maria C. Pedroso De Lima, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

Potential problems with the use of viral vectors for gene therapy necessitate the development of efficient nonviral vectors. The association of transferrin, or the pH-sensitive peptide GALA, with cationic liposomes composed of 1,2-dioleoyl-3-(trimethylammonium) propane and its equimolar mixture with dioleoylphosphatidylethanolamine, under conditions where the liposome/DNA complex is negatively charged, drastically increased luciferase expression from pCMVluc. The percentage of cells transfected, measured by β-galactosidase expression, was also increased by about 10-fold. The zeta potential of the ternary complexes was lower than that of the liposome/DNA complexes. Transfection activity of positively charged complexes was also enhanced by association with transferrin, GALA or …

Gene Expression Following Traumatic Brain Injury, Rajiv Malhotra

Theses and Dissertations

The pathology which results from traumatic brain injury (TBI) have long been believed to be immediate and irreversible. However, recently it has been shown that, although the primary effects are virtually unavoidable, the secondary effects manifest themselves through biochemical processes set in motion at the time of the injury. These events are frequently mediated through the process of excitotoxicity, which results from a widespread release of excitatory neurotransmitters. These neurotransmitters go on to activate both ionotropic and metabotropic receptors. The signal transduction initiated through these receptor populations gives rise to changes in gene expression.

One result of this release of …

Changes In Gabaa̳ Receptor Expression And Alterations In Ca⁺⁺/Calmodulin-Dependent Protein Kinase Ii Activity In A Hippocampal Neuronal Culture Model Of Epilepsy, Robert Eagan Blair

Theses and Dissertations

Expression levels of GABAA receptor subunits and activity of the Ca++ /calmodulin-dependent protein kinase II (CaM kinase II) enzyme system were evaluated in an in vitro hippocampal neuronal culture model of epilepsy. Treatment of hippocampal neuronal cultures with Mg++-free media for 3 hours results in the induction of an enduring "epileptic" state as evidenced by the expression of spontaneous recurrent seizure (SRS) discharge. The induction of the SRS activity was shown to be a N-methyl-D-aspartate (NMDA) receptor, Ca++-dependent mechanism (Sombati and DeLorenzo, J Neurophys., 73 (4), 1995). Significant and long-lasting decreases in mRNA expression for the GABAA α2 and α5 …